Plevilox ea lithethefatsi: litaelo tsa tšebeliso

Li-pcs tse 5. - Mabokose (1) - liphutheloana tsa karete.
Li-pcs tse 10 - Mabokose (1) - liphutheloana tsa karete.
Li-pcs tse 10 - Mabokose (2) - lipakete tsa karete.
Li-pcs tse 100 - mekotla ea polasetiki (1) - makotikoti a polymer.
Li-pcs tse 1000 - mekotla ea polasetiki (1) - makotikoti a polymer.
Li-pcs tse 500 - mekotla ea polasetiki (1) - makotikoti a polymer.
7 likhomphutha - Mabokose (2) - lipakete tsa karete.
7 likhomphutha - Mabokose (1) - liphutheloana tsa karete.

Ketso ea pharmacological

Sebaka sa antimicrobial sehlopheng sa fluoroquinolones, se sebetsa ka bactericidal. E sebetsa khahlano le mefuta e fapaneng ea likokoana-hloko tsa gram-positive le gram-negative, anaerobic, acid e thibelang acid le atypical: Mycoplasma spp., Chlamydia spp., Legionella spp. E sebetsa hantle khahlanong le mefuta ea libaktheria e hanyetsanang le beta-lactams le macrolides. E sebetsa khahlano le mefuta e mengata ea likokoana-hloko: gram-positive - Staphylococcus aureus (ho kenyelletsa le lintho tse sa tsotelleng ho methicillin), Streptococcus pneumoniae (ho kenyelletsa le mefuta e hananang le penicillin le macrolides), Streptococcus pyogene (sehlopha A), gram-negative - Haemophilus influenzae le mefuta e seng ea beta-lactamase e hlahisang), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (ho kenyelletsa mefuta e sa hlahiseng beta le e seng beta-lactamase e hlahisang), Escherichia coli, Enterobacter cloacae, atypical Chlamydia pneumonia. Ho ea ka liphuputso tsa in vitro, le ha likokoana-hloko tse thathamisitsoeng ka tlase li tsotella moxifloxacin, leha ho le joalo, ts'ireletso ea eona le ts'ebetso ea eona ea ho phekola tšoaetso ha e e-so thehoe. tse phelang a mob mobile ea HIV: Streptococcus milleri, Streptococcus mitior, Streptococcus agalactiae, Streptococcus dysgalactiae, Staphylococcus cohnii, Staphylococcus epidermidis (ho akarelletsa le mefuta e, methicillin nahanela), Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Staphylococcus simulans, Corynebacterium diphtheriae. Likokoana-hloko tse seng ntle tsa Gram: Bordetella pertussis, Klebsiella oxytoca, Enterobacter aerogene, Enterobacter agglomerans, Enterobacter Intermedius, Enterobacter sakazaki, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, Providencia stuartii. Anaerobic microorganisms: Bacteroides distasonis, Bacteroides eggerthii, Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaornicron, Bacteroides uniformis, Fusobacterium spp, Porphyromonas spp, Porphyromonas anaerobius, Porphyromonas asaccharolyticus, Porphyromonas Magnus, Prevotella spp, Propionibacterium spp, Clostridium perfringens, Clostridium .... ramosum. Likokoana-hloko tsa Atypical: Legionella pneumophila, Caxiella burnettii.

Li-blocks topoisomerases II le IV, li-enzyme tse laolang lintho tsa mantlha tsa DNA, hape li kenelletse phetolelong ea DNA, ho e lokisa le ho etsoang. Matla a moxifloxacin a ipapisitse le khatello ea ona maling le liseleng. Metsotso e fokolang ea bactericidal e batlang e sa fapana le maemo a fokolang a thibelitsoeng.

Mekhoa ea ho hanyetsa mokhoa oa ho hanyetsa, ho kenya penicillin, cephalosporins, aminoglycosides, macrolides le tetracyclines, ha e ame mosebetsi oa antibacterial oa moxifloxacin. Ha ho na khanyetso pakeng tsa moxifloxacin le lithethefatsi tsena. Mokhoa oa nts'etsopele ea plasmid-Mediated hanyane ha oa ka oa bonoa. Liketsahalo tsohle tsa ho hanyetsa li tlase. Liphuputso tsa in vitro li bontšitse hore ho hanyetsa moxifloxacin ho hlaha butle butle ka lebaka la letoto la liphetoho tse latellanang. Ka ho pepesetsoa khafetsa likokoana-hloko tse nang le moxifloxacin maemong a fokolang a thibelitsoeng, matšoao a BMD a eketseha hanyane feela. Ho hanyetsa ka sefapano ho bonoa pakeng tsa lithethefatsi ho tsoa sehlopheng sa fluoroquinolone. Leha ho le joalo, likokoana-hloko tse ling tsa gram-positive le anaerobic tse hananang le fluoroquinolones tse ling li tsotella moxifloxacin.

Mofumahali

Kamora ho tsamaisoa ka molomo, moxifloxacin e kenngoa ka potlako mme e batla e le ka botlalo. Kamora tekanyetso e le 'ngoe ea moxifloxacin ka tekanyetso ea max mg C max maling e fumaneha ka nako ea lihora tse 0.5-4 mme ke 3.1 mg / L.

Kamora ho kenngoa ka mokhoa o le mong ka tekanyetso ea 400 mg bakeng sa 1 h, C max e fihlella qetellong ea infusion mme ke 4.1 mg / l, e tsamaellanang le keketseho ea hoo e ka bang 26% ha e bapisoa le boleng ba letšoao lena ha le nkuoa ka molomo. Ka infusions tse ngata tsa IV ka tekanyetso ea 400 mg bakeng sa hora e le 'ngoe, C max e fapana ka bongata ho tloha ho 4.1 mg / l ho isa ho 5.9 mg / l. Karolelano ea C ss ea 4,4 mg / L e fihlella qetellong ea infusion.

Boaoavailability e felletseng e ka ba 91%.

The pharmacokinetics ea moxifloxacin ha e nooa ka tekanyetso e le 'ngoe ho tloha ho 50 mg ho isa ho 1200 mg, hammoho le tekanyo ea 600 mg / ka letsatsi bakeng sa matsatsi a 10, e mola.

Mmuso oa tekano o fihlelloa nakong ea matsatsi a 3.

Ho ikopanya le liprotheine tsa mali (haholo-holo albin) ke hoo e ka bang 45%.

Moxifloxacin e ajoa ka potlako ho litho le lisele. V d ke hoo e ka bang 2 l / kg.

Ho tsepamisa mohopolo o phahameng oa moxifloxacin, e fetisang e leng plasma, e bōpiloe ka liseleng tsa matšoafo (ho kenyelletsa le alveolar macrophages), ka mucous membrane ea bronchi, mokhoeng oa kahare, liseleng tse bonolo, letlalo le likarolo tse thellang. Ka mokelikeli oa methapo le matheong, moriana o khethoa ka foromo e sa lefelloeng, e senang protheine, pokellong e phahameng ho feta plasma. Ntle le moo, lintlha tse phahameng tsa ntho e sebetsang li hlahisoa ka har'a litho tsa ka mpeng le mokelikeling oa litho tsa botona le botšehali.

Biotransformed ho metsoako e sa sebetseng ea soffo le glucuronides. Moxifloxacin ha e ea biotransformed ke microsomal sebete enzymes ea cytochrome P450 system.

Kamora ho fetela mohatong oa bobeli oa biotransformation, moxifloxacin e nkuoa ho tsoa 'meleng ke liphio le mala, ka bobeli e sa fetoheng' me e le mofuta oa metsoako e meng e sa sebetseng ea sirapo le glucuronides.

E pepesitsoe ka har'a moroto, hammoho le makhopho, a sa fetoloeng le a mofuta oa metabolites e sa sebetseng. Ka tekanyo e le 'ngoe ea 400 mg, hoo e ka bang 19% ha e hlahisoe ntle ho moroto, e ka ba 25% e nang le makhopho. T 1/2 ke hoo e ka bang lihora tse 12.

Matšoao a ho sebelisoa

Tšoaetso ea phepelo ea phefumoloho e kaholimo le e ka tlase: sinusitis e matla, ho mpefala ha lefu la mokokotlo, pneumonia e fumanehang sechabeng, tšoaetso ea letlalo le lisele tse bonolo, mafu a rarahaneng a ka mpeng. tšoaetso e bakoang ke likokoana-hloko tse 'maloa, mafu a rarahaneng a ruruhileng a litho tsa kahare.

Mokhoa oa ho sebelisa: litekanyetso le kalafo

Ka hare kapa ka sebopeho sa infravenous infusion (butle-butle, metsotso e fetang 60) - 400 mg 1 nako ka letsatsi. Letlapa le metsoa le felletse, ntle le ho hlafuna, ho sa tsotelehe lijo. Nako ea kalafo bakeng sa ho mpefala ha lefu la mokokotlo - matsatsi a 5, pneumonia e fumanoeng ke sechaba - matsatsi a 10, sinusitis e matla, tšoaetso ea letlalo le lisele tse bonolo - matsatsi a 7, ka ts'oaetso e rarahaneng ea ka mpeng - ka hare ho matsatsi a 5-14 (iv ka ho fetisetsoa ho tsamaiso ea molomo). , mafu a rarahaneng a ruruhileng ea litho tsa kahare - matsatsi a 14.

Ha ho hlokahale ho fetola mofuta oa litekanyetso ho bakuli ba tsofetseng ba nang le hepatic (sehlopha A, B sethaleng sa bana-Pugh) le / kapa renal (ho kenyelletsa le CC ka tlase ho 30 ml / min / 1.73 sq.m).

Litlamorao

Khafetsa - 1-10%, ka seoelo - 0,1-1%, ka seoelo - 0,01-0.1%.

Ho tsoa ho tsamaiso ea tšilo ea lijo: hangata - bohloko ba ka mpeng, ho nyekeloa (dyspepsia (ho kenyelletsa ho ruruha, ho nyekeloa, ho hlatsa, ho ruruha, lets'ollo), ts'ebetso e eketsehang ea "transaminase" ea "sebete", seoelo - membrane ea mucous ea molomo oa molomo, candidiasis ea mucosa ea molomo. anorexia, stomatitis, glossitis, gamma-glutamintransferase, e sa tloaelehang haholo - gastritis, ho fifatsoa ha leleme, dysphagia, jaundice ea nakoana.

Ho tloha lehlakoreng la tsamaiso ea methapo: khafetsa - ho tsekela, ho opeloa ke hlooho, ka seoelo - asthenia, ho hloka boroko kapa ho akheha, ho tšoha, ho tšoha, ho thothomela, ho se sebetse hantle ka linako tse ling - ho bonahatsa lipono, ho nyenyefatsa, ho phahamisa molumo oa mesifa, ho hokahana ha metsamao, ho ruruha, amnesia, aphasia, khatello ea maikutlo, ho tšoenyeha ka boroko, mathata a ho bua, ho sitisoa ke kelello, khatello ea maikutlo, ho akheha, pherekano, khatello ea maikutlo.

Ho tsoa lithong tsa maikutlo: hangata - phetoho ea tatso, ka seoelo - ho senyeha ha pono, amblyopia, tahlehelo ea maikutlo, tatso ea parosmia.

Ho tsoa ho CCC: ka seoelo - tachycardia, khatello ea mali e phahameng, palpitations, bohloko ba sefuba, ho lelefatsa nako ea Q-T, ka seoelo haholo - ho fokotse khatello ea mali, vasodilation,

Ho tsoa ho sistimi ea ho hema: ka seoelo - bokhutšoanyane ba ho hema, ka seoelo - asthma ea bronchial.

Ho tsoa ts'ebetsong ea musculoskeletal: ka seoelo - arthralgia, myalgia, e sa tloaelehang haholo - bohloko ba morao, bohloko ba leoto, ramatiki, tendopathy.

Ho tsoa ho tsamaiso ea genitourinary: ka seoelo - vagidi candidiasis, vaginitis, ka seoelo - bohloko bo ka mpeng, ho ruruha ha sefahleho, edema ea pherekano, ts'ebetso ea ho hlaka ea renal.

Litla-morao: Ha ho potang - ho potlaka, ho hlohlona, ​​ho sa tloaelehang haholo - urticaria, ho thothomela ha anaphylactic.

Boitšoaro ba lehae: khafetsa - edema, ho ruruha, bohloko sebakeng sa ente, ka seoelo - phlebitis.

Matšoao a laboratori: ka seoelo - leukopenia, keketseho ea nako ea prothrombin, eosinophilia, thrombocytosis, keketseho ea ts'ebetso ea amylase, ka seoelo haholo - ho fokotseha ha khatello ea thromboplastin, ho fokotseha ha nako ea prothrombin, thrombocytopenia, anemia, hyperglycemia, hyperlipidemia, hyperlipidemia, hyperlipidemia, hyperlipidemia, hyperlipidemia, hyperlipidemia. Khokahano le tsamaiso ea lithethefatsi ha e so ka e bonoa: ho eketseha kapa ho fokotseha ha hematocrit, leukocytosis, erythrocytosis kapa erythropenia, ho fokotseha ha bongata ba glucose, Hb, urea, keketseho ea mosebetsi oa alkaline phosphatase.

Tse ling: ka seoelo - candidiasis, ho se khotsofale ka kakaretso, ho fufuleloa.

Litaelo tse khethehileng

Nakong ea phekolo e nang le fluoroquinolones, ho ruruha le ho phatloha ha tendon ho ka hlaha, haholo ho bakuli ba tsofetseng le ho bakuli ba amohelang li-corticosteroids ka nako e tšoanang. Ka lipontšo tsa pele tsa bohloko kapa ho ruruha ha methapo, bakuli ba lokela ho emisa kalafo le ho holofatsa leoto le amehang.

Ho na le khokahano e tobileng lipakeng tsa keketseho ea khoholeho ea moxifloxacin le keketseho ea nako ea Q-T (kotsi ea ho theha li-ventricular arrhythmias, ho kenyelletsa le li-torsades de point). Ka lebaka la sena, lethal dose le khothalletsoang (400 mg) ha lea lokela ho fetisoa mme sekhahla sa infusion se lokela ho potlaka (bonyane metsotso e 60).

Tabeng ea letšollo le matla nakong ea kalafo, moriana o lokela ho emisoa.

Tšebelisano

Li-antacids, liminerale, li-multivitamine li sitisa ho kenngoa (ka lebaka la sebopeho sa li-chelate complexes ka li-cation tsa polyvalent) le ho fokotsa khatello ea moxifloxacin ho plasma (tsamaiso e le 'ngoe e khonahala ka nako ea lihora tse 4 pele kapa lihora tse 2 kamora ho nka moxifloxacin).

Tšebelisano e kopanetsoeng le li-quinolones tse ling e eketsa kotsi ea ho lelefatsa nako ea Q-T.

Hanyane ka hanyane likarolo tsa pharmacokinetic tsa digoxin.

GCS e eketsa kotsi ea tendovaginitis kapa ho phatloha ha tendon.

Tharollo ea infusion e lumellana le tharollo ea sehlahisoa sa litlhare tse latelang: tharollo ea 0,9% le 1 molar NaCl, metsi a ente, tharollo ea dextrose (5, 10 le 40%), 20% xylitol tharollo, tharollo ea Ringer, Ringer-lactate, 10% Aminofusin tharollo. Yonosteril.

Ha e lumellane le tharollo ea NaCl ea 10 le 20%, 4.2 le 8.4% Na bicarbonate tharollo.

Sokolla foromo le sebopeho

Mofuta oa tokollo ea lithethefatsi ke matlapa a koahetsoeng ka filimi. Letlapa le leng le le leng le na le 436.4 mg ea moxifloxacin hydrochloride, e lekanang le 400 mg ea moxifloxacin. Likarolo tse nyane:

• Dae e khubelu ea oxide
• hydroxypropyl methylcellulose,
• magnesium stearate,
• MCC
• sodium hammart
• lactose monohydrate.

Setlhare sena se tšeloa ka har'a lilakane tsa 5, 7 kapa 10 likhomphutha. kapa ka botlolong ea polymer ea li-pcs tse 100, 500 kapa tse 1000. (bakeng sa mekhatlo ea bongaka). Lebokose le ka ba le 1, 2 blisters kapa botlolo e le 'ngoe ea polymer.

Pharadodynamics

Moriana o thibelang likokoana-hloko ke fluoroquinolone mme o na le bactericidal.

Likokoana-hloko tsa grram-negative aerobic li na le tekanyo e fapaneng ea kutlo ea ketso ea moriana.

Karolo ea eona e sebetsang e ama pheta-pheto ea DNA ea likokoana-hloko tse kotsi, ka hona e kenya letsoho ho bolaeng ha bona ka potlako. Li-aerobes tse nang le maikutlo a hlakileng li utloahala ho eona: Staphylococcus aureus, Streptococcus dysgalactiae, Streptococcus mitis, Staphylococcus saprophyticus, Streptococcus agalactiae, Staphylococcus hominis, Haemophilias parainfluenzae, Enterobacter ccelae.

Likokoana-hloko tsa gram-negative aerobic li na le tekanyo e fapaneng ea kutlo ea ketso ea lithethefatsi: Porphyromonas asaccharolyticus, Bacteroides ovatus, Porphyromonas asaccharolyticus, Prevotella spp. Mycoplasma pneumonia, Coxiella bumettii.

Boikutlo bo leka-lekaneng ba lithibela-mafu ke: Stenotrophomonas maltophilia, Burkholdera cepacia, Pseudomonas aeruginosa.

Ho tlalehiloe nyeoe ea ho hanyetsa lithethefatsi tse ling ho tsoa sehlopheng sa fluoroquinolones.

Contraindication

Taelo e hana ho beha moriana maemong a joalo:

• lefu la tsoekere
• lefu la sethoathoa
• letšollo le matla
• ka tlase ho lilemo tse 18
• hypokalemia
• lebone
• boimana

Moemeli oa bactericidal ea tlhokomeliso o lokela ho nkoa ka hepatic pathologies, hypokalemia, methapo ea maikutlo, nako e telele ea QT, pseudomembranous colitis, e kopantsoeng le corticosteroids. Ntle le moo, moriana o lokela ho laetsoa ka hloko ho bakuli ba nang le hemodialysis.

Bongata

Mokuli a ka ts'oaroa ke letsoalo, ho thothomela, lets'ollo, ho hlatsa le ho otsela ha a sebelisa lithibela-mafu tse ngata.

Phekolo e kenyelletsa ho itlhoekisa ka popelong le tšebeliso ea lithethefatsi tse monyang.

Mehato e meng ke matšoao mme e lokela ho etsoa tlasa taolo ea letšoao la ECG. Motsoako oa ntho ena ha o eo.

Ho sebelisana le lithethefatsi

Ha e kopantsoe le moriana, liminerale, li-antacid, li-multivitamine li tla mpefatsa ho monya le ho fokotsa khatello ea plasma.

Ts'ebeliso ea moriana o thibelang likokoana-hloko hammoho le li-quinolones tse ling li lebisa ponahalong ea lipontšo tsa lifoto.

Ranitidine e fokotsa ho monya ha moxifloxacin.

Theko ea litlhare tsa meriana

Litsenyehelo tsa lithibela-mafu li qala ho tloha li-ruble tse 620. bakeng sa matlapa a 5 ka paketeng.

Haeba ho na le li-contraindication ho moriana kapa ho se be teng ha oona kahar'a meriana ka nako ea theko, o ka fana ka khetho ho e 'ngoe ea litlhare tse latelang:

• Maxiflox
• Alvelon-MF,
• Aquamox
• Avelox,
• Moksimak,
• Megaflox,
• Moxigram
• Vigamox
• Moxiflo
• Moxystar
• Moxispenser
• Moxifloxacin Canon,
• Moxifloxacin hydrochloride,
• Moxifloxacin-Optic,
• Moxifloxacin-Alvogen,
• Moxifur
• Simoflox,
• Ultramox
• Moflaxia,
• Heinemox.

Boris Belyaev (urologist), toropo ea Balakovo

Moloko oa bone oa fluoroquinolone o thibelang likokoana-hloko. Tšusumetso e batla e ka lebelloa ho 100%. Litlamorao li fokola haholo. Ke fana ka eona bakeng sa kalafo e rarahaneng ea li-urethritis tsa ka mehla.

Tatyana Sidorova, ea lilemo li 38, toropo ea Dzerzhinsk

Ka thuso ea sethethefatsi sena sa antibacteria, ke ile ka phekoloa mycoplasmosis. Mokhoa o nepahetseng oa litekanyetso tsa meriana - Nako e le 'ngoe ka letsatsi, ha ho sa na pheko ea lefu lena le matšoao a eona. Matla ana a fumaneha ka matsatsi a 8-9 a ho nka moriana.

Kristina Verina, ea lilemo li 25, toropo ea Zelenogorsk

Tleliniking eo, ke ile ka fumana hore ke na le mofuta oa baktheria oa pneumonia, 'me ka mor'a moo ba nkenya sepetlele matsatsi a 10. Ha o fetisetsoa kalafong ea kantle ho kalafo, moriana ona o ne o laetsoe hammoho le doxycycline. Ha ke a bona litla-morao tse bonts'itsoeng litaelong, ho ne ho se na pherekano nakong eohle ea moriana. Hona joale ke hlaphohetsoe ka botlalo 'me ke ikutloa ke thabile.

Vera Ignatyeva, ea lilemo li 34, motse oa Kalach-on-Don

Ha ke kopana le cystitis, ke ile ka qala ho sebelisa Aquamox, empa ka ba le allergy ho eona. Ngaka e ile ea mo nkela sebaka sa plevilox. 'Mele oa ka o ile oa nka moriana ona ka khutso. Boloetse bona bo ile ba felisoa ka libeke tse 1,5 tsa taolo e tloaelehileng ea moriana ka tekanyetso e boletsoeng.

Bokhachane le pelehi

Tšireletseho ea moxifloxacin nakong ea kemolo ha e e-so thehoe.

Tšenyo e kopantsoeng e kopaneng e hlalositsoe ho bana ba phekotsoeng ka lithibela-mafu tse itseng tsa quinolone, empa phello e tšoanang e bakiloeng ke ho pepesehela lesea le sa tsoa hlaha ha e tlalehehe. Boithuto ba liphoofolo bo bontša hore na ho na le chefo kapa che.

Ts'ebeliso ea moxifloxacin nakong ea kemolo e tšoaetsanoa.

Joalo ka lithibela-mafu tse ling tsa quinolone, moxifloxacin e na le phello e senyang kholopolong le kholo ea lithane tsa lefufuru manonong a tšehetsang a liphoofolo tse sa ts'oaneng.

Karolo e nyane ea moxifloxacin e hloekisoa lebeseng la matsoele. Lintlha tse mabapi le ts'ebeliso ea moxifloxacin ho basali nakong ea lebactation le phepo ha li fumanehe.

Tšebeliso ea moxifloxacin ho basali ba anyesang e kopantsoe.

Tlhahiso-leseling ea polokeho

Thutong ea mamello ho lintja, ho ne ho se na matšoao a ho hloka mamello ha u sebelisa moxifloxacin kahare. Kamora ho tsamaisoa ha methapo ea kutlo, liphetoho tsa ts'oaetso li ile tsa bonoa tse amang tishu e bonolo ea periarterial, e bonts'ang hore tsamaiso ea methapo ea moxifloxacin e lokela ho qojoa.

Tekanyetso le tsamaiso

Batho ba baholo

Motsoako oa Plevilox 400 mg (1 letlapa) hang ka lihora tse ling le tse ling tse 24. Nako ea kalafo e latela mofuta oa ts'oaetso, joalo ka ha ho hlalositsoe tafoleng ea 1.

Lethathamo la 1: Tekanyetso le nako ea kalafo ho bakuli ba baholo

Nts'a lihora tse ling le tse ling tse 24

Nako ea b (matsatsi)

Sinus ea baktheria e matla

Bacterial e mpefatsa le ho feta ea bronchitis e sa foleng

Tšoaetso e sa rarahanang ea letlalo le likarolo tsa eona

Tšoaetso e rarahaneng ea letlalo le likarolo tsa eona

Tšoaetso e Rarahaneng ea Intraabdominal

E Bakiloe ke likokoana-hloko tse kaholimo (bona karolo ea "Lipontšo bakeng sa ts'ebeliso").

6 Phekolo e latellanang (hangata le ka molomo) e ka fanoa ka khetho ea ngaka.

Tsamaiso ea methapo e bonahala ha tsela ena ea tsamaiso e loketse haholo mokuli (mohlala, mokuli a ke ke a nka foromo ea litlhare tsa molomo). Ha o fetoha ho tloha ho tsamaiso ea methapo ho ea ho tsamaiso ea molomo, ha ho hlokahale phetisetso ea tekanyetso. Bakuli bao kalafo e qalang ka ho ba kenella ka hare ho moxifloxacin e ka fetisetsoa matlapeng ho latela lipontšo tsa kliniki ka boikemisetso ba ngaka.

Baahi ba Khethehileng

Ho batho ba tsofetseng le ba kulang ba nang le boima bo tlase ba 'mele, ha ho hlokahale phetoho ea litekanyetso.

Moxifloxacin e tšoaelitsoe ho bana le lilemong tsa bocha (

Likarolo tsa ts'ebeliso

Chefo ea ho ikatisa

Ha re ithuta ka phello ea moxifloxacin ts'ebetsong ea ho ikatisa ho litoeba, mmutla le litšoene, ho ile ha pakoa hore moxifloxacin e tšela placenta. Boithuto ho likhoto (ha u sebelisa moxifloxacin ka molomo le ka methapo) le litšoene (ha u sebelisa moxifloxacin ka hare) ha hoa senola phello ea teratogenic ea moxifloxacin le phello ea eona molemong oa kemolo. Ka ts'ebeliso e matla ea moxifloxacin ho mebutla ka tekanyetso ea 20 mg / kg, liphoso tsa masapo li ile tsa bonoa. Lintlha tsena li bapisoa le litlamorao tse tsejoang tsa li-quinolones nts'etsopele ea marapo. Keketseho ea palo ea mafu a fosahetseng ho litšoene le mebutlanyana e ile ea senoloa ka tšebeliso ea moxifloxacin ka litekanyetso tsa kalafo. Litekong, ho bile le phokotso ea boima ba "fetus", keketseho ea ho senyeheloa ke mpa, keketseho e nyane ea nako ea kemaro le keketseho ea ts'ebetso ea tlhaho ea bana ba batona le ba batšehali ha ba sebelisa moxifloxacin, litekanyetso tsa bona li ne li phahame ka makhetlo a 63 ho feta kalafo e khothalletsoang e sebetsang ho batho.

Tšusumetso ho bokhoni ba ho khanna makoloi le tse ling tse ka bang kotsiMechine

Fluoroquinolones, ho kenyeletsa moxifloxacin, e ka lebisa bokhoni bo sa lekaneng ba ho khanna likoloi kapa mekhoa e meng e ka bang kotsi ka lebaka la karabelo ea tsamaiso ea methapo e bohareng.

Litlhokahalo tsa polokeho

Maemong a mang, kamora ts'ebeliso ea pele ea lithethefatsi, hypersensitivity le allergic reaction li ka hlaha. Ke ka seoelo, ts'oaetso ea anaphylactic e ka tsoelang pele ho sokela bophelo ba lefu la anaphylactic, le kamora ts'ebeliso ea pele ea lithethefatsi. Maemong ana, moxifloxacin e lokela ho khaoloa mme mehato ea kalafo e hlokahalang e nkuoa (ho kenyelletsa anti-shock).

Ho tlalehoa hore ho na le lefu la hepatitis e tlatsitseng ka botlalo, le ka 'nang la baka ho se atlehe ha sebete ha sebete, ho kenyeletsa le lefu. Haeba matšoao a ho hloleha ha sebete a hlaha, bakuli ba lokela ho ea ngakeng hang-hang pele ba tsoela pele kalafo.

Haeba karabelo e hlaha karolong ea letlalo le / kapa li-membrous tsa mucous, o boetse o lokela ho etela ngaka hang-hang pele a tsoela pele kalafo. Ts'ebeliso ea lithethefatsi tsa quinolone e amahanngoa le kotsi e ka ba teng ea ho ts'oaroa. Moxifloxacin e lokela ho sebelisoa ka hloko ho bakuli ba nang le mafu a methapo ea methapo e kholo le ka maemo a belaetsang ho kenella ha methapo ea methapo e kholo, ho rera esale pele hore ho na le ho ts'oaroa ka tšohanyetso, kapa ho theola monyako oa ts'ebetso e tsitsipanyang.

Ts'ebeliso ea lithethefatsi tsa antibacterial tse pharalletseng, ho kenyeletsoa moxifloxacin, e amahanngoa le kotsi ea ho ba le pseudomembranous colitis e amanang le ho nka lithibela-mafu. Tlhahlobo ena e lokela ho lula e hopoloa ho bakuli ba nang le lets'ollo le matla nakong ea kalafo le moxifloxacin. Tabeng ena, kalafo e loketseng e lokela ho fuoa hang-hang. Bakuli ba nang le lets'ollo le matla ba kopantsoe le lithethefatsi tse thibelang matla a ka mpeng.

Moxifloxacin e lokela ho sebelisoa ka hloko ho bakuli ba nang le Gravis myasthenia gravis, kaha lithethefatsi li ka mpefatsa matšoao a lefu lena. Nakong ea phekolo e nang le fluoroquinolones, ho kenyelletsa moxifloxacin, haholo-holo ho bakuli ba tsofetseng ba fumanang li-glucocorticosteroids, tendonitis le ho phatloha ha tendon ho ka hlaha. Letšoao la pele la bohloko kapa ho ruruha setsing sa likotsi, setlhare se lokela ho emisoa 'me leoto le amehang le imolohe.

Bakeng sa bakuli ba nang le mafu a rarahaneng a ruruhileng ea litho tsa pelvic (ka mohlala, a amanang le li-tubo-ovarian kapa pelvic abscesses) bao ho bonahatsoang kalafo ea methapo, tšebeliso ea moxifloxacin matlapeng a 400 mg ha e khothalletsoe.

Ha u sebelisa li-quinolones, ho bonoa ka mokhoa oa photosensitivity ho bonoang. Leha ho le joalo, nakong ea boithuto ba pelehi, lithupelo tsa bongaka, le ts'ebeliso ea moxifloxacin ts'ebetsong, ha ho lits'oaetso tsa photosensitivity tse boneng. Leha ho le joalo, bakuli ba fumanang moxifloxacin ba lokela ho qoba khanya ea letsatsi le mahlaseli a kotsi a letsatsi.

Katoloso ea nakoanaQTcle maemo a bophelo a amanang le kliniki

Ho fumanoe hore moxifloxacin e eketsa nako ea QTc ho li-electrocardiogram tsa bakuli ba bang. Nakong ea tlhahlobo ea li-ECG tse fumanoeng e le karolo ea lenaneo la teko ea bongaka, ho lelefatsa nako ea QTc ha ho nka moxifloxacin e ne e le li-millisecond tse 6 ± 26 millisecond, e leng 1.4% ha e bapisoa le boemo ba pele. Ka lebaka la hore bolelele ba nako ea QTc ho basali bo bolelele ho feta ho banna, basali ba ka ba kotsing ea ts'ebetso ea lithethefatsi e lelefatsa QTc. Batho ba baholo le bona ba kotsing ea ho fumana litla-morao tsa lithethefatsi ka nako ea QT.

Tekanyo ea ho lelefatsa nako ea QT e ka eketseha ka bongata ba lithethefatsi, ka hona, tekanyetso e khothalletsoang ha ea lokela ho fetisoa. Ho eketsa nako ea QT ho amana le kotsi e eketsehang ea li-ventricular arrhythmias, ho kenyelletsa polymorphic ventricular tachycardia. Leha ho le joalo, ho bakuli ba lefu la pneumonia ho ne ho se na kamano pakeng tsa khatello ea moxifloxacin maling a mali le ho lelefatsa nako ea QT. Ha ho na bakuli ba 9,000 ba tšoaroang ke moxifloxacin ea neng a e-na le mathata a pelo le lefu tse amanang le ho eketseha ha QT. Leha ho le joalo, ho bakuli ba nang le maemo a rerang ho tloahela ho kopana, tšebeliso ea moxifloxacin e kanna ea eketsa kotsi ea li-ventricular arrhythmias.

Mabapi le sena, tsamaiso ea moxifloxacin e lokela ho qojoa ho bakuli ba nang le nako e telele ea QT, hypokalemia e sa hlophiswang, hammoho le ho ba fumanang lithethefatsi tsa antiarrhasmic tsa sehlopha sa (quinidine, procainamide) kapa sehlopha sa III (amiodarone, sotalol), kaha boiphihlelo ba ho sebelisa moxifloxacin ho bakuli bana manyolo. Moxifloxacin e lokela ho khethoa ka hloko, hobane phello ea tlatsetso ea moxifloxacin e ke ke ea qheleloa ka thoko maemong a latelang:

ho bakuli ba fumanang kalafo e kopanetsoeng le lithethefatsi tse eketsang nako ea QT (cisapride, erythromycin, lithethefatsi tsa antipsychotic, li-antidepressants tsa tricyclic),

ho bakuli ba nang le maemo a rerang ho kopana le kalafo, joalo ka bradycardia ea bohlokoa haholo, ischemia e matla,

ho bakuli ba nang le lefu la ho ferekana kelellong, kaha ho ba teng ha nako ea katiso ea QT ho bona ho ke ke ha qheleloa ka thoko,

ho basali kapa bakuli ba tsofetseng ba ka amehang haholo ka lithethefatsi tse eketsang nako ea QT,

Haeba matšoao a ho thatafala ha pelo a hlaha nakong ea kalafo ka moxifloxacin, o lokela ho khaotsa ho sebelisa lithethefatsi le ho etsa ECG.

Plevilox ea lithethefatsi: litaelo tsa tšebeliso

Plevilox ea lithibela-mafu eu lumella hore u loane le mafu a mangata, e leng lisosa tsa likokoana-hloko tseo e leng likokoana-hloko tse amehang ketsong ea tsona. Leha ho le joalo, moriana o lokela ho laeloa ke setsebi feela, hobane ho iphekola ho ka baka litlamorao tse sa lebelloang.

Plevilox e u lumella ho loantša mafu a mangata, e leng lisosa tsa likokoana-hloko tseo e leng likokoana-hloko tse amehang ketsong ea tsona.

14 Li-analog

Haeba ho na le li-contraindication ho moriana kapa ho se be teng ha oona kahar'a meriana ka nako ea theko, o ka fana ka khetho ho e 'ngoe ea litlhare tse latelang:

• Maxiflox
• Alvelon-MF,
• Aquamox
• Avelox,
• Moksimak,
• Megaflox,
• Moxigram
• Vigamox
• Moxiflo
• Moxystar
• Moxispenser
• Moxifloxacin Canon,
• Moxifloxacin hydrochloride,
• Moxifloxacin-Optic,
• Moxifloxacin-Alvogen,
• Moxifur
• Simoflox,
• Ultramox
• Moflaxia,
• Heinemox.

Boris Belyaev (urologist), toropo ea Balakovo

Moloko oa bone oa fluoroquinolone o thibelang likokoana-hloko. Tšusumetso e batla e ka lebelloa ho 100%. Litlamorao li fokola haholo. Ke fana ka eona bakeng sa kalafo e rarahaneng ea li-urethritis tsa ka mehla.

Tatyana Sidorova, ea lilemo li 38, toropo ea Dzerzhinsk

Ka thuso ea sethethefatsi sena sa antibacteria, ke ile ka phekoloa mycoplasmosis. Mokhoa o nepahetseng oa litekanyetso tsa meriana - Nako e le 'ngoe ka letsatsi, ha ho sa na pheko ea lefu lena le matšoao a eona. Matla ana a fumaneha ka matsatsi a 8-9 a ho nka moriana.

Kristina Verina, ea lilemo li 25, toropo ea Zelenogorsk

Tleliniking eo, ke ile ka fumana hore ke na le mofuta oa baktheria oa pneumonia, 'me ka mor'a moo ba nkenya sepetlele matsatsi a 10. Ha o fetisetsoa kalafong ea kantle ho kalafo, moriana ona o ne o laetsoe hammoho le doxycycline. Ha ke a bona litla-morao tse bonts'itsoeng litaelong, ho ne ho se na pherekano nakong eohle ea moriana. Hona joale ke hlaphohetsoe ka botlalo 'me ke ikutloa ke thabile.

Vera Ignatyeva, ea lilemo li 34, motse oa Kalach-on-Don

Ha ke kopana le cystitis, ke ile ka qala ho sebelisa Aquamox, empa ka ba le allergy ho eona. Ngaka e ile ea mo nkela sebaka sa plevilox. 'Mele oa ka o ile oa nka moriana ona ka khutso. Boloetse bona bo ile ba felisoa ka libeke tse 1,5 tsa taolo e tloaelehileng ea moriana ka tekanyetso e boletsoeng.

Angelina Marinina, ea lilemo tse 44, Vladimir toropo

E ile ea phekoloa ka lipilisi tsena tsa pneumonia. Motsoako o loantšang likokoana-hloko o thusang kapele. Empa, kamora ho sebelisa moriana ona, ke ile ka thaba. Ngaka e itse sena se tloaelehile. Ke ile ka tlameha ho eketsa lino tse fapaneng.

Foromo ea tokollo ea Plevilox

Matlapa a koahetsoeng ka lifilimi a 400 mg, blister ea pakete ea 1,

Matlapa a koahetsoeng ka filimi a 400 mg, blister 7 pakete ea karete ea 1,

Matlapa a koahetsoeng ka lifilimi a 400 mg, blister 10 ea karete ea 1,

Matlapa a koahetsoeng ka filimi a 400 mg, blister 7 pakete ea karete ea 2,

Matlapa a koahetsoeng ka filimi a 400 mg, blister 10 pakete ea karete ea 2,

Litafole tse koahetsoeng ka lifilimi tse 400 mg, mokotla oa polyethylene (sachet) li-100 tse (jar) polymer 1,
Matlapa a koahetsoeng ka lifilimi a 400 mg, mokotla oa polasetiki (sachet) 500 e ka (jar) polymer 1,
Litafole tse koahetsoeng ka lifilimi tse 400 mg, mokotla oa polasetiki (sachet) li-1000 li ka (jar) polymer 1,

Sehlopha sa ATX:

J Liphetoho tsa ts'ebeliso ea methapo

Meriana ea antimicrobial bakeng sa tšebeliso ea kamehla

Li-antibacterials tsa J01M - li-quinolone derivatives

Polelo ea litlhare Plevilox e thathamisitsoeng leqepheng lena la sebaka sa rona sa marang-rang e ka sebelisoa bakeng sa ts'ebeliso ea letsatsi le letsatsi.

Bongata ba meriana

Matšoao: mohlomong ho fokotseha hoa ts'ebetso, ho otsela, ho hlatsa, lets'ollo, ho thothomela hoa mmele ka kakaretso, ho akheha. Phekolo: Lavage ea ka mpeng (ka mor'a lihora tse peli ka mor'a ts'ebeliso e fetisisang), ho shebella, kalafo ea matšoao ka ho lekola ECG. Ha ho na pheko e tobileng .. Ho bohlokoa ho netefatsa hore mokelikeli o lekaneng 'meleng ha o ntse o boloka diuresis tse lekaneng.

Litlhahiso tse khethehileng mabapi le ts'ebeliso ea moriana

Bakeng sa ho fokotsa kotsi ea ho hanyetsa moxifloxacin le ho boloka ts'ebetso ea li-antibacterial agents, moxifloxacin e lokela ho fuoa feela bakeng sa kalafo ea ts'oaetso e bakoang ke lits'oants'o tse amehang ka moriana ona. Nakong ea kalafo, ho hlahlojoa ha ECG hoa hlokahala (ho lelefatsa nako ea QT, ventricular arrhythmias). Tekanyo ea ho lelefatsa nako ea QT e ka eketseha ka bongata ba lithethefatsi, ka hona, tekanyetso e khothalletsoang ha ea lokela ho fetisoa. Ho eketsa nako ea QT ho amana le kotsi e eketsehang ea li-ventricular arrhythmias, ho kenyelletsa le flicker-flutter. Nakong ea phekolo e nang le fluoroquinolones, ho kenyelletsa moxifloxacin, haholo-holo ho bakuli ba tsofetseng ba fumanang li-glucocorticosteroids, nts'etsopele ea tendonitis le rupture ea tendon lia khoneha. Letšoao la pele la bohloko kapa ho ruruha setsing sa likotsi, setlhare se lokela ho emisoa 'me leoto le amehang le imolohe. Tabeng ea letšollo le matla nakong ea kalafo le moxifloxacin, moriana o lokela ho khaotsa le kalafo e nepahetseng e boletsoeng. Maemong a mang, ho ba le mathata a mangata a ho kula a ka ba teng, ho kenyelletsa le ho tsitsipanya hoa bophelo ba anaphylactic. Maemong ana, moxifloxacin e lokela ho khaoloa mme ho hlokahala hore ho sebelisoe basebeletsi ba hlokahalang (ho kenyeletsa antishock): glucocorticosteroids, norepinephrine, antihistamines. Moxifloxacin ha e na thepa ea ho nka lifoto. Leha ho le joalo, bakuli ba fumanang moxifloxacin ba lokela ho qoba khanya ea letsatsi le mahlaseli a kotsi a letsatsi. Leha taba ea hore moxifloxacin e bakoa haholo ke ts'usumetso e mpe ho tsoa ho tsamaiso ea methapo e kholo, bakuli ba lokela ho tseba karabelo ea bona ho moriana ona pele ba khanna mochini / mochine o tsamaeang.