Pentilin ea lithethefatsi: litaelo tsa tšebeliso

Kahare, nakong ea lijo kapa ka mor'a lijo, o kometse ka hohle, 400 mg makhetlo a 2-3 ka letsatsi, nete joalo, bonyane libeke tse 8.

Ho / kapa / ho / ente: 50-100 mg / letsatsi (ka saline) bakeng sa metsotso e 5. Ho / ho kapa ho / infusion: 100-400 mg / ka letsatsi (ka saline ea mmele), nako ea infravenousous - metsotso e 90-180, ka / metsotso e 10-30, lethal dose e kholo ea letsatsi le letsatsi ea 800 le 1200 mg, ka ho latellana. Ho kenella ka nako e telele - 0,6 mg / kg / h bakeng sa lihora tse 24, lethal dose le phahameng la letsatsi le letsatsi la 1200 mg.

Ha Cl creatinine e le ka tlase ho 10 ml / min, lethal dose le fokotsoa ke 50-70%. Bakeng sa bakuli ba hemodialysis, kalafo e qala ka tekanyetso ea 400 mg / ka letsatsi, e eketsoang ka mokhoa o tloaelehileng ka nako ea bonyane matsatsi a 4.

Sokolla foromo le sebopeho

  • Tharollo bakeng sa taolo e kenang le e kenang ka hare: e pepeneng, e se nang 'mala kapa e sootho hanyane ka' mala (5 ml ho ampoules, ampoules tse 5 ka moqomong kapa pampiring ea polasetiki, blister kapa tray e ngata ka lebokoseng la karete.
  • matlapa a ts'ebetso ea nako e telele, a koahetsoeng ka filimi: oval, biconvex, e tšoeu (li-pcs tse 10 ka blister, ka lebokoseng la karete e 2 ea lithupa).

Karolo e le 'ngoe ea tharollo ea Pentilin (5 ml):

  • ntho e sebetsang: pentoxifylline - 100 mg,
  • dikarolo tse eketsehileng: sodium hydrogen phosphate dihydrate, sodium dihydrogen phosphate dihydrate, sodium chloride, disodium edetate, metsi a ente.

Karolo e le 'ngoe ea "tablet" Pentilin:

  • ntho e sebetsang: pentoxifylline - 400 mg,
  • likarolo tse ling: magnesium stearate, hypromellose, macrogol 6000, silicon dioxide anhydrous colloidal,
  • khetla: hypromellose, macrogol 6000, talc, titanium dioxide E171.

Mofumahali

Pentoxifylline - ntho e sebetsang ea Pentilin - antispasmodic e tsoang sehlopheng sa purine e ntlafatsang thepa ea rheological (fluidity) le microcirculation ea mali. Mochine oa ts'ebetso ea lithethefatsi o bakoa ke bokhoni ba oona ba ho thibela phosphodiesterase le ho eketsa phallo ea li-cyclic AMP ka liplateleteng le ATP liseleng tse khubelu tsa mali, ha a ntse a khotsofatsa matla a teng, ka lebaka la hore vasodilation e qala, khatello ea methapo ea methapo ea mali e fokotseha, sekhahla le bophahamo ba motsotso oa mali bo ntse bo eketseha, ha sekhahla sa pelo se sa eketsehe haholo. ea fetoha.

Pentoxifylline e hlapolla methapo ea methapo ea kutlo, e eketsang phepelo ea oksijene ho myocardium (antianginal athari), le methapo ea mali ea matšoafong, e ntlafatsang oxygenation ea mali.

Lithethefatsi li eketsa molumo oa mesifa ea ho hema, haholo-holo mokokotlo le mesifa ea kahare.

E ntlafatsa methapo ea mali libakeng tse pharalletseng ho potoloha ha mali, e eketsa leselamo la membrane ea erythrocyte, e fokotsa phallo ea mali.

Ka lesapo le nang le matla la methapo ea methapo ea kutlo (Pentiment claudication), Pentilin e lelefatsa sebaka sa ho tsamaea, e tlosa mesifa ea bosiu ea mesifa ea namane le bohloko ba ho phomola.

Mofumahali

Pentoxifylline e na le metabolism e ngata liseleng tse khubelu tsa mali le sebete. Kamora ho tsamaisoa ka molomo, e kanna ea amoheloa ka botlalo ho tsoa mokhoeng oa ka mpeng. Foromo ea nako e telele ea matlapa e fana ka tokollo e tsoelang pele ea karolo e sebetsang ea sethethefatsi le ho ts'oaroa ha eona e ts'oanang.

Pentoxifylline e feta karolong ea mantlha e kenang ka har'a sebete, e hlahisang metabolite e 'meli e ka sehloohong ea meriana: 1-3-carboxypropyl-3,7-dimethylxanthine (metabolite V) le 1-5-hydroxyhexyl-3,7-dimethylxanthine (metabolite I), plasma mahlaseli a eona a phahametseng makhetlo a 8 le a 5 ho feta pentoxifylline, ka ho latellana.

Pentoxifylline le metabolites ea eona ha li tlamele liprotheine tsa plasma.

Ea lithethefatsi ea nako e telele e fihla eona boholo ba mahloriso ka hare ho lihora tse 2-5. E ajoa ka ho lekana. Ho felisoa ha halofo ea bophelo ke lihora tse 0.5-1,5.

Bophelo ba halofo ea pentoxifylline kamora lethal entravenous ea 100 mg ke hoo e ka bang lihora tse 1,1. E na le palo e kholo ea phepelo (kamora ho kenngoa ha metsotso e 30 ea 200 mg - 168 L), hammoho le tumello e phahameng (4500-5100 ml / min).

94% ea lethal dose le amoheloang e hlahisoa ke liphio ka mokhoa oa metabolites (haholo metabolite V), e ka bang 4% - ke mala. Maemong ana, ho fihla ho 90% ea lethal dose e pepuoa nakong ea lihora tse 4 tsa pele. Excretion ea metabolites e fokotsa butle ho bakuli ba nang le ts'oaetso e matla ea renal. Ha ts'ebetso ea ho se sebetse hantle ha sebete, nako ea bophelo ea pentoxifylline e ea lelefatsoa 'me bioavailability ea eona ea eketseha.

Pentoxifylline e epuoa ka lebese la matsoele.

Matšoao a ho sebelisoa

  • ho sitoa ho utloa hantle ha masapo,
  • e sa feleng, ea subacute le e hlobaetsang ho potoloha ha mali ka mokokotlong le mokokotlong,
  • kotsi e sa foleng ea methapo ea pelo e qalehileng ka tšimoloho ea tlhaho,
  • endlitterate endarteritis,
  • mathata a potoloha a potoloha ka lebaka la atherosclerosis, lefu la tsoekere mellitus (lefu la tsoekere),
  • angiopathy (paresthesia, lefu la Raynaud),
  • lesapo la mokokotlo la trophic ka lebaka la ho senyeha ha venous kapa arterial microcirculation (serame, lefu la post-thrombophlebitis, trophic ulcers, gangrene),
  • discirculatory le atherosselotic encephalopathies.

Contraindication

  • hemorrhages
  • hemorrhages
  • ho tsoa mali haholo
  • hemorrhagic stroke,
  • thata arrhythmias,
  • Hypotension
  • infarction ea bohlokoahali
  • leqeba le matla la methapo ea methapo ea kutlo kapa lisele tsa mokokotlo,
  • porphyria
  • moimana, ho nyeka,
  • lilemo tse 18
  • hypersensitivity ho likarolo tsa Pentilin kapa methylxanthine e ngoe.

  • hypotension
  • pelo e sa foleng
  • mosebetsi o sa sebetseng oa renal (tumello ea creatinine ka tlase ho 30 ml / min),
  • ho hloka matla ha sebete,
  • tloaelo e eketsehileng ea ho tsoa mali, ho kenyeletsoa ha ho sebelisoa li-anticoagulants, mathata a tsamaiso ea mali ea mali, kamora ho kenella lits'ebetsong tsa ho buoa.
  • peptic ulcer ea mala le duodenum ea matlapa.

Tharollo ea entetso

Ka mokhoa oa tharollo, Pentilin e tsamaisoa kahare kapa ka likhoka.

Ngaka e beha qeto ea tsela ea tsamaiso le tekanyo e nepahetseng ea moriana o mong le o mong, ho latela boholo ba mathata a potoloha le ho mamella pentoxifylline ka kotloloho. Ho kenella ka hare ho mpa ho etsoa maemong a phahameng.

Ka molao, ho bakuli ba baholo, moriana o fanoa ka makhetlo a mabeli ka letsatsi (hoseng le thapama), 200 mg (2 ampoules ea 5 ml ka ngoe) kapa 300 mg (3 ampoules ea 5 ml ka ngoe) ka 250 kapa 500 ml ea sodium chloride solution. kapa tharollo ea ringer. Ho lumellana le tharollo e meng ea infusion ho lokela ho hlahlojoa ka thoko, empa ho lokela ho sebelisoa litharollo tse hlakileng feela.

Nako ea infusion ke bonyane metsotso e 60 bakeng sa lethal dose la pentoxifylline 100 mg. Maqhubu a kenyellelitsoeng a ka fokotseha boteng ba mafu a kopaneng, mohlala, ho nyekeloa ke pelo. Maemong a joalo, ho molemo ho sebelisa infuser e ikhethang ho laola infusion.

Kamora ho kenngoa ha letsatsi, haeba ho hlokahala, matlapa a Pentilin 400 mg a kenyelletsoa - 2 likhomphutha. Haeba infusions tse peli li etsoa nako le nako, tafoleng e le 'ngoe e ka nkuoa pele (ka hora ea 12 thapama).

Maemong ao ho kenella ka mokhoa o kenang ka lebaka la maemo a bongaka ho ka etsoang hang feela ka letsatsi, tsamaiso e eketsehileng ea Pentilin matlapeng a palo ea li-pcs tse 3 li ka khonahala. (Matlapa a mabeli mots'eare, 1 mantsiboea).

Maemong a tebileng, ho etsa mohlala, ka lefu la gangren, ulcers ea trophic ea sethala sa IV - IV ho latela sehlopha sa Fontaine - Lerish - Pokrovsky, bohloko bo boholo ba phomolo, taolo e telele ea methapo ea meriana e bontšitsoe - lihora tse 24.

Litlhahiso tse khothalelitsoeng tsa tsamaiso ea methapo ea methapo: qalong ea kalafo - 100 mg ea pentoxifylline ka 50-100 ml ea tharollo ea chloride ea 0,9%, ka matsatsi a latelang - 100-400 mg ka 50-100 ml ea 0,9% sodium chloride solution. Sekhahla sa tsamaiso ke 10 mg / motsotso, nako ea tsamaiso ke metsotso e 10-30.

Motšehare, o ka kenya sethethefatsi ka tekanyetso ea ho fihlela ho 1200 mg. Maemong ana, tekanyetso ea motho ka mong e ka baloa ho latela foromo e latelang: 0,6 mg ea pentoxifylline ka kilo ea boima ba 'mele ka hora. Ka hona, tekanyetso ea letsatsi le letsatsi e tla ba 1000 mg bakeng sa mokuli ea nang le boima ba 'mele ba 70 kg, 1150 mg bakeng sa mokuli ea nang le boima ba' mele ba 80 kg.

Bakuli ba nang le bothata ba ho phekoloa ka methapo, ho latela litheko tsa motho ka mong, ba fokotsa lethal dose ka 30-50%.

Phokotso ea litheko le eona e hlokahala ho bakuli ba nang le ts'ebetso ea sebete e matla haholo, ha mamello ea Pentilin ka bonngoe e lokela ho nkuoa.

Ho khothalletsoa ho qala kalafo ka litekanyetso tse tlase ka keketseho ea butle butle ea bakuli ba nang le khatello e tlase ea mali, hammoho le ho bakuli ba tloaetseng ho theola khatello ea mali (mohlala, ka lefu le matla la pelo, hemodynamically stenosis ea methapo ea methapo).

Matlapa a Pentilin 400 mg a lokela ho nooa ka molomo, ka mor'a ho ja: metsa ka botlalo mme o noe metsi a mangata.

Motsoako o khothalelitsoeng ke Letlapa le le leng la 2 kapa makhetlo a 3 ka letsatsi. Se ke oa feta tekanyetso ea letsatsi le letsatsi ea 1200 mg.

Bakuli ba nang le bothata ba ho phekola ba masapo bo sa feleng (tumello ea creatinine

Foromo ea litekanyetso

Matlapa a koahetsoeng ka filimi ea 400 mg

Letlapa le leng le na le

ntho e sebetsang - pentoxifylline 400 mg,

Baeti: hypromellose, macrogol 6000, "magnesium stearate" silicon dioxide e tsoang ho colloidal anhydrous,

Ho hlophisoa ha khetla: hypromellose, macrogol 6000, titanium dioxide (E 171), talc.

Matlapa a nang le sebopeho sa oval a nang le biconvex holim 'a ntho e koahetsoeng ka koae e tšoeu ea filimi

Melemo ea pharmacological

Mofumahali

Kamora ho tsamaisoa ka molomo, pentoxifylline e potlakile ebile e kenella ka botlalo. Bolooa ba bioavailability ba litheolelo tsa nako e telele tsa pentoxifylline ke 20%. Ho ja hoa fokotseha, empa ha ho fokotse botlalo ba litlhare.

Khanyetso e kholo ea plasma e etsahala nakong ea lihora tse peli ho isa ho tse nne. Pentoxifylline e pepesitsoe lebeseng la matsoele, e fumanoe kamora lihora tse peli kamora ts'ebetso, ka bobeli - e sa fetoheng le ka mokhoa oa metabolites.

Pentoxifylline e tšelisoa haholo-holo ka har'a sebete le hanyane hanyane liseleng tse khubelu tsa mali. E feta metabolism ea bohlokoa le e hlakileng phetong ea pele. Metsoako ea plasma ea metabolites e sebetsang e phahame makhetlo a 5 le a 8 ho feta khatello ea pentoxifylline. E tšelisoa ke contraction (ka α-keto reductase) le oxidation.

Metabolites e hloekisoa haholo ka har'a moroto (hoo e ka bang 95%). Hoo e ka bang 4% ea tekanyetso e nkuoeng e tšolloa ka mantle. Ka ho se sebetse hantle haholo ha renal, ho pepeseha hoa metabolites ho fokotseha butle. Ka lebaka la ho hloka taolo ea hepatic, bophelo ba halofo bo bolelele ebile bioavailability ea eketseha. Tabeng ena, e le ho qoba ho bokellana ha moriana 'meleng oa bakuli ba joalo, lethal dose le lokela ho fokotsoa.

Mofumahali

Pentoxifylline e ntlafatsa likarolo tsa mali tsa rheological ka ho ama khaello ea methapo e khutsitseng ea lisele tse khubelu tsa mali, ho thibela ho kopana ha liplatelete le ho fokotsa phallo e phahameng ea mali. Mochine oa ts'ebetso oa pentoxifylline ho ntlafatsa likarolo tsa mali tsa rheological li kenyelletsa keketseho ea lisele tse khubelu tsa mali maemong a ATP (adenosine triphosphate), cAMP (cyclo-adenosine monophosphate) le li-cyclic nucleotide tse ling. Pentoxifylline e fokotsa haholo ponahalo ea plasma le mali ka ho fokotsa bongata ba fibrinogen. Ho fokotseha ho joalo ha mahloriso a fibrinogen ke litholoana tsa keketseho ea ketsahalo ea fibrinolytic le ho fokotseha ha mokhoa oa eona. Ntle le moo, ka ho thibela enzyme e kopantsoeng le membrane-phosphodiesterase enzymes (e lebisang keketseho ea khatello ea cAMP) le syntomboxane synthesis, pentoxifylline ka matla e thibela ho ikopanya le ho qobelloa ha liplatelete ka nako e ts'oanang e tsosa motsoako oa prostacyclin (prostaglandin I2).

Pentoxifylline e fokotsa tlhahiso ea li-interleukin ka li-monocytes le li-macrophages, tse fokotsang ho teba ha karabelo ea ho ruruha. Pentoxifylline e ntlafatsa phallo ea mali le phallo ea methapo, e eketsa khatello ea karoloana ea moea ea "oxygen" mesifeng ea ischemic e amehang maemong a tlase, ka har'a cortex ea "cerebral" le "fluid", "retina" ea bakuli ba nang le retinopathy.

Litlamorao

Tse latelang ke maemo a karabelo e mpe e etsahetseng nakong ea liteko tsa tleliniki le ka mor'a nako ea ho bapatsa.
Ho tsoa ho tsamaiso ea methapo ea pelo. Arrhythmia, tachycardia, angina pectoris, o fokotse khatello ea mali, o eketsa khatello ea mali.
Ho tsoa ho li-lymphatic system le sistimi ea mali. Thrombocytopenia, thrombocytopenic purpura, anemia ea aplasiki (karolo e itseng kapa e felletseng ea ho felisoa ha sebopeho sa lisele tsohle tsa mali), parytopenia, e ka bolaeang.
Ho tsoa tsamaisong ea methapo. Dizziness, hlooho, aseptic meningitis, ho thothomela, paresthesias, cramps.
Ho tsoa pampiring ea ka mpeng. Ho teneha ka mpeng, ho ferekana ha maikutlo ka mpeng, ho bata, ho nyekeloa, ho hlatsa kapa lets'ollo.
Karolong ea letlalo le lisele tse ling. Ho hlohlona, ​​bofubelu ba letlalo le urticaria, chefo e hlahisang chefo ea tsebetso le lefu la Stevens-Johnson.
Tlolo ea ts'ebetso ea methapo. Mofuthu oa mocheso (malakabe a chesang), ho tsoa mali, edema ea ho potoloha.
Ho tsoa ho sesole sa 'mele. Karabelo ea anaphylactic, liphetoho tsa anaphylactoid, angioedema, bronchospasm le makala a anaphylactic.
Karolong ea sebete le senya. Intrahepatic cholestasis.
Mathata a kelello Ho tsosa, ho khathatsa boroko, ho lora.
Karolong ea litho tsa pono. Ho senyeha hoa pono, conjunctivitis, hemorrhage ea morao, ho hema hape ka mokokotlong.
Ba bang. Ho tlalehiloe ka litaba tsa hypoglycemia, ho fufuleloa haholo le feberu.

Boimana

Ha ho na boiphihlelo bo lekaneng ka sethethefatsi sena Pentiline basali baimana. Ka hona, ha ho kgothaletswe ho fana ka Pentilin nakong ea kemolo.
Pentoxifylline ka likhahla tse nyane e fetela lebeseng la matsoele. Haeba Pentilin e laetsoe, emisa ho anyesa.

Ho sebelisana le lithethefatsi tse ling

Matla a ho theola tsoekere ea mali ka tlhaho ho li-insulin kapa li-antidiabetesic tsa molomo a ka ntlafatsoa. Ka hona, bakuli ba fumanang meriana ea lefu la tsoekere ba lokela ho betoa leihlo.
Nakong ea papatso ea morao-rao, linyeoe tsa ts'ebetso ea anticoagulant e ile ea tlalehoa ho bakuli ba ileng ba phekoloa ka nako e le 'ngoe ka pentoxifylline le anti-vithamine K. Ha dosing ea pentoxifylline e laetsoe kapa e fetotsoe, ho khothalletsoa ho lekola ts'ebetso ea anticoagulant sehlopheng sena sa bakuli.
Pentiline e ka ntlafatsa sephetho sa hypotensive sa lithethefatsi tse antihypertensive le lithethefatsi tse ling, tse ka lebisang ho fokotseha ha khatello ea mali.
Tšebeliso e tšoanang ea pentoxifylline le theophylline ho bakuli ba bang e ka lebisa ho eketseha ha litekanyetso tsa theophylline maling. Ka hona, ho khonahala ho eketsa khafetsa le ho eketsa lipontšo tsa liphetoho tse fapaneng tsa theophylline.
Ketorolac, meloxicam.
Tšebeliso e tšoanang ea pentoxifylline le ketorolac li ka lebisa ho eketseha ha nako ea prothrombin le ho eketsa monyetla oa ho tsoa mali. Monyetla oa ho tsoa mali o ka eketseha ka tšebeliso e tšoanang ea pentoxifylline le meloxicam. Ka hona, kalafo e tšoanang ka lithethefatsi tsena ha e khothalletsoe.

Bongata

Matšoao a pele a overdose e mpe Pentiline ho nyekeloa ke pelo, kizungu, tachycardia, kapa khatello ea mali e fokotsehileng.Ntle le moo, matšoao a kang feberu, ho hlohlona, ​​ho utloa mocheso (ho chesoa ke mocheso), ho lahleheloa ke kelello, areflexia, ho ts'oaroa ha tonic-clonic le ho hlatsa 'mala oa mabaka a kofi le tsona li ka ba le sesupo sa ho tsoa mali.
Phekolo. Bakeng sa ho phekola ho feta tekano le ho thibela ho hlaha ha mathata, ho hlokahala tlhokomelo e khethehileng le e khethehileng ea bongaka le ho amohela mekhoa ea kalafo.

Likarolo tsa ts'ebeliso

Ho matšoao a pele a karabelo ea anaphylactic / anaphylactoid, kalafo e nang le pentoxifylline e lokela ho khaoloa 'me e batle keletso ea bongaka.

Hlahlobo e hlokolosi ea bongaka e hlokahala bakeng sa bakuli ba pelo ea methapo ea pelo, methapo ea methapo ea methapo ea methapo, le coronary sclerosis, le ba bileng le lefu la pelo kapa ho buuoa.

Tabeng ea pentoxifylline, bakuli ba nang le lefu la pelo le sa foleng ba lokela ho fihla pele molemong oa puseletso ea mali.

Bakeng sa bakuli ba nang le systemic lupus erythematosus (SLE) kapa lefu le kopaneng la tishu, pentoxifylline e ka fuoa feela kamora tlhahlobo e phethahetseng ea likotsi le melemo.

Ka lebaka la kotsi ea hemorrhage ka ts'ebeliso e ts'oanang ea pentoxifylline le anticoagulants ea molomo, ho hlahlojoa ka hloko le ho lekola khafetsa litekanyetso tsa coagulation tsa mali (tekanyetso e tloaelehileng ea machabeng (MES)).

Kaha ho na le monyetla oa ho ba le phallo ea mali ea "aplasic" nakong ea kalafo ka pentoxifylline, ho hlokahala tlhahlobo e akaretsang ea tlhahlobo ea mali ka kakaretso.

Ho bakuli ba nang le lefu la tsoekere le ba fumanang kalafo ka li-insulin kapa li-agent tsa hypoglycemic tsa molomo, ka tšebeliso ea litekanyetso tse phahameng tsa pentoxifylline, hoa khoneha ho eketsa litlamorao tsa lithethefatsi tsena tsoekere ea mali (bona Karolo "Ho sebelisana le lithethefatsi tse ling le mefuta e meng ea litšebelisano").

Ho bakuli ba nang le ho se sebetse hantle ke lefu la mokokotlo (phelloxifylline excretion) e kanna ea lieha ho bakuli ba nang le bothata ba ho phekoloa ke lefu la masapo. Ho beha leihlo ka nepo hoa hlokahala.

Bakuli ba nang le bothata ba ho phekoloa ka methapo. Bakeng sa bakuli ba nang le bothata ba ho phekoloa ke lefu la mokokotlo (phumano ea tumellano e tlase ho 30 ml / min), tekanyetso ea tekanyetso ho fihla ho 50-70% ea tekanyetso e tloaelehileng e lokela ho etsoa ka lebaka la mamello e le 'ngoe, mohlala, ts'ebeliso ea pentoxifylline 400 mg makhetlo a 2 ka letsatsi ho fapana le 400 mg makhetlo a 3 ka letsatsi.

Bakuli ba nang le khatello e matla ea sebete. Bakeng sa bakuli ba nang le bothata ba ho se sebetse hantle ka matla ho sebete, qeto ea ho fokotsa tekanyetso e lokela ho etsoa ke ngaka, ho nahanela ho teba ha lefu lena le mamello ho mokuli ka mong.

Ho shebisisa ka kotloloho ho hlokahala bakeng sa:

  • bakuli ba nang le pelo e ngata ea methapo ea pelo,
  • bakuli ba nang le myocardial infarction
  • bakuli ba nang le arterial hypotension,
  • bakuli ba nang le atherosulinosis e matla ea methapo ea methapo le ea pelo, haholo-holo e nang le khatello ea methapo ea methapo le methapo ea pelo. Ho bakuli bana, ka ts'ebeliso ea lithethefatsi, litlhaselo tsa angina, arrhythmias le arterial hypertension lia khoneha,
  • bakuli ba nang le bothata ba ho phekoloa ka methapo (imvume ea tumello ea "creatinine ka tlase ho 30 ml / min.),"
  • bakuli ba nang le bothata bo matla ba sebete,
  • bakuli ba nang le ts'oaetso e phahameng ea ho tsoa mali, e bakiloeng, ka mohlala, ka kalafo ka li-anticoagulants kapa mathata a amanang le mali. Bakeng sa ho tsoa mali - bona karolo "Contraindication",
  • bakuli ba nang le nalane ea lisele tsa ka mpeng le tsa duodenal, bakuli ba sa tsoa feta ba sebelisitsoe kalafo ea bongaka e sebelisang (kotsi e eketsehileng ea ho tsoa mali, e hlokang ho shebeloa ka mokhoa o hlophisehileng oa maemo a hemoglobin le hematocrit)
  • bakuli ba tšoaroang ka nako e tšoanang le bahanyetsi ba pentoxifylline le vithamine K (bona karolo e reng "Ho sebelisana le lithethefatsi tse ling le mefuta e meng ea litšebelisano"),
  • bakuli ba fumanang kalafo ka nako e le ngoe le li-pentoxifylline le li-agents tsa hypoglycemic (bona karolo "Ho sebelisana le lithethefatsi tse ling le mefuta e meng ea litšebelisano").

Sebelisa nakong ea bokhachane le pelehi

Kaha ha ho na boiphihlelo bo lekaneng ka tšebeliso ea pentoxifylline ho basali baimana, ha ea lokela ho beoa nakong ea kemolo.

Nakong ea lebone, pentoxifylline e fetela lebese la matsoele. Leha ho le joalo, lesea le amohela lintho tse fokolang feela. Ka hona, ha ho na monyetla oa hore ts'ebeliso ea pentoxifylline nakong ea ho anyesa e bontšoa hore e na le phello e itseng ho lesea.

Bokhoni ba ho susumetsa sekhahla sa karabelo ha ho khanna likoloi kapa mekhoa e meng

Pentilin ha e na matla a ho khanna koloi le mekhoa e meng. Leha ho le joalo, ho bakuli ba bang ho ka baka tsitsipano, ka hona, ka tsela e sa tobang, fokotsa bokhoni ba psychophysical ba ho khanna koloi le mekhoa e meng. Ho fihlela bakuli ba tseba hore na ba arabela kalafong joang, ha ba eletsoe ho khanna koloi kapa ho sebetsa ka mekhoa e meng.

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