Egipentin - tlhaloso ea lithethefatsi, litaelo tsa tšebeliso, litlhahlobo

Tlohela maikutlo a hau

Lenaneo la Hona Joale la Litaba tsa Tlhokahalo, ‰

Setifikeiti sa ho ingolisa EGIPENTIN

• LP-000879

• LP-000684

Webosaete ea semmuso ea k'hamphani RLS ®. Encyclopedia ea mantlha ea lithethefatsi le thepa ea bongaka ea semmuso ea Marang-rang ea Russia. Lenane la lithethefatsi Rlsnet.ru le fa basebelisi monyetla oa ho fumana litaelo, litheko le litlhaloso tsa lithethefatsi, tlatsetso ea lijo, lisebelisoa tsa bongaka, lisebelisoa tsa bongaka le lihlahisoa tse ling. Tataiso ea meriana e kenyelletsa tlhahisoleseling mabapi le sebopeho le mofuta oa tokollo, ts'ebetso ea meriana Sesebelisoa sa lithethefatsi se na le litheko tsa meriana le lihlahisoa tsa meriana ho la Moscow le metseng e meng ea Russia.

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Lintho tse ling tse ngata tse khahlang

Litokelo tsohle li sirelelitsoe.

Ts'ebeliso ea thepa ea khoebo ha e lumelloe.

Tlhahisoleseling ena e etselitsoe litsebi tsa bongaka.

Tlhaloso ea ts'ebetso ea pharmacological

Lithethefatsi tsa antiepileptic. Sebopeho sa lik'hemik'hale se tšoana le GABA, e sebetsang joaloka mokena-lipakeng oa brake har'a tsamaiso ea methapo e bohareng. Mochine oa ts'ebetso ea gabapentin ho lumeloa hore o fapane le li-anticonvulsants tse ling tse sebetsang ka GABA synapses (ho kenyelletsa le valproate, barbiturates, benzodiazepines, GABA transaminase inhibitors, GABA uptake inhibitors, GABA agonists le GABA drug. Liphuputso tsa in vitro li bonts'itse hore gabapentin e tšoauoa ka ho ba teng ha sebaka se secha se tlamang peptide ho lithane tsa boko ba rat, ho kenyeletsoa hippocampus le cortex ea cerebral, e ka amanang le ts'ebetso ea anticonvulsant ea gabapentin le lihlahisoa tsa eona. Likarolo tse kholo tsa kelello tsa gabapentin ha li tlamele litlhare tse ling tse tloaelehileng le li-receptor tsa neurotransmitter bokong, ho kenyeletsoa le GABAA-, GABAB-, li-benzodiazepine receptors, tse nang le li-receptors tsa NMDA.

Kamora nako, mochine oa ts'ebetso oa gabapentin ha o so thehiloe.

Pharadodynamics

Lithethefatsi tsa antiepileptic. Sebopeho sa lik'hemik'hale se tšoana le GABA, e sebetsang joaloka mokena-lipakeng oa brake har'a tsamaiso ea methapo e bohareng. Mochine oa ts'ebetso ea gabapentin ho lumeloa hore o fapane le li-anticonvulsants tse ling tse sebetsang ka GABA synapses (ho kenyelletsa le valproate, barbiturates, benzodiazepines, GABA transaminase inhibitors, GABA uptake inhibitors, GABA agonists le GABA drug. Liphuputso tsa in vitro li bonts'itse hore gabapentin e tšoauoa ka ho ba teng ha sebaka se secha se tlamang peptide ho lithane tsa boko ba rat, ho kenyeletsoa hippocampus le cortex ea cerebral, e ka amanang le ts'ebetso ea anticonvulsant ea gabapentin le lihlahisoa tsa eona. Likarolo tse kholo tsa kelello tsa gabapentin ha li tlamele litlhare tse ling tse tloaelehileng le li-receptor tsa neurotransmitter bokong, ho kenyeletsoa le GABAA-, GABAB-, li-benzodiazepine receptors, tse nang le li-receptors tsa NMDA.

Kamora nako, mochine oa ts'ebetso oa gabapentin ha o so thehiloe.

Mofumahali

Gabapentin e nkuoa ho tsoa mokeng oa ho silila. Kamora ho kenella Cmax gabapentin ho plasma e fihlelloa kamora lihora tse 2-3. Ho ba le bioavailability ka botlalo ke hoo e ka bang 60%. Kamohelo ka nako e le 'ngoe le lijo (ho kenyeletsoa tse nang le mafura a mangata) ha e ame li-pharmacokinetics tsa gabapentin.

Gabapentin ha e tlamele liprotheine tsa plasma mme e na le Vd ea 57.7 L. Ho bakuli ba nang le lefu la ho akheha, mokokotlo oa mokokotlo oa mokelikeli oa mokokotlo ke 20% ea plasma e lumellanang qetellong ea nako ea dosing.

Gabapentin e pepesetsoa feela ke liphio. Ha ho na matšoao a biotransformation ea gabapentin 'meleng oa motho a fumanoeng. Gabapentin ha e qobelle li-oxidase tse amehang ho metabolism ea lithethefatsi. Ho tlohela ho hlalositsoe hantle ho sebelisoa mohlala. T1 / 2 e ikemetse ka mokhoa o ikemetseng 'me e jare ka lihora tse 5-7.

Ho fana ka tumello ea Gabapentin ho fokotsehile ho batho ba tsofetseng le ho bakuli ba nang le ts'ebetso ea pheko ea mokokotlo. Sekhahla sa khafetsa, plasma le clearance ea gabapentin li lumellana ka kotloloho ho tumello ea creatinine.

Gabapentin e tlosoa plasma ke hemodialysis.

Ho tsepamisa mohopolo oa plasma gabapentin ho bana ho ne ho tšoana le ho batho ba baholo.

Sebelisa nakong ea bokhachane

Hoa etsahala nakong ea kemaro ha feela phello e lebelletsoeng ea kalafo e feta tlokotsi ho lesea (lithuto tse lekaneng le tse laoloang hantle ho basali ba baimana li sa etsoa).

Mokhahlelo oa ketso ea FDA bakeng sa lesea ke C.

Nakong ea kalafo, letsoele le lokela ho emisoa (gabapentin e fetela ka lebeseng la matsoele ha e nooa ka molomo).

Litlamorao

Ho tloha lehlakoreng la ts'ebetso ea methapo e bohareng le tsamaiso ea methapo ea methapo: amnesia, ataxia, pherekano, tšebelisano ea methapo, khatello ea maikutlo, ho tsekela, dysarthria, ho ts'oaroa ke letsoalo, ho ferekana, ho akheha, ho nahana hampe, ho thothomela, ho thothomela, ho akheha, diplopia, hyperkinesia, ho thatafala, ho fokolisa, ho fokolisa, ho fokolisa, ho fokolisa kapa ho fokolisa ho haelloa ke maikutlo, paresthesia, matšoenyeho, lehloeo, ho sitisoa ka molao.

Ho tsoa ho tsamaiso ea tšilo ea lijo: liphetoho mokhoeng oa ho hlohlona meno, lets'ollo, takatso e eketsehileng ea molomo, molomo o omeletseng, ho nyekeloa ke pelo, ho hlatsa, lefu la ho hlohlona, ​​ho nyemeloa, gingivitis, bohloko ba ka mpeng, pancreatitis, liphetoho liphatong tsa tšebetso ea sebete.

Ho tsoa ho sistimi ea hemopoietic: leukopenia, e fokotse palo ea lisele tse tšoeu tsa mali, thrombocytopenic purpura.

Ho tsoa ts'ebetsong ea ho hema: rhinitis, pharyngitis, khohlela, pneumonia.

Ho tsoa ts'ebetsong ea musculoskeletal: myalgia, arthralgia, masapo a masapo.

Ho tsoa ho tsamaiso ea pelo le methapo: methapo ea methapo ea kutlo, lipontšo tsa vasodilation.

Ho tsoa ts'ebetsong ea moroto: ts'oaetso ea ts'ebetso ea moroto, ho ruruha ha urinence.

Litla-morao: Matšoao a ho erythema multiforme, a Stevens-Johnson.

Boitšoaro ba letlalo: Makhopho a letlalo, makhopho, ho hlohlona, ​​lekhopho.

Tse ling: bohloko ba morao, mokhathala, edema ea ho potoloha, ho se sebetse hantle, asthenia, malaise, ho ruruha sefahleho, ho nona haholo, ho sithabela ka tšohanyetso, asthenia, lefu la sefuba, ho feto-fetoha ha tsoekere ea mali, ho bana - ts'oaetso ea vaerase, litaba tsa otitis.

Tekanyetso le tsamaiso

Ka hare, ho sa tsotelehe lijo.

Postherpetic neuralgia: ka letsatsi la 1 la kalafo - 300 mg / letsatsi hang, ka letsatsi la 2 - 1600 mg / letsatsi (ka litekanyetso tse 2 tse arohaneng), ka letsatsi la 3 900 900 mg / ka letsatsi (ka tekanyetso e 3 e arohaneng). Haeba ho hlokahala, ho fokotsa bohloko ka tekanyetso e latelang, o ka e eketsa ho 1800 mg / ka letsatsi (ka tekanyetso e 3 e arohaneng).

Lefu la ho akheha (e le sesebelisoa se eketsehileng): ho bakuli ba kaholimo ho lilemo tse 12 - 900-1800 mg / ka letsatsi (ho litekanyetso tse 3). Motsoako oa pele ke 300 mg makhetlo a 3 ka letsatsi, haeba ho hlokahala, eketsa lethalinyana ho 1800 mg / ka letsatsi. Tekanyetso ea letsatsi le letsatsi ha ea lokela ho feta 3600 mg. Bana ba lilemo li 3-12 - tekanyetso ea pele ea 10-15 mg / kg / letsatsi (ho litekanyetso tse 3), tekanyetso e sebetsang e khethoa ke ho tlosoa ka matsatsi a 3.

Bakeng sa bana ba lilemo tse 5 le ho feta, tekanyetso e sebetsang ke 25-35 mg / kg / letsatsi, bakeng sa bana ba lilemo li 3-4 - 40 mg / kg / letsatsi (ho litekanyetso tse 3 tse arohaneng).

Nako e phahameng pakeng tsa litekanyetso ha ea lokela ho feta lihora tse 12.

Ho felisoa ha gabapentin le / kapa ho eketsoa ha anticonvulsant e 'ngoe kalafong ho etsoa butle butle ka nako e ka etsang beke.

Ho bakuli (ba ka holimo ho lilemo tse 12) ba nang le ts'ebetso ea ho ruruha e holofetseng (tumello ea creatinine e ka tlase ho 60 ml / min) kapa bakuli ba fumanang kalafo ea hemodialysis, tekanyo e ea fokotsoa. Ka tumello ea bonyane 60 ml / Min - 900-3600 mg / ka letsatsi, ka tumello ea 30-59 ml / min - 400-1400 mg / letsatsi, 15-29 ml / min - 200-700 mg / letsatsi, ka tlase ho 15 ml / metsotso - 100-300 mg / letsatsi. Bakeng sa bakuli ba hemodialysis, tekanyetso e 'ngoe ea post-hemodialysis ke 125-350 mg ka mor'a karolo e' ngoe le e 'ngoe ea lihora tse 4.

Ho sebelisana le lithethefatsi tse ling

Tšebelisano ea bohlokoa ba kliniki pakeng tsa gabapentin le li-anticonvulsants tse ling (phenytoin, valproic acid, phenobarbital, carbamazepine), hammoho le lithibela-pelehi tsa molomo tse nang le norethisterone le / kapa ethinyl estradiol, ha li e-so thehiloe.

Li-antacids li fokotsa bioavailability ea gabapentin (lithutong ha e nkuoa le Maalox, bioavailability ea gabapentin e fokotsoe ke 20%, ha e nkuoa lihora tse 2 kamora ho nka Maalox, ka 5%).

Cimetidine hanyane e fokotsa tlhahiso ea gabapentin.

Naproxen (ka tekanyo ea 250 mg), kamoo ho hlakileng, e eketsa ho monya ha gabapentin (ka tekanyo ea 125 mg) ho tloha ho 12 ho isa ho 15%. Gabapentin ha e ame li-paraceter tsa pharmacokinetic tsa naproxen. Tšebelisano e kholo ea lithethefatsi tsena ka tekanyetso e khothalletsoang ha e tsejoe.

Morphine (60 mg) ha e nkuoa lihora tse peli kamora ho nka gabapentin (600 mg) e ile ea eketsa AUC ea gabapentin ka 44%.

Litlhoko tsa ts'ebeliso

Gabapentin ha ea lokela ho laeloa bakuli ba ka tlase ho lilemo tse 12 ba nang le ts'ebetso ea renal e fokolitsoeng (ha ho na lithuto tse entsoeng). Ho nka mehato ea ts'ireletso bakeng sa batho ba tsofetseng (ho se sebetse hantle ka lebaka la botsofe bo amanang le botsofali), lethal dose le beoa ho latela tumello ea creatinine).

Ha u ntse u nka gabapentin, ha ua lokela ho khanna makoloi le ho sebelisa lisebelisoa tse tsoetseng pele tse hlokang tlhokomelo e matla.

Litaelo tse khethehileng tsa ho amoheloa

Ha e kopantsoe le morphine, ho bohlokoa ho laola ka matla litlamorao tse hlahang ho tsoa ho tsamaiso ea methapo e bohareng. Motsoako oa gabapentin le morphine o fokotseha butle butle.

Gabapentin ha ea lokela ho nkuoa pele ho nako ea ho feta lihora tse peli ka mor'a ho nka antacid.

Ha ho khethoa protheine ho moroto o sebelisa tlhahlobo ea Ames N-Multistix SG, ho ka hlahisoa litholoana tse khothatsang tsa 'nete ka tšebeliso e kopaneng ea gabapentin le li-anticonvulsants tse ling, ka hona ho khothalletsoa ho sebelisa mekhoa e tobileng haholoanyane.

Matšoao a ho sebelisoa

Phekolo ea bohloko ba neuropathic ho batho ba baholo ho feta lilemo tse 18, monotherapy ea ho ts'oaroa ho sa ts'oaneng le ntle le kakaretso ea boemo bo phahameng ho batho ba baholo le bana ba fetang lilemo tse 12, e le sesebelisoa se eketsehileng kalafong ea ho ts'oaroa ka tsela e itseng le ntle le ho kenella ka kakaretso ho batho ba baholo le bana ba lilemo tse 3. le moholo.

Ketso ea pharmacological

Lithethefatsi tsa antiepileptic. Sebopeho sa lik'hemik'hale se tšoana le GABA, e sebetsang joaloka mokena-lipakeng oa brake har'a tsamaiso ea methapo e bohareng. Mochine oa ts'ebetso ea gabapentin ho lumeloa hore o fapane le li-anticonvulsants tse ling tse sebetsang ka GABA synapses (ho kenyelletsa le valproate, barbiturates, benzodiazepines, GABA transaminase inhibitors, GABA uptake inhibitors, GABA agonists le GABA drug.

Lebitso le sa Tšoaneleheng la Machabeng

Melao ea INN - Gabapentin.

Egipentin (Lebitso la machaba le bitsoang Gabapentin) ke setlhare se sebelisoang ho phekola lefu la sethoathoa, se tsamaeang le ho ts'oaroa ka matla.

Khethollong ea machaba ea ATX, lithethefatsi li na le khoutu N03AX12.

Lokolla liforomo le sebopeho

Phello ea pharmacological e fumaneha ka ho kenyelletsoa ha gabapentin ka har'a moriana ona. Ntle le moo, sebopeho sa moriana se kenyelletsa povidone, poloxamer, crospovidone, magnesium stearate, hydrolase.

Moriana ona o fumaneha ka tsela ea likhase, 'me e' ngoe le e 'ngoe e kenyelletsa bonyane 300 mg ea motsoako o sebetsang. Li-capsule li na le lilakane tsa 20 likhomphutha. Marang-rang a 3 kapa a 6 a ka kenngoa ka lebokoseng la karete.

Mokhoa oa ho nka egipentin?

Moriana o etselitsoe tsamaiso ea molomo. Mokhoa oa ho fokotsa litekanyetso o khethoa o nahanela botebo ba lipontšo tsa lefu lena. Maemong a mangata, tekanyetso e lekaneng ea 300 ho isa ho 600 mg ka letsatsi e lekane ho imolla matšoao. Haeba ho hlokahala, e ka nyolleloa ho 900 mg ka letsatsi.

Ka tlhokomeliso e fetelletseng, moriana o lokela ho sebelisoa haeba keketseho ea ts'ebetso ea sethoathoa ke phello ea tšenyo e bakang boko.
Moriana o etselitsoe tsamaiso ea molomo.
Phekolo ea bakuli ba nang le lefu la tsoekere mellitus, maemong a mangata, e etsoa ka tekanyetso e fokotsang.

Ho tsoa ho lisele tsa musculoskeletal le tse sebetsang

Ho sebelisa Egipentin ho ka baka bohloko bo kopaneng. Maemong a sa tloaelehang, khahlano le semelo sa ho sebelisa meriana, ho bonahala ponahalo ea edema le ho satalla ha manonyeletso, tendonitis le ramatiki. Ntle le moo, sethethefatsi sena se ka theha litabatabelo tsa ho hlaha ha bursitis, contractures ea mesifa le lefu la masapo.

Phekolo ea ka mpeng

Clinical microbiology ea Egipentin ke hore ka tšebeliso ea kamehla ea meriana, ts'ebetso e tloaelehileng ea ts'ebetso ea tšilo ea lijo e senyeha. Moriana ona o ka baka stomatitis, gastroenteritis, glossitis, esophageal hernia, proctitis, jj. Moriana o ka baka keketseho ea mali a tsoang maling. Ho feta moo, hangata bakuli ba na le litletlebo tsa bohloko ba ka mpeng.

Hematopoietic litho tsa ka hare

Ka ts'ebeliso ea Egipentin, thrombocytopenia, matšoao a phokolo ea mali le lefu la pelo a ka hlaha.

Ho sebelisa Egipentin ho ka baka bohloko bo kopaneng.
Clinical microbiology ea Egipentin ke hore ka tšebeliso ea kamehla ea meriana, ts'ebetso e tloaelehileng ea ts'ebetso ea tšilo ea lijo e senyeha.
Khahlano le nalane ea ts'ebeliso ea Egipentin, tlhaselo ea psychosis e ka hlaha.

Tsamaiso ea methapo e bohareng

Ts'ebeliso ea Egipentin e ka tsosa ho fokotseha ha maikutlo le kutloelo-bohloko ea lihlopha tse itseng tsa mesifa. Ntle le moo, motsoako o sebetsang oa lithethefatsi o ka baka ho holofala sefahlehong, ho tsoa mali ka hare le ho se sebetse hantle ha litho tsa mokokotlo. Khahlano le nalane ea ts'ebeliso ea Egipentin, maikutlo a ho phuthulloha, lipono le tlhaselo ea psychosis li ka hlaha. Ho sitisoa ha khatello ea kelello, ho robala bosiu le ts'ebelisano e senyehileng.

Ho tsoa ho tsamaiso ea methapo ea pelo

Nts'etsopele ea litla-morao tsa ho nka Egipentin ho tsoa tsamaisong ea pelo le pelo e atile haholo. Ka nako e ts'oanang, ho na le kotsi ea arrhythmia, vasodilation le tlama khatello ea mali.

Ho nka Egipentin ho ka baka cystitis le ho bolokoa ka bongata ba moriti.
Ntle le moo, moriana o ka baka nts'etsopele ea ho hloleha ha reef haholo.
Khahlano le nalane ea ho sebelisa moriana ona, ponahalo ea maikutlo a kulang, a hlalosoang e le lekhopho la letlalo, e ka khonahala.

Khahlano le nalane ea ho sebelisa moriana ona, ho ka hlaha lintho tse kulang, tse hlahisoang e le lekhopho la letlalo le boreleli, ho ruruha ha lisele tse bonolo. Maemong a sa tloaelehang, karabelo ea anaphylactic ea bonoa.

Sebelisa nakong ea bokhachane le pelehi

Ho sebetsa hantle le polokeho ea ho sebelisa moriana nakong ea kemolo le ho lactation ha ho so ka ha bonoa, ka hona, maemo ana ke tlolo ea molao bakeng sa ts'ebeliso ea Egipentin.

Bolo ba batho ba baholo ha se bosholu ba tšebeliso ea moriana, empa phetoho ea litekanyetso e ea hlokahala ho latela ts'ebetso ea liphio.
Setlhare se ka sebelisoa kalafo ea lefu la sethoathoa ho bana ba ka holimo ho lilemo tse 12.
Nako ea kemaro le ho lactation ke tlolo ea tšebeliso ea Egipentin.
Haeba u nka Egipentin e ngata haholo, letšollo le hlaha hangata.
Egipentin e ka eketsa bongata ba phenytoin ho plasma ea mali ha u ntse u e sebelisa.

Tekanyo ea joala

Ha u phekola ka meriana ena, joala ha boa lokela ho nkoa.

Meriana e nang le phello e tšoanang ea kalafo e kenyeletsa:

1. Neurontin.
2. Tebantin.
3. Gabagamm
4. Convalis.
5. Gabapentin.
6. Katena.
7. Gapantek et al.

Letlapa la Gabapentin. Lefu la ho akheha Moea oa la 16 Hlakubele 2016. HD mofuta.

Moetsi

Setlhare sena se hlahisoa ke Iberfar-Industry Pharmaceuticals.

Moetso o ts'oanang ke Neurontin.
E le mokhoa o mong, u ka khetha Tebantin.
Haeba ho hlokahala, moriana o ka nkeloa sebaka ke Convalis.

Litlhahlobo mabapi le Egipentin

Svetlana ea lilemo tse 32, Oryol

Ke ntse ke tšoeroe ke lefu la sethoathoa ho tloha bongoaneng. Hangata ke ne ke ts'oaroa ke lingaka, empa lingaka li ile tsa nka litlhare, 'me tsa emisa. Hoo e ka bang lilemo tse 3 tse fetileng, o ile a ima mme a lahleheloa ke ngoana. Khahlanong le nalane ena, tsietsi e ile ea qala hape. Ngaka e laetse Egipentin. O sebelisitse moriana likhoeli tse 6. Ke khotsofetse ke sephetho. Ha kea ka ka bona litla-morao leha e le life, empa butle-butle palo ea batho ba tsietsoeng e ile ea fokotseha. Leha taba ea hore kamohelo ea chelete e emisitse, ho se ho fetile selemo ho se motho ea nkang.

Grigory ea lilemo li 26 Vladivostok

Ke lekile lithethefatsi tse ngata ho felisa ho tsietsana ha sethoathoa. Ts'ebeliso ea Egyptin e laetsoe ke ngaka. Setlhare sena ha se nkwanele. Ho tloha ka letsatsi la pele la tsamaiso, litla-morao tse tsoang mokhoeng oa ka mpeng li ile tsa hlaha. Bohloko ba ka mpeng, ho hlatsa le lets'ollo bo entse hore ke khaotse ho sebelisa moriana.

Litla-morao

Ho tloha lehlakoreng la ts'ebetso ea methapo e bohareng le tsamaiso ea methapo ea methapo: amnesia, ataxia, pherekano, tšebelisano ea methapo, khatello ea maikutlo, ho tsekela, dysarthria, ho ts'oaroa ke letsoalo, ho ferekana, ho akheha, ho nahana hampe, ho thothomela, ho thothomela, ho akheha, diplopia, hyperkinesia, ho thatafala, ho fokolisa, ho fokolisa, ho fokolisa, ho fokolisa kapa ho fokolisa ho haelloa ke maikutlo, paresthesia, matšoenyeho, lehloeo, ho sitisoa ka molao.

Ho tsoa ho tsamaiso ea tšilo ea lijo: liphetoho mokhoeng oa ho hlohlona meno, lets'ollo, takatso e eketsehileng ea molomo, molomo o omeletseng, ho nyekeloa ke pelo, ho hlatsa, lefu la ho hlohlona, ​​ho nyemeloa, gingivitis, bohloko ba ka mpeng, pancreatitis, liphetoho liphatong tsa tšebetso ea sebete.

Ho tsoa ho sistimi ea hemopoietic: leukopenia, e fokotse palo ea lisele tse tšoeu tsa mali, thrombocytopenic purpura.

Ho tsoa ts'ebetsong ea ho hema: rhinitis, pharyngitis, khohlela, pneumonia.

Ho tsoa ts'ebetsong ea musculoskeletal: myalgia, arthralgia, masapo a masapo.

Ho tsoa ho tsamaiso ea pelo le methapo: methapo ea methapo ea kutlo, lipontšo tsa vasodilation.

Ho tsoa ts'ebetsong ea moroto: ts'oaetso ea ts'ebetso ea moroto, ho ruruha ha urinence.

Litla-morao: Matšoao a ho erythema multiforme, a Stevens-Johnson.

Boitšoaro ba letlalo: Makhopho a letlalo, makhopho, ho hlohlona, ​​lekhopho.

Tse ling: bohloko ba morao, mokhathala, edema ea ho potoloha, ho se sebetse hantle, asthenia, malaise, ho ruruha sefahleho, ho nona haholo, ho sithabela ka tšohanyetso, asthenia, lefu la sefuba, ho feto-fetoha ha tsoekere ea mali, ho bana - ts'oaetso ea vaerase, litaba tsa otitis.

Bokhachane le pelehi

Liphuputso tse lekaneng le tse laoloang ka tieo mabapi le polokeho ea gabapentin nakong ea bokhachane le ho lactation ho batho ha li e-so tšoaroe. Haeba ho hlokahala, sebelisa nakong ea bokhachane le pelehi e lokela ho lekanya melemo ea kalafo ho mme le kotsi e ka bang teng ho lesea kapa lesea.

Gabapentin e epuoa ka lebese la matsoele. Ha e sebelisoa nakong ea lebollo, mofuta oa ketso ea gabapentin ho lesea ha e thehoe.

Tšebelisano

Ha e kopantsoe le li-anticonvulsants tse ling, liphetho tsa liteko tsa moroto tse fosahetseng tsa moroto li tlalehiloe. Ho tseba protheine ka har'a morara, ho kgothaletswa ho sebelisa mokhoa o hlakileng haholoanyane oa ho silingosalicylic acid.

Ka tšebeliso e le 'ngoe le li-antacid, monko oa gabapentin o tsoang pampiring ea gastrointestinal oa fokotseha.

Ka tšebeliso e tšoanang le felbamate, keketseho ea T1 / 2 ea felbamate e khonahala.

Ka tšebeliso e ts'oanang, ho hlalositsoe nyeoe ea keketseho ea phenytoin ea plasma ea mali.

Sebelisa ho bana

Ho sebetsa hantle le polokeho ea kalafo bakeng sa bohloko ba neuropathic ho bakuli ba ka tlase ho lilemo tse 18 ha e-so theoe.

Ho sebetsa hantle le polokeho ea gabapentin monotherapy kalafong ea ho ts'oaroa ka mokhoa o sa sekisetseng ho bana ba ka tlase ho lilemo tse 12 le kalafo e eketsehileng ea gabapentin kalafong ea ho ts'oaroa ho sa lekanyetsoang ho bana ba ka tlase ho lilemo tse 3 ha e so theoe