Kefsepim - litaelo tsa semmuso bakeng sa tšebeliso

Matšoao a ts'ebeliso ea lithethefatsi Kefsepim ke:
- pneumonia (e leka-lekaneng ebile e le matla) e bakoang ke Streptococcus pneumoniae (ho kenyeletsoa linyeoe tsa ho tloaelana le bacteremia e buellang), Pseudomonas aeruginosa, Klebsiella pneumoniae kapa Enterobacter spp,
- ts'oaetso ea pampitšana ea urine (e rarahaneng le e se nang mathata),
- mafu a tšoaetsanoang ke letlalo le lisele tse bonolo,
- ts'oaetso e rarahaneng ea qoqotho ea ka mpeng (hammoho le metronidazole) e bakoang ke Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter spp.
- Lits'oaetso tsa ts'oaetso tse qapileng khahlanong le semelo sa ts'ireletso ea mmele (mohlala, febrile neutropenia)
- thibelo ea tšoaetso nakong ea ts'ebetso ea ka mpeng,

Litlamorao

Ho tsoa ts'ebetsong ea tšilo ea lijo: lets'ollo, ho nyekeloa, ho hlatsa, ho sokela, bohloko ba ka mpeng, dyspepsia,
Ts'ebetso ea pelo: bohloko bo ka morao ho sternum, tachycardia,
Boitlhaselo ba ho kula: ho hlohlona, ​​lekhopho la letlalo, anaphylaxis, feberu,
Tsamaiso ea methapo e bohareng: ho opeloa ke hlooho, ho akheha, ho hloka boroko, paresthesia, matšoenyeho, pherekano, maloetse,
Sistimi ea khahlapetso: khohlela, 'metso, ho hema,
Boitšoaro ba lehae: ka tsamaiso ea methapo - phlebitis, tsamaiso ea methapo - hyperemia le bohloko sebakeng sa ente,
Tse ling: asthenia, mofufutso, vaginitis, edema ea morao, bohloko ba morao, leukopenia, neutropenia, keketseho ea nako ea prothrombin,

Boimana

Ts'ebeliso ea lithethefatsi Kefsepim nakong ea kemolo ho ka etsahala feela maemong a ha melemo e boletsoeng ho mme e feta kotsi e ka bang teng ho lesea.
Haeba ho hlokahala, ts'ebeliso ea moriana nakong ea lebone e lokela ho etsa qeto ea ho khaotsa ho anyesa.

Ho sebelisana le lithethefatsi tse ling

Ho sebelisa tekanyetso e phahameng ea aminoglycosides ka nako e le ngoe le lithethefatsi KefsepimTlhokomelo e lokela ho nkuoa ho lekola ts'ebetso ea renal ka lebaka la bokhoni ba nephrotoxicity le ototoxicity ea aminoglycoside lithibela-mafu. Nephrotoxicity e ile ea bonoa kamora ts'ebeliso e le 'ngoe ea li-cephalosporin tse ling ka diuretics, joalo ka furosemide. Lithethefatsi tse seng khahlanong le ho ruruha, tse fokotsang ho felisoa ha cephalosporins, li eketsa monyetla oa ho tsoa mali. Khatello ea kefsepim ho tloha ho 1 ho isa ho 40 mg / ml. e lumellana le litharollo tse joalo tsa botsoali: Tharollo ea sodium chloride ea sodium, 0% le 10% tsoekere ea tharollo, tharollo ea 6M sodium lactate ea ente, glucose ea 5% le tharollo ea 0.9% ea sodium chloride ea ente, tharollo ea Ringer ka lactate le 5% dextrose tharollo ea ente. Ho qoba ho sebelisana ha lithethefatsi le lithethefatsi tse ling, tharollo ea Kefsepim (joalo ka lithibela-mafu tse ling tsa beta-lactam) ha ea lokela ho fanoa ka nako e tšoanang ka tharollo ea metronidazole, vancomycin, boreamicin, tobramycin sulfate le netilmicin sulfate. Tabeng ea ho khethoa ha sethethefatsi Kefsepim ka lithethefatsi tsena, o lokela ho kenya lithibela-mafu ka seng ka thoko.

Foromo ea boholo:

phofo bakeng sa tharollo bakeng sa tsamaiso ea methapo le methapo

ka botlolong e le 'ngoe o na le:

Sehlooho

Moetso, g

0.5 g

1 g

Cefepime hydrochloride monohydrate, e baloang ka cefepime

(ho fihlela ho pH ho tloha 4.0 ho isa ho 6.0)

phofo ho tloha tšoeu ho soeuufala tšoeu.

Ketso ea pharmacological

Mofumahali

Cefepime ke lithibela-mafu tse atileng haholo tsa cephalosporin. Cepepime inhibuse syntheine ea protheine ea lisele tsa "bacteric cell wall", e na le pono e fapaneng ea ts'oaetso ea bactericidal khahlanong le libaktheria tse ntle tsa gram le gram-negative, ho kenyelletsa le mefuta e mengata e hanyetsanang le aminoglycosides kapa karolo ea boraro ea lithibela-mafu tsa cephalosporin tse kang ceftazidime.

Cepepime e loants'oa haholo ke hydrolysis ea li-beta-lactamase tse ngata, e na le tumellano e tlase ea li-beta-lactamase mme e kenella ka potlako liseleng tsa libaktheria tse seng hantle tsa gram.

Ho netefalitsoe hore cefepime e na le tumellano e phahameng haholo ea mofuta oa "penicillin binding protein" (PSB), tšebelisano e phahameng bakeng sa mofuta oa 2 PSB, le tumellano e itekanetseng ea mofuta oa 1a le 16 PSB.

Cepepime e sebetsa khahlano le likokoana-hloko tse latelang:

Staphylococcus aureus (ho kenyelletsa le mefuta e hlahisang beta-lactamase), Staphylococcus epermidis (ho kenyelletsa le mefuta e hlahisang beta-lactamase), mefuta e meng ea Staphylococcus spp. C), Streptococcus pneumonia (ho kenyelletsa le mathata a hanyetsanang le penicillin - khatello e fokolang ea inhibitory e tloha ho 0,1 ho isa ho 1 μg / ml), beta-hemolytic Streptococcus spp. (lihlopha C, G, F), Streptococcus bovis (sehlopha D), Streptococcus spp. lihlopha tsa bosoasoi,

Tlhokomeliso: Boholo ba mefuta ea enterococcal, e kang Enterococcus faecalis, le staphylococci e thibelang methicillin e hanyetsana le lithibela-mafu tse ngata tsa cephalosporin, ho kenyeletsoa le nako ea khefu.

Acinetobacter calcoaceticus (sub-likarolo tsa anitratus, lwofii),
Aeromonas hydrophila,
Capnocytophaga spp.,
Tsena ea spopr. (ho kenyeletsoa le di-Citrobacter diversus, Citrobacter freundii),
Campylobacter jejuni,
Enterobacter spp. (ho kenyeletsoa Enterobacter cloacae, Enterobacter aerogene, Enterobacter sakazakii),
Escherichia coli,
Gardnerella vaginalis,
Haemophilus ducreyi,
Haemophilus influenzae (ho kenyeletsoa le beta-lactamase e hlahisang mefuta e meng),
Haemophilus parainfluenzae, Hafnia alvei,
Klebsiella spp. (ho kenyeletsoa Klebsiella pneumoniae, Klebsiella oxytoca, Klebsiellaaleenae),
Legionella spp.,
Morganella morganii,
Moraxella catarrhalis (Branhamella catarrhalis) (ho kenyelletsa le lintho tse hlahisang beta-lactamase),
Neisseria gonorrhoeae (ho kenyeletsoa likarolo tse hlahisang beta-lactamase),
Neisseria meningitidis,
Pantoea agglomerans (eo pele e neng e tsejoa e le li-agglomerans tsa Enterobacter),
Proteus spp (ho kenyeletsoa Proteus mirabilis le Proteus vulgaris),
Providencia spp. (ho kenyelletsa Providencia rettgeri, Providencia stuartii),
Pseudomonas spp. (ho kenyeletsoa Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas stutzer),
Salmonella spp.,
Serratia spp. (ho kenyeletsoa Serratia marcescens, Serratia liquefaciens),
Shigella spp.,
Tshepiso ea Tsena,

Hlokomela: Cefepime ha e sebetse khahlanong le mefuta e mengata ea Stenotrophomonas maltophilia, eo pele e neng e tsejoa e le Xanthomonas maltophilia le Pseudomonas maltophilia).

Anaerobes:

Libaktheria spp.,
Clostridium perfringens,
Fusobacterium spp.,
Mobiluncus spp.,
Peptostreptococcus spp.,
Prevotella melaninogenica (e tsejoang ka Bacteroides melaninogenicus),
Veillonella spp.,

Hlokomela: Cepepime ha e sebetse khahlano le Bacteroides fragilis le Clostridium Hardile. Khanyetso ea bobeli ea likokoana-hloko ho tloha nakong ea khale e ntse e hola butle.

Mofumahali

Karolelano ea plasma e tloaelehileng ea batho ba baholo ba phetseng hantle ka linako tse fapaneng ka mor'a ts'ebetso e le 'ngoe ea metsotso e 30 ho isa ho lihora tse 12 le ho tsepamisa mohopolo ho tebileng (C_tlhokomeliso) li fanoe ka har'a tafole e ka tlase.

Karolelano ea likhakanyo tsa "plasma cefepime" (μg / ml) kamora tsamaiso ea methapo.