Liptonorm: litaelo tsa tšebeliso, analogues, theko, litekolo

Nomoro ea ngoliso: P No. 016155/01

Khoebo lebitso la lithethefatsi: Liptonorm®

Lebitso le sa Tšoaneleheng Kantle ho Naha: Atorvastatin

Foromo ea litekanyetso: matlapa a koahetsoeng

Sebopeho

Letlapa le leng le le leng le koahetsoeng le na le:
Ntho e sebetsang - calcium ea Atorvastatin, ka tekanyo e lekanang le 10 mg le 20 mg ea atorvastatin
Baeti: calcium carbonate, cellulose ea microcrystalline, lactose, 80, hydroxypropyl cellulose, crossscarmellose, magnesium stearate, hydroxypropyl methyl cellulose, titanium diode, polyethylene glycol.

Tlhaloso

Matlapa a koahetsoeng ka filimi e tšoeu, e chitja, e biconvex. Nakong ea khefu, matlapa a tšoeu kapa a batla a soeufetse.

Sehlopha sa Pharmacotherapeutic: moemeli ea fokotsang lipid - inhibitor ea HMG CoA reductase.

ATX CODE S10AA05

Melemo ea pharmacological

Pharadodynamics
Hypolipidemic moemeli ea tsoang sehlopheng sa li-statins. Mochine o ka sehloohong oa ts'ebetso ea atorvastatin ke ho thibela ts'ebetso ea 3-hydroxy-3-methylglutaryl coenzyme A - (HMG-CoA) reductase, enzyme e thusang ho fetoloa ha HMG-CoA ho mevalonic acid. Phetoho ena ke e meng ea mehato ea pele ho ketane ea kholeseterole ea 'mele. Ho hatelloa ha atorvastatin cholesterol synthesis ho lebisa ho ho eketseha hape ha li-receptor tsa LDL (lipalo tse fokolang tsa methapo ea methapo) ho sebete, hammoho le liseleng tse eketsehileng. Li-receptor tsena li tlama likaroloana tsa LDL le ho li tlosa plasma ea mali, e lebisang ho cholesterol ea LDL e tlase maling.
Matla a antisulinotic a atorvastatin ke litholoana tsa litlamorao marang-rang a methapo ea mali le likarolo tsa mali. Lithethefatsi li thibela motsoako oa isoprenoids, e leng lintlha tsa kholo tsa lisele tse kahare tsa methapo ea mali. Tlas'a tšusumetso ea atorvastatin, ho atoloha ho itšetlehileng ka methapo ea methapo ea mali hoa ntlafala. Atorvastatin lowers cholesterol, lipensiprotein tse tlase, apolipoprotein B, triglycerides. Ho baka keketseho ea cholesterol ea HDL (diploprotein tse phahameng) le apolipoprotein A.
Ketso ea moriana, joalo ka molao, e tsoela pele kamora libeke tse peli tsa tsamaiso, mme phello e phahameng e fihlella kamora libeke tse 'ne.

Mofumahali
Ho chona ho phahameng. Nako ea ho fihlela khatello e phahameng ke lihora tse 1-2, boholo bo phahameng ba basali bo phahame ka 20%, AUC (sebaka se ka tlas'a khefu) e tlase ka 10%, palo e phahameng ea bakuli ba nang le cirrhosis ea lino tse tahang e makhetlo a 16, AUC e makhetlo a 11 ho feta e tloaelehileng. Lijo li theola sekhahla le nako ea ho amoheloa ha moriana (ka 25% le 9%, ka ho latellana), empa ho fokotseha ha cholesterol ea LDL ho tšoana le ts'ebeliso ea atorvastatin ntle le lijo. Keketseho ea atorvastatin ha e sebelisoa mantsiboea e tlase ho feta hoseng (hoo e ka bang 30%). Kamano ea linear pakeng tsa tekanyo ea ho amoheloa le lethalinyana la lithethefatsi e ile ea senoloa.
Bioavailability - 14%, systemic bioavailability ea mesebetsi e thibelang khahlanong le HMG-CoA reductase - 30%. Bioavailability e tlase e bakoa ke metabolism ea "presystemic metabolism" mucous membrane ea "gastrointestinal" le "nakong ea" karolo ea pele "ka sebete.
Bophahamo bo boholo ba kabo ke 381 l, khokahano le liprotheine tsa mali tsa mali ke 98%.
E tšelisoa haholo-holo ka har'a sebete tlas'a ts'ebetso ea cytochrome P450 CYP3A4, CYP3A5 le CYP3A7 ka ho thehoa ha li-metabolites tse sebetsang tsa li-metabolic (li-ortho- le para-hydroxylated, lihlahisoa tsa beta-oxidation).
Phello ea inhibitory ea lithethefatsi khahlanong le HMG-CoA reductase e batla e le 70% e khethiloeng ke ts'ebetso ea potoloho ea metabolites.
E pepesitsoe ka har'a bile ka mor'a hore e sebelisoe ka hepatic le / kapa metabolism e eketsehileng (ha e ts'oaroe ka mokhoa o matla).
Bophelo ba halofo ke lihora tse 14. Ts'ebetso ea inhibitory khahlanong le HMG-CoA reductase e phehella lihora tse ka bang 20-30, ka lebaka la ho ba teng ha metabolites e sebetsang. Ka tlase ho 2% ea tekanyetso ea molomo e behiloe ka har'a moroto.
Ha e qhekelloe nakong ea hemodialysis.

Matšoao a ho sebelisoa

Hypercholesterolemia ea mantlha, hyperlipidemia e kopantsoeng, heterozygous le homozygous Famer hypercholesterolemia (e le tlatsetso ho ja).

Hypersensitivity ho efe kapa efe ea likarolo tsa lithethefatsi, lefu la sebete sethaleng se sebetsang (ho kenyelletsa le hepatitis e sa foleng ea mali, hepatitis e sa foleng), ts'ebetso e eketsehang ea hepatic transaminase (makhetlo a fetang a 3 ha a bapisoa le moeli o kaholimo o tloaelehileng) oa tšimolohong, ho hloleha ha sebete (ho teba ha A le B ho ea ka Sisteme ea Ngoana-Pyug), lefu lena la methapo ea methapo, ho ima, ho nyekeloa, lilemo ho isa ho lilemo tse 18 (ho sebetsa hantle le polokeho ha li so theoe).

Ka tlhokomelo: nalane ea lefu la sebete, ho se leka-lekane ho matla ha electrolyte, mathata a endocrine le metabolic, botahoa, hypotension ea methapo, ts'oaetso e matla ea sethepu (sepsis), ho ts'oaroa ho sa laoleheng, ho buuoa ho hoholo, likotsi.

Tekanyetso le tsamaiso

Pele a qala kalafo ka Liptonorm, mokuli o lokela ho fetisetsoa lijong tse netefatsang ho fokotseha ha lipids tsa mali, tse lokelang ho shejoa nakong ea kalafo le moriana.
Ka hare, nka nako efe kapa efe ea letsatsi (empa ka nako e ts'oanang), ho sa tsotelehe lijo tse ngata.
Motsoako oa ho qala o khothalelitsoeng ke 10 mg hang ka letsatsi. Ka mor'a moo, lethal dose le khethoa ka bonngoe ho latela se hlokoang ke cholesterol - LDL. Tekanyetso e lokela ho fetoloa ka nako ea bonyane libeke tse 4. Sekhahla se phahameng sa letsatsi ke 80 mg ho lethal dose le le leng.

Hypercholesterolemia ea mantlha (heterozygous hereditary and polygenic) hypercholesterolemia (mofuta IIa) le hyperlipidemia (mofuta IIb) e tsoakiloeng
Phekolo e qala ka tekanyetso ea pele e khothalletsoang, e eketsoang kamora libeke tse 4 tsa kalafo, ho latela karabelo ea mokuli. Tekanyo e phahameng ea letsatsi le letsatsi ke 80 mg.

Homozygous hereditary hypercholesterolemia
Lenane la litekanyo le tšoana le mefuta e meng ea hyperlipidemia. Tekanyetso ea pele e khethoa ka bonngoe ho latela botebo ba lefu lena. Ho bakuli ba bangata ba nang le homozygous hereditary hypercholesterolemia, phello e nepahetseng e bonoa ha ho sebelisoa lithethefatsi ka tekanyetso ea letsatsi le letsatsi ea 80 mg (hang).

Bakeng sa bakuli ba nang le bothata ba ho phekoloa ka methapo le ho bakuli ba tsofetseng, ho lokisoa ha lethathamo la liptonorm ha ho hlokahale.
Bakeng sa bakuli ba nang le ts'ebetso ea sebete e sa sebetseng hantle, ho lokela ho sebelisoe tlhokomeliso mabapi le ho theoha ha moriana 'meleng. Litekanyetso tsa kliniki le tsa laboratori li lokela ho behoa leihlo ka hloko, 'me haeba liphetoho tse kholo tsa pathological li fumanoa, tekanyo e lokela ho fokotsoa kapa kalafo e lokela ho khaotsa.

Ho tsoa ho tsamaiso ea methapo e bohareng: maemong a fetang 2% - ho hloka boroko, ho tsekela, maemong a ka tlase ho 2% - hlooho ea hlooho, lefu la asthenic, malaise, ho otsela, ho lora bosiu, amnesia, ho tepella maikutlong, ho opeloa ke mokokotlo, sefahleho le khatello ea maikutlo. hypnothesia, ho lahleheloa ke kelello.
Ho tsoa linthong tsa kutlo: amblyopia, e lla litsebeng, ho omella ha conjunctiva, ho sitisoa ha bolulo, ho hema ka mahlong, ho se utloe, glaucoma, parosmia, tahlehelo ea tatso, ho feto-fetoha ha tatso.
Ho tsoa ho tsamaiso ea pelo le pelo: maemong a fetang 2% - bohloko ba sefuba, bo ka tlase ho 2% - palpitations, vasodilation, migraines, hypotension ea postural, khatello e phahameng ea mali, phlebitis, arrhythmia, angina pectoris.
Ho tsoa ho sheropoietic system: anemia, lymphadenopathy, thrombocytopenia.
Ho tsoa ts'ebetsong ea phefumoloho: maemong a fetang 2% - bronchitis, rhinitis, maemong a ka tlase ho 2% - pneumonia, dyspnea, asthma ea bronchial, nosebleeds.
Ho tsoa ts'ebetsong ea tšilo ea lijo: maemong a fetang 2% - ho nyekeloa ke pelo, ho opeloa ke pelo, ho ruruha kapa letšollo, ho ruruha, gastralgia, bohloko ba ka mpeng, ho ipolaisa tlala kapa takatso e matla ea molomo, molomo o omileng, ho luma, dysphagia, ho hlatsa, stomatitis, esophagitis, glossitis, ho ruruha le ho ruruha ha lera la mucous molomo, gastroenteritis, hepatitis, hepatic colic, cheilitis, duodenal ulcer, pancreatitis, cholestatic jaundice, ho sitisoa ke ts'ebetso ea sebete, ho tsoa mali ka mokokotlo, melena, letshollo la madi, tenese.
Ho tsoa ts'ebetsong ea musculoskeletal: maemong a fetang 2% - lefu la ramatiki, maemong a ka tlase ho 2% - maqhubu a leoto, bursitis, tendosynovitis, myositis, myopathy, arthralgia, myalgia, rhabdomyolysis, torticollis, hypertonicity ea mesifa, contractures e kopaneng.
Ho tsoa ts'ebetsong ea genitourinary: maemong a fetang 2% - ts'oaetso ea urogenital, edema ea morao-rao, maemong a ka tlase ho 2% - dysuria (ho kenyelletsa le polakiuria, nocturia, ho hlohlona ka urinary kapa ho boloka mokokotlo, ho ntša metsi ka mokokotlong), nephritis, hematuria, ho tsoa mali ka bosaling, nephrourolithiasis, metrorrhagia, pesidymitis, fokotseha libido, ho hloka matla, ho senyeha hoa kutlo.
Ka lehlakoreng la letlalo: ka tlase ho 2% ea linyeoe - alopecia, xeroderma, mofufutso o eketsehileng, eczema, seborrhea, ecchymosis, petechiae.
Litla-morao: maemong a ka tlase ho 2% - ho hlohlona, ​​lekhopho la letlalo, lefu la dermatitis, ka seoelo - urticaria, angioedema, edema ea sefahleho, photosensitivity, anaphylaxis, erythema multiforme, Stevens-Johnson syndrome, lefu le nang le chefo ea epidermal necrolysis (lefu la Lyell).
Matšoao a laboratori: ka tlase ho 2% ea linyeoe ke hyperglycemia, hypoglycemia, keketseho ea serum creatine phosphokinase, alkaline phosphatase, albinuria, keketseho ea alanine aminotransferase (ALT) kapa aspartic aminotransferase.
Tse ling: ka tlase ho 2% ea linyeoe - boima ba 'mele, gynecomastia, mastodynia, ho mpefala ha lefu la gout.

Bongata

Phekolo: ha ho na le litlhare tse tobileng. Phekolo ea matšoao e etsoa. Ba nka mehato ea ho boloka mesebetsi ea bohlokoa ea 'mele le mehato ea ho thibela ho amoheloa ha lithethefatsi ka ho fetesisa: ho kenella ka mpeng, ho ja mashala a entsoeng ka matla. Hemodialysis ha e na thuso.
Haeba ho na le matšoao le ho ba teng ha lintlha tsa kotsi bakeng sa nts'etsopele ea ho hloleha ha rerema ka lebaka la rhabdomyolysis (litla-morao tse sa tloaelehang empa tse matla), moriana o lokela ho khaotsa hanghang.
Kaha atorvastatin e amahanngoa haholo le protheine ea plasma, hemodialysis ke tsela e sa sebetseng ea ho tlosa ntho ena 'meleng.

Ho sebelisana le lithethefatsi tse ling

Ka tsamaiso e tšoanang ea cyclosporine, fibrate, erythromycin ,cacithromycin, immunosuppression, lithethefatsi tsa antifungal (tse amanang le azoles) le nicotinamide, mahloriso a atorvastatin ho plasma ea mali (le kotsi ea myopathy) ea eketseha. Li-antacids li fokotsa khatello ea maikutlo ka 35% (phello ea cholesterol ea LDL ha e fetohe).
Ts'ebeliso e kopanetsoeng ea atorvastatin e nang le li-inhibitors tsa CYP3A4 cytochrome P450 e tsamaisana le keketseho ea plasma ea atorvastatin.
Ha o sebelisa digoxin hammoho le atorvastatin ka tekanyo ea 80 mg / ka letsatsi, mahloriso a digoxin a eketseha ka hoo e ka bang 20%.
E eketsa khatello ea maikutlo ka 20% (ha e laetsoe le atorvastatin ka lethal dose ea 80 mg / letsatsi) ea lithibela-pelehi tsa molomo tse nang le norethindrone le ethinyl estradiol.
Phello e fokotsang lipid ea ho kopanya le colestipol e phahametse eo ho moriana ka mong.
Ka tsamaiso e tšoanang ka warfarin, nako ea prothrombin ea fokotseha matsatsing a pele, leha ho le joalo, kamora matsatsi a 15, letšoao lena le beha maemong. Tabeng ena, bakuli ba nkang atorvastatin e nang le warfarin ba lokela ho ba bonolo ho feta ho tloaelehileng ho laola nako ea prothrombin.
Ts'ebeliso ea lero la morara nakong ea kalafo le atorvastatin e ka lebisa ho eketseha ha khatello ea lithethefatsi ho plasma ea mali. Mabapi le sena, bakuli ba noang moriana ba lokela ho qoba ho noa lero lena.

Litaelo tse khethehileng

Ts'ebetso ea sebete e sa sebetseng
Ts'ebeliso ea li-inhibitors tsa HMG-CoA reductase ho fokotsa lipids tsa mali e ka lebisa phetohong ea liparamente tsa biochemical tse bonts'ang mosebetsi oa sebete.
Ts'ebetso ea sebete e lokela ho beoa leihlo pele ho kalafo, libeke tse 6, libeke tse 12 kamora ho qala Liptonorm le kamora ho eketseha ha lethal dose, mme nako le nako, mohlala, likhoeli tse ling le tse ling tse 6. Phetoho mosebetsing oa li-enzyme tsa sebete e atisa ho shejoa nakong ea likhoeli tse tharo tsa pele kamora ho qala ho nka Liptonorm. Bakuli ba nang le keketseho ea litekanyetso tsa transaminase ba lokela ho hlahlojoa ho fihlela maemo a enzyme a khutlela ho tloaelehileng. Ketsahalong eo boleng ba alanine aminotransferase (ALT) kapa aspartic aminotransferase (AST) bo fetang ka makhetlo a 3 tekanyo ea moeli o amohelehang o phahameng, ho khothalletsoa ho fokotsa tekanyetso ea Liptonorm kapa ho emisa kalafo.

Mesifa ea lesapo
Bakuli ba nang le diffuse myalgia, lethargy kapa bofokoli ba mesifa le / kapa keketseho e kholo ea KFK e emela sehlopha sa kotsi bakeng sa nts'etsopele ea myopathy (e hlalosoa e le bohloko ba mesifa ka keketseho e kopaneng ea KFK makhetlo a fetang 10 ha e bapisoa le moeli o holimo oa tloaelehileng).
Ha o fana ka litlhare tsa motsoako oa Liptonorm le cyclosporine, li-derivatives tsa fibric acid, erythromycin ,cacithromycin, immunosuppressants, le lithethefatsi tsa antifungal tsa sebopeho sa azole, hammoho le litekanyetso tsa niacin tse bakang ho fokotseha hoa lipid tsa lipid, ho bohlokoa ho bapisa melemo e ka bang teng le tekanyo ea kotsi le kalafo ena le bakuli. eo matšoao kapa matšoao a bohloko ba mesifa, mokhathala kapa bofokoli bo hlahang, haholo likhoeling tsa pele tsa kalafo le ka keketseho ea lethal dose la efe kapa efe Reparata.

Phekolo ea liptonorm e lokela ho emisoa ka nakoana kapa e emisoe ka lebaka la nts'etsopele ea boemo bo tebileng bo ka bakoang ke lefu la myopathy, hape le haeba ho na le mabaka a kotsi bakeng sa nts'etsopele ea ho hloleha ha reute haholo ka lebaka la rhabdomyolysis (mohlala, ts'oaetso e matla, ho ruruha haholo mathata a metabolic le endocrine, hammoho le ho se leka-lekane ha electrolyte).
Ho basali ba lilemo tsa ho ba le bana ba sa sebeliseng lithibela-pelehi tse tšepahalang, tšebeliso ea Liptonorm ha e khothalletsoe. Haeba mokuli a rera ho ima, o lokela ho emisa ho nka Liptonorm bonyane khoeli pele moimana o reriloeng.
Mokuli o lokela ho ea ngakeng hang-hang haeba ho ba le bohloko bo sa hlalosoang kapa bofokoli ba mesifa, haholo haeba bo tsamaisana le malaise le feberu.

Tšusumetso ho bokhoni ba ho khanna koloi le ho sebetsa ka mekhoa

Litlamorao tse bohloko tsa Liptonorm mabapi le bokhoni ba ho khanna koloi le ho sebetsa ka methati e hlokang tlhokomelo e eketsehileng ha lia tlaleheloa.

Fomu ea tokollo

Matlapa a koahetsoeng a 10 le 20 mg.
Ho matlapa a 7, 10 kapa a 14 ka lithunya tsa Al / PVC.
1, 2, 3, 4 lithutsoana ka lebokoseng la karete e nang le litaelo tsa tšebeliso.

Maemo a polokelo

Lenane la B. Sebakeng se omileng, se lefifi ka mocheso o ka tlase ho 25 ° C.
Qoba hole le bana.

Letsatsi la ho felloa ke nako

Lilemo tse 2 Se ke oa sebelisa kamora letsatsi la ho felloa ke nako le bontšitsoeng ka har'a sephutheloana.

Lipehelo tsa Khefu ea Litlama

Moetsi:
"M.J. Biopharm", India
113 Jolly moetsi oa Ntlo-II, Nariman Point, Mumbai 400021, India
Mohala: 91-22-202-0644 Fekse: 91-22-204-8030 / 31

Moemeli ho Rephabliki ea Russia
119334 Russia, Moscow, ul. Kosygina, 15 (GC Orlyonok), ofisi 830-832

E pakiloe:
Hloeking - Leksredstva OJSC
305022, Russia, Kursk, ul. 2 Aggregate, 1a / 18.
Mohala / Fekse: (07122) 6-14-65

Sebopeho, foromo ea tokollo

Ntho e sebetsang ea Liptonorm ke atorvastatin. E tlatselletsoa ka lintho tse thusang: calcium carbonate, cellulose, tsoekere ea lebese, hydroxypropyl cellulose, croscarmellose, magnesium stearate, titanium diode, polyethylene glycol.

Liptonorm ke letlapa le lesoeu le bosoeu le chitja. Ho na le liphapang tse peli tsa moriana o nang le dikahare tse sebetsang tsa 10 kapa 20 mg.

Ketso ea pharmacological

Atorvastatin ke inhibitor ea HMG-CoA inhibitor. Enzyme ena e hlokahala bakeng sa 'mele ho kopanya k'holeseterole. Molek'hule ea Liptonorm le eona e ka sebopeho sa eona. Lisele tsa sebete li e nka e le enzyme, e kenyeletsa karabelo ea ho etsoa ha k'holeseterole - ea emisa. Ntle le moo, thepa ea atorvastatin ha e tšoane le phallo ea HMG-CoA.

Boemo ba kholesterol boa theoha. Ho lefella khaello ea eona, 'mele o qala ho heletsa limolek'hule tse nang le LDL, e lebisang ho fokotseha ha khatello ea bona. Mohloli o eketsehileng oa k'holeseterole ke lisele tsa thipa. Ho tsamaisa sterol, lipoprotein tse "ntle" tse phahameng li hlokahala. Ka lebaka leo, palo ea bona ea eketseha.

Ho theoha ha k'holeseterole e felletseng, LDL, triglycerides e fokotsa tsoelo-pele ea atherosclerosis. Kaha lihlahisoa tse feteletseng tsa metabolism ea mafura li na le matla a ho bokella ka holim'a methapo ea mali. Ha tlhahiso e ba ea bohlokoa, e koahela karolo e fokolang ea leseli ka botlalo kapa ka botlalo. Atherosclerosis ea methapo ea pelo e lebisa ho otlang ha pelo, ho otloa ke boko, maoto le matsoho - ho thehoa ha liso tsa trophic, le necrosis ea maoto.

Ho sebetsa ha atorvastatin ho fokotsoa ho zero haeba motho a sa latele lijo tse reretsoeng ho theola cholesterol. Mmele ha o sebelise lisebelisoa tsa hae ho koahela bofokoli ba sterol, hobane bo tsoa lijong.

Maemo a kholesterol a qala ho tloaeleha ka mor'a libeke tse peli ho tloha ha a qala ho sebelisa lipilisi. Phello e phahameng e fihlella kamora libeke tse 4.

Atorvastatin metabolites e epolloa ka har'a bile, e hlahisoang ke sebete. Ha litho tsa 'mele li sa sebetse hantle, mokhoa ona o thatafala le ho feta. Ka hona, ka li-pathologies tsa sebete, moriana o laetsoe ka hloko.

Liptonorm: matšoao a ts'ebeliso

Ho latela litaelo tsa tšebeliso ea Liptonorm, lithethefatsi li fanoe e le tlatsetso ea kalafo ea ho ja bakeng sa:

• hypercholesterolemia ea mantlha,
• Hyperlipidemia
• heterozygous and homozygous Famer hypercholesterolemia e le tlatsetso ea kalafo ea ho ja,

Ts'ebeliso ea atorvastatin e thusa ho fokotsa kotsi ea ho otloa ke lefu la pelo ho bakuli ba nang le lefu la pelo. Ntle le moo, bakuli ba nkang Liptonorm hangata ha ba hloke ho thothomela, ho longoa, ho kena sepetlele ka mathata a pelo.

Mokhoa oa ts'ebeliso, litekanyetso

Pele a qala kalafo ka Liptonorm, hammoho le thupelong eohle, mokuli o lokela ho latela lijo.

Matlapa a nooa hang / ka letsatsi, ntle le ho bua ka lijo, empa ka nako e le 'ngoe. Tekanyo e khothalletsoang ea ho qala ke 10 mg. Ho feta moo, litekanyetso li khethoa ka bonngoe, ho nahanisisa ka liphetoho tsa cholesterol, LDL. Phetoho ea litekanyetso ha e fetisoe nako e le 'ngoe / libeke tse 4. Sekhahla se phahameng se lumelletsoeng ke 80 mg. Ka karabelo e fokolang ea 'mele ea ho nka atorvastatin, mokuli o fuoa statin e matla haholo kapa e tlatselletsoa ka lithethefatsi tse ling tse fokotsang k'holeseterole (li-sequence tsa bile acid, cholesterol inhibitors).

Ka ho hloleha ha sebete, ho khethoa ha Liptonorm ho lokela ho tsamaisana le ho lekola ts'ebetso ea 'mele. Haeba li feta ka mokhoa o tloaelehileng, sethethefatsi sea hlakoloa kapa ho beoa tekanyetso e fokotsitsoeng.

Contraindication, litla-morao

Liptonorm e kopantsoe le batho ba amehang ka atorvastatin, lactose, motsoako o mong le o mong oa lithethefatsi kapa analogue. Matlapa a pakiloe ka ho:

• mafu a sebete a hlobaetsang
• keketseho ea ALT, GGT, AST ka makhetlo a fetang a 3,
• tšoaetso e matla
• cirrhosis
• bana ba ka tlase ho lilemo tse 18.

Liptonorm ha e fuoe bo-'mè ba lebelletsoeng, basali ba anyesang. Haeba kemolo e rerile, moriana o emisoa bonyane khoeli pele ho letsatsi lena. Ka boimana bo sa reroang, o tlameha ho khaotsa ho sebelisa lithethefatsi, ebe o ea ngakeng hang-hang. O tla bua ka likotsi tse ka bang teng ho lesea, hape a fana ka litlhahiso mabapi le likhetho tse ka etsoang.

Boholo ba bakuli ba mamella lithethefatsi habonolo. Litla-morao, haeba li teng, li bonolo, lia nyamela kamora nako e khuts'oane. Empa mohlomong ketsahalo e sa lebelloang e matla.

Taeo ea Liptonorm e hlokomelisa ka litlamorao tse latelang:

• Ts'ebetso ea methapo: hangata ho hloka boroko, ho tsekela, ho opeloa ke hlooho, mala, ho otsela, ho hlobaela bosiu, amnesia, ho fokotseha / eketseha ha maikutlo, ho ruruha ha maikutlo, ho akheha maikutlong, ho hokahana ka sefahleho, ho holofala sefahlehong, ho se tsebe.
• Litho tsa kutlo: Ho bona habeli, ho lla litsebeng, mahlo a omileng, ho se utloe, glaucoma, ho khopamisa maikutlo.
• Ts'ebetso ea pelo: hangata - bohloko ba sefuba, ka seoelo migraine, palpitations, hypotension kapa khatello ea mali, arrhythmia, angina pectoris, phlebitis.
• Sistimi ea khahlapetso: khafetsa - bronchitis, rhinitis, ka seoelo - pneumonia, asthma ea bronchial, nosebleeds.
• Ts'oaetso ea ho ja: ho nyekeloa ke pelo, ho opeloa ke pelo, ho ruruha kapa lets'ollo, bohloko ba ka mpeng, khase, anorexia kapa takatso e eketsehang ea molomo, molomo o omileng, boroko, ho koenya maloetse, ho hlatsa, stomatitis, ho ruruha ha esophagus, leleme, gastroenteritis, hepatitis, hepatic colic, ulodenal ulcer , pancreatitis, jaundice, ho sitisoa ke matla a sebete, ho tsoa mali ho rectal, le marenene a tsoang mali.
• Sistimi ea musculoskeletal: khafetsa - ramatiki, hangata - mesifa ea leoto la maoto, bursitis, bohloko bo kopaneng, myositis, myopathy, myalgia, rhabdomyolysis, molumo oa mesifa.
• Sistimi ea lefu la genitourinary: khafetsa - tšoaetso ea lefutso, edema ea pheriferale, hangata - dysuria, ho ruruha ha menoana, mali a tsoang ka hara mpa, ho ruruha ha li-appendges tsa liteko, ho fokotse libido, ho hloka matla, ho holofala hoa mmele.
• Letlalo: alopecia, mofufutso o eketsehileng, eczema, dandruff, hemorrhage ea letheba.
• Litla-morao: Ho hlohlona, ​​ho ruruha, dermatitis, urticaria, hypersensitivity reaction, photosensitivity, anaphylaxis.
• Matšoao a laboratori: tsoekere e phahameng / e tlase, CPK e eketsehileng, phosphatase ea alkaline, ALT, AST, GGT, anemia, thrombocytopenia.
• Tse ling: ho nona ka boima ba 'mele, gynecomastia, ho mpefatsa le gout.

Hangata, batho ba tsubang, matahoa, bakuli ba nang le lefu la tsoekere, ho se lekane ha qoqotho, mafu a sebete, hypotension ba na le litlamorao.

Emisa Liptonorm, hape le ngaka ea hau haeba:

• bohloko bo boholo ba 'mele bo sa hlalosoeng kapa bofokoli,
• mocheso o eketseha
• cramps.

Tšebelisano

Lithethefatsi li ka arabela ka litlhare tse latelang:

• li-antacid (omeprazole, almagel),
• digoxin
• erythromycin ,cacithromycin,
• proteinase inhibitors
• lithibela-pelehi tse ling tsa molomo
• fibrate
• warfarin
• itraconazole, ketoconazole.

Setlhare sena ha se rekisoe ke lik'hemisi tsa limela Russia. O felletse setifikeiti sa ho ingolisa. Theko ea Liptonorm ka nako ea ho nyamela ha thekiso e ne e le li-ruble tse 284 ka sephutheloana sa 10 mg, li-ruble tse 459 ka 20 mg.

Ho haella ha litlhare tsa meriana tsa Liptonorm ha se bothata. Ho na le lipapiso tse ngata tsa lithethefatsi ka ntho e le 'ngoe e sebetsang. O ka botsa litlhare:

• Atoris
• Anvistat
• Atomax
• Ator
• Tulip
• Atorvastitin-OBL,
• Atorvastatin-Teva,
• Atorvastatin MS,
• Atorvastatin Avexima,
• Atorvox
• Vazator
• Lipoford
• Liprimar
• Novostat,
• Torvas
• Torvalip
• Torvacard
• Torvazin.

Ntle le lithethefatsi tse kaholimo, o ka nka li-analog tsa Liptonorm ka mochini oa ts'ebetso:

• simvastatin - li-ruble tse 144- 346.,
• lovastatin - li-ruble tse 233-475.,
• rosuvastatin - 324-913 rub.,
• fluvastatin - 2100-3221 rub.

Li-statin tsohle li na le ts'ebetso e ts'oanang ea ts'ebetso, empa e 'ngoe le e' ngoe ea tsona e na le likarolo tsa ts'ebeliso. Ka hona, kamehla buisana le ngaka ea hau pele u fetola lithethefatsi.

Lintho tse hlophisitsoeng ke bangoli ba projeke
ho latela leano la ho hlophisa sa sebaka seo.

Sokolla foromo le sebopeho

Liptonorm e fumaneha ka mokhoa oa matlapa: a koahetsoeng ka khetla e tšoeu, pota, biconvex, nakong ea khefu - e tšoeu kapa e batla e le tšoeu (li-pcs tse 14.).

Ntho e sebetsang ea lithethefatsi ke atorvastatin (ka sebopeho sa letsoai la calcium). Letlapeng le le leng le na le 10 mg kapa 20 mg.

Baeti: crosscarmelose, hydroxypropyl cellulose, magnesium stearate, pakeng tsa 80, lactose, hydroxypropyl methyl cellulose, cellcose ea microcrystalline, titanium dioxide, calcium carbonate, polyethylene glycol.

Foromo le sebopeho sa litekanyetso

Sesebelisoa se ka sehloohong sa Liptonorm ke Atorvastatin calcium trihydrate ka mokhoa oa letsoai la calcium. Har'a likarolo tsa eona tse thusang li kenyeletsa:

• calcium carbonate
• Lilemo tse 80,
• MCC
• lisebelisoa tse eketsang lijo E463 le E572,
• sodium hammart
• lactose
• metsi a hloekisitsoeng.

Liptonorm e hlahisoa ka sebopeho sa letlapa. Matlapa a koahetsoeng a 10 mg kapa 20 mg a fumaneha ka bongata ba 7, 10, 14, 20, 28 kapa 30 likhomphutha.

Matšoao a ho sebelisoa

Setlhare se laeloa ho eketsa cholesterol. Ketso ea eona e etselitsoe ho thibela litaba tsa lipid maling. Liptonorm e lokela ho sebelisoa tekong e boletsoeng ke ngaka.

Liptonorm ea lithethefatsi e na le ts'ebetso e mengata. Setlhare se na le lipid-lowing le anti-atherosranceotic effect. Kameho e fokotsang lipid ea lithethefatsi Liptonorm ke hore ntho e sebetsang e kenya letsoho ho sitiseng k'holeseterole le ho tlosa metsoako ea LDL plasma ea mali.

Matla a anti-atherosulinotic a thehiloe molemong oa hore lithethefatsi li khona ho hatella kholo ea lisele methapong ea mali le ho theola litaba tsa likarolo tsa lipid tsa mali. Ka lebaka la ts'ebetso e pharaletseng ea ts'ebetso, moriana o lokela ho fuoa mafu a latelang:

• tloaelo ea liphatsa tsa lefutso
• dyslipidemia,
• hetero - kapa sebopeho sa homozygous sa mofuta oa hypercholesterolemia ea lelapa.

Liptonorm ha ea lokela ho ferekanngoa le lithethefatsi bakeng sa ho fokotsa boima ba 'mele. Ntle le hore ena ea morao-rao ke tlatsetso ea lijo, e rekisoa feela ka li-capsules.

Litlamorao

Haeba mokuli a hlokomoloha litlolo ka boomo kapa a fetisa tekanyetso e behiloeng ea matlapa, a ka ameha kotsing ea litlamorao. Ho se lumellane le melao ea phekolo e ka baka ho hloleha Litsamaiso le litho tse latelang:

1. CNS Lintho tse ka sehloohong tse bontšang ho se sebetse hantle ha tsamaiso ea methapo ea kutlo ke ho tsekela le ho sitisa boroko. Maemong a ikhethileng, bakuli ba ba le matšoao a kang bosiu bo bobe, asthenia, ataxia, paresis le hyperesthesia, e lebisang ho tepelletseng maikutlong nako e telele.
2. Litho tsa kutlo. Matšoao a tlolo ea ts'ebetso ea bona a nkuoa e le hemorrhage ka leiong la mahlo, khaello ea mongobo oa conjunctival, ho hloka maikutlo leha e le afe ha ho ja, tahlehelo ea bokhoni ba ho bona monko.
3. Sistimi ea lefutso. Ts'oaetso ea urological le ea botšehali, mathata a ho ntša metsi, nts'etsopele ea ho hloleha ho hlaphoheloa ke methapo nakong ea kalafo, ho fokotseha hoa litšitiso tse atileng haholo nakong ea kalafo le Liptonorm.
4. Sistimi ea limpho. Tlhahlobo ea kalafo ea bongaka e ka baka kholo ea mafu a mali - lymphadenopathy, anemia kapa thrombocytopenia.
5. Phekolo ea lijo. Ho se lumellane le melao ea litekanyetso tsa matlapa ho latela litaelo ho lebisa ho nts'etsopele ea mafu a methapo ea ka mpeng le sebete, tse bonahatsoang ke ho thunya, ho ruruha, ho hlatsa, le moea o matla oa hepatic, esita le hepatitis.
6. Tsamaiso ea pelo. Bakuli ba ka ba le khatello e phahameng ea mali, angina pectoris, khatello ea sefubeng.
7. Sistimi e tsitsitseng. Litla-morao tse ka bang tsa dermatological kapa allergic li kenyelletsa rashes, ho hlohlona, ​​seborrhea, eczema, ka seoelo urticaria kapa anaphylactic.

Litaelo tsa ho sebelisoa

Liptonorm ke moemeli oa sehlopha sa lithethefatsi tse sebelisoang kalafo ea maemo a feteletseng a lipid. Atorvastatin - karolo ea mantlha e sebetsang, e na le phello e matla ea ho fokotsa lipid, ke hore, e thusa ho fokotsa litaba tsa lipid maling. Likahare tsa eona maling li nyoloha kamora hora e le 'ngoe ka mor'a kopo. Hoseng, palo ena e phahame ka 30% ho feta mantsiboea.

Liphetho tsa ts'ebeliso ea li-statins li bonoa kamora matsatsi a 14. Phello e phahameng e fihlella feela kamora khoeli ea ts'ebeliso.

Ho nwa moriana ona ha ho a itshetleha ka ho ja lijo tse ngata mmeleng. Boemo feela bo kenyang katleho ea ts'ebeliso ea lithethefatsi ke ho kenella ha matlapa a letsatsi le letsatsi ka nako e le 'ngoe. Mokuli ha aa lokela ho feta se tloaelehileng - 10 mg ka letsatsi. Ho eketsa tekanyetso ea letsatsi le letsatsi ho ka baka kotsi e kholo ho bophelo bo botle le ho baka maemo a sa rateheng.

Pele ba qala kalafo, lingaka li lokela ho lekola ho sebetsa ha sebete. Litsebi li khothaletsa tlhokomeliso le ho etela ngaka khafetsa ho lekola ts'ebetso ea sebete bakeng sa likhoeli tsa 3 kamora ho qala kalafo. Phetoho ea tekanyetso e ka etsoa libeke tse 'maloa kamora ho qala kalafo, empa eseng hangata ho feta nako e le' ngoe ka khoeli. Nakong ea kamohelo ea hae, lingaka li lokela ho ba le likhoeli tse ling le tse ling tse 6. laola liphetoho lipakeng tsa enzyme.

Ho latela maemo a ts'ebeliso, matlapa a tlameha ho bolokoa sebakeng se pholileng. Matshwao a amohelehang a mocheso kamoreng ena + degrees 25.

Sebelisa nakong ea bokhachane

Sesebelisoa se sebetsang sa lithethefatsi ha sea lumelloa ho bakuli nakong ea kemolo le nakong ea lebese (kanyeso) ka lebaka la litlamorao tse mpe tse ka bang teng 'meleng oa lesea le sa tsoa hlaha. Haeba mokuli a rera ho ima, ho molemo ho mo tlohela ka likhoeli tse 'maloa. Basali nakong ea kalafo le Liptonorm ha baa lokela ho hlokomoloha bokhachane.

Liphapang tse ling li kenyelletsa bongoaneng le bohlankana. Tlhahisoleseling mabapi le kalafo ea bana ba nang le moriana ho fihlela joale ha e fumanehe.

Theko ea lithethefatsi

Theko ea lithethefatsi Liptonorm e khethoa ke litekanyetso tse 'maloa - palo ea mabokose a sephutheloaneng, litekanyetso, jj. Ka karolelano, matlapa a 10 mg a ka rekoa k'hemisteng bakeng sa li-ruble tse 200-250. Litsenyehelo tsa pakete ea 28 likhomphutha. 20 mg e ngoe le e ngoe ke li-ruble tse 400-500.

Naheng ea Ukraine, theko ea lithethefatsi ka tekanyetso ea 20 mg ke 250-400 UAH.

Analogs Liptonorm

Leha taba ea hore Liptonorm ke sethethefatsi se sebetsang hantle, ha e ea lokela bakuli bohle. Hypersensitivity ho karolo e le 'ngoe ea lithethefatsi mme e fetisoa ke mabaka a mabeli a mantlha a ho e khutlisa ka analogue e theko e tlaase.

Meriana e latelang ke e 'ngoe ea lipapatso tsa Liptonorm:

Tlhahlobo

Tlhahlobo ea ts'ebeliso ea eona e bonts'a hore lingaka hangata li fa mokuli lithethefatsi ntle le litlhaloso tse qaqileng mabapi le likarolo tsa ts'ebetso ea eona le litlamorao tse ka bang teng.

Tamara, Moscow: “Matsatsing a pele kamora ho sebelisa lipilisi, ke ile ka qala ho ba le mahlaba ka mpeng, ka honotha ka mpeng, mme matsatsi a 'maloa hamorao - ho nyekeloa le pelo le ho hlatsa. Ha ke a ka ka kopanya lipontšo tsena le ho nka Liptonorm. Kaha esale ke tšoenngoa ke mathata a ho kula ka mpeng ho tloha bongoaneng ka phetoho e nyane haholo lijong tsa ka, ke ile ka fetohela ho ngaka ea mafu a gastroenterologist. Ka thuso ea ngaka, ke hlokometse se bakileng pherekano ka mpeng, empa ke ntse ke tsotella potso. Ke hobane'ng ha setsebi sa ka sa phepo se sa ntlhokomeliso ka litlamorao?

Ekaterina, Novosibirsk: "Boima ba ka bo boholo bo bile le nna ho tloha lilemong tsa ka tsa bocha, empa ke ha ke le lilemo li 30 feela ke ileng ka etsa qeto ea ho itlhokomela le ho fumana sesosa sa bothata ba ka. Boithuto ba laboratori bo bontšitse hore sesosa ke cholesterol e phahameng mme setsebi sa phepo se mpehetse Liptonorm.Ka letsatsi la pele, khatello ea ka ea mali e ile ea nyolohela ho tse 150. Letsatsing le hlahlamang hoseng khatello e ne e tloaelehile, empa kamora lijo tsa mots'eare e ile ea boela ea fihla ho 160. Kamora moo ke nkile qeto ea ho bala litaelo hape qetellong ke utloisise se etsahalang. Khatello ea mali e phahameng ke litla-morao tsa meriana. Khatello e ile ea emisa matsatsi a 5 feela ka mor'a ho qala kalafo. ”

Ha re akaretsa lintlha tsohle tse boletsoeng kaholimo mabapi le tšebeliso ea matlapa a Liptonorm, ho lokela ho fihlela qeto ea hore hoa hlokahala ho buisana le ngaka pele u e sebelisa. Pele, sena se bakoa ke taba ea hore lithethefatsi ke tsa sehlopha sa li-statins tse ka loantšang keketseho ea cholesterol. Joalokaha u tseba, ho khethoa kapa ho hlakoloa ha moemeli leha e le ofe oa lihormone ho ka etsoa feela ke setsebi.

Taba ea bobeli, moriana o na le li-contraindication le litla-morao tse ngata tse tsoang mpeng ea mokokotlo, tsamaiso ea methapo ea methapo, methapo ea pelo le lits'ebetso tse ling tsa bohlokoa. Setsebi se lokela ho beha tekanyetso, se hlalose likarolo tsohle tsa kopo, hape le ho tsebisa mokuli ka mathata a ka bang teng.

Tekanyetso le tsamaiso

Pele a fana ka Liptonorm le nako eohle ea tšebeliso ea eona, mokuli o lokela ho latela lijo tse fanang ka phallo ea lipids tsa mali.

Moriana o nooa ka molomo nako e le 'ngoe ka letsatsi, ho sa natsoe lijo, ka nako e le' ngoe.

Tekanyetso ea pele ea letsatsi le letsatsi hangata ke 10 mg. Ka mor'a moo, litekanyetso li fetoloa ka bonngoe, ho latela se ngotsoeng k'holeseterole ea lipoprotein tse tlaase. Nako le nako lipakeng tsa liphetoho tsa tekanyetso ha ea lokela ho ba ka tlase ho libeke tse 'ne. Sekhahla se phahameng se lumelletsoeng letsatsi ka leng ke 80 mg.

Litlamorao

Litlamorao tse ka bakoang ke lithethefatsi (hangata - ho feta 2%, ka seoelo - ka tlase ho 2%):

• Ts'ebetso ea methapo e bohareng: khafetsa - ho tsekela, ho hloka boroko, ka seoelo - malaise, asthenic syndrome, ho otsela, hlooho e bohloko, ho lora bosiu, ho imeloa kelellong, ho ruruha ha pelo, ho ferekana kelellong, khatello ea maikutlo, ho ferekana kelellong, khatello ea maikutlo, ho lahleheloa ke kelello
• Ts'ebetso ea pelo: hangata ho opeloa ke sefuba, ho se sebetsane ka morao ho pelo, arrhythmia, vasodilation, ho eketseha ha pelo, angina pectoris, khatello ea mali e eketsehileng, phlebitis,
• Litho tsa kutlo: ho nyekeloa ke pelo, glaucoma, hemorrhage ea mahlo, amblyopia, tšitiso ea sebaka sa bolulo, parosmia, lla litsebeng, ho se utloe litsebeng, ho kheloha ha tatso, ho lahleheloa ke tatso,
• Sistimi ea khalemelo: khafetsa - Rhinitis, bronchitis, ka seoelo - nosebleeds, pneumonia, asthma ea bronchial, dyspnea,
• Sistimi ea tšilo ea lijo: khafetsa - cheilitis, marenene a tsoang mali, ho ruruha le maqeba a ho ruruha ha molomo, molomo, ho omella, ho nyekeloa, lets'ollo, ho nyekeloa ke pelo, ho nyekelwa ke pelo, gastralgia, belching, bohloko ba ka mpeng, ho hlatsa, dysphagia , esophagitis, anorexia kapa takatso e eketsehileng ea lijo, seso sa duodenal, hepatic colic, gastroenteritis, hepatitis, lefu le sa sebetseng hantle la sebete, cholendatic jaundice, pancreatitis, melena, ho tsoa mali hape,
• Sistimi ea genitourinary: hangata - - edema ea pheriferale, ts'oaetso ea urogenital, ka seoelo - hematuria, nephritis, nephrourolithiasis, dysuria (ho kenyelletsa ho imoloha ha methapo kapa ho e boloka ka urine, nocturia, polakiuria, ho ntša mokokotlo), metrorrhagia, ho tsoa mali ke mosali, lefutso. ejaculation, fokotsehile libido, ho hloka matla,
• Sistimi ea musculoskeletal: khafetsa - ramatiki, hangata - tendosynovitis, bursitis, myositis, myalgia, arthralgia, torticollis, leqeba la leoto, contracture e kopaneng ea, mesifa hypertonicity, myopathy, rhabdomyolysis,
• Sistimi ea Hematopoietic: lymphadenopathy, anemia, thrombocytopenia,
• Liphetoho tsa letlalo le mathata: hangata ha - ho fufuleloa ho eketsehileng, seborrhea, xeroderma, eczema, petechiae, ecchymosis, alopecia, ho hlohlona, ​​letlalo, lekhopho, ho kopana le dermatitis, ka seoelo - sefahleho edema, angioedema, urticaria, photosensitivity, erythema erythema. Stevens-Johnson syndrome, anaphylaxis,
• Matšoao a laboratori: ka seoelo - albinuria, hypoglycemia, hyperglycemia, ts'ebetso e eketsehileng ea alphaline phosphatase, serum creatinine phosphokinase le transpase tsa hepatic,
• Tse ling: ka seoelo - mastodynia, gynecomastia, phaello ea boima ba mmele, ho mpefala ha leqeba.

Litaelo tse khethehileng

Ho pholletsa le nako eohle ea kalafo, ho hlokahala hore ho hlahlojoe ka hloko matšoao a kliniki le a laboratori ea lits'ebetso tsa 'mele. Haeba liphetoho tse kholo tsa pathological li fumanoa, tekanyo ea Liptonorm e lokela ho fokotsoa kapa tšebeliso ea eona e emisoe ka botlalo.

Pele o fana ka moriana, ka mor'a libeke tse 6 le tse 12 kamora ho qala kalafo, kamora ho eketseha ha tekanyetso ka ngoe, hammoho le nako le nako nakong ea kalafo (mohlala, likhoeli tse ling le tse ling tse 6), ts'ebetso ea sebete e lokela ho beoa leihlo. Phetoho ea ts'ebetso ea enzyme hangata e bonoa likhoeling tse 3 tse qalang tsa ho nka Liptonorm. Tabeng ea ts'ebetso e eketsehileng ea transpase ea hepatic, bakuli ba lokela ho ba le tlhokomelo e haufi ea bongaka ho fihlela matšoao a khutlisoa. Haeba boleng ba alanine aminotransferase (ALT) kapa aspartate aminotransferase (AST) bo phahame ho feta makhetlo a 3 ho feta theko e ts'oanang ea congenital adrenal hyperplasia, ho kgothaletswa ho fokotsa tekanyetso kapa ho emisa moriana.

Hoa hlokahala ho bapisa molemo o lebelletsoeng le tekanyo ea kotsi haeba ho hlokahala ho fana ka Liptonorm ho mokuli ea fumanang cyclosporine, erythromycin ,cacithromycin, immunosuppressants, fibroic acidiv derivatives, nicotinic acid (litekong tse nang le lipid-lowing effect), li-antifungal agents tse hlahisoang ke azole. Haeba matšoao a bohloko ba mesifa, bofokoli kapa mokhathala o hlaha, haholo likhoeling tsa pele tsa kalafo kapa ka keketseho ea tekanyetso ea lithethefatsi life, boemo ba mokuli bo lokela ho beoa leihlo ka hloko.

Haeba ho na le mabaka a kotsi bakeng sa nts'etsopele ea ho hloleha ha rerese ka mpeng ka lebaka la rhabdomyolysis (mohlala, ho fokola ha methapo ea kutlo, ho ruruha ho matla ha metabolic le endocrine, ts'oaetso e matla, ho tepella maikutlo, ts'ebetso e kholo ea ts'ebetso, ho se leka-lekane ha electrolyte), hammoho le maemong a tebileng a ka bonts'ang. nts'etsopele ea myopathy, Liptonorm e tlameha ho felisoa ka nakoana kapa ka botlalo.

Mokuli o lokela ho hlokomelisoa ka tlhokahalo ea ho ea ngakeng hang-hang haeba u e-na le bothata ba mesifa kapa mesifa e sa hlaloseheng, haholoholo haeba ba tsamaisana le malaise le / kapa feberu.

Ho ne ho se na litlaleho tsa tšusumetso e mpe ea Liptonorm mabapi le bokhoni ba ho khanna makoloi le ho etsa mosebetsi o hlokang tlhokomelo.

Ho sebelisana le lithethefatsi

Li-Immunosuppressants, li-antifungal agents tse tsoang ho azole, fibrate, cyclosporine, erythromycin ,cacithromycin, nicotinamide e eketsa khatello ea mali ea atorvastatin ka plasma ea mali le kotsi ea ho ba le myopathy.

Karolo ea ntho e sebetsang ea Liptonorm e boetse e eketsoa ke li-inhibitors tsa CYP3A4.

Li-antacids li fokotsa bongata ba atorvastatin ka 35%, empa li se ame se kahare ho cholesterol ea lipoprotein tse tlase.

Ha u nka Liptonorm ka tekanyetso ea letsatsi le letsatsi ea 80 mg ka nako e le 'ngoe le digoxin, khatello ea mali le eona e eketseha ka 20%.

Liptonorm, e nooang ka tekanyetso ea letsatsi le letsatsi ea 80 mg, e eketsa bongata ba lithibela-pelehi tsa molomo tse nang le ethinyl estradiol kapa norethidrone ka 20%.

Phello ea hypolipidemic ea ho kopana ha atorvastatin le colestipol e phahame ho feta litlamorao tse fumanehang ho lithethefatsi ka bomong.

Tabeng ea tšebeliso e tšoanang ea warfarin matsatsing a pele a kalafo, nako ea prothrombin ea fokotseha, empa kamora matsatsi a 15 letšoao lena, e le molao, le tloaela. Ka lebaka lena, bakuli ba fumanang motsoako o tšoanang ba lokela ho laola nako ea prothrombin hangata ho feta kamoo ho tloaelehileng.

Nakong ea kalafo, ha e khothalletsoe ho sebelisa lero la morara, hobane e ka thusa ho eketsa bongata ba atorvastatin ka plasma ea mali.