Litlhahlobo tsa Rosucard

Sesebelisoa se ka sehloohong sa Rosucard ke rosuvastatin. Haholo-holo phello ea lithethefatsi e hlaha ka har'a sebete - setho sa mantlha bakeng sa motsoako oa k'holeseterole. Rosucard e theola boemo ba lipoproteins tse tlase (LDL), ke hore, "mpe" cholesterol mme e eketsa boemo ba "cholesterol" e ntle "(HDL - lipidrotein tse phahameng).

Beke kamora ho qala ho nka Rosucard, ts'ebetso ea eona e ntle ea kalafo e hlokomeleha. Pholiso e phahameng e ka fihlella libeke tse peli kamora ho qala kalafo le Rosucard. Ho fihlela phello e tsitsitseng, tsela ea kalafo e lokela ho lula bonyane khoeli e le 'ngoe.

Matšoao a sebelisang Rosucard ke:

• hypercholesterolemia ea mantlha,
• dyslipidemia e tsoakiloeng,
• hereditary hypercholisterinemia,
• atherosulinosis.

Hape, moriana o laetsoe ho thibela nts'etsopele ea mafu a pelo le bakuli ba kotsing.

Karolo ea ts'ebeliso ea Rosucard ke hore pele a qala ho sebelisa moriana, mokuli o lokela ho qala ho latela lijo tse nang le khalori e tlase le ho li latela nakong eohle ea kalafo. Ho latela litaelo, Rosucard e ka nkuoa ka nako efe kapa efe ea letsatsi, ho sa tsotelehe lijo tseo motho a li jang.

Tekanyo ea lithethefatsi e khethoa ke ngaka ka bonngoe, ho nahanoa ka sepheo le karabelo ea mokuli. Maemong a mangata, lethal dose la Rosucard ke 10 mg. Kamora khoeli, e ka eketsoa ho 20 mg. Maemong a thata haholo, ho fanoa ka 40 mg ea Rosucard. Setlhare sena se kopantsoe ho bana ba ka tlase ho lilemo tse 10.

Ts'ebetsong ea ho nka Rosucard, ho ka lemohuoa litla-morao tse ling. Kahoo khahlano le boemo ba mokokotlo oa mokokotlo le ho opeloa ke hlooho, khaello ea maikutlo ho tsoa mokhoeng oa ka mpeng, e leng bohloko ba ka mpeng, ho nyekeloa le pelo, ho nyekeloa, dermatitis ea allergic. Ho sa tloaelehang haholo mathata a ho robala, hammoho le ts'ebetso ea ho ruruha ho sebete - hepatitis. Litla-morao tsa Rosucard, joalo ka molao, li itšetlehile ka litekanyetso.

Contraindranation mabapi le ho nka Rosucard ke:

• motho ka mong,
• mafu a fapa-fapaneng a sebete, ho kenyelletsa le maemo a eketsehang a transaminase,
• lefu la liphio
• cyclosporine,
• ho ima le ho nyekeloa,
• myopathies.

Ka tlhokomelo e khethehileng, Rosucard e laeloa bakuli ba morabe oa Asia kapa ba baholo ho feta lilemo tse 70, hammoho le hypothyroidism, botahoa, kalafo ka fibrate le ka mor'a mafu a mesifa. Ha u nka Rosucard, batho ba nang le tsoekere e phahameng ea mali ba kotsing ea ho ba le lefu la tsoekere.

Ka mekhahlelo ena ea bakuli, pele u fana ka Rosucard, ho bohlokoa ho bapisa likotsi tse teng le phello e boletsoeng esale pele ea kalafo. Ha u ba fa moriana oa bongaka, ho khothalletsoa kalafo hore e etsoe sepetlele tlasa tlhokomelo ea bongaka e tsoelang pele.

Pele o qala ho ea kalafo le Rosucard, bakuli ba lemosoa ka tlhoko ea ho tsebisa ngaka e hlahang ka ponahalo ea bohloko ba mesifa, mokoka, bofokoli, haholoholo ka malaise e akaretsang le hyperthermia. Qeto ea ho hlakola kapa ho tsoella ho nka moriana e etsoa motheong oa data ea laboratori.

Li-analog tsa Rosucard

Match ho ea ka lipontšo

Theko e tsoa ho li-ruble tse 54. Analogue e theko e tlaase ka li-ruble tse 811

Match ho ea ka lipontšo

Theko e tsoang ho li-ruble tse 324. Analogue e theko e tlaase ka li-ruble tse 541

Match ho ea ka lipontšo

Theko e tsoa ho li-ruble tse 345. Analogue e theko e tlaase ka li-ruble tse 520

Match ho ea ka lipontšo

Theko e tsoa ho li-ruble tse 369. Analogue e theko e tlaase ka li-ruble tse 496

Match ho ea ka lipontšo

Theko e tsoa ho li-ruble tse 418. Analogue e theko e tlase ka li-ruble tse 447

Match ho ea ka lipontšo

Theko e tsoa ho li-ruble tse 438. Analogue e theko e tlase ka li-ruble tse 427

Match ho ea ka lipontšo

Theko e tsoa ho li-ruble tse 604. Analogue e theko e tlaase ka li-ruble tse 261

Match ho ea ka lipontšo

Theko e tsoa ho li-ruble tse 660. Analogue e theko e tlaase ka li-ruble tse 205

Match ho ea ka lipontšo

Theko e tsoang ho li-ruble tse 737. Analogue e theko e tlaase ka li-ruble tse 128

Fomu ea tokollo, sebopeho le sephutheloana

Matlapa a koahetsoeng ka filimi pinki e bonolo, oblong, biconvex, e nang le kotsi.

1 tab
khalsiamo ea rosuvastatin	10,4 mg
e tsamaellanang le litaba tsa rosuvastatin	10 mg

Baeti: lactose monohydrate - 60 mg, selulose ea microcrystalline - 45,4 mg, croscarmellose sodium - 1,2 mg, colloidal silicon diode - 600 μg, magnesium stearate - 2.4 mg.

Sebopeho sa khetla ea filimi: hypromellose 2910/5 - 2,5 mg, macrogol 6000 - 400 μg, titanium diamusi - 325 μg, talc - 475 μg, dae e khubelu oxide - 13 μg.

Li-pcs tse 10 - lithutsoana (3) - lipakete tsa karete.
Li-pcs tse 10 - lithutsoana (6) - lipakete tsa karete.
Li-pcs tse 10 - marangrang (9) - lipakete tsa karete.

Ketso ea pharmacological

Hypolipidemic lithethefatsi ho tsoa sehlopheng sa li-statins. Inhibitor e khethiloeng ea HMG-CoA reductase, enzyme e fetolang HMG-CoA ho mevalonate, moetapele oa k'holeseterole (Ch).

E eketsa palo ea li-receptor tsa LDL holim'a li-hepatocytes, tse lebisang ho ho eketseha le ho ts'oaroa ha LDL, thibelo ea motsoako oa VLDL, ho fokotsa kakaretso ea LDL le VLDL. E fokotsa mokokotlo oa LDL-C, HDL cholesterol-non-lipoproteins (HDL-non-HDL), HDL-V, cholesterol e felletseng, TG, TG-VLDL, apolipoprotein B (ApoV), e fokotsa karolelano ea LDL-C / LDL-C, kakaretso HDL-C, Chs-eseng HDL-C / HDL-C, ApoB / apolipoprotein A-1 (ApoA-1) e eketsa likhahla tsa HDL-C le ApoA-1.

Phello ea ho fokotsa lipid e lekana ka kotloloho le tekanyo ea tekanyo e boletsoeng. Phello ea kalafo e hlahella ka hara beke 1 kamora ho qala kalafo, kamora libeke tse peli e fihla ho 90% ea boholo, e fihla hofihlella ka libeke tse 4 ebe e lula e le joalo.

Tafole 1. Phello e itšetlehileng ka tekanyetso ho bakuli ba nang le hypercholesterolemia ea mantlha (mofuta oa IIa le IIb ho latela sehlopha sa Fredrickson) (phetoho e tloaelehileng ea liperesente ha e bapisoa le boleng ba pele)

Dose	Palo ea bakuli	HS-LDL	Kakaretso ea kakaretso	HS-HDL
Sebaka sa sebaka	13	-7	-5	3
10 mg	17	-52	-36	14
20 mg	17	-55	-40	8
40 mg	18	-63	-46	10
Dose	Palo ea bakuli	TG	Xc- e seng HDL	Apo v	Apo AI
Sebaka sa sebaka	13	-3	-7	-3	0
10 mg	17	-10	-48	-42	4
20 mg	17	-23	-51	-46	5
40 mg	18	-28	-60	-54	0

Tafole 2. Phello e itšetlehileng ka tekanyetso ho bakuli ba nang le hypertriglyceridemia (mofuta IIb le IV ho ea ka phapanyetsano ea Fredrickson) (phetoho e tloaelehileng ea liperesente ha e bapisoa le boleng ba pele)

Dose	Palo ea bakuli	TG	HS-LDL	Kakaretso ea kakaretso
Sebaka sa sebaka	26	1	5	1
10 mg	23	-37	-45	-40
20 mg	27	-37	-31	-34
40 mg	25	-43	-43	-40
Dose	Palo ea bakuli	HS-HDL	Xc- e seng HDL	Xc- VLDL	TG- VLDL
Sebaka sa sebaka	26	-3	2	2	6
10 mg	23	8	-49	-48	-39
20 mg	27	22	-43	-49	-40
40 mg	25	17	-51	-56	-48

Ho sebetsa hantle ha kliniki

E sebetsa hantle ho bakuli ba baholo ba nang le hypercholesterolemia e nang le kapa ntle le hypertriglyceridemia, ho sa tsotelehe hore na ke ba morabe ofe, bong kapa lilemo. ho bakuli ba nang le lefu la tsoekere mellitus le hypercholesterolemia ea malapa. Ho 80% ea bakuli ba nang le mofuta oa IIa le IIb hypercholesterolemia (ho latela sehlopha sa Fredrickson) ba nang le karolelano ea mantlha ea LDL-C e ka bang 4,8 mmol / L, ha ba ntse ba sebelisa lithethefatsi ka tekanyetso ea 10 mg, khatello ea LDL-C e fihla tlase ho 3 mmol / L.

Ho bakuli ba nang le heterozygous Familyal hypercholesterolemia ba fumanang rosuvastatin ka tekanyo ea 20-80 mg / ka letsatsi, ho ile ha bonoa tšusumetso e ntle ea profid ea lipid. Kamora ho kenella litekong tsa letsatsi le letsatsi tsa 40 mg (libeke tse 12 tsa kalafo), ho fokotseha hoa khatello ea LDL-C ke 53% ho hlokometsoe. Ho bakuli ba mashome a mararo a metso e meraro (33%) ea bakuli, lenane la LDL-C le ka tlase ho 3 mmol / L le fihletsoe.

Ho bakuli ba nang le homozygous Familyal hypercholesterolemia ba fumanang rosuvastatin ka lethal dose ea 20 mg le 40 mg, ho fokotseha ho hoholo ha khatello ea LDL-C ho ne ho le 22%.

Ho bakuli ba nang le hypertriglyceridemia ba nang le khatello ea mantlha ea TG ho tloha ho 273 mg / dL ho isa ho 817 mg / dL, ba amohelang rosuvastatin ka tekanyetso ea 5 mg ho isa ho 40 mg 1 nako / letsatsi bakeng sa libeke tse 6, khatello ea TG maling a mali e fokotsehile haholo (bona tafole 2 )

Phello ea tlatsetso e bonoa hammoho le fenofibrate ha e bapisoa le khatello ea kelello ea TG le nicotinic acid ho lipid tse fokotsang litekanyetso (tse fetang 1 g / letsatsi) mabapi le khatello ea HDL-C.

Phuputsong ea METEOR, kalafo ea rosuvastatin e fokotsitse sekhahla sa tsoelo-pele ea boholo bo boholo ba "intima-media complex" (TCIM) bakeng sa likarolo tse 12 tsa mokokotlo oa carotid ha o bapisoa le placebo. Ha ho bapisoa le litekanyetso tsa motheo sehlopheng sa rosuvastatin, ho fokotseha ha TCIM e phahameng ka 0.0014 mm / selemo ho ile ha bonoa ha ho bapisoa le keketseho ea letšoao lena ka 0.0131 mm / selemo sehlopheng sa placebo. Ho fihla joale, kamano e tobileng pakeng tsa ho fokotseha ha TCIM le ho fokotseha ha menyetla ea liketsahalo tsa pelo ha e so bontšoe.

Liphetho tsa boithuto ba JUPITER li bonts'itse hore rosuvastatin e fokotse haholo kotsi ea ho ba le mathata a pelo le phokotseho ea kotsi ea 44%. Ho sebetsa hantle ha kalafo ho ile ha bonoa kamora likhoeli tse 6 tsa pele tsa ho sebelisa moriana. Ho bile le ho fokotseha ho hoholo ha lipalo ho 48% ho ntlha e kopaneng, ho kenyelletsa le lefu le bakoang ke pelo, ho fokotseha hoa lefu la 54% ha motho a bolaoa kapa a sa bolaee motho ka boeena, le 48% ea lefu le bolaeang kapa le sa bolaeang. Ho shoa ha batho ka kakaretso ho fokotsehile ka 20% sehlopheng sa rosuvastatin. Boemo ba polokeho ho bakuli ba nkang rosuvastatin ea 20 mg hangata bo ne bo tšoana hantle le boemo ba polokeho sehlopheng sa placebo.

Mofumahali

Kamora ho sebelisa moriana kahare ho C_max plasma rosuvastatin e fihlelloa hoo e ka bang ka lihora tse 5. Biooavailability e ka bang 20%.

Ho kopanya liprotheine tsa plasma (haholo-holo ke albin) ke hoo e ka bang 90%. V_d - 134 l.

Rosuvastatin e ananeloa haholo ke sebete, e leng sebaka sa mantlha sa tlhahiso ea Chs le metabolism ea Chs-LDL.

E kenella ka har'a sethopo sa placental.

Biotransformed ka har'a sebete ho isa hanyane (hoo e ka bang 10%), e le karolo e senang motheo ea isoenzymes ea cytochrome P450 system.

Leihloenzyme le ka sehloohong le amehang ho metabolism ea rosuvastatin ke isoenzyme CYP2C9. Isoenzymes CYP2C19, CYP3A4 le CYP2D6 ha li amehe haholo ho metabolism.

Li-metabolites tse ka sehloohong tsa rosuvastatin ke N-dismethyl le lactone metabolites. N-dismethyl e batla e le 50% e sa sebetseng ho feta rosuvastatin, metabolite ea lactone ha e sebetse. Ho feta 90% ea ts'ebetso ea meriana ho thibela ho potoloha HMG-CoA reductase e fanoa ke rosuvastatin, tse ling kaofela ke metabolites.

Joalo ka litaba tse ling tsa HMG-CoA reductase inhibitors, mokhanni ea khethehileng oa membrane o kenella ts'ebetsong ea ho ts'oaroa hoa lithethefatsi - polypeptide e tsamaisang organion anion (OATP) 1B1, e phethang karolo ea bohlokoa ho feliseng hoa eona ea hepatic.

T_1/2 - hoo e ka bang lihora tse 19, ha e fetohe ka tekanyetso e ntseng e eketseha. Tlatsetso e tloaelehileng ea plasma ke hoo e ka bang 50 l / h (coeffanele ea phapang 21.7%). Hoo e ka bang karolo ea 90% ea lethal dose la rosuvastatin e fetotsoe e sa fetoloe ka mala, e meng ke liphio.

Ts'ebetso ea kemiso ea rosuvastatin e eketseha ka tekanyo ea lethal dose.

Litekanyetso tsa Pharmacokinetic ha li fetohe ka tšebeliso ea letsatsi le letsatsi.

Pharmacokinetics maemong a khethehileng a kliniki

Bakeng sa bakuli ba nang le ho fokola ha reisal e leka-lekaneng, khatello ea plasma ea rosuvastatin kapa N-dysmethyl ha e fetohe haholo. Ho bakuli ba nang le bothata bo matla ba renal insuffasure (CC ka tlase ho 30 ml / min), khatello ea rosuvastatin ho plasma e makhetlo a 3 ho feta, 'me N-dysmethyl e phahame makhetlo a 9 ho feta ho baithaopi ba phetseng hantle. Khetla ea plasma ea rosuvastatin ho bakuli ba hemodialysis e batla e le 50% e phahame ho feta ho baithaopi ba phetseng hantle.

Ho bakuli ba nang le ts'oaetso ea sebete e nang le lintlha tse 7 kapa tse tlase ho tekanyo ea bana-Pugh, ha ho na keketseho ho T_1/2 rosuvastatin, ho bakuli ba nang le bothata ba sebete bo sa sebetseng 8 le 9 ka sekhahla sa ngoana-Pugh, ho ile ha hlokomeloa hore_1/2 Makhetlo a 2. Ha ho na boiphihlelo ka tšebeliso ea lithethefatsi ho bakuli ba nang le ts'ebetso e matla ea sebete.

Bong le lilemo ha li na phello ea bohlokoa litabeng tsa pharmacokinetics ea rosuvastatin.

Litekanyetso tsa pharmacokinetic tsa rosuvastatin li itšetlehile ka lebelo. AUC ea baemeli ba lebelo la Mongoloidid (Majapane, Machaena, Mafilipino, Vietnam le Korena) e phahame makhetlo a mabeli ho feta ea lebelo la Caucasus. Maindia a mahareng a AUC le C_max e eketsehile ka makhetlo a 1,3.

HMG-CoA reductase inhibitors, ho kenyelletsa rosuvastatin e tlama ho liprotheine tsa lipapatso tsa OATP1B1 (polypeptide ea organic anion e amehang ho ts'oarisong ea hepatocyte ea li-statins) le BCRP (efflux transporter). Bakuli ba genotypes SLCO1B1 (OATP1B1) s.521CC le ABCG2 (BCRP) s.421AA e bonts'itse keketseho ea tlhahiso (AUC) ho rosuvastatin 1.6 le makhetlo a 2.4, ka ho bapisoa, le bapisoa le bajari ba genotypes SLCO1B1 s.521TT le ABCG2 s.421CC.

- hypercholesterolemia (mofuta IIa ho ea ka Fredrickson), ho kenyelletsa heterozygous hypercholesterolemia kapa hypercholesterolemia (mofuta IIb ho ea ka Fredrickson) - e le tlatsetso ea lijo, ha ho ja le mekhoa e meng e seng ea lithethefatsi (mohlala, boikoetliso ba 'mele, ho theola boima ba' mele) ha li lekane

- lelapa homozygous hypercholesterolemia - e le tlatsetso ea lijo le kalafo e meng e fokotsang lipid (mohlala, LDL-apheresis), kapa maemong ao kalafo e joalo e sa sebetseng ka ho lekana,

- hypertriglyceridemia (mofuta oa IV ho ea ka Fredrickson) - e le tlatsetso ea lijo,

- Ho liehisa tsoelo-pele ea atherosulinosis - e le tlatsetso ea lijo ho bakuli ba bontšitsoeng kalafo ho fokotsa bongata ba Chs le Chs-LDL,

- Thibelo ea mantlha ea mathata a maholo a pelo (lefu la pelo, ho nyekeloa ke pelo, masapo a methapo) ho bakuli ba baholo ntle le matšoao a lefu la methapo ea methapo, empa ba na le monyetla oa ho hola ha bona (ba ka holimo ho lilemo tse 50 bakeng sa banna le ba lilemo tse fetang 60 bakeng sa basali, bongata ba protheine ea C-reactive. (≥ 2 mg / l) boteng ba bonyane ba mabaka a mang a tlatsetso a kotsi, joalo ka khatello ea mali ea methapo, khatello e tlase ea HDL-C, ho tsuba, nalane ea lelapa ea ho qala ha lefu la pelo la pelo).

Melemo ea litekanyetso

Setlhare se nooa ka molomo. Matlapa a lokela ho metsoa a felletse, ntle le ho hlafuna mme a sa sithabe, a hlatsoe ka metsi, ka nako efe kapa efe ea letsatsi, ho sa tsotelehe lijo tse ngata.

Pele a qala kalafo ka Rosucard ®, mokuli o lokela ho qala ho latela lijo tse tloaelehileng tsa lipid mme a tsoele pele ho li latela nakong ea kalafo.

Tekanyetso ea moriana e lokela ho khethoa ka bonngoe ho latela matšoao le karabelo ea kalafo, ho nahana ka litlhahiso tsa morao-rao tse amoheloang hangata bakeng sa ho tsepamisoa ho lipid.

Motsoako oa mantlha oa Rosucard ® o khothalelitsoeng ho bakuli ba qalang ho sebelisa moriana, kapa oa bakuli ba fetisitsoeng ho nka li-inhibitors tse ling tsa HMG-CoA, ke 5 kapa 10 mg 1 nako / letsatsi.

Ha u khetha tekanyetso ea pele, motho o lokela ho tataisoa ke k'holeseterole ea mokuli mme a nahane ka kotsi ea ho ba le mathata a pelo, hape ho hlokahala hore ho hlahlojoe kotsi e ka bang le litlamorao. Haeba ho hlokahala, kamora libeke tse 4 tekanyetso ea moriana e ka eketseha.

Ka lebaka la nts'etsopele ea litla-morao ha ho nooa moriana ka tekanyo ea 40 mg, ha ho bapisoa le litekanyetso tse tlase tsa lithethefatsi, karabelo ea ho qetela ea tekanyo e phahameng ea 40 mg e lokela ho etsoa feela ho bakuli ba nang le hypercholesterolemia e kholo le kotsi e kholo ea mathata a pelo (haholo ho bakuli le hereditary hypercholesterolemia), eo ka eona ha ho nooa moriana ka tekanyetso ea 20 mg, boemo ba cholesterol bo neng bo sa fihlelleha ha boa ka ba atleha. Bakuli ba joalo ba lokela ho ba tlas'a tlhokomelo ea bongaka. Ho khothalletsoa haholo-holo ho hlokomela bakuli ba fumanang moriana ka tekanyetso ea 40 mg.

Tekanyetso ea 40 mg ha e khothalletsoe ho bakuli ba e-s'o ka ba etela ngaka pele. Kamora libeke tse 2 ho ea ho tse ling tsa kalafo le / kapa ka keketseho ea tekanyetso ea Rosucard ®, hoa hlokahala ho lekola metabolism ea lipid (phetoho ea litekanyetso e hlokahala ha ho hlokahala).

Ho bakuli ba tsofetseng ba fetang 65 tokiso ea tekanyetso ha e hlokehe.

Ho bakuli ba nang le bothata ba sebete ka makgabane Ka tlase ho lintlha tse 7 ka sekhahla sa bana-Prag tokiso ea litekanyetso tsa Rosucard ha e hlokehe.

Ho bakuli ba nang le bothata ba ho hlaba hantle ba masapotokiso ea litekanyetso tsa moriana Rosucard ® ha e hlokehe, ho khothaletsoe tekanyetso ea pele ea 5 mg / ka letsatsi. Ho bakuli ba nang le bothata ba ho leka-lekanya ha reculical (CC 30-60 ml / min) tšebeliso ea lithethefatsi Rosucard ® ka lethal dose ea 40 mg / ka letsatsi e tšoaetsitsoe. Ho ho hloleha ho matla ha renal (CC ka tlase ho 30 ml / min) tšebeliso ea lithethefatsi Rosucard ® e patiloe.

Ho bakuli ba nang le bothata ba ho tseba litaba tsa myopathy tšebeliso ea lithethefatsi Rosucard ® ka lethal dose ea 40 mg / ka letsatsi e tšoaetsitsoe. Ha u fana ka litlhare ho tekanyetso ea 10 mg le 20 mg / ka letsatsi, tekanyetso ea pele ea sehlopha sena ea bakuli ke 5 mg / ka letsatsi.

Ha re ithuta ka litekanyetso tsa pharmacokinetic tsa rosuvastatin, keketseho ea tsamaiso ea lithethefatsi ho baemeli e ile ea lemohuoa. Mofuta oa Mongoloid. Ntlha ena e lokela ho ananeloa ha ho fanoa ka taelo ea Rosucard ® ho bakuli ba morabe oa Mongoloid. Ha u fana ka litlhare ho litekanyetso tsa 10 mg le 20 mg, tekanyetso ea pele ea sehlopha sena ea bakuli ke 5 mg / ka letsatsi. Ts'ebeliso ea lithethefatsi Rosucard ® ka tekanyo ea 40 mg / ka letsatsi ho baemeli ba mofuta oa Mongoloid e tiisitsoe.

Polymorphism ea liphatsa tsa lefutso. Bakuli ba genotypes SLCO1B1 (OATP1B1) c.521CC le ABCG2 (BCRP) c.421AA e bonts'itse keketseho ea tlhahiso (AUC) ea rosuvastatin ha e bapisoa le bajari ba genotypes SLC01B1 s.521TT le ABCG2 s.421CC. Bakeng sa bakuli ba nang le genotypes c.521SS kapa c.421AA, lethal dose le khothalletsoang la Rosucard ® ke 20 mg / ka letsatsi.

Pheko e lumellanang. Rosuvastatin e tlama ho liprotheine tse fapaneng tsa lipalangoang (haholo-holo, OATP1B1 le BCRP). Ha moriana oa Rosucard ® o sebelisoa hammoho le lithethefatsi (joalo ka cyclosporine, li-inhibitors tse ling tsa HIV, ho kenyeletsa le motsoako oa ritonavir le atazanavir, lopinavir le / kapa tipranavir), tse eketsang khatello ea mali ea rosuvastatin ka plasma ea mali ka lebaka la ho sebelisana le liprotheine tsa lipalangoang, kotsi ea myopathy e ka eketseha (ho kenyelletsa le rhabdomyolysis). Maemong a joalo, o lokela ho hlahloba monyetla oa ho fana ka phekolo e 'ngoe kapa ho emise tšebeliso ea Rosucard ® nakoana. Haeba ts'ebeliso ea lithethefatsi tse kaholimo e hlokahala, o lokela ho tloaelana le litaelo tsa ho sebelisa lithethefatsi pele o li ngola ka nako e le ngoe le Rosucard ®, lekola sekhahla sa menyetla ea phekolo e kopaneng mme o nahane ka ho fokotsa tekanyetso ea Rosucard ®.

Litla-morao

Litla-morao tse bonoang ka rosuvastatin hangata li bobebe ebe lia ikela. Joalo ka li-inhibitors tse ling tsa HMG-CoA reductase, liketsahalo tsa litlamorao li haholo-holo li thehiloe ho lethalinyana.

Ka tlase ke setšoantšo sa karabelo e mpe ea rosuvastatin, e thehiloeng ho datha ho tsoa lithutong tsa kliniki le boiphihlelo bo pharaletseng ba ho ngolisa.

Boikemisetso ba khafetsa ea likarabelo tse bohloko (ho beoa ha WHO): hangata khafetsa (> 1/10), hangata (ho tloha ho 1/100 ho isa ho 1/1000 ho isa ho 1/10 000 ho isa ho 20 mg / ka letsatsi, hangata haholo - arthralgia, tendopathy, mohlomong ka Ho phatloha ha tendon, khafetsa ha e tsejoe - immuno-mediated necrotizing myopathy.

Litla-morao: hangata - ho hlohlona ha letlalo, urticaria, lekhopho, hangata - litlamorao tsa hypersensitivity, ho kenyeletsa angioedema.

Ka lehlakoreng la letlalo le lisele tse nyane: maqhubu a sa tsejoeng - lefu la Stevens-Johnson.

Ho tsoa ts'ebetsong ea moroto: hangata - proteinuria, ka seoelo - hematuria. Liphetoho ho palo ea liprotheine tse ngata ka har'a moroto (ho tloha ho ba sieo kapa ho lekana ho isa ho ++ kapa ho feta) li bonoa ka tlase ho 1% ea bakuli ba fumanang lethal dose ea 10-20 mg / ka letsatsi, le ho bakuli ba ka bang 3% ba amohelang 40 mg / ka letsatsi. Proteinuria e fokotseha nakong ea kalafo mme ha e tsamaisane le ho ba teng ha lefu la liphio kapa ts'oaetso ea ts'ebetso ea urine

Ho tsoa ho liphatsa tsa lefutso le tšoelesa e anyesang: ka seoelo - gynecomastia.

Matšoao a laboratori: ka tsela e sa lekanyetsoang - keketseho e thehiloeng ke lethalinyana ea tšebetso ea CPum ea serum (maemong a mangata, e sa bohlokoa, asymptomatic le ea nakoana). Ka keketseho ea makhetlo a fetang a 5 ha a bapisoa le VGN, phekolo le Rosucard ® e lokela ho emisoa ka nakoana. Keketseho ea "plogma" ea hemoglobin ea plasma e eketsehileng.

Tse ling: khafetsa - asthenia, khafetsa ha e tsejoe - haufi le edema.

Ha u sebelisa Rosucard ®, liphetoho li ile tsa lemohuoa ka liparamente tse latelang tsa laboratori: keketseho ea khatello ea tsoekere, bilirubin, ts'ebetso ea alkaline phosphatase, le GGT.

Nts'etsopele ea liketsahalo tse latelang tse bohloko e tlalehiloe nakong ea ts'ebeliso ea li-statins tse ling: ho senyeha ha erectile, liketsahalo tse arohaneng tsa lefu la matšoafo a mahareng (haholo-holo ka tšebeliso e telele), mofuta oa 2 lefu la tsoekere, khafetsa ea nts'etsopele ea ona e itšetlehileng ka ho ba teng kapa ho se be teng hoa mabaka a kotsi (khatello ea mali ea glucose ea 5.6- 6.9 mmol / l, BMI> 30 kg / m 2, hypertriglyceridemia, nalane ea khatello ea mali ea methapo).

Contraindication

Bakeng sa matlapa a 10 le 20 mg

- Hypersensitivity ho likarolo tsa moriana,

- lefu la sebete sehlopheng se sebetsang kapa keketseho e tsitsitseng ea ts'ebetso ea hepatic transaminases ho serum (ho feta makhetlo a 3 ha a bapisoa le VGN) ea tšimolohong e sa tsejoeng.

- ho hloleha ha sebete (botebo ba ho tloha ho lintlha tse 7 ho isa ho tse 9 ho sekhahla sa bana),

- Keketseho ea khatello ea CPK maling ka makhetlo a fetang a 5 ha a bapisoa le VGN,

- ho senya haholo renal (CC ka tlase ho 30 ml / min),

- bakuli ba rerileng ho nts'etsapele mathata a bophelo ba ka,

- tsamaiso e tšoanang ea cyclosporine,

- ts'ebeliso e kopaneng le li-inhibitors tsa HIV,

- mafu a lefutso, a joalo ka ho se mamelle lactose, khaello ea lactase kapa malabsorption ea glucose-galactose (ka lebaka la ho ba teng ha lactose sebopeho),

- basali ba lilemo tsa ho ba le bana ba sa sebeliseng mekhoa e lekaneng ea ho thibela pelehi,

- ho anyesa (matsoele),

- lilemo ho isa ho lilemo tse 18 (katleho le polokeho ha li e-so theoe),

Bakeng sa matlapa a 40 mg (ho ekelletsa ho li-contraindication tsa matlapa a 10 le 20 mg)

Ho ba teng hoa lintlha tse latelang tsa kotsi bakeng sa nts'etsopele ea myopathy / rhabdomyolysis:

- myotoxicity khahlanong le semelo sa ts'ebeliso ea li-inhibitors tse ling tsa HMG-CoA reductase kapa li-fibrate nalaneng,

- ho se sebetse hantle haholo ha boima ba 'mele bo leka-lekane (CC 30-60 ml / min),

- lino tse tahang haholo

- maemo a ka lebisang hoketsisong ea plasma ea rosuvastatin,

- kamohelo e ts'oanang ea li-fibrate.

Bakuli ba morabe oa Mongoloid.

Matšoao a lefu la mesifa nalaneng ea lelapa.

Bakeng sa matlapa a 10 le 20 mg: ka nalane ea lefu la sebete, sepsis, arterial hypotension, opereishene e ngata, ho sithabela maikutlo, ho ruruha haholo ha methapo ea kutlo, endocrine kapa li-electrolyte, ho tsitsipana ho sa laoleheng, ka bonolo le ho se sebetse hantle ha renal, hypothyroidism, ka ts'ebeliso ea li-inhibitors kapa li-fibrate tse ling tsa HMG-CoA. matšoao a nalane ea chefo ea mesifa, mafu a amanang le mesifa ho anamnesis, taolo e ts'oanang ka li-fibrate, maemo ao keketseho ea khatello ea maikutlo le rosuvastatin ka lero la mali mali ka bakuli ba lilemo li fetang 65 lilemo tse, le Mongoloid peiso bakuli ba noang joala ka tsela e feteletseng.

Bakeng sa matlapa a 40 mg: ka ho se sebetse hantle ha renal (CC ho feta 60 ml / min), nalane ea lefu la sebete, sepsis, hypotension ea methapo, ts'ebetso e kholo ea ts'ebetso ea ho buoa, likotsi, metabolism e matla, endocrine kapa mathata a electrolyte, ts'ebeliso e sa laoleheng, ho bakuli ba lilemo tse fetang 65.

Bokhachane le pelehi

Rosucard ® e kopantsoe le ho ima le ho nyekeloa.

Tšebeliso ea Rosucard ® basali ba lilemo tsa ho ba le banaka etsahala ha feela ho sebelisoa mekhoa e tšepahalang ea ho thibela pelehi le ha mokuli a tsebisoa ka kotsi e ka bang teng ea kalafo ho lesea.

Kaha cholesterol le lintho tse kopantsoeng ho tloha ho cholesterol li bohlokoa holima nts'etsopele ea bokhachane, kotsi e ka bang teng ea ho thibela phallo ea HMG-CoA e feta melemo ea ho sebelisa lithethefatsi nakong ea kemolo. Haeba ho ima ho fumanoa nakong ea kalafo le moriana, Rosucard ® e lokela ho emisoa hang-hang, 'me mokuli o lokela ho lemosoa ka kotsi e ka bang teng ho lesea.

Haeba ho hlokahala ho sebelisa moriana nakong ea lebese, ha ho fanoe ka monyetla oa liketsahalo tse bohloko ho masea, taba ea ho emisa ho anyesa e lokela ho rarolloa.

Litaelo tse khethehileng

Tšusumetso lipelong

Ho bakuli ba fumanang litekanyetso tse phahameng tsa rosuvastatin (haholo-holo 40 mg), proteinuria ea tubular e ile ea bonoa, eo maemong a mangata e neng e le ea nakoana. Proteinia e joalo e ne e sa bontše lefu le matla la liphio kapa tsoelo-pele ea lefu la liphio. Bakeng sa bakuli ba noang moriana ka tekanyo ea 40 mg, ho khothalletsoa ho lekola matšoao a ts'ebetso ea a renal nakong ea kalafo.

Tšusumetso ho sistimi ea musculoskeletal

Ha u sebelisa rosuvastatin ho litekanyetso tsohle, mme haholo litekanyetso tsa 20 mg, ho tlalehiloe litlamorao tse latelang tsamaisong ea musculoskeletal: myalgia, myopathy, maemong a sa tloaelehang, rhabdomyolysis.

Qeto ea mosebetsi oa CPK

Boikemisetso ba ts'ebetso ea CPK ha boa lokela ho etsoa ka mor'a ho ikoetlisa ka matla kapa ka lebaka la mabaka a mang a keketseho ea ketsahalo ea CPK, e ka lebisang ho toloko e fosahetseng ea sephetho. Haeba ts'ebetso ea pele ea CPK e eketsehile haholo (makhetlo a 5 a phahame ho VGN), kamora matsatsi a 5-7, ho lokela ho etsoa tekanyo ea bobeli. Phekolo ha ea lokela ho qala haeba tlhahlobo e pheta-phetoang e netefatsa ts'ebetso ea pele ea KFK (makhetlo a fetang 5 ho feta VGN).

Pele o qala kalafo

Ha u sebelisa Rosucard ®, hammoho le ha u sebelisa li-inhibitors tse ling tsa HMG-CoA reductase, tlhokomeliso e lokela ho ba teng ho bakuli ba nang le mabaka a teng a kotsi a myopathy / rhabdomyolysis. Tekanyo ea melemo ea kotsi e lokela ho hlahlojoa, mme ha ho hlokahala, tlhahlobo ea bongaka ea mokuli e lokela ho etsoa nakong ea kalafo.

Nakong ea kalafo

Tsebisa mokuli ka tlhoko ea ho tsebisa ngaka hanghang ka maemo a bohloko ba mesifa, ho fokola ha mesifa kapa ho putlama, haholoholo mmoho le malaise le feberu. Ho bakuli ba joalo, ts'ebetso ea CPK e lokela ho ikemisetsa. Phekolo e lokela ho khaotsa haeba ts'ebetso ea CPK e eketsehile haholo (makhetlo a fetang 5 ho feta VGN) kapa haeba matšoao a karolo ea mesifa a boleloa mme a baka tsitsipano ea letsatsi le letsatsi (leha ts'ebetso ea KFK e le tlase ho makhetlo a 5 ha e bapisoa le VGN). Haeba matšoao a nyamela, mme ts'ebetso ea CPK e khutlela ho e tloaelehileng, ho lokela ho nahanoa ho fana ka litlhaloso tsa Rosucard ® kapa li-inhibitors tse ling tsa HMG-CoA tse fokotsang litekanyetso tse tlase ka ho shebella mokuli ka hloko.

Ho lekola ka linako tsohle tšebetso ea CPK ka ha matšoao a ho hloka letho ho ke ke ha thusa. Ho ile ha lemohuoa linyeoe tse sa tloaelehang haholo tsa myopathy e fokotsang matla ea mmele ea ho itšireletsa mafung ka mokhoa oa bofokoli bo sa feleng ba mesifa ea proximal le keketseho ea ts'ebetso ea CPK serumeng ea mali nakong ea kalafo kapa ha ho nkoa li-statins, ho kenyelletsa le rosuvastatin. Boithuto bo eketsehileng ba mesifa le tsamaiso ea methapo, lithuto tsa serological, hammoho le kalafo ea immunosuppressive li ka hlokahala. Ho ne ho se na matšoao a ho eketseha ha mesifa ea marapo ha u nka rosuvastatin le kalafo e kopanetsoeng. Leha ho le joalo, ho ata ha liketsahalo tsa myositis le myopathy ho tlalehiloe ho bakuli ba nkang li-inhibitors tse ling tsa HMG-CoA reductase hammoho le li-derivatives tsa fibric acid, ho kenyelletsa le gemfibrozil, cyclosporine, nicotinic acid ho litekanyetso tsa hypolipidemic (ho feta 1 g / letsatsi), azole antifungal agents, inhibitors Liprotheine tsa HIV le lithibela-mafu tsa macrolide. Gemfibrozil e eketsa kotsi ea myopathy ha e sebelisoa hammoho le li-inhibitors tse ling tsa HMG-CoA reductase. Kahoo, tšebeliso e tšoanang ea lithethefatsi Rosucard ® le gemfibrozil ha e khothalletsoe. Tekanyo ea kotsi le melemo e ka bang teng e lokela ho lekanngoa ka hloko ha rosucard ® e sebelisoa hammoho le methapo ea methapo ea methapo kapa hypolipidemic ea nicotinic acid. Ts'ebeliso ea moriana Rosucard ® ka lethal dose ea 40 mg hammoho le li-fibrate li kopantsoe. Libeke tse 2-4 kamora ho qala kalafo le / kapa ka keketseho ea tekanyetso ea Rosucard ®, ho netefatsa metabolism ea lipid hoa hlokahala (ho hlokahala hore ho fetoloe tekanyo ea litekanyetso haeba ho hlokahala).

Ho khothalletsoa ho khetholla matšoao a ts'ebetso ea sebete pele ho qala kalafo le likhoeli tse 3 kamora ho qala kalafo. Ts'ebeliso ea moriana Rosucard ® e lokela ho emisoa kapa tekanyetso ea lithethefatsi e lokela ho fokotsoa haeba ts'ebetso ea li-transaminase tsa hepatic ka plasma ea mali e le makhetlo a 3 ho feta VGN.

Ho bakuli ba nang le hypercholesterolemia ka lebaka la hypothyroidism kapa nephrotic syndrome, kalafo ea mafu a mantlha e lokela ho etsoa pele ho kalafo le Rosucard ®.

Li-inhibitors tsa HIV

Ts'ebeliso e kopaneng ea moriana Rosucard ® le li-inhibitors tsa HIV tsa HIV ha e khothalletsoe.

Lefu la matšoafo a matšoafo

Ha u sebelisa li-statin tse itseng, haholo-holo nako e telele, ho tlalehiloe mafu a ka thoko a lefu la matšoafo a kahare. Liponahatso tsa lefu lena li ka kenyelletsa ho hema hanyane, ho khohlela ho sa beheng, le ho phela hantle ka kakaretso (bofokoli, ho fokotsa boima ba 'mele le feberu). Haeba u belaella lefu le amang masapo la matšoafo, ho hlokahala hore o emise kalafo ka Rosucard ®.

Type 2 lefu la tsoekere

Lithethefatsi tsa Statin li ka baka keketseho ea khatello ea mali ea mali. Ho bakuli ba bang ba nang le kotsi e kholo ea ho ba le lefu la tsoekere la mellitus, liphetoho tse joalo li ka lebisa ponahalong ea hae, e leng sesupo sa ho khethoa ha kalafo ea hypoglycemic. Leha ho le joalo, ho fokotseha ha menyetla ea ho tšoaroa ke lefu la vascular le li-statins ho eketsa kotsi ea ho tšoaroa ke lefu la tsoekere, ka hona, ntlha ena ha ea lokela ho sebetsa e le motheo oa ho hlakola kalafo ea statin. Bakuli ba kotsing (ho itima lijo ka sekhahla sa tsoekere ea mali e ka bang 5.6-6.9 mmol / L, BMI> 30 kg / m 2, nalane ea hypertriglyceridemia, le khatello ea mali ea methapo) ba lokela ho feta tlhatlhobong ea bongaka le ho lekola khafetsa litekanyetso tsa biochemical.

Rosucard ® ha ea lokela ho sebelisoa ho bakuli ba nang le khaello ea lactase, ho se mamellane ha galactose le malabsorption ea glucose-galactose.

Nakong ea lithuto tsa pharmacokinetic har'a bakuli ba Machaena le Majapane, keketseho ea systemic ea rosuvastatin e ile ea bonoa ha e bapisoa le matšoao a fumanoeng har'a bakuli ba morabe oa Caucasian.

Tšusumetso ho bokhoni ba ho khanna makoloi le litsamaiso tsa taolo

Ho lokela ho ba hlokolosi ha ho khannoa likoloi le liketso tse hlokang ho tsepamisa mohopolo le lebelo le ho feta ha maikutlo a psychomotor (ho tsekela ho ka etsahala nakong ea kalafo).

Bongata

Ka tsamaiso e tšoanang ea litekanyetso tse 'maloa tsa letsatsi le letsatsi, litekanyetso tsa pharmacokinetic tsa rosuvastatin ha li fetohe.

Phekolo: ha ho na kalafo e tobileng, kalafo ea matšoao e etsoa ho boloka mesebetsi ea litho tsa bohlokoa le litsamaiso. Hoa hlokahala ho hlokomela matšoao a ts'ebetso ea sebete le ts'ebetso ea CPK. Hemodialysis ha e na thuso.

Ho sebelisana le lithethefatsi

Matla a lithethefatsi tse ling ho rosuvastatin

Lintho tse thibelang liproteine ​​tse tsamaeang: rosuvastatin e tlama ho liprotheine tse itseng tsa lipalangwang, haholo-holo OATP1B1 le BCRP.Ts'ebeliso e lekanang ea lithethefatsi tse li-inhibitors tsa liprotheine e kanna ea tsamaisana le keketseho ea khatello ea rosuvastatin ho plasma ea mali le kotsi e eketsehang ea myopathy (bona tafoleng ea 3).

Cyclosporin: ka tšebeliso e tšoanang ea rosuvastatin le cyclosporine, AUC ea rosuvastatin e ne e phahame ka makhetlo a 7 ho feta e bonoang ke baithaopi ba phetseng hantle. Ha e ame khatello ea mali a cyclosporine. Rosuvastatin e tšoaelitsoe ho bakuli ba nkang cyclosporine.

Lithibela-mafu tsa protease tsa HIV: leha ho sa tsejoe mokhoa o nepahetseng oa tšebelisano, tšebeliso e kopaneng ea li-protease inhibitors tsa HIV e ka lebisa keketseho e kholo ponelisong ea rosuvastatin (sheba tafole ea 3). Phuputso ea pharmacokinetic ea tšebeliso e ts'oanang ea rosuvastatin ka tekanyo ea 20 mg le tokiso ea ho kopanya e nang le li-inhibitors tse peli tsa HIV (400 mg ea lopinavir / 100 mg ea ritonavir) ho baithaopi ba phetseng hantle e lebisitse keketseho e ka bang makhetlo a mabeli le a mahlano ho AUC (_0-24) le C_max rosuvastatin, ka ho latellana. Ka hona, tšebeliso e tšoanang ea lithethefatsi Rosucard ® le li-inhibitors tsa HIV ha e khothaletsoe (sheba tafole ea 3).

Gemfibrozil le lithethefatsi tse ling tse fokotsang lipid: ts'ebeliso e kopaneng ea rosuvastatin le gemfibrozil e lebisa keketseho ea makhetlo a 2 ho C_max le AUC ea rosuvastatin. Motheong oa data mabapi le litšebelisano tse ikhethang, ts'ebelisano e kholo ea pharmacokinetically le fenofibrate ha e lebelloe, litšebelisano tsa pharmacodynamic lia khoneha. Gemfibrozil, fenofibrate, fibrate tse ling, le nicotinic acid ho lipid li fokotsa tekanyetso (tse fetang 1 g / ka letsatsi) li eketsa kotsi ea myopathy ha e sebelisoa le HMG-CoA reductase inhibitors, mohlomong ka lebaka la hore li ka baka myopathy ha e sebelisoa ho joalo ka monotherapy. Ha a ntse a sebelisa lithethefatsi ka gemfibrozil, fibrate, acid e nicotinic ho lipid tse fokotsang litekanyetso, bakuli ba khothalletsoa tekanyetso ea pele ea Rosucard ® 5 mg, tekanyo ea 40 mg e kopantsoe hammoho le li-fibrate.

Fusidic asiti: ha ho lithuto tse tobileng tse entsoeng mabapi le tšebelisano ea lithethefatsi tsa fusidic acid le rosuvastatin, empa ho bile le litlaleho tse arohaneng tsa linyeoe tsa rhabdomyolysis.

Ezetimibe: tšebeliso e le 'ngoe ea lithethefatsi Rosucard ® ka tekanyo ea 10 mg le ezetimibe ka tekanyo ea 10 mg e ne e tsamaisana le keketseho ea AUC ea rosuvastatin ho bakuli ba nang le hypercholesterolemia (bona tafole ea 3). Ho ke ke ha khoneha ho khetholla kotsi e eketsehileng ea litlamorao ka lebaka la tšebelisano ea pharmacodynamic lipakeng tsa sethethefatsi Rosucard ® le ezetimibe.

Erythromycin: Tšebeliso e tšoanang ea rosuvastatin le erythromycin li lebisa ho fokotseheng ha AUC_(0-t) 20% rosuvastatin le C_max rosuvastatin 30%. Ho sebelisana ho joalo ho ka etsahala ka lebaka la matla a eketsehileng a mala a bakoang ke ho nka erythromycin.

Li-antacid: ts'ebeliso e ts'oanang ea rosuvastatin le ho emisoa ha li-antacids tse nang le aluminium kapa magnesium hydroxide, ho lebisa ho fokotseha hoa khatello ea plasma ea rosuvastatin ke hoo e ka bang 50%. Phello ena ha e hlahisoe ha li-antacid li sebelisoa lihora tse 2 kamora ho nka rosuvastatin. Bohlokoa ba ts'ebelisano ena ha bo so ithutoe.

Isoenzymes ea cytochrome P450 system: Ka lithuto tsa vivo le tsa vitro li bontšitse hore rosuvastatin ha se inhibitor kapa inducer ea cytochrome P450 isoenzymes. Ntle le moo, rosuvastatin ke karolo e fokolang ea li-enzyme tsena. Ka hona, ho sebelisana ha rosuvastatin le lithethefatsi tse ling maemong a metabolic a kenyelletsang cytochrome P450 isoenzymes ha hoa lebelloa. Ho ne ho se na tšebelisano ea bohlokoa lipakeng tsa rosuvastatin le fluconazole (inhibitor ea isoenzymes CYP2C9 le CYP3A4) le ketoconazole (anhibitor ea isoenzymes CYP2A6 le CYP3A4).

Ho sebelisana le lithethefatsi tse hlokang ho lokisoa ha li-rosuvastatin (sheba tafole ea 3)

Tekanyo ea rosuvastatin e lokela ho fetoloa haeba ho hlokahala, tšebeliso ea eona e kopaneng le lithethefatsi tse eketsang ponaletso ea rosuvastatin. Haeba keketseho ea ho pepesoa ha makhetlo a 2 kapa ho feta e lebelletsoe, tekanyetso ea pele ea Rosucard ® e lokela ho ba 5 mg 1 nako / letsatsi. Tekanyo e phahameng ea letsatsi le letsatsi ea Rosucard ® le eona e lokela ho fetoloa e le hore tlhahiso e lebelletsoeng ea rosuvastatin e se ke ea feta tekanyo ea 40 mg e nkuoeng ntle le taolo e ts'oanang ea lithethefatsi tse sebelisanang le rosuvastatin. Mohlala, tekanyetso e phahameng ea letsatsi le letsatsi ea rosuvastatin e sebelisoang ka nako e le 'ngoe le gemfibrozil ke 20 mg (keketseho ea ho pepesetsoa ka makhetlo a 1,9), ka ritonavir / atazanavir - 10 mg (keketseho ea tlhahiso ea linako ke makhetlo a 3.1).

Lethathamo la 3. Phello ea kalafo e kopanetsoeng ho pepesoa ha rosuvastatin (AUC, datha li bontšoa ka tatellano ea ho theoha) - liphetho tsa liteko tsa bongaka tse phatlalalitsoeng.

Mokhoa oa phekolo e lumellanang	Regimen ea Rosuvastatin	Phetoho ea AUC ho rosuvastatin
Cyclosporin 75-200 mg makhetlo a 2 / ka letsatsi, likhoeli tse 6	10 mg 1 nako / letsatsi, matsatsi a 10	Khanya ea 7.1x
Atazanavir 300 mg / ritonavir 100 mg 1 nako / letsatsi, matsatsi a 8	10 mg tekanyetso e le 'ngoe	Keketseho ea 3.1x
Simeprevir 150 mg 1 nako / letsatsi, matsatsi a 7	10 mg tekanyetso e le 'ngoe	Khanya ea 2.8x
Lopinavir 400 mg / ritonavir 100 mg makhetlo a 2 / ka letsatsi, matsatsi a 17	20 mg 1 nako / letsatsi, matsatsi a 7	Keketseho ea 2.1x
Clopidogrel 300 mg (lethal dose), joale 75 mg ka mora lihora tse 24	20 mg tekanyetso e le 'ngoe	Keketseho ea 2x
Gemfibrozil 600 mg makhetlo a 2 / ka letsatsi, matsatsi a 7	80 mg e le 'ngoe tekanyetso	Kholo ea 1.9x
Eltrombopag 75 mg 1 nako / letsatsi, matsatsi a 10	10 mg tekanyetso e le 'ngoe	Kholo ea 1.6x
Darunavir 600 mg / ritonavir 100 mg makhetlo a 2 / letsatsi, matsatsi a 7	10 mg 1 nako / letsatsi, matsatsi a 7	Linako tsa 1.5 li eketseha
Tipranavir 500 mg / ritonavir 200 mg makhetlo a 2 / ka letsatsi, matsatsi a 11	10 mg tekanyetso e le 'ngoe	Linako tsa 1.4 li eketseha
Dronwoodone 400 mg makhetlo a 2 / ka letsatsi	Ha ho na data	Linako tsa 1.4 li eketseha
Itraconazole 200 mg 1 nako / letsatsi, matsatsi a 5	10 mg kapa 80 mg hang	Linako tsa 1.4 li eketseha
Ezetimibe 10 mg 1 nako / letsatsi, matsatsi a 14	10 mg 1 nako / letsatsi, matsatsi a 14	Keketseho ea 1,2x
Fosamprenavir 700 mg / ritonavir 100 mg makhetlo a 2 / ka letsatsi, matsatsi a 8	10 mg tekanyetso e le 'ngoe	Ha ho na phetoho
Aleglitazar 0,3 mg, matsatsi a 7	40 mg, matsatsi a 7	Ha ho na phetoho
Silymarin 140 mg makhetlo a 3 / letsatsi, matsatsi a 5	10 mg tekanyetso e le 'ngoe	Ha ho na phetoho
Fenofibrate 67 mg makhetlo a 3 / ka letsatsi, matsatsi a 7	10 mg, matsatsi a 7	Ha ho na phetoho
Rifampin 450 mg 1 nako / letsatsi, matsatsi a 7	20 mg tekanyetso e le 'ngoe	Ha ho na phetoho
Ketoconazole 200 mg makhetlo a 2 / ka letsatsi, matsatsi a 7	80 mg e le 'ngoe tekanyetso	Ha ho na phetoho
Fluconazole 200 mg 1 nako / letsatsi, matsatsi a 11	80 mg e le 'ngoe tekanyetso	Ha ho na phetoho
Erythromycin 500 mg makhetlo a 4 / ka letsatsi, matsatsi a 7	80 mg e le 'ngoe tekanyetso	Phokotso ea 28%
Baikalin 50 mg makhetlo a 3 / letsatsi, matsatsi a 14	20 mg tekanyetso e le 'ngoe	Phokotso ea 47%

Matla a rosuvastatin ho lithethefatsi tse ling

Vitamin K Antagonists: ho qala kalafo ea rosuvastatin kapa ho eketsa tekanyetso ea rosuvastatin ho bakuli ba fumanang li-antagonists tsa vitamini K ka nako e le 'ngoe (mohlala, warfarin kapa li-anticoagulants tse ling tsa coumarin) li ka lebisa ho eketseha ha INR. Ho hlakoloa kapa ho fokotsoa ha tekanyetso ea Rosucard ® ho ka baka ho fokotseha ha INR. Maemong a joalo, ho khothalletsoa taolo ea INR.

Mekhoa ea ho thibela pelehi / ea molomo:ts'ebeliso e ts'oanang ea rosuvastatin le lithibela-pelehi tsa molomo li eketsa AUC ea ethinyl estradiol le AUC ea Norchedrel ka 26% le 34%, ka ho latellana. Keketseho e joalo ea khatello ea plasma e lokela ho tsotelloa ha ho khethoa lethal dose ea lithibela-pelehi tsa molomo.

Ha ho na datha ea pharmacokinetic mabapi le ts'ebeliso e le 'ngoe ea rosuvastatin le kalafo ea phetisetso ea li-hormone. Matla a tšoanang a ke ke a qheleloa ka thoko ka nako e le ngoe ts'ebeliso ea kalafo ea rosuvastatin le ea hormone. Leha ho le joalo, motsoako ona o ne o sebelisoa haholo nakong ea liteko tsa bongaka mme o ne o mamelleha hantle ke bakuli.

Meriana e meng: ha ho na ts'ebelisano e kholo ea rosuvastatin ka digoxin e lebelletsoeng.

Pharmacodynamics le pharmacokinetics

Rosucard ke ea sehlopha li-statins. E thibela HMG-CoA reductase - enzyme e fetolang GMG-CoA ka mellonate.

Ntle le moo, sesebelisoa sena se eketsa palo ea Li-receptors tsa LDL bulela hepatocytesseo se phahamisa botebo ba catabolism le ho ts'oaroa LDL mme e etsa hore ho se be le letho VLDLho fokotsa litaba tse akaretsang VLDL le LDL. Moriana o fokotsa khatello ea kelello HS-LDL, high density non-lipoprotein cholesterol, HS-VLDLP, TG, apolipoprotein B, TG-VLDLP, kakaretso xc, hape e eketsa litaba ApoA-1 le HS-HDL. Ntle le moo, e fokotsa sekhahla ApoVle ApoA-1, HS-eo e seng HDL le HS-HDL, HS-LDL le HS-HDL, kakaretso xc le HS-HDL.

Phello e ka sehloohong ea Rosucard e lekana hantle le tekanyetso e boletsoeng. Tšusumetso ea kalafo kamora ho qala kalafo e bonahala kamora beke, kamora nako e ka bang khoeli e ba ngata, ebe ea matlafala 'me e ba ea ka ho sa feleng.

Palo e phahameng ea ntho ea mantlha e sebetsang ka plasma e thehiloe kamora lihora tse 5. Ehlile bioavailability e etsa 20%. Tekanyo ea likhokahanyo le liprotheine tsa plasma ea mali e ka bang 90%.

Ka tšebeliso ea kamehla, li-pharmacokinetics ha li fetohe.

E etselitsoe Rosucard ka har'a sebete. E kenella hantle tšitiso ea placental. Ka sehloohong metabolites – N-dismethyl le lactone metabolites.

Bophelo ba halofo ke hoo e ka bang lihora tse 19, ha bo sa fetohe haeba litekanyetso tsa moriana li eketsoa. Tlhahiso ea Plasma ka karolelano - 50 l / h. Hoo e ka bang karolo ea 90% ea ntho e sebetsang e epuoa ka popelong e sa fetoha, tse ling kaofela ka liphio.

Ho kopanela liphate le lilemo ha li ame li-pharmacokinetics tsa Rosucard. Leha ho le joalo, ho latela morabe. Maindia a na le khatello e phahameng le kakaretso Auc Makhetlo a 1,3 a phahame ho feta a lebelo la Caucasus. Aucbathong ba morabe oa Mongoloid, makhetlo a 2 ho feta.

Matšoao a sebelisang Rosucard

Matšoao a ts'ebeliso ea Rosucard ke a latelang:

• hypercholesterolemia ea mantlha kapa e kopane dyslipidemia - sethethefatsi se sebelisoa e le tlatsetso ea lijo haeba phepo e nepahetseng ea phepo e le ngoe e sa lekana,
• tlhoko ea ho lieha ho hola atherosulinosis - moriana o sebelisoa e le tlatsetso ea ho ja e le karolo ea kalafo ho fokotsa maemo k'holeseterole e felletseng le Cholesterol ho litefiso tse tloaelehileng
• lelapa homozygous hypercholesterolemia - sethethefatsi se sebelisoa e le tlatsetso ho lijo kapa e le motsoako lipid li fokotseha kalafo
• tlhokeho ea thibelo ea mathata maemong a ts'ebetso ea methapo ea pelo le kotsi ea ho hlahaatherosulinotic lefu la pelo - lithethefatsi li sebelisoa e le karolo ea kalafo.

Litlamorao

Litlamorao tse mpe tse ka bakoang ke tšebeliso ea lithethefatsi e ka ba tse latelang:

• tsamaiso ea methapo: hlooho e bohloko, asthenic syndrome, ho tsekela,
• tsamaiso ea phefumoloho: khohlela, dyspnea,
• tsamaiso ea musculoskeletal: myalgia,
• letlalo le lisele tse nyane: edema ea peripheral, Stevens-Johnson syndrome,
• matšoao a laboratori: Keketseho ea nakoana ea tšebetso serum CPK ho latela tekanyetso
• karabelo: ho hlohlona, urticariamakhopho
• tsamaiso ea tšilo ea lijo: ho nyekeloa ke pelo, bohloko ka mpeng, ho sokelaho hlatsa lets'ollo,
• tsamaiso ea endocrine: mofuta II lefu la tsoekere,
• Sisteme sa urine: proteinuriats'oaetso ea pampitšana ea urinary.

Maemong a sa tloaelehang, ho ka etsahala peripheral neuropathy, pancreatitisho senyeha hoa mohopolohepatitis, jaundice, myopathy, rhabdomyolysis, angioedema, hematuria, ea nakoana eketsa Ts'ebetso ea AST le ALT.

Tšebelisano

Cyclosporin hammoho le rosucard e eketsa boleng ba eona Auc ka makhetlo a 7. Ho nka tse fetang 5 mg ha ho kgothaletswe.

Gemfibrozille ba bang lipid-lowing meriana e kopaneng le rosucard e baka keketseho ea khatello ea eona e phahameng le Auc hoo e ka bang habeli. Kotsi ea myopathies. Tekanyetso e phahameng ha e kopantsoe le Gemfibrozil - 20 mg. Ha o sebetsana le fibrate litekanyetso tsa moriana ho 40 mg ha lia lumelloa, tekanyetso ea pele ke 5 mg.

Ho sebelisana le lithethefatsi le proteinase inhibitors e kanna ea eketseha tlhahiso Rosuvastatin. Ts'ebeliso ea motsoako ona ha e khothalletsoe Tšoaetso ea HIV ho bakuli.

Ho kopana Erythromycin le rosucard ea fokotsa Auctsa morao-rao ke tse 20%, 'me tse phahameng ka ho fetisisa ke tse 30%.

Ha u kopanya sethethefatsi sena le Lopinavir le ritonavir e eketsa ho lekana ha eona Auc le mahloriso a mangata.

Li-antagonists tsa Vitamin K ha o sebelisana le rosucard etsa hore ho be le keketseho likamano tse tloaelehileng tsa machabeng.

Ezetimibe ka nako e tšoanang le rosuvastatin e ka baka litlamorao.

Antacid meriana e nang le aluminium hydroxide kapa magnesium e fokotsa palo ea lithethefatsi 'meleng ka halofo. Kahoo lipakeng tsa kamohelo ea bona o hloka ho nka phomolo bonyane lihora tse peli.

Ha u kopanya Rosucard le kemolo ea molomo ho bolela ho hloka ho laola maemo a bakuli.

Litlhahlobo mabapi le Rosucard

Litlhahlobo mabapi le Rosucard li ntle haholo. Hangata sesebelisoa sena se eletsoa ke lingaka. E theko e tlaase, kahoo ho e reka ho hlakile. Ba seng ba ntse ba sebelisitse kalafo ena ba tlohela ho sebelisa lithethefatsi mabapi le Rosucard, moo ho tlalehiloeng hore moriana o ba thusitse ho boloka cholesterol e tloaelehileng le ho emisa tsoelo-pele ea lefu lena.

Theko ea Rosucard

Theko ea Rosucard e nkoa e theko e tlaase haholo ha e bapisoa le li-analogues tse ngata. Litsenyehelo tse tobileng tsa moriana li ipapisitse le litaba tsa ntho e sebetsang matlapeng. Kahoo, theko ea rosucard ea 10 mg ka har'a sephutheloana se nang le lipoleiti tse 3 ke li-ruble tse 500 ho la Russia kapa li-h hpnias tse 100 tsa Ukraine. 'Me theko ea Rosucard 20 mg ka sephutheloaneng se nang le lipoleiti tse 3 ke li-ruble tse 640 Russia kapa li-h hpnias tse 150 ho la Ukraine.

Melemo ea pharmacological

Karolo e sebetsang ho lokiso ea Rosucard, rosuvastatin, e na le thepa ea ho thibela tšebetso hape e fokotsa phapang ea limolek'hule tsa mevalonate, tse ikarabellang bakeng sa tlhaiso ea cholesterol mehatong ea pele liseleng tsa sebete.

Motsoako ona o na le phello e matlafatsang ea ho phekola lipoprotein, o fokotsa metsoako ea tsona ka lisele tsa sebete, tse fokotsang haholo li-lipoprotein tsa boima ba limolek'hule le ho eketsa bongata ba lipoprotein tse phahameng tsa limolek'hule.

Pharmacokinetics ea sethethefatsi Rosucard:

• Khokahano e phahameng ka ho fetisisa ea likarolo tse sebetsang motsoakong oa plasma ea mali, kamora ho nka matlapa, e etsahala kamora lihora tse 5,
• The bioavailability ea lithethefatsi ke 20.0%,
• Ho pepesetsoa ha Rosucard tsamaisong ho ipapisitse le litekanyetso tse eketsehileng
• 90.0% ea meriana ea Rosucard e tlama liprotheine tsa plasma, hangata, ke protheine ea albin,
• Motsoako oa lithethefatsi tse liseleng tsa sebete maemong a pele ke hoo e ka bang 10,0%,
• Bakeng sa cytochrome isoenzyme No. P450, motsoako o sebetsang oa rosuvastatin ke substrate,
• Lithethefatsi li hlahisoa ke 90.0% ka makhopho, 'me lisele tsa mala li ikarabella bakeng sa ona,
• 10.0 e qhekelloa ho sebelisa lisele tsa liphio ka moroto,
• The pharmacokinetics ea lithethefatsi Rosucard ha ea itšetleha ka sehlopha sa bakuli, hammoho le bong. Moriana o sebetsa ka tsela e lekanang, 'meleng oa motho e monyane le ho batho ba baholo, ke botsofaling feela moo ho lokelang ho ba le tekanyetso e fokolang ea kalafo ea index ea cholesterol e phahameng maling.

Litlamorao tsa kalafo ea lithethefatsi tsa sehlopha sa Rosacard tsa li-statins li ka utluoa kamora ho nka moriana matsatsi a 7. Phello e phahameng ea phekolo e ka bonoa kamora ho nka pilisi matsatsi a 14.

Litsenyehelo tsa moriana oa Rosucard li itšetlehile ka moetsi oa sethethefatsi, e leng naha eo moriana o entsoeng ho eona. Lingoloa tsa Russia tsa lithethefatsi li theko e tlaase, empa phello ea lithethefatsi ha e ea itšetleha ka theko ea sethethefatsi.

Analogue ea Russia ea Rosucard, ka tsela e atlehileng e fokotsa index ho cholesterol ea mali, le meriana ea kantle ho naha.

Theko ea Rosucard ea lithethefatsi ho la Russian Federation:

• Theko ea rosucard 10,0 mg (matlapa a 30) - li-ruble tse 550,00,
• Motsoako Rosucard 10,0 mg (li-pcs tse 90.) - 1540.00 li-ruble,
• Motsoako oa mantlha Rosucard 20,0 mg. (Tab ya 30.) - li-ruble tse 860.00.

Bophelo ba sehatsetsing le tšebeliso ea matlapa a Rosucard ke selemo se le seng ho tloha mohla ba lokolloang. Kamora letsatsi la ho felloa ke matla, ho molemo ho se sebelise sethethefatsi.

Litheko tsa Rosucard ka litlhare tsa meriana tsa Moscow

lipilisi	10 mg	Li-pcs tse 30	≈ 625 rub.
	10 mg	Likhomphutha tse 60.	≈ 1070 rub.
	10 mg	Li-pcs tse 90.	≈ 1468 rub.
	20 mg	Li-pcs tse 30	≈ 918 rub.
	20 mg	Likhomphutha tse 60.	≈ 1570 rub.
	20 mg	Li-pcs tse 90.	Rub 2194.5 rub.
	40 mg	Li-pcs tse 30	≈ 1125 rub.
	40 mg	Li-pcs tse 90.	≈ 2824 rub.

Lingaka li hlahloba mabapi le rosacea

Tekanyetso 3.3 / 5

Ho sebetsa hantle

Theko / boleng

Litlamorao

Analogue e ntle haholo ea tšimoloho ea Czech, e entsoeng ka thepa ea boleng bo phahameng ea lihlahisoa tse phahameng, e bontšitse phello e ntle haholo ea kliniki.

Ha e le molao, rosuvastatin ha e amohelehe bakeng sa litheko, mme nyeoe ena ha e khetholloe, ka bomalimabe.

Setlhare se hlile sea sebetsa, se sebetsa feela kamora ho buisana le setsebi.

Tekanyetso 3.8 / 5

Ho sebetsa hantle

Theko / boleng

Litlamorao

O leboha ts'ebetso ea sethethefatsi sena sa mofuta - e tloaetse metabolism ea lipid hantle ka mathata a manyane le lits'ebetso tse seng tsa semorabe, le ho feta - sena ke theko, ha se bapisoa le sefapano.

Ho na le litla-morao, empa e sa bonoe haholo, hobane ke e beha khafetsa ka litlolo tse nyane - litekanyetso tsa bonyane 5-10 mg.

Tekanyetso 2,5 / 5

Ho sebetsa hantle

Theko / boleng

Litlamorao

Mabapi le phihlello: li-statin ha se lithethefatsi tse theko e tlaase. Empa li har'a lingaka tse 'maloa tse pholosang bophelo e le kannete. Ehlile, ka lehaha - pholosa bophelo ba ba nang le mafu a amanang le atherosclerosis - myocardial infarction, angina pectoris, atherosulinosis ea methapo ea methapo e tlaase. Haeba statin e bitsa li-ruble tse 100-200, ke tšaba ho fana ka eona.

Li-generics tse ngata (likopi tse hlahisitsoeng hape) tsa li-statins, empa, ehlile, ha se tsohle tse sebetsang hantle ka ho lekana. Ngaka e ikarabellang e tla fana ka li-jenereithara feela tseo ho nang le datha e ntle ho tsoa lithutong mabapi le kalafo e tšoanang le moriana oa mantlha (molemong oa rona, ke sefapano). Basebetsi ba litlama litabeng tsena, e le molao, ha ba shebelle ho hang mme ba ba botsa ka "mehopolo" efe kapa efe, hammoho le ho sebelisa litlhahiso tsa bona ka "litlatsetso", ke tsela ea ho soetseha ka kalafo.

Tlhahlobo ea mokuli ea Rosucard

Ha ke tsebe hore na ha e hlahise litla-morao tsa hau ho ba lelapa la hau. Rosucard e makatsa feela. 'Na le monna oa ka hang ka mor'a ho sebelisa moriana ona re qalile ho ts'oaroa ke lets'ollo, nakoana kamora moo, ho hlobaela le maemo a makatsang a pelo e hokahaneng Ka hona, joale re tla etsa qeto le ngaka ka bokamoso ba kamohelo ea hae.

Ke rekile Rosucard ka li-ruble tse 508. Ke noetse khoeli kamora letsatsi, k'holeseterole e fokotsehile ho tloha ho 7 ho isa ho 4,6. Ha kea ka ka noa 'me ka mor'a likhoeli tse peli hape 6.8. Ke ile ka hana ka nako e telele, empa ke ile ka nka qeto: Ke tla noa. Ke lekile litlama tse fapaneng, ho nwa atherocliphite, ha e na phello.

"Theko e theko e tlase haholo" - 900 re (!?) Sena se ka theko e tlase. Kea utloisisa hore mona u bona batho ba limilione ba limilione ba ntse ba alafshoa.

Rosucard ke sethethefatsi se setle. Ke ile ka khetha ngaka ea ka ho nkhono oa ka hore a e thibele. Moriana o bontšitse phello kamora khoeli e ka bang 1 ea tšebeliso. Molemong oa rona, ho bohlokoa hore rosucard e ka nooa le meriana e meng. O ne a ikutloa a le betere, 'me ka holim'a tsohle, ho ne ho se na litla-morao. Ha rea ​​ka ra hlokomela mefokolo leha e le efe.

Ntate-moholo (ea lilemo li 72) o bile le mathata a pelo ka lilemo tse leshome, mohlomong. Mabapi le ho putlama, re ile ho setsebi sa pelo, se ileng sa re eletsa hore re qale ho nka rosacea. Theko e theko e tlaase, re ntse re e noella khoeling ea boraro. Ha u le tseleng, mokhoeng oa taolo oa mali, cholesterol e fokotsehile haholo. Re thabile ka lebaka la rosacea!

Tlhaloso e khutšoane

Rosucard (motsoako o sebetsang - rosuvastatin) - sethethefatsi se fokotsang lipid sehlopheng sa li-statins. Kajeno, ba ka bang 80-95% ea bakuli ba nang le lefu la pelo (haeba re nka linaha tse tsoetseng pele) ba nka lits'oants'o. Ho tuma ho pharaletseng hakana ha sehlopha sena sa lithethefatsi ho bontša ho ts'epa e felletseng ho eona ke lingaka tsa lefu la pelo, tse lokelang ho nkuoa li nepahetse ka ho felletseng: lilemong tsa morao tjena, liphetho tsa liteko tse kholo tse 'maloa tsa kliniki li hlahisitsoe lekhotleng la sechaba sa bongaka, ho tiisa ho fokotseha hoa lefu la pelo nakong ea kalafo ka li-statins. Ntle le moo, litlamorao tse ling tsa lithethefatsi tsena, tse ikemiselitseng ka botlalo, li ile tsa senoloa: mohlala, ts'ebetso ea bona ea anti-ischemic. 'Me phello e khahlanong le ho ruruha ea li-statins e tsebahala hoo lingaka tse ling li seng li ntse li leka ho phekola ramatiki ka ramatiki. Rosucard ke sethethefatsi se entsoeng ka botlalo se tsoang sehlopheng sa li-statin, se amohetsoeng ho sebelisoa mathoasong a 2000s a lekholo le fetileng la lilemo. Leha tlholisano e tsoa ho li-statins tse ling tse hlano 'marakeng oa litlhare kajeno, rosucard ke e' ngoe ea lithethefatsi tse atileng haholo (haeba e se tsona tse tsebahalang) sehlopheng sena ho latela matla a kholo a palo ea litaelo tsa bongaka. Kamora ho sebelisa tekanyetso e le 'ngoe ea moriana, tlhoro ea eona ea plasma e bonoa kamora lihora tse ka bang 5. Rosucard e phela nako e telele ka ho fetisisa ea lihora tse 19. Melemo ea pharmacokinetic ea lithethefatsi ha e amehe ka lintlha tse kang lilemo, bong, tekanyo ea botlalo ba mala, boteng ba ho hloleha ha sebete (ntle le mefuta ea eona e matla). Molek'hule ea rosuvastatin - ntho e sebetsang ea lithethefatsi - ke hydrophilic, e bakang phello ea eona e ka tlase ho kenyelletso ea k'holeseterole liseleng tsa mesifa ea mesifa ea marapo. Ka lebaka la sena, rosucard ha e hlahisoe litla-morao tse hlahang ho li-statins tse ling. Monyetla o mong oa lithethefatsi holim'a "basebetsi-'moho" sehlopheng sa pharmacological (haholo-holo ka atorvastatin le simvastatin) ke hore ha e sebetsane le li-enzyme tsa sistimi ea cytochrome P450, e lumellang rosucard hore e be teng hammoho le lithethefatsi tse ling tse ngata (li-anti-antihistamines, lithethefatsi tsa antiulcer, li-antifungal agents, jj.

e.) ntle le kotsi ea ts'ebelisano ea bona e sa batleheng. Bohlokoa ba rosuvastatin (rosucard) bo ithutile mme bo ntse bo ithutoa litekong tse ngata tsa kliniki. Palo ea lithuto tse phethiloeng ho tla fihlela joale, Phuputso ea MERCURY, e bonts'itseng monyetla o moholo oa lithethefatsi tsena holim'a li-statins tse ling ka phello ea eona profil ea profid, e ratoa haholo. Lenane la sepheo sa k'holeseterole e "mpe" (LDL) ha u nka rosucard e fihlelitsoe ho bakuli ba 85% (ba sebelisa lethalamo le tšoanang la atorvastatin le fane ka sephetho se lakatsehang ho 80% feela. Ka nako e ts'oanang, boemo ba "cholesterol" e ntle "(HDL) e ne e phahame haholo ho feta ha o sebelisa atorvastatin. Ho fokotsa khatello ea likaroloana tsa cholesterol ea atherogenic (haholo-holo LDL) hase eona feela sepheo sa phekolo e fokotsang lipid. E boetse e lokela ho ikemisetsa ho eketsa litaba tsa karolo ea antiatherogenic ea lipoprotein tsa HDL, boemo boo, joalo ka molao, bo fokotsehileng. Mme rosucard e sebetsana ka katleho le sena: ts'ebetsong ea eona ea sebopeho sa lipoproteins, e boetse e feta simvastatin le pravastatin. Ho fihla joale, moriana o khothalletsoa ho nooa ka tekanyetso ea 10-40 mg ka letsatsi.

Tšireletseho ea kalafo ha e bohlokoa joaloka eona ho feta polokeho, haholo-holo haeba moriana o etselitsoe bakuli ba bangata haholo. Ho shebana haholo le litaba tsa polokeho ea statin ho fanoe ke boemo ke cerivastatin, e neng e tlosoa 'marakeng ka lebaka la palo e kholo ea litla-morao. Mabapi le sena, rosuvastatin (rosucard) e entse patlisiso e thata ho latela profil ea eona ea polokeho. 'Me, joalo ka ha ho netefalitsoe nakong ea liteko tsa tleliniki, kotsi ea litlamorao ha ho nooa moriana (ho latela tekanyetso e khothalletsoang) ha e phahame ho feta li-statins tse sebelisoang hona joale.

Thutela-litso

Hypolipidemic lithethefatsi ho tsoa sehlopheng sa li-statins. Inhibitor e khethiloeng ea HMG-CoA reductase, enzyme e fetolang HMG-CoA ho mevalonate, moetapele oa k'holeseterole (Ch).

E eketsa palo ea li-receptor tsa LDL holim'a li-hepatocytes, tse lebisang ho ho eketseha le ho ts'oaroa ha LDL, thibelo ea motsoako oa VLDL, ho fokotsa kakaretso ea LDL le VLDL. E fokotsa mokokotlo oa LDL-C, HDL cholesterol-non-lipoproteins (HDL-non-HDL), HDL-V, cholesterol e felletseng, TG, TG-VLDL, apolipoprotein B (ApoV), e fokotsa karolelano ea LDL-C / LDL-C, kakaretso - HDL, Chs-eseng HDL / Chs-HDL, ApoV / apolipoprotein A-1 (ApoA-1), e eketsa khatello ea chs-HDL le ApoA-1.

Phello ea ho fokotsa lipid e lekana ka kotloloho le tekanyo ea tekanyo e boletsoeng. Phello ea kalafo e hlahella ka hara beke 1 kamora ho qala kalafo, kamora libeke tse peli e fihla ho 90% ea boholo, e fihla hofihlella ka libeke tse 4 ebe e lula e le joalo. Setlhare sena se sebetsa hantle ho bakuli ba baholo ba nang le hypercholesterolemia e nang le hypertriglyceridemia (ho sa tsotelehe hore na ke ba morabe ofe, bong kapa lilemo). ho bakuli ba nang le lefu la tsoekere mellitus le hypercholesterolemia ea malapa. Ho 80% ea bakuli ba nang le mofuta oa IIa le IIb hypercholesterolemia (phapanyetsano ea Fredrickson) ka karolelano ea khatello ea mantlha ea LDL-C e ka bang 4,8 mmol / L, ha ba ntse ba sebelisa moriana ka tekanyo ea 10 mg, mahloriso a LDL-C a fihla tlase ho 3 mmol / L. Bakeng sa bakuli ba nang le homozygous Familyal hypercholesterolemia ba fumanang lithethefatsi ka tekanyetso ea 20 mg le 40 mg, ho fokotseha ho tloaelehileng ha khatello ea LDL-C ke 22%.

Phello ea tlatsetso e bonoa hammoho le fenofibrate (mabapi le ho fokotseha ha mahloriso a TG le nicotinic acid ho litekanyetso tse theolang lipid (eseng tlase ho 1 g / letsatsi) (mabapi le ho fokotseha ha mahloriso a HDL-C).

U ka nka rosucard joang?

Rosucard ea lithethefatsi e lokela ho nooa ka molomo ka metsi a lekaneng. Ho hlafuna letlapa ha lea lumelloa, hobane le koahetsoe ka membrane e qhibilihang mala.

Pele o qala thupelo ea kalafo ka kalafo ea Rosucard, mokuli o tlameha ho latela mokhoa oa ho ja oa anticholesterol, 'me lijo li tlameha ho tsamaea le tsela eohle ea kalafo ka li-statins, ho latela motsoako o sebetsang - rosuvastatin.

Ngaka ka boeona e khetha moriana ho mokuli ka mong, ho latela liphetho tsa liteko tsa laboratori, hammoho le mamello ea 'mele oa motho ka mong.

Ke ngaka feela, haeba ho hlokahala, e tsebang ho kenya matlapa a Rosucard. Phetoho ea moriana le motsoako oa moriana o mong le motsoala o mong ha e fihle ho feta libeke tse peli ho tloha nakong ea tsamaiso.

Litekanyetso tsa pele tsa moriana oa Rosucard ha lia lokela ho ba holimo ho li-milligram tse 10,0 hang ka letsatsi.

Butle-butle, nakong ea phekolo, haeba ho hlokahala, nakong ea matsatsi a 30, ngaka e etsa qeto ea ho eketsa tekanyetso.

Bakeng sa ho eketsa tekanyetso ea letsatsi le letsatsi ea moriana oa Rosucard, ho hlokahala mabaka a latelang:

• Mofuta o matla oa hypercholesterolemia, e hlokang litekanyetso tse phahameng tsa li-milligram tsa 40.0,
• Haeba ho litekanyetso li-milligram tse 10,0, lipilone e bontšitse ho fokotseha ha cholesterol. Ngaka e eketsa litekanyetso tsa li-milligram tse 20,0, kapa hang-hang lethal dose.
• Ka mathata a tebileng a ho hloleha ha pelo,
• Ka mohato o tsoetseng pele oa pathology, atherosclerosis.

Bakuli ba bang, pele ba eketsa tekanyetso, ba hloka maemo a ikhethang:

• Haeba matšoao a lefu la lisele tsa sebete a tsamaisana le lintlha tsa 7.0 tsa bana, ho eketsa tekanyetso ea Rosucard ha ho kgothaletsoe.
• Maemong a ho hloleha ha menoana, o ka qala sehlopha sa lithethefatsi ka matlapa a 0.5 ka letsatsi, 'me ka mor'a moo o ka eketsa litekanyetso ho li-milligram tse 20,0, kapa esita le ho tekanyetso e phahameng.
• Ho hloleha ho matla ha a liphio, "li-statins" ha li lumelloe,
• Botebo bo leka-lekaneng ba ho se sebetse hantle ha renal. Tekanyetso e phahameng ea meriana ea Rosucard ha e laeloe ke lingaka,
• Haeba ho na le kotsi ea lefu la tsoekere, myopathy le eona e hloka ho qala ka matlapa a 0.5 mme lethal dose ea 40.0 milligrams le thibetsoe.

Ntlafatsa litekanyetso nakong ea kalafoho litaba tse kahare ↑

Qeto

Motsoako oa Rosucard o ka sebelisoa kalafo ea k'holeseterole e phahameng maling, o kopantsoe feela le phepo e ntle ea anticholesterol.

Ho sitoa ho latela lijo ho tla liehisa ts'ebetso ea ho folisa le ho mpefatsa litlamorao tse mpe tsa sethethefatsi 'meleng.

Rosucard ea lithethefatsi e ke ke ea sebelisoa e le mokhoa oa ho iphekola, 'me ha ho fanoa ka taelo, ha hoa lumelloa ho fetola litekanyetso tsa matlapa, hammoho le ho fetola mofuta oa kalafo.

Yuri ea lilemo li 50, Kaliningrad: li-statins li theole cholesterol ea ka ho tloaelehileng ka libeke tse tharo. Empa kamora moo, index e ile ea phahama hape, mme ke ile ka tlameha ho nka tsela ea kalafo ka lipilisi tsa statin hape.

Ke feela ha ngaka e fetolela moriana oa ka oa pele ho Rosucard, ke ileng ka hlokomela hore lipilisi tsena li ka se khutlisetse cholesterol ea ka ho tloaelehileng, empa hape li sa e eketse haholo kamora ts'ebetso ea kalafo.

Natalia, ea lilemo tse 57, Ekaterinburg: cholesterol e ile ea qala ho phahama nakong ea ho khaotsa ho ilela khoeli, mme phepo e sa khone ho e theola. Ke se ke qetile lilemo tse peli ke sebelisa lithethefatsi tse thehiloeng rosuvastatin. Likhoeling tse 3 tse fetileng, ngaka e ile ea nkela sethethefatsi sa ka sa pele le matlapa a Rosucard.

Ke ile ka utloa phello ea eona hanghang - Ke ile ka ikutloa ke le betere mme ke maketse hore ebe ke khona ho theola li-kilos tse 4 tsa boima bo feteletseng.

Nesterenko N.A., ngaka ea pelo, Novosibirsk - Ke fana ka li-statin ho bakuli ba ka ha mekhoa eohle ea ho fokotsa cholesterol e se e lekile mme ho na le kotsi e kholo ea ho nts'etsapele lefu la cardio, hammoho le atherosclerosis.

Statins e na le litla-morao tse ngata 'meleng, tse amang boleng ba bophelo ba bakuli.

Empa ka ho sebelisa moriana oa Rosucard ts'ebetsong ea ka, ke hlokometse hore bakuli ba emisitse ho tletleba ka litlamorao tse mpe tsa li-statins. Ho lumellana le litlhahiso tsohle bakeng sa tšebeliso ho tla fa mokuli tekanyo e fokolang ea ho fetoha ha 'mele.