Glibenclamide: litaelo tsa tšebeliso ea moemeli oa hypoglycemic

Glibenclamide ke lithethefatsi tse tsoang ka molomo tse amanang le "derivatives" sulfonylureas. Mochini oa ts'ebetso oa glibenclamide o kenyelletsa ho hlohlelletsa secretion insulin β lisele tse ho manyemeka ho eketsa ho lokolloa ha insulin. Haholo, ho sebetsa hantle ho bonahala mohatong oa bobeli oa tlhahiso ea insulin. Sena se eketsa kutloisiso ea lisele tsa pherite ho ea ketsong ea insulin, hammoho le khokahano ea eona le lisele tsa sepheo. Ho feta moo, glibenclamide e tšoauoa ka phello e tlase ea lipid le ho fokotseha ha thepa ea thrombogenic madi.

Ka hare ho mmele, ho monya ntho ka potlako le ho tsoa ka botlalo ho tsoa ho tšilo ea lijo ho ile ha hlokomeloa. Puisano le liprotheine tsa plasma li tšoana le hoo e ka bang 95%. Metabolism sethethefatsi se etsoa ka har'a sebete, ho etsa hore ho se sebetse letho metabolites. Excretion e etsahala haholo ha ho etsoa moroto le karolo - bile, ka sebopeho sa metabolites.

Contraindication

Setlhare ha se khothalletsoe ho sebelisoa le:

• Hypersensitivityto Glibenclamide kapa sulfonamides le thiazide diuretics,
• lefu la tsoekere le makhethe kapa lekhopho,
• ketoacidosis,
• ho chesa haholo
• likotsi le mehato ea ho buoa,
• mala le mala a ka mpeng,
• mefuta e fapaneng ea malabsorption ea lijo,
• ntshetsopele hypoglycemia,
• ho nyeka, ho ima,
• lefu la tsoekereMofuta oa 1 joalo-joalo.

Litlamorao

Ka kalafo le Glibenclamide, nts'etsopele ea matšoao a sa batleheng a amang mosebetsi oa endocrine, tšilo ea lijo, methapo ea kutlo, tsamaiso ea methapo le hematopoietic ea khonahala. Ka hona, ho ka etsahala: hypoglycemiamaemo a fapaneng a boima ho nyekeloa ke pelo, lets'olloho se sebetse hantle ha sebete, cholestasis, hlooho e bohlokobofokoli le mokhathala ho tsekela.

Ponahatso ea ho kula le maemo a dermatological ka mokhoa oa: lekhopho la letlalo, ho hlohlona, ​​photosensitization le matšoao a mang ho ka etsahala.

Litaelo tsa ho sebelisoa Glibenclamide (Mokhoa le litekanyetso)

Litaelo tsa tšebeliso Glibenclamide e tlaleha hore tekanyetso ea moriana e behiloe ka bonngoe mme ho latela lilemo, botebo ba lefu lena le boemo glycemia. Matlapa a nooa ka molomo, ka mpeng e se nang letho kapa lihora tse peli kamora ho ja.

Tekanyetso e tloaelehileng ea letsatsi le letsatsi e behiloe ka bongata ba 2,5-15 mg, le khafetsa ea tsamaiso makhetlo a 1-3 ka letsatsi.

Litekanyetso tsa letsatsi le letsatsi tse kaholimo ho 15 mg ha li sebelisoe hangata, ha ho na keketseho e kholo ea phello ea hypoglycemic. Bakuli ba tsofetseng ba fuoa tekanyetso ea letsatsi le letsatsi ea 1 mg qalong ea kalafo. Liphetoho tsohle ho tloha ho sethethefatsi se seng ho ea ho se seng, ho qhekella ha litekanyetso le tse ling, li tlameha ho etsoa ka taolo ea setsebi.

Bongata

Haeba ho na le overdose, nts'etsopele ea hypoglycemia e ka etsahala, e ka tsamaeang le maikutlo a tlala, bofokoli, ho ameha, hlooho e bohloko, ho tsekela, mofufutso, ho otla ha peloho thothomela hoa mesifa boko edemapuo le ho hloka pono ea pono le tse ling.

Phekolo e kenyelletsa ho ja tsoekere ka potlako, lero la litholoana, tee e chesang e chesang, sirapo ea poone, mahe a linotsi - maemong a bonolo.

Ho na le linyeoe tse ngata tse hlokang tharollotsoekere 50% infusion e tsoelang pele tharollo ea mothapo Dextrose 5-10%, kenyelletso Glucagon ka har'a methapo Diazoxide ka hare. Ntle le moo, o hloka ho laola boemo ba glycemia, ho tseba pH, creatinine, urea naetrojene, li-electrolyte.

Tšebelisano

Ho kopana le litla-morao tsa antifungal, fluoroquinolones, tetracyclines, chloramphenicol, H2-blockers, beta-blockers, ACE inhibitors le MAO,clofibrate, bezafibrate, probenecid, Paracetamol, ethionamide, anabolic steroids, pentoxifylline, allopurinol, cyclophosphamide, Reserpine, sulfonamide le Insulin e khona ho baka hypoglycemia.

Tšebeliso e kopanetsoeng le barbiturates, phenothiazines, diazoxide, li-glucocorticoid le lihormone tsa qoqotho, li-estrogens, li-gestagens, tsoekere, lithethefatsi tsa adrenomimetic, Litlolo tsa lithium tse tsoang nicotinic acid le saluretics e ka fokolisa phello ea hypoglycemic.

Mekhoa e ka matlafatsang moroto, mohlala: calcium chloride, chloride ea ammoniumtekanyetso e kholo asiti ea ascorbic e ka ntlafatsa litlamorao tsa moriana. Motsoako le Rifampicin potlakisa inactivation le ho fokotsa ts'ebetso ea eona.

Litaelo tse khethehileng

Ho khothalletsoa ho phekola ka hloko bakuli ba nang le bothata ba sebete le liphio, tse nang le maemo a mabe, ts'ebetso ea ts'ebetso ea methapo ea methapo ea methapo kapa "gland" le joala bo sa foleng.

Bakeng sa ts'ebetso ea bongaka e felletseng, ho lekola ka hloko boemo ba tsoekere maling le bokong ba tsoekere bo hlokahala.

Haeba hypoglycemia e hlaha ho bakuli ba hlokofetseng, joale tsoekere kapa tsoekere e fanoa ka molomo. Maemong a ho lahleheloa ke kelello, tsoekere e fanoa ka methapo, 'me glucagon - ka methati, ka kotlolloho kapa ka methati.

Ha kelello e hlaphoheloa, ka potlako mokuli o fuoa lijo tse nang le lik'habohaedreite ho qoba ho pheta-pheta hypoglycemia khafetsa.

Mefuta le sebopeho sa tokollo

Ho 1 tab. lithethefatsi tsa antidiabetesic li na le 1,75 mg, 3.5 mg kapa 5 mg ea motsoako o sebetsang, e leng glibenclamide.

Hape ho tsa bongaka ho teng:

• Povidone
• Lactose Monohydrate
• Litapole tsa litapole
• Magnesium stearate
• Ponceau 4R.

Matlapa a chitja ka 'mala o mosehla, o mopinki ka' mala, ho kanna ha ba le Splash. Setlhare sena se fumaneha ka botlolong ea khalase e nang le matlapa a 120, ho ts'oaroa bukana ea tataiso ea mosebelisi.

Pholiso ea thepa

Ho bohlokoa ho hlokomela hore lebitso la khoebo la lithethefatsi le tsamaisana le lebitso la karolo e sebetsang. Lithethefatsi li na le phello ea hypoglycemic ka bobeli ho batho ba nang le lefu la tsoekere la mofuta oa 2, le bathong ba phetseng hantle. Mochine oa ts'ebetso o ipapisitse le secretion e eketsehileng ea insulin ke lisele tsa β-li-pancreas ka lebaka la ts'usumetso ea eona e sebetsang. Phello e joalo, pele ho tsohle, e ea boemong ba tsoekere e bohareng e potileng lisele tsa β.

Kamora ho sebelisa pilisi, ntho e sebetsang e potlakile ebile e batla e ananeloa ka botlalo. Ka lijo, ha ho na phokotseho e kholo ea tekanyo ea ho kenngoa ha glibenclamide. Letšoao la puisano le liprotheine tsa plasma ke 98%. Khokahano e phahameng ka ho fetisisa ea ntho e serumeng e bonoa ka mor'a lihora tse 2,5. Ho fokotseha ha khatello ea glibenclamide ho tlalehiloe kamora lihora tse 8-10 mme ho latela tekanyo ea lithethefatsi tse nkuoeng ke mokuli. Ho felisoa ha halofo ea bophelo ke bolelele ba lihora tse 7.

Phetoho ea metabolism ea glibenclamide e etsahala liseleng tsa sebete, ho thehoa metabolites, tseo ha li sa nke karolo ho fokotseng tsoekere ea ntho e sebetsang. Excretion ea lihlahisoa tsa metabolic e etsoa ka moroto, hammoho le bile ka bongata bo lekanang, tlhahiso ea ho qetela ea metabolites e bonoa ka mor'a lihora tse 45-72.

Ho batho ba nang le bothata ba ho se sebetse hantle ha sebete, ho rekotoa mantle a glibenclamide. Ho bakuli ba nang le bothata ba ho phekoloa ke lipholisa, ho pepesetsoa ha metabolite e sa sebetseng ka kotloloho mokokotlong ho eketsa pompo ea bona.

Litaelo tsa ho sebelisoa ha matlapa

Theko: Ho tloha ho 56 ho isa ho 131 li-ruble.

Litekanyetso tsa lithethefatsi li khethoa ka bonngoe ho nahanela lilemo tsa mokuli, glycemia, le boima ba lefu lena. Ho kgothaletswa ho nwa dipilisi ka mpeng e se nang letho kapa kamora dihora tse 2 kamora ho ja.

Ka tloaelo, tekanyetso ea letsatsi le letsatsi e fapana pakeng tsa 2,5 mg - 15 mg. Khafetsa ea tšebeliso ea lipilisi ke 1-3 leq. letsatsi lohle.

Ho amoheloa ka tekanyetso ea letsatsi le letsatsi ea 15 mg mme ho ka holimo ho boletsoe hanyane haholo, sena ha se eke haholo phello ea moriana. Batho ba baholo ba khothalletsoa ho qala kalafo ka 1 mg ka letsatsi.

Phetoho ho tsoa ho setheo se le seng sa meriana e loantšang lefu la tsoekere ho ea ho se seng kapa phetoho ea litekanyetso tsa bona e lokela ho ba tlasa taolo ea ngaka.

Litlhokahalo tsa polokeho

Phekolo ea kalafo e lokela ho etsoa ka tlasa tlhahlobo ea kamehla ea tsoekere ea mali le moroto.

Nakong ea kalafo, o lokela ho hana ho noa lino tse tahang, hobane nts'etsopele ea hypoglycemia, hammoho le lipontšo tse kang disulfiram, ha e qheleloe ka thoko.

Ha matšoao a hypoglycemia a hlaha, ho tla hlokahala ho etsa tefo bakeng sa khaello ea tsoekere ka tsamaiso ea molomo ea dextrose. Sebakeng sa boemo ba ho se tsebe letho, dextrose e tsamaisoa ka matla. Ho qoba ho oela hape, ho bohlokoa ho ruisa lijo le lik'habohaedreite.

Sokolla foromo le sebopeho

Foromo ea litekanyetso - matlapa: flat-cylindrical, e nang le mohala o arohanang, o mosoeu kapa o mosoeu ka 'mala o bobebe kapa' mala o mosehla (li-pcs tse 10. Ka marang-rang, lebokoseng la karete ea 1, 2, 3 kapa 5, 20 ka makotikoti a entsoe ka polymer kapa khalase e lefifi, ka lebokoseng la mekotla e le 'ngoe 1).

Sesebelisoa se sebetsang ke glibenclamide, Letlapeng le le leng - 5 mg.

Likarolo tse thusang: lactose monohydrate (tsoekere ea lebese), magnesium stearate, povidone (boima ba molek'hule ea polyvinylpyrrolidone e tlase), starch ea litapole.

Mofumahali

Ha ho nkoa ka molomo, glibenclamide e ananeloa ho tsoa pampitšana ea ka mpeng ka 48-84%. Khokahanyo e phahameng ea ntho ena e fihlella ka mor'a lihora tse 1-2 ka mor'a tsamaiso. Bophahamo ba karolelano ea thepa ke li lithara tse 9-10. Glibenclamide e hokahana le liprotheine tsa plasma ka 95-99%. Bioavailability ea eona ke 100%, ka hona, moriana o ka nooa hang-hang pele ho lijo.

Glibenclamide e kenella hampe ka har'a sehokelo sa placental mme e batla e na le metabolism e felletseng, e etsa li-metabolites tse peli tse sa sebetseng, tseo e 'ngoe ea tsona e epeloang ka hara bile, e' ngoe ka har'a moroto. Ho felisoa ha halofo ea bophelo ho fapana ho isa ho lihora tse 3 ho isa ho tsa 10-16.

Litaelo tsa ho sebelisa Glibenclamide: mokhoa le litekanyetso

Matlapa a nooa ka molomo metsotso e 20-30 pele ho lihora tse peli ka mor'a lijo.

Ngaka e beha lethal dose ka bonngoe, ho latela boholo ba lefu la tsoekere, lilemo tsa mokuli le boemo ba glycemia.

Tekanyetso e tloaelehileng ea letsatsi le letsatsi e tsoa ho 2,5 ho isa ho 15 mg, ka makhetlo a mangata a tsamaiso. Maemong a sa tloaelehang, lithethefatsi li sebelisoa ka tekanyetso ea feta 15 mg ka letsatsi, sena ha se ame haholo keketseho ea phello ea hypoglycemic.

Tekanyetso ea pele ea bakuli ba tsofetseng ke 1 mg ka letsatsi.

Tekanyetso ea pele ea moriana ha o tsoa ho Biguanides ke 2,5 mg ka letsatsi.

Ho lefella litlolo tsa ts'ebetso ea metabolism ea carbohydrate kamora ho hlakoloa ha li-greatuanides, tekanyo ea glibenclamide, haeba ho hlokahala, e ka eketseha ka 2,5 mg ka matsatsi ohle a 5-6. Phetoho ea kalafo e kopaneng le glibenclamide le biguanides e lokela ho reroa ha ho sa na matšeliso a joalo nakong ea libeke tse 4-6.

Litlamorao

Tšebeliso ea lithethefatsi e ka baka litlamorao tse latelang:

• Ho tloha ts'ebetsong ea "endocrine": hypoglycemia ho fihla ho komisi (lengolo la ngaka le nepahetseng, ho latela kalafo ea litekanyetso le lijo ho fokotsa monyetla oa kholo ea eona),
• Ho tsoa ts'ebetsong ea methapo: ka seoelo - hlooho, ho tsekela, ho tepella, paresis, bofokoli, mathata a ho utloa bohloko,
• Ho tsoa ho tsamaiso ea tšilo ea lijo: ho ikutloa u le boima sebakeng sa epigastric, ho nyekeloa ke pelo, lets'ollo, ka seoelo - cholestasis, mafu a amanang le sebete,
• Ho tsoa ho tsamaiso ea hemopoietic: ka seoelo - hematopoiesis, nts'etsopele ea pancytopenia,
• Boitšoaro bo utloisang bohloko: ho hlohlona, ​​lekhopho la letlalo,
• Boitšoaro ba methapo ea methapo: ka seoelo - photosensitivity.

Lingaka li hlahloba ka glibenclamide

Ho lithethefatsi tse ngata tse laetsoeng kalafo ea lefu la tsoekere, e le molao oa mofuta oa 2-1, bakuli ba hlokometse ho se sebetse hantle hoa Glibenclamide. Ke ile ka tlameha ho hokela lithethefatsi tse ling.

Maikutlo a makatsang ka lithethefatsi. Motho e mong o na le lithethefatsi, motho ha a na sona. Ka bonna, o hloka ho rarolla bothata bona le ngaka ea hau.

Tlhahlobo ea mokuli ea Glibenclamide

Haufinyane tjena Ntate o ile a kula ka lefu la tsoekere la mofuta oa 2. O ile a kena sepetlele ka lebaka la puseletso e phahameng. Ho ne ho e-na le tsoekere ea mali 14. Setsebi sa endocrinologist se laetse ts'ebeliso ea metformin le glibenclamide (ha ke hopole mabitso a khoebo ea lithethefatsi). Ntate o se a qetile khoeli a sebelisa lithethefatsi makhetlo a mararo ka letsatsi. Kae kae kamora beke kamora ho qala ho sebelisa moriana, ke ile ka qala ho tletleba ka ho nyekeloa ke pelo kamehla, empa, ho ea ka eena, sena ha se bohlokoa haholo ha se bapisoa le hore na lithethefatsi li hlile li boloka boemo ba tsoekere ho 6-7 (re lula re sebelisa glucometer), ka hona, ntate oa ka ikutloa a khotsofetse.

Lefu la tsoekere ke lilemo tse 5. Qalong ba ne ba phekoloa ka metformin, empa e ne e sa sebetse hantle haholo - ho ne ho se na litla-morao, empa ho ne ho se na katleho e itseng ho tloaelehileng ho noka tsoekere le eona. Mme sena le ha e le 'nete ke hlahisitse lethal dose habeli. Ebe lilemo tse 2 tse fetileng ke ile ka fuoa glibenclamide, ka e kenyelletsa ho metformin, mme ho tloha ka nako eo lintho li fetohile tse ntle. Ha ho na litla-morao, empa ba ikutloa ba le betere 'me tsoekere hangata e ka tlase ho 7.

Ha se khale haholo, ke tšoeroe ke lefu lena, hoo e ka bang lilemo tse 3-4, ka phoso ka tlhahlobo ea bongaka, ke ne ke sa nahane hore nka ba le lefu la tsoekere. Hona joale ke moeti oa kamehla toropong ea Essentuki le lits'ebetso tsa bongaka. Empa ke boetse ke nka Glibenclamide, ka tsela eo, moriana ona o neng o laetsoe mona toropong ena, ba re o sebetsa hantle haholo mme o tla nthusa. Ke ne ke tloaetse ho sebelisa lithethefatsi tse ling tse fokotsang tsoekere ea mali ka mokhoa o hlakileng. Qalong, ke ile ka ba le litla-morao ka mokhoa oa ho nyekeloa le lets'ollo, empa kamora ho sebelisoa nako e telele, ba qala ho nyamela, ho bonahala, ba tloaela meriana. Empa ka holim'a tsohle, boemo ba tsoekere bo fokotseha haholo ha o sebelisa moriana o neng o tlalehiloe ke glucometer le bophelo bo botle letsatsi lohle.

Ke qetile lilemo tse fetang 15 ke kula le lefu la tsoekere. Ke lekile lithethefatsi tse fapaneng tse theolelang tsoekere, empa Glibenclamide e ntse e le eona e loketseng haholo. Litla-morao tsa mofuta oa ho nyekeloa le pelo le ho hloka takatso ea lijo li ne li le libeke tsa pele, joale tsohle li ile tsa sebetsa. E fokotsa tsoekere hantle ka ho eketseha 'me e u lumella ho e boloka e le tloaelehileng. Tšitiso feela - o lokela ho lekanya tsoekere khafetsa. Empa ho nna e se e le tloaelo.

Tlhaloso e khutšoane

Glibenclamide e theolelang tsoekere ka sebopeho sa eona sa lik'hemik'hale ke ea moloko oa 2 oa menyetla ea sulfonylurea. Ka "fokotseho" ea meriana eohle ea lithethefatsi (le ts'ebelisong ea bongaka e ntse e sebelisoa ho tloha ka 1969), ho ts'epahala ha eona le tsebo li ntse li tsoela pele ho fihlela kajeno. Eseng feela ho ba kae kae ka mor'a matloana, empa ho ba e 'ngoe ea kalafo tse tsebahalang haholo tsa lefu la tsoekere la mofuta oa 2. Litekong tsa laboratori le tsa bongaka, glibenclamide e ntse e le eona tekanyetso ea ho hlahloba katleho ea lintho tse ncha tse sebetsang tsa meriana le mekhoa ea kalafo ea antidiabetes, ha e ntse e bonts'a thepa e ncha e molemo. Mochine oa ts'ebetso ea hypoglycemic ea glibenclamide, hammoho le lithethefatsi tse ling tsa sehlopha sena, li ithutoe ka tsela e qaqileng haholo e arotsoeng limolek'hule: sethethefatsi se thibela menyetla ea potasiamo ea lisele tsa "pancreatic", tseo ka bo tsona li kenyang ts'ebetso ea "calcium" e ka seleng, eo ka nako e 'ngoe e bakang tšenyo ea likhakanyo tse nang le insulin le ho tsoa ha mali ho ea maling le mokelikeli oa metsi o tsoang ka bongata. Har'a lintho tsohle tse tsoang ho sulfonylurea, glibenclamide e fuoa tumellano e tsejoang haholo bakeng sa li-receptor tse lumellanang liseleng tsa β-cell le phello e matla ea hypoglycemic har'a tsohle tse tsoang sulfonylurea. Ho tsoa ha insulin ke eona ntho e kholo le ho feta, e leng moriana o moholo o amohelehang oa moriana.Lithethefatsi tsohle tsa sehlopha sena le tsona li na le litlamorao tse tlisoang ke pancreatic, li etsa hore lisele tsa maoto a marang-rang li amehe haholo ka insulin le ho ntlafatsa tsoekere ea glucose ka adipose le mesifa ea mesifa.

Boemo bona bo thusa ho eketsoa ha tsoekere ke lisele tse ling (bala: ho theola glycemia).

Kahoo, glibenclamide, ho latela lintlha tse 'maloa, e lula e le tlholisano. Pele ho tsohle, ke katleho e bonahatsoang ke ts'ebeliso ea nako e telele ea ts'ebeliso. Moriba o thibela litlamorao tse khutsitseng tsa lefu la tsoekere, ho kenyelletsa le myocardial infarction le mathata a microvascular. Glibenclamide e kopantsoe ka katleho le lithethefatsi tse ling, ho etsa mohlala, metformin, 'me haeba matšeliso a mafu a sa fihlelloe, litholoana tse ntle li ka fumaneha ka motsoako oa makhetlo a mararo oa metformin + glibenclamide + glitazone. Glibenclamide e sebelisoa ka katleho ho bakuli ba tsofetseng ba nang le "sehlopha sa lipalesa" tsa maloetse a kopaneng. 'Me ntho ea bohlokoa ke efe (le bakeng sa batho ba bangata ba amanang le rona - ntho ea bohlokoa ka ho fetisisa), sethethefatsi se fumaneha ho latela maikutlo a moruo. E theko e tlase ho feta "balekane" ba eona ba bangata ba ntoa ea ntoeng khahlanong le lefu la tsoekere.

Ha o nka glibenclamide, ho hlokahala hore ho hlahlojoe ka hloko boemo ba tsoekere ka lebaka la menyetla e ka bang teng ea ho fetoha ha hypoglycemic. Haeba hypoglycemia e "koahetse" mokuli ea sebelisitseng moriana, ho hlokahala hore hang-hang a netefatse hore tsoekere e kena 'meleng oa hae (ka molomo kapa ka ente, ho latela boemo ba hae ba letsoalo). Ntle le moo, boloka lijo tse nang le lik'habohaedreite tse potlakileng li le teng ka linako tsohle.

Thutela-litso

Moemeli oa hypoglycemic ea molomo, e fumanoang molokong oa bobeli. E hlohlelletsa secretion ea "insulin" ke "lisele" tsa manyeme, e eketsa ho tsoa ha insulin. E etsa haholoholo nakong ea mohato oa bobeli oa insulin. E eketsa kutloisiso ea lisele tsa pherekano ho insulin le tekanyo ea ho tlama ha eona ho fihlella lisele. E na le phello ea hypolipidemic, e fokotsa mali a mali a "thrombogenic".

Tšebelisano ea lithethefatsi

Lithethefatsi tsa antimycotic tsa systemic action, ethionamide, fluoroquinolones, MAO le ACE inhibitors, H2-blockers, NSAIDs, lithethefatsi tsa tetracycline, paracetamol, insulin, li-anabolic steroid drug, cyclophosphamide, β-adrenergic blockers, clofibrate, reserpilamin, prober allopurinol, paracetamol, hammoho le chloramphenicol li ka eketsa ho teba ha hypoglycemia.

Li-COC, barbiturates, glucagon, saluretics, litokisetso tse thehiloeng ho letsoai la lithium, diazoxide, li-nicotinic acid derivatives, phenothiazines, hammoho le lithethefatsi tsa adrenomimetic li fokotsa phello ea hypoglycemic ea glibenclamide.

Mefuta e reng acidine ea moroto e eketsa katleho ea moriana.

Rifampicin e khothalletsa ho inactivation ea ntho e sebetsang le ho fokotsa phello ea eona ea kalafo.

Tekanyetso le tsamaiso

Tekanyetso e khethoa ka bonngoe. Ka hare, metsotso e 20-30 pele o ja, ho nwa metsi a mangata. Motsoako oa pele ke 2,5 mg / ka letsatsi. Haeba ho hlokahala, lethalinyana le eketseha butle ka 2,5 mg ka beke ho fumana matšeliso bakeng sa metabolism ea carbohydrate. Sekhahla sa tlhokomelo ea letsatsi le letsatsi ke 5-10 mg, se phahameng ka ho fetisisa ke 15 mg. Bakeng sa bakuli ba tsofetseng, tekanyetso ea pele ke 1 mg / letsatsi. Khafetsa ea tsamaiso ke makhetlo a 1-3 ka letsatsi.

Polelo ea lihlopha tsa nosological

Litheko makaleng a litlama a litsobotsi tsa meriana Moscow

Tlohela maikutlo a hau

Lenaneo la Hona Joale la Litaba tsa Tlhokahalo, ‰

Lithethefatsi tse ngolisitsoeng ka bohlokoa le tse hlokahalang

Setifikeiti sa ho ngolisa sa Glibenclamide

• LP-003742

• LP-000933

• FS-000940

• LS-002499

• P N014959 / 01-2003

• LSR-008753/09

• LS-000992

• LS-002056

• LS-001139

• P N002907 / 01

• P N001630 / 01-2002

• P N013959 / 01-2002

• P N012149 / 01-2000

• P N012093 / 01-2000

• P N011705 / 01-2000

• P N011400 / 01-1999

• S-8-242 N011172

• 010027

• 95/370/3

• 82/374/1

Webosaete ea semmuso ea k'hamphani RLS ®. Encyclopedia ea mantlha ea lithethefatsi le thepa ea bongaka ea semmuso ea Marang-rang ea Russia. Lenane la lithethefatsi Rlsnet.ru le fa basebelisi monyetla oa ho fumana litaelo, litheko le litlhaloso tsa lithethefatsi, tlatsetso ea lijo, lisebelisoa tsa bongaka, lisebelisoa tsa bongaka le lihlahisoa tse ling. Tataiso ea meriana e kenyelletsa tlhahisoleseling mabapi le sebopeho le mofuta oa tokollo, ts'ebetso ea pharmacological, matšoao a ts'ebeliso, contraindication, litla-morao, ho sebelisana ha lithethefatsi, mokhoa oa ts'ebeliso ea lithethefatsi, lik'hamphani tsa meriana. Sesebelisoa sa lithethefatsi se na le litheko tsa meriana le lihlahisoa tsa meriana ho la Moscow le metseng e meng ea Russia.

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Lintho tse ling tse ngata tse khahlang

Litokelo tsohle li sirelelitsoe.

Ts'ebeliso ea thepa ea khoebo ha e lumelloe.

Tlhahisoleseling ena e etselitsoe litsebi tsa bongaka.

Ho sebelisana le lithethefatsi

Ts'ebeliso e ts'oanang ea sulfonamides tse sebetsanang le nako e telele, li-beta-blockers, allopurinol, li-anabolic agents, cimetidine, cyclophosphamide, clofibrate, isobarin, monoamine oxidase inhibitors (MAOs), salicylates, tetracyclines, le chloramphenicol e ka ntlafatsa phello ea lithethefatsi.

Glibenclamide e kanna ea fokotseha mme kotsi ea ho ba le hyperglycemia ho bakuli ka nako e ts'oanang e nka chlorpromazine, barbiturates, diazoxide, phenothiazines, phenytoin, lithethefatsi tsa "acetazolamide", glucocorticoids, glucagon, li-methati tsa methapo ea kutlo, li-salateti tsa molomo. , lihormone tsa qoqotho, litekanyetso tse phahameng tsa laxatives.

Li-analogu tsa Glibenclamide ke: Glibeks, Glibamid, Gilemal, Glidanil, Betanaz, Antibet, Manin, Maninil, Maniglide.

Matšoao a ho khethoa

Mofuta oa bobeli oa lefu la tsoekere ke lefu le tsoelang pele le hlokang kalafo. Le maemong a taolo e ntle ea glycemic, ts'ebetso ea lisele tsa beta butle-butle e mpefala ho bakuli le tlhahiso ea insulin ho tsona ea fokotseha. Ka tsoekere e phahameng kamehla, mekhoa ea timetso ea sele e potlakisa. Liphetoho tsa pele ho secretion ea insulin li ka fumanoa ka nako ea tlhahlobo ea mafu. Ho bakuli ba bang, ha li ame boemo ba tsoekere haholo, mme ho lefella lefu la tsoekere, phepo e nepahetseng feela, metformin le thuto ea 'mele li lekane.

Litsebi tsa lefu la tsoekere, tseo ho lona lisele tse phetseng hantle tsa beta li sa khone ho itšebeletsa le ho sebeletsa baena ba shoeleng, ba tlameha ho fana ka lingoloa tsa sephiri. Li tsosa motsoako oa insulin, o etsa hore lisele li sebetse ka matla le ho feta.

Ha glibenclamide e laetsoe:

1. Setlhare sena se nkoa e le e 'ngoe ea li-secaggue tse matla ka ho fetisisa, ka hona li bontšoa ho bakuli ba nang le lefu la tsoekere ba nang le motsoako o fokolang oa insulin ea bona, joalo ka bopaki ba glycemia e phahameng haholo nakong ea tlhahlobo. Ka mellitus e nang le tsoekere e ntlafalitsoeng, ntlafatso ha e etsahale hanghang, tsoekere e fokotseha hofihlella ka nako ea libeke tse peli. Litsebi tsa lefu la tsoekere le hyperglycemia e nyane ha li fane ka litlhare hanghang kamora ho fumanoa ke lefu la tsoekere.
2. Glibenclamide e bontšoa bakeng sa matlafatso ea kalafo ho kenyelletsa le li-agents tse ling. Ke khale ho netefalitsoe hore lithethefatsi tse 'maloa tse fokotsang tsoekere tse amang lisosa tsa hyperglycemia tse tsoang mahlakoreng a fapaneng li sebetsa haholo ho feta e le' ngoe. Ho ntlafatsa taolo ea metabolic, glibenclamide e ka kopanngoa le insulin le matlapa afe kapa afe a theolelang tsoekere, ntle le a PSM le letsopa.

Ha u fana ka litlhare, ho lokela ho hopoloa hore e etsa hore lisele tsa beta li sebetse ka matla a maholo. Ho latela lipatlisiso, ho hlohlelletsa ho joalo ho lebisa ho fokotseng nako ea bona ea bophelo. Kaha glibenclamide ke eona e matla sehlopheng sa eona, phello ena e sa rateheng e phatlalatsoa bakeng sa eona ho feta ho PSM ea sejoale-joale. Haeba lefu la tsoekere le batla ho boloka motsoako oa insulin ka nako e telele kamoo ho ka khonehang, kalafo e nang le glibenclamide e lokela ho chechisoa ho fihlela lithethefatsi tse fokolang li khaotsa ho laola lefu la tsoekere.

Glibenclamide e sebetsa joang

Mochini oa ts'ebetso oa glibenclamide o utloisisoa hantle mme o hlalositsoe ka botlalo ka litaelo tsa moriana. Ntho ena e thibela likonopo tsa KatiF tse kahara membrane ea beta-cell, e lebisang ho feliseng ha potasiamo liseleng, e fokolisa polarization ea membrane le ho kenella ka hare ho calcium ion. Keketseho ea khoholeho ea calcium ka seleng e susumetsa ts'ebetso ea ho ntšoa ha insulin ho eona ho tsoa mokelikeling oa "metso", ebe o kena maling. Glucose e fokotsehile ka lebaka la matla a insulin ea ho e tsamaisa ho tsoa methapong ea mali ho isa lithong. Glibenclamide e mafolofolo ho feta tse ling tsa PSM e tlamellang ho beta-cell receptors, ka hona e na le phello e ntle ea ho theola tsoekere.

Matla a sethethefatsi a eketseha ka tekanyetso e ntseng e eketseha. Tšusumetso ea glibenclamide ha e ea itšetleha ka glycemia, sethethefatsi se sebetsa ka bongata ba glucose mme se na le e lekaneng, kahoo ha u e nka, u lokela ho ba hlokolosi ka hohle kamoo ho ka khonehang mme u lekanye tsoekere ha matšoao leha e le afe a tšoanang le hypoglycemic a hlaha.

Ntle le hypoglycemic e ka sehloohong, phello e eketsehileng ea phello ke tšobotsi ea PSM eohle. Ho latela litaelo, glibenclamide e fokotsa ho hanyetsa ha insulin ea lisele tsa mesifa le mafura, e leng ho eketsang phokotso e eketsehileng ea tsoekere.

Liphello tsa pelo ea lithethefatsi li ile tsa ithutoa ka thoko. Ho ile ha fumaneha hore glibenclamide e khona ho thibela liteishene tsa KatiF eseng feela ka lisele tsa beta, empa le lisele tsa pelo - cardiomyocyte. Ka mohopolo, ketso e joalo e ka mpefatsa litlamorao tsa lefu la pelo ho batho ba nang le lefu la tsoekere. Litekong tsa kliniki, litla-morao tsena ha li e-so tiisoe. Ho feta moo, phello e phatlalalitsoeng ea antiarrhythmic e fumanoe ho glibenclamide, e fokotsang lefu la batho nakong e mpe ea ischemia. Ho ea ka lingaka, tse ngata tsa tsona li tšaba ho fana ka moriana o bitsoang Glibenclamide bakeng sa lefu leha e le lefe le fumanoeng la pelo, leha ho le joalo ka tlhaiso-leseling.

Litokisetso tsa Glibenclamide

Boholo ba batho ba lefu la tsoekere ba tloaelane le glibenclamide ke lithethefatsi Maninil, se hlahisoang Jeremane ke Berlin-Chemie. Moriana ona ke oa mantlha, 'me ho bile le karolo ea ona e makatsang ea lithuto tse ithutileng ka katleho le polokeho ea glibenclamide. Maninil o na le likhetho tse 3 tsa litekanyetso. Ho matlapa a 1.75 le 3.5 mg, ntho e sebetsang e ka sebopeho se khethehileng sa micron, se lumellang ho fokotsa glycemia ka lethal dose le tlase la moriana. 5 mg maninyl e na le li-classical glibenclamide.

Li-Analogs tsa Russia ke:

• Statiglyn ho tsoa Pharmasintez-Tyumen le Glibenclamide ho tsoa k'hamphaning ea Ozone (atoll e ngolisitsoeng ke ea Atoll LLC). Lithethefatsi tsena li na le litekanyetso tse tšoanang, empa baetsi ha ba re ho ba teng ha glibenclamide ea micronised ho eng kapa eng eo u ka e khethang.
• Matlapa a Glibenclamide a entsoeng ke Moskhimpharmpreparaty, Pharmstandard-Leksredstva, Biosynthesis, Valenta Pharmaceuticals ba na le litekanyetso tse le 'ngoe tsa 5 mg. Li ka aroloa ho fumana tekanyetso ea halofo ea 2,5 mg.

Ho bohlokoa ho hlokomela hore ke li-analogue tsa maemo a lapeng feela, kaha likhoebo li reka glibenclamide kantle ho naha, haholo India. Phapang e le 'ngoe feela ke Statiglin, e ngolisitsoeng ka 2017. Glibenclamide bakeng sa eona e hlahisoa Russia khoebong ea BratskKhimSintez.

Li-analogues tsohle tsa Maninil li lekoa bakeng sa bioequivalence mme li na le sebopeho se tšoanang. Tlhahlobo ea mokuli e bontša hore meriana ena e sebetsa ka mokhoa o ts'oanang, empa batho ba nang le lefu la tsoekere ba khetha ho reka sethethefatsi sa pele, ka lebaka la botumo ba sona bo boholo le theko e tlase.

Ha re nahana ka litlhahlobo, ho kopantsoe ha glibenclamide le metformin le hona ho tsebahala haholo. Lintho tsena ka bobeli ke karolo ea lithethefatsi tse likarolo li peli Glucovans, Glimecomb, Gluconorm. Metglib, Glibomet le ba bang.

Re amoheloa le mang?

Taelo e hlahisa thibelo ea ho nka matlapa a Glibenclamide maemong a latelang:

• haeba sethethefatsi kapa litšoantšetso tsa hae li ne li e-na le allergy,
• ha lefu la tsoekere ha le na lisele tsa beta (mofuta oa 1 lefu la tsoekere, resection ea pancreatic),
• boemong ba ho bola ho matla ha lefu la tsoekere la mellitus le ketoacidosis kapa kotsing e kholo ea ho buseletsoa ka lebaka la likotsi tse mpe le mafu,
• e na le bothata bo matla ba ho renal le hepatic,
• tabeng ea ho hloka mamellano ea lactose, e fumanoang moriring joalo ka ntho e thusang.
• nakong ea kemolo, ho nyeka,
• baneng ba lefu la tsoekere.

Ka tlhokomeliso e fetelletseng, ho hlokahala ho etsa kalafo bakeng sa mathata a lihormone, joala, mafu a tšilo ea lijo, botsofaling, ka mocheso o phahameng.

Li-analog le likheo tsa Glibenclamide

Li-analogues tse haufi haholo tsa glibenclamide ke lintho tse ling tse tsoang ho sulfonylureas. Hona joale, glyclazide, glimepiride e sebelisoa haholo, hangata glycidone.

Libone tsa theko e phahameng ka ho fetisisa tsa "glibenclamide"

Li-gliptins, tse thusang hape ho theha motsoako oa insulin, li theko e phahameng haholo tsa glibenclamide analogues. Glyptins ke karolo ea Januvii, Ongliza, Xelevia, Galvus, Trazhenty, litšenyehelo tsa bona tsa kalafo li bitsa bonyane li-ruble tse 1,500. ka khoeli. Lithethefatsi tsena ha li bake hypoglycemia, ha li kenye letsoho ho feliseng lisele tsa beta, empa u se ke ua fokotsa tsoekere kapele joalo ka glibenclamide. Ho latela maikutlo, li-glyptins li fana ka litholoana tse ntle tse neng li se na glycemia e phahameng haholo.

Theko ea litlhare tsa meriana

Maninil e nang le glibenclamide e nang le micronised e bitsa li-ruble tse 130-160. ka pakete e 'ngoe le matlapa a 120. Maninil 5 mg e tla ba theko e tlase, theko ea pakete e ka ba li-ruble tse 120. Litsenyehelo tsa li-analogues tsa lapeng le tsona li tlase haholo: ho tloha li-ruble tse 26. bakeng sa matlapa a 50 kapa li-ruble tse 92. matlapa a 120. Ka hona, leha e le tekanyo e kholo, theko ea kalafo ha e feta li-ruble tse 100. ka khoeli.

Lithethefatsi Glibenclamide e ka fumaneha mahala sebakeng leha e le sefe sa Russia, haeba mokuli a e-na le lefu la tsoekere, mme o ngolisitsoe le endocrinologist.

Litlhahlobo ho Glibenclamide

Hangata, litlhahlobo tsa Glibenclamide ke lipuisano tsa mekhoa ea kalafo e sebelisoang ho bakuli ba nang le lefu la tsoekere. Boholo ba bakuli ba tlaleha ho nka moriana ona e le monotherapy, leha ho le joalo, batho ba bang ba e fuoa e le karolo ea kalafo e kopaneng, ke hore, hammoho le lithethefatsi tse ling tsa hypoglycemic. Ka linako tse ling bakuli ba na le lipotso ka lebaka la ts'ebetso e feteletseng kapa e sa lekaneng ea Glibenclamide.

Litsebi li lumela hore sepheo sa moriana ona e lokela ho ba motho ka mong, le mofuta oa kalafo o lokela ho khethoa maemong ka mong a lefu lena.Ka hona, ho nka Glibenclamide ho latela litlhahiso tsa ho ba sieo ho thata haholo mme ho ka ba kotsi ho bophelo bo botle. Ho na le lintlha tse ngata tse lokelang ho nahanoa, mohlala, boemo ba tsoekere ea mali ba mokuli maemong a fapaneng. Ke maemong ana feela, ho ka nahanoang hore ho sebelisa moriana ho tla ntlafatsa boiketlo ba mokuli.