Letlapa la Zokor forte: litlhahlobo tsa mokuli le lipontšo tsa ts'ebeliso

E fumaneha ka mokhoa oa litafole, tse koahetsoeng. Matlapa a 10 mg simvastatin, o na le 'mala o mopinki o bobebe, o boreleli sebopeho ka lehlakoreng le leng, ka lehlakoreng le leng ho na le mongolo o ngotsoeng "MSD 735«.

Matlapa a 20 mg simvastatinba le 'mala o mosehla o mosehla, o boreleli sebopeho ka lehlakoreng le leng, ka lehlakoreng le leng ho na le mongolo o ngotsoeng "MSD 740«.

Zokor Forte e fumaneha ka mokhoa oa matlapa a pinki, a nang le sebopeho se boreleli ka lehlakoreng le leng, ka lehlakoreng le leng ho ngotsoe "MSD 749«.

Leqhubu le na le matlapa a 14, ka lebokoseng ho ka ba le thipa e le 'ngoe kapa tse peli.

Ketso ea pharmacological

Moriana o na le phello e boletsoeng ea hypolipidemic. Letlapa le na le motsoako o sebetsang simvastatin, nakong ea ha hydrolysis e fetoha metsoako e sebetsang. Metabolite ea simvastatin e thibela enzyme HMG-CoA reductase. Enzyme ena e nka karolo ea nako ea pele ea biosynthesis. k'holeseterole.

Ka lebaka leo, tlasa ts'usumetso ea Zokor, boemo ba cholesterol 'meleng bo fokotsehile ka mokhoa o hlakileng, hammoho le litaba tsa cholesterol, tse amanang le lipoprotein tse tlaase le tse tlase haholo. Likahare tsa k'holeseterole ea plasma ea triglycerides le eona ea fokotseha.

Ka nako e ts'oanang, ha u nka simvastatin, boemo ba cholesterol, bo amanang le lipoprotein tse phahameng, bo eketseha haholo.

Ho sebetsa ha sethethefatsi ka mefuta e fapaneng hoa hlokomeleha. Hyperlipidemia, haholo-holo le heterozygous, lelapa, eseng lelapa. Hape, lithethefatsi li sebetsa ka mefuta e tsoakaneng ea hyperlipidemia ketsahalong eo lijo ha ea lekana ho thathamisa li-lipids tsa plasma.

Palo ea lipids ho plasma e fokotseha matsatsi a 14 kamora ho qala kalafo. Tabeng ena, boleng bo phahameng ka ho fetisisa bo bonoa libekeng tse 6 tsa kalafo. Ho feta moo, ha u sebelisa moriana, litholoana tsena lia bolokoa.

Kamora hore kalafo e phethe, butle-butle matšoao a cholesterol e felletseng kahara plasma a khutlela litekanyetsong tsa pele, tse neng li hlokometsoe pele o nka moriana.

Pharmacokinetics le pharmacodynamics

Khokahano e phahameng ka ho fetisisa ea li-metabolites tsa simvastatin maling e bonoa lihora tse 1,3-2.4 kamora hore motho a noe tekanyetso e le 'ngoe ea moriana. Ekaba 85% ea simvastatin e nkiloeng ka molomo e kenella 'meleng.

Kamora puso ea kahare, ha e bapisoa le lisele tse ling, ho bonoa karolo e phahameng ea ntho e sebetsang ka har'a sebete.

Nakong ea karolo ea pele ho pholletsa le mali a sebete, simvastatin e tšeloa metsoako, ka mor'a moo lithethefatsi le li-metabolites li ntšoa 'meleng ka bile.

Ho ja lijo hang hoba u noe moriana ha ho khahlanong le litlhare tsa sethethefatsi. Ka kalafo ea nako e telele, simvastatin ha e bokelle liseleng tsa 'mele.

Matšoao a ho sebelisoa

Ts'ebeliso ea Zokor e bonts'oa batho bao e leng karolo ea sehlopha se nang le kotsi e kholo ea kholo lefu la pelo ho sa tsotelehe lipids tsa mali. Sehlopha sa kotsi se kenyeletsa batho ba nang le maemo a latelang a kopaneng:

cerebrovascular pathologies, ho kenyelletsa stroke(nalane)
lefu la tsoekere(moriana o ka thibela liponahatso tsa khatello ea methapo ea methapo le ho fokotsa tlhokeho ea ho nchafatsa le ho pongoa lipheo tse tlase),
pathology ea phallo ea mali a phallo.

Motsoako ona o sebelisoa kalafo ea batho ba nang le ts'oaetso ea lefu la pelo le bakuli ba nang le hypercholesterolemia. Maemong ana, Zokor e ka thibela ponahatso ea liso tsa methapo ea pelo ka pelong, nts'etsopele ea mathata a mang.

Zokor e boetse e laeloa bakuli ba baholo maemong a joalo:

batho ba maemo a phahameng ka kakaretso k'holeseterole, apolipoprotein Bhammoho le cholesterol, e amanang le lipoprotein tse fokolang tse tsamaeang le lijo,
ka hypertriglyceridemia,
ka k'holeseterole e tlase ea lipoprotein tse phahameng haholo, tse amanang le hypercholesterolemia ea mantlha ha li ntse li ja,
le mofuta o homozygous oa lelapa oa hypercholesterolemia o tsamaellanang le mekhoa e meng ea kalafo le ea ho ja.

Contraindication

Litaba tse mabapi le tšebeliso ea Zokor ke tsena:

ho amoheloa hantle le metabolism ea lactose,
mafu a hlobaetsang a sebete, keketseho e kholo le e tsitsitseng ea palo ea transaminases ea tlhaho e sa tsejoeng,
ho se mamelle motho ka mongb
ho ima le ho fepa ka tlhaho,
lilemo ho fihlela lilemo tse 10.

Litaba tse amanang le tšebeliso ea Zokor ke tsena:

Maemong a joalo, moriana o laetsoe ka hloko.

Tekanyetso le tsamaiso Zokor forte

Pele le nakong ea phekolo, lijo tsa hypocholesterol li lokela ho bonoa. Kahare, tekanyong ea pele ea 10 mg hang, mantsiboea, ka hypercholesterolemia e bonolo kapa e itekanetseng Tekanyetso ea pele ke 5 mg, haeba ho hlokahala, tekanyetso e eketseha butle-butle ka nako ea libeke tse 4. Le malapa a homozygous hypercholesterolemia Tekanyetso ea letsatsi le letsatsi - 40 mg hang, ka mantsiboea kapa 80 mg / letsatsi (ho aroloa ho isa tekanyetso tse 3 - 20 mg hoseng, 20 mg thapama, 40 mg ka shoalane). Ka lefu la pelo tekanyetso ea pele ke 20 mg, hang, mantsiboea, haeba ho hlokahala, butle-butle e eketseha ka linako tse ling tsa libeke tse 4 ho isa ho 80 mg.

Side effect Zokor forte

Hlooho, ho tsekela, ho ruruha, dyspepsia, hepatitis / jaundice, pancreatitis, mesifa cramps, myalgia, myopathy, rhabdomyolysis, paresthesia, peripheral neuropathy, anemia, alopecia, letlalo rash, pruritus, hypersensitivity reaction (uritisaria, hypersensitivityity sensors , khaello ea phefumoloho, malaise ka kakaretso, angioedema, lefu la lupus, ramatiki, ramatiki, arthralgia, ESR, thrombocytopenia, eosinophilia), tlhekefetso ea laboratori e bitsoang alkaline phosphatase, gamma-glutamyltranspeptidase, lesapo la mesifa la leqemeineine phosphokinase, liphetoho litekong tsa ts'ebetso ea sebete ".

Maemong a 'maloa a tsebahalang a overdose (lethal dose e phahameng - 450 mg), ha ho matšoao a itseng kapa litlamorao tse fumanoeng. Phekolo ea matšoao e sebelisoa.

Ka tsela e leka-lekaneng e ka ama phello ea li-anticoagulants tsa coumarin. Ha e kopantsoe le cyclosporine, itraconazole, ketoconazole, metsoako ea fibric acid, niacin, erythromycin ,cacithromycin, li-protease inhibitors, nefazodone, kotsi ea rhabdomyolysis e eketseha. Phekolo e lokela ho khaotsa haeba myopathy e tiisitsoe kapa e belaelloa.

Pele o qala kalafo, ho kgothaletswa ho etsa (ebe o pheta-pheta) ho ithuta ka ts'ebetso ea sebete. Ha boemo ba transaminase bo qala ho feta moeli o tloaelehileng ka makhetlo a 3, moriana o felisitsoe. E laetsoe ka hloko ho bakuli ba sebelisang joala hampe le / kapa ba nang le nalane ea lefu la sebete.

Qoba hole le bana.

Se ke oa sebelisa kamora letsatsi la ho felloa ke nako le bontšitsoeng ka har'a sephutheloana.

U ka nahana ka li-analogu tsa Zokor forte ka mekhahlelo e loketseng, e theko e tlase ebile e theko e phahameng:

Pheko ena ke ea sehlopha "Atherossteosis". Hape sehlopheng sena ho kenyelletsa: Dipromonium, Brilinta, Benzaflavin

Sesebelisoa sena ke sa sehlopha sa "lefu la" cerebrovascular ". Hape sehlopheng sena ho kenyelletsa: Actovegin concentrate, NICOTINIC ACID-VIAL, Kapilar

Litlamorao

Litla-morao tse joalo li ka hlaha nakong ea kalafo ea bakuli ba nang le Zokor:

ho hloka kutloano le bohloko ka mpeng, ho thunya, mathata a ho nyekeloa,
hlooho e bohloko maikutlo a bofokoli bo akaretsang phokolo ea mali,
ho tsekelacramps peripheral neuropathy, paresthesiamemori le likotsi tsa boroko,
lekhopho la letlalo, alopecia, ho hlohlona.

Maemong a sa tloaelehang, a ntshetswa pele myopathy, rhabdomyolysists'ebetsong ea ho nka simvastatin, hammoho le ho fokotseha ha ts'ebetso ea sebete. Litlaleho tsa nts'etsopele ea myalgia li tlalehiloe. Ka kakaretso, Zokor e mamelloa hantle ke bakuli.

Ka hypersensitivity ho lithethefatsi, edema ea Quincke, vasculitis e ka hlaha dermatomyositisthrombocytopenia, eosinophilia, ramatiki, Keketseho ea ESR, arthralgia le ba bang

Litaelo tsa ho sebelisa Zokora (Mokhoa le litekanyetso)

Litaelo tsa ts'ebeliso ea Zokora li fana ka hore mokuli o nooa pilisi ka molomo, ho sa tsotelehe lijo. Tekanyetso ea letsatsi le letsatsi ea moriana e lokela ho nooa mantsiboea, ha ho na lebaka la ho e arola ka tekanyetso e 'maloa.

Tekanyetso e tloaelehileng ea simvastatin ka letsatsi ke 5-80 mg. Ho feta 80 mg ea simvastatin ka letsatsi ha ea lokela ho nkuoa.

Ngaka e khetha tekanyetso, ha ka linako tsohle e ntse e nahanela boemo ba lipids ho plasma. Tekanyetso ha e fetolehe hang kamora libeke tse 'ne.

Molemong oa thibelo le kalafo Lefu la pelo ea Ischemic Khahlano le semelo sa lijo, ho nooa lethalamo la 40 mg la simvastatin kamehla.

Ho hypercholesterolemiahaeba kalafo ea lijo e sa fane ka liphetho tse lakatsehang, ho fanoa ka tekanyetso ea 20 mg ea simvastatin ka letsatsi. Haeba litaba tsa lipidma lipid li hloka ho fokotsoa ka 45% kapa ho feta, tekanyetso ea pele ka letsatsi e kanna ea ba 40 mg.

Haeba mokuli amokhoa o tebileng kapa o bobebe oa hypercholesterolemia, joale tekanyetso ka letsatsi e ka fokotsoa ho 10 mg.

Ngaka e etsa qeto ea tekanyetso e hlokahalang ea moriana, ho lekanya boemo ba lipids le ho netefatsa katleho ea moriana ka mor'a ho qala kalafo. Haeba libeke tse 4 kamora ho qala kalafo, phello e lebelletsoeng ha e bonoe, ketsahalong ena, tekanyetso ea moriana e eketsoa, empa butle-butle ho fihlela ho boletsoe phello e boletsoeng.

Ho homozygous Familia hypercholesterolemia Khahlano le semelo sa ho ja le mekhoa e meng ea kalafo, tekanyetso ea ho qala ea Zokor e lokela ho ba 40 mg ka letsatsi, kapa 80 mg ea simvastatin e beoa le boemo ba hore 20 mg ea moriana o nooa thapama, le 40 mg ka shoalane.

Bacha ba nang le hypercholesterolemia ea homozygous ba peo ea mantlha ba fuoa 10 mg ea moriana ka letsatsi. Tekanyetso e phahameng ka ho fetisisa ea letsatsi le letsatsi ea meriana bakeng sa bacha ke 40 mg.

Tšebelisano

Tšusumetso e ntle e bonoa ka kalafo e tšoanang Zokor le tse latellanang li-acid acid.

Ka tsamaiso e tšoanang ea li-fibrate, cyclosporine le lipid tse fokotsang lipid ka letsatsi, o ka se nke ho feta 10 mg ea moriana. Zokor.

Batho ba amohelang Verapamil le Amiodaroneha ea lokela ho noa ho feta 20 mg ea simvastatin ka letsatsi.

Simvastatin ha e sebetse mesebetsing ea enzymatic ea CYP3 A4.

Ka tsamaiso e le 'ngoe ea lithethefatsi tse thibelang ts'ebetso ea CYP3 A4, monyetla oa ho nts'etsapele myopathy le rhabdomyolysis ho ba nkang simvastatin e eketseha. Hoa hlokahala hore u se ke oa kopanya Zokor le itraconazole, Erythromycin, nefazodone, ketoconazole, telithromycin.

Monyetla oa ho ba le myopathy le rhabdomyolysis oa eketseha ha o ntse o nka amiodarone, diltiazema, gemfibrozil, cyclosporine, niacin, fusidic acid, danazole, verapamil, fibrate.

Tlas'a tšusumetso ea Zokor e ntlafatsa sephetho coumarin anticoagulants.

Ha ho nka litha e le nngwe tsa lero la morara ka letsatsi, ho hlokomeleha keketseho e kholo ea plasma ea simvastatin, e leng ho eketsang monyetla oa rhabdomyolysis.

Ha u nka 20-40 mg ea simvastatin ka letsatsi, phello e khonahala coumarin anticoagulants. Ka lebaka leo, menyetla ea ho tsoa mali e eketseha.

Zokor Forte - sethethefatsi bakeng sa kalafo ea lefu la pelo le coronia

Zokor Forte ke e 'ngoe ea lithethefatsi tse sebetsang ho phekola lefu la pelo le methapo e meng ea pelo.

Moriana ona o hlahisoa ka mokhoa o bonolo oa pompo, mme motheo oa eona ke hypolipedimic ntho simvastatin.

Ts'ebeliso ea moriana ho latela litaelo e fokotsa kotsi ea lefu ho bakuli ba nang le lefu la pelo.

Maemong a mangata, nka matlapa a Zocor Forte hang ka letsatsi ka tekanyo e behiloeng ke ngaka.

Pele o qala mokhoa oa kalafo, ho bohlokoa hore u ithute likarolo tsohle tsa sehlahisoa sena sa lithethefatsi, hape u nahane ka litlamorao le li-contraindication.

Zokor Forte e sebetsana joang le lithethefatsi tse ling?

Pele o qala ho nka matlapa a Zokor Forte, o lokela ho ela hloko likarolo tsa tšebelisano le meriana e meng.

Ka tsamaiso ea eona e ts'oanang ka danazol, verapamil, amiodarone kapa cyclosporine, menyetla ea ho ba le myopathy e eketseha.

Ts'ebeliso e tšoanang ea Zokora Forte le lithethefatsi tse li-acid acid li fana ka phello e ntle ea kalafo.

Hape ho lokela ho hopoloa hore ho na le lithethefatsi tse 'maloa tseo ho nkoang hore li nooa hammoho le matlapa a Zokor Forte. Tsena li kenyeletsa:

erythromycin,
itsraconazole,
ketoconazole,
telithromycin
nefazodone.

Sebopeho sa moemeli ea fokotsang lipid

Ntle le karolo e sebetsang ea simvastatin, matlapa a Zokor ka sebopeho sa ona a na le lintho tse ling. Har'a tsona ke:

lactose le hypromellose,
MCC
ascorbic le citric acid,
starch ea poone
magnesium stearate,
iron oxide (e mosehla le e khubelu).

Pharmacodynamics le pharmacokinetics

Zokor e thibela ho fokotsoa ha HMG-CoA ka metabolites ea eona mme e thibela motsoako oa mevalonate, o fokotsang tlhahiso ea limolek'hule tsa stearols le cholesterol. Hammoho le thepa ea inhibitory, lithethefatsi li kenya li-receptor liseleng tsa sebete tse arabelang lipids tse tlase tsa boima ba molek'hule. Li-receptors tsena li hapa limolek'hule tsa karolo ea LDL 'me li ntlafatsa katse ea tsona.

Mochine oa ts'ebetso ea li-statins

Ho thibeloa ha HMG-CoA reductase ka simvastatin ho lebisa ho phello e joalo ea lithethefatsi ho tloha ho nka statin ena:

index ea k'holeseterole e tlaase,
e theola karolo ea LDL,
ho theola limolek'hule tsa triglycerides le karoloana ea cholesterol ea VLDL,
fokotseha ha apolipoprotein B,
lipid-high-density lipids (HDL) e nyolohela ho - 14,0%,
keketseho ea index ea apoA.

Litlamorao tsa ts'ebeliso ea lithethefatsi ho tsoa ts'ebelisong ea Zokor li ka utloahala kamora libeke tse peli, le boholo bo phahameng - kamora matsatsi a 30- khale a khalendara

Pharmacokinetics Zokor 'meleng oa motho e bonahatsoa ka tsela e latelang:

Khatiso e phahameng ka ho fetisisa ea simvastatin maling e na le halofo ea lihora tse peli ho isa ho tse peli kamora ho tsamaisoa ka molomo. Ho pepeseha ho latela litekanyetso li behiloeng ke ngaka.
ntho e sebetsang e kenelletse 'meleng ha e se ho feta 85% ea litekanyetso li nkuoa ka molomo,
bioavailability ea lithethefatsi - 20%,
sethethefatsi se kenella kahara "placental" nakong ea kemolo,
95% ea lithethefatsi li tlama liprotheine le metsoako ea tsona,
ha ho na pokello ea simvastatin 'meleng, e u lumellang hore u sebelise moriana bakeng sa tšebeliso ea nako e telele,
halofo ea bophelo ba simvastatin e tloha lihora tse 18 ho isa ho tse 20,
Zokor e tlosoa ke 70% ka thuso ea li-acid acid le mala ka mouoane,
10% ea motsoako o ka sehloohong e tšeloa moroto.

Matšoao a ts'ebeliso le a contraindication

Fana ka moemeli ea fokotsang lipid Zokor bakeng sa kalafo ea li-pathologies tse ling. Har'a tsona ke:

hypercholesterolemia ea mantlha ea heterozygous
homozygous genetic hyperlipidemia,
Hypercholesterolemia
dysbetalipoproteinemia ntle le lijo,
hypertriglyceridemia hammoho le lijo.
ho fokotsa tsoelo-pele ea systemic atherosclerosis.

Hape, moriana o fanoa e le thibelo ea bobeli nakong ea kamora lefu le kamora lefu la sethoathoa.

Ts'ebeliso ea statin molemong oa prophylactic e sebetsa hape, e leng bakeng sa:

Thibelo ea myocardial infarction le stroke stroke
fokotsa liketsahalo tsa ho ba le mathata a mangata a mmele le ho shoa ha batho kapele ho lefu lena.
thibela khafetsa le boholo ba litlhaselo tsa nakoana tsa ischemic,
ho emisoa ha tsoelo-pele ea systemic atherosulinosis,
ho theola sekhahla sa cholesterol ea LDL, le ho eketsa karoloana ea HDL maling a mali.

Contraindication ho li-statins

Statins ha e ea fuoa maemo a joalo le litsietsi 'meleng oa mokuli:

mamello ho likarolo le lactose,
keketseho ea li-transaminases liseleng tsa sebete,
lefu la sebete sethaleng se matla sa nts'etsopele ea pathology,
mefuta e fapaneng ya hepatitis le cirrhosis,
myopathy ea mesifa
nalane ea lefu la mesifa ho mokuli
nakong ea bokhachane le pelehi,
bana ba ka tlase ho lilemo tse 10.

Basali ba lilemong tsa ho beleha ba behiloe li-statin feela ka ts'ireletso e ntle ea ho thibela pelehi. Haeba mosali a fumanoa a imme nakong ea kalafo, moriana o felisoa hang-hang, hobane simvastatin e feta sethaleng sa placental mme e ka ama sebopeho sa lisebelisoa tsa masapo le mesifa ka popelong, hammoho le sesosa sa nts'etsopele ea methapo ea methapo ea lisele.

Bana ba ka tlase ho lilemo tse 10 ha ba fuoe moriana ka lebaka la kotsi e kholo ea ho ba le myopathy le rhabdomyolysis ea lisele tsa mesifa.

Thupelo ea ts'ebeliso

Zokor e nkuoa hang ka letsatsi. Sena se etsoa hantle pele u robala. Letlapa leo le ke ke la hlafuna, empa le lokela ho metsoa ka botlalo, 'me le hlatsoe ka metsi a lekaneng.

Pele a qala kalafo ea statin, mokuli o lokela ho ja lijo tsa cholesterol bakeng sa likhoeli tse 1-2. Lijo li lokela ho tsamaea le lithuto tsohle tsa bongaka tsa Zokor.

Ngaka e khetha litekanyetso ka mokhoa o ikhethileng bakeng sa mokuli ka mong, ho latela litšobotsi tsa 'mele, mofuta oa pathology le boemo ba tsoelo-pele ea hae, mme e ka ba ho tloha ho 5 mg ho isa ho 80 mg ka letsatsi. O ka eketsa litekanyetso tsa letsatsi le letsatsi tsa moriana ho feta pele ho libeke tse 4 tsa ho nka litafole. Ho feta 80.0 mg ea karolo e thehiloeng ea simvastatin ka letsatsi ha e ngoletsoe bakuli.

Qala thuto ea lithethefatsi ka 5 mg, 10 kapa 20 mg. Khetla ea pele e ipapisitse le ts'ebetso ea methapo le matšoao a boemo ba lipid:

Phekolo ea hypercholesterolemia e lokela ho qala ka tekanyetso ea 10 mg. Nakong ea kalafo, o ka eketsa litekanyetso (butle-butle), ho ea lethal dose le lumelloang ka bongata ka letsatsi - li-milligram tse 80.
Bakeng sa thibelo ea lefu la pelo le coronary kapa dyslipidemia, lethalamo la 40 mg le ka khethoa.
Bakeng sa kalafo ea "homozygous" genetic hypercholesterolemia, ngaka e fana ka tekanyetso ea 40 mg. Haeba ho se na phello ea lithethefatsi, joale kamora khoeli ea kalafo, ho thehiloe lethal dose ea 80 mg. Tekanyetso e arotsoe ka tekanyetso ea hoseng ea 40 mg le tekanyetso ea mantsiboea ka tekanyetso e le 'ngoe.
Bakuli ba tsofetseng ha ba hloke ho fetola litekanyetso tsa matlapa. Ha ho na tlhokahalo ea phetoho ea tekanyetso bakeng sa li-pathologies tsa renal tse nyane.
Bana ba tsoang ho lilemo tse 10 ba nang le liphatsa tsa lefutso hypercholesterolemia ea mofuta o homozygous, ngaka e fana ka tekanyetso ea 10 mg ka letsatsi. Bakeng sa bana ba ka tlase ho lilemo tse 18, tekanyetso bakeng sa thupelo ea kalafo e ka eketsoa ho li-milligram tse 40 ka letsatsi. Tekanyetso ea 80 mg mg bongoaneng ha e khethoe.

Litla-morao tse ka bang teng le litla-morao tse ngata

Lipalo tsa matsatsing a pele li mamelletsoe hantle ke 'mele, hangata litla-morao li ka hlaha nakong ea kalafo ka sethethefatsi se nang le litekanyetso tsa 40 mg, kapa ha u sebelisa moriana o nang le lethal dose le leholo ka letsatsi - t 80 mg.

Ha ho na karolo e fetang 10% ea bakuli ba nang le karabelo e joalo ea 'mele ha ba sebelisa moriana:

nts'etsopele ea phokolo ea mali,
tahlehelo ea moriri
letlalo le letlalo,
chizzi, migraine,
dyspepsia
jaundice ea etiology ea lijo,
myalgia le myopathy,
cramps
pancreatitis e hlobaetsang
limb paresthesia,
neuropathy ea mafapha a potoloho,
rhabdomyolysis,
urticaria le ho hlohlona.

Matšoao a sa tloaelehang ke:

ho hema hanyane
Ho ruruha ha litho tsa litho tsa ka hare,
arthralgia,
mokhathala
thrombocytopenia
keketseho ho ESR,
ho hloka mamello ho banna.

Matšoao feela a ka bang karabelo e joalo ea mmele,

keketseho ea enzyme ea phosphokinase,
keketseho ea indexine ea phosphokinase,
keketseho e matla ea index ea transaminase liseleng tsa sebete.

Haeba ho na le lithethefatsi tse ngata tse feteletseng, kalafo e nang le matšoao le ho hlaka ho tsoang ka mpeng e sebelisoa. Ts'ebetso ea hemodialysis ha e na thuso.

Bakuli bohle ba lokela ho tsebisoa ka monyetla oa ho nts'etsapele li-pathologies tsa mesifa pele ba nka. U lokela ho ela hloko likarolo tse joalo:

ka matla afe kapa afe a bohloko ba mesifa kapa masapo, mokuli o hloka ho bona ngaka. Khafetsa, ho nka Zokor ho baka bofokoli ba mesifa,
nakong ea phekolo e nang le litafole ka tekanyetso ea 20 mg kapa 40 mg ea motsoako o sebetsang, ho lula ho hlokahala hore ho hlahlojoe tšebetso ea moetso oa phosphokinase maling, hammoho le mosebetsi oa liphio.

Keketseho ea indexine ea creatine phosphokinase ke sesupo sa ho thehoa ha myopathy tsamaisong ea mesifa. Phekolo e tlameha ho emisoa kapa lethal dose e fetoloe ka tekanyo e amohelehang.

Tlhahlobo ea lingaka le bakuli

Litlhahlobo mabapi le Zokora li ntle haholo. Ka bobeli bakuli le lingaka li hlokomela hore na lithethefatsi li sebetsa hantle hakae.

Zokor e sebetsang le hypolipidemic e sebetsa molemong oa mathata afe kapa afe a lipid metabolism 'meleng. Ntle le moo, e sebelisoa e le prophylaxis bakeng sa methapo e matla ea methapo ea methapo ea pelo le pelo, hammoho le sethaleng sa ho hlaphoheloa kamora ho hlaseloa ke stroke le ho otloa ke pelo, hammoho le sethaleng sa ho fola.

Litaelo tse khethehileng

Joalo ka lithethefatsi tse ling - li-inhibitors tsa GM-CoA reductase, Zokor e ka tsosa nts'etsopele myopathies. Ka linako tse ling e iponahatsa ka sebopeho rhabdomyolysis, eo maemong a mang e tsamaeang le ho hloleha ho matla ha a amanang le renal.

Qoba ts'ebelisano 'moho ea Zokor le lithethefatsi, tseo, ha li nkuoa ka nako e le ngoe, li ka tsosang ponahalo ea myopathy.

Bakuli bohle ba behiloeng Zocor ba lokela ho lemosoa ka monyetla oa ponahatso. myopathiesmme tlhoko, kamora nts'etsopele ea matšoao a pele a lefu lena, hang-hang etela ngaka. Ha u belaella la pele la nts'etsopele ea myopathy, kalafo e lokela ho emisoa.

Ho bakuli ba bang ba fumaneng Zokor, ho ile ha hlokomeloa keketseho ea li-enzyme tsa sebete. Kamora ho emisoa kalafo, butle-butle matšoao a ile a khutlela boemong ba pele.

Pele o qala thupelo ea bongaka, ho bohlokoa ho etsa tlhahlobo ea ts'ebetso ea sebete. Boithuto bona bo tlameha ho phetoa pele ho eketsa tekanyetso ea simvastatin ho fihlela letsatsi le letsatsi.

Ka ho se leka-lekane ha methapo e itseng, mokuli ha a hloke ho fokotsa tekanyetso ea moriana. Ka ho se sebetse hantle haholo ha renal, lethal e ka holimo ho 10 mg le ka hlahisoa feela kamora tumello ea ngaka e eang.

Lipehelo le maemo a polokelo

Bophelo ba sefuba ba moriana ona ho tloha nakong ea tlhahiso ea bona ke lilemo tse peli.

Matlapa a lokela ho bolokoa ka har'a sephutheloana sa mantlha ka mocheso o sa feteng 25-30⁰, sebakeng se lefifi le se ommeng se sa fumaneheng ho bana.

Lithethefatsi Zokor Forte ke lengolo feela.

Theko ea eona e mahareng li-pharmacy tsa Russia e nka li-ruble tse 450-500 (bakeng sa sephutheloana se nang le matlapa a 14) le li-ruble tse 700-750 (bakeng sa matlapa a 28)

Maphodisa Ukraine fana ka ho reka moriana ona ka theko ea li-hryvnia tse 150 ho isa ho tse 500, ho latela palo ea matlapa a pakileng.

Lifeme tsa sejoale-joale li fana ka li-analogu tse 'maloa tse sebetsang hantle tsa Zokora Forte, tse nang le ntho e tšoanang e sebetsang' me li na le phello ea hypolipedic.

Ha u khetha mothusi ea itseng, ho ka ba molemo hore u ee ngakeng.

Li-analog tse tummeng ka ho fetisisa tsa matlapa a Zocor Forte ke:

Setlhare sa Zokor Forte se tšoaneloa ke litlhahlobo tse ngata tse ntle bakeng sa aterese ea sona ka lebaka la tšebeliso e bonolo ea ts'ebeliso le phello e phahameng ea kalafo.

Boholo ba bakuli ba e sebelisitseng bakeng sa prophylactic le kalafo, ba hlokometse ho fokotseha ho hoholo ha cholesterol, hammoho le phello e ntle ka kakaretso ho boemo ba tsamaiso ea methapo ea pelo.

Qetellong ea sengoloa sena, o ka fumana litlhahlobo tse qaqileng tse lebisitsoeng ho moriana ona. Haeba u na le boiphihlelo ba hau ba ho sebelisa matlapa a Zokor Forte, etsa bonnete ba hore u arolelana maikutlo a hau le baeti ba bang sebakeng sena.

Seo u lokelang ho nahana ka sona pele u nka matlapa a Zocor Forte?

Setlhare sa Zokor Forte, se hlahisitsoeng ka mokhoa oa matlapa, se etselitsoe phekolo le thibelo ea lefu la pelo le coronary.
Tekanyetso e kholo ea letsatsi le letsatsi e lekaneng ke 80 mg.
Ha hoa lumelloa ho nka meriana nakong ea kemaro le ho lactation, mafu a matla a sebete, hammoho le maemong a ho se mamellane ho motho ka mong likarolo.
Nakong ea kalafo, lino tse tahang li tlameha ho qheleloa ka thoko lijong.
Nako ea kalafo e boletsoeng ke ngaka ha ea lokela ho fetisoa.

Litaelo le tšebeliso ea Zokor: analogues, litekolo, sebopeho, theko

Lekarstva.Guru> Z> Litaelo le lisebelisoa Zokor: analogues, litekanyetso, sebopeho, theko

Zokor forte ke lithethefatsi tse thibelang nts'etsopele ea maloetse a methapo ea pelo le pelo. Ha e nyenyefatse boemo ba cholesterol e mpe feela maling a mokuli, empa e boetse e beha boemo ba cholesterol ka botlalo. Ka lebaka la thepa ea eona ea boloi, Zokor e fokotsa lefu la bakuli ka 30%! 'Me ho bakuli ba lefu la tsoekere, menyetla ea mathata a coronary e fokotsehile ka 55%!

Zokor - ke eng?
Fomu ea tokollo
Matšoao a ho sebelisoa
Contraindication
Litaelo tsa tšebeliso, litekanyetso
Litlamorao

Zokor - ke eng?

Zokor ke lithethefatsi tse theolelang tlase tse fumanehang ka bongata. E fumanoa ka belisoa ho Aspergillus terreus. Ntho e sebetsang ea lithethefatsi Zokor forte - simvastatin.

Ena ke lactone e sa sebetseng, e kenang ts'ebetsong ea hydrolysis, e theha li-hydroxy-acid tse tsamaellanang. Ka lehlakoreng le leng, ke metabolite e thibelang HMG-CoA.

HMG-CoA ke reductase, kapa enzyme e nang le bokhoni ba ho ferekanya lebelo la mantlha le le thibelang mehato ea cholesterol biosynthesis 'meleng oa motho.

HMG-CoA, e fetoha mevalonate, ke mohato oa mantlha oa cholesterol biosynthesis. Ka hona, ts'ebeliso ea Zokor forte ha e bake lits'ebetso tse kopaneng tsa li-sterols tse chefo 'meleng.

Sena se netefatsoa ke lithuto tse entsoeng UK bakeng sa lilemo tse 5 le likhoeli tse 5.

Ntle le tsena tsohle tse kaholimo, HMG-CoA e ka fetoloa hore e be Co-A, enzyme e kenyang letsoho lenaneong le leholo la mekhoa ea biosynthesis.

Re lokela ho hlokomela hore lithuto tse ngata le tsona li tiisa - lithethefatsi Zokor e sebetsa hantle ho bakuli bohle. Ho sebetsa hantle ha hoa itšetleha ka lilemo, bong, boemo ba cholesterol kapa ho ba sieo / ho ba teng ha kalafo e tšoanang.

Haeba u belaela kalafo eo u nang le eona, maikutlo a marang-rang a ka u thusa ho lekola likarolo tsohle tse ntle le tse mpe tsa kalafo e joalo.

Litaelo tsa tšebeliso, litekanyetso

Ho latela litaelo, pele a qala tšebeliso ea lithethefatsi Zokor forte, mokuli o lokela ho fuoa taelo hypocholesterol ja lijo. Hoa hlokahala ho latela phepo e joalo nakong eohle ea kalafo.

Tekanyetso e khothalelitsoeng e bontšitsoeng litaelong e tsoa ho 5 mg ho isa ho 8 mg. Hoa hlokahala ho sebelisa moriana mantsiboea, hang ka letsatsi. Nakong ea ho khetha tekanyetso e nepahetseng ea moriana, nako e lokela ho bonoa: ho hlokahala hore u fetole palo ea Zocor e sa feteng nako e le 'ngoe ho libeke tse 4. Palo e lekaneng ea Zokor forte ka letsatsi ke 80 mg.

Ho shebiloe haholo ke phetoho ea litekanyetso ho bakuli ba nang le IHD kapa kotsi ea ho ba le IHD. Tekanyetso e kholo e lumelloang ka letsatsi, ho bakuli ba joalo e tlase haholo - 40 mg. Nka lithethefatsi makhetlo a 1 ka letsatsi, ka shoalane.

Ho latela litaelo sethethefatsi se lokela ho kopanngoa ka mokhoa o ikhethileng oa ho ja le ho ikoetlisa bakeng sa bakuli:

Ka lefu la pelo la ischemic kapa kotsi ea ho ba le lefu la pelo,
Lefu la tsoekere
Nalane ea lefu la qoqotho ea pelo
ho ba le lefu la methapo ea pelo.

Bakuli ba nang le hypercholesterolemia ba sa kenyellelitsoeng lethathamong le kaholimo ba fuoa mori o fapaneng ka ho felletseng. Motsoako oa mantlha tabeng ena ke 20 mg. Nka meriana hang ka letsatsi, mantsiboea.

Bakeng sa bao kalafo ea bona e kenyang phokotso e kholo litekanyetsong tsa LDL, lethal dose la pele le eketsoa ho 40 mg. Haeba mokuli a e-na le hypercholesterolemia e bonolo, palo ea sethethefatsi ke 10 mg.

Khetho ea tekanyetso e lokela ho etsoa ho latela litaelo, ka nako e boletsoeng ea phetoho ea tekanyetso.

Homositic Familyal hypercholesterolemia e fana ka mefuta e mmedi ya kamohelo. Pele: moriana o nooa ka nako e le 'ngoe ka letsatsi, mantsiboea, ka bongata ba 40 mg. Ea bobeli: 80 mg ea moriana o arotsoe ka litekanyetso tse tharo:

Nyeoe ena ea tšebeliso e sebelisoa haeba kalafo e 'ngoe, e kenyelletsang phokotso e kholo ea cholesterol, e sa sebetse ntlheng ena. Kapa Zokor e sebelisoa joalo ka kalafo ea adjunctive.

Haeba mokuli a nka li-fibrate, tekanyo e loketseng e fetoloa ka mokhoa o fapaneng ho tsoa ho bakuli, ho latela hore na ke li-fibrate life tse boletsoeng.

Kaha ho se sebetse hantle ha renal ke tlolo e tebileng ea kalafo le Zokor forte, hangata ba leka ho e khutlisa ka li-analogues.

Empa haeba khetho ena e sa amohelehe, ho bohlokoa ho fana ka mathata ohle a ka khonehang mme o tsebe hore maemong a mokuli, ho bohlokoa hore u sebelise Zokor forte.

Leha ho le joalo, haeba mokuli a e-na le bothata bo fokolang ba a renal, litekanyetso tse tloaelehileng tsa moriana ha li lokisoe. Ho tloha leha e le hanyane, empa pheko e etsoa khafetsa ke liphio.

Litlamorao

Ho latela liphuputso, kotsi ea litlamorao kamora ho sebelisa Zokor forte ke 2% feela. Ka lebaka lena, kalafo e nang le matlapa a Zokor e loketse ho tšoana le li-analogues. Ntle le moo, leano la theko la sehlahisoa ha le fetisoe. Theko e tloaelehileng ea lithethefatsi Ukraine e tsoa 15 ho isa ho 30 UAH. Theko e tloaelehileng Russia e tsoa ho li-ruble tse 400 ho isa ho tse 700.

Pele ho ts'ebeliso ea lithethefatsi ka mokhoa oa bongaka, 1% e ne e le linyeoe litlamorao tse joalojoalo ka:

Litlamorao tse lingtse amanang le ts'ebeliso ea lithethefatsi li hlaha ka 0.5-0.9% ea linyeoe:

Ho na le bopaki ba linyeoe tse sa tloaelehang tsa myopathy.

Ponahalo ea matšoao a joalo e ea etsahala:

Ho tsekela
Nausea
Hepatitis
Letšollo
Pancreatitis
Ho phomola
Jaundice
Peripheral neuropathy,
Rhabdomyolysis,
Myalgia
Dermatomyositis
Ho hlohlona
Letlalo la letlalo
Mokokotlo oa mesifa
Bofokoli bo akaretsang
Boloetse

Lithuto tsa laboratori le ka lilemo tse ngata tsa boikoetliso ha li so ka tsa senola litlamorao tsa ts'ebeliso e feteletseng ea bakuli. Tekanyetso e lekantsoeng ea moriana ke 3.6 g. Maemong a overdose, mokuli o fuoa kalafo e tloaelehileng le kalafo ea matšoao.

Pele o qala kalafo, ho a hlokahala hore o thuto e phethahetseng ea ts'ebetso ea liphio. Boithuto bo joalo bo tlameha ho phetoa pele ho keketseho e 'ngoe le e' ngoe ea moriana.

Bakeng sa bakuli ba noang sethethefatsi sena, ho ile ha hlokomeleha liphetoho maemong a enzyme ea hepatic. Leha ho le joalo, kamora ho qeta thupelo, matšoao butle-butle a khutlela ho tloaelehileng.

Haeba mokuli a e-na le mofuta o mongata oa ho se sebetse hantle ha renal, ho eketseha hoa tloaelo ea mantlha (10 mg) ho etsoa feela kamora ho buisana le tumello ea setsebi.

Tlhaloso ea lithethefatsi Zocor

Ke ne ke tšaba ho lumela kalafo, empa ngaka e ile ea tsitlallela, ea re 'na, kalafo e' ngoe e ke ke ea sebetsa. Ka lehlohonolo, ba ile ba nkholisa hore ke se ke le haufi.

Milena, Kharkov

Ke ne ke e-na le bothata bo fokolang ba ho ruruha le cholesterol e phahameng. Ke ile ka lumela ho amohela kalafo Zokor. Ka nako e telele ho ile ha khethoa lethalamo le amohelehang, empa tsena ke litla-morao, taba ea mantlha ke hore lefu lena le morao. Ke ile ka lumela.

Alexander, Minsk

Ka 'nete, ha ke na bongaka haholo, ka hona ngaka e boletse - ho bolela hore re tlameha ho lumela. Ntho ea bohlokoa ke ho fumana setsebi se loketseng seo u se lumelang, joale kalafo efe kapa efe e tla atleha. Ka kakaretso, boiphihlelo ba ka bo botle.

Svetlana Oryol

Zokor: litaelo tsa tšebeliso, theko, litekolo le li-analogues

Zokor e sebelisang moriana oa hypolipidemic e sebelisetsoa ho theola index ea cholesterol ea mali ho hypercholesterolemia. Zokor ke inhibitor ea HMG-CoA reductase hape ke karolo ea sehlopha sa meriana ea li-statins. Sehloohong sena re tla hlahloba litaelo tsa ts'ebeliso ea lithethefatsi Zokor, matšoao le li-contraindication, analogues le litekolo.

Mefuta ea pharmacological

Moetsi o hlahisa moriana ka sebopeho sa letlapa. Matlapa a nang le litekanyetso tsa 10 mg ea motsoako o sebetsang o na le 'mala o pinki o bobebe, sebopeho se boreleli ka lehlakoreng le leng,' me ho taka ho teng ka lehlakoreng le leng.

Matlapa a Zokor a na le litekanyetso tsa 20 mg simvastatin li na le 'mala o mosehla o sootho, sebopeho se boreleli ka lehlakoreng le leng,' me ho taka ho na le lehlakoreng le leng.

Litafole tse nang le litekanyetso tsa simvastatin 40 mg (Zokor Forte) li na le 'mala o pinki, sebopeho se boreleli lehlakoreng le leng,' me ho taka ho na le lehlakoreng le leng.

E pakiloe matlapeng ka lithupa tsa likotoana tse 14. Mekhabiso e 'ngoe le e' ngoe ea karete e ka ba le lithutsoana tse 1 kapa tse peli.

Sena se netefatsoa ke litaelo tsa tšebeliso. Li-Analogs tsa Zokor li tla nkuoa ka tlase.

Matšoao a ho sebelisoa

Moriana o khothalletsoa hore o sebelisoe ke bakuli ba sehlopha sa kotsi bakeng sa nts'etsopele ea pelo le ischemia. Hape kotsing e kenyelletsa batho ba nang le li-pathologies tse kang:

Mathata a potoloho ea potoloho.
Lefu la tsoekere.
Cerebrovascular pathology.

Setlhare se ka sebelisoa ho phekola bakuli ba nang le lefu la pelo la ischemic, hypercholesterolemia. Tabeng ena, e thusa ho thibela li-pathologies tsa pelo le methapo ea mali.

Lethathamo la matšoao a ts'ebeliso ea lithethefatsi "Zokor" le tsoteha.

E kanna ea khothalletsoa hore e sebelisoe maemong a latelang:

Homozygous mofuta oa lelapa oa hypercholesterolemia (hammoho le kalafo ea ho ja, mekhoa e meng).
K'holeseterole e fokolang ea lipoprotein tse phahameng haholo tse amanang le hypercholesterolemia ea mantlha e bakoang ke pheko ea lijo.
Hypertriglyceridemia.
Maemo a phahamisitsoeng a apolipoprotein B, cholesterol e felletseng (hammoho le kalafo ea ho ja).

Tšusumetso e mpe

Ho latela litaelo tsa tšebeliso le litlhahlobo ho "Zokor", matšoao a latelang a mabe a ka hlaha ho mokuli nakong ea kalafo:

Arthralgia, ESR e eketsehileng, ramatiki, eosinophilia, thrombocytopenia, dermatomyositis, vasculitis, angioedema.
Mosebetsi oa sebete o fokotsehileng, rhabdomyolysis, myopathy.
Ho hlohlona, alopecia, lekhopho.
Ho senya boroko, ho hopola, ho pepa, ho ruruha ha methapo ea kutlo, ho tsitsipana, ho tsekela.
Boloetse, bofokoli bo akaretsang, hlooho e bohloko.
Ho holofala, ho ruruha, bohloko ba ka mpeng, ho hlonama ka mpeng.

Ka kakaretso, sethethefatsi se lumelloa hantle ke bakuli.

Tšebeliso ea meriana

Nka sethethefatsi "Zokor" ka molomo, ntle le ho bua ka lijo. Tekanyetso e tloaelehileng ea letsatsi le letsatsi ea lithethefatsi ke 5-80 mg. 80 mg - litekanyetso tse kholo tse lumelloang tsa simvastatin, tse ka noang motšehare.

Tekanyetso e khethoa ke setsebi ka bonngoe. Kahoo, molemong oa kalafo le thibelo ea mafu a pelo a kopaneng le kalafo ea lijo, ho bontšoa ho nka 40 mg ea Zokora ka letsatsi.

Bakeng sa ho phekola hypercholesterolemia, ho bontšoa ho nka 20 mg ea Zokor ka letsatsi.

Tšusumetso ho sebete

Lithuto tsa kliniki ho bakuli ba baholo ba fumanang simvastatin li fumane keketseho e tsitsitseng maemong a li-enzyme tsa sebete. Ka ho felisoa kapa tšitiso ea moriana, hangata ts'ebetso ea lipapatso li khutlela boleng ba tsona ba pele. Sena ha se amane le lefu la sethoathoa kapa matšoao a mang a kliniki, empa ho ka supa ho kheloha ho latela sephetho sa liteko tse sebetsang tsa sebete le / kapa tšebeliso e mpe ea joala pele ho qala kalafo. Liphetoho tsa Hypersensitivity ha lia ka tsa fumanoa.

Pakete ea matlapa a 28 a Zokora ka litekanyetso tsa 20 mg e tla bitsa li-ruble tse 750, ka litekanyetso tsa 40 mg - 500 ruble. Ho latela sebaka le marang-rang a litlama.

Li-analog tsa Zokora

Haeba ho hlokahala, Zokor e ka nkeloa sebaka ke e 'ngoe ea litokisetso tse latelang: Simvor, Zovatin, Simgal, Vabadin, Levomir, Aterostat, Simlo, Simvakard, Avestatin, Simvastatin, Akorta, Pravastatin, Simvastol, Ariescor, Simgal, Lovastatin, Lipitor, Liptonorm, Rosulip, Rosart, Tevastor, Atomax , Liprimar, Atoris, Rosucard, Vasilip, Roxer, Rosuvastatin, Tulip, Krestor.

Tšusumetso ea meriana ena e ts'oana, tlhoko ea ho sebelisa moriana o itseng mohlaleng ka mong o lokela ho khethoa ke ngaka.

"Krestor" ke e 'ngoe ea liemahale tsa "Zokor". Motsoako o sebetsang ho motsoako oa eona ke calcium rosuvastatin. Lintho tse ling ke: magnesium stearate, glycerol triacetate, E172, E171, hypromellose, calcium phosphate, lactose monohydrate, crospovidone, cellcose ea microcrystalline.

Moqapi "Crestor" o fumaneha ka foromo ea letlapa. Letlapa le leng le le leng le ka ba le 5, 10, 20, 40 mg ea lintho tse sebetsang. Joaloka Zokor, Krestor ke setlhare se fokotsang lipid.

Ho leng betere - "Zokor" kapa "Crestor" ho thata ho e rarolla.

Matšoao a ka sehloohong a ts'ebeliso ea ona ke:

Thibelo ea nts'etsopele ea methapo ea pelo le pelo.
Atherosclerosis
Hypercholesterolemia e tsoakiloeng (e le karolo ea kalafo e rarahaneng hammoho le ho theola boima ba 'mele, ho ikoetlisa ka' mele, kalafo ea lijo).
Thibelo, kalafo ea hypercholesterolemia ea lelapa.

"Crestor" e kopantsoe le boteng ba maemo a joalo a 'mele le a bophelo:

Ho qhekella karolo efe kapa efe ea lithethefatsi.
Lilemo ho isa ho lilemo tse 18.
Myopathy
Pheko ka lithethefatsi tsa cyclosporin.
Boimana, nako ea ho beleha.
Mefuta e matla ea hepatic pathologies, haholoholo, e amanang le keketseho ea palo ea liprotheine maling.

Khahlano le semelo sa tšebeliso ea lithethefatsi, matšoao a fosahetseng a kang:

Tubular proteinuria.
Asthenia.
Letšollo, ho sokela, pancreatitis, ho nyekeloa le pelo.
Likarabo.
Myopathy
Polyneuropathy, hlooho e bohloko.

Nka "Crestor" e lokela ho ba ka molomo, ka botlalo, ho qoba ho hlafuna. Ho khothalletsoa ho qala kalafo ea lithethefatsi ka litekanyetso tsa pele tsa 5 mg, kamora libeke tse tharo ngaka e nka tlhoko ea ho eketsa litekanyetso ho 20 kapa 40 mg ho latela bophelo bo botle ba mokuli.

Hangata bakuli ba ipotsa hore na ho na le lithethefatsi life, Zokor kapa Krestor. Karabo ea potso ena e kanna ea fapana. Pele, motsoako o sebetsang o ipapisitse le metsoako e fapaneng e sebetsang. Taba ea bobeli, 'mele oa motho ka mong ke sethethefatsi: sethethefatsi se sebetsang ho mokuli a le mong se kanna sa se tšoanele mokuli e mong. Ke ka lebaka leo setsebi se lokelang ho khetha meriana e loketseng ka ho fetisisa.

Simvastatin

"Simvastatin" ke analogue ea "Zokor" mabapi le karolo e sebetsang, e thehiloe ho simvastatin. Ha ho sebelisoa lintho tse thusang: butylhydroxyanisole, macrogol, talc, hypromellose, ascorbic acid, starch ea poone, lactose, povidone, citric acid, titanium dioxide, calcium stearate.

Moetsi "Simvastatin" o fumaneha ka mokhoa oa matlapa, a pakiloeng ka marang-rang kapa makotikoti a polasetiki ea polymer mme a na le litekanyetso tsa ntho e sebetsang 10, 20, 40, 80 mg.

Har'a matšoao a ts'ebeliso ea Simvastatin ke maemo a latelang:

Thibelo ea tsoelo-pele ea atherosulinosis.
Thibelo ea tlhaselo ea nakoana ea ischemic, stroke.
Thibelo ea infraction ea myocardial.
Mofuta o kopaneng oa hypercholesterolemia, hypertriglyceridemia (haeba ts'ebetso e lekaneng ea 'mele le kalafo ea lijo e sa sebetse).
Hypercholesterolemia ea mantlha (haeba ho se na katleho ho tsoa ho mekhoa eo e seng ea lithethefatsi le kalafo ea ho ja) ho bakuli ba kotsing ea ho ba le atherosclerosis.

"Simvastatin" e netefalitsoe ka botlalo hore e sebelisoe haeba mokuli a e-na le maemo a joalo a bophelo le 'mele:

Lilemo ho isa ho lilemo tse 18.
Lefu la sethoathoa sa sebete.
Tšusumetso ea motho ka mong ho likarolo tsa moriana.
Eketseha AST, ALT.
Myopathy, methapo e meng ea mesifa ea marapo.

Har'a li-contraindication tse amanang (maemo a hlokang tšebeliso ea lithethefatsi ka hloko):

Mehato ea ho buoa, likotsi.
Lefu la ho akheha
Mathata a methapo.
Matšoao a ts'ebetso ea endocrine system.
Ho se leka-lekane ke electrolyte ea metsi.
Hypotension ea Arterial.
Bokhoba ba tahi
Nako ea ntlafatso kamora ho fetisoa ha litho, kalafo ea immunosuppression.

Tšebeliso ea "Simvastatin" e ka ama boemo ba mokuli hampe, ea baka matšoao a fosahetseng a kang:

Ho ruruha, ho hlonama ka bongateng, mefuta e bolaeang ea ho se sebetse hantle ha methapo, ho halefisoa ke rhabdomyolysis, ho fokotseha ha potency.
Alopecia, pruritus, dermatomyositis.
Myalgia, rhabdomyolysis, bofokoli bo matla, myopathy, mesifa ea mesifa.
Ho phefumoloha, ho ruruha ha letlalo, ho fufuleloa ha letlalo, ho eketsa ESR, feberu, urticaria, photosensitivity, lupus-syndrome, eosinophilia, polymyalgia rheumatica, thrombocytopenia, angioedema.
Peripheral neuropathy.
Ho hloka boroko, ho ts'oaroa ke mesifa, ho sitisoa ha tatso, ho tsekela, ho ruruha, masapo a astheniki, migraine, pono e lerootho.
Ho nyekeloa ke pelo, lefu la lets'ollo, ho hlatsa, AST, ALT, CPK, ho qhekella, bohloko ba epigastric, flatulence, pancreatitis.

Ts'ebeliso ea "Simvastatin" e lokela ho qalisoa ka tekanyetso e fokolang, butle-butle e li eketsa khoeli le khoeli. Ho khothalletsoa ho sebelisa lithethefatsi hang ka letsatsi, ka nako ea ho robala, ho nka letlapa le le leng. Litekanyetso li beoa ke ngaka ho latela boemo ba mokuli. E le molao, katleho ea moriana o bonoa ha u sebelisa 20 mg ea moriana ka letsatsi.

Litsenyehelo tse tloaelehileng tsa sephutheloana sa Simvastatin ke li-ruble tse 400.

Simgal hape ke analogue ea Zokor ho ea ka karolo e sebetsang. E na le simvastatin. Likarolo tse ling ke: lactose monohydrate, microcellulose, magnesium stearate, citric acid monohydrate, starch ea pregelatinized, butyl hydroxyanisole, ascorbic acid.

Moqapi "Simgal" o fumaneha ka sebopeho sa litafole, matlapa a ka ba le litekanyetso tsa simvastatin 10, 20, 40 mg.

Matšoao a ka sehloohong a ts'ebeliso ea Simgal:

Thibelo ea li-pathologies tsa CCC ho bakuli ba nang le lefu la tsoekere, lefu la atherosclerosis.
Therapy ea hypercholesterolemia (ea mantlha, lefutso la lefutso).
Pheko ea dyslipidemia e tsoakiloeng.

Simgal e netefalitsoe maemong a latelang:

Phekolo ea meriana e nang le lithethefatsi tse thibelang cytochrome CYP3A4 (Nefazodon, Telithromycin, Itraconazole, Nelfinar, Clarithromycin, Erythromycin).
Nako ea kemaro, moimana.
Methati e phahameng ea transaminase.
Ho eketseha ha hepatic pathologies.
Ho eketseha habonolo ha likarolo tsa moriana.

Khahlano le semelo sa ts'ebeliso ea "Simgal", matšoao a latelang a mabe a ka hlaha:

Ho eketsa litekanyo tsa alkaline phosphatase, li-transaminases.
Bofokoli, bokhutšoanyane ba ho hema, eosinophilia, photosensitivity, thrombocytopenia, polymyalgia ea mofuta oa rheumatic, ramatiki, vasculitis, angioedema.
Asthenia, myositis, mesifa ea mesifa, myopathy.
Alopecia, ho hlohlona, rash, jaundice, hepatitis.
Pancreatitis, bohloko ba ka mpeng, ho hlatsa, setuloana se khopisang.
Peripheral polyneuropathy, ho tsitsipana, kizungu, paresthesia, hlooho e opang, khaello ea mali.
Ho se sebetse hantle ka thobalano, khatello ea maikutlo, ho sitisoa kelellong, ho robala.

Ho khothalletsoa ho nka Simgal hang ka letsatsi bakeng sa 10-20 mg. Maemong a mang, tumellanong le setsebi, keketseho ea tekanyetso ea letsatsi le letsatsi ho ea ho 80 mg e lumelloa. Haeba ho hlokahala, Letlapa le ka aroloa likarolo tse 'maloa. Tekanyetso e nepahetseng ea moriana e lokela ho khethoa ke ngaka ea hau.

Maikutlo a bakuli ka Zokor

Phekolo ena le li-analogues tsa eona li khetholloa ke bakuli e le mokhoa o sebetsang oa ho thibela li-pathologies tsa CVS le kalafo ea hypercholesterolemia. Ho leka-lekana ha tšebeliso ea lithethefatsi ho bonoa ka thoko, hangata lingaka li khothaletsa tekanyetso e le 'ngoe ka letsatsi ea moriana, e nolofalletsang ts'ebeliso ea mokuli ea lithethefatsi.

Re ile ra lekola litaelo tsa ho li sebelisa le Zokor, litekolo, hammoho le analogues ho eona.

Tekanyetso le tsamaiso

Pele le nakong ea phekolo, lijo tsa hypocholesterol li lokela ho bonoa. Kahare, tekanyong ea pele ea 10 mg hang, ka mantsiboea, ka tekanyo e fokolang kapa e leka-lekaneng ea hypercholesterolemia, tekanyetso ea pele ke 5 mg, haeba ho hlokahala, tekanyo e ntse e eketseha butle-butle ka nako ea libeke tse 4. Ka hypercholesterolemia ea lelapa, lethal dose ea letsatsi le letsatsi ke 40 mg hang, ka mantsiboea kapa 80 mg / letsatsi (e arotsoe ka litekanyetso tse 3 - 20 mg hoseng, 20 mg thapama, 40 mg ka shoalane. Ka lefu la pelo ea coronary, lethal dose la pele ke 20 mg, hang, ka mantsiboea, haeba ho hlokahala, butle-butle e eketseha ka linako tse ling tsa libeke tse 4 ho isa ho 80 mg.

Litlhokahalo tsa polokeho

Bophelo ba Shelf ea lithethefatsi Zokor®

Letlapa le koahetsoeng ka filimi ea 10 mg - lilemo tse 3.

lifilimi tse koahetsoeng ka filimi 20 mg - 3 lilemo.

matlapa a koahetsoeng 10 mg - 3 lilemo.

matlapa a koahetsoeng 20 mg - 3 lilemo.

matlapa a koahetsoeng 40 mg - lilemo tse 2.

matlapa a koahetsoeng 80 mg - 2 lilemo.

Se ke oa sebelisa kamora letsatsi la ho felloa ke nako le bontšitsoeng ka har'a sephutheloana.

Litaelo tsa ho sebelisa Zokora: mokhoa le litekanyetso

Pele a qala ts'ebeliso ea Zokor, mokuli o fuoa lijo tse tloaelehileng tsa hypocholesterol, tse lokelang ho bonoa nakong eohle ea kalafo.

Tekanyetso ea letsatsi le letsatsi ea lithethefatsi (ho tloha ho 5 ho isa ho 80 mg) e lokela ho nooa tekong e le 'ngoe ka shoalane.

Nakong ea nako ea ho kenyelletsa lethal dose, keketseho ea eona e etsoa bonyane makhetlo a 4 a beke. Sekhahla se phahameng se lumelletsoeng letsatsi ka leng ke 80 mg.

Bakuli ba nang le lefu la methapo ea mokokotlo kapa kotsi e kholo ea kholo ea bona: 40 mg hang ka letsatsi. Phekolo ea lithethefatsi e qala ka nako e ts'oanang le kalafo ea ho ja le ho ikoetlisa.
Bakuli ba nang le hypercholesterolemia (eseng ba kotsing ea ho ba le lefu la pelo): lethal dose la pele - 20 mg ka letsatsi. Maemong a mang (haeba ho fokotseha hoa LDL ka ho feta ho 45%), ho ka fanoa ka tekanyo ea pele ea 40 mg. Ka mofuta o fokolang o leka-lekaneng oa hypercholesterolemia, kalafo e ka qala ka lethal dose ea letsatsi le letsatsi ea 10 mg, haeba ho hlokahala, butle-butle e eketsa,
Bakuli ba nang le homozygous Famation hypercholesterolemia: 40 mg hang ka letsatsi kapa 80 mg ho litekanyetso tse 3 tse arohaneng - 20 mg hoseng le thapama le 40 mg ka shoalane.Tabeng ena, Zokor e ka fuoa sehlahisoa se le seng kapa ho kenyelletsa mokhoa o mong oa phekolo o theolang cholesterol (mohlala, LDL plasmapheresis).

Zokor e sebelisoa e le monotherapy kapa e kopantsoe le li-sequence tsa bile tsa acid. Maemong ana, phetoho ea tekanyo e hlokahala ho latela lithethefatsi tse sebelisoang ka nako e le ngoe:

Danazole, cyclosporine, gemfibrozil, li-fibrate tse ling (ntle le fenofibrate), lipid-lowing niacin (> 1000 mg / day): tekanyetso ea letsatsi le letsatsi ea Zokor ke 10 mg,
Verapamil, amiodarone: tekanyetso ea letsatsi le letsatsi ha ea lokela ho feta 20 mg.

Bakuli ba nang le bothata ba ho leka-lekanya ba aefisi ha ba hloke ho fetola tekanyetso. Bakuli ba nang le bothata bo matla ba ho hlaba ba pelo (tumello ea creatinine e ka tlase ho 30 ml / motsotso) ha ba khothaletsoe ho feta tekanyetso ea letsatsi le letsatsi ea 10 mg. Haeba tlhokahalo e joalo e loketse, kalafo e lokela ho etsoa ka tlasa tlhokomelo ea bongaka e hlokolosi.

Li-analog tsa Zokor

Litšoantšiso tsa moriana ona ke meriana Simvastatin, Avestatin, Simvakard, Simlo, Atherostat, Levomir, Vabadin, Simgal, Zovatin, Simvor.

Li fana ka phello e ts'oanang, empa ke setsebi feela se lokelang ho khetha sethethefatsi se nepahetseng ho fetisisa maemong ohle.

Ha ho na tlhaiso-leseling e lekaneng mabapi le tšebeliso ea lithethefatsi tsena baneng, ka hona, sethethefatsi sena ha se sebelisetsoe ho alafa bana ba ka tlase ho lilemo tse 10.

Zokor e sebelisoa ho phekola mofuta oa heterozygous oa hypercholesterolemia ho bacha lilemong tsa ho ja. Tlas'a tšusumetso ea lithethefatsi, boemo ba triglycerides, cholesterol, apolipoprotein B boa fokotseha.

Phekolo ea banana ba nang le lithethefatsi e etsoa ha feela ho ilela khoeli ho ngoanana ea lilemong tsa bocha ho qalile bonyane selemo se fetileng.

Bongata

Maemong a 'maloa a tsebahalang a overdose (lethal dose e phahameng - 450 mg), ha ho matšoao a itseng kapa litlamorao tse fumanoeng. Phekolo ea matšoao e sebelisoa.

Litlhokahalo tsa polokeho

Maemo a polokelo ea lithethefatsi Zokor®

Ka mocheso o sa feteng 30 ° C.

Qoba hole le bana.

Bophelo ba Shelf ea lithethefatsi Zokor®

Letlapa le koahetsoeng ka filimi ea 10 mg - lilemo tse 3.

lifilimi tse koahetsoeng ka filimi 20 mg - 3 lilemo.

matlapa a koahetsoeng 10 mg - 3 lilemo.

matlapa a koahetsoeng 20 mg - 3 lilemo.

matlapa a koahetsoeng 40 mg - lilemo tse 2.

matlapa a koahetsoeng 80 mg - 2 lilemo.

Se ke oa sebelisa kamora letsatsi la ho felloa ke nako le bontšitsoeng ka har'a sephutheloana.

Sokolla foromo le sebopeho

E fumaneha ka mokhoa oa matlapa a koahetsoeng: oval, boreleli ka lehlakoreng le leng - ka lehlakoreng le leng - ho ngotsoe "MSD 735" (matlapa a mmala o mopinki o bobebe) kapa ho ngoloa "MSD 740" (matlapa a mmala o moputsoa o sootho) (14 li-pcs. lithutsoana, malepa a le 1 kapa a mabeli ka har'a lebokose la likarete.

Ntho e sebetsang ke simvastatin:

Letlapa le le leng la 'mala o pinki o bobebe - 10 mg,
Letlapa le le leng la 1 - 20 mg.

Baeti: ascorbic acid, butylhydroxyanisole, cellcosestalline cellulose, lactose monohydrate, stgel ea pregelatinized, citric acid, magnesium stearate.

Sebopeho sa Shell: hydroxypropyl cellulose, talc, methylhydroxypropyl cellulose, titanium dioxide, dyes ironideide e tshehla le iron oxide e khubelu.

Ketso ea pharmacological

Ho latela litaelo, Zokor e tšoauoa ka phello e boletsoeng e fokotsang lipid. Sebopeho sa matlapa a kenyelletsa ntho e sebetsang ea simvastatin, eo, ha hydrolyzed, e fetohelang metsoako e sebetsang. Metabolite ea eona e thibela enzyme HMG-CoA reductase, e amehang ho biosynthesis ea pele ea cholesterol.

Ka lebaka leo, tšebeliso ea lithethefatsi e thusa ho fokotsa bongata ba cholesterol 'meleng, le boemo ba cholesterol e amanang le lipoprotein tse tlaase le tse tlase haholo. Khathatso ea cholesterol ho plasma ea triglycerides le eona e fokotsehile.

Ka nako e ts'oanang, ha u nka Zokor, litaba tsa k'holeseterole e amanang le lipoprotein tse phahameng haholo li eketseha haholo. Setlhare se sebelisoa bakeng sa mefuta e fapaneng ea hyperlipidemia, ho kenyelletsa bao e seng ba lelapa, lelapa, heterozygous. E boetse e laeloa mefuta e kopaneng ea hyperlipidemia maemong ao ha u sebelisa lijo ho ke ke ha khoneha ho nolofatsa khatello ea lipids ka plasma.

Maemo a lipidma lipid a fokotseha matsatsi a 14 kamora ho qala kalafo. Palo ea bona e fihla bonyane bekeng ea 4 - ea 6 ea kalafo. Ka ts'ebetso e eketsehileng ea lithethefatsi, sephetho sena sea bolokoa.

Kamora ho qeta kalafo, matšoao a k'holeseterole e phethahetseng ho plasma butle-butle a khutlela ho a pele, a neng a ikemiselitsoe pele ho lithethefatsi.

Pharmacodynamics le pharmacokinetics

Palo e phahameng ea li-metabolites tsa simvastatin maling e tlalehiloe lihora tse 1,3-2,4 kamora ho nka tekanyetso e le 'ngoe ea Zocor. Hoo e ka bang 85% ea ntho e sebetsang e fumanehang matlapeng e kenella 'meleng ha e nooa ka molomo.

Ha e phekoloa ka sethethefatsi, tekanyo e phahameng ea simvastatin e bonoa sebeteng ha e bapisoa le lisele tse ling. Ka lebaka la "ntlha ea pele" ea ntho ka har'a sebete, e tšeloa matla, ka mor'a moo moriana ka boeona le li-metabolites li ntšoa 'meleng ka bile.

Ho amoheloa ha Zokor ha hoa itšetleha ka tšebeliso ea lijo, e sa amang li-pharmacokinetics tsa lithethefatsi. Pheko ea nako e telele ha e lebise ho bokelleng ha simvastatin liseleng tsa 'mele.

Matšoao a ho sebelisoa

Zocor e fuoa bakuli ba nang le lefu la pelo (CHD) kapa lefu la bokamoso ba lefu lena, hammoho le bakuli ba nang le kotsi e kholo ea ho ba le lefu la pelo (ho kenyeletsa le boteng ba hyperlipidemia), ka mohlala, bakuli ba nang le lefu la tsoekere, bakuli ba nang le lefu la methapo ea methapo, kapa stroke kapa mafu a mang a amanang le lefu la pelo. ho anamnesis. Morero oa lithethefatsi:

Fokotsa kotsi ea lefu ka lebaka la lefu la pelo,
Ho fokotsa menyetla ea ho ba le mathata a tebileng a methapo ea pelo kapa masapo, a kang ho otloa ke lefu le sa foleng la myocardial, lefu la coronary,
Fokotsa kotsi ea ho kena sepetlele bakeng sa litlhaselo tsa angina,
Ho fokotsa menyetla ea ho kenella ka lebaka la ho buuoa ka lebaka la tlhoko ea ho khutlisetsa phallo ea mali a phallo kapa mefuta e meng ea revascularization eo e seng ea coronary.

Hape, ho lihlopha tse thathamisitsoeng tsa bakuli, moriana o fanoa haeba ho hlokahala ho etsa ts'ebetso ea revascularization.

Ntle le moo, Zokor e laetsoe hypercholesterolemia - e le tlatsetso ea lijo maemong ao phepo e nepahetseng le mekhoa e meng ea kalafo e seng lithethefatsi e sa lekanang. Morero oa lithethefatsi:

Phekolo ea mofuta oa hyperlipidemia ho latela sehlopha sa Fredrickson (hypertriglyceridemia),
Therapy ea mofuta oa mantlha oa hyperlipidemia ho latela sehlopha sa Fredrickson (dysbetalipoproteinemia),
K'holeseterole e phahameng e theohileng, cholesterol e tlaase-tlaase-e nang le matla a fokolang haholo, apolipoprotein B le triglycerides,
K'holeseterole e ntseng e eketseha ea li-density lipoprotein (HDL) e ngata ho bakuli ba nang le hypercholesterolemia ea mantlha, ho kenyelletsa le mofuta IIa hyperlipidemia ho latela sehlopha
Fokotsa karolelano ea cholesterol e felletseng ho cholesterol ea HDL, hammoho le cholesterol ea LDL ho cholesterol ea HDL,
Fokotsa maemo a phahameng a cholesterol e felletseng, LDL cholesterol le apolipoprotein B ho bakuli ba nang le homozygous Famal hypercholesterolemia (ho kenyelletsa lijo le kalafo tse ling).

Ho bakuli ba nang le lefu la tsoekere, "Zokor e fokotsa menyetla ea mathata a phello ea methapo ea methapo (ho kenyelletsa le monyetla oa ho ruruha ha trophic ulcers, revascularization le ho pongoa lipelong tse tlase).

Bakeng sa bakuli ba nang le lefu la pelo, le tsamaeang le cholesterol e phahameng, lithethefatsi li ka fokotsa kotsi ea ho ba le lefu la ho ruruha lifuba ponahalo ea mathata le likotsi tse ncha.

Contraindication

Keketseho e sa khaotseng ea maemo a hepatic transaminase maling a mali a sa tsebeng letho,
Lefu le sebetsang la sebete,
Boimana le nako eo e reriloeng ka eona.
Lebone
Hypersensitivity ea motho ka mong ho likarolo tsa moriana.

Ka lebaka la khaello ea ya data ea polokeho tšebeliso ea simvastatin ho bana, ha ho kgothaletswe ho fana ka lithethefatsi ho bana.

Nalane ea rhabdomyolysis,
Lefu la tsoekere
Keketseho e tsitsitseng ea boemo ba transumases ea serum (haeba e feta tloaelo e kaholimo ka makhetlo a 3, moriana o felisitsoe),
Ho se sebetse hantle ha renal (tumello ea tumello ea tumello e ka tlase ho 30 ml / min),
Tšebeliso e mpe ea tahi.

Litaelo tsa ho sebelisa Zokora: mokhoa le litekanyetso

Pele a qala ts'ebeliso ea Zokor, mokuli o fuoa lijo tse tloaelehileng tsa hypocholesterol, tse lokelang ho bonoa nakong eohle ea kalafo.

Tekanyetso ea letsatsi le letsatsi ea lithethefatsi (ho tloha ho 5 ho isa ho 80 mg) e lokela ho nooa tekong e le 'ngoe ka shoalane.

Nakong ea nako ea ho kenyelletsa lethal dose, keketseho ea eona e etsoa bonyane makhetlo a 4 a beke. Sekhahla se phahameng se lumelletsoeng letsatsi ka leng ke 80 mg.

Bakuli ba nang le lefu la methapo ea mokokotlo kapa kotsi e kholo ea kholo ea bona: 40 mg hang ka letsatsi. Phekolo ea lithethefatsi e qala ka nako e ts'oanang le kalafo ea ho ja le ho ikoetlisa.
Bakuli ba nang le hypercholesterolemia (eseng ba kotsing ea ho ba le lefu la pelo): lethal dose la pele - 20 mg ka letsatsi. Maemong a mang (haeba ho fokotseha hoa LDL ka ho feta ho 45%), ho ka fanoa ka tekanyo ea pele ea 40 mg. Ka mofuta o fokolang o leka-lekaneng oa hypercholesterolemia, kalafo e ka qala ka lethal dose ea letsatsi le letsatsi ea 10 mg, haeba ho hlokahala, butle-butle e eketsa,
Bakuli ba nang le homozygous Famation hypercholesterolemia: 40 mg hang ka letsatsi kapa 80 mg ho litekanyetso tse 3 tse arohaneng - 20 mg hoseng le thapama le 40 mg ka shoalane. Tabeng ena, Zokor e ka fuoa sehlahisoa se le seng kapa ho kenyelletsa mokhoa o mong oa phekolo o theolang cholesterol (mohlala, LDL plasmapheresis).

Zokor e sebelisoa e le monotherapy kapa e kopantsoe le li-sequence tsa bile tsa acid. Maemong ana, phetoho ea tekanyo e hlokahala ho latela lithethefatsi tse sebelisoang ka nako e le ngoe:

Danazole, cyclosporine, gemfibrozil, li-fibrate tse ling (ntle le fenofibrate), lipid-lowing niacin (> 1000 mg / day): tekanyetso ea letsatsi le letsatsi ea Zokor ke 10 mg,
Verapamil, amiodarone: tekanyetso ea letsatsi le letsatsi ha ea lokela ho feta 20 mg.

Litlamorao

Sistimi ea tšilo ea lijo: dyspepsia (lets'ollo, ho nyekeloa le pelo le ho hlatsa), seoelo - pancreatitis, jaundice, hepatitis,
Sistimi ea methapo e bohareng: vertigo, peripheral neuropathy,
Sistimi ea musculoskeletal: myalgia, ka seoelo rhabdomyolysis,
Liphetoho tse ka bakoang ke ho kula le ho hlaseloa ke lefutso: lupus-like syndrome, angioedema, rheumatism ea polymyalgia, ho eketseha ha ESR, eosinophilia, ramatiki, thrombocytopenia, arthralgia, vasculitis, urticaria, hyperemia ea letlalo, photosensitivity, ho hema hanyane, mala ka kakaretso
Boitšoaro ba letlalo: Rash letlalo, ho hlohlona, dermatomyositis, alopecia,
Tse ling: mesifa ea mesifa, paresthesia, malaise ka kakaretso, anemia,
Matšoao a laboratori: litekanyetso tse eketsehang tsa li-transaminase, alkaline phosphatase le gamma-glutamyl transpeptidase, creatine phosphokinase.

Bongata

Haeba ho na le lithethefatsi tse ngata, ho sebelisoa mekhoa ea meriana ea setso ho hlola litlamorao tsa ho tahoa hoa mmele.

Ho sebelisana le lithethefatsi

Lithethefatsi tse latelang tse sebelisitsoeng ka nako e le 'ngoe le simvastatin (haholo litekanyetso tse phahameng) eketsa kotsi ea myopathy / rhabdomyolysis:

Li-inhibitors tse matla tsa CYP3A4: clarithromycin, erythromycin, telithromycin, ketoconazole, nefazodone, itraconazole, human immunodeficiency virusase proteinase inhibitors,
Lithethefatsi tse ling tse fokotsang lipid tse seng li-inhibitors tse matla tsa CYP3A4, empa li ka baka nts'etsopele ea myopathy: gemfibrozil le li-fibrate tse ling (ntle le fenofibrate), niacin (nicotinic acid) ho litekanyetso tsa lipid-lowing (> 1 g / letsatsi),
Cyclosporin, danazole,
Amiodarone, verapamil,
Diltiazem.

Simvastatin, e sebelisoang ka tekanyetso ea letsatsi le letsatsi ea 20-40 mg, e hlahisa phello ea li-anticoagulants tsa coumarin mme e eketsa menyetla ea ho tsoa mali: nako ea prothrombin (Rateo ea Machabeng) e eketseha ho tloha boemong ba pele ba 1.7 ho isa ho 1,8 ho baithaopi ba phetseng hantle, le ho bakuli ba nang le hypercholesterolemia - ho tloha ho 2 , 6 ho isa ho 3,4. Ho kenyelletsa liphetoho tse bohlokoa letšoao lena, bakuli ba fumanang li-coumarin anticoagulants, nako ea prothrombin e lokela ho khethoa pele e qala ts'ebeliso ea Zokor le nako le nako nakong ea phekolo ea pele. Kamora hore pontšo ea INR e tsitse, boikemisetso ba eona bo tsoetseng pele bo tlameha ho etsoa nako le nako bo khothalletsoang ho lekola bakuli ba nang le kalafo ea anticoagulant.

Jusi ea morara e na le bonyane karolo e le 'ngoe e thibelang CYP3A4 mme e ka eketsa litekanyetso tsa plasma tsa lithethefatsi tse entsoeng ka enzyme ena. Tšebeliso ea linoelo tse 1 tsa lero (250 ml) ka letsatsi ha e na bohlokoa ba bongaka. Leha ho le joalo, ha o sebelisa lero le leholo la metsi (ho feta litara e le 'ngoe ka letsatsi) nakong ea phekolo ka simvastatin, boemo ba ts'ebetso ea li-inhibitors tsa HMG-CoA li eketseha haholo. Ka lebaka lena, lino tse ngata tsa lero la morara ha lia lokela ho jeoa nakong ea kalafo.

Li-Analogs tsa Zokor ke: Simvastatin, Simvastatin Zentiva, Avestatin, Simvakard, Simlo, Aterostat, Levomir, Vabadin, Simgal, Zovatin, Simvor.

Nakong ea bokhachane le pelehi

Ts'ebeliso ea moriana ona e patiloe nakong ea nako ea boimana le ho fepa ngoana lebese la matsoele. Ha u nka simvastatin nakong ea kemolo, ho ka hlokomeleha ho nyemeloa nakong ea bokhachane.

Nakong ea kotopo, haeba ho hlokahala, kenya kopo Zokor, o hloka ho emisa ho fepa.

Litlhahlobo mabapi le Zokora

Litlhahlobo tse ngata li tsejoa ka Zokora, ho tiisa ts'ebetso ea lithethefatsi. Motsoako oa eona o sebetsang o hlile o thusa ho fokotsa cholesterol e ngata. Leha ho le joalo, ho fumana sephetho se lebelletsoeng, ho khothalletsoa ho sebelisa lithethefatsi bakeng sa nako e behiloeng ke ngaka e eang. Bakuli ba tlaleha litholoana tse ntle ha ba sebelisa simvastatin e le mokhoa oa ho thibela pelehi.

Sebopeho, foromo ea tokollo

Zokor e lokolloa ka mokhoa oa matlapa a koahetsoeng. Ke 'mala o oval, perekisi (10 mg) kapa tan (20 mg) ka' mala.

Letlapa le le leng la Zocor le na le 10 kapa 20 mg ea simvastatin. Ts'ebetso e thusang e etsoa ke: ascorbic acid, citric acid, butylhydroxyanisole E320, selulose, starch, magnesium stearate, tsoekere ea lebese. Khetla ea khalase e na le cellulose e fetotsoeng, hypromellose, titanium dioxide (E 171), talc, mosehla, oxide e khubelu ea tšepe (E172, E171).

Zokor: matšoao a sebelisoa

Ho ea ka litaelo, Zokor e fuoe bakuli ba nang le mofuta oa lefutso kapa mofuta o fumanoeng oa hypercholesterolemia e le tlatsetso ea lijo, ha o le mong o sa lekana:

fokotseha ka bongata ba OH, X-LDL, TG, apolipoprotein B,
keketseho ea HDL-C ho bakuli ba nang le mofuta oa IIa / IIb hyperlipidemia,
fokotsa tekanyo ea X-LDL / X-HDL, OH / X-HDL,
triglycerides e tlase.

Ho boetse ho bontšoa matlapa a Zokor bakeng sa batho ba kotsing e kholo ea ho ba le lefu la pelo: le lefu la tsoekere, stroke kapa mafu a mang a amanang le lefu la pelo. Ho hlophisa metabolism ea cholesterol, hammoho le metabolite e meng ea mafura, e thusa ho thibela nts'etsopele ea mathata.

Mokhoa oa ts'ebeliso, litekanyetso

Phekolo ea Zokor e fanoa feela kamora tsela ea kalafo ea ho ja e etselitsoeng ho fokotsa maemo a cholesterol. Ho sebetsa hantle ha matlapa ho latela taeo ea mokuli. Haeba a sa khomarele lijong, o tla fokotsoa ka zero.

Tekanyetso ea letsatsi le letsatsi ea Zokor ke 5-80 mg. Matlapa a nooa hang / ka letsatsi, ka shoalane, ka metsi a mangata. Lijo ha li ame ho amoheloa ha moriana. Ka hona, ha ho na tlhoko ea ho hokahanya ho nka Zokor ka lijo.

Ho khethoa ha moriana ho qala ka tekanyetso e fokolang, e ka hlahlojoang kamora matsatsi a 28.

Bakuli ba nang le lefu la pelo la ischemic / kotsi e kholo ea kholo ea lona, moriana o laetsoe lethal dose la 40 mg / ka letsatsi. Bakeng sa bakuli ba bang ba nang le hypercholesterolemia, hangata litekanyetso li qala ka 20 mg / ka letsatsi.

Ka lefu la tlhaho la lefu la cholesterol metabolism, Zokor o laetsoe tekanyetso ea 40 mg / letsatsi (hang) kapa 80 mg / letsatsi (makhetlo a mararo: 20 mg hoseng, thapama, 30 ka shoalane).

Monyetla oa ho beha matlapa a bana bakeng sa bana ba lilemo tse 10 ho isa ho tse 17 le hyperlipidemia ea lelapa o na le lipelaelo. Phuputsong, sehlopha se le seng sa bana se nkile Zokor libeke tse 48, le placebo ea bobeli. Ho ne ho sena phapang e ikhethang ea mamello. Empa bakeng sa liqeto tse sa utloahaleng, hoa hlokahala ho etsa liteko tsa nako e telele le ho lekola litlamorao tsa lithethefatsi ho nts'etsopele ea kelello le thobalano.

1. Litaelo tsa ho sebelisoa

Ho nka Zokor ho lokela ho tsamaisana le lijo tse reretsoeng ho theola cholesterol. Bakuli ba laetsoe ho tloha ho 5 ho isa ho 80 mg ea moriana bakeng sa tšebeliso ea letsatsi le letsatsi pele o robala. Ha ho khonehe ho feta tekanyetso e phahameng. Tekanyo e nepahetseng e khethoa ka bonngoe, phetoho e ngoe le e ngoe ho Zocor e khothalletsoang ha e sa feteng hang ka khoeli.

Phekolo e lokela ho ba telele, ha sethethefatsi se tlosoa, mokuli o khutlela boemong ba hae ba pele.

Tekanyetso ea lithethefatsi bakeng sa mafu a fapaneng hangata e ka tsela e latelang:

Lefu la pelo ea Ischemic, lefu la tsoekere, lefu la sethoathoa - 40 mg letsatsi le letsatsi, ka nako e ts'oanang, o lokela ho latela mokhoa oa ho ja le ho etsa thuto ea pelo-mmele,
Hypercholesterolemia - e nang le mofuta o fokolang oa bokuli, 10- mg mg e beoa mantsiboea a mang le a mang haeba ho hlokahala ho theola maemo a LDL ka ho feta 45 %-40 mg,
Hypercholesterolemia ea lelapa - ho khothalletsoa ho qala kalafo ka 40 mg ea moriana mantsiboea kapa 80 mg makhetlo a mararo ka letsatsi (20 + 20 + 40 ka nako e le ngoe).

Haeba Zokor e laetsoe hammoho le Danazol, Cyclosporin, Gemfibrozil le li-fibrate tse ling kapa Niacin, tekanyo e phahameng ea letsatsi le letsatsi ha ea lokela ho feta 10 mg.

Hammoho le Verapamil kapa Amiodarone, boleng bona ke 20 mg. Bakuli ba nang le ho se sebetse hantle haholo ha renal ba khothalletsoa ho fokotsa sekhahla sa letsatsi ho isa ho 10 mg.

3. Lisebelisoa tse sebetsang

Zokor e laeloa bakuli ba nang le lefu la pelo la ischemic kapa sepheo sa lefu lena, hypercholesterolemia ka mefuta e fapaneng, le lefu la tsoekere.

Lithethefatsi li na le thepa e latelang:

loana le matšoao a lefu la pelo la ischemic,
e fokotsa kotsi ea lefu ka lebaka la lefu la pelo,
e thibela nts'etsopele ea mathata a tebileng a methapo ea pelo (methapo, ho nyekeloa ke pelo, jj),
e fokotsa tlhokeho ea ts'ebetso e ntlafatsang ea methapo ea kutlo le mefuta e meng ea phallo ea mali,
e fokolisa litlhaselo tsa angina,
cholesterol e tlase, LDL le B-lipoprotein,
e eketsa HDL (cholesterol e thusang),
e laola maemo a triglyceride.

Ho tsoekere ea lefu la tsoekere, Zokor e thibela ponahalo ea likotsi likepeng tsa pherekano, 'me haeba ho ka ba le lefu la methapo ea methapo le hypercholesterolemia hammoho e lieha nts'etsopele ea coronary atherossteosis le mathata a mang.