Glidiab - litaelo tsa mokhoa oa ho khutlisa le hore na li bitsa bokae

Letlapa le leng le na le

ntho e sebetsang - gliclazide ho latela 100% ntho 80 mg,

baamohelang: lactose monohydrate, cellulose ea microcrystalline, starch ea litapole, hypromellose, magnesium stearate, talc, sodium carboxymethyl starch.

Matlapa a na le 'mala o mosoeu kapa o mosoeu ka' mala o mosehla kapa oa tranelate, sebopeho se sephara sa cylindrical, se nang le bevel.

Melemo ea pharmacological

Mofumahali

Ho chona ho phahameng. Kamora ho tsamaisoa ha molomo ka 80 mg, nako e phahameng ea khatello ke lihora tse 4, 'me boholo ba mahloriso a plasma ke 2.2-8 μg / ml. Puisano le liprotheine tsa plasma - 85-97%, bophahamo ba pokello - 0,35 l / kg. Khokahano ea plasma ea equilibrium e fihlelloa kamora matsatsi a mabeli. Ho felisoa ha halofo ea bophelo ke lihora tse 8-20. E tšeloa ka har'a sebete, ka sebopeho sa li-metabolites tse 8. Palo ea metabolite ea mantlha e fumanoeng maling ke 2-3% ea kakaretso ea lithethefatsi tse nkiloeng, ha e na thepa ea hypoglycemic, empa e na le phello ho microcirculation. E epolloa ke liphio - 70% ka sebopeho sa metabolites, e ka tlase ho 1% e sa fetoheng, ke mala: 12% ka sebopeho sa metabolites.

Mofumahali

Moemeli oa hypoglycemic ea molomo, e fumanoang molokong oa bobeli. E tsosa secretion ea insulin ke manyeme, e eketsa phello ea sekhahla sa "insulin" le "sensitivity" ea li-tishu tsa pherekano ho insulin.

E susumetsa ts'ebetso ea li-enzymes tse kenang ka hare - mesifa ea glycogen synthetase. Fokotsa nako ea ho qalella ho tloha motsotso oa ho ja ho isa ho qala ho secretion. E khutlisetsa tlhoro ea pele ea insulin secretion (ho fapana le tse ling tse tsoang sulfonylurea, ka mohlala, glibenclamide, e amang haholo nakong ea karolo ea bobeli ea secretion). Ntle le ho ama metabolism ea carbohydrate, e ama le microcirculation. E fokotsa "hyppripial hyperglycemia", e fokotsa mokokotlo oa masapo le ho kopanya lintho, e liehisa nts'etsopele ea parietal thrombosis, e boetse e sebetsa ka potlako, 'me e thibela tsoelo-pele ea micothrombosis le atherossteosis,' me e tsose mohato o amanang le lefu la methapo ea methapo ea methapo. E fokotsa nts'etsopele ea lefu la tsoekere le lefu la tsoekere sethaleng se sa eketseheng, le lefu la tsoekere le nang le tšebeliso ea nako e telele, ho bonahala ho fokotseha ho hoholo ha proteinuria. Ha e lebise keketseho ea boima ba 'mele, kaha e na le tšusumetso e phahameng tlhōrōng ea insulin secretion mme ha e bake hyperinsulinemia, e thusa ho fokotsa boima ba' mele ho bakuli ba batenya, ka mor'a lijo tse nepahetseng. E na le thepa ea anti-atherogenic, e theola khatello ea cholesterol e felletseng maling.

Tekanyetso le tsamaiso

Kahare, nakong ea lijo, tekanyetso ea pele e khothalletsoang ke 40 mg (matlapa a ½), tekanyetso ea letsatsi le letsatsi ke 80 mg (1 pilisi), tekanyetso ea letsatsi le letsatsi ke 160 mg (matlapa a 2 ho litekanyetso tse 2, hoseng le mantsiboea), lethal dose le leholo la letsatsi ke 320 mg (matlapa a 4 ho litekanyetso tse peli tse arohaneng - hoseng le mantsiboea). Tekanyetso e itšetlehile ka lilemo, ho teba ha lefu la tsoekere, khatello ea tsoekere maling maling ka mpeng e se nang letho le lihora tse peli kamora ho ja.

Phetoho e 'ngoe le e' ngoe ea kokoana-hloko e latelang e ka etsoa kamora bonyane libeke tse peli. Haeba moriana o hlotsoe, ka letsatsi le hlahlamang lethalano ha lea lokela ho eketsoa.

Ho bakuli ba tsofetseng kapa ho sa sebetseng hantle hantle ha renal ho ba bonolo ho leka-lekana ho feta tekano (tumello ea creatinine - 15-80 di ml / min), moriana o beoa tekanyetso e tšoanang.

Contraindication

hypersensitivity ho li-gliclazide kapa likarolo tse thusang tsa lithethefatsi, hammoho le lintho tse ling tse tsoang ho sulfonylurea

mofuta oa 1 lefu la tsoekere

lefu la tsoekere le letala

ho hloleha ho matla ha hepatic le / kapa ho hlaba

Pheko e kopanetsoeng le miconazole

ho ima, ho nyeka

bana le bacha ba ka tlase ho lilemo tse 18

Ka tlhokomelo

Batho ba tsofetseng, ba sa tsubeng le / kapa ba sa fumaneng phepo e nepahetseng, mafu a matla a tsamaiso ea methapo ea pelo (ho kenyeletsa le lefu la pelo, atherosclerosis), hypothyroidism, ho hlaka kapa ho hloleha hoa setho, hypopituitarism, renal le / kapa ho hloleha ha sebete, kalafo ea glucocorticosteroid ea nako e telele. , khaello ea glucose-6-phosphate dehydrogenase, phekolo e kopaneng le phenylbutazone le danazole.

Litlamorao

- hypoglycemia (e khahlanong le regimen ea litekanyetso le lijo tse sa lekaneng)

- hlooho e opang, ho tsekela, ho tepella, tlala, ho fufuleloa, bofokoli bo matla

- palpitations, arrhythmia, khatello ea mali e eketsehileng

- ho otsela, ho hloka boroko, ho ruruha, ho ba mabifi, ho tšoenyeha, ho teneha, ho fokotseha ho tsepamisa mohopolo, ho sitoa ho tsepamisa mohopolo le ho etsa lintho butle, ho tepella maikutlo, pono e sa sebetseng

- aphasia, ho thothomela, paresis, ho ferekana ha maikutlo, ho ikutloa eka ha ho na thuso,

tahlehelo ea boitšoaro

- Ho phefumoloha ho sa tebang, bradycardia, ho fokotseha ha letsoalo, Komisi

- ho nyekeloa ke pelo, ho hlatsa, bohloko ba ka mpeng, ho qhekella, lets'ollo (ho omella hoa theoha ka lijo)

- ts'ebetso ea sebete e sa sebetseng (hepatitis, cholestatic jaundice - e hloka ho khaoloa hoa moriana, ts'ebetso e eketsehileng ea transaminase ea "sebete", alkaline phosphatase)

- Inhibition ea masapo a hematopoiesis (phokolo ea mali, thrombocytopenia, leukopenia, granulocytopenia)

- karabelo: - ho hlohlona ha letlalo, urticaria, lekhopho la letlalo (ho kenyelletsa maculopapular le bulous), erythema

- litla-morao tse tloaelehileng tsa derivatives ea sulfonylurea: erythropenia, agranulocytosis, hemolytic anemia, pancytopenia, allergic vasculitis, lefu le fokotsang sebete

Ho sebelisana le lithethefatsi

Ho ntlafatsa phello ea li-anticoagulants (warfarin); tokiso ea litekanyetso tsa anticoagulant e ka hlokahala.

Miconazole (e nang le tsamaiso ea methapo le ha o sebelisa li-gel ho mucosa ea molomo) e ntlafatsa phello ea hypoglycemic ea lithethefatsi (hypoglycemia e ka ba ho fihla ho komisi).

Phenylbutazone (tsamaiso ea methapo) e ntlafatsa phello ea hypoglycemic ea lithethefatsi (maqhubu ka lebaka la liprotheine tsa plasma le / kapa e liehisa ho tsoa 'meleng), taolo ea tsoekere ea mali le tokiso ea litekanyetso tsa glyclazide lia hlokahala, ka bobeli nakong ea tsamaiso ea phenylbutazone le ka mor'a ho tlohela.

Lithethefatsi tse nang le ethanol le ethanol li ntlafatsa hypoglycemia, tse thibelang karabelo e lumellanang, li ka kenya letsoho kholisong ea komello ea hypoglycemic.

Ka tsamaiso e ts'oanang le lithethefatsi tse ling tsa hypoglycemic (insulin, acarbose, biguanides), beta-blockers, fluconazole, angiotensin e fetolang enzyme inhibitors (ACE) (Captopril, enalapril), H2-histamine receptor blockers (cytoxidamides, cytaminidamines) le lithethefatsi tse seng khahlanong le ts'oaetso tsa kokoana-hloko - litekanyetso tsa hypoglycemic le kotsi ea hypoglycemia.

Danazole e baka lefu la tsoekere. Ha e kopantsoe le gliclazide, ho hlokahala ho laola tsoekere ea mali le ho ntlafatsa tekanyetso ea gliclazide, ka bobeli nakong ea tsamaiso ea danazol le ka mor'a ho tlohela.

Chlorpromazine ka tekanyetso e phahameng (ho feta 100 mg / ka letsatsi) e eketsa sethala sa glucose maling, e fokotsa sekhahla sa insulin. Hoa hlokahala ho laola tsoekere ea mali le ho ntlafatsa tekanyetso ea gliclazide, ka bobeli nakong ea tsamaiso ea chlorpromazine le ka mor'a ho tlohela.

Glucocorticosteroids (systemic, intraarticular ,angaphandle, rectal tsamaiso) e eketsa tsoekere ea mali ka nts'etsopele e ka bang teng ea ketoacidosis (ho fokotseha ha mamello ea carbohydrate). Hoa hlokahala ho laola tsoekere ea mali le ho ntlafatsa tekanyetso ea gliclazide, ka bobeli nakong ea tsamaiso ea li-glucocorticosteroids le ka mor'a ho tlohela.

Ritodrin, salbutamol, terbutaline (iv) - eketsa tsoekere ea mali. Ho khothalletsoa taolo ea tsoekere ea mali 'me, haeba ho hlokahala, phetisetso ea mokuli ho ea kalafo ea insulin.

Litaelo tse khethehileng

Ha u ntse u sebelisa moriana o joalo, ho hlokahala boikemisetso ba ho itšireletsa glucose ea mali le hemoglobin ea glycosylated.

Lits'oaetso tse kholo tsa ho buoa le ho lemala, ho chesa haholo, mafu a tšoaetsanoang a nang le febrile syndrome ho ka hloka hore a khaoloe lithethefatsi tsa molomo tsa hypoglycemic le tsamaiso ea insulin.

Bakuli ba lokela ho hlokomelisoa ka kotsi e eketsehang ea hypoglycemia maemong a ho nka lithethefatsi tse nang le ethanol le ethanol (ho kenyelletsa le ts'oaetso ea maikutlo a kang a disulfiram: bohloko ba ka mpeng, ho nyekeloa, ho hlatsa, hlooho), lithethefatsi tse seng tsa ts'oaetso tsa antiidal.

Phetoho ea tekanyetso ea hlokahala bakeng sa ho fetella hoa mmele le maikutlo, phetoho ea lijo.

Ha e le molao, matšoao a hypoglycemia a nyamela kamora ho ja lijo tse nang le lik'habohaedreite (mohlala, tsoekere), le ha tšebeliso ea li-sweeteners ha e thusa ho tlosa matšoao a hypoglycemic. Hypoglycemia e ka khutla le ha e ne e le pholiso e ntle ea pele. Haeba matšoao a hypoglycemic a le matla kapa a le telele, le maemong a ntlafatso ea nakoana kamora ho ja lijo tse nang le lik'habohaedreite, ho hlokahala tlhokomelo ea tšohanyetso ea bongaka, ho fihlela sepetlele.

Haholo-holo a amehang ka ketso ea lithethefatsi tsa hypoglycemic ke batho ba tsofetseng, bakuli ba sa fumaneng lijo tse nang le phepo e nepahetseng, ba nang le boemo bo fokolang ba kakaretso, bakuli ba nang le bothata ba ho hloka pituitary-adrenal. Lipontšo tsa kliniki tsa hypoglycemia li ka koaloa ha ho nkuoa li-beta-blockers, clonidine, reserpine, guanethidine. Nts'etsopele ea khatello ea bobeli ea lithethefatsi e ka etsahala (e tlameha ho khetholloa ho ea mantlha, moo moriana o sa feng phello e lebelletsoeng ea kliniki nakong ea kopano ea pele).

Ho fana ka litlhare tsa sulfonylurea ho bakuli ba nang le khaello ea glucose-6-phosphate dehydrogenase (G6PD) ho ka lebisa ho hemolytic anemia. Ho lokela hore ho sebelisoe tlhokomeliso ha ho laeloa Glidiab ho bakuli ba nang le khaello ea G6PD mme u nahane ka monyetla oa kalafo e fapaneng le sehlopha se seng sa lithethefatsi.

Karolo ea lithethefatsi e kenyelletsa lactose monohydrate, mabapi le sena, Glidiab ha ea lokela ho sebelisoa ho bakuli ba nang le lefutso la tsoalo, glucose-galactose malabsorption le khaello ea lactase.

Lintlha tsa phello ea lithethefatsi ho bokhoni ba ho khanna koloi kapa mekhoa e ka bang kotsi

Nakong ea kalafo, tlhokomelo e lokela ho nkuoa ha ho khannoa likoloi le ho etsa lintho tse ling tse ka bang kotsi tse hlokang ho tsepamisa mohopolo le ho potlakisa karabelo ea maikutlo haholo.

Bongata

Matšoao: hypoglycemia, ho hloka kelello ho tseba hantle, hypoglycemic coma.

Phekolo: haeba mokuli a hlokahalletse, a inke tsoekere, haeba a sa tsebe letho, a tsamaise tharollo ea 40% dextrose, joale iv 5% dextrose solution e fihlelle ho fihlela ts'oarello ea glucose ea mali e fihla ho 5.55 mol / l, 1-2 mg glucagon v / m, ho shebella ho kenella ha tsoekere maling maling a mang le a mang a 15, hammoho le ho khetholla pH, urea, creatinine le li-elektrone maling. Kamora ho hlaphoheloa kelellong, ho bohlokoa ho fa mokuli lijo tse nang le lik'habohaedreite tse bonolo tse tsoang habonolo (molemong oa ho qoba tsoelopele ea hypoglycemia). Ka lefu la mokokotlo la mokokotlo, mannitol le dexamethasone. Ho buoa ka meno ha ho na thuso.

Moetsi

AKRIKHIN OJSC, Russia

142450, sebaka sa Moscow, setereke sa Noginsky, toropo ea Staraya Kupavna,

Fono / Fekse: (495) 702-95-03.

Lebitso le naha ea setifikeiti sa ngoliso

AKRIKHIN OJSC, Russia

Aterese ea mokhatlo e amohelang litletlebo tse tsoang ho bareki ka boleng ba lihlahisoa (thepa) sebakeng sa Rephabliki ea Kazakhstan:

AKRIKHIN OJSC, Russia

142450, sebaka sa Moscow, setereke sa Noginsky, toropo ea Staraya Kupavna,

Glidiab MV e etsa joang

Matla a laolang glycemic a hlokahala ho thibela mathata a morao a lefu la tsoekere. Joaloka molao, mofuta oa kalafo o kenyelletsa khalemelo ea phepo e nepahetseng le tšebetso. Ka lefu la mofuta oa 2, mehato ena hangata ha e lekane, ka hona potso e hlaha ea ho beoa ha litlhare tse fokotsang tsoekere. Karolo ea pele ea lefu lena e tšoauoa ka ho hanyetsa insulin le tlhahiso e eketsehang ea tsoekere maling, ka hona ka nako ena lithethefatsi tse sebetsang haholo ke metformin (mohlala, Glucofage).

Hyperglycemia e sa foleng ka nako e khuts'oane e lebisa ho ho senyeha ha lisele tsa pancreatic le ho senyeha ha insulin. Ha liphetoho tse joalo li qala, ho bohlokoa ho eketsa matlapa kalafong e boletsoeng esale pele e ka susumetsang tlhahiso ea insulin. Bakeng sa litlhare tse fumanehang hona joale, DPP4 inhibitors, incretin mimetics, le sulfonylureas li khona ho etsa sena.

Lihlopha tsa pele tse peli li sebelisoa haufinyane, leha lithethefatsi li sebetsa, empa li theko e boima. Libakeng tse ngata tsa Russia, ho li fumana mahala ke bothata. Empa melemo e sa bitseng chelete e ngata ea sulfonylureas e netefalitsoe hore e tla fanoa tliliniking e 'ngoe le e' ngoe. Lithethefatsi tse sireletsehileng ka ho fetisisa le tsa sejoale-joale ke glimepiride (Amaryl) le mofuta o fetotsoeng oa glyclazide (Diabeton MV le analogue, ho kenyeletsa Glidiab MV)

Diabetes ke setlhare sa mantlha, Glidiab ke generic ea lapeng e boleng bo botle. Boithuto bo netefalitse litlamorao tse tšoanang tsa lithethefatsi tsena ho glycemia.

Litaelo tsa ts'ebeliso li hlalosa liketso tse 'maloa tsa bohlokoa tsa Glidiab:

1. Pholoso ea karolo ea 1 ea tlhahiso ea insulin, ka lebaka leo tsoekere e qalang ho tlohela likepe hang hoba e fihle.
2. Amplization 2 mekhahlelo.
3. Ho fokotsa ho khokhotheha ha liplatelete, ho ntlafatsa bokhoni ba vasiti ea epithelium ea ho qhibilihisa thrombi. Phello ena e fokotsa menyetla ea mathata a mokelikeli.
4. Nutralization ea li-radicals tsa mahala, palo ea tsona e eketseha le lefu la tsoekere.

Ho na le lithuto tse bontšang hore litokisetso tsa sulfonylurea li tlisa tšenyo ea lisele tsa beta, li lebisa ho haelloang ke insulin le ho qobella ba lefu la tsoekere ho fetohela kalafo ea insulin. Glidiab sehlopheng sa eona ke e 'ngoe ea lithethefatsi tse sireletsehileng ntlheng ena. Tekanyo e tloaelehileng ea lithethefatsi e eketsa tlhahiso ea lihormone ka 30%, kamora moo tlhahiso ea eona e theohelang ka 5% selemo se seng le se seng. Boemong ba tlhaho ba lefu lena, khaello ea insulin e eketseha selemo le selemo ka 4%. Ka mantsoe a mang, ho ke ke ha khoneha ho bitsa Glidiab e sireletsehile ka botlalo bakeng sa manyeme, empa hape ho ka se khonehe ho e lekanya le lithethefatsi tse matla tse tsoang sehlopheng se le seng, ka mohlala, Maninil.

Matšoao a ho khethoa ha moriana

Ho ea ka litaelo, Glidiab e laeloa feela ho batho ba lefu la tsoekere ba nang le mefuta e 'meli ea mafu a amanang le carbohydrate. Litlamorao tsa lithethefatsi li lebisoa ka kotloloho ho lisele tsa beta, tse sieo mofuteng oa 1 oa lefu la tsoekere. Phekolo e tlameha ho kopantsoe le lijo le boikoetliso, le botenya le / kapa ho hanyetsa insulin, metformin e eketsoa.

Glidiab e khethoa feela joalo ka moemeli oa metformin, mme feela ha mokuli a phetha litaelo tsohle, empa a sa khone ho fihlella glycemia e lebisitsoeng. E le molao, sena se bontša tahlehelo e itseng ea mosebetsi oa pancreatic. Ho netefatsa khaello ea insulin le tlhoko ea Glidiab, ho bohlokoa hore u nke tlhahlobo ea C-peptide.

Qalong ea lefu lena, moriana o khethoa feela ha tsoekere e maling e phahame haholo, mme ho na le lipelaelo tsa hore lefu la tsoekere le fumanoe lilemo tse 'maloa hamorao ho feta kamoo le qalileng.

Mofuta oa litekanyetso le litekanyetso

Moetsi o hlahisa Glidiab ka mefuta e 'meli:

1. Tekanyo ea Glidiab ea 80 mg. Tsena ke matlapa a setso a nang le gliclazide, ntho e sebetsang e tsoang ho tsona e kenella ka potlako maling ebe e fihla sehlohlolong sa tlhoro kamora lihora tse 4. E ne e le ka nako ena moo kotsi e phahameng ka ho fetisisa ea hypoglycemia. Tekanyetso e kaholimo ho 160 mg e arotsoe ka litekanyetso tse peli, kahoo tsoekere e ka theoha khafetsa motšehare.
2. Glidiab MV ke ea sejoale-joale, matlapa a entsoe ka tsela eo gliclazide e tsoang ho bona e kenang maling butle butle hape. Sena ke seo ho thoeng se fetotsoe, kapa sa nako e telele. Ka lebaka la eona, phello ea Glidiab e eketseha hantle 'me ka nako e telele e bolokiloe ka tekanyo e ts'oanang, e eketsang katleho ea lithethefatsi, e fokotsa tekanyetso e hlokahalang, hape e qoba hypoglycemia.

Phapang ea theko lipakeng tsa lithethefatsi tsena e nyane - Glidiab MV e theko e boima haholo ke li-ruble tse ka bang 20, mme phapano ea polokeho e bohlokoa, ka lebaka leo, moetsi o khothaletsa hore lefu la tsoekere le fetohe moriana o mocha. Ho latela ts'ebetso ea eona, Letlapa le le leng la Glidiab 80 le lekana le Letlapa le le leng la Glidiab MV 30.

Tekanyetso e khothalletsoang:

Molao oa ho eketsa litekanyetso ho latela litaelo tsa ts'ebeliso: haeba lethalinyana le qalang le sa lekana, le ka eketsoa ka 30 mg (80 bakeng sa Glidiab e tloaelehileng) kamora khoeli ea tsamaiso. O ka eketsa lethalinyana pele ho ba lefu la tsoekere leo tsoekere ea mali le sa fetohang. Keketseho e potlakileng ea litekanyetso li kotsi ka coma ea hypoglycemic.

Mokhoa oa ho sebelisa Glidiab

Glidiab

Glidiab MV

Ho ea ka lingaka, bakuli ba nang le mafu a sa foleng ha ba noe meriana eohle e laetsoeng. Ka lefu la tsoekere la mofuta oa 2, ho hloka taolo ha ho felle feela ka tsoekere e phahameng ea mali, ka hona bakuli ba qobelloa ho nka meriana ea "statin" "aspirin" le meriana ea khatello ea mali ntle le lithethefatsi tse fokotsang tsoekere. Ho na le matlapa a mangata mme ho thata le mofuta oa moriana, ho fokotsa monyetla oa hore ba noe ka mokhoa o laoloang. Glidiab MV e nooa hanngoe ka letsatsi, ho sa tsotelehe tekanyetso e boletsoeng, ka hona, ho na le monyetla oa ho hloloheloa tekanyetso.

Ngaka ea Saense ea Bongaka, Hlooho ea Setsi sa Lefapha la Diabetes - Tatyana Yakovleva

Ke qetile lilemo tse ngata ke ithuta lefu la tsoekere. Hoa tšosa ha batho ba bangata ba shoa, mme le ho feta ba holofala ka lebaka la lefu la tsoekere.

Ke potlakela ho bolela litaba tse molemo - Setsi sa Patlisiso ea Endocrinological sa Russian Academy of Medical Science se atlehile ho hlahisa moriana o folisang lefu la tsoekere ka botlalo. Hona joale, katleho ea sethethefatsi sena e atametse 98%.

Litaba tse ling tse monate: Lekala la Bophelo le se le iphumanetse tšebetso ea lenaneo le ikhethileng bakeng sa litšenyehelo tse phahameng tsa lithethefatsi. Naheng ea Russia, ba lefu la tsoekere HO fihlela ka la 18 Motšeanong (ho kenyeletsoa) ka e fumana - Bakeng sa li-ruble tse 147 feela!

Litlamorao ke life?

Lethathamo la litlamorao tse sa rateheng tse ka bang teng ha o nka Glidiab MV 30 mg le li-analogues tsa eona:

1. Hypoglycemia e etsahala ka lithethefatsi tse ngata, ho tlola lijo kapa ho haelloa ke lik'habohaedreite ho eona. Ho theoha ha tsoekere hangata ho hloka khalemelo e matlafatsang le phokotso ea tekanyetso ea Glidiab.
2. Mathata a amanang le ho ja. Ho fokotsa kotsi ea litla-morao tsena, thupelo e khothaletsa ho nka Glidiab ka nako e tšoanang le lijo.
3. Mathata a letlalo. Ho latela maikutlo, litla-morao tse tebileng le ho feta ha li etsahale.
4. Fetoha ka har'a litaba tsa likarolo tse maling. Hangata e fetoha phetoho, ka mantsoe a mang, e itsoella kamora ho khaotsa ho amoheloa.

Kotsi ea hypoglycemia e hakanyetsoa ho 5%, e leng tlase haholo ho feta ka sulfonylureas ea khale. Batho ba nang le lefu la tsoekere ba kopana le mafu a matla a pelo le tsamaiso ea endocrine, hammoho le ho nka lihormone nako e telele, ba tloaetse ho theoha ha tsoekere. Bakeng sa bona, tekanyetso e phahameng e lumelletsoeng ea Glidiab e lekantsoe ho 30 mg. Litsebi tsa lefu la tsoekere le neuropathy, ba tsofetseng, bakuli ba nang le hypoglycemia ea khafetsa kapa ea nako e telele, ba khaotsa ho utloa matšoao a tsoekere e tlase, kahoo ho nka Glidiab ho ka ba kotsi ho bona. Tabeng ena, ho khothalletsoa litafole tsa tsoekere tse se nang litlamorao tse joalo.

Li-analogues tse tsebahalang

Har'a matlapa a antidiabetesic bakeng sa kalafo ea lefu la mofuta oa 2, litokisetso tsa glyclazide tse ajoang ka bongata. Ke Metformin feela e ka qothisanang lehlokoa le bona ka palo ea mabitso a ngolisitsoeng a khoebo. Boholo ba li-analogues tsa Glidiab li entsoe Russia, theko ea bona lithekeng e fapana pakeng tsa li-ruble tse 120-150, theko e phahameng ka ho fetisisa ea mantlha ea French Diabetes e batla li-ruble tse 350.

Lingoloa tsa Glidiab le tse nkang sebaka:

Glidiab kapa Gliclazide - e leng betere?

Boleng ba lithethefatsi bo khethoa ke tekanyo ea tlhoekiso le ho nepahala ha litekanyetso tsa ntho e sebetsang, polokeho ea likarolo tse thusang. Glidiab le Glyclazide (tlhahiso ea Ozone) li ts'oana hantle ho likarolo tsena. Akrikhin le Ozone ka bobeli ba na le lisebelisoa tsa sejoale-joale, lik'hamphani ka bobeli ha li hlahise thepa ea meriana, empa li e reka ho feta moo, ho tsoa ho baetsi ba China ba tšoanang. Le ha e le sebopeho sa ba tlatsitsoeng, Glidiab le Gliclazide ba batla ba pheta-pheta. Litlhahlobo tsa batho ba qetileng nako e fetang selemo le tsona li netefatsa katleho ea bona e tšoanang ho lefu la tsoekere.

Glyclazide e na le likhetho tsa 2 tsa litekanyetso - 30/60 mg, Glidiab - 30 mg feela, Glidiab e ka fetoloa mme ea lokolloa ka mokhoa o tloaelehileng, Gliclazide e hlahisoa e atolositsoe feela - ke liphapang tsohle pakeng tsa matlapa ana.

Mokhoa oa ts'ebetso le lipontšo tsa ts'ebeliso

Glidiab MV ke moemeli oa hypoglycemic oa sehlopha sa litlatsetso tsa sulfonylurea molokong oa bobeli. Moriana ona o na le gliclazide le bakuli. Glyclazide letlapeng le le leng e na le 80 mg kapa 30 mg.

Karolo e sebetsang ea sethethefatsi e sebetsa joang? Glyclazide holim 'a ho monya ho matlafatsa ts'ebetso ea mesifa ea glycogen synthetase le secretion ea insulin. Hape, ntho ena e hlahisa phello ea sephiri sa "insulin", mme e kenya letsoho ho eketsong hoa kutloisiso ea lisele tsa pherekano ho insulin.

Ho feta moo, gliclazide e thusa ho fokotsa lekhalo lipakeng tsa lijo le ho kenella ha "insulin" e sebetsang. Haeba u sheba litaelo tseo u ka li sebelisang ho Glidiab, u ka fumana hore ha u sebelisa matlapa, tlhoro ea "hyperglycemia" ea fokotseha, 'me tlhoro ea pele ea "insulin secretion" ea tsosolosoa.

Lintlha tsena kaofela li ama metabolism ea carbohydrate le microcirculation ka kotloloho. Haeba u lumela litaelo, Glidiab MV e thusa ho fokotsa ho khomarela le ho kopanngoa ha liplatelete, 'me ka nako e ts'oanang ho etsa hore ho be le bothata ba vascular. Ka mantsoe a mang, ka tšebeliso ea matlapa, menyetla ea tsoelo-pele ea microthrombosis le atherosclerosis e fokotsehile haholo.

Boithuto hape bo fumane hore moemeli oa hypoglycemic o thusa ho liehisa nts'etsopele ea mathata a kang lefu la tsoekere sethaleng se sa feteleng pele. Ho feta moo, ho sebelisa matlapa a Glidiab MV ho ka eketsa haholo katleho ea kalafo ea ho ja ho bakuli ba fetang boima.

Ke kopa ho tseba hore li-metabolites tsa moriana li qheleloa ka thipa hammoho le moroto ka sebopeho se sa fetoheng, 'me hammoho le lits'oants'o tsa mofuta oa metabolites.

Litaelo tsa tšebeliso ea lithethefatsi

Ke maemong afe moo ho khothalletsoang ho sebelisa matlapa a Glidiab 80? Litaelo li re ho bohlokoa ho sebelisa lithethefatsi kalafo ea lefu la tsoekere la mofuta oa 2, haeba kalafo ea lijo le ho ikoetlisa li sa thusa ho tsitsisa tsoekere ea glucose.

Ka kopanelo le meriana e meng, Glidiab MB ha e sebelisoe hangata. Empa ho lokela ho hopoloa hore phello ea hypoglycemic ea lithethefatsi e ka eketseha haeba, hammoho le kalafo ea lithethefatsi, ho ja le ho bapala lipapali ho lekane.

U ka sebelisa meriana joang? Motsoako oa pele ke 80 mg. Ho feta moo, khafetsa tšebeliso ke makhetlo a mabeli ka letsatsi - hoseng le ka shoalane. Ho khothalletsoa ho nka litafole metsotso e 30-60 pele u ja.

Haeba tekanyetso e nyane ea 80 mg ha e na phello ea hypoglycemic, joale litekanyetso li eketseha butle-butle. Ka tloaelo, lefu la tsoekere la mofuta oa 2, lethal dose ea 160 mg e nepahetse. Tekanyo e phahameng ea lithethefatsi ke 320 mg.

Empa re tlameha ho hopola hore ka tekanyetso e kholo, menyetla ea tsoelo-pele ea hypoglycemia le mathata a mang e eketseha haholo.

Ho sebelisana le lithethefatsi le likhohlano

Ho lokela ho hopoloa hore lithethefatsi tse ngata li khona ho eketsa phello ea hypoglycemic ea sehlahisoa sa Glidiab MB. Kahoo, litaelo li tiisa hore moriana o lokela ho kopanngoa ka hloko le li-blockamine H2-receptor blockers, lithethefatsi tse seng khahlanong le 'mele tsa ho nyehlisa, baemeli ba antifungal, li-inhibitors tsa ACE.

Lithethefatsi tse khahlanong le lefuba, li-beta-adrenoblockers, li-anticoagulants tse sa tobang, li-anabolic steroids, li-inhibitors tsa MAO, li-salicylates le tse ling li khona ho eketsa litlamorao tsa hypoglycemic.

Ke ka hona, pele u sebelisa matlapa a Glidiab, o lokela ho ithuta litaelo ka hloko le ho bona ngaka.

Har'a lintho tse hanyetsanang le tšebeliso ea matlapa,

1. Mofuta oa 1 oa lefu la tsoekere o itšetleha ka insulin.
2. Lefu la tsoekere la ketoacidosis.
3. E khahla kapa e boreleli. Ho feta moo, khokahano e tiileng ea molao ke hyperosmolar coma.
4. Leukopenia
5. Nako ea kemaro.
6. Nako ea lebone.
7. Ho hloleha ho matla ha hepatic le renal.
8. Maemo a tsamaeang le tlolo ea ts'ebetso ea ho monya lijo, le nts'etsopele ea hypoglycemia. Maemo a joalo a kenyelletsa ho kenella ka mpeng, mala a ka mpeng le mafu a tšoaetsanoang.
9. Allergy ho likarolo tsa matlapa.
10. Maemo ao ho ka 'nang ha hlokahala kalafo ea insulin. Maemo ana a kenyelletsa ho chesa, likotsi kapa ho buuoa.
11. Bokhoba ba tahi
12. Febrile syndrome.

Hape, lithethefatsi li lokela ho sebelisoa ka hloko ho batho ba nang le bothata ba ho hlobaela ha qoqotho.

Litlhahlobo le litlamorao tsa Glidiab

Maikutlo ke afe ka Glidiab? Litsebi tsa lefu la tsoekere li arabela hantle lithethefatsing. Batho ba bangata ba khahloa ke litheko tse tlase tsa lithethefatsi, le litheko tse phahameng tsa lona.

Ho feta moo, Gladiab, ho ea ka lefu la tsoekere, e ntle hobane ha e bake litla-morao ka litekanyetso tse tlase. Tšobotsi e 'ngoe ea moriana ho batho ke hore e eketsa katleho ea kalafo ea ho ja.

Litlamorao li ka baka litlamorao life? Ho latela litaelo, meriana e ka baka:

• Tlas'a tsamaiso ea endocrine. Li bonahala e le hypoglycemia. Empa ho lokela ho hlokomeloa hore motsoako ona o hlaha feela ka tekanyetso e sa khethiloeng ea moriana.
• Ho teneha, ho otsela, litlhaselo tsa mabifi, ho thothomela ha maoto le matsoho, hlooho ea hlooho, ho tsekela, ho tapa ho eketsehileng.
• Ho fokotseha hoa pono.
• Aphasia.
• Bradycardia
• Ho phefumoloha ho sa feleng.
• Delirium.
• Thrombocytopenia, anemia, leukopenia.
• Litla-morao.
• Ho se sebetse hantle tsamaisong ea lijo. Motho a ka ts'oaroa ke lets'ollo, ho ikutloa a le boima sebakeng sa epigastric, ho nyekeloa ke pelo, ho ipolaisa tlala, jaundice ea cholestatic, mosebetsi o eketsehileng oa lipilisi tsa hepatic transaminases.

Hangata, litla-morao li iphekola kamora ho tlohela moriana le ho fumana kalafo e loketseng ea matšoao.

Analogue e ntle ka ho fetisisa ea Glidiab

Litšoantšiso tsa Glidiab ke eng? Sebakeng seo, ho ka sebelisoa li-agents tse fapaneng tsa hypoglycemic tse thehiloeng ho metformin hydrochloride. Analog ea sehlopha e sebetsang hantle ke Foromo. Moriana ona ke sebaka se setle sa Glidiab.

Theko ea lithethefatsi ke li-ruble tse ka bang 180-260. Foromo e fumaneha ka tekanyetso ea 500 mg, 850 mg le 1 gram. Sephutheloana se le seng se na le matlapa a 60. Sebopeho sa moriana se kenyelletsa metformin hydrochloride, povidone, primellose, magnesium stearate.

Karolo e sebetsang ea formin e sebetsa joang? Litaelo li bontša hore metformin hydrochloride e sitisa tšebetso ea gluconeogenesis bokong, hape e thusa ho fokotsa ho monya ha tsoekere maling.

Hape, karolo e sebetsang e ntlafatsa tšebeliso ea matla a tsoekere, hape e thusa ho eketsa kutloisiso ea lisele tsa kahare ho litlamorao tsa insulin. Tabeng ena, metformin hydrochloride ha e ame ts'ebetso ea ho boloka insulin ka lisele tsa beta, ka lebaka leo monyetla oa ho theha hypoglycemia o fokotsoang.

Ka thuso ea Forthin, mofuta oa tsoekere ea 2 o ka alafshoa. Haholo-holo khafetsa, moriana o sebelisoa ha motho ea nang le lefu la tsoekere a e-na le botenya le maemong ao kalafo ea lijo e sa thuseng ho ntlafatsa boleng ba tsoekere ea mali. Ke rata ho hlokomela hore hangata moriana o sebelisoa hammoho le lithethefatsi tse amanang le litlamorao tsa sulfonylurea.

Mokhoa oa ho nka formin? Tekanyetso ea pele ke 1000-1700 mg ka letsatsi. Ho feta moo, litekanyetso li arotsoe likarolo tse peli. Ho molemo ho sebelisa lipilisi kamora lijo, ho nwa metsi a mangata.

Haeba tsoekere ea mali e sa tsitsa, butle-butle litekanyetso li eketsoa ho ligrama tse 2-3 ka letsatsi. Tekanyo e kholo ea letsatsi le letsatsi ea Formetin ke ligrame tse tharo eseng tse ling. Empa bakuli ba tsofetseng ba khothalletsoa hore ba se ke ba qeta grame e le 'ngoe ka letsatsi.

Contraindication mabapi le ts'ebeliso ea lithethefatsi:

1. Allergy ho likarolo.
2. Mosebetsi o sa sebetseng oa renal, haholo-holo ho hloleha ha rereto.
3. Karolo e mpe ea infarction ea myocardial.
4. Ho omella.
5. Ho hloleha ha pelo kapa ho hema.
6. Ketsahalo ea kotsi ea methapo.
7. Bokhoba ba tahi bo sa feleng
8. Bokhachane le pelehi.
9. Maemo ao ho ona ho nang le tlhokahalo ea tšebeliso ea insulin. E ka ba likotsi tse mpe, ho chesa kapa ho kenella.
10. Lactic acidosis.
11. Ho tsamaellana le lijo tse thata, tse fanang ka phokotso ea likhalori tsa letsatsi le letsatsi ho li-kilocalories tse 1000.
12. Kenya kopo matsatsing a mabeli a ho qetela a lithuto tsa x-ray ka kenyelletso ea ntho e nang le iodine e fapaneng. Ka tsela, moriana ha oa lokela ho jeoa matsatsi a 2 pele ho tlhatlhobo ea X-ray joalo.

Har'a litla-morao tsa lithethefatsi, ho na le ho se sebetse hantle ts'ebetsong ea tšilo ea lijo, ho senyeha hoa metabolic, phokolo ea mali, hypoglycemia le ho hanyetsa. Video e sehloohong sena e tla u bolella hore na meriana ea lefu la tsoekere ke eng.