Gliclazide MV: litaelo tsa tšebeliso, li-analogues le litlhahlobo, litheko tsa meriana ea litlama ea Russia

Gliclazide MV ke moemeli oa hypoglycemic bakeng sa kalafo ea lefu la tsoekere la mofuta oa 2. Ntho e sebetsang ke Gliclazide.

Moemeli oa hypoglycemic ea molomo, e fumanoang molokong oa bobeli. E hlohlelletsa secretion ea insulin ke lisele tsa β-tsa manyeme.

Setlhare se eketsa kutloelo-bohloko ea lisele tse kenellang ho insulin, se tsosetsa ts'ebetso ea li-enzymes tse kenang (haholoholo, mesifa ea glycogen synthetase). Fokotsa nako ea ho qalella ho tloha motsotso oa ho ja ho isa ho qala ho secretion. E khutlisa tlhoro ea pele ea "insulin secretion", e fokotsa tlhoro ea "hyperglycemia" ea postprandial.

Gliclazide MV e fokotsa khokahano ea liplatelete le ho kopana, e liehisa nts'etsopele ea "parietal thrombus", 'me e eketsa ts'ebetso ea methapo ea methapo. Normalizing ho hlaphoheloa ha methapo ea pelo.

Lowers cholesterol ea mali (Cs) le Cs-LDL
E eketsa mahloriso a HDL-C,
Fokotsa li-radicals tsa mahala.
E thibela nts'etsopele ea micothrombosis le atherosclerosis.
E ntlafatsa microcirculation.
E fokotsa kutloisiso ea methapo ho adrenaline.

Ka lefu la tsoekere le lefu la tsoekere le tšebeliso ea nako e telele, ho na le phokotseho e kholo ea proteinuria.

Ha u fana ka litlhare, taolo e matla ea glycemic e na le melemo e kholo e sa khethoang ke liphetho tsa kalafo ka litlhare tsa antihypertensive.

Sebopeho sa Gliclazide MV (Letlapa le le leng):

Lintho tse sebetsang: gliclazide - 30 kapa 60 mg,
Likarolo tse thusang: hypromellose - 70 mg, colloidal silicon diode - 1 mg, cellcrystalline cellulose - 98 mg, magnesium stearate - 1 mg.

Matšoao a ho sebelisoa

Ke eng e thusang Gliclazide MV? Ho ea ka litaelo, sethethefatsi bakeng sa kalafo ea boima bo feteletseng ba mofuta oa 2 lefu la tsoekere (e sa itšetlehang ka insulin) ka lipontšo tsa pele tsa lefu la tsoekere la lefu la tsoekere.

E boetse e sebelisoa bakeng sa thibelo ea mathata a microcirculatory, e le karolo ea kalafo e rarahaneng, ka nako e ts'oanang le tse ling tse tsoang ho sulfonylurea.

Litaelo tsa ho sebelisoa Gliclazide MV (30 60 mg), litekanyetso

Moriana o nooa ka molomo metsotso e 30 pele ho lijo.

Tekanyetso ea letsatsi le letsatsi e khothalletsoang ea Gliclazide MV ke 80 mg e khothalletsoang ke litaelo bakeng sa tšebeliso; haeba ho hlokahala, e nyolohela ho 160-320 mg ho tekanyetso e 2 e arohaneng.

Ho nona ka bonngoe ho latela ho itima lijo ha glycemia le lihora tse peli kamora ho ja, le lipontšo tsa lefu lena.

Haeba u fetoa ke tekanyetso, u ke ke ua nka tekanyetso e habeli. Ha o nkela sethethefatsi se seng sa hypoglycemic, ha ho hlokahale nako ea phetoho - Gliclazide MB e qala ho nkuoa ka le hlahlamang.

Mohlomong motsoako le li-biguanides, insulin, alpha-glucosidase inhibitors. Ha e le bonolo le ho leka-lekana ho hlaba ha a liphooko, ho fanoa ka tekanyetso e tšoanang.

Ho bakuli ba kotsing ea hypoglycemia, ho sebelisoa lethal e fokolang.

Litaelo tse khethehileng

Molemong oa kalafo ea mellitus e sa itšetleheng ka insulin, moriana o lokela ho sebelisoa ka nako e le ngoe le lijo tse nang le khalori e tlase tse nang le lik'habohaedreite tse tlase.

Nakong ea kalafo, o hloka ho lekola khafetsa ho feto-fetoha ha letsatsi le letsatsi ka litekanyetso tsa tsoekere, hammoho le boemo ba tsoekere maling maling ka mpeng e se nang letho le ka mor'a ho ja.

Litlamorao

Taelo e hlokomelisa ka monyetla oa ho nts'etsapele litla-morao tse latelang ha u fana ka taelo ea Gliclazide MV:

Ho nyekeloa ke pelo, ho hlatsa, bohloko ba ka mpeng,
Thrombocytopenia, erythropenia, agranulocytosis, hemolytic anemia,
Allergic vasculitis,
Letlalo la letlalo, ho hlohlona,
Ho hloleha ha sebete
Ho sitisoa ha pono
Hypoglycemia (e nang le overdose).

Contraindication

Glyclazide MV e hanyetsanoe maemong a latelang:

Mofuta oa 1 oa lefu la tsoekere:
Ketoacidosis
Lefu la tsoekere le letala
Ho kula ho matla le ho senyeha ho matla,
Hypersensitivity ho sulfonylureas le sulfonamides.
Ts'ebeliso e tšoanang ea gliclazide le imidazole derivatives (ho kenyelletsa miconazole).

E laetsoe ka hloko ho batho ba tsofetseng, ka ho ja ka mokhoa o sa tloaelehang, hypothyroidism, hypopituitarism, lefu le tebileng la methapo ea methapo le lefu le matla la mokokotlo, ho hloka kalafo ea adrenal, kalafo ea nako e telele le glucocorticosteroids.

Bongata

Matšoao a feteletseng a bonahatsoa ke hypoglycemia - hlooho, mokhathala, ho fokola haholo, ho fufuleloa, ho tsitsipana, ho teneha, ho teneha, ho lieha ho arabela, pono e sa sebetseng le puo, ho tsitsipana, ho tsekela, ho ferekana.

Ka hypoglycemia e leka-lekaneng ntle le ho lemala ho sa foleng, fokotsa tekanyetso ea lithethefatsi kapa eketsa bongata ba lik'habohaedreite tse fanoang ke lijo.

Haeba ho tšoaroa ke komello ea hypoglycemic kapa ho belaelloa, 50 ml ea tharollo ea glucose ea 40% (dextrose) e lokela ho kenella (kahare). Kamora moo, tharollo ea 5% ea dextrose e kenngoa kahare, e u lumellang ho boloka khatello ea mali e hlokahalang maling (e ka ba 1 g / l).

Khokahano ea tsoekere ea mali e lokela ho beoa leihlo ka hloko 'me mokuli o lokela ho lula a beiloe leihlo bakeng sa bonyane matsatsi a 2 kamora ho ba le ts'oaetso e feteletseng.

Tlhoko ea ho shebella mesebetsi ea mantlha ea mokuli e khethoa le ho feta ke boemo ba hae.

Kaha ntho e sebetsang e amana haholo le liprotheine tsa plasma, dialysis ha e na thuso.

Analogs Glyclazide MV, theko ea meriana

Haeba ho hlokahala, u ka kenya sebaka sa Gliclazide MV ka analogue ka mokhoa oa kalafo - tsena ke lithethefatsi:

Ha u khetha li-analogues, ho bohlokoa ho utloisisa hore litaelo tsa tšebeliso ea Glyclazide MV, theko le litekolo, ha li sebetse lithethefatsing ka mokhoa o ts'oanang. Ho bohlokoa ho fumana tlhahlobo ea ngaka le ho se etse phetoho e ikemetseng ea lithethefatsi.

Theko ea meriana ea litlama ea Russia: Matlapa a Glyclazide MV 30 mg 60 - ho tloha ho li-ruble tse 123 ho isa ho tse 198, matlapa a Glyclazide MV 60 mg 30 - ho tloha ho 151 ho isa ho 210 li-ruble, ho latela li-pharmacies tse 471.

Boloka sebakeng se lefifi, se hole le bana ka mocheso ho fihlela 25 ° C. Bophelo ba Shelf ke lilemo tse 3.

Thutela-litso

E eketsa secretion ea insulin ka lisele tsa pancreatic beta mme e ntlafatsa ts'ebeliso ea tsoekere. E susumetsa ts'ebetso ea mesifa ea glycogen synthetase. E sebetsang ho metabolism ea lefu la tsoekere la metabolic, ho bakuli ba nang le botenya ba molao-motheo. E tloaetse boemo ba glycemic kamora matsatsi a 'maloa a kalafo. E fokotsa sekhahla sa nako ho tloha motsotso oa ho ja ho fihlela qalong ea secretion ea insulin, e khutlisa tlhoro ea pele ea insulin le ho fokotsa hyperglycemia e bakoang ke ho ja lijo. E ntlafatsa methapo ea hematological, mali a rheological a mali, heestasis le sistimi ea microcirculation. E thibela nts'etsopele ea microvasculitis, ho kenyelletsa ho ruruha hoa leihlo. E hatella pokello ea liplatelete, e eketsa haholo index ea ho se lumellane e amanang le eona, e eketsa mosebetsi oa heparin le fibrinolytic, e eketsa mamello ea heparin. E bonts'a thepa ea antioxidant, e ntlafatsa conjunctival vascularization, e fana ka phallo ea mali e tsoelang pele ho li-microvessels, e tlosa lipontšo tsa microstasis. Ka lefu la tsoekere, "proteinuria" ea fokotsoa.

Litekong tse ithutoang tsa mefuta e sa foleng le e tobileng ea chefo, ha ho na matšoao a ho ts'oaroa ke lefutso, mutagenicity le teratogenicity (likhoto, le mebutlanyana) hammoho le litlamorao ho tsoalo (likhoto).

Ka mokhoa o phethahetseng le o potlakileng o tsoang ho tšilo ea lijo, C_max e fumaneha ka mor'a lihora tse 2-6 (bakeng sa litafole tse nang le tokiso e fetotsoeng - kamora lihora tse 6-12) kamora tsamaiso. Khakanyo ea plasma e lekanang e thehiloe kamora matsatsi a mabeli. Ho kopanya liprotheine tsa plasma ke 85-99%, palo ea phetisetso ke 13–24 l. Nako ea ts'ebetso ka tekanyetso e le 'ngoe e fihla lihora tse 24 (bakeng sa litafole tse nang le tokollo e fetotsoeng - lihora tse fetang 24). Sebeteng, e kenella ka har'a oxidation, hydroxylation, glucuronidation ha ho etsoa metsoako e 8 e sa sebetseng, e 'ngoe ea eona e nang le phello e matla ho microcirculation. E tšeloa ka sebopeho sa metabolites ka moroto (65%) le ka tšilo ea lijo (12%). T_1/2 - lihora tse 8-12 (bakeng sa litafole tse nang le tokollo e fetotsoeng - lihora tse ka bang 16).

Litlamorao tsa ntho ena Glyclazide

Ho tsoa ho tšilo ea lijo: ka seoelo - matšoao a dyspeptic (ho nyekeloa, ho hlatsa, bohloko ba ka mpeng), ka seoelo - jaundice.

Ho tsoa ho tsamaiso ea pelo le mali: cytopenia e feto-fetohang, eosinophilia, anemia.

Ka lehlakoreng la letlalo: ka seoelo - karabelo ea letlalo le lintho tse ka u sitisang ho etsa joalo.

Ka lehlakoreng la metabolism: hypoglycemia

Ho tsoa ho tsamaiso ea methapo ea kutlo le litho tsa kutlo: bofokoli, hlooho e opang, ho tsekela, phetoho ka tatso.

Tšebelisano

Phello e leng keketseho ea Ace inhibitors, anabolic steroid, beta-blockers, fibrates, biguanides, chloramphenicol, cimetidine, coumarin, fenfluramine, fluoxetine, salicylates, guanethidine, Mao inhibitors, miconazole, fluconazole, pentoxifylline, theophylline, phenylbutazone, phosphamide, tetracyclines.

Li-Barbiturates, chlorpromazine, glucocorticoids, sympathomimetics, glucagon, saluretics, rifampicin, lihomone tsa qoqotho, letsoai la lithium, litekanyetso tse phahameng tsa acid ea nicotinic, lithibela-pelehi tsa molomo le estrogens - li fokolisa hypoglycemia.

Bongata

Matšoao maemo a hypoglycemic, ho fihlela ho koma, edema ea 'mele.

Phekolo: ho kenella ha tsoekere ka hare, haeba ho hlokahala - ka / ts'ebetsong ea tharollo ea glucose (50%, 50 ml). Ho hlokomela glucose, nitrojene ea urea, li-electrolyte tsa serum. Ka lefu la mokokotlo - mannitol (iv), dexamethasone.

Tlhokomelo Glyclazide

Nakong ea khetho ea lethal dose, haholo ha e kopantsoe le kalafo ea insulin, hoa hlokahala ho tseba boemo ba tsoekere le matla a glycemia, molemong oa ho lekola maemo a tsoekere ea mali kamehla. Bakeng sa thibelo ea hypoglycemia, ho hlokahala hore ho lumellane ka ho hlaka le ho ja lijo, ho qoba ho bolaoa ke tlala le ho tlohela ho sebelisa joala ka ho felletseng. Tšebeliso e tšoanang ea ba beta-blockers e ka pata matšoao a hypoglycemia. Ho khothalletsoa ho ja lijo tse bobebe tsa carb e tlaase. Sebelisa ka hlokolosi ha u ntse u sebeletsa bakhanni ba likoloi le batho bao mosebetsi oa bona o amanang le tlhokomelo e eketsehileng.

Sokolla foromo le sebopeho

Gliclazide MV e hlahisoa ka mokhoa oa matlapa a nang le tlhahiso e fetotsoeng: cylindrical, biconvex, e tšoeu e nang le tranelate e tsoekere kapa e tšoeu, ho ts'oaroa ho fokolang hoa khoneha (likotoana tsa 10, 20 kapa 30 ka har'a li-package tsa aluminium kapa polyvinyl chloride cell, 1, 2, 3, 4, 5, 6, 10 liphutheloana ka lebokoseng la karete ea likarete, 10, 20, 30, 40, 50, 60, kapa li-pcs tse 100. Likoteng tsa polasetiki, 1 a ka kenya mekotla ea likarete).

Moetso oa Letlapa le le leng o kenyelletsa:

Lintho tse sebetsang: gliclazide - 30 mg,
Likarolo tse thusang: hypromellose - 70 mg, colloidal silicon diode - 1 mg, cellcrystalline cellulose - 98 mg, magnesium stearate - 1 mg.

Mofumahali

Glyclazide ke sulfonylurea derivative e nang le thepa ea hypoglycemic mme e etselitsoe tsamaiso ea molomo. Phapang ea eona ho lithethefatsi tse sehlopheng sena ke ho ba teng ha reng e nang le heterocyclic e nang le N e nang le endocyclic bond.

Gliclazide e fokotsa tsoekere ea mali, e ba e khothalletsang tlhahiso ea insulin ke lisele tsa beta tsa lihlekehleke tsa Langerhans. Keketseho e eketsehileng ea C-peptide le insulin ea postprandial e phehella kamora lilemo tse peli tsa kalafo. Joalo ka litokollo tse ling tsa sulfonylurea, phello ena e bakoa ke karabelo e matla haholoanyane ea cells lisele tsa lihlekehleke tsa Langerhans ho susumetsa tsoekere, tse entsoeng ho latela mofuta oa mmele. Gliclazide ha e ame metabolism ea carbohydrate feela, empa e baka le litlamorao tsa hemovascular.

Ho bakuli ba nang le mofuta oa lefu la tsoekere la mofuta oa 2, gliclazide e thusa ho khutlisa tlhako ea pele ea "insulin", e leng sephetho sa tšebeliso ea glucose hape e tsosa mohato oa bobeli oa insulin secretion. Keketseho e kholo ea motsoako oa insulin e amahanngoa le karabelo ho susumetso e bakoang ke tsoekere kapa tšebeliso ea lijo.

Ts'ebeliso ea gliclazide e fokotsa kotsi ea ho ba le ts'oaetso ea methapo e nyane ea mali ka ho etsa lintho tse ka qholotsang nts'etsopele ea mathata ho bakuli ba nang le lefu la tsoekere, ho fokotseha ha litaba tsa ts'ebetso ea liplatelete (thromboxane B)₂, beta-thromboglobulin), thibelo e sa lekanyetsoang ea khokahanyo ea liplatelete le ho kopana, hammoho le ho ama ho tsosolosoa ha ts'ebetso ea ts'ebetso ea fibrinolytic le vasotine endothelium, le ts'ebetso e eketsehileng ea plasminogen, e leng activator ea lithane.

Ts'ebeliso ea glycazide e fetotsoeng, sepheo sa glycosylated hemoglobin (HbAlc) se ka tlase ho 6.5%, ka taolo e matla ea glycemic ho latela liteko tse tšepahalang tsa tleliniki, e ka fokotsa kotsi ea mathata a mantlha a lefu la tsoekere la 2 ha a bapisoa le glycemic ea setso. taolo.

Ts'ebetso ea taolo e matla ea glycemic e kenyelletsa ho hlahisa gliclazide (tekanyetso e tloaelehileng ea letsatsi le letsatsi ke 103 mg) mme e eketsa tekanyetso ea eona (ho fihlela ho 120 mg ka letsatsi) ha e nka thupelo e tloaelehileng ea bongaka morao (kapa ho e-na le eona) pele e e tlatselletsa ka moriana o mong oa hypoglycemic (mohlala, insulin, metformin thiazolidinedione derivative, alpha glucosidase inhibitor). Ts'ebeliso ea gliclazide sehlopheng sa bakuli ba tlisoang ke taolo ea glycemic e matla (ka karolelano, boleng ba HbAlc e ne e le 6.5% mme nako ea ho shebella e ne e le lilemo tse 4,8), ha e bapisoa le sehlopha sa bakuli ba tlas'a taolo e tloaelehileng (boleng ba HbAlc bo boholo e ne e le 7.3% ), e netefalitse hore menyetla e lekanyelitsoeng ea liketsahalo tse kopaneng tsa mathata a maholo le a maholo ka bongata e fokotseha haholo (ka 10%) ka lebaka la phokotso e kholo ea menyetla ea ho ba le mathata a maholo (a 14%), linako Itijah le letotong la microalbuminuria (9%), mathata renal (11%), ho qala le letotong la nephropathy (21%), le ntshetsopele ya macroalbuminuria (30%).

Ha ho fana ka gliclazide, taolo e matla ea glycemic e na le melemo ea bohlokoa e sa khethoang ke liphetho tsa kalafo ka lithethefatsi tsa antihypertensive.

Mofumahali

Kamora ho tsamaisoa ka molomo, glycoside e kenella kahare ho tšilo ea lijo ka 100%. Likahare tsa eona ho plasma ea mali li eketseha butle butle ka lihora tse 6 tsa pele, 'me khatello ea maikutlo e lula e tsitsitse bakeng sa lihora tse 6-12. Tekanyo kapa tekanyo ea ho kenngoa ha gliclazide e ikemetse ka har'a lijo.

Hoo e ka bang 95% ea ntho e sebetsang e tlama liprotheine tsa plasma. Bophahamo ba kabo ea thepa e ka ba lilithara tse 30. Kamohelo ea Gliclazide MV ka tekanyetso ea 60 mg hang ka letsatsi eu lumella ho boloka khatello ea kelello ea gliclazide e plasma ea mali ka lihora tse 24 kapa ho feta.

Gliclazide metabolism e hlaha haholo-holo ka har'a sebete. Li-metabolites tsa metabolism tsa ntho ena ho plasma ha li khethoe. Gliclazide e epolloa haholo-holo ka liphio ka sebopeho sa metabolites, e batlang e le 1% e sibollotsoe e sa fetohe ka har'a moroto. Bophara ba halofo ea bophelo ke lihora tse 16 (sesupo se ka fapana ho tloha ho lihora tse 12 ho isa ho tse 20).

Kamano e nepahetseng e ne e tlalehiloe lipakeng tsa tekanyetso e amohelang ea lithethefatsi (e sa feteng 120 mg) le sebaka se tlas'a motsoako oa pharmacokinetic "nako -". Ho bakuli ba tsofetseng, ha ho na liphetoho tse kholo tsa kliniki maemong a pharmacokinetic.

Contraindication

Mofuta oa 1 oa lefu la tsoekere:
Mathata a matla a amang sebete le a liphio,
Ketoacidosis
Lefu la tsoekere le letala
Tšebeliso e kopanetsoeng le li-derivatives tsa imidazole (ho kenyeletsoa miconazole),
Hypersensitivity ho sulfonamides le sulfonylureas.

Ts'ebeliso ea Glyclazide MV ha e khothalletsoe basali ba mokhachane le baimana.

Litaelo tsa ho sebelisa Gliclazide MV: mokhoa le litekanyetso

Gliclazide MV e nooa ka molomo pele ho lijo.

Mokokotlo oa ho sebelisa lithethefatsi ke makhetlo a 2 ka letsatsi.

Ngaka e beha tekanyetso ea letsatsi le letsatsi ka bomong, ho ipapisitse le lipontšo tsa kliniki le lefu la glycemia, ka mpeng e se nang letho le lihora tse peli ka mor'a lijo.

Joaloka molao, tekanyetso ea pele ke 80 mg ka letsatsi, tekanyetso e tloaelehileng ke 160-320 mg ka letsatsi.

Litaelo tse khethehileng

Molemong oa kalafo ea "mellitus" e sa itšetleheng ka insulin, Gliclazide MV e lokela ho sebelisoa ka nako e ts'oanang le lijo tse nang le khalori e tlase tse nang le lik'habohaedreite tse tlase.

Ka ts'ebetso ea ho buuoa kapa ho bolaoa ha lefu la tsoekere mellitus, monyetla oa ho sebelisa litokisetso tsa insulin o lokela ho nahaneloa.

Tabeng ea hypoglycemia, haeba mokuli a le hlokolosi, glucose (kapa tharollo ea tsoekere) e lokela ho sebelisoa ka molomo. Maemong a tahlehelo ea kelello, glucose (intravenously) kapa glucagon (subcutanely, intramuscularly kapa intravenously) e lokela ho tsamaisoa. Bakeng sa ho qoba nts'etsopele ea hypoglycemia kamora ho khutlisetsa tsebo, mokuli o lokela ho fuoa lijo tse nang le lik'habohaedreite tse ngata.

Tšebeliso e tšoanang ea gliclazide e nang le cimetidine ha e khothalletsoe.

Ka tšebeliso e kopaneng ea gliclazide e nang le verapamil, ho hlokahala hore ho be leihlo leihlo la tsoekere maling maling ka acarbose, ho lekola ka hloko le ho khalemela litekanyetso tsa litekanyetso tsa li-hypoglycemic agents.

Tšusumetso ho bokhoni ba ho khanna makoloi le mekhoa e rarahaneng

Bakuli ba nkang Glyclazide MV ba lokela ho hlokomela matšoao a ho ba teng ha hypoglycemia mme ba lemosoe ka tlhoko ea ho ba hlokolosi ha u ntse u khanna kapa o etsa mesebetsi e meng e hlokang karabelo ea psychomotor hang-hang, haholo qalong ea kalafo.

Bokhachane le pelehi

Ha ho na boiphihlelo ka ho khethoa ha Gliclazide MV ho basali baimana. Boithuto ho liphoofolo bo tiisitse ho ba teng hoa litlamorao tsa phello ea ntho ena. Ka puseletso e sa lekaneng ea lefu la tsoekere nakong ea kalafo, ho na le menyetla e eketsehang ea ho ba le mathata a amanang le tlhaho ka pōpelong, a ka fokotsoang ke taolo e lekaneng ea glycemic. Sebakeng sa gliclazide ho basali baimana, ho khothalletsoa ho sebelisa insulin, eo hape e leng lithethefatsi tsa khetho ho bakuli ba rerileng ho ima, kapa ba baimana nakong ea kalafo le Gliclazide MV.

Kaha ha ho na tlhahisoleseling mabapi le tšebeliso ea motsoako o sebetsang oa moriana lebese la matsoele, 'me ho masea a sa tsoa hlaha ho na le menyetla e eketsehileng ea ho ba le neonatal hypoglycemia, ho nka Gliclazide MB nakong ea lebactation e hanyetsanoa.

Ho sebelisana le lithethefatsi

Ka tšebeliso e kopaneng ea Gliclazide MV e nang le lithethefatsi tse ling, litlamorao tse sa rateheng li ka hlaha:

Li-derivatives tsa Pyrazolone, salicylates, phenylbutazone, antibacterial sulfonamides, theophylline, caffeine, monoamine oxidase inhibitors (MAOs): tšibollo ea phello ea hypoglycemic ea glyclazide,
Batho ba sa ikhetheng beta-blockers: monyetla o eketsehileng oa hypoglycemia, mofufutso o eketsehang le maske oa tachycardia le ho thothomela ha matsoho ke tšobotsi ea hypoglycemia,
Gliclazide le acarbose: phello e matla ea hypoglycemic,
Cimetidine: plasma gliclazide concentration (hypoglycemia e kholo e ka hlaha, e bonts'oa ka sebopeho sa khatello ea maikutlo le methapo e kholo ea kelello),
Glucocorticosteroids (ho kenyelletsa le mefuta ea litekanyetso tsa kantle), diuretics, barbiturates, estrogens, progestin, lithethefatsi tse kopaneng tsa estrogen-progestogen, diphenin, rifampicin: ho fokotseha hoa phello ea hypoglycemic ea glycazide.

Litšoantšiso tsa Gliclazide MV ke: Gliclazide-Akos, Glidiab, Glidiab MV, Glucostabil, Diabeteson MV, Diabefarm MV, Diabinax, Diabetalong.

Tlhahlobo ho Gliclazide MV

Gliclazide MV ke ea sehlahisoa sa sulfonylurea molokong oa bobeli mme e bontšoa ke ho teba ha ketso ea hypoglycemic, e hlalositsoeng ke tumellano e phahameng ea li-receptors tsa β-cell (makhetlo a 2-5 ho feta a molokong o fetileng oa lithethefatsi). Thepa ena e u lumella ho fihlella phello ea kalafo e nang le tekanyetso e fokolang mme e nyenyefatse palo ea likarabelo tse bohloko.

Ho latela maikutlo, MV Gliclazide e sebelisoa bakeng sa mathata a lefu la tsoekere (retinopathy, nephropathy ka ho ba le bothata ba ho hlaphoheloa ba 'mele bo sa feleng "angiopathy"). Sena se tlaleheloa ke bakuli ba falliselitsoeng ho amohela moriana ona. Sena se bakoa ke taba ea hore e 'ngoe ea li-metabolite tsa glycazide e ama haholo microcirculation, e fokotsa botebo ba angiopathy le kotsi ea ho ba le mathata a microvascular (nephropathy le retinopathy). Ka nako e ts'oanang, phallo ea mali ho conjunctiva le eona ea ntlafala le stasis ea methapo e nyamela.

Litsebi tse ngata li hatella hore nakong ea kalafo le Gliclazide MV, hoa hlokahala ho qoba ho bolaoa ke tlala le ho khetha lijo tse nang le lik'habohaedreite tse ngata. Ho seng joalo, khahlanong le semelo sa lijo tse tlase tsa khalori le ka mor'a ho ikoetlisa haholo 'meleng, mokuli a ka ba le hypoglycemia. Ka khatello ea maikutlo, ho hlokahala hore ho fetotsoe tokiso ea tekanyetso. Ho bakuli ba bang, kamora ho noa joala nakong ea kalafo le Gliclazide MV, matšoao a hypoglycemia le 'ona a ile a bonoa.

Gliclazide MV ha e khothalletsoe hore e sebelisoe ho bakuli ba tsofetseng ba nang le monyetla oa ho ba le hypoglycemia, ka hona, ketsahalong ena, ho loketse ho sebelisa lithethefatsi tse khutšoane.

Bakuli ba hlokomela bonolo ba ho sebelisa gliclazide ka mokhoa oa matlapa a lokolotsoeng a ntlafalitsoeng: ba sebetsa butle butle, 'me karolo e sebetsang e ajoa ka hohle-hohle' meleng. Ka lebaka la sena, moriana o ka nooa nako e le 'ngoe ka letsatsi,' me tekanyetso ea eona ea kalafo e ka tlase ho makhetlo a 2 ho feta ea gliclazide e tloaelehileng. Ho boetse ho na le litlaleho tsa hore ka kalafo ea nako e telele (lilemo tse 3-5 ho tloha qaleho ea tsamaiso), bakuli ba bang ba ile ba hanyetsa, e leng se neng se hloka hore ho be le lithethefatsi tse ling tse fokotsang tsoekere.

Tekanyetso le tsamaiso

Tekanyetso e itseng ea lithethefatsi e khethoa ke ngaka e eang. Ka nako e ts'oanang, lilemo tsa mokuli, ho ba teng le botebo ba matšoao a lefu lena, le boemo ba ho itima lijo ha glycemia le lihora tse peli kamora ho ja, li nkuoa hloko.

Ho latela litaelo tsa Gliclazide, tekanyetso ea pele ea letsatsi le letsatsi ke 80 mg, karolelano ke 160 mg, palo e phahameng e lumelletsoeng ke 320 mg. Moriana o lokela ho nooa habeli ka letsatsi metsotso e 30-60 pele ho lijo.

Tekanyetso ea pele ea MV Glyclazide ke 30 mg. Haeba phello ea kalafo e sa lekana hoo e ka bang libeke tse ling le tse ling tse peli, litekanyetso li ka eketsoa butle-butle hore e be lethal dose e kholo ea letsatsi le letsatsi ea li-120 mg (matlapa a 4).