Rosinsulin P, S, M

Hypoglycemic agent, insulin e nkang nakoana. Ho sebelisana le li-receptor tse ikhethang ho membrane e ka ntle ea lisele, ho etsa motsoako oa "insulin" receptor. Ka ho eketsa motsoako oa cAMP (liseleng tsa mafura le lisele tsa sebete) kapa ho kenella ka ho toba ka seleng (mesifa), motsoako oa "insulin" o hlohlelletsa lits'ebetso tse kahare ho eona, ho kenyeletsa synthetise ea li-enzyme tse 'maloa tsa bohlokoa (ho kenyeletsa hexokinase, pyruvate kinase, glycogen synthetase).

Ho fokotseha ha tekanyo ea tsoekere maling ho bakoa ke keketseho ea lipalangoang tsa eona tse ka hare, ho eketsoa ho eketsehileng le ho ts'oaroa ke lisele, ho hlohlelletsoa hoa lipoisis, glycogenogeneis, synthesis ea protheine, le ho fokotseha ha sekhahla sa tlhahiso ea tsoekere ke sebete (ho fokotseha ha ho phatloha ha glycogen).

Ho qala ketso ke kamora metsotso e 30, phello e kholo ke kamora lihora tse 1-3, nako ea tšebetso ke lihora tse 8.

Melemo ea litekanyetso

Tekanyetso le tsela ea tsamaiso ea moriana e khethoa ka bonngoe maemong ka seng ho latela lethathamo la tsoekere maling maling pele ho lijo le lihora tse 1-2 kamora ho ja, hape ho latela tekanyo ea glucosuria le litšobotsi tsa nako ea lefu lena.

E le molao, s / c e fanoa metsotso e 15-20 pele ho lijo. Litsi tsa ente e fetoloa nako le nako. Haeba ho hlokahala, tsamaiso ea IM kapa IV e lumelloa.

E ka kopanngoa le li-insulin tse nkang nako e telele.

Litla-morao

Boitlhotlhollo ba ho kulisa: urticaria, angioedema, feberu, ho hema hanyane, ho fokotse khatello ea mali.

Ho tloha tsamaisong ea endocrine: hypoglycemia e nang le lipontšo tse kang pallor, ho fufuleloa ho eketsehileng, palpitations, likhathatso tsa boroko, ho thothomela, mathata a methapo, tšitiso ea methapo ea mali le insulin ea motho, keketseho ea karolo ea lithibela-mafu tsa anti-insulin ka keketseho e latelang ea glycemia.

Ho tloha lehlakoreng la setho sa pono: ho fokola ha nakoana ponong (hangata qalong ea kalafo).

Boitšoaro ba lehae: hyperemia, ho hlohlona le lipodystrophy (atrophy kapa hypertrophy ea mafura a tlotsitsoeng) sebakeng sa ente.

Tse ling: qalong ea kalafo, edema ea khonahala (feta ka kalafo e tsoelang pele).

Bokhachane le pelehi

Nakong ea kemolo, ho hlokahala hore ho nahane ka ho fokotseha ha tlhoko ea insulin ho trimester ea pele kapa keketseho ea li-trimesters tsa bobeli le tsa boraro. Nakong ea ha lesea le hang kamora ho hlaha, litlhoko tsa insulin li ka theoha haholo.

Nakong ea ho nyekeloa, mokuli o hloka ho hlahlojoa letsatsi le leng le le leng ka likhoeli tse 'maloa (ho fihlela ho tsitsa ha tlhoko ea insulin).

Litaelo tse khethehileng

Ka hlokolosi, khetho ea lithethefatsi ea meriana e etsoa ho bakuli ba nang le mathata a ho kula a amanang le ho ruruha ho ea ka mofuta oa ischemic le mefuta e matla ea lefu la pelo.
Tlhokahalo ea insulin e ka fetoha maemong a latelang: ha o fetohela ho mofuta o mong oa insulin, ha o fetola lijo, lets'ollo, ho hlatsa, ha o fetola bonyata ba tloaelo ea ho ikoetlisa 'meleng, mafu a liphio, sebete, pituitary, tšoelesa ea qoqotho.
Ho hlokahala hore ho lokisoe lethalamo la insulin bakeng la maloetse a tšoaetsanoang, ho se sebetse ha qoqotho ea qoqotho, lefu la Addison, hypopituitarism, ho se atlehe ha renal, le lefu la tsoekere ho bakuli ba lilemo tse fetang 65.

Phetisetso ea mokuli ho insulin ea batho e lokela ho lula e lokafatsoa ka nepo le ho etsoa feela ka taolo ea ngaka.

Lisosa tsa hypoglycemia e ka ba: ho ba le insulin e ngata, ho kenya lithethefatsi, ho tlola lijo, ho hlatsa, lets'ollo, khatello ea mmele, mafu a fokotsang tlhoko ea insulin (mafu a liphio le a sebete, hammoho le hypofunction ea adrenal cortex, pituitary kapa gland ea tšoelesa). (mohlala, letlalo le ka mpeng, mahetleng, serope) hammoho le ho sebelisana le lithethefatsi tse ling. Ho a khonahala ho fokotsa khatello ea "glucose" e ngata maling ha o fetisetsa mokuli ho tsoa ho insulin ea motho.

Mokuli o lokela ho tsebisoa ka matšoao a lefu la hypoglycemic, ka matšoao a pele a ho ba le lefu la tsoekere le ka tlhoko ea ho tsebisa ngaka ka liphetoho tsohle maemong a hae.

Tabeng ea hypoglycemia, haeba mokuli a le hlokolosi, o fuoa dextrose ka hare, s / c, i / m kapa iv e kentsoeng glucagon kapa iv solution ea hyperonic dextrose. Ka nts'etsopele ea komello ea hypoglycemic, 20-40 ml (ho fihlela ho 100 ml) ea tharollo ea dextrose 40% e kenngoa ka har'a molatsoana ho fihlela mokuli a akheha.

Bakuli ba nang le lefu la tsoekere ba ka emisa hypoglycemia e nyane eo ba e utloang ka ho ja tsoekere kapa lijo tse nang le lik'habohaedreite tse ngata (bakuli ba khothalletsoa hore ba be le bonyane 20 g ea tsoekere le bona).

Ho mamella joala ho bakuli ba fumanang insulin hoa fokotseha.

Tšusumetso ho bokhoni ba ho khanna makoloi le litsamaiso tsa taolo

Tšekamelo ea ho ba le hypoglycemia e ka fokolisa bokhoni ba bakuli ba ho khanna makoloi le ho sebetsa ka mekhoa.

Ho sebelisana le lithethefatsi

Phello ea hypoglycemic e ntlafatsoa ke li-sulfonamides (ho kenyeletsa le lithethefatsi tsa molomo tsa hypoglycemic, sulfonamides), li-inhibitors tsa MAO (ho kenyeletsoa furazolidone, procarbazine, selegiline), carbonic anhydrase inhibitors, li-inhibitors tsa ACE, li-NSAIDs (ho kenyeletsa le salicylides), anabolic (ho kenyelletsa stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, litokisetso tsa lithium, pyridoxine, quinidine, quinine, etinine, etline.

Glucagon, GCS, histamine H 1 li-receptor blockers, lithibela-pelehi tsa molomo, li-estrogens, thiazide le "loop" diuretics, li-blockers tse liehang tsa calcium, li-sensathomimetics, lihomone tsa qoqotho, li-antidepressants tsa hepatin, morphine diazropin li fokotsa phello ea hypoglycemic. , matekoane, nikotini, phenytoin, epinephrine.

Beta-blockers, reserpine, octreotide, pentamidine ka bobeli li ka ntlafatsa le ho fokotsa phello ea hypoglycemic ea insulin.

Ts'ebeliso e ts'oanang ea beta-blockers, clonidine, guanethidine kapa reserpine e ka pata matšoao a hypoglycemia.

Ka meriana ha a lumellane le tharollo ea lithethefatsi tse ling.

Fomu ea tokollo, sebopeho le sephutheloana

E fumaneha ka mefuta e meraro:

1. P - tharollo e nkang lintho hakhutšoanyane, e se nang mebala ebile e hlakile.
2. C - nako e mahareng, ho emisoa ha 'mala o mosoeu kapa o motala.
3. M - kopanya 30/70, mekhahlelo e 'meli. Medi e nang le ts'ebetso e potlakileng ea ho qala, ho emisoa.

Moetso o kenyelletsa:

• 100 IU ea inshorense ea tlhaho ea motho,
• protamine sulfate,
• sodium hydrogen phosphate dihydrate,
• krystalline phenol,
• metacresol
• glycerol (glycerin),
• metsi bakeng sa ente.

Ba ananelang sebopeho ba fapana ka ho hlaka mohuta o mong le o mong. Rosinsulin M e na le biphasic insulin - soluble + isophane.

E fumaneha ka libotlolong (likotoana tsa 5 ml) le li-cartridge (5 likotoana tsa 3 ml).

Mofumahali

Type P e qala ho sebetsa halofo ea hora kamora ho ente, tlhoro - lihora tse 2-4. Ho nka lihora tse 8.

Mofuta oa C o hlahisoa ka mor'a lihora tse 1-2, tlhoro e ba teng lipakeng tsa 6 le 12. Phello e fela ka letsatsi.

M e qala ho sebetsa halofo ea hora, tlhoro ke 4-12, ketso e fela ka lihora tse 24.

E senngoa ke insulinase lipelong le sebete. E hloekisoa ke liphio. Ke liente tsa subcutaneous feela tse lumelloang ka botsona.

• Mefuta ka bobeli ea lefu la tsoekere
• Lefu la tsoekere ho basali baimana
• Maloetse a nakong
• Tlatsetso ea lithethefatsi tsa molomo tsa hypoglycemic.

Litaelo tsa ho sebelisoa (mokhoa le litekanyetso)

Mokhoa o ka sehloohong oa tsamaiso ke ente ea subcutaneous. Tekanyetso e khethoa ka bonngoe ho ipapisitse le bopaki le litlhoko tsa mmele. Sebaka sa ente se na le maratsoana, letheka, mpa, mahetla. U lokela ho fetola sebaka sa ente nako le nako.

Tekanyetso e tloaelehileng ea letsatsi le letsatsi ke 0.5-1 IU / kg.

"Rosinsulin R" e sebelisoa halofo ea hora pele ho lijo. Palo ea liente e laetsoe ke ngaka.

Litlamorao

• Karabelo ea lehae le tsamaiso
• Hypoglycemia,
• Ho akheha ho fihlela ho akheha,
• Phokotso ea BP
• Hyperglycemia le lefu la tsoekere,
• Keketseho ea karolo ea lithibela-mafu tse thibelang insulin, e lateloe ke keketseho ea glycemia,
• Ho sitisoa ha pono
• Karabelo ea mafu a amanang le tšoaetso ea mali le insulin ea motho,
• Hyperemia,
• Lipodystrophy,
• Ho ruruha.

Bongata

Mohlomong nts'etsopele ea hypoglycemia. Matšoao a eona: tlala, pallor, ho akheha ka lebaka la ho akheha, ho nyekeloa ke pelo, ho hlatsa le ba bang. Foromo e bobebe e ka tlosoa ka ho ja lijo tse tsoekere (pompong, sekhechana sa tsoekere, mahe a linotsi). Ka mefuta e itekanetseng le e matla, ho tla hlokahala ente ea glucagon kapa tharollo ea dextrose, kamora - lijo tse nang le lik'habohaedreite. Etsa bonnete ba hore joale o ea ngakeng ho fumana tokiso ea litekanyetso.

Ho bapisoa le li-analogues

Rosinsulin e na le lithethefatsi tse 'maloa tse tšoanang, tseo ho leng bohlokoa hore u li tsebe ho bapisa thepa.

Novomiks. Insulin aspart, mekhahlelo e 'meli. E Entsoe ke Novo Nordisk ho la Denmark. Theko - ho fihlela ho li-ruble tse 1500. bakeng sa ho paka. Tšusumetso ea nako e mahareng, e potlakile ebile e sebetsa. Moriana ha o lumelloe ho bana ba ka tlase ho lilemo tse 6, mme o laetsoe ka tlhokomeliso nakong ea kemolo le botsofe. Karabelo ea lintho tsohle tse amanang le lefu la setsi sa ente se fumanehang.

"Insuman." Insulin ea motho, mefuta e meraro ea ketso. Ho hloka li-ruble tse 1100. Mohlahisi - "Sanofi Aventis", Fora. E sebelisoa bakeng sa kalafo ea batho ba baholo le ba bana. Ka seoelo se baka litlamorao. Molekane o motle.

"Protafan." Hape insulin ea motho ke mofuta o entsoeng ka liphatsa tsa lefutso. Cheeki - li-ruble tse 800. bakeng sa li-cartridge, tharollo - li-ruble tse 400. E Entsoe ke Novo Nordisk, Denmark. E fanoa feela ka tsela e sa sebetseng, e sebelisetsoa ho phekola bakuli ba lilemo life kapa life. Ho a khonahala bakeng sa basali ba baimana le ba lactating. Molekane ea theko e tlaase le ea theko e tlase.

"Biosulin." Isulin insulin. Moqapi - Pharmstandard, Russia. Litšenyehelo li ka ba li-ruble tse 900. (mabokose). Ke ketso ea nako e mahareng. E ka sebelisoa ho phekola bakuli ba lilemo tsohle.

Humulin. Ke insulin e qhibilihang ka tlhaho. Theko - ho tloha ho li-ruble tse 500. bakeng sa libotlolo, mabokose a theko e boima haholo habeli. Likhamphani tse peli li hlahisa sehlahisoa sena hang-hang - Eli Lilly, USA le Bioton, Poland. E sebelisoa bakeng sa lihlopha tsohle tsa lilemo, ho basali baimana ba nang le lefu la tsoekere. Batho ba baholo ba lokela ho sebelisoa ka hloko. E fumaneha likhoebong tsa meriana le ka melemo.

Qeto ea ho fetisetsa mokuli ho ea mofuta o mong oa phekolo ea meriana e etsoa ke ngaka e eang. Ho ikoetlisa ho thibetsoe!

Ha e le hantle, batho ba nang le lefu la tsoekere ba nang le boiphihlelo ka moriana ona ba na le maikutlo a matle. Ho sebelisa ts'ebeliso habonolo, bokhoni ba ho kopanya mefuta e mengata bo hlokomelehile. Empa ho na le batho bao pheko ena e neng e sa ba tšoanele.

Galina: “Ke lula Yekaterinburg, ke ntse ke phekoloa lefu la tsoekere. Haufinyane tjena ke amohela melemo ea Rosinsulin. Ke rata lithethefatsi, li sebetsa hantle. Ke kenya kopo e khuts'oane le e mahareng, tsohle li tšoaneleha. Ha ke fumana hore ena ke setlhare sa lapeng, ke ile ka makala. Boleng ha bo khethollohe ho motho oa kantle ”.

Victor: “Ke ile ka tšoaroa ke Protafan. Ngaka e ile ea eletsa moriana o entsoeng ka theko e tlaase haholoanyane oa Russia, Rosinsulin. E se e le likhoeli tse 'maloa ke e sebelisa, ke thabile ka tsohle. Tsoekere e na, ha e na litla-morao, ha e bake hypoglycemia. Haufinyane tjena ke qalile ho fumana melemo, e leng se thabisang haholo. ”

Vladimir: "Humalog" e sebelisitsoeng "le" Humulin NPH. " Ka nako e 'ngoe, li ile tsa nkeloa sebaka ke Rosinsulin bakeng sa melemo. Ke sebelisa e khutsoanyane le e mahareng. Ho u joetsa 'nete, ha kea ka ka hlokomela phapang efe kapa efe e ikhethang ho lithethefatsi tse fetileng. Tsoekere e lokile, ha ho na hypoglycemia. Le methati ea tlhahlobo e ile ea ntlafala. Kahoo ke eletsa sethethefatsi sena, u se ke ua tsaba hore ke Serussia - lisebelisoa le lisebelisoa tse tala, joalo ka ha ngaka ea ka e boletse, ke tsa kantle ho naha, tsohle li ka melao. Mme phello e molemo le ho feta. "

Larisa: “Ngaka e ile ea isoa Rosinsulin. E ile ea phekoloa likhoeli tse 'maloa, empa butle-butle liteko li ile tsa mpefala. Le lijo ha lia ka tsa thusa. Ke ile ka tlameha ho fetohela ho mokhoa o mong, eseng molemong oa chelete, empa bakeng sa chelete ea ka. Ke lihlong, hobane lithethefatsi li ka theko e tlase ebile li maemong a holimo. "

Anastasia: “O ngolisa hape le lefu la tsoekere. Ba file Rosinsulin mokhoa o mahareng e le kalafo. Nakoana o sebelisa Actrapid. Ke utloile ho ba bang hore o thusa hantle, empa lapeng ha ke e-so fumane phetoho ea maemo a itseng. Ke batla ho botsa ngaka hore e fetisetse moriana o mong, hobane haufinyane ho bile le tlhaselo ea hypoglycemia. Mohlomong ha e tšoanele, ha ke tsebe. ”