Matlapa a Ovencor: matšoao a ts'ebeliso, theko le analogues
Liea (li-piritsi) Tekanyetso: 9
Moetsi: Ozone (Russia)
Mefuta ea Tsamaiso:
- Tab. 10 mg, li-pcs tse 20., Theko e tsoang ho li-ruble tse 372
- Tab. 20 mg, li-pcs tse 20., Theko e tsoang ho li-ruble tse 510
Litaelo tsa ho sebelisoa
Setlhare sena se hlahisoa naheng ea Russia, se reretsoeng kalafo ea maloetse a methapo ea pelo le pelo. Ntho e sebetsang ke simvastatin ka bongata ba 10 kapa 20 mg ka ho pepa. E kopantsoe le tlasa lilemo tse 18.
Analogs ea lithethefatsi Ariescor
Analogue e theko e tlase ho li-ruble tse 313.
Moetsi: Vertex (Russia)
Mefuta ea Tsamaiso:
- Letlapa 10 mg, li-pcs tse 15 ,. Theko e tsoang ho li-ruble tse 59
- Letlapa 10 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 62
Litaelo tsa ho sebelisoa
Simvastatin ke lithethefatsi tse theolang lipid tsa Russia ka tlase. E fumaneha ka mokhoa oa litafole 'me e na le ntho e tšoanang e sebetsang ka tekanyetso ea 10 ho isa ho 40 mg. E pakiloe hore e sebelisoe kalafo ea maloetse a pelo le methapo ea pelo.
Analogue e theko e tlaase ho tloha li-ruble tse 173.
Moetsi: Krka (Slovenia)
Mefuta ea Tsamaiso:
- Letlapa 20 mg, 14 likhomphutha., Theko ho tloha li-ruble tse 199
- Letlapa 10 mg, 28 likhomphutha., Theko ho tloha 289 li-ruble
Litaelo tsa ho sebelisoa
Sebopeho se atlehang haholoanyane sa Seslovenia ka mokhoa o ts'oanang oa tokollo le sete sa lintho tse sebetsang. Matšoao a ka sehloohong a sebelisoang: hypercholesterolemia ea mantlha kapa dyslipidemia, ho fokotseha hoa lefu la pelo le moriana ho bakuli ba nang le lipontšo tsa kliniki ea lefu la pelo le lefu la pelo kapa lefu la tsoekere. Ho na le li-contraindication.
Analogue e theko e tlase ho li-ruble tse 265.
Moetsi: Jonathan Richter (Romania)
Mefuta ea Tsamaiso:
- Tab. 10 mg, li-pcs tse 14., Theko e tsoang ho li-ruble tse 107
- Tab. 10 mg, 28 likhomphutha., Theko e tsoang ho li-ruble tse 202
Litaelo tsa ho sebelisoa
Simvastol ke analogue ea tlhahiso ea Seromania. E fumaneha ka har'a lipakete tsa likarete tsa matlapa a 14 le 28. Sesebelisoa se sebetsang sea tšoana mona, kahoo litaelo tsa tšebeliso li na le liphapang tse nyane feela. Pele re qala kalafo, re khothaletsa ka matla ho buisana le ngaka.
Sokolla foromo le sebopeho
Mokhoa oa ho nooa Ovenkor lokolloa - matlapa a koahetsoeng: li-biconvex tse tšoeu, tse pota-potileng ka lebokoseng la 10, 20, 40, 60, 80 le 100, lipakete tse 10, 14, 20, 28, 30, 40, 50 kapa li-pcs tse 100. Lits'ebetsong tsa polymer, ka sekotong sa 1 sek'hafothini.
Letlapa la 1
- ntho e sebetsang: simvastatin - 10 kapa 20 mg,
- likarolo tse thusang: polyethylene glycol-4000, talc, titanium dioxide, oli ea castor, butyl hydroxyanisole, microcrystalline cellulose, ascorbic acid, lactose, citric acid, poone le li-pregelatinized starches, magnesium stearate, hydroxypropyl methylcellulose.
Mofumahali
Setlhare se tsoang sehlopheng sa li-statins, se na le phello e tlase ea lipid, e thibelang HMG-CoA reductase. Sebopeho sa eona se na le se koetsoeng selikalikoe sa lactone, e leng hydrolyzed 'meleng oa motho, ke hore, ke sehlahisoa.
Mokotla oa Lactone li-statins li na le kamano ea enzyme HMG-CoA reductaseka lebaka leo e kopantseng tlholisano ho karolo ea receptor coenzyme Amoo enzyme ena e fihlelang.
Karolo ea molek'hule ea statin e kenella ts'ebetsong ea ho sokoloha hydroxymethylglutarate ka boharenge amanang le sehlahisoa sa motsoako o mahareng oa molek'hule k'holeseterole. Ts'ebetso tsena li baka karabelo tse ngata, ka lebaka leo litaba tsa eona li leng kahare k'holeseterole fokotseha le ho potlakisa cholesterol catabolism LDL. Liphello tse fokotsang lipid tsa lithethefatsi li bakoa ke ho fokotseha ha cholesterol e felletseng ka lebaka la k'holeseterole LDL. Ka nako e ts'oanang, ho fokotseha ho LDL Ho latela lethal dose 'me hoa hlokahala.
Statins ha e ame catabolism le synthesis ea mahala mafura acids, kahoo li ama boemo ba TG ka tsela e sa tobang (bobeli). Ho latela liphuputso, lithethefatsi li hlahisa boemo ba HDL k'holeseterole ho fihla ho 14%. Ntle le litlamorao tse fokotsang lipid, lithethefatsi li na le phello e ntle leboteng la vascular nakong ea khatello ea methapo (letšoao la ponts'o ea tlhahlobo ea pele ea atherosclerosis), li beha maemong a mali a rheological, mme li na le antiproliferative and antioxidant. Phekolo le moriana o tsamaea le ho fokotseha hoa khafetsa ha mathata a pelo le methapo.
Mofumahali
Simvastatin e na le monko o phahameng. Khokahano e kholo ea plasma ea mali kamora ho ts'oaroa e fihlelloa kamora lihora tse 1,3 - 2,4, kamora lihora tse 12 e fokotseha ka 90%. Puisano le liprotheine tsa plasma ke hoo e ka bang 95%.
E na le phello ea karolo ea pele ka sebete: hydrolysis e nang le sebopeho sa li-beta-hydroxyacid tse sebetsang, le li-metabolites tse ling tse sebetsang le tse sa sebetseng le tsona li fumanoe.
Ho felisoa ha halofo ea bophelo ba metabolites e sebetsang ke lihora tse 1,9.
E tšeloa haholo ka mokhoa oa metabolites e nang le makhopho (60%). Ka sebopeho se sa sebetseng, hoo e ka bang 10-15% e epolloa ke liphio.
Matšoao a ho sebelisoa
- hypercholesterolemia: hypercholesterolemia ea mantlha (mofuta oa IIa le IIb) ho bakuli ba nang le menyetla e eketsehang ea ho ba le coronary atherosulinosis maemong a kalafo e sa sebetseng ea phepo e nang le cholesterol e tlase le mehato e meng eo e seng ea lithethefatsi (ho theola boima ba 'mele le ts'ebetso ea' mele), motsoako oa hypercholesterolemia le hypertriglyceridemia, tse sa hlophisoang ka ho khetheha. le ho ikoetlisa
- IHD (lefu la pelo la pelo): ho thibela tšoaetso ea methapo ea pelo, ho fokotsa likotsi tsa lefu la pelo (ho otloa kapa lefu la nakoana la ischemic), lefu, lits'ebetso tsa ntlafatso, hammoho le ho liehisa kholo ea methapo ea methapo ea kutlo.
Contraindication
- lefu la sebete sehlopheng se sebetsang, keketseho e phehellang ea tšebetso ea li-enzyme tsa sebete tse sa tsebeng letho,
- porphyria
- myopathy
- lilemo tse 18
- ho ima le ho nyekeloa,
- ho se mamellehe ha motho karolo efe kapa efe ea lithethefatsi, hammoho le lithethefatsi tse ling tsa statin (HMG-CoA reductase inhibitors) nalaneng.
Setsoalle (Ovenkor o khethoa ka tlasa bolaoli ba tsa bongaka):
- ho nwa haholo
- arterial hypotension, mafu a hlobaetsang a matla a tšoaetsanoang, mathata a matla a endocrine / metabolic, ho se leka-lekane ha metsi, likotsi, ts'ebetso ea ho buuoa (ho kenyeletsa le meno) kapa maemo a mang moo ho ka bang le nts'etsopele ea ho hloleha ho matla ha renal,
- maemo kamora ho fetisoa ha litho nakong ea kalafo ea immunosuppressant (e amanang le kotsi e kholo ea ho se sebetse hantle ha renal le rhabdomyolysis),
- lefu la sethoathoa
- fokotseha / molumo o matlafatsang oa mesifa ea marapo ea tlhaho e sa tsejoeng.
Litaelo tsa ho sebelisa Ovenkor: mokhoa le litekanyetso
Ovencor e nkuoa ka molomo nako e le 1 ka letsatsi mantsiboea, e hlatsuoa ka metsi a mangata. Nako ea ho sebelisa moriana ha ea lokela ho amahanngoa le ho ja.
Pele a qala ts'ebeliso ea Ovenkor, mokuli o fuoa lijo tse tloaelehileng tsa hypocholesterol, tse lokelang ho lateloa nakong eohle ea kalafo.
Ka hypercholesterolemia, tekanyetso ea letsatsi le letsatsi e fapana pakeng tsa 10-80 mg.
Motsoako oa ho qala oa hypercholesterolemia ke 10 mg. Boholo - 80 mg ka letsatsi. Liphetoho (khetho) ea lethal dose li lokela ho etsoa nako le nako ea libeke tse 4. Maemong a mangata, phello e nepahetseng e bonoa ha u sebelisa moriana ka tekanyetso ea letsatsi le letsatsi ea 20 mg.
Ka homozygous hereditary hypercholesterolemia, hangata Ovencor e fanoa ka 40 mg ho lethalinyana le le leng kapa 80 mg ho litekanyetso tse 3 (20 mg hoseng le thapama, 40 mg ka shoalane).
Litekanyetso tse sebetsang tsa Ovenkor bakeng sa lefu la pelo kapa ho ba teng ha kotsi e kholo ea kholo ea lona ke 2040 mg ka letsatsi. Qalong ea phekolo, 20 mg hangata e fanoa, lethal dose le ka eketsoa ka khefu ea libeke tse 4. Ha litaba tsa LDL li le ka tlase ho 75 mg / dl (1.94 mmol / L) mme cholesterol e felletseng e ka tlase ho 140 mg / dl (3,6 mmol / L), tekanyo e ea fokotsoa.
Ka tekanyetso e kholo ea 10 mg, Ovencor o fana ka litlatsetso tse ka tlase ho 30 ml / min ho bakuli ba nang le bothata ba ho hlaphoheloa ha renal (CRF) (clearinine clearance) kapa kalafo e kopaneng le cyclosporine, danazole, gemfibrozil kapa fiber e meng (ntle le fenofibrate), niacin ho lipid tse fokotsang tekanyetso. ho fihlela ho 1000 mg ka letsatsi). Ka tšebeliso e le 'ngoe le amiodarone kapa verapamil, tekanyetso ea letsatsi le letsatsi ea Ovenor ha ea lokela ho feta 20 mg.
Litlamorao
- tsamaiso ea tšilo ea lijo: ho opeloa ke mpa, ho ruruha / lets'ollo, ho ruruha, ho nyekeloa, pancreatitis, hepatitis, ho hlatsa, ts'ebetso e eketsehileng ea li-enzyme tsa sebete, alkaline phosphatase le CPK (creatine phosphokinase),
- litho tsa methapo ea kutlo le tsamaiso ea methapo: hlooho ea hlooho, lefu la astheniki, ho ruruha ha methapo ea pelo, ho tsekela, ho hloka boroko, paresthesia, mesifa ea mokokotlo, tatso e sa foleng, pono e fifalitsoeng,
- ts'ebetso ea immunopathological and allergic reaction: ho chesa ho hoholo, ho choachoasela ka letlalo, ramatiki, vasculitis, angioedema, polymyalgia rheumatism, thrombocytopenia, ho eketsa ESR, lithethefatsi tse khutlisetsang lefu laususus, feberu, uritisaria, photosensitivity, khuts'oafo
- karabelo ea methapo ea mafu: dermatomyositis, rash ea letlalo, alopecia, ho hlohlona,
- Sistimi ea musculoskeletal: bofokoli, myopathy, mesifa crump, myalgia, ka seoelo - rhabdomyolysis,
- maikutlo a mang: palpitations, phokolo ea mali, phokotso ea potency, ho hloleha ha renal haholo.
Bongata
Ho ne ho se na matšoao a itseng a overdose ea Ovenkor (linyeoe tsa ho sebelisa moriana ka tekanyetso ea 450 mg li tsejoa).
Phekolo: mehato e reretsoeng ho fokotsa ho amoheloa ha ntho (ho hlatsa, ho kenya mashala a ts'ebetso), kalafo ea matšoao tlasa taolo ea tšebetso ea renal le hepatic, boemo ba serum ea CPK.
Tabeng ea nts'etsopele ea myopathy ka rhabdomyolysis le ho hloleha ha reisele (a tlolo ea molao ha e khonehe, empa e ka hlaha ka sebopeho se matla), Ovenkor e hlakotsoe hang hang, tsamaiso ea diuretic le sodium bicarbonate e bontšitsoe (ka infravenous infusion). Haeba ho hlokahala, hemodialysis e etsoa.
Rhabdomyolysis e ka baka hyperkalemia, e felisoang ke tsamaiso e kenelletseng ea calcium chloride kapa calcium gluconate, infusion ea tsoekere e kopantsoe le insulin, li-exchanges tsa potasiamo, kapa, maemong a boima, ka hemodialysis.
Litaelo tse khethehileng
Qalong ea kalafo, ho ka bonoa keketseho ea nakoana ea li-enzyme tsa sebete.
Pele o fana ka litlhare le khafetsa nakong e tlang, ho lokela ho etsoa lithuto tsa hepatic. Khafetsa ea ho lekola tšebetso ea li-enzyme tsa sebete: likhoeli tse tharo tsa pele - libeke tse ling le tse ling tse 6, ebe nakong ea selemo sa pele - nako e le ngoe ka likhoeli tse peli, nakong e tlang - nako e le ngoe ka likhoeli tse tšeletseng. Liteko tsa tšebetso ho bona hore na tšebetso ea sebete e sebetsa joang le tsona li etsoa ka tekanyetso e ntseng e eketseha. Haeba tekanyetso e eketseha ho 80 mg ka letsatsi, taolo e lokela ho etsoa hang hang ka likhoeli tse tharo. Ovenkor e felisoa maemong a keketseho e phehellang ea ts'ebetso ea transaminase (makhetlo a 3 ha a bapisoa le boemo ba pele).
Nakong ea kemolo, ho felisoa ha lithethefatsi tse fokotsang lipid ka liphetho tsa kalafo ea nako e telele ea hypercholesterolemia ha e na phello e kholo.
Basali ba lilemo tsa ho ba le bana ba sa sebeliseng lithibela-pelehi ha ba khothalletsoe ho nka Ovenkor.
Ka ts'ebetso ea qoqotho e fokotsehileng (hypothyroidism) kapa boteng ba mafu a itseng a liphio (nephrotic syndrome) le keketseho ea cholesterol, lefu le ipatileng le lokela ho phekoloa pele.
Ho amoheloa ha Ovenkor ho ka lebisa ho nts'etsopele ea myopathy ka ho ba le ketsahalo e ileng ea latela ea rhabdomyolysis le ho hloleha ha renal.
Ha ho e-ba le bohloko bo sa hlalosoang, ho opeloa ke mesifa, ho fokola ha mesifa kapa ho bola, o lokela ho bona ngaka ea hau, haholo haeba mathata ana a tsamaisana le feberu kapa mala. Ho iphumanela / ho lemoha myopathy, kalafo e felisitsoe.
Ho tseba ho hlaha ha myopathy, ho kgothaletswa ho lekanya boleng ba KFK kamehla. Tlhahlobisong e bohloko ea bohloko ka morao ho sternum, ho sebelisa moriana ho lokela ho nahanoa.
Aries e sebetsa joaloka monotherapy mme ha e kopantsoe le li-sequestrants tsa bile.
Ngaka e beha qeto ea hore na nako ea kalafo e joang.
Bokhachane le pelehi
Ho ea ka litaelo, Ovenkor e tšoaetsoe basali nakong ea kemolo / ho beleha.
Ho na le bopaki bo fokolang ba nts'etsopele ea tlhekefetso ho masea ao bo-mme ba nkile moriana. Basali ba lilemo tsa ho ba le bana ba nkang simvastatin ba lokela ho sebelisa mekhoa ea thibelo ea bokhachane. Ha ho ima ho etsahala, Ovenkor e hlakotsoe hang-hang.
Ho sebelisana le lithethefatsi
- erythromycin, immunosuppressants, telithromycin ,cacithromycin, cytostatics, antifungal agents (ketoconazole, itraconazole), nefazodone, fibrate, nicotinic acid ho litekanyetso tse phahameng, li-inhibitors tsa HIV:
- danazol, cyclosporine, gemfibrozil le fiber tse ling (ntle le fenofibrate), niacin, amiodarone, verapamil, diltiazem: kotsi ea myopathy / rhabdomyolysis,
- anticoagulants ea molomo (fenprocoumone, warfarin): kotsi ea ho tsoa mali, ho lekola litekanyetso tsa mali tsa mali pele ho kalafo mme hangata ho lekana nakong ea pele ea kalafo.
- digoxin: keketseho ea boemo ba eona ba plasma,
- colestipol, colestyramine: bioavailability e fokotsehile (o ka nka Ovencor lihora tse 4 kamora ho nka lithethefatsi tsena, ha nts'etsopele ea phello ea tlatsetso e utluoa)
- lero la morara (ho feta 1000 ml ka letsatsi): keketseho e kholo maemong a ts'ebetso ea inhibitory khahlano le HMG-CoA reductase ho plasma ea mali (metsoako e lokela ho qojoa).
Litšoantšiso tsa Ovenkor ke: Simvalimite, Sinkard, Zorstat, Simvastatin, Holvasim, Simgal, Zokor, Simvor, Simlo, Vasilip, Simvastol.
Tlhaloso ea lithethefatsi
Bareki - Moemeli oa hypolipidemic ea tsoang sehlopheng sa li-statins, inhibitor ea HMG-CoA reductase. Ke sehlahisoa sa thekeng hobane e na le selikalikoe se lactone se koehileng ka sebopeho sa eona, ebe se kenella ka mora 'mele.
Sebopeho sa selikalikoe sa statin lactone se tšoana le karolo ea HMG-CoA encheilini. Ho latela molao-motheo oa mohanyetsi oa tlholisano, molek'hule oa "statin" o latela karolo eo ea coenzyme A receptor moo enzyme e fihlelang teng. Karolo e ngoe ea molek'hule ea statin e thibela ho fetoloa ha hydroxymethylglutarate ho mevalonate, e bohareng kahare ho limolek'hule tsa cholesterol. Ho thibela tšebetso ea HMG-CoA reductase ho lebisa ho karabelo e latellanang, ho fella ka ho fokotseha ha litaba tsa k'holeseterole e kenelletseng le keketseho e potlakileng ea ts'ebetso ea li-receptor tsa LDL 'me, ka hona, ho potlakisa catabolism ea LDL cholesterol (Xc).
Phello ea hypolipidemic ea statins e amana le ho fokotseha hoa boemo ba cholesterol e felletseng ka lebaka la cholesterol ea LDL. Ho fokotseha ha LDL ho latela tekanyetso mme ha ho tsamaellane, empa ho hlahella.
Statins ha e ame ts'ebetso ea lipoprotein le hepatic lipases, ha e ame haholo ho qaleha le tšibollo ea mafura acids a mahala, ka hona, phello ea bona ho boemo ba TG ke ea bobeli ebile e sa tobang ka litlamorao tsa bona tse kholo tsa ho theola boemo ba LDL-C. Phokotso e leka-lekaneng ea boemo ba TG nakong ea kalafo e nang le li-statins ho bonahala e amana le polelo ea masala (moo E) li-hepatocytes tse amanang le catabolism ea li-STD, tse etsang 30% TG.
Ho latela lithuto tse laoloang, simvastatin e eketsa boemo ba HDL-C ho 14%.
Ntle le litlamorao tse fokotsang lipid, li-statins li na le phello e ntle ho dysfunction ea endothelial (lets'oao la preclinical la atherosulinosis ea pele), leboteng la vascular, atheroma state, ntlafatsa mali a rheological, a na le antioxidant, antiproliferative thepa. Ho na le bopaki ba hore simvastatin e ntlafatsa ts'ebetso ea endothelial kamora matsatsi a 30 a kalafo.
Tšebeliso ea simvastatin e ne e tsamaisana le ho fokotseha ha khafetsa ha mathata a pelo le pelo, ho sa tsotelehe boemo ba pele ba LDL-C.
Lethathamo la li-analogues
| Fomu ea tokollo (ka tumello) | Theko, rub. |
| Bareki | |
| Matlapa a 20 mg, li-pcs tse 30. | 476 |
| Avestatin | |
| Actalipid | |
| Atherostat | |
| Tab. 30,02 No. 30 (AVVA RUS OJSC / Sti - Med - Sorb OJSC (Russia) | 232 |
| Tb PO 0.02 No. 30 (ABVA RUS OJSC / Sti - Med - Sorb OJSC (Russia) | 232 |
| Vasilip | |
| Tab 10mg N28 Vector (KRKA, dd. Sebaka se secha / pakete. Vector (Russia) | 329.60 |
| Tab 20mg N28 Vector (KRKA, dd. Sebaka se secha / pakete. Vector (Russia) | 458.20 |
| Tab 40mg N28 (KRKA - Russia LLC (Russia) | 628.20 |
| Vero-Simvastatin | |
| Zovatin | |
| Zokor | |
| 10mg No. 28 tab (Merck Sharp le Dome, UK. England) | 176 |
| Zokor Forte | |
| 40mg No. 14 tab (Merck Sharp le Dome, UK. England) | 458 |
| Tab 40mg N14 (Merck Sharp le Dome, UK. (England) | 519.90 |
| Zorstat | |
| SIMVAHEXAL | |
| Tab 20mg N30 (Hexal AG (Jeremane) | 287.10 |
| Tab 10mg N30 (Hexal AG (Jeremane) | 319.10 |
| Tab 40mg N30 (Hexal AG (Jeremane) | 484.70 |
| Simvakard | |
| Tab 20mg N28 (ZENTIVA a.s. Czech Republic (Czech Republic) | 172 |
| Tab 10mg N28 (ZENTIVA a.s. Czech Republic (Czech Republic) | 218.80 |
| 10mg No. 28 tab (Zentiva k.s. (Czech Republic) | 242 |
| Simvacol | |
| Simvalimite | |
| Simvastatin | |
| 10mg No. 30 tab p / pl. (Borisovsky ZMP OJSC (Belarus) | 38.60 |
| 20mg No. 30 tab p / pl.o (Borisovsky ZMP OJSC (Belarus) | 47.50 |
| Tab 10mg N30 Alsi (Alsi Pharma ZAO (Russia) | 53.70 |
| Tab p / pl. About 20mg N30 Alsi (Alsi Pharma ZAO (Russia) | 54.50 |
| 20mg No. 30 tab p / pl.o AVVA RUS (AVVA RUS OJSC (Russia) | 68.30 |
| 10mg No. 30 tab p / pl.o (Ozone LLC (Russia) | 89.10 |
| 20mg No. 30 tab p / pl.o (Ozone LLC (Russia) | 113.80 |
| Tab 20mg N30 (Verteks ZAO (Russia) | 147.60 |
| Tab 10mg N30 (Verteks ZAO (Russia) | 207.30 |
| Tab 20mg N20 (Hemofarm A.D. (Serbia) | 257.30 |
| Simvastatin alkaloid | |
| 10mg No. 28 tab p / pl. (Alkaloid AO (Macedonia) | 59.80 |
| Simvastatin Zentiva | |
| 10mg No. 28 tab (Zentiva k.s. (Czech Republic) | 259.90 |
| 20mg No. 28 tab (Zentiva k.s. (Czech Republic) | 335 |
| 40mg No. 28 tab p / pl. (Zentiva k.s. (Czech Republic) | 498.70 |
| Simvastatin Pfizer | |
| Simvastatin Sanofi | |
| Simvastatin * (simvastatin *) | |
| Simvastatin-ALSI | |
| Simvastatin-SZ | |
| Matlapa a 40 mg, li-pcs tse 30. (Star Star, Russia) | 91 |
| Simvastatin-teva | |
| Simvastatin-ferein | |
| Simvastatin-Chaikafarma | |
| Li-granules tsa Simvastatin | |
| Simvastol | |
| Tab 10mg N28 (Gideon Richter OJSC (Hungary) | 197.10 |
| Simvor | |
| Tab po 40mg No. 30 (Ranbaxi Laboratories Limited (India) | 60.10 |
| Sebaka sa po 20mg N30 (Ranbaxi Laboratories Limited (India) | 282 |
| Simgal | |
| Tab 10mg N28 (Aivex Pharmaceuticals s.r.o. (Czech Republic) | 287 |
| 40mg No. 84 tab (Teva Czech Enterprise s.r.r.o. (Czech Republic) | 304.40 |
| 10mg No. 28 tab (Teva Czech Enterprise s.r.o. (Czech Republic) | 321.50 |
| 20mg No. 28 tab p / pl. (Teva Czech Enterprise s.r.r.o (Czech Republic) | 410 |
| 10mg No. 84 tab. / Pl. (Teva Czech Enterprise s.r.r.o (Czech Republic) | 609.90 |
| 40mg No. 28 tab p / pl. (Teva Czech Enterprise s.r.r.o (Czech Republic) | 678 |
| 20mg No. 84 tab (Teva Czech Enterprise s.r.o. (Czech Republic) | 870 |
| Tab 40mg N84 (Aivex Pharmaceuticals s.r.o. (Czech Republic) | 1505 |
| Simlo | |
| Tab 10mg No. 28 (Ipka Laboratories Limited (India) | 202.90 |
| Tab 20mg N28 (Ipka Laboratories Limited (India) | 293.60 |
| Simplacor | |
| Syncard | |
| Holvasim | |
Moeti e mong o tlalehile letsatsi la ho felloa ke nako
Ovencor o nka nako e kae hore a utloe hore mokuli oa ntlafala?Boholo ba barupeluoa maemong a mangata kamora letsatsi la 1 ba ile ba utloa ntlafatso. Empa sena se kanna sa se tsamaisane le nako eo u tla ntlafala ka eona. Ikopanye le ngaka ea hau hore na u hloka moriana ona ho fihlela neng. Tafole e ka tlase e bonts'a sephetho sa phuputso e entsoeng qalong ea ketso e sebetsang.
| Litho | % | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 letsatsi | 1 | Moeti e mong o ile a tlaleha tumellano ea kopanoKe nako efe e nepahetseng ea ho nka Ovenkor: ka mpeng e se nang letho, pele, ka mor'a lijo kapa?Basebelisi ba webosaete hangata ba tlaleha ho nka moriana ona ka mpeng e se nang letho. Leha ho le joalo, ngaka e ka khothaletsa nako e 'ngoe. Tlaleho e bontša ha bakuli ba bang ba buisanoeng ba sebelisa moriana.
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