Thioctic asiti

Li-antioxidants ke lintho tse thibelang karabelo ea oxidative. Li-radicals tsa mahala tse loantšang mekhoa e mengata ea methapo 'meleng. Ha li lumelle nts'etsopele ea mofets'e, mafu a pelo le methapo. Har'a lintho tse nang le thepa ena ke acidum thiocticum. Taeo ea ts'ebeliso ea thioctic acid (poleloana e fetoletsoe ho tsoa ho Selatine) e re ke ketso e le 'ngoe feela ea liketso tse' maloa.

Kopo

Thioctic kapa lipoic acid ke sesebelisoa se bioactive seo pele se neng se nkuoa e le ntho e kang vithamine. Empa ka mor'a lipatlisiso tse qaqileng, o ile a ba har'a li-vithamine tse bonts'ang thepa ea kalafo. Libukeng tsa bongaka, lebitso la Vitamin N le fumanoa.

E le antioxidant, thioctic acid e tlama li-radicals tsa mahala. Ka phello ea eona 'meleng, e tšoana le livithamini tsa sehlopha sa B. Ntho e bonts'a thepa ea detoxification le hepatoprotective.

Polysaccharide ke mofuta o ka sehloohong oa polokelo ea nama ea khale le ea polokelo. E putlama tlasa ts'usumetso ea li-enzymes ha boemo ba tsoekere bo fokotseha, mohlala, nakong ea ho ikoetlisa ka matla a 'mele. Acid e fokotsa menyetla ea hore lefu la tsoekere le kotsi - ho tsitsinyeha ha ts'ebetso ea tsamaiso ea methapo, pelo le methapo ea mali.

Kamora ho tsamaisa, ntho e kenngoa kahara pampitšana ea ka mpeng. Ts'oarello e kholo e bonoa kamora nako ea metsotso e 25 ho isa ho hora e le ngoe. Sekhahla sa bioavailability se tloha ho 30 ho isa ho 60%. Lipoic acid e epolloa ka sebopeho sa metabolites ka liphio.

Khahlano le Cholesterol le boima ba 'mele

Lipoic acid e fokotsa bongata ba k'holeseterole e kotsi maling, kaha e nka karolo ho metabolism ea mafura 'me ke karolo ea bohlokoa ho eona. Hypocholesterolemic athari e bonahala ha vithamine e lekaneng e kena 'meleng. Setlhare sena se boetse se thibela takatso ea lijo. Sena se thibela boima ba 'mele haholo ebile se tiisa boima ba' mele.

Ka kalafo ea methapo ea methapo

Ka ho boloka tekanyo e hlokahalang ea thioctic acid 'meleng, ho a khonahala ho fokotsa menyetla ea ho ba le methapo ea pelo, ho kenyeletsoa le lichapo le ho otloa ke pelo. Ho bakuli ba nang le tšoaetso e joalo, ntho ena e fokotsa litlamorao tsa lefu lena mme e thibela mathata a kotsi.

Lithethefatsi li potlakisa nako ea ntlafatso, li kenya letsoho ho tsosoloseng mesebetsi ea 'mele ka mor'a ho otloa ke stroke. Maemong ana, tekanyo ea "parresis" (litho tse sa felletseng tsa ho holofala) le ts'ebetso e sa sebetseng ea litho tsa boko li fokotsehile.

Thioctic acid e sebelisetsoa polyneuropathy (lefu la tsoekere, lino tse tahang), chefo, haholoholo, ka letsoai la tšepe tse boima, botoro bo botala. Lithethefatsi li sebetsa ho li-pathologies tsa sebete:

• hepatitis vaerase, hepatitis e sa foleng
• mafura a senyehileng,
• cirrhosis.

Vitamin N e fuoe hyperlipidemia, e fumanoeng e le coronary atherosclerosis, e nonneng haholo.

Contraindication

Thioctic acid ha e sebelisoe kalafo tlasa maemo a latelang:

• hypersensitivity ho lipoic acid kapa metsoako e meng eo e leng karolo ea lithethefatsi, ho lactose,
• mokuli ha aa ka a fihla lilemong tsa 6, ka litekanyetso tsa 600 mg - 18 lilemo.

Ho neuropathy e matla e hlahisoang ke lefu la tsoekere mellitus, thioctonic acid e fanoa kahare ho 300-600 mg. Liente li fanoa ka ente kapa a rotha. Thupelo e nka libeke tse 2-5. Ebe ho ngolloa foromo ea letlapa.

Litekanyetso li beoa ke ngaka, e nahanang ho teba ha lefu le boemo ba mokuli.

Nako e fokolang ea phekolo ke libeke tse 12. Ho latela qeto ea lingaka, thupelo e tsoela pele ho fihlela ba fihlela sephetho se lebelletsoeng.

Litla-morao

Leha lenane la karabelo e mpe e bakoang ke tšebeliso ea lithethefatsi e le khuts'oane haholo, u lokela ho le tseba.

Nakong ea kalafo, maikutlo a joalo a bohloko a etsahala:

• ha a kenella - mathata a ho ja, a bonahatsoang ke ho nyekeloa, ho hlatsa, litulo tse tsamaeang le bohloko ba ka mpeng,
• matšoao a hyperreaction - lekhopho la lefu la hoselese, uritisaria, ho ts'oaroa ha anaphylactic,
• cephalgia
• ho theoha ha sekhahla sa tsoekere ea mali,
• ka tsamaiso e potlakileng ea tsamaiso ea botsoali - ho ts'oaroa kapa ho ts'oaroa ka phefumoloho, khatello e eketsehileng ea maqhubu, diplopia - pherekano e bonahalang moo mahlo a habeli a hlahang mahlong, mesifa ea mokokotlo, ho tsoa mali, joalo ka liplatelete, leqhubu la tsebetso e tsoang ho dermis, lera la mucous le hatelletsoeng.

Likarolo tsa tšebeliso

Lijo li etsa hore ho be thata ho monya moriana. Monyetla oa ho sebelisa thioctic acid nakong ea kemolo ho latela tekanyo ea melemo bakeng sa basali le likotsi tsa ngoana ea e-song ho tsoaloe. Ka kakaretso, litlamorao tsa lithethefatsi ho lesea le sa tsoa emoloa ha le e-so theoe ke FDA.

Ka ho fana ka thioctic acid, ngaka e laola lebese leo feela, haholo-holo ho bakuli ba nang le lefu la tsoekere. Nakong ea phekolo, joala ha bo khetholloe lijong.

Boloka matlapa ka mocheso oa + 25 ° C, o sirelletsang ho pepesetsoa ke khanya ea letsatsi le mongobo. Khetholla phihlello ea bana ntle le tumello ho moriana.

Ho sebelisana le lithethefatsi tse ling

Thioctic acid e sebetsana le meriana e itseng, e ka amang sephetho sa kalafo. Lintho tse latelang li bonoa:

• Moriba o ntlafatsa litheko tsa lithethefatsi tse theolelang tsoekere ka mali ka tsela e ts'oanang o amang insulin. Sena se hloka khetho e hlokolosi ea litekanyetso tsa lihlahisoa tsa hypoglycemic.
• Tharollo ea thioctic acid e fokotsa katleho ea cosplatin, e sebelisetsoang ho phekola li-pathologies tsa mofetše.
• Foromo ea mokelikeli e thibetsoe ho sebelisoa ka nako e le ngoe le tharollo ea ringer, dextrose, lithethefatsi tse sebelisanang le discride le lihlopha tsa SH-.
• Ho matlafatsa thepa e khahlanong le ho ruruha ea glucocorticoids.
• Tai ea Ethyl e fokotsa litlamorao tsa sethethefatsi.

Bongata

Bongata ba ho feta bo hlaha hangata. Sena se bakoa ke taba ea hore asiti e ngata e tsoang lijong e ntšoa ka potlako, ntle le ho ba le nako ea ho lematsa 'mele. Leha ho le joalo ho bakuli ba tšebeliso e telele ea lithethefatsi, tšebeliso ea litekanyetso ka holimo ho se boletsoeng, boemo bo mpefala. Litletlebo tse latelang li hlaha:

• Hyperacidity ea lero la gastric,
• pelo e bohloko
• bohloko bo ka mokoting oa mpa
• hlooho e bohloko.

Litsenyehelo tsa thioctic acid li ipapisitse le moetsi le mofuta oa tokollo ea moriana. Litheko tse latelang lia sebetsa:

• tharollo bakeng sa tsamaiso ea methapo (li-ampoules tse 5, 600 mg) - li-ruble tse 780.,
• tsepamisa mohopolo bakeng sa ho lokisa tharollo (30 mg, 10 ampoules) - 419 rub.,
• matlapa a 12 mg, 50 likhomphutha. - ho tloha ho 31 rub.,
• Matlapa a 25 mg, li-pcs tse 50. - ho tloha ho li-ruble tse 53.,
• Matlapa a 600 mg, li-pcs tse 30. - 702 rub.

Ka marang-rang a litlama, lithethefatsi tse nang le mantlha e sebetsang ea thioctic acid li hlahisoa tlasa mabitso a latelang:

• Tharollo Espa-Lipon (Esparma, Duitsland),
• tharollo ho ampoules Berlition 300 (Berlin-Chemie AG / Menarini, Jeremane),
• Letlapa le koahetsoeng ka lifilimi,
• Litafole tsa Tiogamma (Woerwag Pharma, Jeremane),
• Thioctacid BV (Meda Pharma, Duitsland),
• Matlapa a Tiolipon (Biosynthesis, Russia),
• Li-capsule tsa Oktolipen (Pharmstandard, Russia),
• matlapa, tharollo ho li-ampoules tsa Tielept (Canonpharma, Russia)

Li-analogue tse theko e phahameng kapa tse theko e tlase li khethoa ke ngaka feela.

Batho ba bangata ba bone litlamorao tsa thioctic acid ka bobona. Boikutlo ka sesebelisoa bo fapane. Basebelisi ba bang ba fumana hore e na le thuso, ba bang ba re ha ho na phello.

Thioctic acid e ajoa likhoebong ntle le lengolo la ngaka. Empa ha ba khothaletsoe ho sebelisa lithethefatsi ba le bang, haholo-holo baneng. Haeba ho na le matšoao a tšoanang le a ngaka e laetsoeng, etela ngaka pele ho fumana sesosa sa bothata bona. Mme feela kamora ho hlahlojoa ka botlalo, setsebi se hlahisa Thioctic acid. Litaelo tsa tšebeliso, tse fanoeng mona, li fanoa bakeng sa ho tloaelana le lithethefatsi ka kakaretso.

Vitamin N e boetse e fumanoa lijong, moo ho bolokehileng hore e ka e fumana. Litsebi tsa phepo e khothaletsa ho ja libanana, li-legam, linaoa, lieie, lebese, litlama, mahe. Tekanyetso ea letsatsi le letsatsi ea thioctic acid ho motho e moholo e tsoa ho 25 ho isa ho 50 mg. Ho basali baimana le ba anyang, tlhokahalo ea lona ea eketseha, 'me e fihla ho 75 mg.

Tlhahlobo ea lingaka ka thioctic acid

Setlhare sena sea khahlisa ho latela thepa ea sona e phatlalalitsoeng ea antioxidant. Ke sebelisa peo ea botona ho bakuli ba nang le botona ba botona ba banna ho loants'a khatello ea maikutlo (oxidative), eo litsebi tsa kelello li ntseng li e ela hloko haholo. Tšoaetso ea thioctic acid ke ntho e le 'ngoe - lefu la tsoekere, empa litaelo li bolela ka ho hlaka hore "sena ha se lebaka la ho nyenyefatsa bohlokoa ba thioctic acid ka ts'ebetso ea bongaka."

Ka tšebeliso ea nako e telele, e ka fetola litakatso tsa tatso, ea fokotsa takatso ea lijo, thrombocytopenia ea khonahala.

Nts'etsopele ea lithethefatsi tsa antioxidant ke ea thahasello ea bohlokoa kliniking kalafong ea maloetse a mangata a urogenital sphere.

Neuroprotector ea bokahohleng e nang le thepa ea antioxidant, e sebelisoang khafetsa ke bakuli ba nang le lefu la tsoekere, hammoho le bakuli ba nang le polyneuropathies, e na le mabaka.

Theko e lokela ho ba tlase hanyane.

Ka kakaretso, sethethefatsi se setle se nang le thepa ea antioxidant e boletsoeng. Ke nkhothaletsa tšebeliso ts'ebetsong ea bongaka.

Ke sebelisa kalafo e rarahaneng ea bakuli ba nang le lefu la tsoekere la maoto, mofuta oa neuro-ischemic. Ka tšebeliso ea kamehla fana ka litholoana tse ntle.

Bakuli ba bang ha ba bolelloe ka tlhoko ea kalafo ka moriana ona.

Bakuli ba nang le lefu la tsoekere ba lokela ho fumana mokhoa o fokolang oa phekolo ka moriana ona habeli ka selemo.

Mamello e ntle haholo le phello e potlakileng ha e sebelisoa kahare.

Ntho ha e sa tsitsa, e ea bola kapele ha e le ka ts'usumetso ea khanya, ka hona, ha e sebelisoa ka matla, ho hlokahala hore ho thatela botlolo ea tharollo ka foil.

Lipoic acid (litokisetso tsa thiogamma, thioctacid, berlition, octolipene) e sebelisoa ho thibela le ho phekola mathata a lefu la tsoekere, haholoholo, lefu la tsoekere la polyneuropathy. Ka li-polyneuropathies tse ling (joala, tse nang le chefo) le tsona li fana ka phello e ntle.

Tlhahlobo ea Mamello ho Thioctic Acid

Setlhare sena se laetsoe hore ke fokotse boima ba 'mele, se ile sa mpha litekanyetso tsa 300 mg makhetlo a 3 ka letsatsi, bakeng sa likhoeli tse tharo ha ke sebelisa lithethefatsi sena liphoso tsa ka tsa letlalo li ile tsa nyamela, matsatsi a ka a mahlonoko a ile a ba bonolo ho a mamella, moriri oa ka oa emisa ho theoha, empa boima ba ka bo sa sisinyehe, mme hona ho sa natsoe ho latela CBJU. Ho potlakisa ts'episo ea metabolism, oho, ha hoa ka ha etsahala. Hape, nakong ea ts'ebeliso ea lithethefatsi tsena, moroto o na le monko o itseng, ekaba ammonia, kapa ha ho hlake hore na. Setlhare se soetsehile.

Antioxidant e ntle. E theko e tlase ebile e sebetsa. O ka nka nako e telele ntle le litlamorao tse mpe.

Ke ile ka fuoa thioctic acid mme ka nka 1 pilisi e le 1 ka letsatsi ka likhoeli tse peli. Ke na le tatso e matla ea ka moriana ena mme maikutlo a ka a tatso a ile.

Thioctic acid kapa lebitso le leng ke lipoic acid. Ke nkile lithuto tse peli tsa kalafo ka sethethefatsi sena - thupelo ea pele ea likhoeli tse peli nakong ea selemo, ebe kamora likhoeli tse peli hape thupelo ea likhoeli tse peli. Kamora thupelo ea pele, mamello ea 'mele e ile ea ntlafala ka mokhoa o hlakileng (mohlala, pele ho thupelo eo nka e etsang ka makhetlo a 10 ntle le ho hema ka thata, kamora' nete ea 1 e ne e se e le 20-25). Takatso ea lijo le eona e fokotsehile hanyane ka hanyane, ka lebaka leo, boima ba 'mele ho tloha ho 120 ho isa ho 110 kg ka likhoeli tse 3. Sefahleho se ile sa fifala le ho feta, moriti oa ashen o ile oa nyamela. Ke ne ke nwa matlapa a 2 makhetlo a 4 ka letsatsi ka kemiso nako le nako (ho tloha ka 8 hoseng ka mor'a lihora tse 'ne).

Tlhaloso e khutšoane

Thioctic acid ke moemeli oa metabolic ea laolang metabolism ea lik'habohaedreite le mafura. Litaelo tsa tšebeliso ea lithethefatsi ena li fana ka letšoao le le leng - lefu la tsoekere. Leha ho le joalo, hona ha se lebaka la ho nyenyefatsa bohlokoa ba thioctic acid ka ts'ebetso ea bongaka. Antioxidant ena ea mehleng ea khale e na le bokhoni bo makatsang ba ho tlama li-radicals tsa mahala tse mpe. Thioctic acid e nka karolo ho mafolofolo metabolism, e etsa tšebetso ea coenzyme ka mokokotlo oa liphetoho tsa metabolic tsa lintho tse bolokang lintho tse sirelletsang seleng ho li-radicals tsa mahala. Thioctic acid e matlafatsa ketso ea insulin, e amanang le ts'ebetso ea ts'ebetso ea ts'ebeliso ea tsoekere.

Mafu a bakoang ke mathata a endocrine-metabolic e bile sebakeng sa tlhokomelo e khethehileng ea lingaka ka lilemo tse fetang lekholo. Qetellong ea lilemo tsa bo-80 tsa lekholo la ho qetela la lilemo, mohopolo oa "insulin resistance syndrome" o ile oa qala ho hlahisoa ka meriana, e ileng ea kopanya, ha e le hantle, ho hanyetsa insulin, ho mamella tsoekere e mpe, likhahla tsa cholesterol e "mpe", le litekanyetso tsa "cholesterol e ntle" le boima bo feteletseng le khatello ea mali ea methapo. Sekhahla sa insulin se nang le lebitso se na le "lebitso la metabolic". Ho fapana le hoo, lingaka li hlahisitse metheo ea kalafo ea metabolic e etselitsoeng ho boloka sele kapa ho e nchafatsa, mesebetsi ea eona ea mantlha ea 'mele, e leng boemo ba tšebetso e tloaelehileng ea setho sohle. Phekolo ea Metabolic e kenyelletsa kalafo ea lihormone, ho boloka boemo bo tloaelehileng ba k'holeseterole le ergocalciferol (livithamini tsa sehlopha D), hammoho le kalafo ka li-acid tse bohlokoa tse kenyeletsang alpha lipoic kapa thioctic. Mabapi le sena, ho fosahetse ka ho felletseng ho nahana ka kalafo ea antioxidant ka thioctic acid feela maemong a kalafo ea lefu la tsoekere le lefu la tsoekere.

Joalokaha u bona, setlhare sena le sona ke karolo ea bohlokoa ea kalafo ea metabolic. Pele, thioctic acid e ne e bitsoa "Vitamin N", e bua ka bohlokoa ba eona tsamaisong ea methapo. Leha ho le joalo, ka har'a sebopeho sa eona sa lik'hemik'hale, motsoako ona ha se vithamine. Haeba u sa qhekelle ka "morung" oa biochemical ka ho buoa ka li-dehydrogenase complexes le potoloho ea Krebs, ho lokela ho hlokomeloe thepa e boletsoeng ea antioxidant ea thioctic acid, hammoho le karolo ea eona ho phetatseng li-antioxidants tse ling, mohlala, vithamine E, coenzyme Q10 le glutathione. Ho feta moo: thioctic acid ke eona e sebetsang ka ho fetisisa ho li-antioxidants tsohle, 'me ho a utloisa bohloko ho hlokomela ho se tsotelle ka boleng ba eona ba kalafo le ho fokotseha ho hoholo hoa matšoao bakeng sa ts'ebeliso, tse seng li boletsoe, joalo ka ha ho se ho boletsoe, ho neuropathy ea lefu la tsoekere. Neuropathy ke tšilafalo e mpe ea litho tsa methapo ea kutlo, e lebisang pherekanong ea methapo ea methapo ea methapo, ea pherekano le ea boits'oaro le ho hlaseloa ha litho le litsamaiso tse fapaneng. Manonyeletso ohle a amehile, ho kenyeletsa le li-receptors. Pathogenesis ea neuropathy e lula e amahanngoa le mekhoa e 'meli: matla a metabolism a senyehileng le khatello ea oxidative. Ka lebaka la "tropism" ea morao ho lithane tsa methapo, mosebetsi oa setsebi ha o kenyeletse feela ho fumana matšoao a neuropathy ka kotloloho, empa hape le kalafo ea eona e sebetsang le thioctic acid. Kaha kalafo (ho e-na le hoo, esita le thibelo) ea neuropathy e sebetsa haholo le pele ho matšoao a lefu lena, ho bohlokoa ho qala ho nka thioctic acid kapele kamoo ho ka khonehang.

Thioctic acid e fumaneha matlapeng. Tekanyetso e le 'ngoe ea moriana ke 600 mg. Ka lebaka la synergism ea thioctic acid ho insulin, ka ts'ebeliso e tšoanang ea lithethefatsi tsena tse peli, keketseho ea phello ea hypoglycemic ea li-insulin le li-tablet tsa hypoglycemic e ka bonoa.

Fomu ea tokollo

Matlapa, a koahetsoeng ka filimi ho tloha 'mala o mosehla ho isa ho o moputsoa ka' mala o moputsoa, ​​a chitja, a biconvex, ka bohale ba motheo ke ho tloha ho 'mala o mosehla ho isa ho o mosehla.

Baeti: microcrystalline cellulose 165 mg, lactose monohydrate 60 mg, croscarmellose sodium 24 mg, povidone K-25 21 mg, colloidal silicon dioxide 18 mg, magnesium stearate 12 mg.

Sebopeho sa membrane ea filimi: hypromellose 5 mg, hyprolose 3.55 mg, macrogol-4000 2.1 mg, titanium dioxide 4.25 mg, quinoline e dae 0.1 mg.

Li-pcs tse 10 - Liphutheloana tsa blister (aluminium / PVC) (1) - lipakete tsa karete.
Li-pcs tse 10 - Liphutheloana tsa lithutsoana (aluminium / PVC) (2) - lipakete tsa karete.
Li-pcs tse 10 - Liphutheloana tsa blister (aluminium / PVC) (3) - lipakete tsa karete.
Li-pcs tse 10 - Liphutheloana tsa lithutsoana (aluminium / PVC) (4) - lipakete tsa karete.
Li-pcs tse 10 - Liphutheloana tsa blister (aluminium / PVC) (5) - lipakete tsa karete.
Li-pcs tse 10 - Liphutheloana tsa blister (aluminium / PVC) (10) - lipakete tsa karete.
20 likhomphutha. - Liphutheloana tsa blister (aluminium / PVC) (1) - lipakete tsa karete.
20 likhomphutha. - Liphutheloana tsa blister (aluminium / PVC) (2) - lipakete tsa karete.
20 likhomphutha. - Liphutheloana tsa blister (aluminium / PVC) (3) - lipakete tsa karete.
20 likhomphutha. - Liphutheloana tsa lithutsoana (aluminium / PVC) (4) - lipakete tsa karete.
20 likhomphutha. - Liphutheloana tsa blister (aluminium / PVC) (5) - lipakete tsa karete.
20 likhomphutha. - Liphutheloana tsa blister (aluminium / PVC) (10) - lipakete tsa karete.
Li-pcs tse 30 - Liphutheloana tsa blister (aluminium / PVC) (1) - lipakete tsa karete.
Li-pcs tse 30 - Liphutheloana tsa blister (aluminium / PVC) (2) - lipakete tsa karete.
Li-pcs tse 30 - Liphutheloana tsa blister (aluminium / PVC) (3) - lipakete tsa karete.
Li-pcs tse 30 - Liphutheloana tsa lithutsoana (aluminium / PVC) (4) - lipakete tsa karete.
Li-pcs tse 30 - Liphutheloana tsa blister (aluminium / PVC) (5) - lipakete tsa karete.
Li-pcs tse 30 - Liphutheloana tsa blister (aluminium / PVC) (10) - lipakete tsa karete.
Li-pcs tse 10 - makotikoti a polymer (1) - lipakete tsa karete.
20 likhomphutha. - makotikoti a polymer (1) - lipakete tsa karete.
Li-pcs tse 30 - makotikoti a polymer (1) - lipakete tsa karete.
Li-pcs tse 40. - makotikoti a polymer (1) - lipakete tsa karete.
Li-pcs tse 50. - makotikoti a polymer (1) - lipakete tsa karete.
Li-pcs tse 100 - makotikoti a polymer (1) - lipakete tsa karete.

Ha motho a nooa ka molomo, lethal dose le le leng ke 600 mg.

Ho / in (ho phalla butle kapa ho sesa) ho fanoa ka 300-600 mg / ka letsatsi.

Litlamorao

Kamora ho tsamaisoa ha iv, diplopia, ho tsitsipana, hemorrhage e kenang ka har'a li-membrane tsa mucous le letlalo, ts'ebetso ea mokokotlo o senyehileng e ka khonahala, ka taolo e potlakileng, keketseho ea khatello ea methapo.

Ha o tsamaisoa, matšoao a dyspeptic a khonahala (ho kenyelletsa ho nyekeloa pelo, ho hlatsa, ho opeloa ke pelo).

Ha ho nkoa ka molomo kapa iv, karabelo ea ho kulisa (urticaria, anaphylactic shock), hypoglycemia.