Litaelo tsa Diabinax (Diabinax) bakeng sa tšebeliso

Matlapa a tšoeu, a pota-potile, a sephara, a manehiloe ka thipa 'me a na le mola o le mong ka lehlakoreng le leng.

PRING microcrystalline cellulose, starch, povidone, sodium methylparaben, colloidal silicon dioxide (Aerosil), magnesium stearate, sodium starch glycolate, talc, metsi a hloekisitsoeng.

Li-pcs tse 10 - Mabokose (1) - liphutheloana tsa karete.
20 likhomphutha. - Mabokose (1) - liphutheloana tsa karete.

Matlapa a tšoeu, a pota-potile, a sephara, a manehiloe ka thipa 'me a na le mola o le mong ka lehlakoreng le leng.

PRING microcrystalline cellulose, starch, povidone, sodium methylparaben, colloidal silicon dioxide (Aerosil), magnesium stearate, sodium starch glycolate, talc, metsi a hloekisitsoeng.

Li-pcs tse 10 - Mabokose (1) - liphutheloana tsa karete.
20 likhomphutha. - Mabokose (1) - liphutheloana tsa karete.

Matlapa a tšoeu, a pota-potile, a sephara, a manehiloe ka thipa 'me a na le mola o le mong ka lehlakoreng le leng.

PRING microcrystalline cellulose, starch, povidone, sodium methylparaben, colloidal silicon dioxide (Aerosil), magnesium stearate, sodium starch glycolate, talc, metsi a hloekisitsoeng.

Li-pcs tse 10 - Mabokose (1) - liphutheloana tsa karete.
20 likhomphutha. - Mabokose (1) - liphutheloana tsa karete.
Li-pcs tse 10 - lithutsoana (6) - lipakete tsa karete.

Ketso ea pharmacological

Diabinax ke lithethefatsi tsa hypoglycemic tse tsoang molokong oa II oa sulfonylurea II. E hlohlelletsa secretion ea insulin ke manyeme, e hlahisa phello ea sekhahla sa "insulin", e phahamisa kutloisiso ea lisele tsa pherekano ho insulin. E susumetsa ts'ebetso ea li-enzymes tse kenang ka hare - mesifa ea glycogen synthetase. Fokotsa nako ea nako ho tloha motsotso oa ho ja ho isa ho qala ho secretion ea insulin. E khutlisa tlhoro ea pele ea insulin secretion (ho fapana le tse ling tse tsoang ho sulfonylurea, ka mohlala, glibenclamide le chlorpropamide, e amang haholo nakong ea karolo ea bobeli ea secretion). Fokotsa tlhoro ea hyperglycemia kamora ho ja.

Ntle le ho ama metabolism ea carbohydrate, e ama le microcirculation. Fokotsa tlhoro ea hyperglycemia kamora ho ja. E fokotsa khokahano ea liplatelete le khokahano, e liehisa nts'etsopele ea "thrombus" ea lebota. E boetse e lekanya boteng ba methapo, e thibela nts'etsopele ea microthrombosis, e khutlisetsa ts'ebetso ea 'mele ea parietal fibrinolysis.

E fokotsa kutloisiso ea methapo ho adrenaline. E na le thepa ea anti-atherogenic, e theola khatello ea cholesterol e felletseng maling.

E fokotsa tsoelo-pele ea lefu la tsoekere le lefu la tsoekere sethaleng se sa feteng. Ka lefu la tsoekere le lefu la tsoekere le tšebeliso ea nako e telele, ho na le phokotseho e kholo ea proteinuria.

Ha e lebise keketseho ea boima ba 'mele, hobane e na le tšusumetso e kholo tlhorong ea pele ea insulin secretion mme ha e bake hyperinsulinemia, e thusa ho fokotsa boima ba 'mele ho bakuli ba batenya, ka mor'a lijo tse nepahetseng.

Mofumahali

Ha a nooa ka molomo, moriana o ananeloa hantle ho tsoa ho tšilo ea lijo. C max ho plasma ea mali e fihlella lihora tse ka bang 4 ka mor'a ho nka tekanyetso e le 'ngoe ea 80 mg. Plasma e tlamang protein ke 94%. E tšelisoa ka har'a sebete ho hlaha metsoako e mengata ea metabolites. E epolloa ke liphio - 70% ka sebopeho sa metabolites, e ka tlase ho 1% e ts'oaroa e sa fetoloe ka har'a moroto, ka makhopho - 12% ka sebopeho sa metabolites. T 1/2 - lihora tse ka bang 12

Melemo ea lithethefatsi DIABINAX

Tekanyo ea lithethefatsi e beoa ka bonngoe, ho latela lilemo tsa mokuli, lipontšo tsa kliniki ea lefu lena le boemo ba ho itima lijo ha glycemia le lihora tse peli ka mor'a ho ja. Tekanyetso ea pele ea letsatsi le letsatsi ke 80 mg, karolelano ea letsatsi le letsatsi ke 160 mg, mme lethal dose le leholo la letsatsi le letsatsi ke 320 mg. Diabinax e nooa ka molomo makhetlo a 2 / ka letsatsi (hoseng le mantsiboea) metsotso e 30-60 pele ho lijo.

Ho sebelisana le lithethefatsi

Sulfanilamides, salicylates, anticoagulants e sa tsejoeng, li-anabolic steroid, beta-blockers, fibrate, chloramphenicol, phenfluramine, fluoxetine, guanethidine, li-inhibitors tsa MAO, pentoxifylline, theophylline, caffeine, phenylbutazone, le tetracycline gline le tetracycline.

Ka tšebeliso e tšoanang ea gliclazide le acarbose, ho eketsoa phello e matla ea hypoglycemic, e hlokang tokiso ea litekanyetso tsa meriana ena.

Cimetidine e eketsa khatello ea "gliclazide" plasma ea mali, e ka bakang hypoglycemia (khatello ea methapo ea methapo, letsoalo le sa sebetseng), ka hona, tšebeliso ea meriana ena ha e khothalletsoe.

Li-Barbiturates, chlorpromazine, glucocorticosteroids, sympathomimetics, glucagon, nicotinic acid, estrogens, progestin, lithibela-pelehi tsa molomo, diuretics, rifampicin, lihomone tsa qoqotho, letsoai la lithium le fokolisa phello ea hypoglycemic ea glyclazide.

Tšebeliso e tšoanang ea gliclazide le imidazole derivatives (ho kenyelletsa miconazole) e hanoa.

Kholisa foromo, lipakete le sebopeho sa Diabinax

Matlapa a tšoeu, a pota-potile, a sephara, a manehiloe ka thipa 'me a na le mola o le mong ka lehlakoreng le leng.

Bahlomphehi: cellcose ea microcrystalline, starch, povidone, sodium methylparaben, colloidal silicon dioxide (aerosil), magnesium stearate, sodium starch glycolate, talc, metsi a hloekisitsoeng.

20 likhomphutha. - Mabokose (2) - lipakete tsa karete.
20 likhomphutha. - lithutsoana (3) - lipakete tsa karete.

Matlapa a tšoeu, a pota-potile, a sephara, a manehiloe ka thipa 'me a na le mola o le mong ka lehlakoreng le leng.

Bahlomphehi: cellcose ea microcrystalline, starch, povidone, sodium methylparaben, colloidal silicon dioxide (aerosil), magnesium stearate, sodium starch glycolate, talc, metsi a hloekisitsoeng.

20 likhomphutha. - Mabokose (2) - lipakete tsa karete.
20 likhomphutha. - lithutsoana (3) - lipakete tsa karete.

Matlapa a tšoeu, a pota-potile, a sephara, a manehiloe ka thipa 'me a na le mola o le mong ka lehlakoreng le leng.

Bahlomphehi: cellcose ea microcrystalline, starch, povidone, sodium methylparaben, colloidal silicon dioxide (aerosil), magnesium stearate, sodium starch glycolate, talc, metsi a hloekisitsoeng.

20 likhomphutha. - Mabokose (2) - lipakete tsa karete.
20 likhomphutha. - lithutsoana (3) - lipakete tsa karete.

DIABINAX - litla-morao

Ho tsoa tsamaisong ea endocrine: hypoglycemia (e nang le overdose le / kapa lijo tse sa lekaneng).

Boitšoaro bo kulisang: lekhopho la letlalo, urticaria, pruritus.

Ho tsoa ts'ebetsong ea tšilo ea lijo: ka seoelo - anorexia, ho nyekeloa, ho hlatsa, lets'ollo, maikutlo a ho imeloa kapa ho opeloa ke bohloko karolong ea epigastric.

Ho tsoa ho sistimi ea hemopoietic: thrombocytopenia, leukopenia kapa agranulocytosis, anemia (hangata e fetoha).

Litaelo tse ikhethang bakeng sa ho nka DIABINAX

Kalafo ea Diabinax e etsoa hammoho le lijo tse nang le khalori e tlase e tlaase.

Nakong ea kalafo, o lokela ho lekola khafetsa boemo ba glycemia le ka mor'a ho ja.

Ka tlhokomeliso, lithethefatsi li lokela ho sebelisoa ho bakuli ba nang le bothata ba ho hloloheloa ha adrenal, mafu a tšoelesa ea qoqotho (e nang le ts'oaetso), pyelonephritis e sa foleng le ho lemalla joala.

Tabeng ea likotsi tse mpe, mafu a tšoaetsanoang, ts'ebetso ea ts'ebetso ea ts'ebetso ea bongaka, monyetla oa ho sebelisa litokisetso tsa insulin o lokela ho nahaneloa.

Phetoho ea tekanyetso ea hlokahala bakeng sa ho fetella hoa mmele le maikutlo, phetoho ea lijo.

Tabeng ea ho itima lijo kapa ho noa joala, menyetla ea ho ba le hypoglycemia ea eketseha.

Tšusumetso ho bokhoni ba ho khanna makoloi le litsamaiso tsa taolo

Nakong ea kalafo, ha ho khothalletsoe ho etsa lintho tse hlokang ho tsepamisa maikutlo le karabelo e potlakileng.

Contraindication

Hypersensitivity, mofuta oa 1 lefu la tsoekere, lefu la tsoekere, lefu la tsoekere, letšollo, ho tepella ho hoholo le / kapa ho se sebetse hantle, boimana, ho lactation, tlasa lilemo tse 18. Maemo a tsa bongaka a atisang ho hloka ho tsamaisoa ha insulin (ho kenella ka matla le ho lemala, ho chesa haholo, mafu a tšoaetsanoang ka febrile syndrome), bokhoba ba joala, botsofe.

Mokhoa oa ho sebelisa: litekanyetso le kalafo

Ka hare, nakong ea lijo, tekanyetso ea pele ea letsatsi le letsatsi ke 80 mg, tekanyetso e tloaelehileng ea letsatsi le letsatsi ke 160-320 mg (bakeng sa litekanyetso tse peli, hoseng le mantsiboea). Tekanyetso ena e itšetleha ka lilemo, ho teba ha lefu la tsoekere, ho tebela ha glucose ea mali le lihora tse peli ka mor'a ho ja.

Matlapa a ntlafalitsoeng a 30 mg a nkoa hang ka letsatsi le lijo tsa hoseng. Haeba moriana o hlotsoe, ka letsatsi le hlahlamang lethalano ha lea lokela ho eketsoa. Motsoako oa pele o khothalelitsoeng ke 30 mg (ho kenyelletsoa batho ba fetang 65). Phetoho e 'ngoe le e' ngoe ea kokoana-hloko e latelang e ka etsoa kamora bonyane libeke tse peli. Tekanyetso ea letsatsi le letsatsi ha ea lokela ho feta 120 mg. Haeba mokuli a kile a fumana kalafo ka sulfonylureas e nang le T1 / 2 e telele (mohlala, chlorpropamide), ho lekola ka hloko (libeke tse 1-2) ho hlokahala ho qoba hypoglycemia ka lebaka la ts'ebetso ea litlamorao tsa eona.

Sekhahla sa litekanyetso tsa bakuli ba tsofetseng kapa ho bakuli ba nang le bothata bo fokolang ba ho hlaphoheloa ha reiti (CC 15-80 ml / min) se tšoana le se kaholimo.

Hammoho le insulin, 60-180 mg e khothalletsoa letsatsi lohle.

Sebaka sa tokollo ea Diabinax, sephutheloana sa lithethefatsi le sebopeho.

Matlapa a tšoeu, a pota-potile, a sephara, a manehiloe ka thipa 'me a na le mola o le mong ka lehlakoreng le leng.

1 tab
gliclazide
20 mg
-«-
40 mg
-«-
80 mg

Baeti: microcrystalline cellulose, starch, povidone, sodium methyl paraben, colloidal silicon dioxide (aerosil), magnesium stearate, sodium starch glycolate, talc, metsi a hloekisitsoeng.

20 likhomphutha. - Mabokose (2) - lipakete tsa karete.
20 likhomphutha. - lithutsoana (3) - lipakete tsa karete.

TLHOKOMELISO EA TLHALOSO EA SEBETSO.
Tlhahisoleseling eohle e fanoeng e hlahisoa feela bakeng sa ho tloaelana le moriana, o lokela ho buisana le ngaka ka monyetla oa ho e sebelisa.

Litla-morao tsa Diabinax:

Ho tsoa ts'ebetsong ea tšilo ea lijo: ka seoelo - anorexia, ho nyekeloa, ho hlatsa, lets'ollo, bohloko ba epigastric.

Ho tsoa ho sistimi ea hemopoietic: maemong a mang - thrombocytopenia, agranulocytosis kapa leukopenia, anemia (hangata e fetoha).

Ho tsoa tsamaisong ea endocrine: e nang le overdose - hypoglycemia.

Boitšoaro bo kulisang: lekhopho la letlalo, ho hlohlona.

Litaelo tse ikhethang bakeng sa ts'ebeliso ea Diabinax.

Gliclazide e sebelisetsoa ho alafa mellitus e sa itšetleheng ka insulin hammoho le lijo tse nang le khalori e tlase e tlaase.

Nakong ea kalafo, o lokela ho lekola khafetsa boemo ba tsoekere maling maling ka mpeng e se nang letho le ka mor'a ho ja, ho fetoha ha maemo a letsatsi le letsatsi ka bongata.

Maemong a ts'ebetso ea ts'ebetso ea bongaka kapa ho bola ha lefu la tsoekere, ho hlokahala hore u nahane ka monyetla oa ho sebelisa litokisetso tsa insulin.

Ka nts'etsopele ea hypoglycemia, haeba mokuli a le teng, ho na le glucose (kapa tharollo ea tsoekere) kahare. Bakeng sa tahlehelo ea kelello, glucose e kenang kapa glucagon sc, intramuscularly kapa intravenous e tsamaisoa. Kamora ho hlaphoheloa kelellong, ho bohlokoa ho fa mokuli lijo tse nang le lik'habohaedreite e le ho qoba tsoelopele ea hypoglycemia.

Ka tšebeliso e ts'oanang ea gliclazide e nang le verapamil, ho hlokahala hore ho hlahlojoe maemo a tsoekere ea mali kamehla, ka acarbose, ho hlahlojoa ka hloko le ho lokisoa ha litekanyetso tsa litekanyetso tsa li-hypoglycemic agents.

Tšebeliso e tšoanang ea gliclazide le cimetidine ha e khothalletsoe.

Tšebelisano ea Diabinax le lithethefatsi tse ling.

Phello ea hypoglycemic ea gliclazide e na le tšebeliso ea ts'ebeliso e le 'ngoe ka lintho tse tsoang ho pyrazolone, salicylates, phenylbutazone, lithethefatsi tsa antibacterial sulfonamide, theophylline, caffeine, MAO inhibitors.

Ho sebelisoa ka nako e le 'ngoe ha ba khethang beta-blockers ho eketsa monyetla oa ho ntšetsa pele hypoglycemia, hape ho ka koala masesaane le ho tsitsinyeha hoa letsoho, tšobotsi ea hypoglycemia, leha ho rohakana ho ka eketseha.

Ka tšebeliso e tšoanang ea gliclazide le acarbose, ho na le phello e matla ea hypoglycemic.

Cimetidine e eketsa bongata ba gliclazide ho plasma, e ka bakang hypoglycemia (khatello ea maikutlo ea CNS, letsoalo le sa sebetseng).

Ka tšebeliso e tšoanang le GCS (ho kenyelletsa le mefuta ea litekanyetso bakeng sa ts'ebeliso ea kantle), diuretics, barbiturates, estrogens, progestin, lithethefatsi tse kopaneng tsa estrogen-progestogen, diphenin, rifampicin, phello ea hypoglycemic ea glyclazide e fokotsehile.

Litlamorao

Hypoglycemia (e khahlanong le regimen ea dosing le lijo tse sa lekaneng): hlooho ea hlooho, ho ikutloa o khathetse, tlala, ho fufuleloa ho eketsehileng, bofokoli bo matla, ho akheha, ho otsela, ho hloka boroko, ho ferekana, ho tšoenyeha, ho teneha, ho se tsotelle, ho sitoa ho tsepamisa mohopolo le ho lieha ho arabela, khatello ea maikutlo, ho sitoa ho bona, ho ferekana, ho thothomela, ho ferekana kelellong, ho ferekana kelellong, ho tsekela, ho ikutloa u se na thuso, ho lahleheloa ke boitšoaro, ho ferekana, ho akheha, khatello ea maikutlo, ho se tsebe, ho phefumoloha ho sa tsitsang, sconces dicardia.

Ho tsoa ho tsamaiso ea tšilo ea lijo: dyspepsia (ho nyekelwa ke pelo, lets'ollo, maikutlo a boima ho epigastrium), ho fokotseha takatso ea lijo - matla a fokotseha ka lijo, ka seoelo - ho hlohlona ha sebete "(cholestatic jaundice, ts'ebetso e eketsehang ea transaminase ea" sebete ").

Ho tsoa lithong tsa hemopoietic: thibelo ea masapo a hematopoiesis (anemia, thrombocytopenia, leukopenia).

Litla-morao: Ho otla, urticaria, lekhopho la maculopapular.

Tse ling: ho halefisoa ke letlalo le mucous membrane ea bongoana. Matšoao: hypoglycemia, ho akheha ka letsoalo, ho ferekana kelellong.

Phekolo: haeba mokuli a hlokahalletse, nka tsoekere kahare, a e-na le bothata ba ho se tsebe - ho hlahisa tharollo ea hypertonic dextrose (40%), 1-2 mg ea glucagon / m, taolo ea khatello ea glucose ea mali ka mor'a metsotso e meng le e meng e 15, le boikemisetso ba pH, urea, creatinine, le li-elektrone tsa mali. Kamora ho hlaphoheloa kelellong, ho bohlokoa ho fa mokuli lijo tse nang le lik'habohaedreite tse bonolo tse tsoang habonolo (molemong oa ho qoba tsoelopele ea hypoglycemia). Ka lefu la mokokotlo la mokokotlo, mannitol le dexamethasone.

Fomu ea tokollo, sebopeho le sephutheloana

Matlapa a tšoeu, a pota-potile, a sephara, a manehiloe ka thipa 'me a na le mola o le mong ka lehlakoreng le leng.

Baeti: microcrystalline cellulose, starch, povidone, sodium methylparaben, colloidal silicon dioxide (aerosil), magnesium stearate, sodium starch glycolate, talc, metsi a hloekisitsoeng.

20 likhomphutha. - Mabokose (2) - lipakete tsa karete ea likarete. li-20 likhomphutha. - lithutsoana (3) - lipakete tsa karete.

Matlapa a tšoeu, a pota-potile, a sephara, a manehiloe ka thipa 'me a na le mola o le mong ka lehlakoreng le leng.

Baeti: microcrystalline cellulose, starch, povidone, sodium methylparaben, colloidal silicon dioxide (aerosil), magnesium stearate, sodium starch glycolate, talc, metsi a hloekisitsoeng.

20 likhomphutha. - Mabokose (2) - lipakete tsa karete ea likarete. li-20 likhomphutha. - lithutsoana (3) - lipakete tsa karete.

Matlapa a tšoeu, a pota-potile, a sephara, a manehiloe ka thipa 'me a na le mola o le mong ka lehlakoreng le leng.

Baeti: microcrystalline cellulose, starch, povidone, sodium methylparaben, colloidal silicon dioxide (aerosil), magnesium stearate, sodium starch glycolate, talc, metsi a hloekisitsoeng.

20 likhomphutha. - Mabokose (2) - lipakete tsa karete ea likarete. li-20 likhomphutha. - lithutsoana (3) - lipakete tsa karete.

Sebopeho le mofuta oa tokollo

Letlapa le le leng le na le 20, 40 kapa 80 mg glycoslide, hammoho le li-excipients (MCC, starch, povidone, sodium methyl paraben, colloidal silicon dioxide / aerosil, magnesium stearate, sodium starch glycolate, talc, metsi a hloekisitsoeng). ., ka karete ea likarete tse 6 tsa karete.

Tekanyetso le tsamaiso

Ka hare, metsotso e 30-60 pele ho lijo makhetlo a 2 ka letsatsi (hoseng le mantsiboea).Tekanyetso e khethoa ka bonngoe, ho latela lilemo tsa mokuli, lipontšo tsa kliniki ea lefu lena le boemo ba ho itima lijo glycemia le lihora tse peli ka mor'a ho ja. Ka tloaelo, tekanyetso ea pele ea letsatsi le letsatsi ke 80 mg, karolelano ke 160 mg / letsatsi, 'me boholo ke 320 mg / letsatsi.

Bophelo ba sethethefatsi sa Diabinax

Se ke oa sebelisa kamora letsatsi la ho felloa ke nako le bontšitsoeng ka har'a sephutheloana.

Tlohela maikutlo a hau

Lenaneo la Hona Joale la Litaba tsa Tlhokahalo, ‰

Lithethefatsi tse Ngotsoeng tsa Bohlokoa le Tse Hlokahalang

Setifikeiti sa ho ngolisa Diabinax

• P N014190 / 01

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Lintho tse ling tse ngata tse khahlang

Litokelo tsohle li sirelelitsoe.

Ts'ebeliso ea thepa ea khoebo ha e lumelloe.

Tlhahisoleseling ena e etselitsoe litsebi tsa bongaka.

DIABINAX: DOSELE

Tekanyo ea lithethefatsi e beoa ka bonngoe, ho latela lilemo tsa mokuli, lipontšo tsa kliniki ea lefu lena le boemo ba ho itima lijo ha glycemia le lihora tse peli ka mor'a ho ja. Motsoako oa mantlha oa letsatsi le letsatsi ke 80 mg, karolelano ea letsatsi le letsatsi ke 160 mg, 'me boholo ba letsatsi le letsatsi ke 320 mg. Diabinax e nooa ka molomo makhetlo a 2 / ka letsatsi (hoseng le mantsiboea) metsotso e 30-60 pele ho lijo.

Bongata

Matšoao: pallor ea letlalo, tachycardia, tlala, ho fufuleloa ho feteletseng, ho thothomela, maemong a tebileng - letsoalo le sa sebetseng.

Phekolo: haeba mokuli a hlokometse, tsoekere kapa tharollo ea tsoekere e laetsoe ke molomo. Maemong a ho lahleheloa ke kelello, tharollo ea glucose ea 40% kapa glucagon s / c, i / m, iv e tsamaisoa iv. Kamora ho hlaphoheloa kelellong, ho bohlokoa ho fa mokuli lijo tse nang le lik'habohaedreite e le ho qoba tsoelopele ea hypoglycemia.

DIABINAX: MAHLOMOLA MAHALA

Ho tsoa tsamaisong ea endocrine: hypoglycemia (e nang le overdose le / kapa lijo tse sa lekaneng).

Boitšoaro bo kulisang: lekhopho la letlalo, urticaria, pruritus.

Ho tsoa ho tsamaiso ea tšilo ea lijo: ka seoelo - ho ipolaisa tlala, ho nyekeloa, ho hlatsa, lets'ollo, maikutlo a ho imeloa kapa ho opeloa ke bohloko karolong ea epigastric.

Ho tsoa ho sistimi ea hemopoietic: thrombocytopenia, leukopenia kapa agranulocytosis, anemia (hangata e fetoha).