Melfor (Melfor)

Ka lebaka la monyetla oa ho theha phello e khahlisang, tsamaiso ea capsule e khothalletsoa. Melemo Hoseng. Tekanyetso e beoa ka bonngoe ho latela matšoao le tsela ea tsamaiso.
Ha ho nooa ka molomo, lethal dose le le leng ke 0,25-1 g, maqhubu a tsamaiso le nako ea kalafo e its'etleha ho lipontšo.
Ka tsamaiso ea iv, lethal dose ke 0.5-1 g 1 nako / letsatsi, nako ea kalafo e ipapisitse le lipontšo.
0.5 ml ea tharollo ea ente ka bongata ba 500 mg / 5 ml e tsamaisoa ka mokhoa o hlakileng matsatsi a 10.

Contraindication

Contraindication mabapi le ts'ebeliso ea lithethefatsi Melemo ke: khatello e matla ea intracranial (ho kenyelletsa le maemong a ho senyeha ha venous outflow, intracranial tumors), boimana, ho lactation (matsoele), bana le bacha ba ka tlase ho lilemo tse 18, kutloisiso e matla ea meldonium.

Ho sebelisana le lithethefatsi tse ling

Ha e kopantsoe, meldonium e ntlafatsa ts'ebetso ea lithethefatsi tsa antianginal, lithethefatsi tse ling tsa antihypertensive, glycosides ea pelo.
Ka ts'ebeliso e ts'oanang ea meldonium e nang le nitroglycerin, nifedipine, alpha-blockers, li-antihypertgency agents le li-vasodilators tsa peripheral, tachycardia e leka-lekaneng, hypotension ea arterial e ka hlaha (ka mekhoa ena, ho hlokahala tlhokomeliso).

Matšoao a ho sebelisoa

- Ts'ebetso e fokotsehileng, ts'ebetso e eketsehileng ea 'mele, nako ea ts'ebetso ho potlakisa ntlafatso.

- E le karolo ea kalafo e rarahaneng ea lefu la pelo le ho ferekana, pelo e sa foleng, Cardialgia khahlano le semelo sa methapo ea methapo ea methapo ea methapo.

- E le karolo ea kalafo e rarahaneng bakeng sa likotsi tsa cerebrovascular (likotsi tsa "cerebrovascular" tsa mofuta oa ischemic, haholo-holo karolo e mpe haholo, ho se lekane ka sekhahla ha mmele).

- Pheko e rarahaneng ea lefu la ho itlopa joala.

- Ho potoloha ha methapo ea methapo ea mali, hemophthalmus le hemorrhages ea methapo ea methapo e fapaneng ea methapo ea methapo ea methapo ea methapo le makala a eona, retinopathy ea etiology tse fapaneng (ho kenyeletsa lefu la tsoekere le khatello ea mali).

Mokhoa oa ho sebelisa: litekanyetso le kalafo

Tharollo ea entetso

Keketseho ea khatello ea kelello le 'mele: kahare ho 500 mg (5 ml) hang ka letsatsi. Tsela ea kalafo ke matsatsi a 10-14. Haeba ho hlokahala, thupelo e phetoa kamora libeke tse 2-3. Bakeng sa mafu a pelo (e le karolo ea kalafo e rarahaneng): kahare ho 500-1000 mg (5-10 ml). Tsela ea kalafo ke matsatsi a 10-14.

Ketsahalo ea Ischemic ea cerebrovascular, haholo-holo mokokotlo (e le karolo ea kalafo e kopaneng): 500 mg ka ho lekana (5 ml) nako e le 1 ka letsatsi bakeng sa matsatsi a 7- 7, ebe a nkuoa ka molomo.

Ho haelloa ke "cerebrovascular" ka ho sa feleng: 500 mg intramuscularly (5 ml) hang ka letsatsi. Nako ea kalafo ke matsatsi a 10-14, ebe ba fetoha ho tsamaiso ea molomo. Lefu la ho itlopa joala: ka methapo - 500 mg (5 ml) makhetlo a 2 ka letsatsi. Nako ea kalafo ke matsatsi a 7-10.

Vascular pathology ea fundus le retinal dystrophy: tharollo ea ente ea 50 mg (0.5 ml) e fanoa ka mokhoa o khutšoane hape ka mokhoa o sa sebetseng matsatsi a 10.

E nooa ka molomo, pele ho lijo, ka lebaka la phello e thabisang ea ho e sebelisa hoseng.

Ho eketsa ho ikoetlisa ka makhetlo a 250 mg makhetlo a 4 ka letsatsi. Tsela ea kalafo ke matsatsi a 10-14. Haeba ho hlokahala, kalafo e phetoa kamora libeke tse 2-3. Baatlelete ba laetsoa 500-1000 mg makhetlo a 2 ka letsatsi pele ho koetliso. Nako ea thupelo nakong ea litokisetso ke matsatsi a 14-21, nakong ea tlholisano - matsatsi a 10-14.

Le maloetse a pelo (e le karolo ea kalafo e rarahaneng):

E tsitsitseng ea angina pectoris - makhetlo a 250 mg makhetlo a 3 ka letsatsi bakeng sa matsatsi a 3-4, ebe 250 mg makhetlo a 3 ka letsatsi makhetlo a 2 ka beke bakeng sa likhoeli tse 1-1,5.

Myocardial infarction: ka nako e hlabang - ka methati, ebe kahare ka 500 mg ka letsatsi, o sebelisa tekanyetso eohle hang kapa habeli ka letsatsi.

Ho hloleha ha pelo ho sa foleng - 500-1000 mg hang ka letsatsi. Nako ea kalafo ke libeke tse 4-6.

Cardialgia bokong ba dishormonal myocardial dystrophy 250 mg makhetlo a 2 ka letsatsi. Nako ea kalafo ke matsatsi a 12.

Kotsi ea Cerebrovascular: ka nako ea ashe, ka methapo, ebe 500 mg ka letsatsi, ka ho khetheha halofo ea pele ea letsatsi. Nako ea kalafo ke libeke tse 4-6.

Ho tlohela joala syndrome (e le karolo ea phekolo e ikhethileng) 500 mg makhetlo a 4 ka letsatsi. Nako ea kalafo ke matsatsi a 7-10.

Ketso ea pharmacological

Motsoako o sebetsang oa Melfora ke meldonium - analog ea moetso oa gamma-butyrobetaine, e hatellang ketso ea gamma-butyrobetaine hydroxynase. Maemong a ischemia, e khutlisa botsitso ba lits'ebetso tsa ho tsamaisoa ha oksijene le tšebeliso ea eona liseleng. Mochine oa ts'ebetso o khetholla phapang ea litlamorao tsa eona ea pharmacological: ts'ebetso e eketsehileng, matšoao a fokotsehileng a khatello ea kelello le 'mele, ts'ebetso ea ts'ebetso ea litho tsa mesifa le ho se sireletsehe ha mmele.

E na le phello ea pelo: haeba ho na le tšenyo e mpe ea ischemic myocardium, e liehisa ho etsoa ha necrotic zone, e khutsufatsa nako ea ntlafatso. Ka ho nyekeloa ke pelo, e eketsa ts'ebetso ea myocardial, e eketsa mamello, hape e fokotsa leqhubu la litlhaselo tsa angina. A a hlobaetsang le a sa foleng a ischemic mathata a ho potoloha ha litho tsa mali a mali ho ntlafatsa phallo ea mali ka leihlo la ischemia, le kenya letsoho ho abolleloeng ha mali molemong oa sebaka sa ischemic. E sebetsa hantle maemong a methapo le methapo ea methapo ea methapo ea methapo. E na le tšusumetso ea tonic tsamaisong ea methapo e bohareng ebile e tlosa litšitiso tse sebetsang tsa tsamaiso ea methapo ea motho ea maikutlong le ea boithaopo ho bakuli ba nang le joala bo sa foleng ba nang le lefu la ho ikhula.

Litlamorao

Litla-morao tsa (ho fokotseha: bofubelu, lekhopho la letlalo, ho hlohlona, ​​ho ruruha), dyspepsia, tachycardia, ho fokotseha kapa ho eketseha ha khatello ea mali, ho ruruha ha ho khonehe.

Ka moriana o feteletseng oa Melfort, ho fokotseha ha khatello ea mali, hlooho ea hlooho, tachycardia, ho tsekela, ho fokotseha ka kakaretso. Phekolo ke letšoao.

Fomu ea ho lokolla, ho paka le ho hlophisoa

Li-pcs tse 5. - Liphutheloana tsa lithutsoana (1) - lipakete tsa karete.
Li-pcs tse 5. - liphutheloana tsa lithutsoana (2) - lipakete tsa karete.
Li-pcs tse 5. - Liphutheloana tsa lithutsoana (3) - lipakete tsa karete.
Li-pcs tse 5. - Liphutheloana tsa lithutsoana (4) - lipakete tsa karete.
Li-pcs tse 5. - liphutheloana tsa lithutsoana (6) - lipakete tsa karete.
Li-pcs tse 5. - Marang-rang a lithutsoana (10) - lipakete tsa karete.
Li-pcs tse 10. - Liphutheloana tsa lithutsoana (1) - lipakete tsa karete.
Li-pcs tse 10. - liphutheloana tsa lithutsoana (2) - lipakete tsa karete.
Li-pcs tse 10. - Liphutheloana tsa lithutsoana (3) - lipakete tsa karete.
Li-pcs tse 10. - Liphutheloana tsa lithutsoana (4) - lipakete tsa karete.
Li-pcs tse 10. - liphutheloana tsa lithutsoana (6) - lipakete tsa karete.
Li-pcs tse 10. - Marang-rang a lithutsoana (10) - lipakete tsa karete.
Li-pcs tse 30 - Liphutheloana tsa lithutsoana (1) - lipakete tsa karete.
Li-pcs tse 30 - liphutheloana tsa lithutsoana (2) - lipakete tsa karete.
Li-pcs tse 30 - Liphutheloana tsa lithutsoana (3) - lipakete tsa karete.
Li-pcs tse 30 - Liphutheloana tsa lithutsoana (4) - lipakete tsa karete.
Li-pcs tse 30 - liphutheloana tsa lithutsoana (6) - lipakete tsa karete.
Li-pcs tse 30 - Marang-rang a lithutsoana (10) - lipakete tsa karete.
Li-pcs tse 10. - Lijana tsa polymer (1) - liphutheloana tsa karete.
20 likhomphutha. - Lijana tsa polymer (1) - liphutheloana tsa karete.
Li-pcs tse 30 - Lijana tsa polymer (1) - liphutheloana tsa karete.
Li-pcs tse 40. - Lijana tsa polymer (1) - liphutheloana tsa karete.
Li-pcs tse 50. - Lijana tsa polymer (1) - liphutheloana tsa karete.
Li-pcs tse 100 - Lijana tsa polymer (1) - liphutheloana tsa karete.

Matšoao a lithethefatsi

Bakeng sa tsamaiso ea molomo kapa ea methapo: joalo ka karolo ea kalafo e rarahaneng ea lefu la pelo (angina pectoris, infraction ea myocardial), ho nyekeloa ke pelo le methapo, le methapo ea methapo ea methapo, e le karolo ea kalafo e rarahaneng ea ho hloka taolo ea methapo ea pelo le methapo ea methapo, ho fokotseha ha ts'ebetso, ho fokola hoa mmele (ho kenyeletsoa ho baatlelete), nako ea ts'ebetso ea ho potlakisa ntlafatso, lefu la ho khaotsa ho lemalla joala bo sa foleng (hammoho le kalafo e khethehileng, joala ZMA).

Bakeng sa tsamaiso ea parabulbar: pherekano e potileng ea potoloho ea methapo methapong ea methapo ea methapo le methapo ea methapo ea methapo ea kutlo tse fapa-fapaneng, thrombosis ea methapo e kholo ea methapo le makala a eona, retinopathy ea etiology tse fapaneng (ho kenyeletsoa lefu la tsoekere le hypertonic) - feela bakeng sa tsamaiso ea parabulbar.

Melemo ea litekanyetso

Mabapi le monyetla oa ho theha phello e khahlisang, ho khothalletsoa ho e sebelisa hoseng. Tekanyetso e beoa ka bonngoe ho latela matšoao le tsela ea tsamaiso.

Ha ho nooa ka molomo, lethal dose le le leng ke 0,25-1 g, maqhubu a tsamaiso le nako ea kalafo e its'etleha ho lipontšo.

Ka tsamaiso ea iv, lethal dose ke 0.5-1 g 1 nako / letsatsi, nako ea kalafo e ipapisitse le lipontšo.

0.5 ml ea tharollo ea ente ka bongata ba 500 mg / 5 ml e tsamaisoa ka mokhoa o hlakileng matsatsi a 10.

Litaelo tse khethehileng

Sebelisa ka hloko ka mafu a sebete le / kapa a liphio, haholo-holo ka nako e telele.

Boiphihlelo ba lilemo tse ngata kalafong ea lefu la sethoathoa le makhopho a sa sisinyeheng le mafapheng a pelo a bontšang hore meldonium ha se kalafo ea mohato oa pele bakeng sa lefu la sethoathoa.

Ho sebelisana le lithethefatsi

Ha e kopantsoe, meldonium e ntlafatsa ts'ebetso ea lithethefatsi tsa antianginal, lithethefatsi tse ling tsa antihypertensive, glycosides ea pelo.

Ka ts'ebeliso e ts'oanang ea meldonium e nang le nitroglycerin, nifedipine, alpha-blockers, li-antihypertgency agents le li-vasodilators tsa peripheral, tachycardia e leka-lekaneng, hypotension ea arterial e ka hlaha (ka mekhoa ena, ho hlokahala tlhokomeliso).

Mokhoa oa ketso

Setlhare ke analog ea maiketsetso ea γ-butyrobetaine. E na le tšusumetso e kholo ho motsoako oa carnitine le ho sisinyeha ha mafura acid ka marako a sele, mme e thibela ho bokelloa ha lintho tse tlisoang ke acetyl coenzyme le acyl carnitine liseleng.

Pharmacodynamics ea moriana o kenyelletsa keketseho ea boemo ba ts'ebetso.

Ka kalafo ea ischemia, lithethefatsi li etsa hore ho tsamaisoa ha oksijene / tšebeliso ea lisele ke li cell, li thibela ho sisinyeha ha ATP le ho kenya tšebetsong glycolysis. Ka ho fokotsa boemo ba carnitine, lithethefatsi li ntlafatsa ho potoloha ha gamma-butyrobetaine, e nang le phello ea vasodilating. Pharmacodynamics ea lithethefatsi e kenyelletsa keketseho ea boemo ba ts'ebetso, ho fokotsa litlamorao tsa khatello ea maikutlo / ea kelello, le ho ntlafatsa ho itšireletsa ha mmele / lithaelese.

Ka mefuta e matla ea ischemia, lithethefatsi li thibela ts'ebetso ea myocardial le mekhoa ea necrotic, hammoho le ho potlakisa ntlafatso. Ntle le moo, ts'oaroa ke methapo e kholo ea methapo le ho etsa hore e sebetse hantle ho eona mats'oao a amanang le ho tlohela joala.

Setlhare se ananeloa ho tsoa mala. Bioavailability ea eona e fihla ho 78%.

Khatiso e kholo ka mor'a ho tsamaisoa ka molomo e bonoa ka mor'a metsotso e 60-120.

Nakong ea biotransformation, lithethefatsi li etsa li-metabolites tse 'meleng. Ho felisoa ha halofo ea bophelo ke lihora tse 3 ho isa ho tse tšeletseng. Moriana o hlahisoa ke liphio.

Sebopeho le mofuta oa tokollo

Ha e rekisoa, moriana o fanoa ka tsela ea likhalase le tharollo ea ente.

Pilisi e 1 e na le:

• sesebelisoa se sebetsang (meldonium dihydrate) - 500 mg,
• likarolo tse ling: 27,2 mg ea starch ea litapole, 10,8 mg ea colloidal silicon dioxide, 5.4 mg ea calcium stearate,
• 'mele oa cap and capsule ke 98% ea gelatin le 2% titanium dioxide.

Ka har'a li-capsules ho na le phofo e tšoeu ea hygroscopic.

Ha e rekisoa, moriana o fanoa ka mokhoa oa likhabapo.

Tharollo e behiloe ka li-ampoules tse 5 ml, tse ka har'a lipakete tsa cell cell le mabokose a karete.

Litlamorao

Boitšoaro bo latelang ba 'mele ho moriana ona bo ka etsahala:

• allergies: ho ruruha, lekhopho, redness (ka seoelo),
• Phekolo ea ka mpeng: lipontšo tsa dyspeptic,
• CNS: ts'usumetso ea maikutlo a psychomotor,
• CVS: keketseho / ho fokotseha ha khatello ea mali, tachycardia (maemong a sa tloaelehang haholo).

Kamora tšebeliso ea lithethefatsi, lekhopho le ka etsahala.

Tekanyo ea joala

Karolo e sebetsang ea lithethefatsi e tlosoa ka nako e ka bang lihora tse 12. Kamora nako ena, kotsi ea karabelo e mpe ea tšebelisano ea lithethefatsi ka likarolo tse ling ha e eo kapa e nyane haholo.

Litaelo tsa tšebeliso ea lithethefatsi ha li thibele ho li kopanya le joala. Leha ho le joalo, haeba nako ea tsamaiso ea eona e etsoa ho phekola lefu lefe kapa lefe la methapo ea pelo kapa kotsi ea mokokotlo, mokuli o lokela ho qoba tšebeliso ea joala. Sena se bakoa ke kotsi ea ho fokotseha hoa ts'ebetso ea meriana. Motsoako o tšoanang o ka baka:

• lipontšo tse matla tsa allergic,
• tachycardia and angina pectoris,
• maemo a dyspeptic
• e tlola khatello ea mali.

Ha o sebelisa sethethefatsi sena le joala, ho ka hlaha khatello ea mali haholo.

Letsatsi la ho felloa ke nako

E seng lilemo tse fetang 4 ho tloha ka letsatsi la tlhahiso. Ho thibetsoe ho noa le ho enta moriana, letsatsi leo pheletso ea lona e felileng ka lona.

Ka linako tse ling, haeba moriana o le sieo kapa o sa tšoanelehe ka lebaka la li-contraindication, o ka ela hloko tse o nkelang sebaka.

Tse sebetsang ka ho fetisisa le tse tummeng ho tsona ke:

Ka lebaka la ho se be le karabelo e mpe nakong ea tsamaiso le ts'ebetso e matla, moriana o fumana litlhahlobo tse ntle haholo ho tsoa ho lingaka le bakuli. E kenya letsoho ts'ebetsong e eketsehileng ea ts'ebetso le ho hlaphoheloa ha matla.

Gennady Oprishchenko (therapist), ea lilemo li 40, Pushkino

Mefuta ka bobeli ea lithethefatsi (li-capsules le tharollo) e sebetsa ka mokhoa o ts'oanang ho matšoao a ho khaola, mathata a ho potoloha ho GM le li-pathologies tse ling. Bakuli ba khotsofetse ke theko e theko e tlase ea moriana le ho se be teng ha litla-morao.

Ekaterina Kolpakova (therapist), ea lilemo li 36, Yaroslavl

Ke fana ka moriana eseng feela oa batho ba kulang, empa le bakeng sa batho ba phetseng hantle (baatlelete) ho ntlafatsa ts'ebetso. E thusa hantle ha ba le tlas'a khatello ea maikutlo e phahameng le 'meleng. Litlamorao tsohle tsa mosebetsi oa ka ha li e-so ka li bonoa.

Stanislav Smirnov, ea lilemo li 41, Ryazan

Lithethefatsi li thusitse abuti oa ka hore a hlaphoheloe bokhobeng ba joala. Ngaka e laetsoe hammoho le matlapa a mang. Joale mor'abo rōna o ile a fumana mosebetsi 'me a phela bophelo bo botle.

Inga Stepanenko, ea lilemo li 38, Sergiev Posad

Moriana o noele o nooa haeba o hloleha ho potoloha ha 'mele. Matla a matla a hlaha kapele, ho ba sieo ha litlamorao ho ke ke ha thabisa. Ho joalo, 'me theko e theko e tlaase.

Tlhahlobo ea mamello

Ngaka e ile ea mpeha Melfor hore ke analogue ea theko e tlase ea moriana o mong. Kahoo o ile a nkopa - ho fana ka moriana o theko e phahameng o tsoang kantle kapa oa lapeng.Hobaneng ha ke hloka tlhahiso e theko e boima? Bakeng sa likhoeli tse 'maloa hona joale, ke laetsoe' na 'me ho na le phello e itseng: ho bile bonolo ho tsamaea, litlhaselo tsa angina ha li na ho ba teng. Ka kakaretso, ke thabile haholo ke Melfor. Liteboho tse khethehileng ho lingaka tse utloisisang hore ba tlohelang mosebetsi ba ka se be le chelete ea lithethefatsi tse tsoang kantle ho naha mme ba ba fa khetho ea ho etsa!

Tlhaloso e khutšoane

Analogue ea ka tlung ea "ronronate "ke moriana o sebetsang oa" meldonium "- sethethefatsi se matla se khothalletsang phallo ea metabolism le ho ntlafatsa phepelo ea matla ea lisele. E thibela ho kenella mitochondria ea mafura acids a mahala, ka tsela eo e fokotsa sekhahla sa oxidation sa ho qetela. Melfore e thibela ho tsamaisoa ha mafura a mangata ka li-membochondrial membranes, leha ho le joalo, e sebetsa ntlheng ena ka mokhoa o ikhethileng, ha e fetise feela li-acid tse telele tsa ketane. Ha e le ba liketane tse khutšoane, ba ka kenella ka bolokolohi ho mitochondria mme ba etsa eng kapa eng eo ba e ratang moo (pele ho tsohle, re bua ka oxidation ea bona). Ho fapana le trimetazidine, Melfore ha e bake ho bokelloa ha mafura a tlase-oxidised kahare ho mitochondria. Khahlano le nalane ea ischemia, lithethefatsi li khutlisetsa botsitso linthong tsa ho tsamaisa oksijene ho lisele le ho li sebelisa libakeng tsa pelehi. Ka nako e ts'oanang, anaerobic glycolysis ea matlafala. Tlas'a ketso ea melphor, vasodilator ea gamma-butyrobetaine e qala ho ikatisa ka mafolofolo. Setlhare se ntlafatsa ts'ebetso, ka tsela e itseng se fokotsa matšoao a ho tepella 'meleng le ho fetella kelellong, ho ntlafatsa boemo ba' mele ba ho itšireletsa mafung le ho itšireletsa mafung, 'me se na le phello ea pelo. Ka tšenyo e mpe ea ischemic ho mesifa ea pelo, Melfor e fokotsa boholo ba necrosis, e potlakisa ntlafatso. Ka ho haella ha ts'ebetso ea pelo, e eketsa ts'ebetso ea mesifa ea pelo, e ntlafatsa mamello ea ho ikoetlisa 'meleng, hape e fokotsa kotsi ea angina pectoris. Ka lefu la ischemia la mokokotlo, ho qhibiliha ho ntlafatsa phallo ea mali ho ischemic foci, ho lebisa phallo ea mali haholo-holo libakeng tsa ischemic. Motho a ke ke a hloleha ho hlokomela molemo o totobetseng oa ho sebelisa Melfor bakeng sa pathologies ea fundus (vascular le dystrophic).

Setlhare se ka sebelisoa hape kalafong e rarahaneng ea bakuli ba nang le joala bo sa foleng: e ts'oarisa tsamaiso ea methapo e kholo mme e tlosa litlamorao tsa ts'ebetso ea ts'ebetso ho eona. Lenane la litlamorao tse ntle tsa Melfor ha le felle feela ho sena: mohlala, sethethefatsi se bonts'a phello ea antioxidant, ho thibela lipid peroxidation le ho kenya ts'ebetso li-antioxidants tsa morao-rao, ka lebaka leo litlamorao tsa khatello ea oxidative li felisoang. Lithutong tsa bongaka, bokhoni ba Melfor ba ho ama hantle mesebetsi ea endothelium le ho laola molumo oa methapo ea mali bo ile ba netefatsoa. Ntle le moo, ho ile ha fumaneha hore moriana o boetse o na le litlamorao tse ling tsa mokokotlo: mohlala, o tlosa li-spasms tsa adrenal le angiotensin, mme o fokotsa ho hanyetsoa ha methapo ea pelo. Ntle le moo, ho qhibiliha ho eketsa kutloisiso ea lisele tsa mmele ho insulin, ho laola metabolism ea lipids le glucose.

Melfor e fumaneha ka mefuta e 'meli ea litekanyetso: li-capsules le tharollo ea ente. Ho bohlokoa hore o noe moriana hoseng, joalo ka e ka ba ntho e thabisang. Tekanyetso e beoa ke ngaka ka bonngoe. Ho latela likhothaletso tse akaretsang tsa tsamaiso ea molomo, lethal dose le le leng la Melfor ke 0,25-1 g, khafetsa ea tsamaiso le nako ea ketsahalo ea lithethefatsi li khethoa ke matšoao a itseng. Ka tsamaiso ea methapo, litekanyetso tsa letsatsi le letsatsi tsa moriana li 0.5-1 g, e fanoa ka nako. Parabulbar (ka letlalo la eyelid e tlase) Melfor e tsamaisoa ka 0.5 ml matsatsi a 10. Qetellong, polelo ea bohlokoa: ha lithuto tsa bongaka le boiphihlelo ba ho phekola lefu le sa foleng la makhopho a sefahleho li bontsitse, Melfor ha se khetho ea pele ho lefu le matla la coronary.

Thutela-litso

Metabolism enhancer, analogue ea gamma-butyrobetaine. E sitisa gamma-butyrobetaine hydroxynase, e thibela motsoako oa carnitine le ho tsamaisoa ha li-acids tse telele tsa ketane ka li-membrane tsa sele, mme e thibela ho bokellwa ha mefuta ea ts'ebetso ea li-acid tse mafura liseleng - tse tsoang ho acylcarnitine le acylcoenzyme A.

Tlas'a maemo a ischemia, e khutlisetsa tekanyo ea ts'ebetso ea phepelo ea oksijene le ts'ebeliso ea eona liseleng, e thibela tlolo ea tsamaiso ea lipalangoang tsa ATP, mme ka nako e ts'oanang e kenya ts'ebetso ea glycolysis, e tsoelang pele ntle le ts'ebeliso ea oksijene ea oksijene. Ka lebaka la ho fokotseha ha khatello ea carnitine, gamma-butyrobetaine e nang le thepa ea vasodilating e entsoe ka matla. Mokhoa oa ts'ebetso o khetholla phapang ea litlamorao tsa eona tsa pharmacological: ts'ebetso e matlafatsang, ho fokotsa matšoao a khatello ea kelello le ea 'mele, ts'ebetso ea ts'ebetso ea tishu le ho se sireletsehe ha mmele, phello ea pelo.

Tabeng ea tšenyo e mpe ea ischemic ho myocardium, e liehisa sebopeho sa tikoloho ea necrotic mme e khutsufatsa nako ea ntlafatso. Ka ho nyekeloa ke pelo, e eketsa ts'ebetso ea myocardial, e eketsa mamello, hape e fokotsa leqhubu la litlhaselo tsa angina. A a hlobaetsang le a sa foleng a ischemic mathata a ho potoloha ha litho tsa mali a mali ho ntlafatsa phallo ea mali ka leihlo la ischemia, le kenya letsoho ho abolleloeng ha mali molemong oa sebaka sa ischemic. E sebetsa hantle bakeng sa methapo ea methapo ea methapo le ea methapo ea methapo. E na le tšusumetso ea tonic tsamaisong ea methapo e bohareng, e tlosa litšitiso tse sebetsang tsa tsamaiso ea methapo ho bakuli ba nang le joala bo sa foleng ba nang le lefu la ho khaotsa.

Mofumahali

Kamora ho tsamaisoa ka molomo, e kenella ka potlako ho tsoa mokokotlong oa lijo. Bioavailability e ka ba 78%. C_max ho plasma e fihlella ka mor'a lihora tse 1-2 ka mor'a taolo. E biotransformed 'meleng ka sebopeho sa metabolites tse peli tse kholo tse epolotsoeng ke liphio. T_1/2 ke lihora tse 3-6 mme ho latela tekanyetso.

Tšebelisano ea Melfor le lithethefatsi tse ling

Kotsi ea ho ba le arterial hypotension le tachycardia e itekanetseng e hlaha ka lebaka la tšebeliso e tšoanang ea Melfort le lithethefatsi tse latelang:

• li-vasodilators tsa paramente,
• alpha adrenergic blockers,
• antihypertgency agents
• nifedipine
• nitroglycerin.

Ntle le moo, ha e sebelisoa hammoho le glycosides ea pelo, lithethefatsi tsa antianginal, hammoho le mefuta e meng ea lithethefatsi tse antihypertensive, phello ea tsona ea phatlalatsoa.

Bongata

Tabeng ea ho nka litekanyetso tse eketsehileng tsa moriana, maikutlo a bofokoli bo akaretsang, hlooho ea hlooho le ho tsekela, nts'etsopele ea tachycardia, le ho fokotseha ha khatello ea mali ho ka hlaha. Kaha moriana ona o na le chefo e fokolang, lipontšo tsohle tse sa rateheng li nyamela kapele ka mor'a kalafo e tloaelehileng ea matšoao.

Lipehelo le maemo a polokelo

Bophelo ba setebele sa lithethefatsi Melfor ke likhoeli tse 24 ho tloha ka letsatsi leo a lokolloang ka lona. E boloke sebakeng se omileng le se lefifi se sa fumaneheng ho bana.

Mocheso oa moea ha oa lokela ho feta likhato tse 25 tsa Celsius.

Moriana oa lithethefatsi oa fumaneha litlhare tsa meriana tse fumanehang. Litšenyehelo tsa eona tse tloaelehileng Russia ke li-ruble tse 500-560.

Lifekthering tsa Seukraine U ka reka moriana oa Melfor ka theko ea 200 ho isa ho 250 hryvnia.

Maemong a mang, haeba moriana oa lithethefatsi Melfor o sa tšoanelehe, kapa ho se na monyetla oa tšebeliso ea ona, o lokela ho ela hloko tse nkang sebaka tse sebetsang hantle haholo.

Litšoantšo tse tsebahalang haholo tsa Melfora li kenyelletsa:

• Magnikor - tokisetso e thehiloeng ho acetylsalicylic acid le magnesium hydroxide, e etselitsoeng ho phekola lefu la pelo le matla ka sebopeho se matla le se sa foleng,
• Pumpan - e leng moriana o sebelisang marotholi le matlapa bakeng sa kalafo e rarahaneng ea lefu la methapo ea methapo, ho nyekeloa ke pelo, arrhythmia le mafu a mang a pelo.
• Cordaflex - matlapa a hlafunang a nang le motsoako o ka sehloohong o sebetsang oa nifedipine. Setlhare sena se laetsoe "angina pectoris" e tsitsitseng, khatello ea methapo ea mali, lefu la pelo le matla le khatello ea methapo ea mali, e nang le bothata bo fapaneng.
• Corvitol - matlapa a nang le metoprolol. Li sebelisetsoa ho phekola lefu la pelo, corrary infarction, angina pectoris, hyperthyroidism, khatello e matla ea mali le pelo.
• Kudesan ke lithethefatsi ka mokhoa oa marotholi le matlapa a thehiloeng ho ubidecarinone. Matšoao a ka sehloohong a ts'ebeliso ea 'ona ke lefu la pelo, ho nyekeloa ke pelo, nako ea ho phomola le nako ea ho hlaphoheloa kamora ho hlaseloa ka leeme.
• Amlipin ke sethethefatsi se kopaneng se thehiloeng ho lisinopril le amlodipine, se etselitsoeng ho phekola lefu la pelo le methapo ea methapo ea methapo ea methapo e fapaneng.
• Bisoprol - matlapa a thehiloeng hodima bisoprol fumarate, a etselitsoeng ho phekola angina pectoris, pelo e sa foleng le ho nyekeloa ke khatello ea mali ea methapo.

Ka lebaka la ts'ebetso ea eona e phahameng le ho ba sieo ha litlamorao, lithethefatsi Melfor e fumana litlhahlobo tse ntle ho bakuli le lingaka. Lintlha li ka fumanoa qetellong ea sengoloa sena.

Batho ba nkileng bongaka ba hore e na le litlamorao ho boemo ba tsamaiso ea methapo ea pelo le lits'ebetso tsa ho potoloha ha lets'ollo. E boetse e thusa ho potlakisa matla a matla le ho eketsa katleho.

Haeba u na le boiphihlelo ba hau ba kalafo ka ts'ebeliso ea lithethefatsi Melfor, etsa bonnete ba hore u arolelana maikutlo a hau le baeti ba bang sebakeng sena, ba siea tlhahlobo.