Mokhoa oa ho sebelisa lithethefatsi Biosulin?
Lithethefatsi li na le mefuta e meraro ea litekanyetso:
- Tharollo ea ente Biosulin P,
- Ho emisoa bakeng sa tsamaiso ea Biosulin N,
- Ho emisoa bakeng sa tsamaiso ea sc ea Biosulin 30/70.
Millilita e le 'ngoe ea ente e na le 100 IU ea li-insulin tse entsoeng ka liphatsa tsa lefutso, hammoho le likarolo tse thusang tse kang metsi a ente, metacresol le glycerol.
Millilitara e le 'ngoe ea ho emisoa ha Biosulin N e na le 100 IU ea ntho e sebetsang le tse ling tse eketsehileng: zinc oxide, sodium hydrogen phosphate, protamine sulfate, crystalline phenol, metacresol, glycerol, ente ea metsi.
Millilita e le 'ngoe ea 30/70 ea ho emisoa e na le motsoako oa li-insulin tsa durations tse fapaneng tsa ts'ebetso (e khutsoanyane le e mahareng): insulin ea insulle ea motho le isofaninsulin ea motho ka karolelano ea 30:70.
Lokolla liforomo le sebopeho
Biosulin P ka ho qala ha ts'ebetso ea eona kapele e etsoa ka mokhoa oa tharollo ea liente. 1 cm³ e na le 100 IU ml ea insulin e hlahisitsoeng ka ho sebelisa theknoloji ea enjene ea genetic. Ntle le moo, motsoako oa moriana o kenyelletsa glycerin, metacresol le metsi a khethehileng a ente. Ampoules e ka bongata ba mefuta e mengata ea li-contour.
Ketso ea nako e mahareng ea Biosulin H e etsoa ka mokhoa oa ho emisoa ka ente tlas'a letlalo. E tšoeu, e behiloe hanyane nakong ea polokelo. E khutlisoa habonolo nakong ea motsamao o sisinyehang.
Ketso ea pharmacological
Hormone e sebetsa le li-insulin tse amohelang lisele, ka lebaka leo tokiso ea tsoekere ea mali e fihlellehang. Lits'ebetso tsa ho monya eona le metabolism ea methapo lia kenngoa, ho etsoa ha glycogen, 'me tlhahiso ea tsoekere liseleng tsa sebete ea fokotseha.
Ho qala hoa ts'ebetso ea Biosulin ea nako e telele ho tloha lihora tse 1 ho isa ho tse peli. Phello e kholo ka ho fetisisa e etsahala kamora lihora tse 6-12, mme nako eohle ea tšebetso e fihlile ho lihora tse 24.
Hormone e sebetsa le li-insulin tse amohelang lisele, ka lebaka leo tokiso ea tsoekere ea mali e fihlellehang.
Ho qala ha ts'ebetso ea hypoglycemic ea Biosulin e khuts'oane ho nka metsotso e 30. Tšusumetso e kholo kamora hore ente e bonoe ho mefuta ea lihora tse 2-4, bolelele ba nako ea ts'ebetso ke lihora tse 6-8.
Matšoao a ho sebelisoa
Biosulin H e bonts'oa bakeng sa ts'ebeliso ea lefu la tsoekere la mofuta oa 1. Mofuta oa 2 o fuoa bakuli ka lebaka la ho hana lithethefatsi tse fokotsang tsoekere molomo.
Biosulin H e bonts'oa bakeng sa ts'ebeliso ea lefu la tsoekere la mofuta oa 1.
Le lefu la tsoekere
Tekanyetso ea letsatsi le letsatsi ea lithethefatsi e khethoa ho latela litšobotsi tsa mokuli. Hoa hlokahala ho bala hantle insulin bakeng sa boima ba 'mele. Tekanyetso e tloaelehileng ea lithethefatsi ka letsatsi e tloha ho 0.5 ho isa ho 1 IU, ho latela boima ba 'mele ba motho. Insulin e lokiselitsoeng tsamaiso e lokela ho ba ka mocheso oa kamore. Hangata, e tsamaisoa makhetlo a 3 ka letsatsi, 'me ka linako tse ling e imena habeli. Haeba palo ea letsatsi le letsatsi e feta 0,6 IU / kg, joale u hloka ho etsa liente tse 2 karolong efe kapa efe ea 'mele.
Tekanyetso ea letsatsi le letsatsi ea lithethefatsi e khethoa ho latela litšobotsi tsa mokuli.
Biosulin e kenngoa ka har'a mpa, thipa, mpa, mokokotlo - hohle moo ho nang le mafura a lekaneng a tlasa. Litsi tsa ente e fetotsoe ho thibela nts'etsopele ea ts'ebetso ea lipodystrophy.
Intramuscularly e fanoa feela ka tlasa taolo e haufi ea setsebi. Ka linako tse ling e kopantsoe le insulin e mahareng ea lebitso le le leng. Kenyelletso e joalo e hloka ho lekola khafetsa boemo ba glycemia.
Mokhoa oa ho tsamaisa Biosulin o fapana ho latela mofuta oa moriana o sebelisitsoeng. Ha o sebelisa mofuta o le mong feela oa insulin, tatellano ea liketso e tjena:
- Ho bolaoa ha sebopeho sa lera ka botlolong ka ethanol hoa etsoa.
- Hlahisa moea ka har'a siling ka tekanyo e lekanang le tekanyetso e boletsoeng, ebe u tlatsa botlolo ka moea o lekanang.
- E fetole 180º fatše ebe o letsa lethal dose e neng e baliloe pele ea Biosulin.
- Tlosa nale, tlosa moea sindeng. Etsa bonnete ba hore daele e nepahetse.
- Etsa ente.
Ha u sebelisa mefuta e 'meli ea litlhare, liketso tsa mokuli li tla ba ka tsela e latelang:
- Ho bolaoa ha li-membrane tse fumanehang maboteng hoa etsoa.
- U hloka ho tsamaisa botlolo ka insulin e telele ho fihlela tharollo e na le 'mala o lekanang (o sa tšoeu).
- Fokotsa moea ka hara syringe ho latela tekanyetso ea insulin e mahareng kapa e telele. Ho hlokahala hore nale e kenngoe ka sejelong ka insulin, e ntše moea o tsoang le ho ntša nale. Ka nako ena, "insulin" e mahareng kapa e telele ha e kene syringe.
- Rala moea ka hara seratsoana ka nako eo ka eona insulin e khuts'oane e tla kenang. Kenya moea ka botlolong. E fetole 'me u toroe ka bongata ba meriana e boletsoeng.
- Nka nale, tlosa moea o mongata. Lekola litekanyetso tse nepahetseng.
- Pheta mehato e ts'oanang, ho bokella insulin e mahareng kapa e telele ho tloha vial. Tlosa moea.
- Etsa ente ho tsoa ho motsoako oa insulin.
Kamora ho ente, tlohela nale ka tlasa letlalo metsotso e ka bang 6.
Sesebelisoa se ka hlahisoa ka katse e nang le pene ea syringe e nang le nale, 5 ml. Pente ea syringe e beha 3 ml ea insulin. Pele u e sebelisa, etsa bonnete ba hore ha e na sekoli. Kamora hore mokotla o kenngoe syringe, strip e lokela ho bonahala ka fensetere ea ea e tšoereng.
Kamora ho ente, tlohela nale ka tlasa letlalo metsotso e ka bang 6. Nako ena kaofela konopo e bolokiloe e le maemong a butsoitseng, ka hona ho nepahala ha lethal dose hoa netefatsoa. Kamora nako ena, selepe se ka tlosoa ka hloko. Cartridge ha e reretsoe ho tlatsa, e hlahisoa feela bakeng sa ts'ebeliso ea motho ka mong.
Kamora ho fela ha insulin, e lokela ho lahloa.
Ho tloha ka lehlakoreng la metabolism
E ka baka karabelo ea hypoglycemic. Motho a ka ba le matšoao a latelang:
- pallor ea letlalo le membrane ea mucous,
- ho fufuleloa ho eketsehileng
- palpitations
- ho thothomela hoa mesifa
- maikutlo a bohale a tlala,
- thabo e kholo, ka linako tse ling ho ba mabifi, ho halefa, ho hloka maikutlo le pherekano ea menahano,
- feberu
- bohloko bo boholo sebakeng sa hlooho,
- tlolo ea kutloisiso ea mesifa.
Ho tloha ho ho nka Biosulin, ho ka ba le mofufutso o eketsehileng.
Ho tsoa ho ho nka Biosulin, ho kanna ha ba le maikutlo a ho otla ha pelo khafetsa.
Ho tloha ho ho nka Biosulin ho ka ba le bohloko bo bohale sebakeng sa hlooho.
Hypoglycemia ea nako e telele e sa lebelloang e ka lebisa ho ho lemala ha hypoglycemic:
- pallor le mongobo oa letlalo,
- keketseho ea sekhahla sa pelo,
- mongobo oa leleme
- eketseha ha molumo oa mesifa,
- Ho phefumoloha ho sa tebang le ka potlako.
Ha a akhehile haholo, mokuli ha a tsebe letho. Ha a na likhakanyo, molumo oa mesifa oa fokotseha, mofufutso oa emisa, boemo ba hae ba pelo bo tenehile. Ho hloleha ho phefumoloha. Khatello e kotsi ka ho fetisisa ea komello ea hypoglycemic ke edema ea "cerebral" edema, e lebisang ho ho ts'oaroa hoa moea.
Ka nts'etsopele ea lipontšo tsena, ho bohlokoa ho fa motho tlhokomelo e hlokahalang ea bongaka ka nako. Hang ha e fanoa, ho ka ba bonolo hore motho a be le komello e kotsi ea hypoglycemic. Tsamaiso ea insulin maemong a ho fokotseha tsoekere ea mali e na le litlamorao tse bolaeang lefu la tsoekere.
Hypoglycemia ea nako e telele e sa lebelloang e ka lebisa ho ho fokotseha hoa kelello.
Ka thupelo ea ente ea kalafo ea Biosulin, likarabo tsa allergic lia khoneha: lekhopho la letlalo, edema, e sa tloaelehang haholo - karabelo ea anaphylactoid. Boitšoaro ba lehae sebakeng sa ente bo ka hlaha - ho hlohlona, redness, le ho ruruha hanyane.
Litaelo tse khethehileng
Ho thibetsoe ho sebelisa moriana ha o se o fetohile 'mala kapa ho na le likarolo tse thata ho lona. Nakong ea kalafo, o hloka ho hlahloba hore na glucose e ngata maling. Lintlha tsa ponahalo ea hypoglycemia ke:
- mofuta oa insulin,
- qobelloa ke tlala
- keketseho e matla ea boikoetliso,
- mafu a fokotsang tlhoko ea insulin (mohlala, menoang le meno, ho fokotseha hoa tšebetso ea adrenal, ts'ebetso ea qoqotho e senyehileng kapa gland ea pituitary),
- phetoho ea sebaka sa ente,
- ho sebelisana le meriana e meng.
E 'ngoe ea lisosa tsa ponahalo ea hypoglycemia ke keketseho e matla ea boikoetliso ba' mele.E 'ngoe ea lisosa tsa ponahalo ea hypoglycemia ke ho sebelisana le lithethefatsi tse ling.E 'ngoe ea lisosa tsa ponahalo ea hypoglycemia ke tlala e qobelloang.
Ho phatloha ka ente ea biosulin ho bakuli ba nang le lefu la tsoekere le itšetlehileng ka insulin ho lebisa ho tsoeleng pele ha hyperglycemia. Lipontšo tsa eona:
- molomo o omileng
- khafetsa ho ntša
- ho nyekeloa ke pelo le ho hlatsa,
- redness ea letlalo le mucous membrane,
- takatso e fokotsehileng
- monko oa acetone le liapole tse kolobisitsoeng moeeng o felletseng.
Hyperglycemia ea mofuta ona oa lefu la tsoekere ntle le kalafo e lekaneng e ka lebisa ho ketoacidosis.
Phetoho ea tekanyetso ea Biosulin e etsoa le:
- keketseho ea moroalo,
- mafu a tšoaetsanoang
- Lefu la Addison
- mafu a tšoelesa ea tlhaho
- mathata a sebete
- phetoho ea lijo.
Phetoho ea tekanyetso ea Biosulin e etsoa le mafu a tšoaetsanoang.
Phetoho ea tekanyetso ea Biosulin e etsoa ka phetoho ea lijo.
Phetoho ea tekanyetso ea Biosulin e etsoa ka keketseho ea matla a moroalo.
Ha hoa lumelloa ho enta insulin ea ketso ea nako e telele ho emeng haeba, ka lebaka la ho thothomela, e ea hlohlona ebile e opaque. Hormone e joalo e na le chefo ebile e ka baka chefo e matla. Ts'ebeliso ea lithethefatsi lipompong tsa insulin ha e etsoe.
Bongata ba biosulin
Haeba tekanyetso e fetisitsoe, hypoglycemia e ka hlaha. Ho haella ha tsoekere e bonolo ho felisoa ka ho ja lijo tse tsoekere kapa tse nang le lik'habohaedreite. Batho ba nang le lefu la tsoekere ba hloka ho ba le liswiti kapa lijo tse nang le lik'habohaedreite tse bonolo tse nang le tsona ka linako tsohle.
E hloka tokiso ea lethal dose ho batho ba lilemo tse fetang 65.
Ka komisi, Dextrose e kenngoa mothapong, "glucagon s / c" e kena mothapong kapa mesifa. Hang ha kelello ea mokuli e hlaphoheloa, o hloka ho ja lijo tse nang le tsoekere.
Ho sebelisana le lithethefatsi tse ling
Ho na le meriana e amang tlhokahalo ea lefu la tsoekere la insulin. Phello e theolelang tsoekere ea lithethefatsi e ka ba teng:
- meriana e fokotsang tsoekere e sebelisitsoeng bakeng sa lefu la tsoekere ka hare,
- MAO e thibelang lithethefatsi
- Metsi-a-block
- Li-inhibitors tsa ACE
- sulfonamides,
- li-steroid le li-anabolics,
- carbonic anhydrase inhibitors,
- Bromocriptine
- Pyridoxine
- Octreotide
- Ketoconazole,
- Mebendazole,
- Theophylline
- Tetracycline
- li-agents tse nang le lithium
- litlhare tsohle tse nang le ethyl alcohol.
Phello e fokotsang tsoekere ea lithethefatsi tse bakoang ke bromocriptine.
Phello e fokotsang tsoekere ea lithethefatsi tse bakoang ke Octreotide.
Phello e fokotsang tsoekere ea lithethefatsi tse bakoang ke pyridoxine.
Lithako tse latelang li fokotsa ts'ebetso ea hypoglycemic ea Biosulin:
- litlhare tsa kahare tsa thibelo ea bokhachane
- GKS,
- qoqotho ea qoqotho
- diuretics ea letoto la lihlooho tsa thiazide,
- Heparin
- lingaka tsa khatello ea maikutlo
- audiathomimetic
- Clonidine hydrochloride,
- ho bolela hore thibela mosebetsi oa calcium tubules,
- Morphine
- Phenytoin.
Ho tsuba ho thusa ho fokotsa phello ea hypoglycemic ea Biosulin.
Tekanyo ea joala
E nyenyefatsa ho hanyetsa hoa mmele ho ethanol.
Li-analog tsa mofuta o nkoang oa insulin ke:
- Ha re qhekelle,
- Gensulin
- Isulin insulin
- Insuran
- Protamine insulin
- Protafan
- Rinsulin
- Rosinsulin,
- Humulin
- Humulin-NPX.
Protamine-insulin ke e 'ngoe ea lipapatso tsa Biosulin.
Rinsulin ke e 'ngoe ea lipapatso tsa Biosulin.
Rosinsulin ke e 'ngoe ea lipapatso tsa Biosulin.
Tlhahlobo mabapi le biosulin
Irina, ea lilemo li 40, setsebi sa endocrinologist, Samara: "Bakeng sa khalemelo ea tsoekere ea mali, ke fana ka litlatsetso tse potlakileng le tse mahareng tsa Biosulin bakeng sa bakuli. Moriana ona o mamelloa hantle haeba litekanyetso le nako ea tsamaiso li baloa ka nepo, litlamorao tse sa rateheng ha li fanoe ke bakuli bohle. matsatsi, a bontšang puseletso e ntle ea lefu la tsoekere. "
Svetlana, ea lilemo li 38, setsebi sa endocrinologist, Rostov-on-Don: "Mofuta o sebetsang oa insulin bakeng sa kalafo ea bakuli ba nang le mofuta oa lefu la tsoekere o itšetlehileng ka sena. Ho latela sena, phetolelo e potlakileng ea lithethefatsi e laetsoe, hobane ho bohlokoa ho lefa tefo ea glucose pele o e-ja mofuta oa lefu la tsoekere la 2. E thusa ho laola tsoekere ka botlalo letsatsi lohle. "
Tlhahiso ea Biosulin N Tsela ea ho khetha insulin e nkang nako e telele?
Sergey, ea lilemo li 45, Moscow: "Ke nka Biosulin P e le e 'ngoe ea li-insulin tse sebetsang haufinyane. E etsahala nakong ea halofo ea hora, ke ho re, tsamaiso ea meriana e ka hokahanngoa habonolo le lijo life kapa life. Ke lula ke bala palo ea insulin ka hloko ho latela boima ba ka. le palo ea lijo, ka hona, liketsahalo tsa hypoglycemia lia fumaneha. Ho bile le litlamorao tse ling. "
Irina, ea lilemo li 38, St. Petersburg: "Ke nka Biosulin H e le e 'ngoe ea mefuta e fapaneng ea li-insulin tse sebetsanang le maemo a mang. Ke khetha ho sebelisa lisenthimerara tse khethehileng: e bolokehile ebile e ts'epahala ho feta. Kamehla ke lekanya tekanyo ea lithethefatsi tsa meriana le ho e kenya ho latela litaelo tse kentsoeng. , ho hlaha linako tse ling tsa hypoglycemia. Ke ithutile ho e lemoha le ho e emisa ka nako. "
Litsebi tsa lefu la tsoekere
Igor, ea lilemo li 50, Ivanovo o re: "Ke sebelisa biosulin ea bohareng le e khutsoanyane bakeng sa kalafo ea lefu la tsoekere. Ha ho hlokahala, ke e kenya ente e le 'ngoe. Moriana o nka khato hang hang mme ha o bake tsoekere e matla kapa khatello ea maikutlo pele maemo. Ke ja lijo hammoho le ente ea insulin. Sena sohle se boloka maemo a ka a tsoekere a le tloaelehileng. "
Tekanyetso le tsamaiso
Biosulin P e etselitsoe tsamaiso ea SC, IM le IV. Khokahanyo ea lethal dose le mokhoa oa tsamaiso ea lithethefatsi li ikemiselitsoe ho latela matšoao a khatello ea tsoekere maling le litšoaneleho tsa motho ka mong.
Ho ea ka litaelo, tekanyo e tloaelehileng ea letsatsi le letsatsi e fapana ho tloha ho 0.5 ho ea ho 0.1 IU ka kilogram ea boima ba 'mele oa mokuli.
Tharollo kapa ho emisoa ho khothalletsoa ho fuoa makhetlo a mararo ka letsatsi halofo ea hora pele ho lijo kapa lijo tse bobebe ka ts'ebeliso ea lihlahisoa tse nang le lik'habohaedreite. Maemong moo sena se hlokahalang, khafetsa ea lits'ebetso e eketsoa ho 5 kapa 6. Haeba tekanyetso ea letsatsi le letsatsi e feta 0,6 IU, tharollo e fanoa ke bonyane liente tse peli likarolong tse fapaneng tsa 'mele.
E le molao, Biosulin ka tsela ea tharollo e laetsoe hore e phuthoe ka tlasa letlalo la mpa ea mpa ea mpa. Ho emisoa ho khothalletsoa ho tsamaisoa thipa.
Ho thibela nts'etsopele ea lipodystrophy (mafura a bakoang ke mafura), ho hlokahala hore ho fetoloe sebaka sa ente sebakeng se khothalletsoang sa anatomical. Ho entoa ho lumelloa ho etsoa ka leboteng la mpa, tikoloho ea mesifa e boreleli ea lehetla, serope kapa lesoba.
Pele o sebelisoa, biosulin e lokela ho futhumatsoa ho mocheso oa kamore. Ente e etsoa hantle hantle lejoeng la letlalo, hobane hona ho fokotsa kotsi ea moriana ho kena mosing.
Kaha tharollo Biosulin P ke insulin e nkang nako e khuts'oane, e sebelisoa hangata hammoho le boitokisetso ba ho sebetsa bohareng (ho emisa Biosulin H kapa 30/70).
Ho / m le ho / ho kenyelletsa ha moriana ka mokhoa oa tharollo ea ente ho lumelloa feela ka tlasa tlhokomelo ea ngaka.
Haeba ho hlokahala, tlhokomelo e matla Biosulin N e ka sebelisoa hanngoe kapa habeli ka letsatsi e le insulin. Joaloka molao, e tsamaisoa e le moemeli oa monotherapeutic hoseng le mantsiboea, pele ho lijo tsa motšehare ho khothalletsoa ho kenya ente ho emisoa hammoho le insulin.
Litlamorao
Ka ho susumetsa metabolism ea lik'habohaedreite 'meleng, Biosulin e ka baka nts'etsopele ea maemo a hypoglycemic, a bonahatsoang ke letlalo le boreleli, ho eketsa mofufutso, ho thothomela, tlala, ho hlaka, hlooho e bohloko, paresthesia (ho tšoha, ho akheha le ho akheha) molomong.
Haeba ho na le hypoglycemia e matla, mokuli a ka oela ka har'a komello ea hypoglycemic.
Litla-morao tse ling tsa Biosulin e bontšitsoeng litaelong ke lintho tse amang (li-rashes tsa letlalo, edema ea Quincke, hangata ho ts'oaroa ha anaphylactic) le tsa lehae (hyperemia, ho hlohlona, ho hlonama sebakeng sa ente). Tšebeliso ea lithethefatsi nako e telele e ka baka nts'etsopele ea lipodystrophy.
Ho boetse ho na le bopaki ba ponahalo ea liphoso tsa edema le tsa nakoana, tse atisang ho hlokomeleha mehatong ea pele ea kalafo le Biosulin.
Lipehelo le maemo a polokelo
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