Torvacard: litaelo tsa tšebeliso, matšoao, litlhahlobo le li-analogues

Sehloohong sena, o ka bala litaelo tsa ho sebelisa lithethefatsi Thorvacard. Litlhahlobo tsa baeti ba sebaka - bareki ba moriana ona, hammoho le maikutlo a litsebi tsa bongaka mabapi le tšebeliso ea statv ea Torvacard ts'ebetsong ea tsona li hlahisoa. Kopo e kholo ke ho kenyelletsa maikutlo a hau ka sethethefatsi sena: moriana o thusitseng kapa o sa thusa ho felisa lefu lena, hore na ho bile le mathata afe kapa afe, mme mohlomong a sa phatlalatsoe ke moetsi ho phatlalatso. Li-Analogs tsa Torvacard boteng ba li-analogues tsa sebopeho tse fumanehang. Sebelisa ho theola k'holeseterole le ho thibela mafu a pelo le batho ba baholo, bana, le nakong ea kemaro le ho beleha.

Thorvacard - setlhare se fokotsang lipid sehlopheng sa li-statins. Inhibitor e khethiloeng ea HMG-CoA reductase, enzyme e fetolang 3-hydroxy-3-methylglutaryl-coenzyme A ho mevalonic acid, e leng selelekela sa li-steroid, ho kenyelletsa le cholesterol. Sebeteng, triglycerides le cholesterol li kenyellelitsoe ho VLDL, li kena ka har'a plasma ea mali 'me li tsamaisoa ho lisele tsa thipa. Ho tloha VLDL, LDL e thehoa nakong ea tšebelisano le li-receptor tsa LDL. Atorvastatin (ntho e sebetsang ea lithethefatsi Torvard) e fokotsa plasma cholesterol (Ch) le lipoprotein ka ho thibela ho fokotsoa ha HMG-CoA, e kenyelletsa k'holeseterole ka har'a sebete le ho eketsa palo ea li-receptor tsa LDL bokong bo ka seleng, e lebisang ho ho eketseheng le ho hoholo ha LDL .

Atorvastatin e fokotsa sebopeho sa LDL, e baka keketseho e boletsoeng le e phehellang mosebetsing oa li-receptors tsa LDL. Litekanyetso tsa Torvacard li theola litekanyetso tsa LDL ho bakuli ba nang le homozygous Famal hypercholesterolemia, eo hangata e ke keng ea khoneha ho phekola le baemeli ba bang ba hypolipidemic.

E fokotsa boemo ba cholesterol e felletseng ka 30-46%, LDL - ka 41-61%, apolipoprotein B - ka 34-50% le triglycerides - ka 14-33%, e baka keketseho ea mahloriso a HDL-C le apolipoprotein A. Ho theola ho theola sekhahla sa LDL ho bakuli ba nang le homozygous hereditary hypercholesterolemia, ba hananang le kalafo ka lithethefatsi tse ling tse fokotsang lipid.

Sebopeho

Li-calcium + tsa atorvastatin.

Mofumahali

Ho chona ho phahameng. Lijo li theola sekhahla le nako ea ho amoheloa ha moriana (ka 25% le 9%, ka ho latellana), empa ho fokotseha ha cholesterol ea LDL ho tšoana le ts'ebeliso ea atorvastatin ntle le lijo. Keketseho ea atorvastatin ha e sebelisoa mantsiboea e tlase ho feta hoseng (hoo e ka bang 30%). Kamano ea linear pakeng tsa tekanyo ea ho amoheloa le lethalinyana la lithethefatsi e ile ea senoloa. E tšelisoa haholo-holo ka har'a sebete. E tšeloa kahare ka mpeng ka bile ka mor'a metabolite ea hepatic le / kapa extrahepatic (ha e phatlalatsoe ka ho pheta-pheta ha enterohepatic). Ts'ebetso ea inhibitory Khahlano le HMG-CoA reductase e phehella lihora tse 20-30 ka lebaka la ho ba teng ha metabolites e sebetsang. Ka tlase ho 2% ea tekanyetso ea molomo e behiloe ka har'a moroto. Ha e qhekelloe nakong ea hemodialysis.

Matšoao

• hammoho le lijo ho fokotsa maemo a phahameng a cholesterol e felletseng, cholesterol-LDL, apolipoprotein B le triglycerides le ho eketsa cholesterol-HDL ho bakuli ba nang le hypercholesterolemia ea mantlha, heterozygous ea malapa le hypercholesterolemia e kopaneng (e kopaneng) le mefuta ea 2a le 2a ,
• hammoho le lijo bakeng sa kalafo ea bakuli ba nang le serum triglycerides e phahameng (mofuta oa 4 ho ea ka Fredrickson) le bakuli ba nang le dysbetalipoproteinemia (mofuta oa 3 ho latela Fredrickson), eo kalafo ea hae ea phepo e sa feng phello e lekaneng,
• ho fokotsa maemo a cholesterol e felletseng le LDL-C ho bakuli ba nang le homozygous Famer hypercholesterolemia, ha phekolo ea lijo le mekhoa e meng e sa phekoloeng ea meriana e sa sebetseng ka ho lekana (joalo ka mokhoa oa ho kenyelletsa lipilisi tse fokotsang lipid tse kenyeletsang autohemotransfusion ea mali a hloekisitsoeng a LDL),
• mafu a pelo le methapo ea methapo (ho bakuli ba nang le mabaka a eketsehang a lefu la pelo - ba tsofetseng ho feta lilemo tse 55, ho tsuba, khatello ea maikutlo, lefu la tsoekere, lefu la methapo ea methapo, stroke, leqhubu la methapo ea methapo, protheine / albinuria, lefu la methapo ea methapo ea mali ho beng ka bona ba haufi. ), ho kenyelletsa khahlano le semelo sa dyslipidemia - prophylaxis ea bobeli ka sepheo sa ho fokotsa menyetla e felletseng ea lefu, lefu la myocardial, stroke, ho kenella sepetlele bakeng sa angina pectoris le tlhoko ea ts'ebetso ea ntlafatso.

Lokolla liforomo

10 mg, 20 mg le 40 mg matlapa a koaelitsoeng ka filimi.

Litaelo tsa ho sebelisoa le mekhoa e meng

Pele ho khethoa ha Torvacard, mokuli o lokela ho khothaletsa ho ja lijo tse fokotsang lipid tse ngata, tseo a lokelang ho tsoela pele ho li boloka nakong eohle ea kalafo.

Tekanyetso ea pele ke karolelano ea 10 mg hang ka letsatsi. Tekanyetso e fapana ho tloha ho 10 ho isa ho 80 mg ka letsatsi. Setlhare se ka nooa ka nako efe kapa efe ea letsatsi, ho sa tsotelehe nako ea lijo. Tekanyetso e khethoa ho latela maemo a pele a LDL-C, sepheo sa kalafo le phello ea motho ka mong. Qalong ea kalafo le / kapa nakong ea keketseho ea tekanyetso ea Torvacard, ho hlokahala hore ho be le leihlo la plasma lipid kamora libeke tse ling le tse ling le tse ling tse 2 ho isa ho lekana. Tekanyetso e kholo ea letsatsi le letsatsi ke 80 mg ho tekanyetso e le 'ngoe.

Ho hypercholesterolemia ea mantlha le hyperlipidemia e atileng, maemong a mangata, tekanyetso ea 10 mg ea Torvacard hang ka letsatsi e lekane. Phello e matla ea kalafo e bonoa kamora libeke tse peli, joalo ka molao, 'me phello e phahameng ea kalafo e atisa ho bonoa kamora libeke tse 4. Ka kalafo ea nako e telele, matla ana a phehella.

Litla-morao

• hlooho e bohloko
• asthenia
• ho hloka boroko
• ho tsekela
• ho otsela
• bosiu
• amnesia
• khatello ea maikutlo
• peripheral neuropathy,
• ataxia
• paresthesia
• ho nyekeloa, ho hlatsa,
• ho sokela kapa lets'ollo
• botlaela
• bohloko ba ka mpeng
• ho ipolaisa tlala kapa takatso e matla ea lijo,
• myalgia
• arthralgia,
• myopathy
• myositis
• bohloko ba morao
• o tsitsipane mesifa ea namane,
• letlalo la letlalo le boreleli
• makhopho
• urticaria
• angioedema,
• anaphylactic makala,
• likhohola
• polymorphic exudative erythema, ho kenyelletsa Stevens-Johnson syndrome
• toxic epidermal necrolysis (lefu la Lyell),
• hyperglycemia
• hypoglycemia,
• bohloko ba sefuba
• edema e haufi,
• ho hloka matla
• alopecia
• tinnitus
• boima ba 'mele
• malaise
• bofokoli
• thrombocytopenia
• ho se sebetse hantle ha renal.

Contraindication

• mafu a sebete a sebetsang kapa keketseho ea tšebetso ea li-transaminases ka har'a seramu ea mali (makhetlo a fetang a 3 ha a bapisoa le VGN) a sa tsejoeng,
• ho hloleha ha sebete (ho teba ha A le B ho sekhahla sa bana),
• mafu a lefutso, a joalo ka ho se mamelle lactose, khaello ea lactase kapa malabsorption ea glucose-galactose (ka lebaka la ho ba teng ha lactose sebopeho),
• boimana
• lebone
• basali ba lilemo tsa ho ba le bana ba sa sebeliseng mekhoa e lekaneng ea ho thibela pelehi,
• bana le bacha ba ka tlase ho lilemo tse 18 (ho sebetsa hantle le polokeho ha e thehiloe),
• hypersensitivity ho likarolo tsa moriana.

Bokhachane le pelehi

Torvacard e kopantsoe le kemaro le lactation (matsoele).

Kaha cholesterol le lintho tse kopantsoeng ho tloha ho cholesterol li bohlokoa holima kholo ea masea, kotsi e ka ba teng ea ho thibela ts'oaro ea HMG-CoA e feta molemo oa ho sebelisa lithethefatsi nakong ea kemolo. Ha lovastatin (HMG-CoA reductase inhibitor) e nang le dextroamphetamine e sebelisoa ho trimester ea pele ea kemaro, linyeoe tsa ho beleha bana ba nang le deformation ea masapo, tracheo-esophageal fistula, le anus atresia. Haeba ho ima ho fumanoa nakong ea kalafo le Torvacard, moriana o lokela ho emisoa hang-hang, 'me bakuli ba lokela ho lemosoa ka kotsi e ka bang teng ho lesea.

Haeba ho hlokahala ho sebelisa moriana nakong ea lebese, ha ho fanoe ka monyetla oa liketsahalo tse bohloko ho masea, taba ea ho emisa ho anyesa e lokela ho rarolloa.

Tšebeliso ho basali ba lilemo tsa ho ba le bana e ka etsahala ha feela ho sebelisoa mekhoa e tšepahalang ea ho thibela pelehi. Mokuli o lokela ho tsebisoa ka kotsi e ka bang teng ea kalafo ho lesea.

Sebelisa ho bana

Setlhare sena se kopantsoe hore se sebelisoe baneng le lilemong tsa bocha tse tlasa lilemo tse 18 (botsitso le polokeho ha li so theoe).

Litaelo tse khethehileng

Pele o qala kalafo ea Torvacard, ho hlokahala hore o leke ho fihlela taolo ea hypercholesterolemia ka kalafo e lekaneng ea ho ja, ho ikoetlisa ho matlafatsang mmele, ho fokotsa boima ba 'mele ho bakuli ba nang le botenya le kalafo ea maemo a mang.

Ts'ebeliso ea li-inhibitors tsa HMG-CoA reductase ho fokotsa lipids tsa mali e ka lebisa phetohong ea liparamente tsa biochemical tse bonts'ang mosebetsi oa sebete. Ts'ebetso ea sebete e lokela ho beoa leihlo pele e qala kalafo, libeke tse 6, libeke tse 12 kamora ho qala ho nka Torvacard le kamora ho eketseha ha tekanyetso ka ngoe, hape le nako le nako (mohlala, likhoeli tse ling le tse ling tse 6). Keketseho ea tšebetso ea li-enzyme tsa hepatic ka serum ea mali e ka bonoa nakong ea phekolo le Torvacard (hangata likhoeling tse 3 tse qalang). Bakuli ba nang le keketseho ea litekanyetso tsa transaminase ba lokela ho hlahlojoa ho fihlela maemo a enzyme a khutlela ho tloaelehileng. Ketsahalong eo boleng ba ALT kapa AST bo fetang makhetlo a 3 ho feta VGN, ho khothalletsoa ho fokotsa tekanyetso ea Torvacard kapa ho emisa kalafo.

Phekolo le Torvacard e ka baka myopathy (bohloko ba mesifa le bofokoli bo kopaneng le keketseho ea ts'ebetso ea CPK ka makhetlo a fetang 10 ha e bapisoa le VGN). Torvacard e kanna ea baka keketseho ea serum CPK, e lokelang ho tsotelloa tlhokomelong e khethollang ea bohloko ba sefuba. Bakuli ba lokela ho lemosoa hore ba lokela ho ea ngakeng hang-hang haeba ho ba le bohloko bo sa hlalosoang kapa bofokoli ba mesifa, haholoholo haeba bo tsamaisana le malaise kapa feberu. Phekolo ea Torvard e lokela ho emisoa ka nakoana kapa ho khaoloe ka botlalo haeba ho na le matšoao a monyetla oa myopathy kapa sesosa sa kotsi ea ho ba le ho se sebetse ha masapo ka lebaka la rhabdomyolysis (jk. Ts'oaetso e matla ea methapo, khatello ea methapo, ts'ebetso e matla ea mmele, ts'enyo e kholo ea metabolic, endocrine le electrolyte )

Tšusumetso ho bokhoni ba ho khanna koloi le ho sebetsa ka mekhoa

Litlamorao tse bohloko tsa Torvacard mabapi le bokhoni ba ho khanna makoloi le ho etsa lintho tse ling tse hlokang ho tsepamisa mohopolo le lebelo la karabelo ea psychomotor ha lia tlalehoa.

Ho sebelisana le lithethefatsi

Ka tšebeliso e ts'oanang ea cyclosporine, fibrate, erythromycin ,cacithromycin, lithethefatsi tsa immunosuppression le antifungal tsa sehlopha sa azole, nicotinic acid le nicotinamide, lithethefatsi tse thibelang metabolism e kopantsoeng le CYP450 isoenzyme 3A4, le / kapa ts'ebeliso ea mali ka bongata ba atorvasas tsoha. Ha u fana ka litlhare tsena, melemo le kotsi ea kalafo li lokela ho lekanngoa ka hloko, bakuli ba lokela ho shebeloa khafetsa ho khetholla bohloko ba mesifa kapa bofokoli, haholoholo nakong ea likhoeli tsa pele tsa kalafo le nakong ea ho eketsa tekanyetso ea lithethefatsi life kapa life, nako le nako ho bona ketsahalo ea KFK, leha taolo ena e sa lumelle thibela nts'etsopele ea myopathy e matla. Phekolo ea Torvard e lokela ho khaotsa haeba ho na le keketseho e tšoaileng ea ts'ebetso ea CPK kapa haeba ho na le ho belaelloa kapa ho belaelloa ha myopathy.

Torvacard e ne e se na phello e kholo ea kliniki ka bongata ba khatello ea terfenadine ho plasma ea mali, e hlophisitsoeng haholo ke 3A4 CYP450 isoenzyme, ntlheng ena, ha ho na monyetla oa hore atorvastatin e khona ho ama likarolo tse kholo tsa likarolo tse ling tsa CYP450 3A4 isoenzyme. Ka tšebeliso e tšoanang ea atorvastatin (10 mg hang ka letsatsi) le azithromycin (500 mg hang ka letsatsi), khatello ea li-atorvastatin ka plasma ea mali ha e fetohe.

Ka ho kenella ka nako e le 'ngoe ha atorvastatin le litokisetso tse nang le hydroxides ea magnesium le aluminium, khatello ea li-atorvastatin ka plasma ea mali e fokotsehile ka hoo e ka bang 35%, leha ho le joalo, tekanyo ea ho theoha ha boemo ba LDL-C ha ea ka ea fetoha.

Ka tšebeliso ea nako e tšoanang ea colestipol, meeli ea plasma ea atorvastatin e fokotsehile ka 25%. Leha ho le joalo, phello e fokotsang lipid ea ho kopana ha atorvastatin le colestipol e ne e feta ea lithethefatsi ka bomong.

Ka tšebeliso e tšoanang ea Torvacard ha e ame li-pharmacokinetics tsa phenazone, ka hona, ho sebelisana le lithethefatsi tse ling tse entsoeng ka motsoako o tšoanang oa CYP450 isoenzymes ha hoa lebelloa.

Ha re ithuta ho sebelisana ha atorvastatin le warfarin, cimetidine, phenazone, ha ho na matšoao a tšebelisano-hloko ea bohlokoahali a fumanoeng.

Ts'ebeliso e tšoanang ea lithethefatsi e fokotsang khoholeho ea lihormone tsa endidie (ho kenyelletsa cimetidine, ketoconazole, spironolactone) e eketsa kotsi ea ho theola lihormone tsa endidia tsa steroid (tlhokomeliso e lokela ho sebelisoa).

Ho ne ho se na litšebelisano tse bohloko tsa atorvastatin ka lithethefatsi tse felisang kalafo, hammoho le estrogens.

Ka ts'ebeliso e ts'oanang ea Torvacard ka tekanyo ea 80 mg ka letsatsi le lithibela-pelehi tsa molomo tse nang le norethindrone le ethinyl estradiol, keketseho e kholo ea karolelano ea norethindrone le ethinyl estradiol e ile ea bonoa ke 30% le 20%, ka ho latellana. Tšusumetso ena e lokela ho nahanoa ha u khetha mokhoa oa ho thibela pelehi ka molomo bakeng sa basali ba fumanang Torvacard.

Ka tšebeliso e tšoanang ea atorvastatin ka tekanyo ea 80 mg le amlodipine ka tekanyo ea 10 mg, pharmacokinetics ea atorvastatin e maemong a lekanang ha ea ka ea fetoha.

Ka taolo e khutsitseng ea digoxin le atorvastatin ka tekanyo ea 10 mg, mokokotlo oa tekano ea digoxin ka plasma ea mali ha oa ka oa fetoha. Leha ho le joalo, ha digoxin e ne e sebelisoa hammoho le atorvastatin ka tekanyetso ea 80 mg ka letsatsi, khatello ea "digoxin" e eketsehile ka 20%. Bakuli ba fumanang digoxin hammoho le atorvastatin ba hloka ho hlahlojoa.

Lithuto tsa ho sebelisana le lithethefatsi tse ling ha li e-so tšoaroe.

Li-analog tsa lithethefatsi Torvacard

Analogue ea sebopeho sa ntho e sebetsang:

• Anvistat
• Atocord
• Atomax
• Atorvastatin
• Atorvox
• Atoris
• Vazator
• Lipona
• Lipoford
• Liprimar
• Liptonorm,
• Torvazin
• Tulip.

Analogs sehlopheng sa pharmacological (li-statins):

• Akorta,
• Actalipid
• Anvistat
• Apextatin,
• Atherostat
• Atocord
• Atomax
• Atorvastatin
• Atorvox
• Atoris
• Vazator
• Vasilip
• Zokor
• Zokor Forte
• Zorstat
• Cardiostatin
• Crestor
• Leskol,
• Leskol forte
• Lipobay,
• Lipona
• Lipostat
• Lipoford
• Liprimar
• Liptonorm,
• Lovacor
• Lovastatin,
• Lovasterol
• Mevacor
• Medostatin,
• Mertenil
• Bareki
• Pravastatin,
• Rovacor
• Rosuvastatin,
• Rosucard
• Rosulip,
• Roxer
• SimvaHexal,
• Simvakard,
• Simvacol
• Simvalimite
• Simvastatin
• Simvastol
• Simvor
• Simgal
• Simlo
• Sinkard
• Tevastor
• Torvazin
• Tulip
• Holvasim
• Holetar.

Matšoao a ho sebelisoa

Torvacard 10 mg

Matlapa a behiloeng e le karolo ea kalafo e phethahetseng.Torvacard e sebelisetsoa eng? Moriana o fuoe bakuli ba nang le li-pathologies tse latelang:

• Tabeng ea hypercholesterolemia ea mantlha, hyperlipidemia (lefutso, eseng lefutso mme e kopane), ho fanoa ka lijo nakong ea kalafo e fokotsang cholesterol e felletseng le li-triglycerides (haeba, ho latela sephetho sa tlhahlobo, matšoao ana a eketsehile),
• Ka keketseho ea serum ea mahloriso a triglycerides (mofuta oa 4 hypertriglyceremia ho latela Frederickson), cholesterol e senyehileng le lipoprotein metabolism (abetalipoproteinemia le hypobetalipoproteinemia - dsetalipoproteinemia -
• Ka palo e phahameng ea cholesterol le keketseho ea palo ea lipoprotein tse fokolang tse kopaneng le homozygous Famal hypercholesterolemia,
• Ho se sebetse hantle ha methapo ea pelo (ischemia, lefu la tsoekere, khatello ea mali, ho senyeha ha atherosulinosis, lefu la tsoekere la maoto, lefu la ho senyeha ha pelo),
• Thibelo ea bobeli ea mathata a teng ka mor'a ho kenella ka har'a myocardial infarction, stroke, angina pectoris.

Hape, matlapa a ngoletsoe bakuli ba nang le lebaka la ho ba le lefu la pelo (ho tsuba, lefu la tsoekere, botsofe).

Litaelo tsa ho sebelisa Torvacard le litekanyetso

Nakong ea kalafo, mokuli o tlameha ho latela lijo tsa hypocholesterolemic (thibelo ea letsoai, linaoa, lijo tse mafura, ts'ebeliso ea lijo-thollo, meroho, metsi).

Ho latela litaelo tsa ho sebelisa Torvacard, matlapa a nooa ka botlalo (kahare), ho sa tsotelehe lijo le nako ea letsatsi. Phekolo e etsoa ho latela morero. Litekanyetso tsa pele ke 10 mg (hang ka letsatsi). Ebe palo ea lithethefatsi e eketseha mme, ho ipapisitse le mathata a ramatiki, tekanyetso ea letsatsi le letsatsi e tloha ho leshome ho isa ho mashome a robeli a mg.

Nakong ea kalafo, methapo ea lipid maling e hlahlojoa lilaborator ka mor'a libeke tse ling le tse ling. Sena se lumella phetoho ea litekanyetso tsa nako ka nako.

Likarolo tsa ts'ebeliso ea Torvacard:

- Ka moriana o matla oa lefutso o kopantsoeng le "homozygous", "80 mg",
- Litekanyetso li sa fetoloe haeba ts'ebetso ea ho senyeha ha sebete le a liphio e sa sebetse.
- Phihlelo ea ho fana ka taelo ea ho tloaela bana mosebetsing ha e ea fokola, ka hona, bana ba kenngoa sepetlele nakong ea kalafo (ho qoba karabelo e sa lebelloang ea moriana),
- Bakuli ba tsofetseng ba mamella litafole hantle, kahoo ha ho hlokahale phetoho ea litekanyetso.

Bakuli ba sebelisang litokisetso tsa anticoagulant kapa coumarin, pele ho khethoa ha Torvacard, ba khothalletsoa hore ba hlahlobe PV (nako ea prothrombin). Tlhokomelo e lokela ho nkuoa ha e kopantsoe le HMG-CoA reductase inhibitors le fibrate.

Contraindication le overdose

Matlapa a na le li-contraindication tse ngata, ka hona, o laetsoe ke ngaka kamora tlhahlobo e qaqileng ea mokuli. Ha e khothalletsoe ho phekola Torvacard ka li-pathologies:

• Hypersensitivity ho ntho e ka sehloohong e sebetsang kapa likarolo tse eketsehileng (magnesium oxide, cellcose ea microcrystalline, lactose monohydrate, magnesium stearate),
• Lefu la sethoathoa sa sebete
• Ho eketsa li-enzyme tsa "etiology" tse sa tsejoeng,
• Bana ba ka tlase ho lilemo tse 18 (polokeho, ts'ebetso le ts'ebetso ea mamello ea lithethefatsi ha li e-so theoe ka kliniki), ntle le kalafo ea heterozygous Famal hypercholesterolemia,
• Tsamaiso e tšoanang ea li-proteinase inhibitors (kalafo ea HIV).

Setlhare ha se fuoe basali sethaleng sa ho rala kapa ho emara. Kaha atorvastatin e fetela lebese la matsoele, ha e laeloe nakong ea kemolo.

• ho tsoa ho tsamaiso ea methapo e bohareng - bothata ba ho robala, migraine, ho tsekela, ho sithabela maikutlo, bofokoli ba mesifa,
• ho tsoa ho tšilo ea lijo - ho nyekeloa, ho hlatsa, ho holofala, ho thunya, bohloko ba lehare, ho ruruha ha sebete le manyeme,
• karolong ea tsamaiso ea musculoskeletal - bohloko ba mesifa le bo kopaneng, metabolism e senyehileng ea mesifa ea mesifa (ho fihlela timetsong ea lisele tsa mesifa ea mesifa), ho ruruha ha mesifa.

Hape hoa khoneha nts'etsopele ea maikutlo a ho kulisa - redness ea letlalo, ponahalo ea lekhopho le bobebe, ho hlohlona, ​​ka seoelo - urticaria.
Overdose e etsahala ka lebaka la kalafo e tsoelang pele ea nako e telele kapa khahlano le semelo sa tekanyetso e le 'ngoe. Tabeng ena, mokuli o kena sepetlele, ho fanoa ka phekolo ea matšoao. Hemodialysis ha e sebetse.

Torvakard analogues, lenane

Torvacard, joalo ka lithethefatsi tse ling tse nang le atorvastatin, e hasoa libakeng tsa meriana ntle le taelo. Empa sena ha se bolele ho hang hore mokuli a ka khetha moriana o mong ka boikemelo, o ka ba theko e tlase kapa oa khothatsoa ke setsebi sa meriana.

Haeba matlapa a Torvard a sa lokele mokuli, ngaka e ka fana ka litlhaloso:

Bohlokoa - litaelo tsa ho sebelisa Torvacard, theko le litekanyetso ha li sebetse ho li-analogues ebile li ke ke tsa sebelisoa e le tataiso bakeng sa tšebeliso ea lithethefatsi tsa sebopeho kapa ketso e tšoanang. Litefiso tsohle tsa kalafo li lokela ho etsoa ke ngaka. Ha o khutlisa Torvacard ka analogue, ho bohlokoa ho fumana boeletsi ba setsebi, ho ka hlokahala hore u fetole mokhoa oa phekolo, litekanyetso, joalo-joalo.

Lithethefatsi tsohle li laetsoe ho fokotsa cholesterol e felletseng, lipoprotein tse fokolang le triglycerides ho hypercholesterolemia ea mantlha kapa ea malapa. Li-analog tsa Torvacard le tsona li na le li-contraindication tse ngata, kahoo mokuli o hlahlojoa ka liparamente tsa lipid pele, nakong le ka mor'a kalafo. Litlhahlobo tsa lingaka mabapi le lithethefatsi li ntle: lithethefatsi, joalo ka molao, li mamelloa hantle - litla-morao li ba teng ka seoelo, mme ho bonolo ho li tseba.

Ketso ea pharmacological

E bua ka sehlopha li-statins le lipuo lipid-lowing effect. Inhibits ka mokhoa o ikhethileng le oa tlholisano enzyme e kenyang karolo ea seo k'holeseterole.

Khaled 'me k'holeseterole e fetoha likarolo tsa atherogenic lipoprotein ka har'a sebete, ka mor'a moo mali a fetisetsoa mothapong. Ka ho sebelisana le li-receptors lipoproteinletsoalo le tlase ba fetoha li-lipoprotein tsena.

Ka ho thibela ho fokotsoa HMG-CoA, lipoprotein li fokotsehile 'me k'holeseterole mading. E fokotsehile motsoako oa LDL le tšebetso e eketsehileng ea li-receptor tsa bona.

Setlhare se khona ho fokotsa bongata ba LDL ka homozygous hypercholesterolemia lefutso, ha lithethefatsi tse ling li sena phello.

Moriana o fokotsa cholesterol ka 30-46%, lipoprotein tsa atherogenic ka 41-61%, triglycerides ka 14-33% mme o eketsa se ka hare ho lipoprotein ka antiatherogenic thepa.

Pharmacodynamics le pharmacokinetics

Meleng, khatello e phahameng ea lithethefatsi e etsahala ka nako ea metsotso e 60-120. Ho ja ho fokotsa ho monya, empa hoa fokotseha k'holeseterole bapisoa le seo se se nang lijo. Ha ts'ebetso ea mantsiboea, khatello ea lithethefatsi e tlase ho feta ha e nooa hoseng.

Ka liprotheine tsa mali li tlama ho 98%. E tšelisoa ka har'a sebete ho boptjoa metabolites e sebetsang.

E pepisoa ka bile, halofo ea bophelo ke lihora tse 14. Ho sebetsa hantle ha moriana ho bolokoa ka lebaka la metabolites e sebetsang ho fihlela lihora tse 30. Ka hemodialysis ha e hlahisoe.

Matšoao Torvakard

Matlapa a Torvacard - a tsoa ho eng?

Motsoako o sebelisoa hammoho le lijo bakeng sa:

• fokotsa maemo k'holeseteroleatherogenic lipoproteins, triglycerides, apolipoprotein B le keketseho ea HDL ho hypercholesterolemia, heterozygous mme e kopantseng hypercholesterolemia (mefuta ea Fredrickson IIa le IIb),
• kalafo ea bakuli eo litaba tsa eona li eketsehang triglycerides maling (mofuta oa IV ho ea ka Fredrickson) 'me u thaepe III ho ea ka Fredrickson (dysbetalipoproteinemia), haeba lijo li sa hlahise litholoana,
• fokotsa cholesterol le LDL ka homozygous mofuta oa lelapa hypercholesterolemia,
• kalafo ea maloetse a pelo le a vascular moo ho nang le mabaka a phahameng a ho hlaha hoa lefu la pelo (khatello ea kelello ea methapobakuli ba fetang lilemo tse 55 stroke ho anamnesis, albinuriahypertrophy ea ventricle e ka ho le letšehali, ho tsuba, lefu le poteletseng la vascular,Lefu la pelo ea Ischemic ka lapeng lefu la tsoekere).

Letšoao le tsebahalang haholo bakeng sa Torvacard ke temoso ea bobeli myocardial infarctionlefu revascularizationho hlaseloa ka morao dyslipidemia.

Contraindication

• senya e matla ea sebete,
• boemo bo phahameng transaminase mading
• lefutso la lefutso la tsoekere le lactose, khaello ea lactase,
• basali ba lilemo tsa ho ba le bana ba sa sebelise kemolo,
• boimana le sefuba,
• bana ba ka tlase ho lilemo tse 18
• ho se mamelle motho ka mong.

E sebelisoa ka mokhoa o bonolo bakeng sa mathata a metabolic le metabolic, khatello ea kelello ea methapo, bokhoba ba joalalefu la sebete sepsis, liphetoho lipakeng tsa metsi-electrolyte equilibrium, ka lefu la tsoekere, lefu la sethoathoa, likotsi le lingaka tse kholo.

Litlamorao

Mokhoa oa Alimentary: bohloko ba ka mpeng, dyspepsiaho nyekeloa le pelo le ho hlatsa, mathata a setuloana sa mokokotlo, liphetoho takatso ea lijo, pancreatitis le hepatitis, jaundice.

Sistimi ea musculoskeletal: bohloko manonyeletsong le mesifa, mokokotlong, mesifa ea mesifa ea maoto. myositis.

Ts'ebetso ea Laborator: liphetoho tsa maemo tsoekerets'ebetso ea eketseha li-enzyme tsa sebete le creatine phosphokinase mading.

Liponahatso tse ling li ka kenyelletsa edema ea "tishu" ea sefuba, bohloko ba sefuba, tinnitus, ho hlama, bofokoli, boima ba 'mele, ho hloka matla, ho hloleha ha rems ea mofuta oa bobeli, ho fokotseha ha palo ea liplatelete.

Lipilisi tsa Cholesterol maemong a mang ho lebisitsoe ho khatello ea maikutlo, tlolo ea ts'ebetso ea thobalano, maemong a sa tloaelehang a senya lithapo tse amanang le matšoafo, lefu la tsoekere (Nts'etsopele e ipapisitse le maemo a kotsi - tsoekere e potlakileng, khatello ea methapo ea mali, index ea boima ba 'mele, hypertriglyceridemia).

Litaelo tsa ho sebelisa Torvacard (Mokhoa le litekanyetso)

Nakong ea kalafo, mokuli o lokela ho latela lijo tse fokotsang lipid.

Phekolo e qala ka 10 mg ka letsatsi, kamora moo e nyolohetse ho 20 mg. Tekanyetso ea letsatsi le letsatsi ea kalafo e tsoa ho 10 ho isa ho 80 mg. Tekanyetso e khethoa ho latela melao ea laboratori le litšobotsi tsa motho ka mong.

Moriana o nooa ho sa tsotelehe lijo.

Pele o nka mme, haeba ho hlokahala, ho fetola tekanyetso, tlhahlobo ea laboratori ea maemo a lipid e etsoa.

Matla a kopo a hlaha kamora matsatsi a 14.

Bakeng sa kalafo ea bakuli ba nang le homozygous hypercholesterolemia e 'ngoe ea lithethefatsi tse' maloa tse fanang ka phello ke Torvacard, litaelo tsa ts'ebeliso e hlakileng ea tekanyetso ea letsatsi le letsatsi, e leng 80 mg.

Tšebelisano

Ts'ebeliso ea lithethefatsi tse thibelang metabolism e kopantsoeng le enzyme ea CYP450, erythromycinantifungal le immunosuppress, lithaelese, cyclosporine, clarithromycin, nicotinamide, nicotinic acid mahlaseli a Torvacard maling a eketseha. Ka nako e ts'oanang, monyetla oa myopathy o eketsehile, ka hona ho hlokahala ho laola boemo ba CPK maling.

Ho amoheloa ha chelete ka aluminium hydroxide kapa magnesium e fokotsa khatello ea maikutlo ea Torvacard, empa sena ha se ame ts'ebetso.

Ho kopana le colestipol e fokotsa khatello ea maikutlo atorvastatinempa ba kopaneng lipid-lowing effect e feta e mong le e mong.

Kamohelo lithibela-pelehi tsa molomo le lethalinyana la letsatsi le letsatsi la Torvacard 80 mg le eketsa litaba ethinyl estradiol mading.

Sebelisa hammoho le digoxin e fokotsa khatello ea maikutlo ka 20%.

Litaelo tse khethehileng

Pele ho kalafo, o hloka ho leka ho theola cholesterol ka phepo, kalafo botenya le mafu a kopaneng, ho eketsa ho ikoetlisa.

Nakong ea kalafo, hoa hlokahala ho laola boemo ba AST le ALT. Lekhetlo la pele, taolo e etsoa pele, kamora libeke tse 6 le likhoeli tse 3 kamora ho qala kalafo, le kamora ho fetola tekanyetso le hang ka likhoeli tse ling le tse ling tse tšeletseng. Haeba boemo ba li-enzyme bo nyoloha ka makhetlo a fetang a 3, lithethefatsi li felisitsoe.

Ho ja metsi a Torvacard ho ka baka bofokoli ba mesifa le bohloko (myopathies) le keketseho ea CPK maling. Haeba u na le bohloko ba mesifa kapa bofokoli bo tsamaisana le feberu, u lokela ho etela ngaka.

Moriana o hlakotsoe kotsing ea ho se sebetse hantle ha masapo rhabdomyolysis. E ka ba khatello ea maikutlo, ts'ebetso e pharaletseng, ho leka-lekana ha metabolic le electrolyte, hypotension ea methapots'oaetso e matlacramps.

Ho nona ha Torvacard ho ka lebisa tlhabong lefu la tsoekere ho bakuli ba nang le kotsi e eketsehileng. Empa ho bohlokoa ho hopola hore melemo ea ho nka li-statins e phahame ho feta kotsi ea lefu la tsoekere, ka hona ha ho na tlhoko ea ho hlakola lithethefatsi, 'me bakuli ba kotsing ba lokela ho lula ba behiloe leihlo ke ngaka.

Tlhahlobo ho Torvakard

Litlhahlobo tseo tsa Torvacard tse fumanehang liforomong li re lumella ho etsa qeto ea hore moriana o sebetsa hantle. E laetsoe haholo ke litsebi tsa pelo ho ea maemong a tlase. k'holeseterole le ho sireletsa bakuli ho stroke le lefu la pelo. Kamora ho sebelisoa ha likhoeli tse 1-2, ho fokotseha ho hoholo hoa maemo a cholesterol. Basali ba bang ba bontša litla-morao tse monate - ho theola boima ba 'mele.

Har'a mefokolo e ka bitsoa taba ea hore mori oa k'holeseterole o ka baka ho hloka boroko le ho hlohlona lekhopho la mmele.

Sebopeho, mofuta oa meriana le theko

Ho matlapa a convex, a koahetsoeng ka filimi, a na le letsoai la khalsiamo ea atorvastatin ka boholo ba 10, 20 kapa 40 g. Tlatsetsa ntho ea mantlha:

1. Microcrystalline le hydroxypropyl cellulose,
2. Magnesium oxide le stearate,
3. Sodium ea Croscarmellose
4. Lactose mahala
5. Hypromellose,
6. Silica
7. Tekanyetso ea titanium
8. Macrogol 6000,
9. talcum phofo.

Lithethefatsi tse fanoang ke ngaka. Bakeng sa Torvacard, theko e ka har'a k'hothone ea meriana e itšetlehile ka litekanyetso le boholo ba tsona ka lebokoseng, ka mohlala, Torvacard 20 mg, theko ke matlapa a 90. -1066 rub.

• 10 mg, li-pcs tse 30. - li-ruble tse 279,
• 10 mg, li-pcs tse 90. - li-ruble tse 730,
• 20 mg, li-pcs tse 30. - 426 rub,
• 40 mg, li-pcs tse 30. - li-ruble tse 584,
• 40 mg, li-pcs tse 90. -1430 rub.

Moriana o loketse ts'ebeliso ea lilemo tse 4, ha ho maemo a ikhethang bakeng sa polokelo ea ona a hlokahala.

Pharadodynamics

Sethethefatsi sa maiketsetso Torvacard se thibela ho fokotsoa ha HMG-CoA, ho fokotsa tekanyetso ea syntlete ea cholesterol. Cholesterol, triglycerides, lipoprotein li tsamaisong ea potoloho ea mali.

Litaba tse phahameng tsa k'holeseterole e felletseng (OH), LDL le apolipoprotein B ke eona e bakang kotsi ea atherosulinosis le mathata a eona, boemo bo lekaneng ba HDL bo fokotseha, ho fapana le hoo, matšoao ana.

Litekong tsa liphoofolo, ho ile ha fumaneha hore statin e fokotsa khatello ea k'holeseterole le LP, e thibela HMG-CoA reductase le ho hlahisa cholesterol. Palo ea li-cholesterol receptors tse "mpe" e ntse e eketseha, e ntlafatsa ho kenngoa ha mofuta ona oa lipoprotein. Fokotsa atorvastine le LDL synthesis.

Torvacard e thusa ho fokotsa palo ea lihotele tse ho OS, VLDL, TG, LDL, esita le ho bakuli ba nang le mofuta oa mofuta oa lelapa o seng mofuta oa lelapa, dyslipidemia, hangata ba arabelang litlhare tse ling.

Ho na le bopaki ba kamano e haufi ka kotloloho lipakeng tsa lefu ka methapo ea pelo le methapo ea mali le litaba tsa LDL le OH le mokhoa o tšoanang oa HDL.

Torvacard le metabolites ea eona li sebetsa 'meleng ka meriana. Sebaka se ka sehloohong sa boiphihlelo ba bona ke sebete, e etsang mosebetsi oa ho kopanya cholesterol le tumello ea LDL. Ha e bapisoa le litaba tsa sethethefatsi sa litekanyetso, litekanyetso tsa Torvacard li lumellana ka mafolofolo le ho fokotseha ha maemo a LDL.

Tekanyetso e le 'ngoe e khethoa ho latela sephetho sa karabelo ea kalafo.

Mofumahali

1. Suction. Setlhare se kenella ka mokhoa o hlakileng kahare ho tšilo ea lijo ka mor'a ts'ebeliso ea kahare, ho fihlela sefutho se phahameng ka ho fetisisa ho feta hora e le 'ngoe ho isa ho tse peli. Boemo ba ho monya bo eketseha ka tekanyetso e ntseng e eketseha ea Torvacard. Bioavailability ea eona e ho 14%, boemo ba ts'ebetso ea inhibitory khahlano le HMG-CoA reductase ke 30%. Tšoaetso ea bioavailability e tlase e hlalosoa ka ho hlaka esale pele kemisong ea tšilo ea lijo le biotransformation sebeteng. Lijo li boloka lebelo la ho amoheloa ha lithethefatsi, empa lijo tse arohaneng kapa tse kopaneng ha li ame ho theoha ha cholesterol e mpe. Haeba u sebelisa statin mantsiboea, mahloriso a eona a fokotsehile ka 30%, empa ho se atlehe hona ha ho ame phokotso ea boemo ba cholesterol e "mpe".
2. Tsamaiso. Ho feta 98% ea ntho e sebetsang e tlama liprotheine tsa mali. Liteko mabapi le likhoto li bonts'a hore moriana o ka fetela lebeseng la matsoele.
3. Metabolism. Setlhare sena se na le metabolism e ngata. Ekaba 70% ea ts'ebetso ea eona ea thibelo khahlano le HMG-CoA reductase e fanoa ke metabolites.
4. Ho tsala. Boholo ba atorvastine le lihlahisoa tsa eona li tlosoa ka bile kamora ho sebetsoa ka har'a sebete. Nete ​​ea bophelo ba statin e nka lihora tse 14. Kamora ho nka tekanyetso, eseng ho feta 2% ea moriana o kenang ka har'a moroto.
5. Likamano tsa botona le botšehali. Ho batho ba phetseng hantle ba lilemo tse holileng, liperesente tsa litaba tsa statin li phahame ho feta ho batho ba bacha, ka hona, tekanyo ea ho fokotsoa ha litekanyetso tsa LDL e kholo haholo. Ho basali, litaba tsa Torvacard maling li phahame, empa ntlha ena ha e ame sekhahla sa phokotseho ea LDL. Ha ho na bopaki ba karabelo ea bana ho Torvacard.
6. Psychology Ho hloleha ka molomo ha ho ame maemo a lipalo tsa statin mme ha ho hloke phetoho ea tekanyetso. Ho hlakisoa ha moriana ho ke ke ha ntlafatsa hemodialysis, hobane atorvastine e tlameletsoe ka thata liprotheine.
7. Maloetse a Hepatic. Maloetse a sebete a amanang le tšebeliso e mpe ea joala a na le litlamorao ho sethethefatsi se maling: liteng tsa sona se eketsehile haholo.

Ho lumellana ha Torvacard le meriana e meng

Tlhahisoleseling e hlahisitsoeng e le phetoho makhetlo a mangata ke karolelano ea linyeoe tsa tšebeliso e tšoanang ea lithethefatsi le Torvacard feela.

Tlhahisoleseling e bontšitsoeng karolelanong ea liperesente ke phapang ea data mabapi le ts'ebeliso ea Torvacard ka thoko. AUC - sebaka se ka tlasa sekoaelo se bonts'a boemo ba atorvastatin ka nako e itseng. C max - lethathamo la lintho tse phahameng ka ho fetisisa maling.

Mekhoa ea litlhare bakeng sa tšebeliso le litekanyetso

DosePhetoho ea AUCFetola C _max Cyclosporin 520 mg / 2r. / letsatsi, khafetsa.10 mg 1 p./day bakeng sa matsatsi a 288.7 leq.10.7 r Saquinavir 400 mg 2 p./day / Ritonavir 400 mg 2 p./day, matsatsi a 1540 mg 1 p./day bakeng sa matsatsi a 43.9 leq.4,3 leq. Telaprevir 750 mg ka mora lihora tse 8, matsatsi a 10.20 mg RD7.88 leq.10.6 leq. Itraconazole 200 mg 1 leq. / letsatsi, matsatsi a 4.40 mg RD.3.3 leq.20% Clarithromycin 500g 2 r./day, matsatsi a 9.80 mg 1 leq Bakeng sa matsatsi a 84,4 r5.4 leq. Fosamprenavir 1400 mg 2 p./day, matsatsi a 14.10 mg hang ka letsatsi bakeng sa matsatsi a 4.2.3 leq.. 4.04 leq. Lero la morara, 250 ml 1 r. / Letsatsi.40 mg 1 p./day n37%16% Nelfinavir 1250 mg 2 p./day, matsatsi a 1410 mg 1 p./day ka 28 d74%2.2 leq. Erythromycin 0.5g 4 r./day, matsatsi a 7.40 mg 1 p./day51%Ha ho na phetoho Diltiazem 240 mg 1 p./day, matsatsi a 28.80 mg 1 leq15%12% Amlodipine 10 mg, tekanyetso e le 'ngoe10 mg 1 p./day33%38% Colestipol 10 mg 2 p. / Letsatsi, libeke tse 28.40 mg 1 p./day bakeng sa libeke tse 28ha e khetholloe26% Cimetidine 300 mg 1 r./day, libeke tse 4.10 mg 1 p./day bakeng sa libeke tse 2ho fihla ho 1%11% Efavirenz 600 mg 1 r./day, matsatsi a 14.10 mg ka matsatsi a 3.41%1% Maalox TC ® 30 ml 1 r./day, matsatsi a 17.10 mg 1 p./day bakeng sa matsatsi a 1533%34% Rifampin 600 mg 1 p./day, matsatsi a 5.40 mg 1 p./day80%40% Fenofibrate 160 mg 1 p./day, matsatsi a 7.40 mg 1 p./day3%2% Gemfibrozil 0,6 g 2R./day., Matsatsi a 7.40 mg 1 p./day35%ho fihla ho 1% Boceprevir 0.8g 3 r./day, matsatsi a 7.40 mg 1 p./day2.30 leq.2.66 leq.

Kotsi ea lefu la mesifa ea mokokotlo (rhabdomyolysis) e ba teng ha Torvacard e kopana le meriana e eketsang boemo ba eona. Ho kotsi ho e kopanya le cyclosporine, styripentol, telithromycin ,cacithromycin, delavirdine, ketoconazole, voriconazole, posaconazole, itraconazole le thibelo ea HIV.

Hangata, ho khethoa li-analogues tse sa sebetsaneng le Torvacard. Haeba leha ho le joalo ho se ho entsoe qeto ea ho li kopanya, li bala likotsi tsohle le melemo ea kalafo e joalo.

Statins le fusidic acid ha li lumellane: atorvastatin e hlakotsoe bakeng sa thupelo ea acid ea acid.

Haeba mokuli a sebelisa lithethefatsi tse eketsang karolo ea "statin" maling, ho fanoa ka tekanyo e fokolang ea Torvacard. Ho hlahlojoa khafetsa ha bakuli ba joalo hoa hlokahala.

Liphuputso tse ling li re li-statin li ka eketsa tsoekere ea mali haholo. Bakuli ba prediabetes ba ka hloka kalafo ea antidiabetes. Empa haeba u bapisa ts'okelo ena le kotsi ea ho senyeha ha methapo, ts'ebeliso ea li-statins e ka utloahala.

Baemeli ba sehlopha sa kotsi (tsoekere e lapileng ho fihlela ho 6.9 mmol / l, BMI> 30 kg / m2, khatello e phahameng ea triglycerol, khatello ea mali) ba lula ba lekola litekanyetso tsa biochemical le boemo ba bongaka.

Lintho tse ling tse thusang le tsona li ka baka litlamorao tse sa batleheng. Mohlala, lactose ha e lokele ho ts'oaroa ha galactose ka bo eona kapa ka lebaka la ho haella ha lactase.

Bakuli ba nang le lefu la pelo le coronary le bakuli ba kotsing ea ho tšoaroa ke angina pectoris Torvacard e tsamaellanang le lijo.

Torvacard: matšoao le li-contraindication bakeng sa ts'ebeliso

Batho ba baholo ba se nang matšoao a lefu la pelo, empa ka litakatso tsa peleho ea eona (khatello e phahameng ea mali, ho tsuba, lilemo, HDL e fokolang, lefutso la lefutso la pelo), ba fuoe setlhare bakeng sa thibelo ea ho otloa ke lefu la pelo, myocardial infarction, le ho fokotsa kotsi ea ts'ebetso ea revascularization.

Mofuta oa 2 oa lefu la tsoekere ntle le matšoao a lefu la pelo, empa o na le maemo a kotsi a kang retinopathy, albinuria (protheine ka har'a moroto e bonts'ang methapo ea methapo), ho tsuba kapa khatello ea mali, "statin" e laeloa ho thibela lefu la pelo le stroke.

Ka lefu le bohloko la pelo le amang pelo, atorvastatin e laeloa ho thibela lefu la pelo le se nang kotsi le le sa bolaeang, ho tsamaisa ts'ebetso ea revascularization, le ho fokotsa kotsi ea ho kena sepetlele bakeng sa liketsahalo tsa pelo tse bohloko.

Ka hyperlipidemia, moriana oa Tovakard o bontšoa ka ho tšoana le lijo tse fokotsang matšoao a "cholesterol" e mpe le triglycerol ebile e ntlafatsa HDL.

Se ke oa fana ka Torvacard bakeng sa mafu a sebete sethaleng se sebetsang le ho eketsa kutloisiso ea metsoako ea atorvastatin.

Thorvacard nakong ea kemolo

Bakhachane, hammoho le basali ba ka ima, ba se ke ba sebelisa Torvacard, hobane li-statin li kotsi ho lesea. Bakuli ba lilemo tsa ho ba le bana ba lokela ho ikarabella ho khethoeng lithibela-pelehi.

Leha e le moimana ea tloaelehileng, karolo ea cholesterol le triglycerol e phahame ho feta e tloaelehileng. Lithethefatsi tsa Hypolipidemic ntlheng ena ha li na thuso, hobane cholesterol le lihlahisoa tsa eona li hlokahala bakeng sa ho thehoa ka botlalo ha "fetus".

Atherosclerosis ke lefu le sa foleng 'me e se e le teng ka mashome a lilemo, ka hona, nako e khutšoanyane ea renal atorvastine e ke ke ea ama tsela ea hypercholesterolemia.

Bakeng sa Torvakard, lithuto tse mabapi le tšebeliso ea lithethefatsi ho lesea le anyelitsoeng ha li so etsoa. Empa ka kakaretso, li-statin li khona ho kenella ka lebeseng la matsoele, li baka litlamorao tse sa rateheng ho masea. Ka hona, ho bohlokoa hore basali ba nkang Torvacard ba fetisetse ngoana phepelong ea phepo e nepahetseng.

Tekanyetso le tsamaiso

Ka hyperlipidemia le dyslipidemia, tekanyetso ea pele ea lithupelo tsa lithethefatsi tsa Tovakard e khothaletsa nakong ea 10-20 mg / ka letsatsi. Haeba "cholesterol" e mpe e tlameha ho fokotsoa ka 45% kapa ho feta, o ka qala ka 49 mg / ka letsatsi. Meeli e akaretsang ea boholo ba litekanyetso ke 10-80 mg / letsatsi.

Bana ba lilemo tse 10-17 ba nang le heterozygous hypercholesterolemia ba qala thupelo ka 10 mg / ka letsatsi. Tekanyetso e phahameng ea Tovacar e fihla ho 20 mg / ka letsatsi. Ha ho na data ea hore na bana ba itsoara joang ha u bona litheko tse tebileng haholoanyane. Lekola sekhahla ka mor'a libeke tse 'ne kapa ho feta.

Haeba ho na le nalane ea homozygous hypercholesterolemia, lethathamo la litekanyetso tsa Torvacard ke 10-80 mg / letsatsi. Statin e sebelisoa hammoho le lithethefatsi tse fokotsang lipid, hammoho le ha phekolo e joalo e sa fumanehe.

Tlhaloso ea litekanyetso ha e hlokehe ho bakuli ba nang le ho hlleha ha a liphio, hobane li-pathologies tse joalo ha li ame katleho ea atorvastatin.

Taeo ha e khothaletse ho fana ka taelo ea Torvacard ho bakuli ba sebelisang li-virus tsa HIV le hepatitis C, hammoho le cyclosporine.

Thuso ka overdose

Ha ho na kalafo e khethehileng bakeng sa tšebeliso e feteletseng ea Torvacard. Mekhoa e khethoa ho latela matšoao, e tlatselletsang ka mehato e tšehetsang. Ka lebaka la tlamo e potlakileng ea karolo e sebetsang liprotheine tsa mali, motho ha aa lokela ho lebella hore keketseho ea eona e hlakileng ke hemodialysis.

Bakeng sa Thoracard, litaelo tse qaqileng tsa tšebeliso li ka fumanoa mona.

Litlamorao

Litla-morao tse bohloko tse fumanoeng ho 2% tsa bakuli ba noang litekanyetso tse fapaneng tsa Torvacard, ho sa tsotelehe sesosa, li hlahisoa ka har'a tafole.

Atorvastatin ha e ame haholo boemo ba tlhokomelo le ho arabela ha o sebetsa ka mekhoa kapa tsamaiso ea lipalangwang.

Torvacard - analogues

Meriana e nang le thepa e tšoanang e ka kenyelletsa atorvastatin kapa e na le mesebetsi e ts'oanang ea tšusumetso 'meleng. Pele u nka qeto ea ho fetohela mokhoa o mong oa kalafo, o lokela ho buisana le ngaka kamehla.

Bakeng sa motsoako o sebetsang, o ka khetha mofuta oa li-analogs tsa Torvakard tse theko e phahameng haholo le tse theko e tlaase:

• Atomax
• Anvistata
• Atoris
• Liptonorm,
• Lipona
• Liprimara,
• Lipoford
• Tulipa.

Ho latela liphetho tsa phello 'meleng, Torvacard e ka nkeloa sebaka:

• Avestatin,
• Acortoy
• Apextatin,
• Aterostat,
• Vasilip,
• Zovatin,
• Zorstat
• Zokor,
• Cardiostatin
• Ka sefapano
• Leskol,
• Lovastatin
• Mertenil,
• Rosuvastatin,
• Roxeroi
• SimvaHeksalom,
• Simlo
• Simgal
• Simvakardom.

Pele u nka Torvacard kapa statin e 'ngoe, ho bohlokoa ho ithuta litaelo tsa tšebeliso, ho sebetsana le litlamorao le ho tsamaellana le lithethefatsi tse ikemetseng.