Hypothiazide: litaelo tsa tšebeliso

Sehloohong sena, o ka bala litaelo tsa ho sebelisa lithethefatsi Hypothiazide. E fana ka maikutlo a tsoang ho baeti sebakeng sena - bareki ba meriana ena, hammoho le maikutlo a litsebi tsa bongaka mabapi le tšebeliso ea Hypothiazide ts'ebetsong ea bona. Kopo e kholo ke ho kenyelletsa litlhatlhobo tsa hau ka matla mabapi le diuretic: moriana o thusitseng kapa o sa thusa ho felisa lefu lena, hore na ho na le mathata afe le afe, mme mohlomong a sa phatlalatsoe ke moetsi ho phatlalatso. Hypothiazide analogues moo ho nang le li-analogues tsa sebopeho tse fumanehang. Sebelisa bakeng sa kalafo ea khatello ea methapo ea methapo le lefu la methapo ho batho ba baholo, bana, esita le nakong ea kemaro le ho beleha.

Hypothiazide - diuretic (diuretic). Mokhoa o ka sehloohong oa ts'ebetso ea thiazide diuretics ke ho eketsa diuresis ka ho thibela ho ts'oaroa ha sabsorption ea sodium le chionine ion karolong ea pele ea li-renal tubules. Sena se lebisa ho eketsehileng extretion ea sodium le chlorine mme, ka hona, metsi. Mofuta oa li-electrolyte tse ling, e leng potasiamo le magnesium, le ona oa eketseha. Ka tekanyetso e phahameng ea kalafo, phello ea diuretic / natriuretic ea thiazides kaofela e batla e tšoana.

Natriuresis le diuresis li etsahala ka nako ea lihora tse 2 mme li fihla boemong bo phahameng kamora lihora tse ka bang 4.

Li-Thiazides li boetse li fokotsa tšebetso ea li-anidrase tsa carbonic ka ho eketsa li-ion tsa bicarbonate, empa hangata phello ena ha e na matla ebile ha e ame pH ea moroto.

Hydrochlorothiazide (ntho e sebetsang ea lithethefatsi Hypothiazide) le eona e na le thepa ea antihypertensive. Liuretics tsa Thiazide ha li ame khatello e tloaelehileng ea mali.

Sebopeho

Hydrochlorothiazide + excipients.

Mofumahali

Hypothiazide ha e-ea lekana, empa e kenella ka potlako ho tsoa ho tšilo ea lijo. Matla ana a phehella lihora tse 6 ho isa ho tse 6. Hydrochlorothiazide e tšela sethala sa placental mme e tšeloa ka lebese la matsoele. Mokhoa o ka sehloohong oa boits'oaro ke liphio (filtration le secretion) ka sebopeho se sa fetoheng.

Matšoao

• khatello ea methapo ea kutlo (ka bobeli bakeng sa monotherapy le hammoho le lithethefatsi tse ling tsa antihypertensive),
• edema syndrome ea methapo e fapaneng (ho sa feleng ha pelo ho sa feleng, lefu la nephrotic, khatello ea maikutlo ea khatello ea maikutlo, glomerulonephritis, ho se sebetse hantle ha renal, phallo ea methapo ea pelo, kalafo ka corticosteroids),
• taolo ea polyuria, haholoholo le lefu la tsoekere la nephrogen,
• thibelo ea sebopeho sa majoe ka har'a pilara ea urine ho bakuli ba qhekelloang (hypercalciuria e fokotsehileng).

Lokolla liforomo

Matlapa a 25 mg le 100 mg.

Litaelo tsa tšebeliso le litekanyetso

Tekanyetso e lokela ho khethoa ka bonngoe. Ka ho beha leihlo khafetsa bongaka, ho thehoa lethal dose le sebetsang. Moriana o lokela ho nooa ka molomo ka mor'a lijo.

Ka khatello ea mali ea methapo, lethal dose la pele ke 25-50 mg ka letsatsi hang, ka mokhoa oa monotherapy kapa hammoho le mahlahana a mang a antihypertgency. Bakeng sa bakuli ba bang, tekanyetso ea pele ea 12,5 mg e lekane (ka bobeli e le monotherapy hape e kopane). Hoa hlokahala ho sebelisa tekanyetso e sebetsang e tlase, e sa feteng 100 mg ka letsatsi. Ha u kopanya hypothiazide le lithethefatsi tse ling tsa antihypertensive, ho ka hlokahala hore u theole tekanyetso ea lithethefatsi tse ling ho thibela ho fokotseha ho feteletseng ha khatello ea mali.

Matla a antihypertensive a bonahala matsatsing a 3-4, empa ho ka nka libeke tse 3-4 ho fihlela sephetho se nepahetseng. Kamora ho fela ha phekolo, phello ea hypotensive e phehella beke e le 'ngoe.

Ka lefu la edematous la tlhaho e fapaneng, lethal dose la pele ke 25-100 mg ka letsatsi hang kapa ka nako e le ngoe ka matsatsi a mabeli. Ho latela karabelo ea bongaka, tekanyo e kanna ea fokotsoa ho 25-50 mg ka letsatsi hang kapa ka matsatsi a mabeli. Maemong a mang a boima, qalong ea kalafo, keketseho ea tekanyetso ea moriana ho ea ho 200 mg ka letsatsi e ka hlokahala.

Ka lefu la tsitsipano ea premenstrual, moriana o laetsoe ka tekanyetso ea 25 mg ka letsatsi mme o sebelisoa ho tloha qalong ea matšoao ho isa ho qala ho ea khoeling.

Ka insipidus ea lefu la tsoekere la nephrogenic, ho khothalletsoa tekanyetso e tloaelehileng ea letsatsi le letsatsi ea 50-150 mg (litekanyetso tse 'maloa).

Ka lebaka la tahlehelo e ntseng e eketseha ea potasiamo le ion ea magnesium nakong ea kalafo (maemo a potasiamo ea serum a ka ba joalo

Ketso ea pharmacological

Phello ea diuretic ea hydrochlorothiazide ke eona e ikarabellang bakeng sa thibelo e tobileng ea ho khutlisetsoa ha Na + le SG ka har'a li-distal tubules. Tlas'a tšusumetso ea eona, excretion ea Na + le SG e matlafatsoa mme, ka lebaka la sena, likhakanyo tsa metsi, hammoho le potasiamo le magnesium. Phello ea diuretic ea hydrochlorothiazide e fokotsa bongata ba potoloho ea plasma, e eketsa ts'ebetso ea plasma renin, e ntlafatsa tlhahiso ea aldosterone, ka lebaka leo tlhahiso ea potasiamo le bicarbonate mochineng o eketsehang le khatello ea potasiamo e serum e fokotseha. Angiotensin-P e laola tlamo ea renin-aldosterone, ka hona, ts'ebeliso e kopaneng ea angiotensin-P receptor antagonist e ka khutlisa ts'ebetso ea potasiamo ea potasiamo e amanang le thiazide diuretic.

Setlhare se na le phello e fokolang ea thibelo ho carbonic anhydrase, ho isa tekanyong e lekanang, ka hona e ntlafatsa secretion ea bicarbonate, leha ho se na phetoho e kholo ho moriana oa pine.

Mofumahali

Hydrochlorothiazide e kenella hantle kamora ho tsamaisoa ka molomo, litlamorao tsa eona tsa diuretic le natriuretic li etsahala ka nako ea lihora tse 2 kamora taolo mme li fihlella boholo ba tsona kamora lihora tse ka bang 4. Ketso ena e tšoarella ho 6-12

E pepesitsoe ka liphio ka sebopeho se sa fetoheng. Bophelo ba halofo bakeng sa bakuli ba nang le ts'ebetso e tloaelehileng ea renal ke lihora tse 6.4, bakeng sa bakuli ba nang le ho hlaphoheloa ha methapo e itekanetseng - lihora tse 11.5, le bakeng sa ho hloleha ho matla ha renal ka tumello ea creatinine tlase ho 30 ml / min. - lihora tse 20,7. Hydrochlorothiazide e tšela sethala sa placental mme e tšeloa ka lebese la matsoele ka bongata bo fokolang.

Matšoao a ho sebelisoa

• Hypertension (ka mefuta e bonolo - ka bobeli ka mokhoa oa monotherapy, le hammoho le lithethefatsi tse ling tsa antihypertensive).

• Edema ea pelo, hepatic kapa renal etiology, premenstrual edema, edema e tsamaeang le pharmacotherapy, joalo ka corticosteroid.

• Ka lefu la tsoekere la nephrogenic ho fokotsa polyuria (phello ea paradoxical)

• Ho fokotsa hypercalciuria.

Contraindication

• Hypersensitivity ho lithethefatsi kapa li-sulfonamide tse ling

• Phekolo e matla (tumello ea creatinine ka tlase ho 30 ml / min) kapa ho hloleha ha sebete

• Ho hana ho phekola hypokalemia kapa hypercalcemia

• Matšoao a tšoaetso ea kelello (gout)

Moriana ha o bontšoa hore o ka sebelisoa baneng ba ka tlase ho lilemo tse 6.

Bokhachane le pelehi

Boiphihlelo ba nang le hydrochlorothiazide nakong ea kemolo, haholo-holo ho trimester ea pele, e na le moeli. Lintlha tse fumanoeng litekong tsa liphoofolo ha lia lekana. Hydrochlorothiazide e tšela sethala sa placental. Haeba hydrochlorothiazide e sebelisoa ho trimester ea bobeli le ea boraro, eona (ka lebaka la ts'ebetso ea eona ea bongaka) e ka senya botenya ba fetoplacental mme ea baka jaundice ea lesea kapa e sa tsoa hlaha, ho se leka-lekane ha electrolyte le thrombocytopenia.

Hydrochlorothiazide ha ea lokela ho sebelisoa nakong ea bokhachane ho phekola edema, khatello ea mali kapa preeclampia, hobane ho fapana le ho ba le phello e ntle ho lefu lena, e eketsa tšoso ea ho fokotseha ha molumo oa plasma le tšoso ea phallo ea mali e sa sebetseng ho popelo le placenta.

Hydrochlorothiazide e ke ke ea sebelisoa ho phekola khatello ea maikutlo e bohlokoa ho basali ba bakhachane, ntle le maemong a sa tloaelehang ha kalafo e meng e sa sebelisoe.

Matlapa a Hydrochlorothiazide ha a lokela ho sebelisoa nakong ea kemolo - a ka sebelisoa feela maemong a thehiloeng hantle.

Hydrochlorothiazide e fetela lebese la matsoele; tšebeliso ea eona e hanyetsoa nakong ea ho anyesa. Haeba ts'ebeliso ea eona e sa khonehe, ho anyesa ho lokela ho emisoa.

Tekanyetso le tsamaiso

Litekanyetso li lokela ho khethoa ka bonngoe 'me li hloka tlhokomelo ea kamehla ea bongaka. Ka lebaka la tahlehelo e eketsehang ea potasiamo le magnesium nakong ea kalafo (boemo ba potasiamo ea serum bo ka theoha ka tlase ho 3.0 mmol / l), ho na le tlhokeho ea ho khutlisoa ha potasiamo le magnesium. Tlhokomelo e khethehileng e lokela ho nkoa ho bakuli ba nang le ho nyekeloa ke pelo, bakuli ba nang le ts'ebetso ea sebete e sa foleng, kapa ho bakuli ba fumanang kalafo ea digitalis glycoside. Matlapa a lokela ho nooa kamora lijo.

Joaloka moemeli oa antihypertgency, tekanyetso e tloaelehileng ea letsatsi le letsatsi ke 25-100 mg ka tekanyetso e le 'ngoe, ka mokhoa oa monotherapy kapa hammoho le lithethefatsi tse ling tsa antihypertensive. Bakeng sa bakuli ba bang, tekanyetso ea pele ea 12,5 mg e lekane, ka bobeli ka mokhoa oa monotherapy le ka kopanelo. Hoa hlokahala ho sebelisa tekanyetso e sebetsang e sa feteng 100 mg ka letsatsi. Haeba hypothiazide e kopantsoe le lithethefatsi tse ling tsa antihypertensive, ho ka hlokahala hore u theole litekanyetso tsa lithethefatsi ka bomong ho thibela ho theoha ha khatello ea mali haholo.

Tšusumetso ea antihypertensive e bonahala matsatsing a 3-4, leha ho le joalo, e kanna ea nka libeke tse 3-4 ho fihlela sephetho se nepahetseng. Kamora kalafo, phello e matlafatsang e phehella ho fihlela beke.

Ka kalafo ea edema tekanyetso e tloaelehileng ea ho qala ke 25-100 mg ea moriana hang ka letsatsi kapa hanngoe ka matsatsi a mabeli. Ho latela karabelo ea bongaka, lethal dose e lokela ho fokotsoa ho 25-50 mg hang ka letsatsi kapa hanngoe ka matsatsi a mabeli. Maemong a mang a matla, ho ka 'na ha hlokahala tekanyetso ea pele ea 200 mg ka letsatsi.

Ho edema ea premenstrual, lethal dose le tloaelehileng ke 25 mg ka letsatsi 'me le sebelisoa ho tloha qalong ea matšoao ho isa ho qala ho ea khoeling.

Ka lefu la tsoekere la nephrogenic Ho khothalletsoa tekanyetso e tloaelehileng ea letsatsi le letsatsi ea 50-150 mg (ka litekanyetso tse 'maloa).

Methapo e lokela ho thehoa ho latela boima ba ngoana. Litekanyetso tse tloaelehileng tsa letsatsi le letsatsi tsa bana, 1-2 mg / kg ea boima ba 'mele kapa 30-60 mg ka halofo ea mithara ka bophara ba mmele, li fanoa hang ka letsatsi. Tekanyetso ea letsatsi le letsatsi bakeng sa bana ba lilemo tse 6 ho isa ho 12 ke 37,5-100 mg ka letsatsi.

Bongata

Letsetsa ngaka ea hau kapa kamore ea maemo a tšohanyetso hanghang haeba u sebelisa lithethefatsi tse ngata tse feteletseng!

Ponahatso e hlakileng ka ho fetisisa ea chefo ea hydrochlorothiazide ke tahlehelo e matla ea mokelikeli le li-electrolyte, tse hlahisitsoeng ka lipontšo le matšoao a latelang:

Phello ea pelo: Tachycardia, hypotension, makala

Neuromuscular: bofokoli, pherekano, ho tsekela le ho ts'oaroa ke mesifa, paresthesia, ho hloka kelello, mokhathala.

Ka mpeng: ho nyekeloa, ho hlatsa, lenyora,

Lenane: polyuria, oliguria kapa anuria.

Matšoao a laboratori - hypokalemia, hyponatremia, hypochloremia, alkalosis, maemo a phahameng a naetrojene maling (haholo-holo ho bakuli ba nang le bothata ba ho phekoloa ke lefu la masapo).

Phekolo ea bongoana:

Ho qala ho hlatsa, ho hlatsoetsoa ka mpeng e ka ba litsela tsa ho pepesetsa lithethefatsi. Ho monya ha moriana ho ka fokotsoa ka ho sebelisa khabone e hlahisitsoeng. Tabeng ea hypotension kapa ho thothomela, bophahamo ba potoloho ea plasma le li-electrolyte (potasiamo, sodium, magnesium) li lokela ho lefelloa.

Tekanyo ea-electrolyte ea metsi (haholo-holo maemo a serum potasiamo) le ts'ebetso ea liphio li lokela ho hlahlojoa ho fihlela boleng bo tloaelehileng bo thehiloe.

Ho sebelisana le lithethefatsi tse ling

Etsa bonnete ba hore u tsebisa mofani oa litsebeletso tsa hau tsa bophelo bo botle ka meriana eohle eo u e nkang, le haeba e ka etsahala.

Mohlomong tšebelisano lipakeng tsa thiazide diuretics le lithethefatsi tse latelang ka tšebeliso ea tsona e tšoanang.

Tai, barbiturates, lithibela-mafu kapa lithibela-mafu:

E ka ntlafatsa hypotension ea orthostatic.

Li-antidiabetesic agents (ka molomo le ka insulin):

Phekolo ea Thiazide e ka fokotsa mamello ea tsoekere. U kanna ua hloka ho fetola tekanyetso ea lithethefatsi tsa hypoglycemic. Metformin e lokela ho sebelisoa ka hloko ka lebaka la kotsi ea lactic acidosis ka lebaka la ts'ebetso ea ho hlaphoheloa ha renal e amanang le hydrochlorothiazide.

Lirosa tse ling tsa antihypertgency:

Colestyramine le li-resini tsa colestipol:

Boteng ba li-resin tsa phapanyetsano ea anion, ho monya ha hydrochlorothiazide ho tsoa ho tšilo ea lijo ho senyehile. Tekanyetso e le 'ngoe ea li-colestyramine kapa li-colestipole resins e tlatsa hydrochlorothiazide mme e fokotsa ho monya ha eona ka mpeng ea gastric, ka ho latellana, ka 85% le 43%.

Mechine ea Pressor (mohlala, adrenaline):

Ho ka etsahala hore ketso ea li-amine tsa khatello li fokotsoe, empa eseng joalo ka mokhoa o thibelang ts'ebeliso ea bona.

Boikhathollo ba mesifa e sa nyenyefatseng (mohlala, tubocurarine):

Matla a ho phomotsa mesifa a ka eketseha.

Li-diuretics li fokotsa ho pepeseha hoa lithium mme li eketsa kotsi ea litlamorao tsa lithium. Tšebeliso ea bona ka nako e ts'oanang ha e khothalletsoe. Meriana ea kalafo ea gout (probenicid, sulfinpyrazone le allopurinol):

Ho ka hlokahala tokiso ea tekanyetso ea li-uricosuric agents, hobane hydrochlorothiazide e ka eketsa maemo a serum uric acid. Keketseho ea tekanyetso ea probenidal kapa sulfinpyrazone e kanna ea hlokahala. Tšebeliso e ts'oanang ea li-thiazides e ka eketsa khafetsa ea maikutlo a hypersensitivity ho allopurinol.

Anticholinergics (mohlala, atropine, biperiden):

Ka lebaka la ho fokotseha ha sepheo sa tšubuhlellano ea ka mpeng le boemo ba sefuba bo felisang, bioavailability ea diuretic ea mofuta oa thiazide ea eketseha.

Li-agents tsa Cytotoxic (mohlala, cyclophosphamide, methotrexate):

Li-Thiazides li ka fokotsa phello ea renal ea lithethefatsi tsa cytotoxic le ho matlafatsa phello ea tsona ea myelosuppressive.

Sebakeng sa litekanyetso tse phahameng tsa salicylates, hydrochlorothiazide e ka ntlafatsa phello e chefo ea li-salicylates tsamaisong ea methapo e bohareng.

Maemong a mang, anemia ea hemolytic e ile ea tlalehoa ka tšebeliso e tšoanang ea hydrochlorothiazide le methyldopa.

Tšebeliso e kopanetsoeng le cyclosporine e ka eketsa hyperuricemia le kotsi ea ho ba le mathata a kang gout.

Hypokalemia kapa hypomagnesemia e hlahisoang ke thiazide e ka kenya letsoho kholisong ea arrhythmias e hlahisoang ke dijithale.

Meriana e anngoeng ke liphetoho tsa serum potasiamo:

Boikemisetso ba nako le nako ba litekanyetso tsa serum potasiamo le ho hatisoa ha electrocardiogram ho khothalletsoa haeba hydrochlorothiazide e sebelisoa ka mokhoa o ts'oanang le lithethefatsi tse amangoang ke liphetoho litlamong tsa serum potasiamo (mohlala, glycosides le lithethefatsi tsa antiarrhythmic), hammoho le lithethefatsi tse latelang tsa pirouette-mofuta tachycardia (ventricular tachycardia) (ho kenyeletsoa le lithethefatsi tse ling tsa antiarrhythmic), hobane hypokalemia ke eona e tlatsetsang ho ntlafatso ea tachycardia e kang pirouette:

• lithethefatsi tsa antiarrhythmic tsa sehlopha sa 1a (mohlala, quinidine, hydroquinidine, disopyramide),

• lithethefatsi tsa sehlopha sa antiarrhythmic tsa sehlopha sa III (mohlala, amiodarone, sotalol, dofetilide, ibutilide),

• li-antipsychotic tse ling (mohlala, thioridazine, chlorpromazine, levomepromazine, trifluoperazin, cyamemazine, sulpiride, sultopride, amisulpride, tiapride, pimozide, haloperidol, droperidol),

• meriana e meng (mohlala, bepridil, cisapride, diphemanil, intravenous erythromycin, halofantrine, misolastine, pentamidine, terfenadine, vincamine ea methapo).

Liazardide diuretics li eketsa maemo a calcium ea serum ka lebaka la phallo e tlotsitsoeng. Haeba ho na le tlhoko ea ho khethoa ha li-agents tse khutlisang sethala sa calcium, ho hlokahala ho laola boemo ba calcium ka serum mme, ho latela eona, khetha tekanyo ea calcium.

Tšebelisano lipakeng tsa lithethefatsi le liteko tsa laboratori: Ka lebaka la phello ea metabolism ea calcium, thiazides e ka sotha litholoana tsa liteko tsa ts'ebetso ea parathyroid

Likarolo tsa ts'ebeliso

Tlhahlobo ea bongaka le ea baeloji ea hlokahala ka lebaka la kotsi ea hyponatremia ea matšoao.

Iodine e nang le li-iodine tse fapaneng:

Maemong a ho felloa ke metsi 'meleng ho bakoang ke diuretics, menyetla ea ho hloleha ho hlaba a hlaba haholo e eketseha, haholo ha ho sebelisoa litekanyetso tse phahameng tsa iodine e nang le iodine. Pele u sebelisa iodine, ho bohlokoa ho pheta mokelikeli 'meleng oa bakuli.

Amphotericin B (parenteral), corticosteroids, ACTH le li-laxatives tse hlasimollang:

Hydrochlorothiazide e ka kenya letsoho ho se lekane ha electrolyte, haholoholo nts'etsopele ea hypokalemia.

Sokolla foromo le sebopeho

Sebopeho sa litekanyetso: matlapa a pota-potile, a sephara, 'me a na le mohala o arolang lehlakoreng le leng' me o ngotsoe "H" ka lehlakoreng le leng, o mosoeu kapa o batla o soeufetse (li-pcs tse 20. Ka lisilinki, ka lebokoseng la 1 blister le litaelo tsa tšebeliso ea Hypothiazide.

Motsoako o sebetsang ke hydrochlorothiazide, litaba tsa teng ka har'a letlapa le le leng ke 25 kapa 100 mg.

Likarolo tse thusang: gelatin, magnesium stearate, starch ea poone, talc, lactose monohydrate.

Mofumahali

Karolo e sebetsang ea Hypothiazide ke thiazide diuretic hydrochlorothiazide, mochini o sebetsang oa ts'ebetso oa ona ke ho eketsa diuresis ka ho thibela ho ts'oaroa ha sabsorption ea sodium le chlorine ion karolong ea pele ea li-renal tubules. Ka lebaka leo, excretion ea sodium, chlorine, 'me, ka hona, metsi a eketseha. Ntle le moo, tlhahiso ea li-electrolyte tse ling - potasiamo le magnesium - e ntse e hola. The diuretic / natriuretic phello ea li-thiazides tsohle ha e nkuoa ka tekanyetso e phahameng ea kalafo e batla e tšoana.

Ketso ea Natriuretic le phello ea diuretic li etsahala ka lihora tse 2, li fihle boemong bo phahameng kamora lihora tse ka bang 4.

Thiazide diuretics, ho feta moo, ka ho eketsa lits'oants'o tsa li-ion tsa bicarbonate li fokotsa ts'ebetso ea khalase ea carbonic, empa hangata phello ena e hlahisoa ka mokhoa o fokolang mme ha e ame pH ea moroto.

Hydrochlorothiazide e na le thepa ea antihypertensive. Liazure diuretics ha li ame khatello e tloaelehileng ea mali (BP).

Hypothiazide, litaelo tsa tšebeliso: mokhoa le litekanyetso

Matlapa a Hypothiazide a nooa ka molomo ka mor'a lijo.

Tekanyetso e khethoa ka bonngoe nakong ea kalafo. Ha a hlahloba boemo ba bongaka ba mokuli, ngaka e fana ka tekanyetso e sebetsang ea hypothiazide.

Dosing ea mantlha ea batho ba baholo:

• Edematous syndrome ea li-etiologies tse fapaneng: 25-100 mg 1 nako ka letsatsi kapa nako e le ngoe ka matsatsi a 2, maemong a matla - 200 mg ka letsatsi. Ha ho fanoa ka maikutlo a bongaka, ho ka khonahala ho fokotsa tekanyetso ho 25-50 mg ka letsatsi hang kapa ka matsatsi a mabeli,
• Matšoao a khatello ea maikutlo pele ho nako: 25 mg hang ka letsatsi, tsamaiso e qala ho tloha ha matšoao a pele a hlaha pele ho ho ilela khoeli,
• Arterial hypertension (e kopantsoeng le monotherapy): 25-50 mg hang ka letsatsi, ho bakuli ba bang 12,5 mg e lekane. Tekanyetso e sebetsang e fokolang ha ea lokela ho feta 100 mg ka letsatsi. Phello ea kalafo e bonahala matsatsing a 3-4, bakeng sa botsitso bo nepahetseng ba khatello ea mali (BP) e kanna ea nka libeke tse 3-4. Kamora ho tlosoa ha hypothiazide, phello ea hypotensive e lula beke e le 'ngoe. Ho thibela ho fokotseha ho matla ha khatello ea mali nakong ea phekolo e kopaneng, ho ka hlokahala ho fokotsa tekanyetso ea li-antihypertgency agents.
• Nephrogenic lefu la tsoekere insipidus: 50-150 mg ka letsatsi ho litekanyetso tse 'maloa.

Tekanyetso ea Hypothiazide bakeng sa bana e baloa ho nahanela boima ba ngoana. Pilisi ea letsatsi le letsatsi ea bana hangata e le 1-2 mg ka boima ba 1 kg ya boima ba ngoana kapa 30-60 mg ka mitha e le 'ngoe. bokaholimo ba mmele 1 nako ka letsatsi, bakeng sa bana ba lilemo li 3 ho isa ho 12 - 37,5-100 mg ka letsatsi.

Litlamorao

Tšebeliso ea hypothiazide e ka baka litlamorao tse latelang:

• Ts'ebetso ea ho ja: ho ipolaisa tlala, lets'ollo kapa ho sokela, cholecystitis, jaundice ea cholestatic, pancreatitis, sialadenitis,
• Metabolism: ts'oaetso, ho ferekanya, ho lieha ho nahana, ho tsitsipana, ho teneha, mokhathala, mesifa ea mesifa mokokotlong oa hypercalcemia, hypomagnesemia, hypokalemia, hyponatremia. Morethetho o sa tloaelehang oa pelo, molomo o omeletseng, lenyora, mokhathala o sa tloaelehang kapa ho fokola, ho fetoha ha psyche kapa ho ferekana, ho nyekeloa le mesifa, ho nyekeloa ke pelo, ho hlatsa ka lebaka la alkalosis ea hypochloremic (ka ntle ho moo, hypochloremic alkalosis e ka baka hepatic encephalopathy kapa komello). Glycosuria, hyperuricemia ka nts'etsopele ea tlhaselo ea gout. Hyperglycemia, e ka bakang nts'etsopele ea lefu la tsoekere la khale la khale. Phekolo ea chai e phahameng e ka eketsa li-serum lipids,
• Sistimi ea pelo: arrhythmia, vasculitis, hypthension ea orthostatic,
• Sistimi ea Hematopoietic: Haholo - thrombocytopenia, leukopenia, hemolytic anemia, agranulocytosis, anemia ea aplasiki,
• Mokhoa oa tsamaiso ea methapo: Pono e lerootho ea nakoana, hlooho e bohloko, ho tsekela, paresthesia,
• Sistimi ea urinary: ho kena-kenana ha leihlo, ho senyeha hoa liphio,
• Litlamorao: urticaria, photosensitivity, necrotic vasculitis, purpura, Stevens-Johnson syndrome, karabelo ea anaphylactic ho fihlela ho makala. Letšoao la khatello ea maikutlo le amang pneumonitis le edema e se nang cardiogenic pulmonary edema,
• Tse ling: potency e fokotsehile.

Litaelo tse khethehileng

Nakong ea kalafo ea nako e telele, ho a hlokahala ho laola matšoao a kalafo ea ho leka-lekana ea motlakase oa metsi, haholo ho bakuli ba nang le ts'ebetso ea sebete, mafu a methapo ea pelo.

Ts'ebeliso ea hypothiazide e khothalletsa ntlafatso e ntlafalitsoeng ea ion ea magnesium le potasiamo, ka hona, ho tsamaisana le ts'ebetso ea kalafo, mehato e tlameha ho nkuoa ho felisa khaello ea bona.

Bakeng sa bakuli ba nang le ts'ebetso ea renal e sa sebetseng hantle, tumello ea creatinine e lokela ho beoa leihlo ka mokhoa o hlophisehileng; maemong a oliguria, potso ea ho tlohela hypothiazide e lokela ho arajoa.

Bakeng sa bakuli ba nang le ts'ebetso ea sebete e sa sebetseng, li-thiazides li lokela ho sebelisoa ka hloko, hobane liphetoho tse nyane tekong ea li-electrolyte le li-serum ammonia li ka baka ho hepatic coma.

Ts'ebeliso ea hypothiazide ho bakuli ba nang le "coronary" le "cerebral" sclerosis e matla haholo e hloka tlhokomelo e khethehileng.

Phekolo ea nako e telele bakeng sa mellitus ea morao-rao le e bonahatsang tsoekere e tlameha ho tsamaisana le ho shebella ka tatellano metabolism ea carbohydrate le tokiso ea litekanyetso tsa lithethefatsi tsa hypoglycemic.

Tlhahlobo ea kamehla ea boemo bona e hloka bakuli ba nang le metabolite ea uric acid e senyehileng.

Phekolo ea nako e telele, maemong a sa tloaelehang, e ka lebisa phetohong ea pathological litšoelesa tsa parathyroid.

Bokhachane le pelehi

Hydrochlorothiazide e feta sethaleng sa placental, ka hona ho na le kotsi ea bokhachane / jaundice e sa tsoa tsoaloa, thrombocytopenia, le lintho tse ling tse mpe tse fapaneng.

Ts'ebeliso ea hypothiazide ho "trimester" ea pele ea kemaro e tiisitsoe ka molao. Ho li-trimesters tsa II - III, moriana o beoa feela ha ho hlokahala, ha phaello e lebelletsoeng ho mme e phahame ho feta kotsi e ka bang teng ho lesea.

Hydrochlorothiazide e epolloa ka ho lactation ka lebese la matsoele. Haeba u hloka ho e sebelisa nakong ena, o lokela ho emisa ho anyesa.

Sebopeho le mofuta oa tokollo

ka har'a blister 20 likhomphutha., lebokoseng la 1 letlapa.

Matšoao Hypothiazide ®

hypertension ea methapo (e sebelisoang ka bobeli ho monotherapy le hammoho le lithethefatsi tse ling tsa antihypertensive),

edema syndrome ea methapo e sa tšoaneng (ho nyekeloa ke pelo ho sa foleng, lefu la nephrotic, premenstrual syndrome, glomerulonephritis e hlobaetsang, ho se sebetse hantle ha reong, lefu la methapo ea methapo, kalafo ka corticosteroids),

taolo ea polyuria, haholoholo le lefu la tsoekere la nephrogen,

thibelo ea ho etsoa ha majoe ka har'a genitourinary trektrong ho bakuli ba qhekelletseng (phokotso ea hypercalciuria).

Bokhachane le pelehi

Hydrochlorothiazide e tšela sethala sa placental. Tšebeliso ea lithethefatsi ho "trimester" ea pele ea bokhachane e tiisitsoe. Ho trimesters ea II le ea boraro ea bokhachane, moriana o ka khethoa feela maemong a tlhokahalo e potlakileng, ha molemong oa 'm'a o feta kotsi e ka bang teng ho lesea le ho lesea. Ho na le kotsi ea ho ba le lefu la sethoathoa sa lesea kapa lesea le sa tsoa tsoaloa, thrombocytopenia le litlamorao tse ling.

Litlhare li fetela lebese la matsoele, ka hona, haeba ts'ebeliso ea moriana e hlile e hlokahala, ho anyesa ho lokela ho emisoe.

Hypothiazide

Hypothiazide ke lithethefatsi tsa maiketsetso tse tsoang ho sehlopha sa benzothiadiazine. Phello ea diuretic ea hypothiazide e bakiloe ke ho fokotseha ha mokhoa oa ho monya oa chlorine, ion ea sodium ho li-renal tubules. Ho eketseha ha sodium ho tsoa 'meleng ho kenyelletsa tahlehelo ea metsi. Ka lebaka la ho tlosoa ha metsi, palo ea mali a potoloha ea fokotseha, e lebisang ho fokotseha ha khatello ea mali (haeba e ne e phahame, khatello e tloaelehileng ea mali ha e fokotsehe). Setlhare se boetse se khothaletsa tlhahiso ea potasiamo, li-bicarbonates le ion ea magnesium ho tsoa 'meleng, empa ho isa tekanyong e tlase.

Matla a diuretic (diuretic) a qala lihora tse 1-2 kamora ho sebelisa moriana, o fihla hofihlella kamora lihora tse 4 mme o nka lihora tse 6-12. Tšebeliso ea nako e telele ea hypothiazide ha e fokotse phello ea eona ea diuretic. Ho fokotsa ts'ebeliso ea letsoai le lijo ho ntlafatsa litlamorao tsa moriana.

Khatello ea methapo ea kutlo le eona e fokotseha ka Hypothiazide. Setlhare se ka tšela ntho e ka mo sitisang. E pepesitsoe ka har'a moroto le lebese la matsoele. Ka ho se sebetse hantle ha moriana, ho lokolloa ha moriana ho fokotseha haholo.

Ntho e sebetsang ea lithethefatsi ke hydrochlorothiazide.

Pheko ea Hypothiazide

Ka botenya, ho na le tloaelo ea ho boloka metsi 'meleng ka lebaka la hydrophilicity ea tishu. Ntle le moo, hangata khahlano le semelo sa botona, ho hloleha ha pelo le pelo, ho eketsa mokoloto oa metsi. Hape ho na le tlhoko ea ho etsa kopo ea kalafo ea lithethefatsi tsa pelo feela, empa le diuretics. Ho diuretics, hypothiazide e sebelisoa hangata ho feta, ha e fuoa tšusumetso e ntle ebile e etsisa seoelo.

Leha ho le joalo, ts'ebeliso ea hypothiazide bakeng sa ho theola boima ba 'mele e lokela ho ba hlokolosi haholo mme e laetsoe ke ngaka feela. Ts'ebeliso ea diuretiki ena ntle le lebaka le letle e ka lebisa litlamorao tse mpe - mofuta o sa fetelletseng oa botona o tla fetoha litholoana hobane ts'ebeliso ea nako e telele ea li-diuretics e baka phello e makatsang: mokelikeli liseleng o bokellana le ho feta kapele.

Ho bonolo ebile ho molemo ho tlosa mokelikeli o eketsehileng 'meleng ho sebelisa li-decoctions le infusions tsa limela tsa kalafo (bere, li-Horsetail, jj.).
Haholoanyane ka ho theola boima ba 'mele