Actovegin® (Actovegin®)

matlapa a koahetsoeng.

Letlapa le 1 le koahetsoeng le na:
Kernel: ntho e sebetsang: dikarolo tsa madi: hemoderivative ea mali a namane - 200.0 mg ka sebopeho sa Actovegin ® granrate * - 345.0 mg, Baeti: magnesium stearate - 2.0 mg, talc - 3.0 mg,
Shell: acacia gum - 6.8 mg, glycol wax - 0,5 mg, phthalate ea methapo - 29.45 mg, diethyl phthalate - 11.8 mg, dae quinoline e aluminium varnish - 2.0 mg, macrogol-6000 - 2 95 mg, povidone-K 30 - 1.54 mg, sucrose -52.3 mg, talc - 42.2 mg, titanium dioxide - 0,86 mg.
* Actovegin ® granrate e na le: ntho e sebetsang: Likarolo tsa mali: hemoderivative ea mali a namane - 200.0 mg, li-excipients: povidone-K 90 - 10,0 mg, cellulose ea microcrystalline - 135.0 mg.

matlapa a pota-potileng a biconvex, a tlotsitsoeng ka khetla ea 'mala o botala bo bosehla, bo benyang.

Ketso ea pharmacological

Pharadodynamics
Actovegin ® ke antihypoxant e nang le mefuta e meraro ea litlamorao: metabolic, neuroprotective le microcirculatory. Actovegin ® e eketsa ho amoheloa le ho sebelisoa ha oksijene, eo e leng karolo ea inositol phospho-oligosaccharides, e amang hantle sephethephethe le ts'ebeliso ea tsoekere, e lebisang ntlafatsong ea metabolism ea matla ea lisele le ho fokotseha ha sebopeho sa lactate tlasa maemo a ischemic.

Mekhoa e mengata ea ts'ebetso ea ts'ebetso ea methapo ea methapo e nkoa.

Actovegin ® e thibela nts'etsopele ea apoptosis e susumetsoang ke amyloid beta peptide (AP25-35).

Actovegin modulates tšebetso ea nyutlelie kappa B (NF-kB), e phethang karolo ea bohlokoa ho regulation ea apoptosis le ho ruruha ho tsamaiso ea methapo ea methapo e bohareng le e poteletseng.

Mokhoa o mong oa ts'ebetso o amahanngoa le mofuta oa enzyme poly (ADP-ribose) -polymerase (PARP). PARP e bapala karolo ea bohlokoa ho bonoeng le ho lokiseng tšenyo ea DNA e nang le mathata a mangata, leha ho le joalo, ts'ebetso e feteletseng ea enzyme e ka baka lefu la lisele maemong a kang lefu la cerebrovascular and diabetesic polyneuropathy. Actovegin ® e thibela ts'ebetso ea PARP, e lebisang ntlafatsong e sebetsang le morphological ea boemo ba tsamaiso ea methapo ea methapo le bohlaba-phio.

Litlamorao tse ntle tsa Actovegin ® e amang microcirculation le endothelium ke keketseho ea phallo ea mali a "capillary", ho fokotseha ha sebaka sa pericapillary, ho fokotseha ha molumo oa methapo ea methapo ea methapo le methapo ea methapo ea mali, phokotseho ea phallo ea mali le methapo ea mali. nitric oxide, e amang microvasculature.

Nakong ea lithuto tse fapaneng, ho ile ha fumaneha hore phello ea lithethefatsi Actovegin ® e etsahala kamora metsotso e 30 kamora ho tsamaisoa ha eona. Phello e phahameng e bonoa lihora tse 3 kamora ho ba batsoali le lihora tse 2-6 kamora taolo ea molomo.

Mofumahali
U sebelisa mekhoa ea pharmacokinetic, ho ka se khonehe ho ithuta likarolo tsa pharmacokinetic tsa Actovegin ®, hobane e na le likarolo tsa mmele feela tse atisang ho ba teng 'meleng.

E le karolo ea kalafo e rarahaneng:

• Phekolo ea matšoao a ho senyeha ha kelello, ho kenyeletsa le ho holofala kelellong le ho ba le 'dementia' ea morao-rao.
• Phekolo ea matšoao a ho potoloha ha mali le liphetho tsa tsona.
• Phekolo ea matšoao a lefu la tsoekere la polyneuropathy (DPN).

Litšoantšo tsa 3D

Tekanyetso le tsamaiso

I / O, I / O (ho kenyeletsoa ka mokhoa oa infusion), ka / m.

Mabapi le bokhoni ba kholo ea nts'etsopele ea anaphylactic, ho kgothaletsoa ho etsa liteko bakeng sa ho ba teng ha hypersensitivity ho moriana pele ho qala ts'ebetso.

Mathata a kelello le methapo ea mokokotlo. 5-25 ml (200-1000 mg ea lithethefatsi) ka letsatsi i / v letsatsi le leng le le leng bakeng sa libeke tse peli, e lateloe ke phetoho ea foromo ea letlapa.

Ischemic stroke. 20-50 ml (800-2000 mg ea lithethefatsi) ka 200- 300 di ml ka tharollo ea sodium chloride ea 0,9% kapa 5% iv dextrose tharollo bakeng sa beke 1, ebe 10-20 ml (400-800 mg ea moriana) ) iv drip - Libeke tse peli ka mor'a phetoho ea sebopeho.

Mathata a methapo ea methapo (arterial and venous) le litlamorao tsa tsona. 20-30 ml (800-1200 mg ea moriana) ka 200 ml ea tharollo ea sodium chloride ea 0,9% kapa tharollo ea methapo ea methapo kapa e methapo ea methapo ea letsatsi le letsatsi bakeng sa libeke tse 4.

Lefu la tsoekere la polyneuropathy. 50 ml (2000 mg ea moriana) ka letsatsi ka methati bakeng sa libeke tse 3 ka phetoho e latelang ea foromo ea matlapa - matlapa a 2-3. Makhetlo a 3 ka letsatsi bonyane likhoeli tse 4-5.

Pholiso e fola. 10 ml (400 mg ea moriana) iv kapa 5 ml IM letsatsi le letsatsi kapa makhetlo a 3-4 ka beke, ho latela ts'ebetso ea pholiso. Mohlomong tšebeliso e kopaneng le litekanyetso tsa litekanyetso tsa Actovegin ® bakeng sa tšebeliso ea kantle.

Thibelo le kalafo ea likotsi tsa radiation ea letlalo le li-membrane tsa mucous nakong ea kalafo ea radiation. Tekanyetso e tloaelehileng ke 5 ml (200 mg) iv letsatsi le leng le le leng nakong ea ho pepeseha ha radiation.

Radiation cystitis. Nako le nako, letsatsi le letsatsi, ente ea 10 ml (400 mg) hammoho le kalafo e thibelang likokoana-hloko. Sekhahla sa tsamaiso se ka ba 2 ml / min.

Nako ea kalafo e khethoa ka bonngoe ho latela matšoao le ho teba ha lefu lena.

Litaelo tsa ho sebelisa li-ampoules tse nang le sebaka sa khefu

1. Beha ntlha ea ampoule ka ntlha ea khefu.

2. Tlanya ka bonolo ka monwana mme o tsukutle ampoule, lumella tharollo hore e theole fatše ho tloha ntlheng ea ampoule.

3. Arola ntlha ea ampoule ntlheng e phoso ka ho tloha ho uena.

Fomu ea tokollo

Ho enta, 40 mg / ml.

Tabeng ea tlhahiso le lipakete ho Takeda Austria GmbH, Austria:

2, 5, 10 ml ea moriana ka har'a likhalase tse se nang mebala tsa khalase tse nang le ntlha ea khefu. 5 amp ka 'ngoe. ka polasetiki ea lithupa tsa polasetiki. 1, 2 kapa 5 blacks lipakete ka pakete ea karete. Lithutsoana tse sireletsang tse potolohileng tse nang le mantsoe a holographic le taolo ea pele ea ho bula li tšeloa ka paketeng.

Tabeng ea tlhahiso le / kapa liphutheloana ho LLC Takeda Pharmaceuticals, Russia:

2, 5, 10 ml ea moriana ka har'a likhalase tse se nang mebala tsa khalase tse nang le ntlha ea khefu. 5 amp ka 'ngoe. ka polasetiki ea blister strip e entsoeng ka filimi ea polystyrene kapa filimi ea PVC. 1, 2 kapa 5 blacks lipakete ka pakete ea karete. Lithutsoana tse sireletsang tse potolohileng tse nang le mantsoe a holographic le taolo ea pele ea ho bula li tšeloa ka paketeng.

Moetsi

Moetsi / moqapi / mofani oa taolo ea boleng: Takeda Austria GmbH, Austria.

Art. Peter Strasse 25, 4020 Linz, Austria.

"Takeda Austria GmbH, Austria." Peter-Strasse 25, 4020 Linz, Austria.

Kapa LLC Takeda Pharmaceuticals, 150066, Russia, Yaroslavl, ul. Technopark, 9.

Mohala: (495) 933-55-11, fekse: (495) 502-16-25.

Kapa CJSC Pharmfirema Sotex. 141345, Russia, sebaka sa Moscow, setereke sa masepala sa Sergiev Posad, libaka tsa mahaeng Bereznyakovskoe, pos. Belikovo, 11.

Mohalaleli: (495) 956-29-30.

Setheo sa molao seo lengolo la sona la lengolo la ngoliso le fanoeng: Takeda Pharmaceuticals LLC. 119048, Russia, Moscow, ul. Usacheva, 2, leq. 1.

Mohala: (495) 933-55-11, fekse: (495) 502-16-25.

[email protected], www.takeda.com.ru, www.actovegin.ru

Litefiso tsa bareki li lokela ho romelloa atereseng ea mokhatlo oa molao eo lengolo la ngoliso le fanoeng ka lona: Takeda Pharmaceuticals LLC, Moscow, Russia.

Litla-morao

Khafetsa ea litla-morao e ne e beoa ho latela tumellano ea Lekhotla la Mekhatlo ea Machaba ea Saense ea Bongaka (CIOMS): khafetsa haholo (/1 1/10), hangata (≥ 1/100 ho ® ha e bonts'e litlamorao le ha tekanyetso e le makhetlo a 30 ho 40 ho feta methapo e khothalletsoang hore e sebelisoe bathong Ha ho e-so be le linyeoe tsa overdose e ngata le Actovegin ®.

Litaelo tse khethehileng

Lintlha tsa bongaka
Thutong ea multimenti ea ARTEMIDA, e sa sebetseng, e foufetseng hape e sa laoloe ke sebaka (NCT01582854), e neng e ikemiselitse ho ithuta phello ea kalafo ea Actovegin ® mabapi le ho senyeha hoa kelello ho bakuli ba 503 ba nang le lefu la ischemic, liketsahalo ka kakaretso tsa liketsahalo tse mpe tse mpe le lefu li ne li tšoana ho lihlopha tse peli tsa kalafo. Le ha khafetsa maqhubu a khaohileng a ischemic a ne a le kahara bongata bo lebelletsoeng ho baahi bana ba bakuli, palo e kholo ea linyeoe e tlalehiloe sehlopheng sa Actovegin ® ha e bapisoa le sehlopha sa placebo, empa phapang ena e ne e se ea bohlokoa lipalo. Kamano lipakeng tsa linyeoe tsa khafetsa le setlhare sa ho ithuta ha ea ka ea thehoa.

Sebelisa ho bakuli ba bana
Hajoale, lintlha mabapi le ts'ebeliso ea lithethefatsi Actovegin ® ho bana ha li fumanehe, ka hona ts'ebeliso ea eona sehlopheng sena sa batho ha e khothalletsoe.

Tšusumetso ho bokhoni ba ho khanna koloi le mekhoa e meng
Ha e kentsoe.

Packer / Ho hlahisa Tekanyetso ea Boleng

Takeda G MBH, Jeremane
Lenitzstrasse 70-98, 16515 Oranienburg, Jeremane
Takeda GmbH, Jeremane
Lehnitzstrasse 70-98, 16515 Oranienburg, Jeremane
kapa
"Takeda Austria G MBH", Austria.
Art. Peter Strasse 25, 4020 Linz, Austria
Takeda Austria GmbH, Austria
St. Peter-Strasse 25, 4020 Linz, Austria
kapa
LLC Takeda Lihlahisoa tsa litlama
Russia, 150066, Yaroslavl, ul. Technopark, d.9,
kapa
CJSC Pharmfirema Sotex
Russia, 141345, Setereke sa Moscow,
Setereke sa masepala sa Sergiev Posad,
metseng ea mahaeng Bereznyakovskoe, pos. Belikovo, 11.

Lokolla liforomo le sebopeho

Ampulete e nang le mokelikeli o hlakileng kapa o bosesane o mosehla bakeng sa ente.

Motsoako o sebetsang: amohelang hemoderivative, 40 mg / ml.

E hlahisoa ke dialysis, karohano ea membrane le karohano ea likarolo tsa mali tsa liphoofolo tse nyane, tse feputsoeng lebese feela.

Karolo e 'ngoe: metsi a ente.

E ka hlahisoa ke likhamphani tsa meriana Liteda Austria GmbH (Austria) kapa Takeda Pharmaceuticals LLC (RF). E kenelletsoe ka 2 ml, 5 kapa 10 ml ka mefuteng e mengata ea likhalase tsa khalase ea 5 likhomphutha. liphutheloana tse entsoeng ka polasetiki tse entsoeng ka polasetiki. Lisele tse 1, tse 2 kapa tse 5 tsa li-contour ka lebokoseng la karete.

Setlhare ke sa sehlopha sa li-antihypoxants.

Paketeng e 'ngoe le e' ngoe ea karete ea likarete e lokela ho ba le setikara se chitja se ngotsoeng ka mokhoa oa mongolo oa holographic le taolo ea ho bula ha pele.

Hobane ho laetsoe

Actovegin 40 e kenyelitsoe ho li-regimens tsa kalafo tse rarahaneng:

• mathata a kelello a mefuta e fapaneng ea methapo,
• pherekano ea methapo ea pelo le likotsi tsa pelo.
• peripheral angiopathy,
• lefu la tsoekere
• nchafatso ea mesifa (ho sithabela maikutlo, ho ikoetlisa, liso tsa methapo ea methapo e tlase, jj.),
• litlamorao tsa kalafo ea radiation.

Ntle le moo, ho sebelisoa mofuta ona oa litekanyetso, gastritis e potlakileng, ho ruruha ulcers ea ka mpeng le duodenum.

Actovegin 40 ke karolo ea mofuta o felletseng oa kalafo bakeng sa kotsi ea methapo ea methapo.
Moriana o fuoa lefu la tsoekere.
U sebelisa sebopeho sena sa litekanyetso, li-ulcenum tse sa foleng tsa mala le duodenum lia phekoloa.
Actovegin e sebelisetsoa ho phekola litlamorao tsa kalafo ea radiation.

Mokhoa oa ho nka Actovegin 40

Nako, litekanyetso le li-regimens tsa kalafo li thehiloe ho latela litšobotsi tsa ts'ebetso ea methapo ea methapo. E khethoa ka bonngoe. E laetsoe kahare, kahare le kahare.

Molemong oa kalafo ea methapo ea methapo ea methapo le methapo ea methapo ea methapo ea methapo ea methapo ea methapo ea methapo ea methapo ea methapo ea kutlo, "10-20 ml of iv kapa iv" e kenngoa letsatsi le letsatsi. Ebe, ho latela mofuta oa kalafo, 5 ml iv kapa IM e nang le ts'oaetso e liehang.

A ischemic stroke sethaleng se matla, meriana e ea kenngoa.

Ka ischemic stroke sethaleng se matla, infusions e etsoa. Bakeng sa sena, lithethefatsi (10-50 ml) li eketsoa ho 200-300 ml ea motsoako oa isotonic (5% glucose kapa sodium chloride solution). Kamora sena, mofuta oa kalafo o fetoloa ho nka sebopeho sa moriana oa lipilisi.

Bakeng sa kalafo ea maemo a bakoang ke ho senyeha ha methapo ea boko, setlhare sena se laetsoe iv kapa iv (20-30 ml ea moriana o kopantsoe le 200 ml ea sebopeho sa isotonic).

Ho felisa matšoao a lefu la tsoekere la polyneuropathy, 50 ml iv e kenngoa. Ebe litla-morao tsa kalafo li fetoha ts'ebelisong ea Actovegin matlapeng.

Ka tsamaiso ea / m, ho sebelisoa ho fihla ho 5 ml. Kena butle.

Ho nka moriana oa lefu la tsoekere

E bua ka litlhare tse tlatselletsang ho metabolism. Ka hona, e tlameha ho kalafo e rarahaneng ea lefu la tsoekere.

Moriana oa hlokahala kalafo e rarahaneng ea lefu la tsoekere.

Bongata

Ha ho na linyeoe tsa overdose ea Actovegin.

E sebelisoa kalafo le ho thibela li-hypoxic le mathata a ischemic ea litho le lisele ho bakuli ba amanang le lilemo.

Ho na le monyetla oa lipontšo tse eketsehileng tsa litla-morao.

Ho sebelisana le lithethefatsi tse ling

Ha ho litlamorao tse mpe tsa ho sebelisana le lithethefatsi tse fumanoeng.

E lumellana le mefuta ea phekolo e sebelisitsoeng kalafong e rarahaneng ea ischemic stroke (mohlala, le Mildronate).

Ntle le moo, e sebelisoa haholo mererong e kopaneng le lithethefatsi tse sebelisetsoang ho felisa ho haella hoa venous le placental, kalafong ea thrombosis (mohlala, le Curantil).

Mekhaako e hlokang ho ba hlokolosi

Motsoako le li-inhibitors tsa ACE (Enalapril, Lisinopril, Captopril, jj.) Hammoho le litokisetso tsa potasiamo li hloka tlhokomeliso.

Meetso ea Actovegin ke:

• Vero-Trimetazidine,
• Curantil-25,
• Cortexin
• Cerebrolysin, jj.

Curantil-25 ke analogue ea Actovegin.

Theko Actovegin 40

Lits'enyehelo tse tloaelehileng li latela bongata ba li-ampoules le palo ea tsona ka har'a sephutheloana. Ka hona, mohlala, naheng ea Russia, theko ea Actovegin (ente ea 40 mg / ml ampoules ea li-pcs tse 5 ml.) E fapana ka li-ruble tse 580 ho isa ho 700.

Naheng ea Ukraine, sephutheloana se tšoanang se bitsa chelete e ka bang 310-370 UAH.

Lits'enyehelo tse tloaelehileng tsa lithethefatsi li latela bongata ba li-ampoules le palo ea tsona sephuthelong.

Tlhahlobo ea lingaka le bakuli ho Actovegin 40

Maikutlo a lingaka le bakuli mabapi le tšebeliso, katleho le polokeho lia fapana.

Vasilieva E.V., ngaka ea methapo, Krasnodar

Actovegin ha e na litlamorao ebile e mamelloa hantle. E ka sebelisoa ho monotherapy le ho mefuta e rarahaneng ea kalafo. E khethiloe ke li-pathologies tsa methapo ea methapo le liphoso tsa metabolic. Ke khothaletsa ho boholo ba bakuli ba ka.

Marina, ea lilemo li 24, Kursk

Ba ile ba fana ka ente le marotholi a bokhachane nakong ea bokhachane ho tsitsisa phallo ea mali ka placenta. Ha ho na litla-morao. Kamora kalafo, phallo ea mali e ile ea khutlela ho tloaelehileng, mme mokhathala le ho tsekela ho ile ha nyamela hammoho le bokuli. Ke eletsa basali bohle baimana.

Nefedov I.B., ea lilemo tse 47, Oryol

Leha e le hore sethethefatsi sena se thibetsoe ke FDA (Lefapha la Bophelo le Litšebeletso tsa Sechaba sa US), e sebelisoa haholo Russia le linaheng tsa CIS. Antigen ea kantle ho naha. Ha ke tšepe lithethefatsi, litaelo tsa tsona li bonts'a hore ho ka se khonehe ho lekola thepa ea eona ea pharmacokinetic.

Afanasyev P.F. ngaka ea ultrasound, St. Petersburg

Sesebelisoa se setle sa antihypoxic se bolokang phello ea kalafo bakeng sa likhoeli tse 3-6. Sesebelisoa sena se sebelisoa haholo sepetleleng sa rona ho Setsi sa Lipatlisiso. Ankylosing spondylitis bakeng sa ho felisoa ha matšoao a lefu la letsoalo le amanang le ho ruruha ha methapo ea kutlo, litlamorao tsa ho tetebela le ho lemala ha boko. E thusa ho felisa hlooho ea hlooho, migraines, maikutlo a ho tšoenyeha, ho ntlafatsa ts'ebetso ea kelello, jj.

Matšoao Actovegin ®

E le karolo ea kalafo e rarahaneng:

• ho senyeha ha kelello, ho kenyelletsa ho senyeha le ho lemala ka mor'a lefu la sethoathoa,
• mathata a potoloho ea potoloho le litlamorao tsa eona,
• lefu la tsoekere la polyneuropathy.

Melemo ea litekanyetso

Setlhare se sebelisoa ho / a, in / in (ho kenyelletsa sebopeho sa infusion) le / m.

Ho latela boholo ba setšoantšo sa tleleniki, o lokela ho kenya lithethefatsi ka makhetlo a 10-20 ka letsatsi kapa ka letsatsi, ka nako eo 5 ml ka / ka kapa ka / m butle, letsatsi le letsatsi kapa makhetlo a 'maloa ka beke.

Bakeng sa tsamaiso ea infusion, ho tloha ho 10 ho isa ho 50 ml ea moriana o lokela ho eketsoa ho 200-300 ml ea tharollo ea mantlha (tharollo ea isotonic sodium chloride kapa tharollo ea glucose ea 5%). Sekhahla sa infusion se ka ba 2 ml / min.

Bakeng sa liente tsa v / m, se ke ua sebelisa tse fetang 5 ml ea moriana, o lokelang ho tsamaisoa butle, hobane tharollo ke hypertonic.

Nakong e mpe ea ho otloa hoa ischemic (ho qala ho tloha matsatsing a 5-7) - 2000 mg / letsatsi ka / ho hlohlona ho fihlela infusions tse 20 ka phetoho ea mofuta oa matlapa a 2. Makhetlo a 3 / ka letsatsi (1200 mg / letsatsi). Nako eohle ea kalafo ke likhoeli tse 6.

Ka 'dementia' - 2000 mg / day in / Drip. Nako ea kalafo e fihlile ho libeke tse 4.

Maemong a mathata a potoloho ea potoloho le litlamorao tsa tsona - 800-2000 mg / day in / a or in / in Drip. Nako ea kalafo e fihlile ho libeke tse 4.

A lefu la tsoekere la polyneuropathy - 2000 mg / day iv / Drip ea infusions tse 20 ka phetoho ea mofuta oa matlapa a 3. Makhetlo a 3 / letsatsi (1800 mg / letsatsi). Nako ea kalafo e tsoa ho likhoeli tse 4 ho isa ho tse hlano.

Litaelo tsa ho sebelisa li-ampoules tse nang le sebaka sa khefu

Beha ntlha ea ntlha ea ampoule holimo.

Tlanya ka bonolo ka monwana mme o tsukutle ampoule, lumella tharollo hore e tlohele tlase ho tloha ntlheng ea ampoule.

Ho ts'oara ampoule ka letsohong le le leng mme ntlheng e phahame, ka lehlakoreng le leng, khaola ntlha ea ampoule ntlheng ea phoso.

Contraindication

• hypersensitivity ho lithethefatsi Actovegin ®, lithethefatsi tse tšoanang kapa ba fanang ka litlatsetso,
• pelo e senyehileng,
• pulmonary edema,
• oliguria, anuria,
• ho boloka mokelikeli 'meleng,
• bana le bacha ba ka tlase ho lilemo tse 18.