Emoxibel - litaelo tsa semmuso bakeng sa tšebeliso

Mekhoa ea ho nooa ea Emoxibel:

• Tharollo ea infusion: e se nang 'mala, e pepeneneng (ka libotlolong tsa khalase ea 100 ml, ka lebokoseng la karete ea 1.
• Tharollo bakeng sa tsamaiso ea methapo (i / v) le methapo ea methapo (i / m): e mebala hanyane kapa e se nang 'mala, e pepeneneng (liphoofolong tse 10 ml, ka li-ampoule tse 5 ml, ka marang-rang a marang-rang a 5 ampoules, ka lebokoseng la 1 kapa 2 sephutheloana kapa botlolo e le 'ngoe),
• Maqhubu a mahlo: ka lesela le mosehla kapa le se nang 'mala, le pepeneneng (ka libotlolong tsa 5 ml, ka lebokoseng la mekotla e 1),
• ente: e se nang 'mala, e pepeneneng (ho li-ampoules tsa 1 ml, ka har'a mekotla e 5 ea li-ampoule tse 5, ka pakete ea li-ampoules tse 10 kapa lipakete tse 1 kapa tse 2 tse nang le sekhahla se fumanehang ka kiteng).

Karolo ea 1 ml Emoxibel Solution Tharollo:

• ntho e sebetsang: methylethylpyridinol hydrochloride (emoxypine) - 0,005 g,
• likarolo tse thusang: metsi a ente, sodium chloride.

Sebopeho sa 1 ml ea tharollo bakeng sa iv le tsamaiso ea methapo ea methapo:

• ntho e sebetsang: methylethylpyridinol hydrochloride (emoxypine) - 0,03 g,
• likarolo tse thusang: metsi a ho entoa, sodium hydrogen phosphate dodecahydrate, sodium sulfite.

Sebopeho sa marotholi a 1 ml a Ophthalmic Emoxibel:

• ntho e sebetsang: methylethylpyridinol hydrochloride (emoxypine) - 0,01 g,
• likarolo tse thusang: metsi a ente - ho fihla ho 1 ml, sodium hydrogen phosphate dodecahydrate - 0,007 5 g, phofo ea potasiamo dihydrogen - 0,006 2 g, sodium benzoate - 0,002 g, sodium sulfite - 0,003 g.

Sebopeho sa 1 ml Emoxibel ente:

• ntho e sebetsang: methylethylpyridinol hydrochloride (emoxypine) - 0,01 g,
• likarolo tse thusang: metsi a ente - ho fihla ho 1 ml, tharollo ea hydrochloric acid (0,1 M) - 0,02 ml.

Mofumahali

Ka lebaka la ntho e sebetsang eo e leng karolo ea Emoxibel, e etsa liketso tse latelang:

• e ama ka nepo mokhoa oa ho kopanya mali: e lelefatsa nako ea ho kopana ha mali, e fokotsa lenane la coagulation ka botlalo,
• e eketsa khatello ea lisele tse khubelu tsa mali ho hemolysis le mochine o sithabetsang, o tiisa litho tsa methapo ea methapo ea mali le lisele tse khubelu tsa mali,
• e ntlafatsa maselinyana,
• e eketsa ts'ebetso ea li-enzyme tsa antioxidant, e thibelang hantle oxidation ea lipids ea biomembranes,
• e na le litlamorao tsa li-antitoxic le angioprotective, e tsitsisa cytochrome P₄₅₀,
• e ntlafatsa mekhoa ea bioenergy maemong a feteletseng, e tsamaisana le hypoxia le lipid peroxidation e eketsehileng,
• e eketsa khatello ea kelello ho ischemia le hypoxia,
• le mathata a ischemic le hemorrhagic a ho potoloha ha litho tsa 'mele ho ntlafatsa mesebetsi ea mnemonic, e thusa ho khutlisetsoa ha karolo ea tšebetso ea bokong, e thusa ho lokisa ho se sebetse hantle ha kelello,
• e fokotsa mokokotlo oa triglyceride, e na le thepa e theolelang lipid,
• e fokotsa tšenyo e bakiloeng ke ischemic myocardium, e hlapolle likepe tsa coronary,
• ka infraction ea myocardial, e kenya letsoho ho tloaelehileng tsa metabolism ea myocardial, e potlakisa ts'ebetso ea ho pheta-pheta, e fokotsa boholo ba sepheo sa necrosis,
• ka ho fokotsa menyetla ea ho hloleha ho hlobaela ha pelo ho ama hantle tsela ea tleliniki ea myocardial infarction,
• ka ho se sebetse hantle ho potoloha ho fana ka molao oa tsamaiso ea redox.

Mofumahali

Litšobotsi tsa methylethylpyridinol hydrochloride (emoxypine):

• ho amoheloa: with the / ho qala ho na le nako e tlase ea ho felisoa (T_½ ke metsotso e 18, e bonts'a sekhahla se phahameng sa ho tlosoa maling), boleng ba ho felisoa khafetsa ke 0,041 min, botlalo ba Cl ke 214.8 ml ka motsotso o le mong.
• phetisetso: bophahamo bo bonahalang ba karolelano - 5.2 l, e kenella ka potlako litho le lisele tsa 'mele oa motho, moo e kenngoeng le ho tšeloa matla ka mor'a moo,
• metabolism: e na le li-metabolites tse 5 tse emeloang ke lihlahisoa tse kopantsoeng le tse senyehileng tsa phetoho ea eona, li-metabolites li hlahisoa ke liphio, 2-ethyl-6-methyl-3-hydroxypyridine phosphate e fumaneha ka bongata bo boholo sebeteng,
• excretion: Maemo a pathological a fokotsa sekhahla sa tlhahiso ea sona, e eketsang bioavailability ea eona, hape e eketsa nako ea eona ea bolulo maling (e kanna ea amahanngoa le ho khutla ha hae ho tsoa depong, ho kenyelletsoa ho tsoa ho ischemic myocardium).

Li-pharmacokinetics tsa Emoxibel maemong a methapo ea methapo (mohlala, ka corlary occlusion).

Tharollo ea infusion, tharollo bakeng sa tsamaiso ea iv le / m

• Nako ea ts'ebetso ho bakuli ba nang le likotsi tsa ts'ebetso ea ts'ebetso ea ts'ebetso ea mokokotlo, e sebetsanang le ho holofala kelellong, lefu la sethoathoa le lefu la sethoathoa ho kopantsoe le likotsi tsa bokong, hlooho e lemalang le likotsi tsa boko, ho hloka ts'ebetso ea methapo ea pelo, bokuli ba nakoana bo amanang le lefu la mokokotlo, lefu la hemorrhagic, stroke ka letamong la methapo e kahare ea carotid le tsamaisong ea methapo ea kutlo (sebelisa ts'ebetsong ea methapo ea kutlo le neurology),
• angina pectoris e sa tsitsang, thibelo ea reperfusion syndrome, infarction ea acute myocardial infarction (sebelisa cardiology).

Tharollo ea entetso

• ho chesa, likotsi, maloetse a mpefatsang a komello ea mali,
• ho sithabela ha leihlo la sefahleho le nang le glaucoma nakong ea ts'ebetso,
• mofuta o omileng oa angiosselotic macular degeneration,
• myopathy e thata
• chorioretinal dystrophy (e bohareng le e sephara),
• angioretinopathy, ho kenyeletsa lefu la tsoekere,
• Li-hemorrhage tsa "intraocular" le "subconjunctival" tse tsoang litsong tse fapaneng.
• thrombosis ea mothapo o moholo oa mokokotlo oa retina le makala a eona,
• thibelo le kalafo ea maqeba a mahlo ka khanya e matla (mahlaseli a laser nakong ea mahlaseli a laser, mahlaseli a letsatsi).

Contraindication

• ka tlase ho lilemo tse 18
• boimana (ntle le ente)
• ho nyekeloa (ntle le ente)
• ho se mamellane ha motho ka mong likarolo tsa moriana.

Setsoalle (maloetse / maemo a teng ao ho ona Tsamaiso ea Emoxibel e hlokang tlhokomeliso):

• Tharollo bakeng sa tsamaiso ea methapo le methapo: ho ba teng ha matšoao a ho tsoa mali haholo, ts'ebetso ea bongaka e thibelang hemostasis,
• ente: ho ima, ho nyeka.

Tharollo bakeng sa tsamaiso ea methapo le methapo

Emoxibel e tsamaisoa ka / ho kapa / m. Pele ho tsamaiso ea iv, tharollo e kenngoa ka 200 ml ea tharollo ea 5% ea dextrose kapa 0,9% sodium chloride.

Litekanyetso tsa lithethefatsi le nako ea phekolo li behiloe ka bonngoe.

• methapo ea kutlo, neurosurgery: mokelikeli o kenang oa 0,01 g ka boima ba 1 kg ea boima ba 'mele ka letsatsi ka tekanyo ea marotholi a 20-30 ho 1 min bakeng sa matsatsi a 10-12, ebe mokuli o fetisetsoa ente ea methapo ea methapo ea 0.06-0 , Makhetlo a 3 g makhetlo a 2-3 ka letsatsi matsatsi a 20,
• cardiology: iv drip 0,6-0.9 g makhetlo a 1-3 ka letsatsi ka tekanyo ea marotholi a 20-40 ka 1 min bakeng sa matsatsi a 5-15 ka phetisetso e eketsehileng ea mokuli ho ea / m tsamaiso ea 0.06-0 , 3 g ea moriana makhetlo a 2-3 ka letsatsi matsatsi a 10-30.

Litaelo tse khethehileng

Phekolo ea Emoxibel e etsoa ka tlasa taolo e sa feleng ea mali le khatello ea mali.

Tharollo ea infusion ha ea lokela ho kopanngoa le lithethefatsi tse ling.

Pele ho kenyelletsa marotholi a mahlo, lilense tse bonolo tsa puisano li lokela ho tlosoa. Kamora metsotso e 20 (eseng pejana), lilense li ka apesoa hape. Maemong a phekolo e kopaneng le marotholi a mang a mahlo, Emoxibel e kenyellelitsoe ho qetela, metsotso e 15 (eseng pejana) kamora ho tlosoa ka botlalo ha moriana o fetileng.

Tšusumetso ho bokhoni ba ho khanna makoloi le mekhoa e rarahaneng

Qalong ea ts'ebeliso ea tharollo ea infusion, hammoho le bakuli ba hlokometseng ho otsela kapa ho fokotseha ha khatello ea mali ka mor'a ho sebelisa tharollo bakeng sa tsamaiso ea iv le / m kapa ente, o lokela ho hana ho khanna makoloi le ho etsa mesebetsi e ka bang kotsi.

Sebopeho le mofuta oa tokollo

Tharollo ea Emoxibel bakeng sa tsamaiso ea methapo le methapo - mokelikeli ha o na 'mala kapa o mebala hanyane ho li-ampoules tse 5 ml, o na le:

• Lintho tse sebetsang: emoxypine (methylethylpyridinol hydrochloride) - 30 g,
• Lintho tse ling hape: sodium hydrogen phosphate dodecahydrate, sodium sulfite, metsi.

Lipakete tsa sele 1 kapa 2 likhomphutha. Li-ampoules tse 5 ka lebokoseng la karete. Thupelo, bofokoli.

Foromo ea boholo:

Tlhaloso:
e hlakileng, e se nang 'mala kapa e nang le mebala e nyane.

Sebopeho
Litara e le 1: ntho e sebetsang: methylethylpyridinol hydrochloride (emoxypine) - 30 g,
Baeti: sodium sulfite, sodium hydrogen phosphate dodecahydrate, metsi a ente.

Sehlopha sa Pharmacotherapeutic:

Khoutu: C05CX

Ketso ea pharmacological.
Ke inhibitor ea mekhoa ea mahala ea liphetoho, antihypoxant le antioxidant. Fokotsa viscosity ea mali le pokello ea liplatelete, e eketsa se ka hare ho cyclic nucleotides (cAMP le cGMP) liphatlalatsong tsa methapo ea mali le mokokotlo, e na le ts'ebetso ea fibrinolytic, e fokotsa ho senyeha ha lebota la vascular le kotsi ea hemorrhage, e phahamisa ho ts'oaroa ha tsona hape. E eketsa likepe tsa coronary, nakong e mpe ea infraction ea myocardial e fokotsa boholo ba sepheo sa necrosis, e ntlafatsa boikemisetso ba pelo le mosebetsi oa tsamaiso ea eona. Ka khatello e phahameng ea mali (BP) e na le phello e matlafatsang. A a hlobaetsang le ischemic mathata a ho potoloha ha mali a matsoele a fokotsa botebo ba matsoao a matsoafo, eketsa mesifa ho hanyetsa hypoxia le ischemia.

Mofumahali
Ha o fanoa kahare ho methapo ea 10 mg / kg, halofo ea bophelo ke lihora tse 0,3, netefatso e felletseng ea CL ke 0,2 l / min, moqolo o hlakileng oa kabo ke 5.2 l. Setlhare sena se kenella ka hare ho litho le lisele, moo se behoang le ho kenngoa ts'ebetsong. Ho fumanoe li-metabolites tse hlano tsa methylethylpyridinol, tse emeloang ke lihlahisoa tsa desalkylated le tse kopantsoeng tsa phetoho ea tsona. Methyl ethyl pyridinol metabolites e hlahisoa ke liphio. Palo ea bohlokoa ea 2-ethyl-6-methyl-3-hydroxypyridine-phosphate e fumanoa ka har'a sebete. Ka lefu la pelo le coronary, bioavailability ea eketseha.

Matšoao a ho sebelisoa.
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