Glemaz: thepa ea lithethefatsi, litekanyetso, litaelo tsa tšebeliso

Glemaz ke setlhare sa litlhare tse tsoang liphateng tsa sulfonylureas tsa moloko oa 3.

Sesebelisoa se sebelisetsoa ho laola maemo a tsoekere ea plasma ka pel'a mokuli ea nang le mofuta o ikemetseng oa insulin ea lefu la tsoekere.

Glemaz e hlahisoa ke indasteri ea litlama ka mokhoa oa matlapa. Matlapa a Glemaz a na le sebopeho se bataletseng sa likonopo, lintlha tse tharo li kenngoa ka holimo.

Sesebelisoa se ka sehloohong sa lithethefatsi ke glimepiride. Ntle le motsoako o ka sehloohong o sebetsang, sebopeho sa meriana se kenyelletsa lintho tse ling tse phethang karolo e thusang.

Meetso e joalo e fumanehang ka sebopeho sa Glemaz ke:

sodium hammart
selulose
magnesium stearate,
Chitin khung,
Dae e ntle e putsoa,
MCC.

Letlapa le le leng le na le 4 mg ea ntho e sebetsang.

Setlhare sena se sebelisoa ho kenella tšebetsong ea monotherapy ka bobeli le karolo ea phekolo e rarahaneng ea kalafo ea mofuta oa 2 lefu la tsoekere.

Pharmacodynamics ea lithethefatsi Glemaz

Glimepiride, eo e leng karolo ea litafole, e tsosa secretion le ho tlosa insulin liseleng tsa beta tsa lithane tsa pancreatic ho kena maling. Ke ka mokhoa ona moo pancreatic phello ea motsoako o sebetsang o bonahatsoang.

Ntle le moo, sethethefatsi se thusa ho ntlafatsa kutloelo-bohloko ea lisele tse itšetlehileng ka insulin - mesifa le mafura ho litlamorao tsa insulin ea lihomone ho tsona. Ka phello ea lithethefatsi liseleng tsa methapo e itšetlehileng ka insulin, phello ea extrapancreatic ea lithethefatsi Glymaz e bonahala.

Taolo ea secretion ea insulin ke lintho tse tsoang ho sulfonylurea e fihlella ka ho thibela likhechana tsa potasiamo tse itšetlehileng ka ATP ka har'a membrane ea lisele tsa pancreatic beta. Ho thibeloa ha liteishene ho lebisa ho depolarization ea lisele, ka lebaka leo, ho buloa ha liteishene tsa calcium.

Keketseho ea khalsiamo ea calcium kahare ho lisele e lebisa ho lokolloeng ha insulin. Ho lokolloa ha insulin ha ho pepesetsoa lisele tsa beta tsa likarolo tsa moriana oa Glymaz ho lebisa ho lokollotsoeng e bonolo le e nyane ea insulin, e fokotsang ho hlaha hoa hypoglycemia 'meleng oa mokuli ea nang le lefu la tsoekere la mofuta oa 2.

Ntho e sebetsang e na le phello e thibelang li-channels tsa potasiamo tse kahara membrane ea cardiomyocyte.

Glimepiride e fana ka keketseho ea ketsahalo ea phospholipase e ikhethang ea glycosylphosphatidylinositol C. Glimepiride e thusa ho thibela sebopeho sa tsoekere ho lisele tsa sebete. Ts'ebetso ena e etsoa ka ho eketsa khatello ea methapo ea mantlha ea fructose 1,6-bisphosphate. Mokelikeli ona o thibela gluconeogeneis.