Tlhahlobo ea meriana ea cholesterol e holimo

E ile ea etsahala hore nakong ea tlhahlobo e latelang ea 'mele tlhahlobong ea mali a biochemical, ke ile ka fumana cholesterol e phahameng, eseng e ngata, eseng 7,3.

K'holeseterole e phahamisitsoeng ke kotsi ea ho hlaseloa ke pelo le stroke, hobane cholesterol e sekamela ho khomaretseng marako a methapo ea mali mme e nyenyefalitse matla a eona, ho ekelletsa moo, mali a nang le k'holeseterole e phahameng a fetoha viscous. Maemo ana a mabeli a ka lebisa ho senyeha ha sekepe kapa ho phatloha ha sona. Ho hlonama ...

Ngaka, ho latela liphetho tsa liteko, e ile ea mpha kalafo - ho nka moriana ho theola cholesterol Atoris, ka tekanyetso ea 10 mg, hang ka letsatsi le ho fumana tlhahlobo ea cholesterol libeke tse peli kamora ho qala ha moriana.

• Atoris (Atorvastatin) ke lithethefatsi tse tsoang sehlopheng sa li-statins.
• Moqapi - Krka, Slovenia
• Palo ea litafole ka pakete e ngoe le e ngoe - 30 likhomphutha.
• Theko - 358 li-ruble

Matlapa a manyane, a masoeu

Atoris e laeloa k'holeseterole e phahameng ea mali e le hore e theole cholesterol e tloaelehileng, ebe e e boloka e le maemong a tloaelehileng.

Matšoao

• hyperlipidemia ea mantlha Mefuta ea IIa le IIb ho latela sehlopha sa Frederickson, ho kenyeletsoa polygenic hypercholesterolemia, Hyperlipidemia e tsoakiloeng, heterozygous Familia hypercholesterolemia, ho theola boemo ba kakaretso k'holeseterole, apolipoprotein B, LDL k'holeseterole, triglycerides mading
• Hypsygous hypercholesterolemia ea lelapa, ho theola boemo ba kakaretso k'holeseterole, apolipoprotein B, LDL k'holeseterole,

Contraindication

• skeletal mesia
• hypersensitivity ho atorvastatin, metsoako e meng ea Atoris, kapa motsoako oa eona,
• ho hloleha ha sebete,
• pathology ea sebete ka sethaleng se thata (ho kenyeletsa lekhoba la tahikapa mafolofolo a sa folenghepatitis,
• khaello ea lactase, ho se mamelle lactose le lefu la tsoekere la glucose-galactose,
• Cirrhosis ea limelo tse fapaneng
• boemo bo phahameng hepatic transaminases tsa tlhaho e sa tsejoeng, e phahametseng makhetlo a 3 ho feta tloaelo,
• lilemo tse 18
• linakosefubale ea boimana.

Joalokaha ho laetsoe ke setsebi sa bongaka, ke ile ka nka Atoris 10 mg hang ka letsatsi. O ka nka moriana ona ka nako efe kapa efe ea letsatsi, empa o hloka ho o etsa ka nako e tšoanang.

Kamora libeke tse peli ke ile ka fana ka tlhahlobo ea taolo ea mali, a bonts'a hore boemo ba cholesterol maling a ka bo ile ba fokotseha 'me ea eba ntho e tloaelehileng - 5.7.

Tloaelo ea cholesterol maling

Ho boloka phello e fumanoeng, ke ile ka abeloa ho tsoela pele ho nka Atoris ka tekanyo e le ngoe bakeng sa libeke tse ling tse peli, ebe ke theola lethalinyana ho 5 mg hang ka letsatsi.

Ehlile, ho bonolo, ho nka lipilisi le voila, liteko li tloaelehile. Empa rea ​​utloisisa hore haeba cholesterol e phahame, joale o tlameha ho fetola lijo tsa hau pele. Li-sausage tse hantle, brisket, waffles, ke ne ke phetse hantle le uena!

Atoris ea lithethefatsi o ile a etsa ntho e ngoe le e ngoe eo ke neng ke e lebelletse ho eena. O ile a theola boemo ba cholesterol kapele ka potlako 'me a se ke a nkhatholla kapa a mpefatsa, pakete e le' ngoe e ne e lekane bakeng sa khoeli ea ho e nka.

U sebelisa litafole, u ka theola cholesterol kapele, empa ho e boloka e le boemong bo sireletsehileng ho molemo ka phepo e nepahetseng, hobane ho nka litafole tsa bophelo ka tsela e itseng ha ho hotle haholo.

Ke leboha e mong le e mong ea balileng tlhahlobo ea ka, le be le letsatsi le letle!

Statins: kamoo ba etsang lintho, matšoao le li-contraindication, tlhahlobo ea lithethefatsi, hore na ho tla etsoa eng

Ka lilemo tse ngata o sa sebetsane ka katleho le CHOLESTEROL?

Hlooho ea Setsi: “U tla makala hore na ho bonolo hakae ho theola cholesterol ka ho e nka letsatsi le letsatsi.

Cholesterol, kapa cholesterol, ke ntho e etsang mesebetsi ea bohlokoa 'meleng oa motho. Tsena li kenyeletsa:

• Ho nka karolo e le thepa ea moaho ts'ebetsong ea bophelo ba hoo e batlang e le lisele tsohle tsa 'mele, hobane limolek'hule tsa cholesterol li kentsoe kahara membrane ea sele mme e e fa matla, ho fetoha le ho fetoha ha "fluidity",
• Ho nka karolo ts'ebetsong ea tšilo ea lijo le ho hlahisoa ha li-acids tse hlokahalang bakeng sa ho phatloha le ho kenngoa ha mafura ka har'a pampitšana ea gastrointestinal,
• Ho nka karolo ho thehoeng ha li-'mele tsa 'mele - lihormone tsa li-hormone tsa adrenal le lihormone tsa thobalano.

K'holeseterole e ngata maling e lebisa 'neteng ea hore limolek'hule tsa eona tse feteletseng li ka beoa maboteng a methapo ea mali (haholo methapo ea methapo). Ho thehoa li-plaque tsa atherosclerotic tse sitisang phallo ea mali ka har'a methapo ea mali mme ka linako tse ling, hammoho le mathetsi a mali a khomaretsoeng ho tsona, li thibela ka botlalo lumen ea sekepe, li kenya letsoho kholong ea ho otla ha pelo le ho otloa ke stroke.

Tloaelo ea k'holeseterole e felletseng maling a motho e moholo ha ea lokela ho ba ho feta 5.0 mmol / l, ho bakuli ba nang le lefu la pelo le sa feteng 4,5 mmol / l, le ho bakuli ba nang le myocardial infarction ha ho feta 4.0 mmol / l.

Li-statins ke eng, 'me li sebetsa joang?

Maemong moo mokuli a nang le kotsi e eketsehileng ea ho ba le myocardial infarction ka lebaka la mathata a atherosulinosis le cholesterol metabolism, o bontšoa tšebeliso ea nako e telele ea lithethefatsi tse fokotsang lipid.

Statins ke lithethefatsi tsa hypolipidemic (lipid-lowing), mohato oa ts'ebetso oo e leng ho thibela enzyme e khothalletsang sebopeho sa cholesterol. Ba sebetsa ka molao-motheo oa "ha ho enzyme - ha ho na cholesterol." Ntle le moo, ka lebaka la methati e sa tsamaellaneng, ba kenya letsoho ho ntlafatseng karolo e senyehileng ea methapo ea mali sethaleng ha atherosulinosis e ntse e sa khonehe ho sibolla, empa ho hlahisoa ha cholesterol maboteng e se e qalile - qalong ea atherosclerosis. Li boetse li na le phello e molemo litlamorao tsa mali tsa rheological tsa mali, li fokotsa ho bonoa, e leng ntho ea bohlokoa e thibelang ho thehwa ha methapo ea mali le ho hokahana ha eona le lipampiri.

Tse sebetsang ka ho fetisisa li tsejoa e le karolo ea morao-rao ea li-statins, tse nang le atorvastatin, cerivastatin, rosuvastatin le pitavastatin e le ntho e sebetsang. Lithethefatsi tsa moloko oa morao-rao ha li fokotse boemo ba "cholesterol" e mpe feela, empa li boetse li eketsa litaba tsa "tse ntle" maling. Tsena ke li-statins tse ntle ho fihla joale, mme phello ea ts'ebeliso ea bona e se e le teng khoeling ea pele ea ts'ebeliso e sa feleng. Statins e beoa hanngoe ka letsatsi bosiu, e ka kopanngoa le letlapa le le lithethefatsi tse ling tsa pelo.

Ts'ebeliso e ikemetseng ea li-statins ntle le ho buisana le ngaka ha e amohelehe, hobane pele o nka moriana ho hlokahala ho tseba hore na cholesterol e kae maling. Ho feta moo, haeba boemo ba cholesterol bo ka tlase ho 6.5 mmol / l, nakong ea likhoeli tse tseletseng o lokela ho leka ho e theola ka lijo, bophelo bo botle, mme feela ha mehato ena e sa sebetse, ngaka e etsa qeto ea ho beoa ha li-statins.

Ho tsoa ho litaelo tsa ho sebelisa li-statins, o ka totobatsa lintlha tsa sehlooho:

Matšoao a li-statin

Letšoao le ka sehloohong ke hypercholesterolemia (cholesterol e phahameng) ka ho se sebetse hantle hoa mekhoa eo e seng ea lithethefatsi le hypercholesterolemia ea ho hloka lijo.

Ho beha li-statins ho tlamehile ho batho ba nang le hypercholesterolemia e amanang le mafu a latelang, hobane tšebeliso ea bona hammoho le lithethefatsi tse ling tse fanoeng ke ngaka e fokotsa haholo kotsi ea lefu la pelo le tšohanyetso:

• Batho ba kaholimo ho lilemo tse 40 ba kotsing e kholo ea lefu la pelo,
• Lefu la pelo, "angina pectoris"
• Myocardial infarction
• Aorto-coronary bypass surge kapa ho beoa ka thata bakeng sa ischemia ea myocardial,
• Stroke
• Ho Nona Haholo
• Lefu la tsoekere
• Nyeoe ea lefu la pelo ea tšohanyetso ho beng ka motho ba haufi le ba ka tlase ho lilemo tse 50.

Contraindication

Contraindication e kenyelletsa ts'ebetso ea sebete e sa sebetseng (hepatitis, cirrhosis) sethaleng se sebetsang, karohano ea ho kulisa le tsamaiso ea pele ea lithethefatsi. Lipalo ha lia lokela ho nkuoa ke basali baimana le ba anyesang, hammoho le basali ba lilemo tsa ho tsoala ba sa sebeliseng mekhoa e tšepahalang ea ho thibela pelehi. Statins ha e ame mefuta e meng ea metabolism (protheine, carbohydrate, purine metabolism), ka hona e ka sebelisoa ho bakuli ba nang le lefu la tsoekere, gout le mafu a mang a kopaneng.

Litlamorao

Tlas'a 1% ea bakuli ba nkang li-statins nako e telele mme ba tsoelapele ho ts'oaroa ke mala, ho ts'oaroa ke boroko, ho fokola hoa kutlo, ho fokotseha ha tatso, ho nyekeloa ke pelo, ho fokotseha ho hoholo le ho eketseha ha khatello ea mali, ho fokotseha ha methapo ea mali, makhopho a pelo. , bohloko ba ka mpeng, ho nyekeloa ke pelo, mokokotlo o sa tsitsang, ho rota khafetsa, ho fokotseha ha potency, bohloko mesifa le manonyeletso, rhabdomyolysis (Tšenyo ea mesifa ea mesifa), ho fufuleloa ho hoholo, ho hanoa ke mefuta.

Bakuli ba fetang 1% ba na le ho ba le lits'ila, ho nyekeloa ke pelo, ho opeloa ke pelo, ho omella, komello ea nko, edema ea moea, ho eketsa matla a letlalo ho chaba, ho fetoha ha letlalo - ho hlohlona, ​​bofubelu, eczema.

Na li-statins li ka kopantsoe le lithethefatsi tse ling?

Ho latela likhothaletso tsa WHO le Mokhatlo oa Pelo ea Amerika, li-statin ke setlhare sa bohlokoa kalafong ea lefu la pelo le nang le kotsi e kholo ea mathata le infarction ea myocardial. Ho fana ka litlhare tse le 'ngoe ho theola cholesterol e tlase ha ho na ho lekana, ka hona, lithethefatsi tse hlokahalang li kenyelelitsoe maemong a kalafo - tsena ke beta - blockers (bisoprolol, atenolol, metoprolol, jj.) enalapril, perindopril, quadripril, jj.) le li-statins. Ho entsoe lithuto tse ngata tse pakang hore tšebeliso ea lithethefatsi tsena ka tsela e sireletsehileng e bolokehile. Ho feta moo, ka ho kopanya, ho etsa mohlala, pravastatin le aspirin ka har'a letlapa le le leng, menyetla ea ho ba le myocardial infarction (7.6%) e fokotsoa haholo ha e bapisoa le ho sebelisa lithethefatsi u le mong (hoo e ka bang 9% le 11% ha u nka pravastatin le aspirin, ka ho latellana).

Babali ba rona ba sebelisitse Aterol ka katleho ho theola cholesterol. Ha re bona sehlahisoa sena se tsebahala, re nkile qeto ea ho e ela hloko.

Kahoo, haeba li-statin li ne li laetsoe bosiu pele ho moo, ke hore, ka nako e arohaneng le ho nka lithethefatsi tse ling, sechaba sa bongaka sa lefats'e se se se fihlela qeto ea hore ho sebelisa lithethefatsi tse kopaneng ka har'a letlapa le le leng ho loketse haholo. Ho mefuta ena, lithethefatsi tse bitsoang polypill li ntse li lekoa hona joale, empa tšebeliso ea tsona e le ngata. U se u sebelisitse lithethefatsi ka katleho ka motsoako oa atorvastatin le amlodipine - caduet, duplexor.

Ka sekhahla se phahameng sa cholesterol (ho feta 7.4 mmol / l), ts'ebeliso e kopaneng ea li-statins tse nang le lithethefatsi e ka khona ho e fokotsa ho tsoa sehlopheng se seng - fibrate. Kopo ena e lokela ho etsoa feela ke ngaka, e lekola ka hloko likotsi tsa litla-morao.

U ke ke oa kopanya ho nka li-statin le lero la grapefruit, kaha e na le lintho tse fokotsang metabolism ea 'mele' me li eketsa bongata ba tsona maling, bo aparetsoeng ke nts'etsopele ea maikutlo a mabe a nang le chefo.

Hape, ha ua lokela ho nka meriana e joalo ka joala, lithibela-mafu, haholocacithromycin le erythromycin, kaha sena se ka ba le phello e chefo ho sebete. Lithibela-mafu tse ling tse kopantsoeng le meriana ho theola cholesterol e bolokehile. Ho lekola ts'ebetso ea sebete, ho hlokahala ho etsa tlhahlobo ea mali ea biochemical likhoeli tse ling le tse ling tse tharo le ho tseba hore na li-enzyme tsa sebete (AlAT, AsAT) li joang.

Kotsi le Molemo - Pros le Cons

Ha u sebelisa meriana e boletsoeng ke ngaka, mokuli e mong le e mong o nahana ka ho nepahala ha litlatsetso.Ho nka li-statins ha ho joalo, haholo-holo hobane hangata u ka utloa ka likotsi tsa lithethefatsi tsena. Pono ena e ka felisoa, hobane lilemong tsa morao tjena ho entsoe meriana ea morao-rao e tlisang melemo e mengata ho feta kotsi.

Melemo ea ho nka li-statins

1. Phokotso ea 40% ea lefu la pelo lilemong tse hlano tse qalang,
2. Phokotso ea 30% kotsing ea ho tšoaroa ke lefu la stroke le lefu la pelo,
3. Ho sebetsa hantle - ho theola cholesterol ka ts'ebeliso e sa khaotseng ka 45 - 55% ea boemo bo phahameng ba qalong. Ho hlahloba katleho, mokuli o lokela ho etsa tlhahlobo ea mali khoeli le khoeli bakeng sa cholesterol,
4. Tšireletseho - ho nka mofuta oa morao-rao oa li-statin ka tekanyetso ea kalafo ha e na phello e matla 'meleng oa mokuli, mme kotsi ea litlamorao e tlase haholo. Boithuto bo bongata bo nkang nako e telele ea ho hlahloba bakuli ba 'nileng ba nka li-statin nako e telele bo bontšitsoe hore ts'ebeliso ea bona e ka tsosa kholo ea lefu la tsoekere la mofuta oa 2, lefu la sebete, lefu la ho bola le ho senyeha kelellong. Leha ho le joalo, sena se hlakotsoe mme se paka hore mafu a joalo a hlaha ka lebaka la mabaka a mang. Ho feta moo, lipatlisiso tse entsoeng ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 ho tloha ka 1996 li bonts'itse hore kotsi ea ho ba le mathata a lefu la tsoekere joalo ka lefu la tsoekere la polyneuropathy, retinopathy e fokotsehile ka 34% le 40%, ka ho latellana.
5. Palo e kholo ea li-analogu tse nang le ntho e le 'ngoe e sebetsang ka mekhahlelo e fapaneng ea theko, e thusang ho khetha moriana o nahanela bokhoni ba lichelete ba mokuli.

Likotsi tsa ho nka li-statins

• Litsenyehelo tse phahameng tsa litokisetso tse ling tsa mantlha (sefapano, rosucard, leskol forte). Ka lehlohonolo, thekiso ena e tlosoa habonolo ha e tlosa lithethefatsi ka ntho e le 'ngoe e sebetsang ka analogue e theko e tlaase.

Ho joalo, melemo e joalo le melemo e ke keng ea bapisoa e lokela ho tsotelloa ke mokuli ea nang le matšoao a ho amoheloa, haeba a belaela hore na ho bolokehile ho nka li-statins mme o lekola ka hloko melemo le mathata.

Tlhatlhobo ea lithethefatsi

Lethathamo la lithethefatsi tseo hangata li fuoeng bakuli li hlahisoa ka har'a tafole:

Lebitso la moriana, lihlahisoa tsa ntho e sebetsang (mg)

Theko e lekantsoeng, rub

Moloko oa ka SimvastatinVasilip (10, 20 kapa 40)Slovenia355 — 533 Simgal (10, 20 kapa 40)Czech Republic, Isiraele311 — 611 Simvakard (10, 20, 40)Rephabliki ea Czech262 — 402 Simlo (10, 20, 40)India256 — 348 Simvastatin (10, 20 kapa 40)Serbia, Russia72 — 177 PravastatinLipostat (10, 20)Russia, USA, Italy143 — 198 LovastatinHolletar (20)Slovenia323 Cardiostatin (20, 40)Russia244 — 368 Moloko oa II FluvastatinLeskol Forte (80)Switzerland, Spain2315 Moloko oa III AtorvastatinLiptonorm (20)India, Russia344 Liprimar (10, 20, 40, 80)Jeremane, USA, Ireland727 — 1160 Torvacard (10, 40)Rephabliki ea Czech316 — 536 Atoris (10, 20, 30, 40)Slovenia, Russia318 — 541 Tulip (10, 20, 40)Slovenia, Sweden223 — 549 Moloko oa IV RosuvastatinCrestor (5, 10, 20, 40)Russia, Great Britain, Jeremane1134 – 1600 Rosucard (10, 20, 40)Rephabliki ea Czech1200 — 1600 Rosulip (10, 20)Hungary629 – 913 Tevastor (5, 10, 20)Isiraele383 – 679 PitavastatinLivazo (1, 2, 4 mg)Italy2350

Leha ho na le keketseho e pharalletseng joalo ka litšenyehelo tsa li-statins, li-analogu tse theko e tlase ha li tlase haholo ho lithethefatsi tse theko e boima. Ka hona, haeba mokuli a sa khone ho reka sethethefatsi sa pele, ho ka khoneha ho se nkela sebaka joalo ka ha ho laetsoe ke ngaka ka se tšoanang le se theko e tlase haholo.

A na nka fokotsa cholesterol ea ka ntle le lipilisi?

Phekolo ea atherosulinosis e le ponahatso ea "cholesterol" e mpe e feteletseng 'meleng, lengolo la ngaka la pele e lokela ho ba likhothaletso tsa khalemelo ea bophelo, hobane haeba boemo ba cholesterol bo sa phahame haholo (5.0 - 6.5 mmol / l), mme kotsi ea mathata a pelo e tlase haholo, o ka leka etsa hore e tloaelehileng le eona ka thuso ea mehato e joalo:

• Phepo e nepahetseng, mokhatlo o hlophisitsoeng oa mofuta oa lijo ntle le lijo tse mafura, tse halikiloeng.Ho khethoa lijana ka mochini o phehiloeng, o phehiloeng, sechu. Ts'ebeliso ea mahe (li-yolks), nama ea mefuta e nang le mafura, offal (sebete le liphio), lihlahisoa tsa lebese li na le moeli. Ho bohlokoa hore u se khetholle lihlahisoa tsena, empa u li sebelise feela ka tekanyo ho latela melaoana ea phepo e nepahetseng, kaha 'mele o hloka k'holeseterole e le thepa ea kaho ea bokong, sebete, lisele tsa mali le litho tse ling. Ka hona, u se ke ua ja lijo tse nang le litaba tsa teng ho hang.
• Ts'ebetso ea 'mele e loketseng boemo ba methapo ea pelo (ho tsamaea, boikoetliso, ts'ebetso ea moea o mocha, jj.).
• Ho hana mekhoa e mebe, joalo ka ha bo-ramahlale ba pakile hore tšebeliso e mpe ea joala le ho tsuba li eketsa cholesterol ea mali.

Lijo tse ling li na le seo ho thoeng ke tlhaho ea tlhaho. Har'a lihlahisoa tsena, konofolo le turmeric ke tsona tse ithutoang haholo. Litokisetso tsa oli ea tlhapi li na le li-acid tse omega 3, tse thusang ho etsa hore metabolism ea cholesterol e be teng 'meleng. O ka nka oli ea tlhapi, e rekiloeng ka har'a k'hemiste, kapa o ka pheha lijana tsa tlhapi (trout, salmon, salmon, jj) makhetlo a 'maloa ka beke. Ho lekantsoe boholo ba fiber ea meroho e fumanehang ka liapole, lihoete, lijo-thollo (oatmeal, harese) le linaoa.

Ha ho se na phello ea mekhoa eo e seng ea lithethefatsi, ngaka e beha e 'ngoe ea litlhare tse theolang lipid.

Qetellong, ke rata ho tseba hore, leha ho tšaba bakuli le mohopolo oa likotsi tsa li-statins, sepheo sa bona se na le mabaka a phethahetseng bakeng sa atherosclerosis e holetseng ka tšenyo ea methapo ea methapo ea kutlo, kaha lithethefatsi tsena li lelefatsa nako ea bophelo. Haeba o na le cholesterol e phahameng ea mali ntle le matšoao a ho senyeha ha methapo, joale o lokela ho ja hantle, ho tsamaea ka mafolofolo, ho phela bophelo bo phetseng hantle, mme nakong e tlang ha o na ho tlameha ho nahana ka ho nka li-statins.

Lipilisi tsa ho fokotsa cholesterol ea mali le ho hloekisa methapo ea mali

Batho ba bangata ba na le mathata a bophelo bo botle a amanang le maemo a methapo. Ka hona, o hloka ho tseba hore na lipilisi tsa cholesterol li teng le hore na li sebetsa joang.

Ha batho ba fumana cholesterol e phahameng maling a bona, batho ba bangata baa botsa: “Na lipilisi tsa cholesterol lia sebetsa kapa che?” Ho nka meriana e boletsoeng ke ngaka ho thusa ho khutlisa boemo ba methapo, methapo ea methapo le methapo, le ho tlosa li-cholesterol plaque. Hammoho le litafole, lijo le ho ikoetlisa li bohlokoa. Ka hona, ho bohlokoa ho tseba hore na ho na le lithethefatsi tse theolelang cholesterol kae? Li lokela ho nkuoa joang?

K'holeseterole e mpe

Ntho ea bohlokoa maling a motho ke cholesterol, e fumanoang hoo e batlang e le liseleng tsohle tsa sele. Vithamine D le li-enzyme tsa lihormone li hlahisoa ho eona, hape le eona e baka ho itšireletsa mafung. Cholesterol e kenya letsoho ts'ebetsong e nepahetseng ea bokong, sebete, mesifa le methapo ea methapo. Leha ho le joalo, ho tsoa ho k'holeseterole e phahameng, ho hlaha li-pathologies tsa vascular tse kotsi.

Babali ba rona ba sebelisitse Aterol ka katleho ho theola cholesterol. Ha re bona sehlahisoa sena se tsebahala, re nkile qeto ea ho e ela hloko.

• e thibela ho bokellana ha li-hydrocarbons,
• kenya letsoho ho theheng lisele tsa methapo,
• e thusa sebopeho sa bile le lihormone tse hlahisoang ke litšoelesa tsa adrenal,
• ho ameha metabolism,
• e khetholla likhoele tsa methapo
• e thusa ho monya vithamine D.

Enzyme e hlahisoa ke lisele tsa sebete, 'me liprotheine li li fetisetsa ka plasma. Ka lebaka la sena, liketane foromo, e ileng ea fetoha likarolo tsa lipoprotein kamora moo tsa fetoha.

Matla a hlahang 'meleng a ipapisitse le sebopeho sa ntho ena. Haeba li-lipoprotein tse fokolang haholo (LDL) li le teng, joale li-plaque li hlaha ka har'a likepe, kamora moo ho ka hlaha atherosclerosis.Ka ho kenella ka matla (HDL), phapanyetsano e nepahetseng ea k'holeseterole le li-acid acid e etsahala, 'me ho fella ka kotsi e fokotsehileng ea atherosclerosis.

Ho fumana boemo ba ntho ena, ho etsoa tlhahlobo ea mali a biochemical. Litloaelo tsa matšoao li fapana lipakeng tsa banna le basali, lilemo tsa motho le tsona li ama boleng. Ka halofo e matla, k'holeseterole e phahameng e lula e bonoa hangata.

Keketseho ea khoholeho ea lipoprotein tse tlaase haholo kamora lilemo tse mashome a mahlano li bonoa. Ho basali, ketsahalo ena e utloahala nakong ea ho khaotsa ho ilela khoeli.

Ka lebaka leo, ts'ebetso e kholo ea methapo ea methapo e kang ho potoloha hoa mali bokong e ka hlaha, hangata e lebisang ho myocardial infarction. Ka hona, lingaka li fana ka lipilisi ho thusa ho fokotsa cholesterol.

Ka ho otloa ke pelo kapa stroke, o ka se lumelle cholesterol ho tsoha. Kaha boiphetetso ba nts'etsopele ea li-pathologies tse phetoang bo ka eketseha.

Leha e le taba ea hore cholesterol e phahameng e kotsi haholo. Karolo ea eona ka tekanyo e lekanang e kholo, e nka karolo lits'ebetsong tsohle tsa biochemical mme e hlokahala bakeng sa bophelo ba 'mele. Ka hona, ho e boloka e le ntho e tloaelehileng ho bohlokoa, hobane ba sebelisa meriana le ho phela bophelo bo nepahetseng.

Ho theoha ha letšoao

Nutla e khethoa ke ngaka, empa e ipapisitse le:

• Ho tlohela joala, ho tsuba,
• Phokotso ea letsoai le lijo tse nang le mafura,

• thibelo ea mafura a liphoofolo, ho molemo ho ja mafura a meroho,
• fiber ea meroho, lik'habohaedreite tse rarahaneng le asiti tse polyunsaturated li lokela ho ba teng lijong.

Hoa hlokahala ho lahla soseji le lisoseji, likuku, likuku, meqolo le li-muffin. Phepo e nepahetseng e ke ke ea thusa feela ho tlosa sekhahla se phahameng, empa hape e ntlafatsa bophelo ba motho.

Ho bohlokoa ho hlokomela hore 80% ea cholesterol e thehiloe ka har'a sebete, 'me 20% e setseng e etsa lijo tse setseng. Ka hona, phepo e nepahetseng le e leka-lekaneng e tla thusa ho e tloaetse.

• ho theola boima ba 'mele
• boikoetliso ba letsatsi le letsatsi
• boloka likhalori

• ho tlohela mekhoa e mebe: joala, ho tsuba,
• Qoba khatello ea maikutlo le litšabo tse tšosang.

Ho theola ntho ena, o ka sebelisa lihlahisoa tse thehiloeng ho litlama le litlatsetso tse sebetsang. Mafura a nang le mafura a bitsoang Omega-3 polyunsaturated a thibela li-plaque hore li se ke tsa hola le ho cheka hoa mali ho ba teng.

Ho na le linako tse ling ha ho latela lijo, ho inehella joala le ho ikoetlisa nako e telele ha ho thuse cholesterol e tlase. Ebe ngaka e khothalletsa ho noa meriana e khethehileng ho theola cholesterol.

Nalane ea nts'etsopele

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Bongaka esale bo batla lithethefatsi tse theolelang cholesterol nako e telele haholo (ho tloha ka 1962). Le nakong eo ho ne ho tsebahala hore ke eena ea neng a ikarabella bakeng sa atherosclerosis feela, empa le lefu la pelo le coronary. Palo e kholo ea lithuto tsa laboratori, lilemo tse ngata tsa mosebetsi, chelete e ngata - ka mashome a lilemo tsena tsohle ha lia ka tsa hlahisa litholoana. Ho bile le mathata a mabeli. Taba ea pele, ba ne ba tšaba hore lithethefatsi tse joalo li ka ba le litlamorao tse ngata, hobane lipoprotein ke thepa ea kaho bakeng sa li-membrane tsa sele 'me ke karolo ea tsona tlhahisong ea li-acid acid le li-steroid. Haeba u hatella mofuta oa tsona, lits'ebetso tsena kaofela li tla senyeha. Taba ea bobeli, liteko mabapi le likhoto ha lia ka tsa fana ka litholoana, ho sa tsotelehe hore na ba ile ba etsa tlhahlobo ea mofuta ofe.

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Leha a bile le mathata ana, rasaense oa Mojapane Endo Akira o ile a tsoela pele ho batla moriana o tla pholosa batho ho tsoa ho cholesterol plaque, atherosclerosis le mafu a mang a pelo. Patlisiso ea hae e nkile ho tloha ka 1971 ho fihlela ka 1976. Lithuto tsa 6,000 le lilemo tse 5 - nako e ngata ho ile ha nka sehlopha sa hae ho theha statin ea pele.

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Ngaka e nang le talenta e ile ea sebetsana ka potlako le khopiso ea bobeli: ho ile ha fumaneha hore cholesterol e tloaelehile ebile e kotsi.Basebeletsi ba hatelletse karolo ea bobeli, empa 'mele oa phoofolo o ile oa lefella ho haella ha eona ka ho eketsa ea pele, e leng hore e ne e beiloe leihlo nakong ea mosebetsi oa mahlale. Ha sena se etsahala, ho ile ha fumaneha hore moriana o hlile oa sebetsa ebile o sebetsa hantle.

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Lithethefatsi tsa pele tsa statin e ne e le Kompaktin, ea ileng a tlameha ho mamella litlhaselo tse ngata. Leha e sebetsa, e ile ea tsebahala e le "carcinogenic" 'me ea emisa tlhahiso. Leha ho le joalo, mehla ea li-statins e ne e se e bulehile, mme botho bo sitoa ho bo tlohela. Ho tloha lilemong tsa bo-80 tsa XX, li tlisitse chelete e ngata ho lik'hamphani tsa meriana.

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Leha ho le joalo, bothata ba pele bo ileng ba hlaha qalong ea nts'etsopele ea lithethefatsi tsa cholesterol bo ntse bo sebetsa ho fihlela joale. Lipalo-palo li na le litlamorao tse ngata. Ka hona, lilemong tse leshome tse fetileng, nts'etsopele e mafolofolo ea lithethefatsi tse ling tse fokotsang lipid e ntse e tsoela pele.

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Tlhahisoleseling ka kakaretso

Haeba tekanyo ea cholesterol e phahameng e fumanoe nakong ea tlhahlobo le tlhahlobo ea mali, ngaka e beha litlhare tse e theolang. 'Me hangata hangata tsena ke li-statins. Lithethefatsi tse theolang lipid tse theohileng tse nang le litlamorao tse fapaneng le tsa pharmacological, tse ntlafalitsoeng lilemong tsa morao tjena, li na le litlamorao tse fokolang. Empa ts'ebetso ea bona ha e na metsi. Kamora 'kalafo, ba bone ntlafatso e fokolang maemong a bakuli. Ka hona, lingaka tse batlang ho bona matla le tsoelo-pele li lula li tšepahala ho li-inhibitors tsa tri-hydroxy-tri-methylglutaryl-CoA (lebitso la saense bakeng sa li-statins).

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Ha ba fana ka litlhare tse fokotsang k'holeseterole ho bakuli ba bona, lingaka li tlameha ho ba lemosa esale pele ka lintlha tse latelang:

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• e le ho fokotsa k'holeseterole e mpe, li-statin ka linako tse ling li tlameha ho tahoa hangata, ke hore, bophelo bohle.
• ha ho litlolo mabapi le litaelo tsa ts'ebeliso ea bona li lumelloa,
• litla-morao ha se tse ngata feela - har'a tsona ho na le tse amang haholo boiketlo ba batho le ho fokotsa bophelo.

Ka hona, ntle le taelo ea ngaka, kamora ho bala lethathamo la litla-morao, ke mokuli feela ea etsang qeto ea ho noa li-statin. Lilemong tse 'maloa tse fetileng ho ne ho se na khetho, hobane ke tsona feela lithethefatsi tse nang le ts'oaetso ea lipid. Empa boemo ba hona joale ba bongaka bo fana ka mefuta e meng: li-fibrate, li-modifera tsa lipid tse kopaneng, li-sequestrants, li-lipid metabolism li-etc. Leha ho le joalo, ts'ebetsong ea bona ba tlase haholo ho li-statins, tseo ho fihlela kajeno, ho sa natsoe liphoso tse ngata, li ntse li le baetapele ntoeng ea ho loants'oa batho ba fokolang haholo (LDL).

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Sehlopha sa ATS

Ha e le karohano mabapi le sebopeho sa lithethefatsi tse ka fokotsang cholesterol, hoo e batlang e le kaofela ha tsona li maiketsetso. Litlhare tsa litlama li kenyelletsa Lovastatin (li-mushroom tsa oyster), Polyconazole (alane ea 'moba), Guarem (linaoa tsa hyacinth) le litlatsetso tsa phepelo ea lijo, ka linako tse ling e laetsoe ho tlosoa hoa litheko tsa atherosseloticotic, empa ha li sebetse lithethefatsing tse felletseng tsa lipid-lowing.

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Fomu ea tokollo

Ho ea ka sebopeho sa tokollo, lithethefatsi tse ngata li hlahisoa e le litafole kapa likhakeletsi. Tse ling li tšoana le phofo e qhibilihang ka metsing. Ka mofuta oa liente, ho fanoa ka nicotinic acid le lithethefatsi tse ncha tsa Amerika Repatha (Repat) le Praluent, tse seng li le teng ho hlola 'maraka oa meriana.

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Lebitso la semmuso: li-inhibitors tsa tri-hydroxy-tri-methylglutaryl-CoA.

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Khoutu ea PBX: C10AA.

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Tafole e fana ka lethathamo la metsoako ea mantlha e sebetsang ea li-statin le lithethefatsi tse ntlafalitsoeng motheong oa tsona, ho bonts'a katleho ea tsona (ka liperesente tse kae ba khonang ho theola cholesterol ea mali):

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• I: Lovastatin, Simvastatin, Pravastatin,
• II: fluvastatin,
• III: Atorvastatin, Cerivastatin,
• IV: Pitavastatin, rosuvastatin.

Mosebetsi oa moloko o mong le o mong o latelang oa lithethefatsi ke ho eketsa katleho ea tsona le ho fokotsa kotsi ea litlamorao le li-contraindication. Joalokaha ho ile ha etsahala nakong ea liteko tsa kliniki, sena ha se sebetse bakeng sa li-statins. Likhamphani tsa nts'etsopele ha lia ka tsa fihlela leha e le efe ea lipheo tsena. Ebile mokhoa oa bone, moloko oa ho qetela o ntse o le kotsi ho latela litlamorao tsa bophelo bo botle.

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• ka potlako le ka mokhoa o atlehileng ho fokotsa cholesterol ea mali ka 60%, hobane li thibela ts'ebetso ea li-enzymes (HMG-CoA reductase), tse tlatsetsang ho hlahiseng lipoprotein tse kotsi.
• eketsa bongata ba k'holeseterole e nang le molemo,
• ntlafatsa sebopeho sa mesifa ea pelo, ho thibela bofokoli ba eona,
• mo lumella hore a sebetse ka botlalo,
• imolla khatello ea maikutlo
• fokotsa kotsi ea ischemia ka 15%, angina pectoris le lefu la pelo - ka 25%,
• eketsa tebello ea bophelo.

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• khatello ea kelello ea methapo
• atherosulinosis
• hypercholesterolemia,
• myocardial infarction
• Lefu la pelo ea Ischemic,
• ACS
• thibelo ea ho otloa ke lefu la pelo, ho nyekeloa ke pelo,
• opereishene ea pelo le pelo.

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Leha ho le joalo, joalo ka ha boikoetliso bo bonts'a, ho bohlokoa ho abela li-statin khahlano le atherosulinosis le li-CVD tse ling feela ho batho ba lilemo li bohareng. Bakeng sa batho ba baholo (ka mor'a lilemo tse 60-70), ha ba na thuso ebile ba kotsi ho feta thuso.

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Li -ququitors tsa bile acid

Khoutu ea PBX: C10AC.

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• Colextran (Questran),
• Ho isa Kolesevelam (Colesevelam),
• Cholestipol, Colestipol (Colestipol),
• Cholestyramine, Colestyramin (Colestyramin).

Li na le phello e matla ea pharmacological. Theha litlamo tse matla tsa lik'hemik'hale ka asiti ea bile u li tlose. Mmele o na le khaello e matla ea lintho tse nang le thuso bakeng sa mesebetsi ea eona ea bohlokoa. Pontšo e lumellanang e romeloa ho sebete, e qalang motsoako oa bona o sebetsang. Ho etsa sena, o hloka pokello ea cholesterol e kholo eo a e sebelisang. Kahoo khatello ea eona maling e ea fokotseha.

p, blockquote 45,0,0,0,0 -> Li -ququitors tsa bile acid

Hangata e fumaneha ka mokhoa oa phofo e qhibilihang ka metsing kapa lero.

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Ha li kenngoe maling, ka hona li bolokehile hantle bakeng sa bophelo bo botle. Leha ho le joalo, lingaka tse 'maloa li boetse li li hanyetsa ka lebaka la hore li fokotsa ho kenella ha li-acid acid, tse bohlokoa bakeng sa ts'ebetso ea litho tse ngata le litsamaiso. Sebete ha se kamehla e nang le nako ea ho kopanya palo ea bona e hlokahalang. E boetse e fokotsa ho kenella ha acid ea folic ka mala.

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Ho tlameha ho hopoloa hore boemo ba triglycerides ka ts'ebeliso ea li-sequestrants tsa bile ha bo fokotsehe. Haholo-holo bakeng sa sena, o tlameha ho noa lithethefatsi tse ling ka ho tšoana.

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Litokisetso tse thehiloeng ho Niacin

Khoutu ea PBX: C10AD.

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• Acipimox (Acipimox),
• Aluminium nicotinate (Aluminium nicotinate),
• Niacin (Ac>Niacin

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• fokotsa cholesterol e mpe mme o eketse botle
• activate fibrinolysis,
• fokotsa thrombosis.

Phekolo ke ea nako e telele, le litekanyetso li ntse li eketseha butle-butle. Statins le fibrate li hanyetsanoa ho sebelisa ka mokhoa o ts'oanang le lithethefatsi tse thehiloeng nicotine (motsoako oa tsona o tsosa nts'etsopele ea litla-morao.

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• lefu la tsoekere
• gout
• gastritis
• seso sa ka mpeng.

Hora pele le hora e le 'ngoe ka mor'a ho nka litokisetso tsa acid ea niacin, u ke ke ua noa lino tse tahang. Litla-morao, ho ba le ho hloka botsitso ka mpeng, empa hangata ho etsahala hona moo ho nang le gastritis kapa liso. Hang ka mor'a tšebeliso, hyperemia e matla ea sefahleho e ka qala. Ho kenyelletsa phello ena, aspirin e nkuoa halofo ea hora pele e e nka. Ba bang ba hlokomela mathata a letlalo: ho hlohlona ha letlalo, ponahalo ea liso le erythema.

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Lithethefatsi tse ling tse fokotsang lipid

Khoutu ea PBX: C10AX.

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Ezetimibum (Ezetimibum)

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Mabitso a khoebo: Ezetrol, Ezetimibe, Lipobon, Otrio. Setlhare ke moloko o mocha. Ketso ea eona ea pharmacological e fapana le molao-motheo oa mosebetsi oa lithethefatsi tse ling tse fokotsang lipid.E kenelletse ka mpeng e nyane mme e thibela ho monya cholesterol. Sena se lebisa ho fokotseheng ha ho kenella ha eona ka har'a sebete. Kahoo lipolokelo tsa lipoprotein lia fokotseha, 'me ho felisoa ha tsona maling ho eketseha.

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Contraindication: hypersensitivity, lefu le matla la sebete, ho nyeka, ho ima.

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Litla-morao: lets'ollo, mokhathala, feberu, sinusitis, ts'oaetso ea phepelo ea phepelo ea methapo, arthralgia, bohloko ba mesifa. Ha ho khothalletsoe ho kopantsoe le cyclosporine le lithethefatsi tse ling tse fokotsang lipid.

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Policosanol (Policosanol)

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K'holeseterole ea moloko oa ho qetela e theola lithethefatsi. Kamora liteko tsa tleliniki, e bontšitse ts'ebetso e phahameng esita le ho bapisoa le li-statins. Ka nako e ts'oanang, litla-morao li bonoa hangata, 'me ha li kotsi haholo bophelong. Ha e le tseleng, e fokotsa mohopolo oa alanine aminotransferase le gamma glutamyl transpeptidase. E entsoe motheong oa li-alkoholi tsa aliphatic tse tsoang tsoekere.

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Contraindication: lilemo tse ho fihlela ho 18, moimana, hypersensitivity, lactation.

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Litla-morao: ho nyekeloa ke pelo, lets'ollo.

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Studucol

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Mabitso a Khoebo: Bifenabid, Fenbutol, Lesterol, Lipomal, Superlipid. E na le phello e habeli: e fokotsa sebopeho sa k'holeseterole e bokong le ho kenngoa ha eona maling ho tsoa mala. Ha e ame mokokotlo oa li-triglycerides. Abelana le hypercholesterolemia, tšenyo ea likepe tsa coronary. Contraindication: ventricular arrhythmias, boimana, lebelo. Bakeng sa litla-morao, dyspepsia hangata e hlokomeleha. Bonyane ba Studucol ke hore e fokotsa cholesterol e kotsi le e molemo. Ba bangata hape ha ba rate tlhoko ea kalafo e telele. Phello ea pele e bonahala likhoeli tse peli feela kamora ts'ebeliso ea ts'ebeliso ea eona. Re lokela ho hopola hore sesebelisoa sena se ka sotha liphetho tsa electrocardiogram.

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Omega 3 Polyunsaturated Fatty Acids

p, blockquote 69,0,0,0,0 -> Tlatsetso le mafura a Omega-3 polyunsaturated fatty acids

Mabitso a khoebo a tlatsetso ea phepelo ea lijo: Doppelgerz Omega, Omacor, Oceanol. Hangata li na le oli ea tlhapi. E fokotsa kotsi ea CVD, e fokotsa cholesterol, e u pholose ho sithabetseng, 'me e felise ramatiki. Ka tšebeliso e sa nepahalang kapa e telele haholo, e ka tsosa nts'etsopele ea pancreatitis.

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Dextrotyroxine (Dextrothyroxine)

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E tšoauoa ka ho monya hantle oa mala. E khethoa ha ho hlokahala ho fokotsa khatello ea k'holeseterole e fetang. Ha e le tseleng, e thusa ho etsa tšoelesa ea tšoelesa ea qoqotho. E matlafatsa thepa ea eona ea hypolipidemic hammoho le nicotine le clofibrate. Phekolo e fanoa ka litekanyetso tse nyane tse lateloang ke ho eketseha ha tsona. Litla-morao: mamello ho lik'habohaedreite ea fokotseha, bilirubin ea eketseha, leukopenia e fumanoa.

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Contraindication: Ho nyekeloa ke pelo, lefu le matla la Angina pectoris, lefu la tsoekere.

p, blockquote 73,0,0,1,0 -> Litlhare tse ka kenngoang lijalo tsa Amerika Repatha (Repat) and Praluent (Praful)

Lithethefatsi tse theolang lipid tse bontšitsoeng tlasa khoutu ea C10AX ho ATS le tsona li kenyeletsa:

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• Benfluorex (Benfluorex) - e thibetsoe linaheng tse ngata ka lebaka la chefo ea eona e phahameng,
• Magnesium pyridoxal, coenzyme B6 (Magnesium pyridoxal 5-phosphate glutamate),
• Meglutol (Miglutol),
• Thiadenol (Tiadenol).

Lithethefatsi tse tsoang ente ea Amerika Repatha (Repat) le Praluent (Praitive) li tšepisa ho khutlisa maemo a cholesterol ka liente tse peli feela ka beke. Leha ho le joalo, sechaba sa bongaka ha se potlakele ho ba khothaletsa ho bakuli ba sona, kaha ho sa ntse ho na le liteko tse ngata tsa tliliniki ho netefatsa katleho ea tsona.

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Mefuta e Mefuta-futa ea Lipid

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Lethathamo la mefuta e meng e ka khonehang le e tsebahalang haholo:

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• Atorvastatin + Amlodipine,
• Lovastatin + Nicotine,
• Pravastatin + Aspirin,
• Simvastatin + aspirin,
• Simvastatin + Ezetimibe.

Motsoako o tšoanang oa lithethefatsi o laetsoe ho matlafatsa sephetho sa bona sa ho fokotsa lipid.

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Ha se motho e mong le e mong ea chesehang ka tlhoko ea ho theola cholesterol ka lithethefatsi tse matla tsa maiketsetso. Ka hona, haeba litaba tsa eona li sa phahame haholo, ngaka e ka fana ka litlatsetso tsa tlhaho le thepa e fokotsang lipid. Li sebetsa ka bonolo ebile li na le sebopeho sa tlhaho. Leha ho le joalo, ha u nka qeto ka ts'ebeliso ea bona, u hloka ho ba hlokolosi hore ha se meriana ebile ha ba khone ho felisa mafu a tebileng a amanang le lipoprotein. Ba ka ntlafatsa maemo hanyane feela.

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Bohlokoa Forte N

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Motsoako o kopantsoeng oa hepatoprotective, o kenyelletsang "phospholipids" ea bohlokoa (cholinophosphoric, linoleic le linolenic acid), pyridoxine, cyanocobalamin, nikotine, pantothene, riboflavin, tocopherol. E khothaletsa ho phatloha le ho felisoa ha "cholesterol" e mpe "ho ntlafatsa thepa e ntle ea" e ntle ".

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Tykveol

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Ho na le oli ea peo ea mokopu. Ho bontšoa kalafo ea cholecystitis, atherosulinosis, hepatitis. E na le hepatoprotective, antioxidant, anti-inflammatory le choleretic.

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Guarem

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Litokisetso tsa litlama. E tlosa cholesterol ha e ntse e le ka mpeng, e fokotsa ho monya ha eona maling. Ka nako e ts'oanang, e potlakisa tlhahiso ea li-acid acid, e etsa hore sebete se li hlahise ka matla. E hatella takatso ea lijo, e thusa ho theola boima ba 'mele. E fumaneha ka mokhoa oa li-granules tse qhibilihang ka metsing, lero kapa lebese. E kopantsoe hantle le lithethefatsi tse ling tse fokotsang lipid. Litla-morao: ho ata ha flatulence, ho nyekeloa le pelo, ho se utloane ka mpeng, lets'ollo.

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Lipoic acid

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Ke antioxidant ea nakong e tlang. E hlalositsoe kalafo ea coronary atherosclerosis.

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SizingPren

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E entsoe motheong oa fir. Ke thuso ea ho phekola maloetse a amanang le khatello ea mali ea methapo, methapo. Lowers triglycerides le cholesterol e mpe.

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Li-vithamine

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Li-vithamine tsa sehlopha B li thusa ho fokotsa cholesterol: riboflavin (B2), pyridoxine (B6), folic acid (B9) le cobalamin (B12). Mekhoa e fokotsang ea lipid ea nicotine (B3) e hlalositsoe ka holimo. Lithethefatsi tsena li ka laeloa ka thoko kapa ka kopanelo. Thuso e ntle haholo e ka ba tlatsetso ea vithamine Benzaflavin (e thehiloeng ho riboflavin).

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Lithethefatsi tse fokotsang Cholesterol li lokela ho phekoloa ka hloko e kholo ka lebaka la litlamorao tse ngata tse ka li bakang. Hangata, katleho ea bona molemong oa thibelo le kalafo ea atherosulinosis le li-CVD tse ling li bohlokoa haholo ho feta litlamorao tsa ts'ebeliso ea bona. Ho fokotsa likotsi, u ke ke ua li sebelisa, ntle le taelo ea ngaka, 'me u tlōla litaelo.

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Mefuta ea Meriana

Kajeno, ho na le lithethefatsi tse ngata tse sebelisetsoang k'holeseterole e phahameng. Li fumaneha ka mokhoa oa litafole le likhakeletsi. Ngaka, e nka boemo ba mokuli, e khetha mekhoa e sebetsang ka ho fetisisa ntle le litlamorao tse fokolang.

Meriana e sebelisetsoang k'holeseterole e phahameng maling e arotsoe ka mefuta e 'maloa.

1. Maemo
2. Fibrate.
3. Motsoako o sitisang ho kenngoa ha lipomprotein tse fokolang haholo.
4. Nicotinic acid

Ha ho na lipilisi tse ntle tsa cholesterol, mofuta o mong le o mong oa lithethefatsi ho na le melemo le likotsi.

Libethe li nkoa li atile haholo; li potlakisa cholesterol kapele. Ha li utloise sebete, esita le ho ba le phello e molemo ho eona.Leha ho le joalo, haeba motho a e-na le lefu le matla la sebete, meriana ena e thibetsoe hore e ka sebelisoa, kaha ho ka ba le mathata a tebileng (ho se sebetse hantle ha sebete).

Lethathamo la lipalo tse tummeng:

1. Simvastatin - Zokor, Vasilip.
2. Atorvastatin - Liprimar, Atoris.
3. Rosuvastatin - Crestor, Acorta.

Tse matla ka ho fetisisa ke chelete ea lihlopha tsa Atorvastatin le Rosuvastatin, ho khothalletsoa ho li nooa hang ka bosiu. Ha li na litlamorao, ka hona, li ka fuoa bana le bana.

Phekolo ea boleng bo phahameng e nkoa e sa sebetse. Li ama metabolism ea lipid, haholo-holo methapo ea methapo e phahameng. Lithethefatsi tsena li laetsoe lithupelong. Li-figrate ha li lumelloe ho tsoakoa le li-statins. Ba joalo ka litlhare tsohle li na le litlamorao, ka hona, ha li laetsoe, litšobotsi tsa motho ka mong li nkuoa.

Li-inhibitors tsa chokosterol (IAH) ha li ratoe haholo, o ka reka mofuta o le mong oa lithethefatsi (Ezetrol) ka k'hemisteng. Ho theola k'holeseterole ho fumanoa ka ho emisa ho monya lipids mala. Moriana ha o na litla-morao tse matla, 'me li ka kopanngoa le li-statins.

Nicotinic acid kapa niacin e fana ka phello e ntle. E thibela tlhahiso ea lipids. Leha ho le joalo, acid ea nicotinic e ama acid e mafura feela, ka hona, kamora ho fela ha thuto, ho bonoa microcirculation. Ha e le molao, ka ho ja chelete ena khafetsa, ho ba le phello e fokotsang.

Hape, bakeng sa taolo ea tšilo ea lijo, li-sequins tsa li-acid acid li lokela ho nkuoa. Tse sebetsang ka ho fetisisa ke cholestyramine le colestipol. Li shebahala li bopa li-acid tse ngata ebe li li fetisetsa litsing tse nepahetseng. Ka ho haella ha tsona 'meleng, cholesterol ea eketseha. Leha ho le joalo, li fuoe hangata hanyane, kaha li na le litlamorao tse ngata.

Li-acid tsa polysaturated li eketsa oxidation maling, ka tsela eo li fokotsa maemo a lipid. Ha li na litla-morao, empa phello ea tsona ha e hlahe hanghang, empa kamora nako e telele.

Lisebelisoa tsa tlatsetso li fokotsa li-triglycerides ka har'a sebete le LDL e tlase. Liphetho tsa kalafo li telele, kahoo li fanoa ho ekelletsa ho litlhare tse ka sehloohong. Mohlala, haeba ho na le lijo tse nyane tsa semela lijong tsa motho, joale ho nka li tlatselletso tsa lijo tse thehiloeng ho fiber ho etsa sena.

Tse sebetsang ka ho fetisisa bakeng sa ho theola cholesterol ea mali ke:

1. Omega Forte.
2. Tykveol.
3. Lipoic acid.
4. Mafura a mafura.

Ha u fana ka lipilisi tsa k'holeseterole, haholoholo ela hloko:

• bong le lilemo
• ho ba teng ha maloetse a sa foleng le a pelo,
• mekhoa e mebe le mokhoa oa bophelo.

Kahoo, ho na le lethathamo le pharaletseng la lipilisi tsa cholesterol. Ho bohlokoa ho khetha pheko e nepahetseng, o ela hloko litšobotsi tsohle tsa mokuli, ketsahalong ena, ho fokotseha ho tla ba molemo.

Ke ngaka feela e ka fanang ka litlhare tse nepahetseng le likhothaletso tse ling tse tlamang.

Bakeng sa thibelo, lingaka li eletsa kamora lilemo tse 20 (habeli ho tse leshome) ho etsa tlhahlobo ho bona hore na cholesterol e kae. Kaha ka botsofali ho batho ba tataisang mokhoa o fosahetseng, o khona ho eketseha. Haeba mokuli a le kotsing, joale letšoao le lokela ho beoa leihlo khafetsa, bonyane makhetlo a 1-2 ka selemo.

Lithethefatsi tse ntle haholo tse theolelang k'holeseterole ea mali

Ho na le mekhoa e 'maloa ea ho loantša cholesterol e phahameng. Pele ho tsohle, ka ho latela mokhoa oa ho ja le mekhoa e meng, hammoho le ho sebelisa lithethefatsi tse nang le phello ea hypoglycemic.

Lingaka li khothaletsa hore u se ke oa itlhahisa 'me u fane ka tokelo ea khetho ea lithethefatsi tse nepahetseng ho setsebi se tšoanelehang. Ts'ebeliso ea litlhare tse ling tsa litlhare e ka ba le litlamorao tse 'maloa tse sa rateheng, ka hona, kalafo ea meriana ena e tlameha ho thibeloa.

Lihlopha tsa lithethefatsi

Ka mokhoa o kopaneng oa ho kenyelletsa cholesterol, ngaka pele, e tla fana ka kalafo ea ho ja ea mokuli. Mohato oa bobeli ke ho fana ka meriana. Lithethefatsi tse fokotsang Cholesterol li ka khethoa ka tsela e latelang:

• li-statins
• fibroic asiti
• lithethefatsi tse khothaletsang phello ea choleretic,
• herbal cholesterol e theolang lithethefatsi.

Bakuli ha ba khothalletsoe ho leka ho kopanya lithethefatsi tsena ka botsona le ho hana ho itlama. Ha o kopanya lithethefatsi le seo ho thoeng ke litlolo tsa setso, ho boetse hoa hlokahala tlhahiso ea ngaka e eketsehileng. Litla-morao tsa ho noha meriana li ka holisa butle butle, ka hona, meriana eohle e lokela ho nooa tlasa taolo ea ngaka kamehla. Haeba ho ka ba le mafu a kopaneng, ho boetse ho khothalletsoa ho tsebisa ngaka ka sena. Sena sohle se tla thusa ho qoba mathata a eketsehileng mme se lebise phello e ntle ea kalafo.

Ho amoheloa ha lithethefatsi tsa sehlopha sefe kapa sefe sa meriana ho lokela ho tsamaisana le bophelo bo botle, ho lahla mekhoa e mebe le ho latela ts'ebetso e leka-lekaneng ea 'mele. Ntlha e arohaneng ke phepo e nepahetseng. Ho tsoa lijong o lokela ho tlosoa ts'ebeliso ea li-fried, letsoai le linoko. Lino: jeme e ncha e lumelloa. Hoa hlokahala ho qoba tšebeliso ea metsi a monate a benyang.

Sehlopha sa pele le se ka sehloohong sa lithethefatsi: li-statin. Lithethefatsi tsena li thusa ho hatella sebopeho sa lipoprotein tse tlase le ho fokotsa boemo ba triglycerides maling a mali. Litla-morao tse ka bang teng li ka hlaha ka lebaka la keketseho e matla ea tekanyetso e boletsoeng le ho kopana ha li-statins le lihlopha tse itseng tsa lithethefatsi. Sehlopha sena sa meriana se pharalletse haholo 'me se kenyelletsa mabitso a fetang 70 a khoebo. Lintho tse sebetsang litokisetsong li ka fapana 'me tsa khetholloa ka meloko. Karolo e ka sehloohong ke lintho tse latelang tse sebetsang: atorvastatin, rosurvastatin, simvastatin, lovastatin.

Har'a litla-morao tse ka bang teng ka lebaka la ho sebelisa lithethefatsi tsa sehlopha sa statin, maemo ana a latelang a khetholloa: mathata a methapo ea lijo, a ka hlahisoang ka mokhoa oa ho bata, ho sokela, ho nyekeloa le pelo le ho eketsa, bakuli ba ka tletleba ka likhathatso tsa boroko, ho tsekela le ho opa ha hlooho. Ho ba teng ha litla-morao leha e le life ke lebaka la ho batla keletso ea ngaka ea hau. Nakong e tlang, ho ka 'na ha hlokahala phetoho ea litekanyetso kapa lithethefatsi sebakeng sa eona.

Ka tšebeliso ea nako e telele ea lithethefatsi tsa sehlopha sena, ho lekola kamehla ts'ebetso ea liphio hoa hlokahala. Ho ea ka lithuto tse fapaneng, tšebeliso ea kamehla ea li-statins le eona e eketsa kotsi ea ho ba le lefu la tsoekere.

Lithethefatsi tse fokotsang Cholesterol le tsona li na le litlolo tse 'maloa. Mohlala, ha li khothalletsoe batho ba nang le ts'oaetso e matla ea ts'ebetso e tloaelehileng ea liphio le ka ho se mamellehe ha likarolo tsa moriana.

Bakuli ba ka buisana le ngaka ea bona ka lihlahisoa tse ncha tse sa tsoa hlaha 'marakeng oa meriana. Sena se o lumella ho khetha moriana o sebetsang hantle le o sireletsehileng. Mohlala, lithethefatsi tse thehiloeng ho fluvastatin ke tsa moloko oa morao-rao oa li-statins. Tsena ke lithethefatsi tsa sejoale-joale tse nang le litla-morao tse fokolang le litlamorao tse potlakileng tsa pharmacological. Rak'hemiste sebakeng sa litlama a ka boetse a eletsa mokuli ka lithethefatsi tse ncha tse sebetsang. Leha ho le joalo, ho lokela ho hopoloa hore ho khethoa ha lithethefatsi ho fokotsa k'holeseterole ho lumelloa feela ke ngaka e eang, ho nahanela litšobotsi tsa motho ka mong.

Lipalo li laeloa ka hloko e kholo ho bakuli ba tsofetseng.Sena se bakoa ke taba ea hore tšebeliso ea atorvastatin e ts'oanang e ka kenya letsoho keketseho ea bohloko sebakeng sa mesifa. Hape, palo e kholo ea bakuli ba lihlopha tsa botsofe e hlokometse likhathatso tsa boroko, maemo a sithabetsang le mathata a takatso ea lijo.

Fibroic asiti

Sehlopha sa bobeli se seholo se kenyeletsa lithethefatsi tse theolelang cholesterol ea mali ho tsoa sehlopheng sa li-acroleine tsa fibroic. Sehlopha sena sa lithethefatsi se ka sebelisoa e le tlatsetso ea lithethefatsi tsa sehlopha sa statin. Karolo ea lithethefatsi ea sehlopha sa fibroic acid ke bokhoni ba bona ba ho fokotsa kapele boemo ba triglycerides le lipoprotein tse tlase, hammoho le ho eketsa palo ea lipoprotein tse phahameng tse loantšang cholesterol e mpe. Lits'oaetso tsa li-acids tsa fibroic li ka tlama ho bile li thibela synthetic cholesterol ke 'mele oa motho.

Litsebi li fana ka lipalo-palo tse bonts'ang hore tšebeliso ea matsatsi a 30 ea lithethefatsi tsa sehlopha sa fibroic acid e theola cholesterol e ngata ka 35-40%, triglycerides ka 20%.

Boholo ba lithethefatsi bo hloekisoa ka liphio, ka hona, haeba ho na le tšitiso ea ts'ebetso e tloaelehileng ea litho tsena, ho nka li-acrole tsa fibroic ha ho khothalletsoe. Litla-morao tse ka bang teng ha u sebelisa litlhare ho tsoa ho sehlopha sa li-acyproic acid li amana haholo le tlolo ea ts'ebetso e tloaelehileng ea ts'ebetso ea mpa.

• Joalo ka lipalo-palo, ho sokela, ho nyekeloa le lets'ollo ho khonahala. Sena sohle se ka hloka kalafo e eketsehileng, e nang le matšoao a sebelisa lihlopha tse ling tsa lithethefatsi (mohlala, omeprazole, e sirelletsang lebota la mala).
• Ho feta moo, phello e mpe tsamaisong ea pelo le methapo e lemohuoe - e eketsa kotsi ea venous thromboembolism.
• Kholiso e ka etsahalang ea ho hlaseloa ke lintho tse kulang: redness ea letlalo, ho hlohlona, ​​lekhopho.
• Maemong a mang, bakuli ba tletleba ka hlooho le ho fokotsa libido.

Haeba e 'ngoe ea litla-morao tsena e hlaha, ho khothalletsoa hore bakuli ba khaotse ho sebelisa lithethefatsi ka nakoana' me ba batle likeletso tsa bongaka.

Cholagogue le meriana

Ho theola cholesterol ea mali le lithethefatsi tse nang le phello ea choleretic ho ba le phello e eketsehileng, e ntle ho tloaelehileng ea triglycerides le lipoprotein tse tlaase. Molao-motheo oa ts'ebetso ea lithethefatsi tsa choleretic o bonolo: ba tlama k'holeseterole e ngata ebe butle-butle ba e tlosa 'meleng. Litokisetso tsa sehlopha sena li mamelloa hantle. Litlamorao tse mpe tse ka bang teng maemong a mang, ho na le lintho tse ling tse amang maikutlo le bohloko ka mpeng.

Ho na le lithethefatsi tse khethehileng tse fokotsang ho kenngoa hoa cholesterol ka kotloloho kahara mokokotlo oa mpa. Tsena li kenyelletsa: Xenical, Orlistat, Ezetrol. Lithethefatsi tse joalo e tla ba bathusi ba bohlokoa haeba k'holeseterole e feteletseng e kena 'meleng ka lijo. Litla-morao ha o sebelisa lithethefatsi tsena ha li monate haholo: takatso ea khafetsa ea ho kheloha, e tsamaeang le ho lokolloa ha mafura a mangata, bohloko bo ka mpeng, ho hanoa ke lintho tse ngata. Khahlano le semelo sa ho nka sehlopha sena sa lithethefatsi, ho hlokahala lijo tse thata ka mokhoa o khethehileng kantle le lijo tse mafura.

Mekhoa e meng

Ts'ebeliso ea lipoic acid le li-capsules, tse kenyeletsang likarolo tsa omega-3, omega-6 le omega-9, hammoho le litlhare tse latelang, ke litokisetso tsa litlama bakeng sa ho theola cholesterol:

• Li-capsules tse omisitsoeng tsa konofolo li boetse li sebelisoa e le kalafo e eketsehileng bakeng sa hypercholesterolemia.
• Molemong oa tsona ke lithethefatsi tse kenyelletsang ho ntšitsoeng ha peo ea mokopu. Mohlala, lithethefatsi Tykveol e thusa ho laola metabolism ea lipid le ho fokotsa triglycerides.
• Litokisetso tsa litlama, tse kenyelletsang litlolo tsa fir, hawthorn, linden le phytoelements tse ling li ka sebelisoa kalafong e rarahaneng ea k'holeseterole e phahameng.
• Ts'ebeliso ea linoic acid e thusa ho thibela nts'etsopele ea atherosulinosis, mafu a tsamaiso ea methapo ea pelo 'me, ho le joalo, a laola maemo a cholesterol.

Litokisetso tse thehiloeng ho likarolo tsa litlama li na le litlamorao tse fokolang mme li mamelloa hamolemo ho feta li-statin kapa li-acrole tsa fibroic. Leha ho le joalo, ts'ebetso ea likarolo tsa limela le boemo ba phello ea tsona k'holeseterole e phahameng li tlase haholo ho lik'hemik'hale tsa li-fibrate kapa li-statin. Ka hona, haeba ho hlokahala hore phokotso ea k'holeseterole e potlake, tšebeliso ea likhalase tsa konofolo kapa oli ea tlhapi e ka sebetsa e le phetoho kalafong ea mantlha.

Ts'ebeliso e eketsehileng ea li-vithamine complexes, tse kenyeletsang livithamini tsa B le nicotinic acid, le tsona li sebelisoa ka bongata ntoeng ea ho loantša cholesterol e phahameng. Ts'ebeliso ea livithamini tse theolelang cholesterol maling e u lumella ho laola metabolism ea lipid, mme nicotinic le folic acid e beha maemong a triglycerides.

Litokisetso tsa ho theola cholesterol li sebetsa kapele le ka mokhoa o nepahetseng. Ho latela taelo ea bongaka le litlhahiso tsohle tsa moetsi, kalafo ea lithethefatsi e tla atleha le ka litlamorao tse fokolang tse ka bang teng. Ho sebelisa lithethefatsi tse ling tse kenyang letsoho ho theola cholesterol kapa che ke khetho ea motho ka mong bakeng sa mokuli e mong le e mong. Leha ho le joalo, motho o lokela ho nahana ka taba ea hore litekanyetso tsa cholesterol tse phahameng li sokela nts'etsopele ea mathata a tsamaiso ea methapo ea pelo, e ka lebisang ho otloa, lefu la pelo le atherosclerosis. Boikutlo ba ho ikatisetsa 'mele oa hau ke senotlolo sa bophelo bo bolelele le bophelo bo botle.

Sehlopha sa mantlha sa lithethefatsi

Pele ho tsohle, lithethefatsi tse fokotsang lipid li lokela ho hlokomeloa. Tsena li kenyeletsa:

1. fibrate
2. li-statins
3. anion e fapanyetsana lithethefatsi le lits'oants'o tse fokotsa ho kenngoa ha k'holeseterole ka mpeng,
4. nicotinic acid
5. probucol.

Ho latela mochini oa ts'ebetso, lithethefatsi tsena li ka aroloa likarolo tse 'maloa:

• Lithethefatsi tse thibelang tlhahiso ea k'holeseterole e tlaase (e boetse e bitsoa e mpe): li-statin, fibrate, nicotinic acid, probucol, moholoflavin,
• li-agents tse ka fokotsang ho kenngoa ha cholesterol: li-guar, li-sequestrants tsa bile acid,
• mafura a metabolism ea mafura a eketsang cholesterol e phahameng haholo: lipostabil, lintho tsa bohlokoa.

Li -ququitors tsa bile acid

Moriana ea hore bile bile asiti hangata e bitsoa li-resin tsa phapanyetsano ea anion. Hang ha lithethefatsi tsena li kena ka mpeng, li-acid lia tšoaroa ebe li felisoa 'meleng.

Ba morao-rao ba arabela ts'ebetsong ena ka ho baka tšusumetso ea li-acids tse ncha tse tsoang mabenkeleng a k'holeseterole e seng e le teng. Cholesterol e nkuoa maling, e thusang ho e fokotsa.

Indasteri ea meriana e fana ka meriana ea cholestyramine e phofshoang hammoho le colestipol, ho theola cholesterol ea mali. Li ka sebelisoa ho tekanyetso ea 2-4, ka tlamo ea pele ea tlatsetso ka metsi.

Li-resin tsa phapanyetsano ea anion ha li khone ho kenella maling le "ho sebetsa" feela ka lumen ea mala. Ka lebaka lena, sethethefatsi ha se khone ho ba le phello e mpe 'meleng.

Litlamorao li ka kenyelletsa:

Haeba marang-rang a li-acid acid a sebelisitsoe ka tekanyetso e kholo ka nako e telele, ka nako ena ho ka ba le tlolo ea ho amoheloa ha li-vithamine tse ling, hammoho le bile acid.

Lithethefatsi sehlopheng sena li fokotsa khatello ea seo ho thoeng ke cholesterol e mpe, 'me boteng ba li-triglycerides maling bo lula bo tšoana.

Li-suppressants tsa Cholesterol Absorption

Ka lebaka la ho kenyelletsa k'holeseterole butle butle lijong, sehlopha sena sa lithethefatsi se ka fokotsa khatello ea sona. Tse sebetsang ka ho fetesisa e tla ba katara. Tlatsetso ena ea phepo e sireletsehile ka botlalo 'me e tsoa ho peo ea linaoa tsa hyacinth. Sebopeho sa sehlahisoa se kenyelletsa polysaccharide, eo, ha e kopana le mokelikeli, e fetohang jelly.

Guarem e khona ho tlosa limolek'hule tsa cholesterol marakong a mala. Ntle le moo, sethethefatsi:

• ho potlakisa ho ntšoa ha li-acid acid,
• e hlakola takatso ea lijo
• e thusa ho fokotsa palo ea lijo tse jeoang.

Mohatelli ona oa ho monya o ka sebopeho sa granules ho kenyelletsoa seno. Tšebeliso ea lithethefatsi e ka kopanngoa habonolo le mekhoa e meng.

Nakong ea ts'ebeliso, litla-morao li boetse lia khoneha, ho etsa mohlala, ho theola setuloana, bohloko bo ka mpeng, ho nyekeloa le pelo le ho thunya. Matšoao ana ha a manyane ebile a etsahala ka seoelo. Le ha ho se na phekolo, li feta kapele, ha ho ntse ho e-na le ho fokotseha ho hlophisehileng ha cholesterol ea mali.

Nicotinic Acid

Acid ea Nicotinic le lintho tsohle tse tsoang ho eona, mohlala:

haele hantle, ke livithamini tsa B. Lithethefatsi tsena li fokotsa cholesterol e tlaase le ho kenya tšebetsong sisteme ea fibrinolysis, e thusang ho fokotsa monyetla oa ho thatafala ha thrombosis. Mekhoa e ntlafalitsoeng ho feta lithethefatsi tse ling tse fokotsang lipid e eketsa dikahare tsa k'holeseterole e ntle maling a mokuli.

Kalafo e nang le nicotinic acid e nka nako e telele le keketseho e tlamang ea litekanyetso. Kamora ho etsa litokisetso, pele ho moo ha ua lokela ho noa lino tse chesang, haholo kofi ea tlhaho.

Niacin e ka khopisa mabota a mpa, e sa kenyeng ts'ebeliso ea eona maemong a ulcers le gastritis. Ho palo e kholo ea bakuli, bofubelu ba sefahleho bo ka bonoa qalong ea phekolo, leha ho le joalo, letšoao lena le nyamela ha nako e ntse e tsamaea. Ho thibela bofubelu, o hloka ho nwa halofo ea 325 mg ea halofo ea hora pele u sebelisa lithethefatsi.

Lintho tse ka sehloohong tse khahlanong le nicotinic acid li kenyelletsa:

• hepatitis e sa foleng
• gout
• morethetho oa pelo.

Ho na le moriana o ka bakang litlamorao tse fokolang mme o nka nako e telele ho feta - ena ke enduracin.

Studucol ha e ame triglycerides, empa e boetse e lokisa tekanyo ea k'holeseterole e ntle le e mpe maling. Matlapa a thibelang ho fokola ha mafura 'me a bonts'a tšebeliso ea anti-atherosulinotic, e amang ho fokotseha ha cholesterol ea mali.

Phello ea kalafo e nang le Probucol e ka fumanoa kamora likhoeli tse peli mme e ka nka likhoeli tse 6 kamora ho khaotsa ho e sebelisa. Sesebelisoa se ka kopantsoe ka mokhoa o phethahetseng le lithethefatsi tse ling tse fokotsang k'holeseterole.

Nakong ea kalafo, ho eketsoa ha nako ea sekhahla sa pelo le nts'etsopele ea likotsi tsa morethetho oa pelo. Ho thibela boemo bona, ho hlokahala hore ho be le electrocardiogram bonyane nako e le 'ngoe ho likhoeli tse 6.

Probucol e ke ke ea laeloa ka nako e ts'oanang le cordarone.

Litla-morao tsa 'mele li kenyelletsa bohloko bo ka mpeng ea mpa, ho nyekeloa le pelo le lets'ollo.

Lithethefatsi ha lia lokela ho nkuoa le:

• ventricular arrhythmias,
• khafetsa likarolo tsa myocardial ischemia,
• maemo a tlase a HDL.

Li-figrate li ka khona ho sebetsana ka katleho le boemo ba li-triglycerides, hammoho le khatello ea LDL le VLDL. Li ka sebelisoa ka hypertriglyceridemia ea bohlokoa. Tse tummeng ka ho fetisisa li ka bitsoa lipilisi tse joalo:

• gemfibrozil (lopid, gevilon),
• fenofibrate (Tipantil 200 M, Tricor, Exlip),
• cyprofibrate (lipanor),
• choline fenofibrate (trilipix).

Litlamorao tse mpe tse bakoang ke ts'ebeliso li ka hlahisoa ke bohloko bo ka har'a mesifa, ho nyekeloa le pelo le bohloko bo ka mpeng ea mpa. Fibrate e ka eketsa ho hlaha ha majoe a liphio le lefu la nyooko. Nako e lekaneng, thibelo ea hematopoiesis e ka bonoa.

Lithethefatsi tsena li ka se fuoe mafu a liphio, lefu la nyooko le mathata a mali.

Statins ke lipilisi tse thelisang cholesterol tse sebetsang ka ho fetisisa. Ba khona ho thibela enzyme e khethehileng e arabelang tlhahiso ea ntho e kang mafura sebete, ha e ntse e fokotsa khatello ea mali maling. Ka nako e ts'oanang, palo ea li-receptor tsa LDL e ntse e eketseha, e leng se fanang ka tšusumetso ho koleche e potlakileng ea k'holeseterole e tlaase haholo.

E le molao, litlhare tse latelang li laetsoe:

• simvastatin (vasilip, chakor, aries, simvageksal, simvakard, simvakor, simvastatin, simvastol, simvor, simlo, sincard, holvasim),
• lovastatin (cardiostatin, choletar),
• pravastatin
• atorvastatin (anvistat, atocor, atomax, ator, atorvox, atoris, vazator, lipoford, lypimar, liptonorm, novostat, torvazin, torvakard, tulip),
• rosuvastatin (akorta, sefapano, mertenil, rosartark, rosucard, rosulip, roxera, rustor, tevastor),
• pitavastatin (livazo),
• fluvastatin (leskol).

Simvastatin, hammoho le lovastatin, li entsoe ka fungus. Lithethefatsi tse tšoanang tsa litafole tsa cholesterol e phahameng li fetoha metabolites e sebetsang. Pravastatin ke mofuta oa fungal o tsoang ka boeona e leng ntho e sebetsang.

Statins e ka khothaletsoa hang bosiu bo bong le bo bong. Mokhoa ona oa phekolo o hlalosoa ke taba ea hore tlhoro ea cholesterol ea mali e hlaha bosiu. Ha nako e ntse e ea, tekanyetso ea li-statins e ka eketsoa, ​​'me ts'ebetso ea eona e tla fumaneha kamora matsatsi a' maloa a pele a tsamaiso, e fihla ka bongata ka nako e fetang khoeli.

Lipalo li sireletsehile ka ho lekaneng bakeng sa batho, empa ho bohlokoa haholo hore u se ke ua sebelisa litekanyetso tse kholo, haholo-holo ka li-fibrate, tse nang le mathata a sebete.

Bakuli ba bang ba ka ba le bofokoli ba mesifa le bohloko ba 'mele. Maemong a mang, bohloko ba ka mpeng, ho sokela, ho nyekeloa le pelo, hammoho le ho lahleheloa ke takatso ea lijo, ho hlobaela le hlooho li bohloko.

Lithethefatsi tsena tsa ho fokotsa cholesterol ha li khone ho ama carbohydrate le metaboline ea purine, e li lumellang hore li sebelisoe bakeng sa li-degree tse fapaneng tsa botenya, gout le lefu la tsoekere. Hlokomela hore haeba cholesterol e phahameng e bonoa nakong ea kemaro, ho hlokahala hore o buisane le ngaka ka meriana.

Haeba re nka mofuta oa kalafo ea kalafo ea kalafo, joale li-statins li ka hokahana le kalafo ea atherosclerosis e le monotherapy kapa hammoho le lithethefatsi tse ling.

Pharmacology e fana ka metsoako e itokiselitseng e thehiloeng ho:

1. lovastatin le nicotinic acid,
2. ezetimibe le simvastatin,
3. pravastatin le fenofibrate,
4. rosuvastatin le ezetimibe.

Ho ka lokolloa mefuta e fapaneng ea li-statins le acetylsalicylic acid, atorvastatin le amlodipine.

Ts'ebeliso ea lithethefatsi tse entsoeng ka mokhoa o lokiselitsoeng ha e na phaello e ngata feela ho latela chelete, empa e baka le litlamorao tse fokolang.

Ke life tse ntle le tse theko e tlase?

Litabeng tsa ho boloka bophelo bo botle kapa ho pholosa bophelo, litšenyehelo tsa mori ha ea lokela ho ba tsona feela mokhoa oa khetho, le ha lipilisi tsa cholesterol tse theko e tlase li ka ba ntle haholo. Tsohle li itšetleha ka ho angoa habonolo ha 'mele ho metsoako e sebetsang ea matlapa le tekanyo ea tšenyo ea litho tsa' mele ke hypercholesterolemia (cholesterol e phahameng). Kajeno, kalafong ea boemo bona, boholo ba mefuta e 2 ea lihlopha tsa lithethefatsi e sebelisoa:

• statins (HMG-CoA reductase inhibitors),
• li-fibrate (tse tsoang ho fibroic acid).

Sehlopheng sa li-statins, ho sebelisoa matlapa a cholesterol:

• atorvastatin,
• lovastatin
• pitavastatin
• pravastatin
• rosuvastatin,
• simvastatin
• fluvastatin.

Sehlopha sa fibrate se emeloa ke lintho tse sebetsang:

• bezafibrat,
• tlatsa
• choline fenofibrate,
• koprofibrate.

Har'a litlhare tsa lihlopha tsena, u ka khetha lipilisi tse theko e tlaase tsa k'holeseterole. Mabitso a khoebo a meriana a ka fapana ho tloha mokelikeng (ntho e sebetsang), ka hona ho molemo ho beha khetho ea meriana ho ngaka.

Lithethefatsi tse tsebahalang haholo

Lethathamo la mabitso a lithethefatsi tse ntle ka ho fetisisa

Ha motho a leka ho fumana lethathamo la mabitso a lithethefatsi tse ntle haholo, ha a lokela ho ea k'hemisteng, empa ho ea tleliniking 'me a etsa bonnete ba hore o hloka lipilisi tsa cholesterol e le kannete.

Tse ntle ka ho fetisisa hangata li kenyelletsa meriana e etselitsoeng ho nahanela mefokolo eohle ea meriana e fetileng e hlahileng ho tsa bongaka. Re bua ka meriana ea morao-rao eo ho thoeng ke meloko ea ho qetela, e har'a li-statins, le sehlopheng sa li-fibrate, le lithethefatsi tse ling. Ehlile, theko ea lithethefatsi tsena e phahame haholo ho feta litšenyehelo tsa matlapa a "cholesterol" a tloaelehileng. Re hlahisa lethathamo la lithethefatsi tse theohileng ka ho fetisisa (tse theko e phahameng) tsa lipid tafoleng.

Lipalo-palo tsa ho theola LDL maling

Joalokaha ho ka bonoa tafoleng, li-statin li emela sehlopha se seholo sa lithethefatsi ho theola cholesterol ea mali. Le ha sehlopha sena sa meriana se ntse se sa bake tshepo e felletseng ho bakuli kapa lingaka ka lebaka la lipontšo tse fapaneng khafetsa nakong ea kalafo. Litaelo tsa lipilisi tsena li na le lethathamo la "kilometer" la likotsi, litemoso le likotsi tse ka bang teng ha o nka. Ke ka lebaka leo ho leng bohlokoa hore u ithute lithethefatsi tsena tse fokolisang lipid ka botlalo.

E le hore babali ba utloisise boholo ba tsoelo-pele ea pharmacological ntlheng ena, re bua ka lipalo tse latelang:

• sehlopheng sa li-statins ho na le lintho tse 7 tse sebetsang (mabitso a bona a hlahisitsoe ka holimo),
• ho na le matšoao a 88 a lithethefatsi tsa statin,
• sechaba sa meriana eohle ea sehlopha sena sa bahlahisi ba fapaneng ke mabitso a fetang 3 500.

Ho hlakile hore ho ke ke ha khoneha ho thathamisa mabitso ohle, kahoo re tla shebana le ba tummeng haholo.

Atorvastatin

M kalafo ea ho theola cholesterol Atorvasatin e fumaneha ho tsoa ho baetsi ba bangata linaheng tse fapaneng. Sesebelisoa se sebetsang ke calcium ea atorvastatin, eo e leng ea sehlopha sa pharmacotherapeutic ea lithethefatsi tse fokotsang lipid tse fokotsang, inhibitors tse khethiloeng tsa HMG-CoA reductase. Phello ea eona ke ho fokotsa boemo ba lipoprotein tse tlaase le tse tlase haholo (LDL le VLDL), triglycerides le apolipoprotein B ka ho thibela ho hlophisoa ha k'holeseterole maling. Ho feta moo, tlasa ts'usumetso ea atorvastatin, boemo ba HDL - lipoprotein tse phahameng haholo li eketseha hanyane ka hanyane.

Sehlopha sa lik'hamphani tsa meriana KRKA le makala a sona ba hlahisa matlapa a k'holeseterole Atoris e nang le ntho e sebetsang ea atorvastatin. Joalo ka li-statins tse ngata, li na le bokhoni bo netefalitsoeng ba ho fokotsa kotsi ea mathata a kang angina pectoris le lefu la pelo (26 le 16%, ka ho latellana). Li thibela ts'ebetso ea li-macrophage, li thibela ho phatloha hoa li-plaque tsa atherosselotic.

E lumellane le maemo a tloaelehileng a li-statins:

• le mafu a sebete le keketseho ea li-transaminases makhetlo a fetang a 3 ho tsoa monyako o kaholimo oa tloaelo,
• khaello ea lactase le maemo a mang a amanang le ho hloka mamello ho lactose,
• ka marapo a mesifa
• ho ima le ho nyekeloa,
• ka tlase ho lilemo tse 18.

Matlapa a fumaneha ka litekanyetso tsa 30, 60 le 80 mg. Ponahalo - lipilisi tse tšoeu tsa convex tsa sebopeho se chitja kapa sa oval.

Ho fokotsa khatello ea cholesterol le ho fokotsa kotsi ea mathata a pelo, ho latela litaelo tsa ts'ebeliso, lithethefatsi tsa Novostat le tsona li reretsoe (ka kopo hlokomela - eseng Novostatin). Ka linako tse ling baeti ba rekisang meriana (haholo-holo ba batlang lipilisi tsa ho theola cholesterol ho latela tlhahlobo ea metsoalle) ba ferekanya lebitso la moriana ona le moriana o mong 'me ba ba kope hore ba ba fe myostical Novostatin. Bakuli ba joalo ba sa tsotelleng ha baa lokela ho makala haeba, sebakeng sa moemeli ea fokotsang lipid, ba fuoa Nystatin ea antifungal.

Novostat e thehiloe ho atorvastatin mme e na le thepa eohle ea pharmacodynamic ea ntho ena e sebetsang.

Khamphani ea Czech Zentiva e etsa matlapa a k'holeseterole ea atorvastatin e thehiloeng ka har'a torvacard. Joalo ka lithethefatsi tsohle tse nang le motsoako ona o sebetsang, litaelo tsa tšebeliso ke tsa boholo bo tsotehang, tse bonts'ang tlhokeho ea ts'ebeliso e hlokolosi le e laoloang ea Torvacard. Litlamorao tse atileng haholo - hyperglycemia, dyspepsia, flatulence, ho hlatsa, ho sokela, ho nyekeloa, ho se sebetse ha sebete, ho opeloa ke hlooho, ho hlekefetsoa ke lintho tse ling - ke mofuta oa lithethefatsi tse ngata tsa statin.

Rosuvastatin

Matlapa a nang le ntho e le 'ngoe e sebetsang ke lipilisi tsa pinki tse sebopeho se chitja. Mochine oa ts'ebetso ea rosuvastatin o ts'oana le pharmacodynamics ea li-statin tsohle, ntho ena ke ea subtype ea tlholisano, e thibelang li-inhibitors tsa HMG-CoA reductase. Ba abetsoe:

• le hypercholesterolemia ea mantlha, e tsoakiloeng le e futsitsoeng,
• hypertriglyceridemia,
• ho theola cholesterol ho atherosulinosis e le ho thibela tsoelo-pele ea eona.

Rosuvastatin e sebetsa hantle ho thibelo ea CVD le mathata a ho bakuli ba nang le mabaka a kotsi - khatello ea methapo ea mali, boemo bo potlakileng ba lelapa ho lefu la methapo ea methapo, lekhoba la nicotine.

Kalsiamo ea Rosuvastatin ke karolo e sebetsang ea matlapa a Roxer a entsoeng ke Krka. Tsena ke lipilisi tsa “white” tse tšoeu tse nang le "5" ka lehlakoreng le le leng. Ka sebopeho sa li-excipients, joalo ka matlapeng a ka holimo a k'holeseterole, ho na le lactose, joalo ka bakuli ba nang le tsoekere ea lebese kapa ba haelloang ke lactase ba lokela ho tseba ka.

Rosart hypolipidemic agent ke ea sehlopha sa litafole tsa cholesterol tse theko e tlase li thehiloe ho rosuvastatin. E fumaneha ka mefuta e mene ea litekanyetso:

• 5 mg - pilisi e potolohileng e bosoeu bo khokhothetsoeng ka "ST1" "ka lehlakoreng le leng,
• 10 mg - matlapa a pinki, a chitja a tšoailoeng "ST2",
• 20 mg - lipilisi tse pinki tse pota-potileng, tse ngotsoeng "ST3",
• 40 mg - matlapa a na le sebopeho sa oval mme a ngola "ST4".

Matlapa a Krestor a hlahisoa ke makala a fapaneng a k'hamphani ea Borithane ea Astra Zeneca mme ke "statin" e ithutoang haholo ho latela rosuvastatin. Ka lebaka lena, li boetse li nkuoa e le sethethefatsi se itlhommeng pele (eseng se theko e tlase) sehlopheng sa lithethefatsi tse fokotsang lipid. Ho bonolo ho khetholla matlapa a mantlha ka ho koahela "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" ZD45225 "e ne e le lehlakoreng le le leng.

Statin Rosucard e entsoeng ka Czech (motsoako o sebetsang o hakantsoe ka lebitso) e fumaneha ka mefuta e meraro ea litekanyetso:

• 10 mg - likhalase tse khanyang tsa pinki tse bobebe tse tsoang khetla ea polymer,
• 20 mg - e tšoana hantle le e fetileng, empa 'mala oa khetla o fapaneng.
• 40 mg ke lipilisi tse pinki tse lefifi.

Rosucard e boetse e bua ka lipilisi tse theko e phahameng, leha lenane la likarabelo tse mpe le litemoso tsa ts'ebeliso ea lona le sa khuts'oane ho feta tsa li-statins tse ling. Haeba u sebelisa sethethefatsi sena ka mokhoa oo u laetsoeng le ka tlasa tlhokomelo ea ngaka, kotsi ea mathata a fokola.

Lithethefatsi tse ling tse phahameng tsa cholesterol

Haeba, kamora ho kopana le li-statins, takatso ea ho phekoloa le bona e fokotsehile (mme bakuli ba bangata ba tšaba ho ba nka), ho bohlokoa ho ela hloko meriana e meng e theolang cholesterol. Tsena ke lithethefatsi tsa sehlopha sa fibrate - derivatives ea fibroic acid, e ntlafatsang lipolysis le ho tlosa seo ho thoeng ke atherogenic lipoproteins (LDL le VLDL) maling, hammoho le ho fokotsa khatello ea mali (triglycerides). Lipilisi tsena tsa cholesterol ha li theko e tlase, empa u ka khetha li-analogues tsa tlhahiso ea Maturkey (mohlala, Lipofen), tse theko e tlase habeli ho feta lipilisi tsa Mafora.

Ntle le li-fibrate le li-statins, kalafo e fokotsang lipid e sebelisa inhibitors ea k'holeseterole e nang le ntho e sebetsang ea ezetimibe (Ezetrol), eo ka khetho e thibelang (thibela) ho kenngoa ha cholesterol e tsoang semeleng le li-sterols ka mala.

Ke eng e betere eo nka e noang?

Seo u ka khethang ho sona lethathamong la meriana e joalo e hanyetsang, eo ho leng molemo ho e sebelisa? Statins le fibrate li tšosa ka litlamorao tsa tsona ho sebete le mesifa ea marapo, lithethefatsi tsa morao-rao li theko e phahameng haholo. Lingaka li khothaletsa hore leha ho le joalo u qale ka ho ja li-statin ka hloko le ka mokhoa o laoloang mme, haeba ho ka etsahala hore li sebetsa hantle ebile li mamelletse hantle, u ka fumana kalafo e felletseng.

Haeba li-statins kapa li-fiber ha li tšoanelehe, ho na le matlapa a mang a tsoang lihlopheng tsa li-inhibitors tsa cholesterol kapa li-agents tse kopaneng tse thehiloeng ho tsona.

Ka nako e 'ngoe u ka utloa hore matlafatso a bioactive (BAA) Energy a ka sebelisoa e le matlapa a cholesterol. Empa ho latela litaelo tsa ts'ebeliso, lihlahisoa tse nang le lebitso la khoebo la Energia ke li-vitamini le li-mineral complexes tse etselitsoeng batho ba haelloang ke likarolo tse itseng tsa mohlala. Taba ea hore Energy ke litafole tsa cholesterol ha e boleloe ho Annotation. Ka tloaelo lithethefatsi ha se moriana, ebile ha li khothalletse metabolism, ka hona, ha ho bohlale ho e fa karolo ea moemeli ea fokotsang lipid.

Bakuli ba kanna ba ferekanya Energy le moemeli ea kopaneng ea lipid ea kopantsoeng ea Setaliana kapa ea Singapore e thehiloeng simvastatin le ezetimibe (statin le cholesterol inorpitor). Ena ke pheko e ntle ea hypercholesterolemia.

Hoa hlokahala ho bua ka lipilisi tsa Alisat (kapa feela "Garlic"), tseo ba bangata ba li nkang e le lipilisi tsa cholesterol. Tlatsetso ena ea lijo e etselitsoe ho tlatsa 'mele ka bofokoli ba allicin, ntho e nang le lihlahisoa tse nang le antifungal le bactericidal.

Haeba u hlile u batla ho phekoloa eseng ka lipilisi tsa cholesterol, empa ka lijo tse tlatsetsang, u ka ela hloko li-capsule tsa Aterolex tse thusang ho ntlafatsa metabolism ea lipid, ho hokahanya ts'ebeliso ea bona le ngaka.

Tse theko e tlase ke life?

Haeba u khetha meriana ho theola cholesterol ea mali sehlopheng se theko e tlaase, u lokela ho e batla har'a lithethefatsi tsa sehlopha sa statin:

• Atorvastatin (e nang le ntho e tšoanang e sebetsang),
• Cardiostatin (lovastatin),
• Reddistatin (rosuvastatin),
• Vasilip (simvastatin).

Kajeno, ana ke meriana e theko e tlaase ea cholesterol e phahameng ea mali.

Ka litlamorao tse fokolang

Morero oa mantlha oa ho kopanya lithethefatsi tse ncha ke ho fokotsa palo ea litlamorao ha o ntse o boloka ts'ebeliso e phahameng ea lithethefatsi. Ka hona, matlapa a tsoang ho cholesterol ea moloko o mocha - li-inhibitors tsa ho monya k'holeseterole ka popelong (Ezetrol) - li nkoa e le lithethefatsi tse sireletsehileng ka ho fetisisa tsa ho fokotsa lipid. Sena ha se bolele hore lithethefatsi tsena ha li na litla-morao mme lenane la tsona le leholo haholo. Empa ho latela litaelo tse sebelisoang, lipontšo tsena tse sa rateheng li bonoa ka mekhahlelo e “sa lekanyetsoang” le “ka seoelo”, e buang molemong oa polokeho.

Na hoa khoneha ho fokotsa kapele le ka nepo?

Ho thata ho motho ea sa tloaeloang ho mamela maemo ho amohela tlhokahalo ea ho sebelisa meriana nako e telele le ho latela lijo. Bakuli ba joalo ha ba felloe ke mamello ebile ba batla lipilisi tse fokotsang cholesterol kapele le ka tsela e nepahetseng. 'Me litheolelo tse joalo ha li na ho ba teng, kaha ho khutlisoa ha metabolism ea mafura e hlokahalang ho tsitsisa maemo a cholesterol maling ke ts'ebetso e telele, e butle-butle. Ho ke ke ha khoneha ho phekola lefu la ramatiki le litafole tse 'maloa, tseo ka linako tse ling li bileng teng ka lilemo. Ka hona, bakuli ba nang le hypercholesterolemia ba lokela ho itokisetsa phekolo ea nako e telele le liphetoho tse tebileng mokhoeng oa bophelo.

Tlhahlobo ka kakaretso

Tlhahlobo ea mamello ea lintho tse fapa-fapaneng tse sebetsang tsa lithethefatsi tse fokotsang lipid lia khahlisa, ho u lumella ho utloisisa hore na ke life tsa tsona tse mamelloang hamolemohali, tse sebetsang haholoanyane.

Ho latela liphuputso tse entsoeng ke mokuli, boholo ba bona ba phekoloa ka li-statins tse ba abetsoeng tleliniking. Ho tsoa sehlopheng sena sa lithethefatsi, matlapa a k'holeseterole ea atorvastatin le rosuvastatin a fumane litlhahlobo tse ntle. Ka tsela, rosuvastatin e bitsoa e ntle ka ho fetisisa, hobane nakong ea tsamaiso ea eona bakuli ba bangata ha baa ka ba e-ba le karabelo e mpe.

Har'a li-fibrate, Tricor o fumane litlhahlobo tse ntle.

Ezetrol o bitsoa pilisi e ntle ka ho fetisisa ea k'holeseterole, empa lingaka le bakuli ba hlokometse hore ke "moriana o theko e boima haholo."

U ka fokotsa cholesterol joang ntle le lithethefatsi?

Ka lebaka la likotsi le litšenyehelo tsa kalafo tsa lichelete, bakuli ba bangata ba batla ho fumana mofuta o mong ntle le lithethefatsi kalafo e fokotsang lipid. Mekhoa e joalo e teng, leha e hloka cheseho e khethehileng, taeo le mamello, hobane mekhoa ena e ke ke ea fana ka phello e potlakileng. Ke potso ea ho felisa lintho tse joalo tse tsosang tsa ho ferekana ha lipid metabolism joalo ka ho ikoetlisa 'meleng, litloaelo tse mpe le khaello ea phepo e nepahetseng.

Mehato e rarahaneng ea mehato eo e seng ea lithethefatsi e lokela ho kenyelletsa mokhatlo oa mofuta oa letsatsi ka phomolo e nepahetseng le ho fokotsa khatello ea maikutlo.

Ha u felisitse phepelo ea lihlahisoa tse kotsi, o ka theola ts'ebetso ea hau ea tšilo ea lijo ka tlhoko ea ho monya mafura le li-saccharides tse tla ama profil ea hau ea lipid. 'Me ho tsitsisa maemo a cholesterol maling, hoa hlokahala ho boloka mokhoa o khethehileng oa ho fokotsa lijo o fanang ka metabolism.

Mokhoa oa bophelo o mafolofolo

Ho ikoetlisa ka ho sa lekaneng ho lebisa ho tsitsinyeheng ha mali le ho emisoa hoa matla a sa sebetseng ka mokhoa oa mafura a mangata 'meleng. Li kentsoe hoo e batlang e le litho tsohle tsa bohlokoa, li sitisa tšebetso ea tsona e tloaelehileng le ho sitisa metabolism ea mafura a tlhaho. Ho fetola mokhoa oa bophelo mabapi le ho eketsa ts'ebetso ea 'mele ho thusa ho ntlafatsa phallo ea mali le ho etsa hore lits'ebetso tsohle li kenyeletse metabolism ea mafura. Ke ka hona ho leng bohlokoa haholo ho kopanela kamehla lithutong tsa boikoetliso - li-gymnastics tsa hoseng ho hong le ho hong, ho matha, ho tsamaea, ho sesa makhetlo a 'maloa ka beke, ho ikoetlisa kamehla mosebetsing.

Lijana tse hloekisang tse nang le litlhare tsa setso

Litlhare tsa Folk le tsona li fumane sebaka kalafong e fokotsang lipid. Tlhaho e na le limela tse ngata tse tlatsetsang ho ntlafatseng ha metabolism le ho phatloha ha mafura. Maruo ana a theha motheo oa litlolo tsa lithethefatsi tse hloekisang methapo ea mali le cholesterol e tlase. Ha o qala kalafo ka litlhare tsa setso, ho lokela ho hopoloa hore kalafo ea litlama ke mosebetsi o mongata, hape ba ka ba le litlamorao le li-contraindication bakeng sa tšebeliso.