Matlapa a Glyclazide 30 mg: litaelo tsa tšebeliso

Hypoglycemic agent, eo e leng karolo ea moloko oa sulfonylurea II. E hlohlelletsa tlhahiso ea insulin ke lisele tsa β hape e khutlisa boemo ba eona ba mmele. Ho nwa moriana ho fokotsa nako ho tloha motsotso oa ho ja ho fihlela qalong ea secretion, hobane e khutlisetsa karolo ea pele (ea pele) ea secretion mme e ntlafatsa karolo ea bobeli. Fokotsa tsoekere e phahameng haholo ka mor'a ho ja. E eketsa kutloisiso ea mesifa ho insulin.
Ho feta moo, e fokotsa likotsi. thrombosiska ho hatella kopanelo le khokahanyo palo ea liplateleteho tsosolosa parietal ea 'mele fibrinolysise ntlafatsa microcirculation. Matla ana a bohlokoa hobane a fokotsa kotsi ea mathata a maholo - retinopathies le microangiopathies. Ka lefu la tsoekere lephofo, ho na le ho fokotseha proteinuria Khahlano le nalane ea kalafo ka sethethefatsi sena. E thibela nts'etsopele ea atherosulinosis, kaha e na le thepa ea anti-atherogenic.

Litšobotsi tsa foromo ea litekanyetso Gliclazide MV fana ka ts'ebeliso e matla ea kalafo le taolo ea litekanyetso tsa tsoekere ka nako ea lihora tse 24.

Mofumahali

Ho kenella ka potlako ka har'a tšilo ea lijo, tekanyo ea ho monya e phahame. Khatiso e kholo (ha e nkuoa 80 mg) e khethoa kamora lihora tse 4. Puisano le liprotheine ho fihla ho 97%. Ts'oarello ea tekano e fihlelloa ka mor'a tsamaiso bakeng sa matsatsi a mabeli. E etselitsoe sebeteng ho ea ho li-metabolites tse 8. Ho fihlela 70% e epollotsoe ke liphio, mala - 12%. Ho felisoa ha halofo ea bophelo ba gliclazide e tloaelehileng ke lihora tse 8, nako e telele ho lihora tse 20.

Contraindication

• insulin e itšetlehileng ka lefu la tsoekere,
• ketoacidosis,
• lefu la tsoekere,
• e matla renal / dysfunction
• congenital lactose tsietsing, malabsorption syndrome,
• kamohelo e le 'ngoe le Danazol kapa Phenylbutazone,
• lilemo tse 18
• hypersensitivity
• ho ima, ho nyeka.

E laetsoe ka hloko botsofaling, ka phepo e sa tloaelehang, hypothyroidism, hypopituitarismthata Lefu la pelo ea Ischemicmme e phatlalalitsoe atherosulinosis, ho hloleha ha adrenalkalafo ea nako e telele glucocorticosteroids.

Litlamorao

• ho nyekeloa ke pelo, ho hlatsa, bohloko ba ka mpeng,
• thrombocytopenia, erythropenia, agranulocytosis, hemolytic anemia,
• allergic vasculitis,
• lekhopho la letlalo, ho hlohlona,
• ho hloleha ha sebete,
• ho sitisoa hoa pono
• hypoglycemia(molemong oa overdose).

Glyclazide, litaelo tsa tšebeliso (Mokhoa le litekanyetso)

Matlapa a Glyclazide e behiloeng ka tekanyetso ea pele ea letsatsi le letsatsi ea 80 mg, ho nkuoa makhetlo a 2 ka letsatsi metsotso e 30 pele ho lijo. Nakong e tlang, tekanyetso ea fetoloa, 'me karolelano ea letsatsi le letsatsi ea lijo ke 160 mg,' me boholo ba eona ke 320 mg. Matlapa a Glyclazide MB a ka lemoha matlapa a lokolloang khafetsa. Monyetla oa ho khutlisoa le lethalamo ho sena ke qeto ea ngaka.

Glyclazide MB 30 mg nka nako e le 1 ka letsatsi nakong ea lijo tsa hoseng. Phetoho ea tekanyetso e etsoa kamora libeke tse peli tsa kalafo. E ka ba 90 -120 mg.

Haeba u fetoa ke pilisi u ke ke ua nka tekanyetso e habeli. Ha o kenya sethethefatsi se seng se theolang tsoekere ka sena, nako ea phetoho ha e hlokehe - ba qala ho e nka ka le hlahlamang. Mohlomong motsoako le biguanides, insulinalpha glucosidase inhibitors. Bakeng sa bonolo ho isa tekanyong ho hloleha ha rems khethoa ka tekanyetso e tšoanang. Ho bakuli ba kotsing ea hypoglycemia, ho sebelisoa lethal e fokolang.

Bongata

Tekanyetso e feteletseng e bonahatsoa ke matšoao a hypoglycemia: hlooho ea hlooho, mokhathala, bofokoli bo matla, ho fufuleloa, palpitations, khatello e phahameng ea mali, arrhythmiaho otsela ho ferekanaho ba mabifi, ho se tsikinyehe, ho lieha ho arabela, ho sitisa pono le puo, thothomelaho tsekela cramps, bradycardiaho lahleheloa ke kelello.

Le ka tekano hypoglycemiau sa tsebe letho ka letho, fokotsa tekanyo ea lithethefatsi kapa eketsa bongata ba lik'habohaedreite tse fanoang ke lijo.

Maemong a matla a hypoglycemic, ho kena sepetlele hang-hang le thuso lia hlokahala: iv 50 di-100 tsa tharollo ea glucose ea 20-30%, ebe tharollo ea 10% dextrose kapa glucose ke drip. Matsatsing a mabeli feela, boemo ba tsoekere bo hlahlojoe. Ho foufatsa ha e na thuso.

Tšebelisano

Tšebeliso e kopanetsoeng le Cimetidinee eketsang khatello ea maikutlo gliclazidee ka lebisang ho hypoglycemia e matla.

Ha e sebelisoa le Verapamil o hloka ho laola boemo ba tsoekere.

Phello ea hypoglycemic e na le ts'oaetso ha e sebelisoa le li-salicylatestse tsoang Pyrazolone, sulfonamides, kofi, Phenylbutazone, Theophylline.

Ts'ebeliso ea li-blocker tsa beta tse seng khetho e eketsa kotsi hypoglycemia.

Ha o etsa kopo Acarboseletšoao le tlatsetsang la hypoglycemic.

Ha o sebelisa GCS (ho kenyelletsa mekhoa ea kantle ea kopo), barbiturates, diuretics, estrogenle li-progestin, Diphenin, Rifampicin phello e fokotsang tsoekere ea lithethefatsi ea fokotseha.

Litlhahlobo mabapi le Gliclazide

Hajoale, li-derivatives li sebelisoa haholo.meloko II sulfonylureas, eo Gliclazide e leng ea eona, hobane e phahame ho lithethefatsi tsa moloko o fetileng ka sehloho sa phello ea hypoglycemic, hobane tšebelisano ea "li-receptors tsa cell-cell" e makhetlo a 2-5, e lumellang ho fihlela sephetho ha ho fanoa ka litekanyetso tse fokolang. Moloko ona oa lithethefatsi o na le monyetla o fokolang oa ho baka litlamorao.

Karolo ea lithethefatsi ke hore li-metabolites tse 'maloa li thehoa nakong ea liphetoho tsa metabolic,' me e 'ngoe ea tsona e na le phello e kholo ho microcirculation. Boithuto bo bongata bo bontšitse kotsi e fokotsehileng ea mathata a microvascular (retinopathyle nephropathy) kalafong gliclazide. Botebo bo fokotsehile angiopathy, phepo ea khokahano e ntlafatsa, ea nyamela vascular stasis. Ke ka lebaka leo e laetsoeng mathata lefu la tsoekere (angiopathy, nephropathyka ho hloleha ho phekola renal ho sa feleng, retinopathies) mme sena se tlaleheloa ke bakuli bao, ka lebaka lona lena, ba fetiselitsoeng ho nka moriana ona.

Ba bangata ba hatella hore matlapa a lokela ho nooa kamora lijo tsa hoseng, tse nang le lik'habohaedreite tse ngata, tlala ea mots'eare ha e lumellehe. Ho seng joalo, khahlano le semelo sa lijo tse nang le khalori e tlase le kamora ho ikoetlisa ka matla ho ntlafatsa mmele hypoglycemia. Ka khatello ea maikutlo, hoa hlokahala ho fetola tekanyetso ea lithethefatsi. Kamora ho noa joala, batho ba bang le bona ba ile ba ba le maemo a hypoglycemic.

Batho ba baholo ba tsotella haholo lithethefatsi tsa hypoglycemic, kaha menyetla ea bona ea ho ba le hypoglycemia e eketseha. Kamanong ena, ho molemo ho sebelisa lithethefatsi tse nkang nakoana (tse tloaelehileng) gliclazide).
Bakuli ba hlokometse litlhahlobo tsa bona bonolo ba ho sebelisa matlapa a lokolotsoeng a lokolloang: ba sebetsa butle butle hape ka ho lekana, ka hona ba sebelisoa hanngoe ka letsatsi. Ntle le moo, tekanyetso ea eona e sebetsang ke makhetlo a 2 a tlase ho tekanyetso e tloaelehileng gliclazide.

Ho na le litlaleho tsa hore kamora lilemo tse 'maloa (ho tloha ho 3 ho isa ho 5 ho tloha qalong ea ts'ebetso), ho hanyetsa ho thehiloe - ho fokotseha kapa ho hloka ts'ebetso ea lithethefatsi. Maemong a joalo, ngaka e ile ea khetha motsoako oa li-agents tse ling tsa hypoglycemic.

Tekanyetso le tsamaiso

Ho khothalletsoa ho metsa letlapa lohle nakong ea lijo tsa hoseng ntle le ho hlafuna. Tekanyetso ntlheng ka 'ngoe e lokela ho khethoa ka bonngoe, ho latela boemo ba tsoekere maling le glycosylated hemoglobin.

Tekanyetso ea pele e khothalletsoang ho batho ba baholo (ho kenyeletsoa le ba holileng ≥ lilemo tse 65) ke 30 mg / ka letsatsi. Tabeng ea taolo e lekaneng, lithethefatsi ka tekanyetso ena li ka sebelisoa bakeng sa kalafo ea tlhokomelo. Ka taolo e sa lekaneng ea glycemic, tekanyetso ea letsatsi le letsatsi e ka eketsoa ka ho latellana ho 60 mg, 90 mg kapa 120 mg. Keketseho ea lethal dose e khonahala eseng pele ho khoeli ea 1 ea kalafo ka tekanyetso e boletsoeng esale pele. Sekhahla sa letsatsi le letsatsi ke 30-120 mg ka tekanyetso e le 'ngoe. Sekhahla se phahameng se khothalletsoang letsatsi le letsatsi ke 120 mg. Haeba u lahleheloa ke tekanyetso e le 'ngoe kapa tse' maloa tsa lithethefatsi, u ke ke ua nka tekanyetso e phahameng ho lethal e latelang, tekanyetso e lahlehileng e lokela ho nooa ka le hlahlamang.

Ho tloha ho nka gliclazide e sa tsoaloang ho gliclazide 30-25 matlapa a lokolotsoeng a ntlafalitsoeng: 1 tab. 80 mg e tloaelehileng ea ho lokolla gliclazide e ka nkeloa sebaka ke 1 tab. 30 mg e lokolotsoeng glyclatone. Ha ho fetisoa ha bakuli ho tsoa gliclazide ea lithethefatsi 80 mg ho gliclazide MV 30 mg, ho khothalletsoa ho lekola boemo ba tsoekere ea mali ka hloko.

Ts'ebeliso e kopantsoeng le lithethefatsi tse ling tsa hypoglycemic: Glyclazide-Borimed MV 30 mg e ka sebelisoa hammoho le li-biguanidins, alpha-glucosidase inhibitors kapa insulin.

Ka taolo e sa lekaneng ea glycemic, kalafo ea "insulin" e eketsoa ka tlhokomelo e hlokolosi ea bongaka.

Ho khahlisoa ha litekanyetso tsa moriana ho batho ba ka holimo ho lilemo tse 65, hammoho le ho bakuli ba sa sebetseng hantle haholo ka moriong o fokolang, ha ho hlokahale.

Litla-morao

Ho tsoa ts'ebetsong ea tšilo ea lijo: dyspepsia (ho nyekeloa, ho hlatsa, lets'ollo, bohloko ba ka mpeng, ho sokela) - khatello e fokotseha ka lijo, ka seoelo - ho senyeha ha sebete (hepatitis, cholestatic jaundice - ho hloka ho khaoloa hoa moriana, ts'ebetso e eketsehileng ea "lipilisi" tsa "sebete", alkaline phosphatase).

Ho tsoa lithong tsa hemopoietic: inhibition of marrow hematopoiesis (anemia, thrombocytopenia, leukopenia, granulocytopenia).

Litla-morao: ho hlohlona ha letlalo, urticaria, lekhopho la letlalo, ho kenyeletsoa maculopapular and bullous), erythema, allergic vasculitis.

Lipontšo tsa hypoglycemia: ho tsekela, ho tepella, ho otsela, ho opeloa ke hlooho le ho fufuleloa, bofokoli, ho tšoha, ho thothomela, paresthesia. Matšoao a mang a ho ba teng ha hypoglycemia: tlala, likotsi tsa boroko, ho ferekana, ho ba mabifi, ho tsepamisa mohopolo, ho fokotsa ho se tsitsane, khatello ea maikutlo, pherekano, mathata a pono le puo, aphasia, paresis, maikutlo a ferekanyang, maikutlo a ho hloka matla, ho lahleheloa ke boitaolo, ho lematsa, ho qhoqha moea, ho hema khafetsa, bradycardia, ho otsela le ho felloa ke letsoalo, tse ka lebisang ho akheha le lefu.

Ntle le moo, matšoao a ho hanyetsa ha adrenergic a ka ba teng, joalo ka ho fufuleloa, letlalo le loanang, ho tšoenyeha, tachycardia, khatello e phahameng ea mali, pelo ea pelo, angina pectoris, le pelo. Ka tloaelo, liponahatso tsena tsa kliniki hangata lia nyamela kamora ho nka limatlafatsi (tsoekere). Lisebelisoa tsa monko o monate oa maiketsetso ha li na phello ea ho emisa hypoglycemia. Phihlelo ea ho sebelisa litokisetso tse ling tsa sulfonylurea e bontša monyetla oa ho khutlisetsa hypoglycemia esita le maemong ao ha mehato e nkiloeng ho e felisa qalong e ne e bonahala e sebetsa. Litlhaselong tse matla le tse tsoelang pele tsa hypoglycemia, le haeba e ka felisoa ka nakoana ka ho nka tsoekere, ho hlokahala tlhokomelo ea bongaka ka potlako kapa ho kena sepetlele.

Ho sitisoa ha pono: Ho ferekana ha nakoana hoa bonoa hoa khoneha, haholo qalong ea kalafo, ka lebaka la liphetoho maemong a tsoekere ea mali.

Ho tsoa ho tsamaiso ea methapo ea pelo: arteritis, ho nyekeloa ke pelo, ho nyekeloa ke pelo, ho se lekane hantle ha mokokotlo, nosebleeds, coronary artery insuffence, hypotension, edema ea leoto, palpitations, tachycardia, thrombophlebitis.

Likarolo tsa ts'ebeliso

E ka fuoa feela bakuli bao lijo tsa bona li leng teng khafetsa 'me li kenyelletsa lijo tsa hoseng. Ho bohlokoa haholo ho boloka tšebeliso e lekaneng ea lik'habohaedreite ka lijo, joalo ka kotsi ea ho ba le hypoglycemia e eketseha ka khaello ea phepo e nepahetseng kapa khaello ea phepo e nepahetseng, hammoho le tšebeliso ea lijo tse haelloang ke lik'habohaedreite. Hypoglycemia hangata e hlaha ka ho ja lijo tse nang le khalori e tlase, ka mor'a ho ikoetlisa ka nako e telele kapa ka matla, ka mor'a ho noa joala, kapa ha u sebelisa lithethefatsi tse 'maloa tsa hypoglycemic ka nako e le' ngoe. Ka tloaelo, matšoao a hypoglycemia a nyamela kamora ho ja lijo tse nang le lik'habohaedreite tse ngata (tse kang tsoekere). Re lokela ho hopola hore ho nka li-sweeteners ha ho thusa ho tlosa matšoao a hypoglycemic. Hypoglycemia e ka khutla le ha boemo bona bo ka ba teng. Maemong matšoao a hypoglycemic a boletsoe kapa a nka nako e telele, le maemong a ntlafatso ea nakoana kamora ho ja lijo tse nang le lik'habohaedreite, ho hlokahala tlhokomelo ea tšohanyetso ea bongaka, ho fihlela sepetlele.

Ha u ntse u sebelisa lithethefatsi, ho hlokahala boikemisetso ba ho itima lijo ka glucose le gbcylylated Hb.

Mafu a tšoaetsanoang a nang le febrile syndrome a ka hloka ho felisoa ha lithethefatsi tsa hypoglycemic ea molomo le tsamaiso ea insulin.

Bakuli ba lokela ho lemosoa ka kotsi e eketsehang ea hypoglycemia maemong a ho nka lithethefatsi tse nang le ethanol le ethanol (ho kenyelletsa le ts'ebetso e kang ea disulfiram: bohloko ba ka mpeng, ho nyekeloa, ho hlatsa, hlooho), li-NSAID, le tlala.

Phetoho ea tekanyetso ea hlokahala bakeng sa ho fetella hoa mmele le maikutlo, phetoho ea lijo.

Kotsi e eketsehileng ea ho ba le hypoglycemia e bonoa maemong a latelang: ho hana ha mokuli kapa ho se khonehe (haholo-holo maqheku) ho latela litaelo tsa ngaka le ho laola boemo ba hae, lijo tse sa lekanang le tse sa tloaelehang, ho tlōla lijo, ho itima lijo le ho fetola lijo, ho se lekane pakeng tsa ts'ebetso ea 'mele le palo ea lik'habohaedreite tse nkiloeng, renal ho haella kapa ho hloleha ho matla ha sebete, ho ata ha MV gliclazide, mathata a mang a endocrine (lefu la qoqotho, pituitary le ho hloleha ha adrenal).

Bakeng sa bakuli ba nang le bothata bo matla ba hepatic le / kapa renal, ho na le phetoho mokhoeng oa pharmacokinetic le / kapa oa pharmacodynamic oa gliclazide. Hypoglycemia e hlahang ho bakuli bana e ka ba telele haholo, maemong a joalo, ho hlokahala kalafo e loketseng hanghang.

Hoa hlokahala ho tsebisa mokuli le litho tsa lelapa la hae ka kotsi ea ho ba le hypoglycemia, matšoao a eona le maemo a tsamaisanang le kholo ea eona. Mokuli o tlameha ho tsebisoa ka likotsi le melemo ea kalafo e boletsoeng. Mokuli o hloka ho hlakisa bohlokoa ba ho ja, tlhoko ea ho ikoetlisa khafetsa le ho lekola maemo a tsoekere ea mali kamehla.

Nakong ea kalafo, tlhokomelo e lokela ho nkuoa ha ho khannoa likoloi le ho etsa lintho tse ling tse ka bang kotsi tse hlokang ho tsepamisa mohopolo le ho potlakisa karabelo ea psychomotor.

Litlhokahalo tsa polokeho

Ho tsofala, ho se lekane le / kapa phepo e sa leka-lekanang, mafu a matla a tsamaiso ea methapo ea pelo (ho kenyelletsa le lefu la pelo la pelo, atherosclerosis), hypothyroidism, ho hlaka kapa ho hloleha hoa setho, hypopituitarism, renal le / kapa ho hloleha ha sebete, kalafo ea glucocorticosteroid ea nako e telele. , khaello ea glucose-6-phosphate dehydrogenase, phekolo e kopaneng le phenylbutazone le danazole.

Hypoglycemia Phekolo ea Gliclazide e ka fuoa feela bakuli ba ka fanang ka lijo tsa kamehla (ho kenyeletsa le lijo tsa hoseng).Kotsi ea hypoglycemia e eketseha ka lijo tse nang le khalori e fokolang, ka mor'a ho ikoetlisa ka nako e telele kapa ho ikoetlisa ka ho feteletseng, ho noa joala kapa maemong a ts'ebeliso ea lithethefatsi tse 'maloa tsa hypoglycemic tse tsoang sehlopheng sa sulfonylurea.

Ho haelloa ke sebete kapa tšebetso ea meno. Ho bakuli ba joalo, likarolo tsa hypoglycemia li kanna tsa ba telele, tse hlokang ho amoheloa mehato e lekaneng.

Ho sebetsa hantle ha moriana leha e le ofe oa hypoglycemic ea molomo, ho kenyelletsa le gliclazide, ho bakuli ba bangata ho fokotseha ha nako e ntse e feta: sena se ka ba ka lebaka la tsoelo-pele ea lefu la tsoekere kapa karabelo e fokolisang ea moriana.

Sokolla foromo le sebopeho

Foromo ea litekanyetso - matlapa a lokolotsoeng a emeng: hoo e batlang e le bosoeu kapa bosoeu, biconvex, 30 mg le 60 mg oval, 90 mg, sebopeho sa sefahleho, G90 e ngotsoe ka lehlakoreng le le leng (30 mg: 10 likhomphutha.) , ka har'a lebokose la mekotla e 3, e 6 kapa ea 9, e 'ngoe le e ngoe e na le lithutsoana, likhaketeng tse 2, 4 kapa 6, 60 mg ka ngoe: li-pcs tse 15 ho blister, ka lebokoseng la likhara tse 2, 4, 6 kapa 8. , 90 mg: li-pcs tse 10. ka blister, ka lebokoseng la mekotla e meraro ea 3, 6 kapa 9).

Letlapa le le leng le na le:

• ntho e sebetsang: gliclazide - 30 mg, 60 mg kapa 90 mg,
• li-excipients: hypromellose (100 mPas - viscosity ea lebitso bakeng sa tharollo ea metsi ea 2%), lactose monohydrate, colloidal silicon dioxide, magnesium stearate.

Ntle le moo, matlapeng a 30 mg - hypromellose (4000 mPas), calcium carbonate.

Matšoao a ho sebelisoa

Tšebeliso ea Glyclades e bontšoa bakeng sa kalafo ea bakuli ba baholo ba nang le lefu la tsoekere la mofuta oa 2 ka ho se sebetse hantle hoa kalafo ea ho ja, ho ikoetlisa 'meleng le ho theola boima ba' mele.

Ntle le moo, moriana o laetsoe bakeng sa thibelo ea mathata ho bakuli ba nang le lefu la tsoekere la mofuta oa 2: ho fokotsa kotsi ea likotsi tsa microvascular (retinopathy, nephropathy) le macrovascular (myocardial infarction, stroke).

Tekanyetso le tsamaiso

Matlapa a nooa ka molomo nakong ea lijo tsa hoseng, nako e le 1 ka letsatsi.

Tekanyo ea Glyclades e fanoa ka bonngoe ho ipapisitsoe le boemo ba hemoglobin ea glycosylated (HbAlc) le ho lekola khafetsa khatello ea mali maling.

Khothaletso ea letsatsi le letsatsi e khothalelitsoeng: tekanyetso ea pele ke 30 mg, haeba lethal dose lena le u lumella ho fihlela sephetho se nepahetseng sa kliniki, se nkuoa e le phepelo. Ha ho na le taolo e hlokahalang ea glycemic, lethalinyana le lokela ho eketseha butle-butle (ho nahanela tsoekere ea mali maling) ho 60 mg, 90 mg kapa 120 mg ka letsatsi. Haeba phokotso ea khatello ea tsoekere ea mali e etsahala nakong ea libeke tse peli tsa kalafo, lethal dose le ka eketsoa ka nako ea libeke tse 4 kapa ho feta. Haeba kamora libeke tse peli tsa ho sebelisa moriana, khatello ea tsoekere maling e sa fokotsehe, tekanyetso e lokela ho eketsoa qetellong ea beke ea bobeli ea kalafo.

Sekhahla se phahameng sa letsatsi ke 120 mg.

Ha o fetoha ho nka litafole tsa tokollo tsa hang-hang tse nang le 80 mg ea glyclazide, ho lokela ho hopoloa hore sephetho sa letlapa le le leng le joalo le lekana le 30 mg ea letlapa la Gliclada. Ho fetola moriana ho lokela ho tsamaisana le ho shebella ka hloko khatello ea tsoekere maling.

Tekanyetso ea pele ea moriana ha o tloha tekanyetso efe kapa efe (esita le e phahameng) ea ea pele

hypoglycemic oral agents e lokela ho ba 30 mg. Maemong ana, ho hlokahala hore ho nahanoe ka tekanyetso, katleho le nako ea ts'ebetso ea moemeli ea fetileng.

Haeba moemeli oa hypoglycemic ea pejana a ne a bile le T e telele_1/2bakeng sa ho thibela ts'ebetso e eketsang le nts'etsopele ea hypoglycemia, ho khaotsa kalafo ea nakoana (matsatsi a 'maloa) ho ka khoneha. Kamora ho qala kalafo, ho hlokahala hore u tsamaee le libeke tse 1-2 ka hloko ho hlahloba boemo ba mokuli.

Setlhare se ka sebelisoa hammoho le li-Biguanides, tse hlahisoang ke thiazolidatedione, alpha-glucosidase inhibitors kapa insulin.

Ho qala kalafo hammoho le insulin ho hlokahala ka tlhahlobo e hlokolosi ea bongaka.

Ka botebo le bo itekanetseng ba ho se sebetse hantle ha renal, clearinine clearance (CC) ea 15-80 ml / min, kalafo ea bakuli ba lilemo tse fetang 65 ha e hloke tokiso ea tekanyetso.

Ho fihlela boemo ba sepheo sa HbAlc, ho ekelletsa ho keketseho ea butle-butle ea tekanyetso ea moriana, ho bohlokoa ho latela lijo tse khethehileng le ho ikoetlisa.

Litaelo tse khethehileng

Nakong ea ts'ebeliso ea Glyclades, mokuli o lokela ho latela lijo tse tloaelehileng, a netefatse ho kenyelletsa lijo tsa hoseng, hobane tšebeliso e sa tloaelehang ea lik'habohaedreite, lijo tsa morao kapa tse sa lekaneng li eketsa kotsi ea hypoglycemia. Matšoao a hypoglycemia: tlala e matla, ho opeloa ke hlooho, ho nyekeloa, ho hlatsa, ho felloa ke matla, ho ba mabifi, ho teneha, ho fokola haholo, ho hloka boroko, ho otsela, ho ferekana, ho sitoa ho bona hantle, ho se tsebe ho tsepamisa mohopolo Ho ferekana ha maikutlo, ho felloa ke matla a ho itaola, ho tsitsipana, delirium, bradycardia, phefumoloho e sa tebang, ho lahleheloa ke letsoalo. Ntle le moo, mokuli a ka ba le mofufutso o eketsehileng, ho tšoenyeha, khatello ea mali e eketsehileng, tachycardia, palpitations, angina pectoris, cardiac arrhythmias, clammy le letlalo le batang.

Ho emisa karabelo ea hypoglycemic, ho hlokahala ho nka lik'habohaedreite (tsoekere), maemong a matla, ho hlokahala tlhokomelo ea bongaka ea tšohanyetso (glucose ea methapo).

Ts'ebeliso ea ho itlhahloba ea boemo ba khatello ea tsoekere maling plasma e u lumella ho rekota phetoho maemong a mokuli.

Ho khomarela ka thata kalafo ea litekanyetso - ho nka moriana nakong ea lijo tsa hoseng - ho fokotsa monyetla oa ho ba le litlamorao tse sa batleheng ka mokhoa oa dyspepsia.

Ha matšoao a jaundice ea cholestatic a hlaha, matlapa a lokela ho khaoloa.

Ho tsamaellana le lijo tse nang le khalori e tlaase, ho ikoetlisa nako e telele kapa ho ikoetlisa ka matla, tšebeliso e le 'ngoe ea baemeli ba bang ba hypoglycemic, tšebeliso ea joala kapa lithethefatsi tse ngata tse feteletseng li eketsa kotsi ea hypoglycemia.

Lintho tse eketsang kotsi ea hypoglycemia li kenyelletsa li-pathologies tse amanang le eona: ho se sebetse hantle ha masapo, ho se sebetse hantle ha sebete, lefu la qoqotho, ho hloka khaello ea pituitary-adrenal, hypopituitarism. Ho fetola thepa ea gliclazide ho hepatic kapa ho hloleha haholo ha renal ho ka etsa hore mokuli a hlahe nako e telele ea hypoglycemia.

U ke ke ua tsosa botsitso lipakeng tsa palo ea lik'habohaedreite tse sebelisoang, ho ikoetlisa 'meleng le khatello ea maikutlo.

Ts'ebeliso ea lithethefatsi tse ling e kopantsoe ntle le ho buisana le ngaka.

Ho fokotseha hoa phello ea kalafo ea "hypoglycemic" ea molomo ho ka hlaha le lefu la mokokotlo, khatello ea maikutlo, mafu a tšoaetsanoang, ho chesoa haholo le ts'ebetso ea bongaka e sebelisang thipa. Maemo ana a ka lebisa ho tlhoko ea ho fetisetsa mokuli kalafo ea insulin.

Re lokela ho hopola hore tšebeliso ea nako e le 'ngoe ea beta-blockers, reserpine, clonidine, guanethidine e ka pata lipontšo tsa bongaka tsa hypoglycemia.

Ka ho fokotseha hoa phello ea kalafo ea lithethefatsi kamora kalafo ea nako e telele, ngaka e lokela ho etsa bonnete ba hore mokuli o latela litlhahiso tsa regimen regimen, lijo le boikoetliso ba 'mele. Haeba mokuli a ba latela ka hloko, joale ho fokotseha ha taolo ea glycemic ho bakoa ke ho tsoela pele ha lefu lena.

Ts'ebeliso ea li-glycases haeba ho na le khaello ea glucose-6-phosphate dehydrogenase e ka baka nts'etsopele ea anemia ea hemolytic.

Nakong ea ts'ebeliso ea lithethefatsi, ho khothalletsoa hore bakuli ba nang le lefu la tsoekere ba lemale ha ba khanna makoloi le menyako.

Ho sebelisana le lithethefatsi

Ka tšebeliso e tšoanang ea Glyclades:

• miconazole, phenylbutazone, danazole, ethanol li etsa hore ho be le keketseho e kholo litlamorao tsa moriana, ho eketsa kotsi ea hypoglycemia, koma,
• insulin, biguanides, acarbose, beta-blockers, sulfonamides, angiotensin e fetolang enzyme inhibitors (enalapril, Captopril), fluconazole, cimetidine, monoamine oxidase inhibitors, lithethefatsi tse seng khahlanong le ts'oaetso ea motsoako ,cacithromycin
• chlorpromazine e phahameng (haholo ho feta 100 mg ka letsatsi) tekanyetso e eketsa boemo ba glucose maling, e fokotsa sekhahla sa insulin.
• tetracosactide, GCS ea systemic, intraarticular, kantle le tšebeliso ea rectal e eketsa kotsi ea ho ba le ketoacidosis,
• salbutamol, ritodrin, terbutaline e eketsa tsoekere ea mali,
• warfarin le li-anticoagulants tse ling li ntlafatsa phello ea tsona ea kalafo.

Litaba tsa Gliklad ke tsena: matlapa - Diabeteson MV, Gliclazide MV, Diabefarm MV, Glidiab.

Foromo ea litekanyetso

30 mg le 60 mg lipilisi tsa tokollo tse fetotsoeng

Letlapa le leng le na le:

ntho e sebetsang - gliclazide 30.0 mg kapa 60.0 mg,

Baeti: silicon dioxide e nang le lero "colloidal" hydroxypropyl methylcellulose, sodium stearyl fumarate, talc, lactose monohydrate.

Matlapa a tšoeu kapa a batla a soeufetse ka 'mala, a chitja ka sebopeho sa cylindrical le bevel (bakeng sa litekanyetso tsa 30 mg).

Matlapa a tšoeu kapa a batla a soeufetse ka 'mala, a chitja ka sebopeho sa cylindrical, facet le notch (bakeng sa litekanyetso tsa 60 mg).

Melemo ea pharmacological

Mofumahali

Kamora ho tsamaisoa ka molomo, gliclazide e kenella ka botlalo ho tsoa pampiring ea gastrointestinal. Ho ja ha ho ame boemo ba ho monya. Khetla ea gliclazide ho plasma e eketseha hanyane ka hanyane nakong ea lihora tsa pele tsa 6 kamora tsamaiso mme e fihla sehlabeng se phehellang ho tloha ka la 6 ho isa ho la 12. Phapang e fapaneng ea batho ba babeli e batla e le tlase. Kamano pakeng tsa lethal dose ho fihlela ho 120 mg le mokokotlo oa plasma ea lithethefatsi ke ho itšetleha ka nako. Hoo e ka bang 95% ea lithethefatsi li tlama ho protheine ea plasma.

Gliclazide e tšelisoa haholo-holo ka har'a sebete 'me e tšeloa ka bongata moroto. Excretion e etsoa haholo ke liphio ka sebopeho sa metabolites, e ka tlase ho 1% e fetotsoe e sa fetoloe ka har'a moroto. Ha ho na metabolites e sebetsang ho plasma.

Halofo ea bophelo (T1 / 2) ea karolelano ea lihora tse 16 (lihora tse 12 ho isa ho tse 20).

Ho batho ba tsofetseng, ha ho na liphetoho tse kholo maemong a pharmacokinetic.

Tekanyetso e le 'ngoe ea letsatsi le letsatsi ea 60 mg e fana ka pokello e sebetsang ea gliclazide ho plasma nako e fetang lihora tse 24.

Pharadodynamics

Gliclazide MV ke lithethefatsi tse tsoang molomong oa sehlopha sa II sa sulfonylurea, se fapaneng le lithethefatsi tse tšoanang ka ho ba le selikalikoe se nang le heterocyclic sa N se nang le endocyclic bond.

Gliclazide MB e fokotsa sekhahla sa tsoekere maling, e thusa ho boloka sekhahla sa insulin ke li-β-cell tsa li-islets tsa Langerhans. Kamora kalafo ea lilemo tse peli, bakuli ba bangata ba ntse ba e-na le keketseho ea boemo ba insulin ea postprandial le secretion ea C-peptides.

Ho mofuta oa 2 lefu la tsoekere, lithethefatsi li khutlisa tlhoko ea pele ea "insulin secretion" ho arabela tšebeliso ea tsoekere le ho matlafatsa karolo ea bobeli ea seculin ea insulin. Keketseho e kholo ea secretion ea insulin e bonoa ho arabela ts'usumetso ka lebaka la ho ja lijo le tsamaiso ea tsoekere.

Gliclazide MV e na le phello ho microcirculation. E fokotsa kotsi ea "thrombosis" e nyane ea methapo ea mali, e amang mekhoa e mmedi e ka amehang ho nts'etsopele ea mathata a lefu la tsoekere: ho thibela likarolo tsa methapo le ho khomarela le ho fokotseha ha lintho tse ngata tse amanang le tsamaiso ea liplatele (beta-thromboglobulin, thromboxane B2) vasotine endothelium le tšebetso e eketsehang ea activator ea plasminogen.

Ho sebelisana le lithethefatsi

Lithethefatsi tse eketsang phello ea Gliclazide MV (kotsi e eketsehang ea hypoglycemia)

Miconazole (ha e sebelisoa ka mokhoa o hlophisehileng kapa e sebelisoa ho mucosa ea mokokotlo oa molomo ka mokhoa oa gel): e ntlafatsa phello ea hypoglycemic ea MV Gliclazide (hypoglycemia e ka nyoloha ho fihla ho hypoglycemic coma).

Ha e khothalletsoe hore e sebelisoe:

Phenylbutazone e ntlafatsa phello ea hypoglycemic ea lintho tse tsoang ho sulfonylurea (e li tlosa hole le puisano le liprotheine tsa plasma le / kapa e liehisa ho tsoa ha tsona 'meleng).

Ho molemo ho sebelisa sethethefatsi se seng se thibelang mafu.

Joala bo ntlafatsa hypoglycemia, bo thibela tšusumetso e bang teng, bo ka kenya letsoho kholisong ea komello ea hypoglycemic.

Hoa hlokahala ho lahla tšebeliso ea joala le ho sebelisa meriana, e kenyeletsang joala.

Mekhaako e hlokang ho ba hlokolosi:

Tšebeliso e tšoanang ea lithethefatsi tse latelang e ka mpefatsa phello ea hypoglycemic ea lithethefatsi Gliclazide MV mme maemong a mang e lebisa ho qaleheng ha hypoglycemia:

lingaka tse ling tsa antidiabetesic (insulin, acarbose, biguanides), beta-blockers, fluconazole, angiotensin-converting enzyme inhibitors (Captopril, enalapril), H2 receptor antagonists, li-inhibitors tsa monoamine oxidase tse ke keng tsa fetoloa (MAO I), sulfonamides le lithethefatsi tse seng khahlanong le ts'oaetso tsa steroidal.

Lithethefatsi tse fokotsang Glyclazide MV

Ha e khothalletsoe hore e sebelisoe:

Tšebeliso e kopanetsoeng le danazol ha e khothalletsoe ka lebaka la kotsi ea ho eketseha ha tsoekere ea mali. Haeba ho sa khonehe ho hana tšebeliso ea danazol, joale hlalosetsa mokuli bohlokoa ba ho laola khatello ea mali maling le morong. Ka linako tse ling ho hlokahala hore u fetole tekanyetso ea Gliclazide MV nakong ea kalafo ea danazol le ka mor'a eona.

Mekhaako e hlokang ho ba hlokolosi:

Chlorpromazine ka tekanyetso e phahameng (tse fetang 100 mg ka letsatsi) e eketsa boemo ba tsoekere maling, e fokotsa sekhahla sa insulin.

Glucocorticosteroids (ts'ebetso ea kemiso le ea lehae: tsamaiso ea methapo, letlalo le tsamaiso ea methapo) le tetracosactrin e eketsa tsoekere ea mali ka nts'etsopele ea ketoacidosis, ka lebaka la phokotso ea mamello ea lik'habohaedreite ke glucocorticosteroids.

β2-adrenostimulants - ritodrin, salbutamol, terbutaline (ts'ebeliso ea methapo) e baka keketseho ea maemo a tsoekere.

Ela hloko ka ho khetheha bohlokoa ba ho itlhahloba tsoekere ea mali. Haeba ho hlokahala, fetisetsa mokuli kalafo ea insulin.

Haeba o hloka ho sebelisa metsoako e kaholimo, o hloka ho ela hloko ka ho khetheha ho laola maemo a tsoekere ea mali. Ho kanna ha hlokahala hore o kenye litekanyetso tsa MV Glyclazide ka bobeli nakong ea phekolo e kopaneng le ka mor'a ho khaotsa lithethefatsi tse ling.

Tsamaiso e kopaneng ea Gliclazide MV e nang le lithethefatsi tsa anticoagulant (warfarin, joalo-joalo) e ka lebisa ho eketseha ha phello ea anticoagulant ea lithethefatsi tse joalo. Ho ka 'na ha hlokahala hore u ntlafatse tokiso ea litheko tsa anticoagulant.

Tlhahisoleseling ka kakaretso

Setifikeiti sa ho ngolisa bakeng sa Gliclazide MV se fanoa ke k'hamphani ea Russia Atoll LLC. Lithethefatsi tlasa konteraka li hlahisoa ke k'hamphani ea meriana ea Samara Ozone. E hlahisa le ho beha lipilisi, 'me e laola boleng ba eona. Gliclazide MV e ke ke ea bitsoa meriana ea lapeng ka ho felletseng, kaha ho rekisoa setlhare sa litlhare bakeng sa eona (eona glyclazide) Chaena. Leha ho le joalo, ha ho letho le lebe le ka buuoang ka boleng ba moriana. Ho ea ka lefu la tsoekere, ha ho hobe ho feta lefu la tsoekere la Mofora ka sebopeho se tšoanang.

Kakaretso ea MV ka lebitso la moriana e bonts'a hore ntho e sebetsang ho eona e lokollotsoe, kapa e tsoetse pele, ho lokolla. Glyclazide e tsoa letlapeng ka nako e nepahetseng le sebakeng se nepahetseng, e netefatsang hore ha e kene maling a hang-hang, empa ka likarolo tse nyane. Ka lebaka lena, kotsi ea litlamorao tse sa rateheng e fokotsehile, moriana o ka nooa hangata.Haeba sebopeho sa letlapa le tlotsoa, ​​ketso ea lona ea nako e telele e lahlehile, ka hona, litaelo tsa tšebeliso ha e khothalletse ho e khaola.

Glyclazide e kenyelelitsoe lethathamong la meriana ea bohlokoa, ka hona, li-endocrinologists li na le monyetla oa ho fana ka tsona ho lefu la tsoekere mahala. Hangata, ho latela lengolo la ngaka, ke MV Gliclazide ea lapeng eo e leng analog ea Diabeteson ea mantlha.

Moriana o sebetsa joang?

Li-gliclazide tsohle tse tšoaretsoeng ka har'a tšilo ea lijo li kenella maling 'me moo li kopana le liprotheine tsa eona. Ka tloaelo, tsoekere e kenella liseleng tsa beta ebile e hlohlelletsa li-receptor tse ikhethang tse etsang hore insulin e tsoe. Glyclazide e sebetsa ka molao-motheo o tšoanang, e hlahisang ka botsitso li-synthesis tsa hormone.

Kameho ea tlhahiso ea insulin ha e felle feela ho phello ea MV Glyclazide. Setlhare se khona ho:

1. Fokotsa ho hanyetsa insulin. Liphetho tse ntle ka ho fetisisa (kutloelo-bohloko ea insulin ka 35%) li bonoa liseleng tsa mesifa.
2. Fokotsa motsoako oa tsoekere ke sebete, ka tsela eo, o lekanye ho potlaka ha eona.
3. Thibela mali.
4. Ho matlafatsa synthesis ea nitric oxide, e kenyelletsoang ho laola khatello, ho fokotsa ho ruruha, le ho ntlafatsa phepelo ea mali ho lithishu tse kenellang.
5. Sebetsa e le antioxidant.

Fomola foromo le litekanyetso

Letlapeng la Gliclazide MV ke 30 kapa 60 mg ea ntho e sebetsang. Lithako tse thusang ke: cellulose, e sebelisoang e le moemeli oa bulking, silica le magnesium stearate joalo ka emulsifiers. Matlapa a mmala o mosoeu kapa oa tranelate, o kentsoeng ka lithupa tsa likotoana tse 10-30. Ka pakete ea lilakane tse 2-3 (matlapa a 30 kapa a 60) le litaelo. Glyclazide MV 60 mg e ka aroloa ka halofo, hobane sena se na le kotsi matlapeng.

Setlhare se lokela ho nooa nakong ea lijo tsa hoseng. Gliclazide e sebetsa ho sa tsotelehe ho ba teng ha tsoekere maling. E le hore hypoglycemia e se ke ea etsahala, ha ho lijo tse lokelang ho ts'oaroa, e 'ngoe le e' ngoe ea tsona e lokela ho ba le palo e lekanang ea lik'habohaedreite. Ho eletsoa ho ja makhetlo a 6 ka letsatsi.

Melao ea khetho ea litekanyetso:

Litaelo tse qaqileng tsa tšebeliso

Ho latela likhothaletso tsa bongaka tsa Ministry of Health of the Russian Federation, gliclazide e lokela ho laeloa ho khothaletsa secretion ea insulin. Ka ho utloahalang, ho haella ha homone ea hau ho lokela ho netefatsoa ke ho hlahloba mokuli. Ho latela maikutlo, hangata sena ha se etsahale. Lingaka le li-endocrinologists li fana ka litlhare "ka leihlo". Ka lebaka leo, ho feta palo e hlokahalang ea insulin e patiloe, mokuli o lula a batla ho ja, boima ba hae bo ntse bo eketseha butle-butle, 'me matšeliso a lefu la tsoekere a lula a sa lekana. Ntle le moo, lisele tsa beta tse nang le mokhoa ona oa ts'ebetso li timetsoa ka potlako, ho bolelang hore lefu lena le ea mokhatlong o latelang.

Mokhoa oa ho qoba litlamorao tse joalo:

1. Qala ka tieo ho latela lijo tsa batho ba nang le lefu la tsoekere (tafoleng ea 9, palo e lumelletsoeng ea lik'habohaedreite e khethoa ke ngaka kapa mokuli ka boeena ho latela glycemia).
2. Kenyelletsa motsamao o mafolofolo tsamaisong ea letsatsi le letsatsi.
3. Fokotsa boima ba 'mele ho tloaelehileng. Mafura a mangata a mpefatsa lefu la tsoekere.
4. Ho nona glucophage kapa analogees ea eona. Sekhahla se nepahetseng ke 2000 mg.

Mme feela haeba mehato ena e sa lekana le tsoekere e tloaelehileng, o ka nahana ka gliclazide. Pele o qala kalafo, ho bohlokoa ho nka liteko tsa C-peptide kapa insulin ho etsa bonnete ba hore tlhahiso ea lihormone ha e na mathata.

Ha hemoglobin ea glycated e phahame ho feta 8,5%, MV Gliclazide e ka fuoa hammoho le lijo le metformin ka nakoana, ho fihlela lefu la tsoekere le buselitsoe. Kamora moo, taba ea ho khaotsa lithethefatsi e etsoa qeto ka bomong.

Setifikeiti sa ho ingolisa

JLLC "Lekpharm", Rephabliking ea Belarus, 223141, Logoysk, ul. Minskaya, 2a, tel / fekse: +375 1774 53 801, lengolo-tsoibila: [email protected]

Aterese ea mokhatlo e amohela likopo tsa bareki ka boleng ba sehlahisoa seterekeng sa Rephabliki ea Kazakhstan

Ofisi ea Moemeli oa Lekpharm COOO Rephabliking ea Kazakhstan,

050065, Rephaboliking ea Kazakhstan, Almaty, setereke sa Almaly, ul. Kazybek bi, d. 68/70, sekhutlo sa st. Nauryzbay batyr, tel. 8 (727) -2676670, fekse 8 (727) -2721178

Lebitso, aterese le lintlha tsa mohala

Ofisi ea Moemeli oa Lekpharm COOO Rephabliking ea Kazakhstan,

050065, Rephaboliking ea Kazakhstan, Almaty, setereke sa Almaly, ul. Kazybek bi, d. 68/70, sekhutlo sa st. Nauryzbay batyr, tel. 8 (727) -2676670, fekse 8 (727) -2721178,

Ketso ea pharmacological

Tlhahiso le kabo

Kamora ho kenya moriana kahare, gliclazide e kenelletse ka botlalo ho tsoa pampiring ea mala. Khetla ea gliclazide ho plasma e eketseha hanyane ka hanyane nakong ea lihora tsa pele tsa 6 kamora tsamaiso mme e fihla sehlabeng se phehellang ho tloha ka la 6 ho isa ho la 12. Phapang ea motho ka mong e tlaase haholo. Ho ja ha ho ame boemo ba ho monya. Boholo ba thepa bo ajoa ka lilithara tse 30. Plasma protein e tlamang ke hoo e ka bang 95%. Tekanyetso e le 'ngoe ea letsatsi le leng le le leng ea lithethefatsi Gliclada® e netefatsa hore ho boloka motsoako o sebetsang oa glyclazide ho plasma ea mali ka lihora tse fetang tse 24.

Gliclazide e tšelisoa haholo-holo ka har'a sebete. Li-metabolites tse hlahisoang ha li na mesebetsi ea meriana. Kamano pakeng tsa lethal dose e nkiloeng ho fihlela ho 120 mg le ts'oarelo ea lithethefatsi ho plasma ke ts'ehetso ea nako ka nako.

Nako ea halofo ea bophelo (T1 / 2) ea gliclazide ke lihora tse 12-20. E hloekisoa haholo ke liphio ka mokhoa oa metabolites, e ka tlase ho 1% e pepesitsoeng ka har'a moroto o sa fetohe.

Pharmacokinetics maemong a khethehileng a kliniki

Ho batho ba tsofetseng, ha ho liphetoho tse bonts'itsoeng maemong a bongaka a pharmacokinetic.

Gliclada® ke sethethefatsi se tsoang ka molomo se tsoang ho sehlopha sa sulfonylurea se tsoang molokong oa bobeli, se fapaneng le lithethefatsi tse tšoanang ka ho ba le selikalikoe se nang le heterocyclic sa N se nang le endocyclic bond.

Glyclada® e theola tsoekere ea mali ka ho susumetsa secretion ea "insulin" ke lihlekehleke tsa Langerhans tse nang le lisele tsa R. Kamora kalafo ea lilemo tse peli, keketseho ea boemo ba insulin ea secprandial le secretion ea C-peptides ea sala. Ho mofuta oa 2 lefu la tsoekere, lithethefatsi li khutlisa tlhoko ea pele ea "insulin secretion" ho arabela tšebeliso ea tsoekere le ho matlafatsa karolo ea bobeli ea seculin ea insulin. Keketseho e kholo ea secretion ea insulin e bonoa ho arabela ts'usumetso ka lebaka la ho ja lijo le tsamaiso ea tsoekere.

Ntle le ho ama metabolism ea carbohydrate, Glyclada® e na le phello ho microcirculation. Lithethefatsi li fokotsa kotsi ea thrombosis e nyane ea sekepe, e susumetsa mekhoa e 'meli e ka amehang ho nts'etsopele ea mathata a lefu la tsoekere: karohano e sa lekanyetsoang ea lintho tse kopanyang liplatelete le ho khomarela le ho fokotseha hoa khatello ea lintlha tsa ts'ebetso ea liplatelete (beta-thromboglobulin, thromboxane B2), hammoho le ho khutlisetsoa ha methapo ea methapo. vascular endothelial shughuli le tšebetso e eketsehang ea activator ea plasminogen.

U ka nka joang nakong ea kemaro

Litaelo tsa tšebeliso li thibela kalafo le Gliclazide nakong ea kemolo le ho lactation. Ho ea ka karohano ea FDA, sethethefatsi sena ke sa sehlopha sa C. Sena se bolela hore se ka ama hampe tsoelo-pele ea lesea, empa ha se bake liphapang tsa tlhaho ea setho. Gliclazide e sireletsehile ho nka sebaka sa kalafo ea "insulin" pele ho ima, maemong a feteletseng - qalong.

Monyetla oa ho anyesa le gliclazide ha o e-so hlahlojoe. Ho na le bopaki ba hore litokisetso tsa sulfonylurea li ka fetela lebese mme tsa baka hypoglycemia baneng, ka hona ts'ebeliso ea bona nakong ena e thibetsoe ka thata.

Ngaka ea Saense ea Bongaka, Hlooho ea Setsi sa Lefapha la Diabetes - Tatyana Yakovleva

Ke qetile lilemo tse ngata ke ithuta lefu la tsoekere. Hoa tšosa ha batho ba bangata ba shoa, mme le ho feta ba holofala ka lebaka la lefu la tsoekere.

Ke potlakela ho bolela litaba tse molemo - Setsi sa Patlisiso ea Endocrinological sa Russian Academy of Medical Science se atlehile ho hlahisa moriana o folisang lefu la tsoekere ka botlalo. Hona joale, katleho ea sethethefatsi sena e atametse 98%.

Litaba tse ling tse monate: Lekala la Bophelo le se le iphumanetse tšebetso ea lenaneo le ikhethileng bakeng sa litšenyehelo tse phahameng tsa lithethefatsi. Naheng ea Russia, ba lefu la tsoekere HO fihlela ka la 18 Motšeanong (ho kenyeletsoa) ka e fumana - Bakeng sa li-ruble tse 147 feela!

Litla-morao le ho sebelisa overdose haholo

Litlamorao tse mpe ka ho fetisisa tsa MV Glyclazide ke hypoglycemia. E etsahala ha tlhahiso ea insulin e fetile tlhoko ea eona. Lebaka e ka ba tšebeliso e feteletseng ea lithethefatsi ka tšohanyetso, ho tlōla lijo kapa ho haelloa ke lik'habohaedreite ho eona, esita le ho ikoetlisa ka ho feteletseng. Hape, ho theoha ha tsoekere ho ka baka ho bokellana ha gliclazide maling ka lebaka la ho fokola ha masapo le sebete, keketseho ea ketsahalo ea insulin mafu a mang a endocrine. Ho latela maikutlo, kalafo ea sulfonylureas e nang le hypoglycemia, hoo e batlang e le lefu la tsoekere kaofela. Bongata ba tsoekere bo ka felisoa mothating o bonolo.

Ha e le molao, hypoglycemia e tsamaisana le matšoao a tšobotsi: tlala e matla, ho thothomela ha liphello, ho ruruha, bofokoli. Bakuli ba bang butle-butle ba khaotsa ho utloa matšoao ana, ho theoha ha tsoekere ho sokela bophelo. Ba hloka taolo ea tsoekere khafetsa, ho kenyelletsa bosiu, kapa ho fetisoa matlapeng a mang a theolang tsoekere a se nang litlamorao tse joalo.

Kotsi ea liketso tse ling tse sa batleheng tsa Gliclazide e hlahlojoa e le e sa tloaelehang ebile e le seoelo. Ho ka etsahala:

• Mathata a amanang le tšilo ea lijo ka tsela ea ho nyekeloa ke pelo, ho sisinyeha ha mmele ka thata, kapa lets'ollo. U ka li fokotsa ka ho nka Glyclazide nakong ea lijo tse matlafatsang ka ho fetisisa,
• allergies ea letlalo, hangata e le ka mokhoa oa lekhopho le tsamaeang le ho hlohlona,
• ho fokotseha ha liplatelese, lisele tse khubelu tsa mali, lisele tse tšoeu tsa mali. Motsoako oa mali o khutlela ho a le mong ka mor'a ho felisoa ha Gliclazide,
• keketseho ea nakoana ea tšebetso ea li-enzyme tsa sebete.

Ho Glyclazide MV e kentsoe khang

Ke eng e ka nkeloang

Gliclazide ea Russia ha e theko e phahameng, empa ho e-na le moriana oa boemo bo holimo, theko ea ho kenya Gliclazide MV (30 mg, 60 unit) e fihla ho li-ruble tse 150. Pheta hape ka li-analogues ha feela matlapa a tloaelehileng a sa rekisoe.

Lithethefatsi tsa pele ke Diabeteson MV, lithethefatsi tse ling tsohle tse nang le sebopeho se le seng, ho kenyeletsoa Gliclazide MV ke li-generics, kapa likopi. Theko ea lefu la tsoekere e batla e le makhetlo a 2-3 ho feta lihlahisoa tsa eona tsa tlhaho.

Gliclazide MV analogues le bathusi ba ngolisitseng ho Russian Federation (ho bontšitsoe feela litokisetso tse lokisitsoeng tsa tokollo):

• Glyclazide-SZ e hlahisoang ke Severnaya Zvezda CJSC,
• Golda MV, Pharmasintez-Tyumen,
• Gliclazide Canon e tsoang Canonpharm Production,
• Glyclazide MV Apotheken, Apotekkhimfarm,
• Diabetalong, moetsi oa MS-Vita,
• Gliklada, Krka,
• Glidiab MV from Akrikhin,
• Tlhahiso ea Diabefarm MV Pharmacor.

Theko ea li-analogues ke li-ruble tse 120-150 ka sephutheloana. Gliklada e entsoeng ka Slovenia ke sethethefatsi se theko e boima ho feta lethathamong lena, pakete e bitsa li-ruble tse 250.

Litlhahlobo tsa lefu la tsoekere

Ke balile hore Galvus e fana ka phello e tšoanang, empa e sireletsehile haholo ho latela ho theoha ha tsoekere ka sekhahla. Ke tla kopa ngaka ho e nkela Gliclazide.

Etsa bonnete ba hore o ithuta! Na u nahana hore ho sebelisa lipilisi le insulin ka nako e telele ke eona feela tsela ea ho boloka tsoekere e le taolong? Ha se nnete! U ka netefatsa sena ka ho qala ho e sebelisa. bala haholoanyane >>