Isulin insulin

Lebitso la Khoebo la tokiso: Insulin-insophane (insulin-isophan human biosynthetic)

Lebitso le sa nepahalang la machabeng: Insulin + Isofan

Foromo ea boholo: ho emisoa bakeng sa tsamaiso e poteletseng

Lintho tse sebetsang: insulin + isophane

Sehlopha sa Pharmacotherapeutic: insulin e sebetsang ka nako e telele

Ketso ea pharmacological:

Insulin e sebetsang lipakeng. E fokotsa khatello ea tsoekere maling, e eketse ho kenngoa ha eona ka lisele, e ntlafatse polelo ea lipogenis le glycogenogeneis, motsoako oa protheine, o fokotsa sekhahla sa tlhahiso ea tsoekere ke sebete.

E sebetsana le receptor e itseng kahare ho li-membrane tse kantle tsa lisele mme e etsa mochini o amohelang insulin. Ka ho kenya ts'ebetso ea cAMP (liseleng tse mafura le lisele tsa sebete) kapa ho kenella ka ho toba ka seleng (mesifa), motsoako oa insulin o hlohlelletsa lits'ebetso tse kenang kahare, ho kenyeletsa synthetise ea li-enzymes tse 'maloa tsa bohlokoa (hexokinase, pyruvate kinase, glycogen synthetase, jj.). Ho fokotseha ha tsoekere maling ho bakoa ke keketseho ea lipalangoang tsa eona tse makatsang, ho monya ho eketsehileng le ho ts'oaroa ha lisele, ho hlohlelletsoa ha lipogenesis, glycogenogeneis, synthetiki ea protheine, ho fokotseha ha sekhahla sa tlhahiso ea tsoekere ke sebete (ho fokotseha ha ho phatloha ha glycogen), jj.

Kamora ho entetsoa ka sc, phello e etsahala ka lihora tse 1-1.5 Phello e kholo e pakeng tsa lihora tse 4 ho isa ho tse 12, nako ea tšebetso ke lihora tse 11- 24, ho ipapisitse le sebopeho sa insulin le lethal dose, se bonts'ang liphapang tse kholo tsa kahare le tsa motho ka mong.

Matšoao a sebeliso:

Type 1 lefu la tsoekere.

Mofuta oa lefu la tsoekere la mofuta oa 2, sethala sa ho hanana le lithethefatsi tse tsoang ka molomo (hypoglycemic drug), ho hanyetsa ka hanyane lithethefatsing tsa kalafo ea molomo (mafu a kopaneng), mafu a tšoaetsanoang, ts'ebetso ea bongaka (ts'ebetso ea motsoako kapa motsoako), lefu la tsoekere ka nako ea boimana (ka kalafo e sa sebetseng).

Contraindication:

Hypersensitivity, hypoglycemia, insulinoma.

Tekanyetso le tsamaiso:

P / C, makhetlo a 1-2 ka letsatsi, metsotso e 30-45 pele ho lijo tsa hoseng (fetola sebaka sa ente nako le nako). Maemong a ikhethang, ngaka e ka fana ka ente ea / m ea moriana. Ho / ts'ebetsong ea insulin ea nako e mahareng e thibetsoe! Methapo e khethoa ka bonngoe 'me ho ipapisitse le litaba tsa glucose maling le moroto, litšoaneleho tsa lefu lena. Ka tloaelo, tekanyetso ke 8-25 IU 1 nako e le ngoe ka letsatsi. Ho batho ba baholo le bana ba nang le kutloisiso e phahameng ea insulin, lethal dose le ka tlase ho 8 IU / letsatsi le ka lekana, ho bakuli ba nang le kutloisiso e fokotsehileng - ho feta 24 IU / letsatsi. Ka tekanyetso ea letsatsi le letsatsi e fetang 0,6 IU / kg, - ka mokhoa oa liente tse 2 libakeng tse fapaneng. Bakuli ba fumanang IU ea 100 kapa ho feta ka letsatsi, ha ba nka insulin, ho bohlokoa hore ba sepetlele. Phetisetso ho tsoa ho sethethefatsi se seng ho ea ho se seng e lokela ho etsoa ka tlasa taolo ea tsoekere ea mali.

Litla-morao:

Maemong a tlolo ea molao oa dosing, ho ja, ho ikoetlisa ka matla, maloetse a kopaneng, nts'etsopele ea hypoglycemia e ka etsahala, maemong a matla haholoanyane - a makatsang le a maqeba.

Mohlomong: karabelo ea mefuta-futa, tikoloho - botjha le ho hlohlona, ​​ka kakaretso - karabelo ea anaphylactoid.

Ho sebelisana le lithethefatsi tse ling:

Ka meriana ha a lumellane le tharollo ea lithethefatsi tse ling. Phello ea hypoglycemic e ntlafatsoa ke li-sulfonamides (ho kenyelletsa le lithethefatsi tsa molomo tsa hypoglycemic, sulfonamides), li-inhibitors tsa MAO (ho kenyeletsoa furazolidone, procarbazine, selegiline), li-inhibitors tsa carbonic, anhibitors, li-NSAIDs (ho kenyeletsa le li-salicylates), anabolic (ho kenyelletsa stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, phenfluramine, Li + litokisetso, pyridoxine, quinidine, quinine, chloroine, quinine, chloroine, quinine, etloro. litla Hypoglycemic la litsebeng glucagon, khōlo hormone, corticosteroids, molomo lithibela-pelehi, estrogens, thiazide le sekgoqetsane diuretics, li-hormone BCCI, thyroid, heparin, sulfinpyrazone, sympathomimetics, danazol, tricyclics, clonidine, k'halsiamo ba khahlanong le lōna, diazoxide, morphine e, matekoane, bokoali, phenytoin, epinephrine, H1-histamine receptor blockers.

Beta-blockers, reserpine, octreotide, pentamidine ka bobeli li ka matlafatsa le ho fokolisa phello ea hypoglycemic ea insulin.

Maemo a polokelo ea moriana:

Ka sehatsetsi, ka mocheso oa 2-8 ° C (u se ke oa bata. Qoba hole le bana.

Letsatsi la ho felloa ke nako: Lilemo tse 2

Se ke oa sebelisa kamora letsatsi la ho felloa ke nako le bontšitsoeng ka har'a sephutheloana.

Maemo a ho abjoa ho tsoa litlolong tsa litlama: Ka lengolo la ngaka

Moetsi: ICN Jugoslavija, Yugoslavia