Acetylsalicylic acid: litaelo tsa tšebeliso

Acetylsalicylic acid, ha e entsoe, e kenya letsoho ho senya ts'ebetso ea li-prostaglandins, lintho tse kenyang karolo e kholo ntlafatsong ea linaha tsa masiba, lits'ebetso tsa ho ruruha le bohloko.

Khatello ea tlhahiso ea li-prostaglandins e lebisa katolosong ea methapo ea mali, e thusang ho eketsa karohano ea mofufutso, o hlalosang phello ea antipyretic ea lithethefatsi.

Ts'ebeliso ea lithethefatsi e thehiloeng ho acetylsalicylic acid ho kalafo e lebisa ho fokotseheng ha maikutlo a methapo ea methapo, e hlalosang phello e boletsoeng ea analgesic ea sethethefatsi sena. Acetylsalicylic acid e tsoa lisekeng.

Ke eng e thusang acetylsalicylic acid

Matlapa a acetylsalicylic acid a ngoletsoe batho ba baholo ho a phekola le ho a thibela maemo a latelang:

Ts'ebetso ea ho ruruha e matla - ho ruruha ha mokotla oa pelo, ramatiki, ramatiki e nyane, pneumonia le pleurisy e le karolo ea kalafo e rarahaneng, maqeba a ho ruruha a mokotla oa periarticular,
Letšoao la bohloko ba tlhaho e sa tšoaneng - ho opeloa ke hlooho e bohloko, ho opa ha meno, bohloko ba mesifa bo nang le feberu le vaerase, bohloko ba ho ea matsatsing, bohloko ba hlooho, bohloko bo kopaneng,
Maloetse a lesapo la lesapo la mokokotlo a tsamaeang le bohloko bo boholo - osteochondrosis, lumbago,
Keketseho ea mocheso oa 'mele, feberu ka lebaka la ts'oaetso ea ts'oaetso le ho ruruha' meleng.
Thibelo ea nts'etsopele ea myocardial infarction kapa ischemic stroke ha ho potoloha, ho potoloha, ho bola haholo, madi a teteaneng.
Angina pectoris of a unstable nature,
Phello ea mofuta oa thromboembolism, thrombophlebitis,
Bofokoli ba pelo, mitral valve prolapse (ts'ebetso e sa sebetseng),
Pulmonary infarction, pulmonary thromboembolism.

Contraindication

Matlapa a acetylsalicylic acid a na le li-contraindication tse 'maloa tse sebelisoang. Tsena li kenyeletsa:

Hemorrhagic diathesis le vasculitis,
Gastritis ea tlhaho e senyehileng kapa e senyehileng,
Peptic ulcer ea mala le duodenum,
Ho se sebetse hantle ha mali, tloaelo ea ho tsoa mali,
Khaello ea Vitamin K
Exorting Aortic Aneurysm,
Ho senyeha ho matla ha tšebetso ea liphio le sebete,
Hemophilia
Ho se mamellehe ha motho ka mong ho li-salicylates kapa ho haptjoa ke lintho tse ling ho acetylsalicylic acid e teng nalaneng
Khatello ea mali ea methapo, kotsi ea lefu la hemorrhagic.

Acetylsalicylic acid e nka joang?

Matlapa a acetylsalicylic acid ke a tsamaiso ea molomo. Setlhare se khothalletsoa ho nooa qalong ea lijo kapa hang ka mor'a lijo e le ho thibela nts'etsopele ea khoholeho ea mali ka mpeng ea gastric. Matlapa a ka hlatsuoa ka lebese, ka hona phello e khopisang ea acetylsalicylic acid ho li-membrane tsa mucous tsa tšilo ea lijo ha e na ho ba mabifi kapa ho sebelisa metsi a tloaelehileng a alkaline ntle le khase ka bongata bo lekaneng.

Batho ba baholo ba fuoe Letlapa le le leng la 500 mg ea moriana makhetlo a 2 ka letsatsi, ho latela matšoao le bophelo bo botle ka kakaretso. Tekanyo e phahameng ea letsatsi le letsatsi ke 3 g mme e ka se fetisoe! Nako ea kalafo ka moriana ona e khethoa ke ngaka ho latela matšoao, botebo ba ts'ebetso ea ho ruruha le litšobotsi tsa mmele, empa nako ena ha ea lokela ho feta matsatsi a 10-12.

Bakeng sa sepheo sa prophylactic, ho fokotsa kotsi ea ho ba le myocardial infarction le thromboaggregation, batho ba baholo ba ngolloa matlapa a ½ a "aspirin" 1 ka letsatsi. Nako ea kalafo e ka ba likhoeli tse 1-2. Nakong ena, ho hlokahala hore ho be le tšalo-morao ea ho bona setšoantšo sa mali, ho lekola sekhahla sa phallo ea mali le palo ea liplatelete.

Litlamorao

Pele u sebelisa matlapa a acetylsalicylic acid, mokuli o lokela ho buisana le ngaka. Haeba tekanyetso e fetisitsoe kapa o sa laoloe ebile o sebelisoa nako e telele, litlamorao tse latelang li ka hlaha:

Bohloko ba Epigastric, ho nyekeloa, ho hlatsa,
Letšollo
Dizziness le bofokoli
Ho lahleheloa ke takatso ea lijo
Ho senyeha hoa pono,
Ho tsoa mali - mala, mpeng, gingival, gastric,
Phetoho setšoantšong sa bongaka sa mali - ho fokotseha hoa palo ea hemoglobin le liplatelete,
Tlolo ea sebete le liphio,
Nts'etsopele ea ho hloleha ha renal haholo
Bronchospasm, maemong a tebileng, nts'etsopele ea angioedema le anaphylactic makala.

Ts'ebeliso ea moriana nakong ea kemaro le lactation

Litlhare tsa acetylsalicylic acid ha lia lumelloa ho kenella nakong ea pele le ea boraro ea baimana.

Ho ea ka liphuputso, tšebeliso ea matlapa a aspirini ho basali baimana libekeng tse 12 tse qalang e eketsa haholo kotsi ea ho ba le mahlaba ka mpeng, e leng, ho petsoha hoa bokahare bo kaholimo le bofokoli ba pelo.

Ts'ebeliso ea lithethefatsi ho "trimester" ea bobeli li ka khoneha ka tlhokomeliso e fetelletseng mme ha feela phaello e lebelletsoeng ho mme e tla ba e phahame ho feta kotsi e ka hlahang ho lesea. Matlapa a sebelisoa ka tekanyetso e boletsoeng ka mokhoa o hlakileng (e sebetsang hantle) le ka tlasa tlhokomelo e thata ea bongaka. Nakong ea kalafo, mme ea lebelletsoeng o hloka ho etsa tlhahlobo ea mali khafetsa ho lekola palo ea hematocrit le platelet.

Ts'ebeliso ea acetylsalicylic acid ho trimester ea 3 e thibetsoe ka lebaka la kotsi e kholo ea ho koaloa ha thipa ea "aortic" ka popelong. Ntle le moo, sethethefatsi se ka lebisa ho kenella ka har'a hemorrles ea popelo ka popelong mme sa baka kotsi ea ho tsoa madi ho mma ea lebeletseng.

Ts'ebeliso ea matlapa a acetylsalicylic acid nakong ea matsoele e thibetsoe ka lebaka la kotsi e kholo ea ho ba le ho hloleha ha sebete le liphio ho lesea. Ntle le moo, ho kena 'meleng oa lesea le lebese la' m'a, acetylsalicylic acid ho ka lebisa ho tsoa mali ho tebileng ho ngoana. Haeba ho hlokahala ho sebelisa sethethefatsi sena nakong ea ho anyesa, lesea le lokela ho fetisetsoa lijong tsa maiketsetso tse nang le lebese le riteloang.

Ho sebelisana le lithethefatsi tse ling

Ho sebelisoa ka nako e le 'ngoe matlapa a aspirin a nang le lithethefatsi tse ling ho tsoa sehlopheng sa lintho tse sa tsubeng tsa mali (ibuprofen, nuroferon, indomethacin le ba bang) ho eketsa kotsi ea litlamorao tse thathamisitsoeng kaholimo le matšoao a ho feta. Maemong a mang, bakuli ba ne ba tšoaroa ke lefu la ho hlobaela le ho ba le methapo.

Ka tšebeliso e tšoanang ea acetylsalicylic acid le lithethefatsi tse tsoang sehlopheng sa antacid, ho fokotseha hoa phello ea kalafo ea "aspirin" le ho fokotseha ha eona ho kenella maling.

Matlapa a acetylsalicylic acid ha a lumelloe ho nkoa ka nako e le ngoe le li-anticoagulants ka lebaka la keketseho e tšabehang ea menyetla ea ho tsoa mali ka bongata le ho fokola hoa mali.

Ka ts'ebeliso e tšoanang ea acetylsalicylic acid e nang le diuretics, ts'ebetso ea bona ea kalafo e ea fokotseha.

Tšebeliso e tšoanang ea sethethefatsi sena ka ethanol e ka lebisa chefo le ho taoleng 'mele.

Ho boloka le ho tsamaisa maemo

Matlapa a acetylsalicylic acid a abeloa meriana e mengata ntle le lengolo la ngaka. Moriana o lokela ho bolokoa lilemo tse 4 ho tloha ka letsatsi leo tlhahiso e bontšitsoeng ka har'a sephutheloana. Kamora nako ena, matlapa a ke ke a nkuoa ka molomo.

Boloka lintho tse pakiloeng hole le khanya ea letsatsi, kapa bana.

Foromo ea litekanyetso

Matlapa, 500 mg

Letlapa le leng le na le

ntho e sebetsang: acetylsalicylic acid - 500 mg

Baeti: setapole sa litapole, stearic acid, monohydrate ea citric, talc

Matlapa a benyang a "Flat-cylindrical", a tšoeu, a khabisitsoe ebile a sa ngolloa, 'mabole hanyane

Melemo ea pharmacological

Mofumahali

Kamora ho tsamaisoa ka molomo, asiti ea acetylsalicylic e fetoha metabolite ea mantlha - asiti ea salicylic. Ho kenngoa ha li-acetylsalicylic le asiti tse nang le letsoai ka har'a tšilo ea lijo ho etsahala kapele le ka botlalo. Khokahano e phahameng ea plasma e fihlella kamora metsotso e 10-20 (acetylsalicylic acid) kapa metsotso e 45-120 (salicylates e felletseng). Tekanyo ea ho tlama li-acid ka liprotheine tsa plasma e itšetlehile ka mohopolo, e leng 49-70% bakeng sa acetylsalicylic acid le 66-98% bakeng sa salicylic acid. 50% ea tekanyetso e sebelisitsoeng ea moriana e tšeloa metsoako nakong ea karolo ea pele ka har'a sebete.

Setlhare se tšela mothapo o tsoang bokong ba mali, hape se ikemiselitsoe lebeseng la mokokotlo le mokelikeli oa mali.

Li-metabolism tsa acetylsalicylic le salicelic acid ke glycine conjugate ea salicylic acid, acid e boreleli le conjugate ea eona ea glycine. The biotransformation ea salicylates e etsahala haholo-holo ka sebete 'me ho thehoa li-metabolites tse 4 tse ka sehloohong tse fumanoang liseleng tse ngata le moroto. Exretion ea li-salicylates e etsoa haholo ke secretion e sebetsang mefuteng ea liphio ka sebopeho se sa fetoheng (60%) le ka sebopeho sa metabolites. Tekanyo ea ho pepeseha e itšetlehile ka tekanyetso - ha u nka tekanyetso e nyane, halofo ea bophelo ke lihora tse 2-3, mme ka keketseho ea tekanyetso e ka nyolohela ho fihlela lihora tse 15-30. Ho masea a sa tsoa tsoaloa, ho felisoa ha li-salicylate ho lieha haholo ho feta ho batho ba baholo. Tšusumetso e khahlanong le ho ruruha ea lithethefatsi e hlaha kamora matsatsi a 1-2 a tsamaiso (kamora ho theha boemo ba phekolo bo sa khaotseng ba li-salicylates liseleng, e leng hoo e ka bang 150-300 μg / ml), e fihla ka bongata ka tekanyo ea 20-30 mg% mme nako eohle ea ts'ebeliso e sala e le teng.

Pharadodynamics

Acetylsalicylic acid e na le anti-inflammatory, antipyretic, hape le phello ea analgesic.

Kameho e khahlanong le ho ruruha ea acetylsalicylic acid e hlalosoa ke phello ea eona lits'ebetsong tse etsahalang molemong oa ho ruruha: ho fokotseha ha tumello ea capillaries, ho fokotseha ha ts'ebetso ea hyaluronidase, moeli oa phepelo ea matla a ts'ebetso ea ho ruruha ka ho thibela sebopeho sa ATP, jj.

Matla a antipyretic a amahanngoa le tšusumetso litsing tsa hypothalamic tsa thermoregulation.

Phello ea li-analgesic e bakoa ke phello e teng litsi tsa maikutlo a bohloko le bokhoni ba li-salicylates ho fokotsa phello ea algogenic ea bradykinin.

O mong oa mehato e ka sehloohong ea ts'ebetso ea acetylsalicylic acid ke inactivation (khatello ea tšebetso) ea cycloo oxygenase enzyme (enzyme e kenyellelitsoeng ho sebopeho sa li-prostaglandins), ka lebaka leo tšusumetso ea li-prostaglandins e sitoang. Tlolo ea tlhaho ea prostaglandin e lebisa ho tahlehelo ea kutlo ea liphello tsa methapo ea kutlo ho li-kinins le lingaka tse ling tse fokolisang le tse utloisang bohloko (li-transmitter). Ka lebaka la tlolo ea ts'ebetso ea li-prostaglandins, botebo ba ho ruruha le phello ea tsona ea "" phaletiki ea mmele "setsing sa thermoregulation e fokotsehile. Ntle le moo, phello ea li-prostaglandins ho kutlo ea methapo ea kutlo e fokotsehile, e lebisang ho fokotseha ha kutloelo-bohloko ea bona ho ba buisanang le bohloko. E na le ts'ebetso ea antiaggregatory.

Matla a ho loants'oa lithethefatsi ke ho fokotsa matla a liplatelete le lisele tse ling tsa mali ho ikopanya le ho fokotsa menyetla ea thrombosis. Mochine oa ketso ena o tsamaisana le thibelo ea "cycloo oxygenase" ea arachidonic acid metabolism, thibelo ea li-enzyme tsa "thromboxane synthetase" phosphodiesterase, keketseho ea "calcium" e ngata haholo, phokotso ea tekanyo ea "calcium" e ka mpefatsang methapo ea methapo ea methapo ea methapo ea methapo ea methapo. proaggregation e sebetsang haholo (e kenya letsoho ho kopaneng ea liplatelete), keketseho ea khatello ea adenosine ho cr. ova, blockade ea glycoprotein GP IIb / IIIa receptors. Ka lebaka leo, pokello ea liplatelete e thibeloa, ho hanyetsa ha bona ho deformation hoa eketseha, likarolo tsa rheological tsa mali lia ntlafatsoa, thrombosis e hatelloa, microcirculation e tloaelehile. Bohlokoa bo thibelang ho khomarela ha lipolanete tsa mali bo fihlella ka tekanyetso ho fihlela ho 30 mg. E eketsa ts'ebetso ea plasma ea fibrinolytic mme e fokotsa mokokotlo oa lintlha tse amanang le mali tse amanang le vithamine K. Uric acid e tlotsitsoeng e khothalletsoa ka tekanyetso e phahameng, kaha ho ts'oaroa ha eona ka har'a liphokojoe ha ho na bothata.

Matšoao a ho sebelisoa

a hlobaetsang le rheumatic fever, rheumatoid ramatiki, pericarditis, Dressler syndrome, rheumatic chorea

bonolo ho lefu le leka-lekaneng la bohloko (ho kenyeletsa hlooho ea hlooho, migraine, leino le opang, le bohloko ba lefu la masapo a mokokotlo, ramatiki, menalgia, algomenorrhea)

mafu a lesapo la mokokotlo le tsamaeang le bohloko (lumbago, sciatica)

mocheso o eketsehileng oa 'mele bakeng sa sefuba le mafu a mang a tšoaetsanoang le a tšoaetsanoang (ho batho ba baholo le bana ba fetang lilemo tse 15)

Tekanyetso le tsamaiso

Acetylsalicylic asiti e nkuoa ka molomo ka mor'a lijo tse nang le metsi a mangata - metsi, lebese kapa metsi a liminerale.

Ka lefu la mokokotlo le bohloko ho khothalletsoa ho nka 0,25 - 0,5 g / ka letsatsi (1 / 2-1 tab.) makhetlo a 3 - 6 ka letsatsi. Nako e pakeng tsa tekanyetso e lokela ho ba bonyane lihora tse 4. Tekanyetso e le 'ngoe ea boima ba 1 g. Tekanyo e phahameng ea letsatsi le letsatsi ke 3.0 g.

Haeba, ha u ntse u sebelisa moriana oa acetylsalicylic acid matsatsi a 5, lefu la bohloko kapa ka matsatsi a 3 feberu e ntse e tsoela pele, o lokela ho emisa kalafo mme o bone ngaka.

Litlamorao

ho tsekela, tinnitus, tahlehelo ea litsebe

NSAID gastropathy: bohloko ba epigastric, ho otla ha pelo, ho nyekeloa ke pelo, ho hlatsa, ho tsoa mali ho matla pampiring ea tšilo ea lijo

thrombocytopenia, anemia, leukopenia

Reye / Reye syndrome (encephalopathy e tsoelang pele: ho nyekeloa le pelo le ho hlatsa ho sa feleng, ho se khone ho phefumoloha, ho otsela, mokokotlo, sebete se mafura, hyperammonemia, AST, ALT)

karabelo:: laryngeal edema, bronchospasm, urticaria, "aspirin" asthma ea bronchial le "aspirin" triad (eosinophilic rhinitis, receptor ea nasal ea polyposis, hyperplastic sinusitis)

Ka tšebeliso ea nako e telele:

interstitial nephritis, prephalal azotemia e nang le "creatinine" e eketsehileng maling le hypercalcemia, ho hlobaela hoo ke bohloko haholo, lefu la nephrotic

mafu a mali (anemia, agranulocytosis, thrombocytopenic purpura)

matšoao a eketsehang a ho nyekeloa ke pelo, edema

maemo a eketsehang a aminotransferase maling.

Ho sebelisana le lithethefatsi

Ka ts'ebeliso e kopaneng ea acetylsalicylic acid e nang le litokisetso tsa acid ea valproic, cephalosporins kapa anticoagulants, menyetla ea ho tsoa mali e eketseha. Ka tšebeliso e tšoanang ea lithethefatsi le li-NSAID, litlamorao tse ka sehloohong le tse mpe tsa morao li matlafalitsoe.

Ka mokokotlong oa kalafo ka moriana, litla-morao tsa methotrexate li eketsoa (ha ho etsoa tse fetang 15 mg / beke - Acetylsalicylic acid e hanyetsanoe).

Ka tšebeliso e ts'oanang le lithethefatsi tsa molomo tsa hypoglycemic - tse tsoang ho sulfonylurea - ho na le keketseho ea phello ea hypoglycemic.

Ka tšebeliso e tšoanang ka glucocorticosteroids, ts'ebeliso ea joala, menyetla ea ho tsoa mali ka mpeng e eketseha.

Lithethefatsi li nyenyefatsa phello ea spironolactone, furosemide, antihypertgency le anti-gout agents tse khothalletsang tlhahiso ea li-uric acid.

Tsamaiso ea li-antacid nakong ea kalafo le moriana (haholo-holo tekanyetso ea batho ba baholo ba 3.0 g e ka baka ho fokotseha hoa boemo bo phahameng ba salicylate maling.

Litaelo tse khethehileng

Acetylsalicylic acid e eketsa monyetla oa ho tsoa mali le ha o nka tekanyetso e nyane le ka matsatsi a 'maloa ka mor'a ho e nka. Pele u buuoa ka letho, tsebisa ngaka ea hau, ngaka e buoang kapa ngaka ea meno ka ho nka asiti ea acetylsalicylic. Matsatsi a 5-7 pele a buuoa, ho hlokahala hore ho hlakeloe kamohelo (ho fokotsa ho tsoa mali nakong ea ts'ebetso le nakong ea ts'ebetso ea ts'ebetso). Nakong ea kalafo ea nako e telele, ho khothalletsoa ho etsa tlhahlobo ea mali khafetsa le ho hlahloba liente tsa mali a boloi.

Ka kalafo ea anticoagulation ka nako e le 'ngoe le asiti ea acetylsalicylic ka tekanyetso e nyane, uric acid e tlotsoa e fokotsoa, e ka bang sesosa sa gout.

Ts'ebeliso ea bongaka Se ke oa fana ka litlhare tsa acetylsalicylic acid ho bana ba ka tlase ho lilemo tse 15 ba nang le tšoaetso ea phefumoloho e mpe e bakoang ke tšoaetso ea vaerase, le mafu a tsamaeang le hyperthermia ka lebaka la kotsi ea ho ba le lefu la Reye / Ray).

Lintlha tsa phello ea lithethefatsi ho bokhoni ba ho khanna koloi kapa mekhoa e ka bang kotsi

Ha ho na bopaki ba phello e mpe ea tlhokomelo e sebetsang, ts'ebetso ea makoloi le li-reflexes.

Bongata

Cmaiketsetso: ho tsekela, ho ferekanya pono le ho utloa, ho nyekeloa ke pelo, ho hlatsa, ho phefumoloha ho eketsehileng. Hamorao, ho ba le khatello ea maikutlo ho fihlela mokokotlo, ho hloleha ho phefumoloha, ho tsitsisa tekano ea acid-base (ho phefumoloha alkalosis, ebe metabolic acidosis), ho hloleha ho hlobaetsang le pelo (ARF), ho haroha letsoalo. Botaoa bo bolaeang bo ka etsahala ha o nka tekanyetso ea 200 ho isa ho 500 mg / kg.

Phekolo: hlatsa kapa ho hlatsa ka mpeng, fana ka litlatsetso tse entsoeng ka mashala le litlolo tse tlisoang ke lefutso. Phekolo e lokela ho etsoa lefapheng le ikhethang.

Fomu ea ho lokolla le ho paka

Matlapa a 500 mg

Matlapa a 10 a kentsoe ka har'a polasetiki ea polasetiki ea contour.

Lipakete tse 100 tsa contour bezjacheykovy hammoho le palo e lekanang ea litaelo bakeng sa tšebeliso ea bongaka seterekeng mme lipuo tsa Serussia li behiloe ka lebokoseng le tsoang lebokoseng la karete (liphutheloana tsa sehlopha).

Setifikeiti sa ho ingolisa

Marbiopharm OJSC, Russia

Aterese ea mokhatlo e amohelang likopo ho tsoa ho bareki ka boleng ba lihlahisoa (thepa) Rephaboliking ea Kazakhstan

Russian Federation, 424006, Rephabliking ea Mari El, Yoshkar-Ola,

Fono: (8362) 42-03-12, fax: (8362) 45-00-00

Thutela-litso

E thibela cycloo oxygenase (COX-1 le COX-2) mme e thibela tsela e sa fetoheng ea cycloo oxygenase ea arachidonic acid metabolism, e thibela synthesis ea PG (PGA₂PGD₂, PGF_2alphaTS'OLO₁TS'OLO₂ le ba bang) le thromboxane. E fokotsa hyperemia, exudation, capillary permeability, hyaluronidase, e fokotsa phepelo ea matla a ts'ebetso ea ho ruruha ka ho sitisa tlhahiso ea ATP. E ama libaka tsa subcortical tsa thermoregulation le sensitivity ea bohloko. Phokotso ea GHG (haholo-holo PGE₁ ) bohareng ba thermoregulation ho lebisa ho fokotseha ha mocheso oa 'mele ka lebaka la keketseho ea methapo ea mali ea letlalo le mofufutso o eketsehang. Phello ea li-analgesic e bakoa ke phello e teng litsing tsa kutloelo-bohloko ea bohloko, le ts'ebetso e khahlanong le ho ruruha le bokhoni ba li-salicylates ho fokotsa phello ea algogenic ea bradykinin. Thromboxane Phokotso₂ ka liplatelete li lebisa ho khatellong e ke keng ea fetoloa ea kopanetso, e hlapolla methapo ea mali hanyane. Matla a antiplatelet a phehella matsatsi a 7 kamora tekanyetso e le 'ngoe. Liphuputso tse 'maloa tsa kliniki li bontšitse hore thibelo ea bohlokoa ea ho khomarela lipolanete tsa mali e fihlelloa ho tekanyetso ho fihlela ho 30 mg. E eketsa ts'ebetso ea plasma ea fibrinolytic mme e fokotsa mokokotlo oa lintlha tse amanang le ho ruruha ha vitamini (II, VII, IX, X). E hlohlelletsa bokantle ba uric acid, hobane ho ts'oaroa ha eona ka har'a liphokojoe ha re na bothata.

Kamora ho tsamaisoa ka molomo, e kenella ka ho lekaneng. Ka boteng ba membrane ea enteric (e hananang le ketso ea lero la gastric mme ha e lumelle ho kenngoa ha asiti ea acetylsalicylic ka mpeng), e kenella karolong e ka holimo ea mala. Nakong ea ho monya, e felisoa ka mokhoa o tlatselletsang leboteng la mala le ka har'a sebete (deacetylated). Karolo e anngoeng e hydrolyzed kapele haholo ke litheko tse khethehileng, ka hona, T_1/2 asiti ea acetylsalicylic ha e fetise metsotso e 15-20. E potoloha 'meleng (75-90% ka lebaka la albin)' me e ajoa ka har'a linama e le anion ea acid e nang le letsoai. C_max e fumaneha kamora lihora tse ka bang 2. Acetylsalicylic acid ha e tlamehe ho liprotheine tsa plasma. Nakong ea biotransformation, metabolites e thehoa ka har'a sebete e fumanoang liseleng tse ngata le moroto. Exretion ea li-salicylates e etsoa haholo-holo ka secretion e sebetsang ka har'a li-tubules tsa liphio ka mokhoa o sa fetoheng le ka mokhoa oa metabolites. The excretion ea dintho tse sa fetoheng le metabolites li ipapisitse le pH ea moroto (ka alkalization ea moroto, ionization ea li-salicylates li eketseha, makhopho a tsona a botjha a eketseha, 'me boea bo eketseha haholo).

Tšebeliso ea ntho Acetylsalicylic acid

IHD, boteng ba mabaka a 'maloa a kotsi bakeng sa IHD, ischemia e sa utloiseng bohloko, isangia e sa tsitsang, infraction ea myocardial (ho fokotsa kotsi ea infarction ea myocardial e sa khaotseng le lefu kamora lefu la myocardial), ischemia e khutsitseng ea kelello le boits'oaro ba banna, methapo ea pelo ea maiketsetso (thibelo le kalafo ea thromboembolism) , balloon coronary angioplasty le ho beoa hoa setofo (ho fokotsa kotsi ea ho ts'oaroa hape ha kalafo le ho phekoloa ha methapo ea methapo ea mokokotlo), hammoho le liso tse sa sebetseng hantle tsa botaki ly (Kawasaki lefu), aortoarteriit (lefu Takayasu), mitral phunyang kholofalo ea pelo le atrial fibrillation, mitral belofo prolapse (thromboembolism prophylaxis), e iphetang methapo embolism, lefu Dressler e, infarction methapo, a hlobaetsang le thrombophlebitis. Mofoka oa mafu a tšoaetsanoang le a tšoaetsanoang. Letšoao la bohloko ba bofokoli bo boholo le bo bohareng ba tšimoloho e fapaneng, ho kenyelletsa thoracic radicular syndrome, lumbago, migraine, hlooho ea hlooho, neuralgia, leino le opang, myalgia, arthralgia, algomenorrhea. Thutong ea bongaka ea meriana ea mafu a mafu a mafu a marang-rang le allergology, e sebelisoa butle-butle ho theola tekanyetso ea takatso ea "aspirin" ea nako e telele le ho theha mamello e tsitsitseng ho li-NSAIDs ho bakuli ba nang le asthma ea "aspirin" le "aspirin".

Ho ea ka lipontšo, rheumatism, rheumatic chorea, rheumatoid arthritis, myocarditis e tšoaetsanoang, "pericarditis" - hajoale e sebelisoa ka seoelo.

Bokhachane le pelehi

Ts'ebeliso ea litekanyetso tse kholo tsa li-salicylates kahara trimester ea pele ea bokhachane e amahanngoa le khafetsa khafetsa ea bofokoli ba nts'etsopele ea fetal (cleavage ea mahalapa, likotsi tsa pelo). Ka trimester ea bobeli ea boimana, salicylates e ka fuoa feela ho latela tlhahlobo ea kotsi le melemo. Ho khethoa ha li-salicylate ka har'a trimester ea III ea bokhachane ho khahlanong le.

Li-salicylates le li-metabolites tsa tsona ka tekanyo e nyane li fetela lebeseng la matsoele. Ho ja ka mokhoa o sa sebetseng oa li-salicylates nakong ea lebone ho sa tsamaeeng le nts'etsopele ea maikutlo a mabe ka ho ngoana mme ha ho hloke ho felisoa ha letsoele. Leha ho le joalo, ka ts'ebeliso e telele kapa tsamaiso ka tekanyetso e phahameng, ho anyesa ho lokela ho emisoa.

Litaelo tsa ho sebelisa Acetylsalicylic acid, litekanyetso

Matlapa a reretsoe tšebeliso ea molomo - ho kgothaletswa ho nka ka mor'a lijo ka lebese, metsi a tloaelehileng a nang le alkaline.

Litekanyetso tse tloaelehileng tsa acetylsalicylic acid ho latela litaelo tse sebelisoang ho batho ba baholo - ho tloha ho 500 mg ho isa ho 1 g (matlapa a 1-2) ho fihlela makhetlo a 4 ka letsatsi.

Tekanyetso e le 'ngoe e phahameng ke gramu e le' ngoe (matlapa a mabeli).
Tekanyetso e kholo ea letsatsi le letsatsi ke ligrama tse tharo (matlapa a 6)

Bakeng sa ho ntlafatsa likarolo tsa mali tsa rheological tsa mali, hammoho le inhibitor ea adhesion ea platelet, halofo ea letlapa la acetylsalicylic acid ka letsatsi e beoa likhoeli tse 'maloa.

Ka infraction ea myocardial le ho thibela infarction ea bobeli ea myocardial, ho kgothaletswa ho nka 250 mg ka letsatsi.

Ho ferekana ho matla ha ho potoloha ha kokoana-hloko le ho fokola ha qoqotho ho khothaletsa ho nka halofo ea letlapa ka litekanyetso tsa butle-butle tsa lethal dose ho isa litafoleng tse 2 tsa Acetylsalicylic acid ka letsatsi.

Litlamorao

Taeo e hlokomelisa ka monyetla oa ho nts'etsapele litla-morao tse latelang ha u fana ka Acetylsalicylic acid:

bohloko ba epigastric, ho nyekeloa, ho hlatsa,
lets'ollo
ho tsekela le ho fokola
tahlehelo ea takatso ea lijo
ho senyeha ha pono,
ho tsoa mali - mala, mpeng, gingival, gastric,
phetoho setšoantšong sa bongaka sa mali - ho fokotseha hoa palo ea hemoglobin le liplatelete,
mathata a teng ka har'a sebete le liphio,
nts'etsopele ea ho hloleha ha renal haholo,
bronchospasm, maemong a tebileng, nts'etsopele ea angioedema le anaphylactic makala.

Contraindication

Acetylsalicylic acid e hanyetsanoe maemong a latelang:

lefu la ka mpeng,
aspirin triad,
ho mpefala ha bohloko ba ho ruruha le ho ruruha ha lisele tsa tšilo ea lijo,
karabelo ea ts'ebeliso ea acetylsalicylic acid le litlhare tse ling tse thibelang mafu ka mokhoa oa urticaria le rhinitis,
hemorrhagic diathesis,
hemophilia
hypoprothrombinemia,
khatello ea maikutlo ea portal
khatello ea maikutlo, kotsi ea ho tšoaroa ke lefu la hemorrhagic,
arigicm ea maqhubu,
glucose-6-phosphate dehydrogenase ea haelloa,
Khaello ea Vitamin K
renal le ho hloleha ha sebete,
Reye's syndrome.

Hape, lithethefatsi li loants'oa basali ba baimana, nakong ea ho nyekeloa le ka kutloisiso e eketsehileng ea likarolo.

Acetylsalicylic acid ha e sebelisoe ho phekola bana le bacha ba kulang kapa ba hlaphoheloang ke kukuku le ntaramane, kaha ho ka khoneha nts'etsopele ea encephalopathy e matla ea hepatic encephalopathy.

Bongata

Tekanyetso e feteletseng ea acetisalicylic acid e tsamaisana le tekano ea acid-base le botsitso ba electrolyte. Ho nyekeloa ke pelo, ho hlatsa, bohloko sebakeng sa epigastric, kutlo e fokotsehileng ea kutlo le ho utloahala ha mahlo li bonahala.

Menahano e sa lumellaneng, pherekano, ho thothomela, ho otsela, ho felloa ke metsi, karabelo ea alkaline, komisi, metabolic acidosis le tlolo ea metabolism ea carbohydrate le tsona lia khoneha.

Phekolo e thehiloe ho potlakisa ho felisoa ha moriana, hammoho le ho tloaela tekanyetso ea acid-base.

Analogs Acetylsalicylic acid, theko ea meriana

Haeba ho hlokahala, o ka nkela Acetylsalicylic acid ka analogue ea ntho e sebetsang - tsena ke lithethefatsi:

Ha u khetha li-analogues, ho bohlokoa ho utloisisa hore litaelo tsa tšebeliso ea acetylsalicylic acid, theko le litekolo tsa lithethefatsi tse nang le phello e tšoanang ha li sebetse. Ho bohlokoa ho fumana tlhahlobo ea ngaka le ho se etse phetoho e ikemetseng ea lithethefatsi.

Theko ka har'a litlhare tsa Russia: matlapa Acetylsalicylic acid 500mg 10pcs. - ho tloha ho li-ruble tse 4 ho isa ho 9, matlapa a 20 - ho tloha ho li-ruble tse 15 ho isa ho 21, ho latela li-pharmacies tse 592.

Tsoa hole le bana ka mocheso o sa feteng 25 + C. Bophelo ba Shelf ke lilemo tse 4. Rekoa likhoebong tsa meriana ntle le lengolo la ngaka.