AMIX vet HTTs (AMIX vet STS)

Matšoao a sebeliso:

Mofuta oa lefu la tsoekere la Mofuta oa II, moo tsoekere ea mali e ke keng ea tšehetsoa ka botlalo ke ho theola boima ba 'mele, lijo le boikoetliso.

Tekanyetso ea moriana e khethoa ho latela liphetho tsa liteko tsa mali le tsa moroto bakeng sa tsoekere. Tekanyetso ea pele ea lithethefatsi ke 1 mg ea glimepiride 1 nako ka letsatsi. Ha tlhahlobo e nepahetseng ea boemo ba mokuli e fihlella, lethalinyana lena le sebelisoa e le kalafo e tšehetsang. Haeba taolo e khotsofatsang ea boemo ba mokuli e sa khonehe, tekanyetso e lokela ho eketsoa ka hloko (ho latela sephetho sa taolo ea glycemic) ho isa ho 2 mg, 3 mg kapa 4 mg ea glimepiride ka letsatsi beke e 'ngoe le e' ngoe ho isa ho tse peli.

Ho nka tekanyetso ea glimepiride e fetang 4 mg ka letsatsi ho fana ka ntlafatso maemong a khethehileng feela, 'me ho laetsoe ka kotloloho ka bonngoe. Tekanyo e phahameng e khothalletsoang ke 6 mg ea glimepiride ka letsatsi.

Ho bakuli bao tšebeliso ea litekanyetso tse phahameng tsa letsatsi le letsatsi tsa methapo e sa kang ea lebisa pusong e khotsofatsang ea metabolism ea carbohydrate, kalafo e ts'oanang le glimepiride e ka qala. Tekanyetso ea metformin e lokela ho tloheloa ka tekanyo e le 'ngoe,' me kalafo e nang le glimepiride e lokela ho qala ka litekanyetso tse tlase, tse lokelang ho eketsoa butle-butle ho isa tekanyetso e phahameng ea letsatsi le letsatsi, ho latela tekanyo e hlokahalang ea puseletso ea metabolic. Phekolo e joalo e kopaneng e lokela ho qaloa tlasa taolo ea ngaka.

Ho bakuli bao metabolism ea carbohydrate e sa lefelloeng esita le ka mor'a ho nka tekanyetso e phahameng ea letsatsi le letsatsi, haeba ho na le boemo ba tšohanyetso, o ka qala kalafo e ts'oanang le insulin. Bakuli ba joalo ba lokela ho tsoela pele ho nka tekanyetso e fetileng ea glimepiride 'me ka nako e ts'oanang ba qale ho sebelisa tekanyetso e nyane ea insulin, eo ka mor'a nako e itseng e eketsehang, ka tatellano, tekanyo ea tefo ea metabolic. Phekolo e joalo e kopaneng e lokela ho qaloa tlasa taolo ea ngaka.

Bongata

• Bohlokoa pakeng tsa ho ikoetlisa 'meleng le ho ja lijo tse nang le lik'habohaedreite haholo,
• Ho ferekana kapa (haholo-holo botsofaling) bokhoni bo sa lekaneng ba mokuli ba ho bona ngaka,
• Ho se sebetse ka liphio
• Ho nwa joala, haholoholo hammoho le ho tlola lijo,
• Ho se sebetse hantle ha sebete,
• Liphetoho tse ling tsa pathological tsamaisong ea endocrine e amang metabolism ea carbohydrate (mohlala, adenohypophysial kapa adrenocortical insuffence, dysfunction ea thyroid),
• Ts'ebeliso e tšoanang ea lithethefatsi tse ling (bona karolo "Ho sebelisana le lithethefatsi tse ling le mefuta e meng ea litšebelisano").

Haeba lintlha tse kaholimo le likarolo tsa hypoglycemia li le teng, o lokela ho tsebisa ngaka ea hau hanghang, kaha ho hlokahala hore ho be le tlhaiso-leseling ea bakuli ka hloko. Lintlha tse eketsang kotsi ea hypoglycemia li hloka phetoho ea li-Amiksu kapa mofuta kaofela oa kalafo. Litekanyetso li lokela ho fetoloa haeba mokhoa oa bophelo oa mokuli o fetoha kapa lefu le kopanetsoeng. Matšoao a hypoglycemia, a bonts'ang khanyetso ea adrenergic, a ka hlakoloa kapa a ba sieo ka botlalo maemong a ha hypoglycemia e hlaha hanyane ka hanyane ho bakuli ba nang le neuropathy ea autonomic, bakuli ba tsofetseng. Matšoao a ka boela a fokotsoa ho bakuli ba tšoaroang ka nako e tšoanang le b-adrenergic blockers ka reserpine, clonidine, guanethidine, kapa mekhoa e meng. Hypoglycemia, hoo e batlang e le maemong ohle, e ka emisoa ka potlako ke ho kenella ha lik'habohaedreite kapele, joalo ka tsoekere kapa tsoekere (mohlala, ka sebopeho sa karoloana ea tsoekere e halikiloeng ka lero la lero la litholoana kapa tee). Ka hona, mokuli o lokela ho lula a nkile bonyane ligrama tse 20 tsa tsoekere. Lisebelisoa tsa monko o monate oa maiketsetso ha li na thuso ea ho phekola hypoglycemia. Ho tsoa phihlelong ea ts'ebeliso ea lithethefatsi tse ling tsa sulfanylurea, hoa tsebahala hore, leha ho bile le katleho ea pele ea mehato ea kalafo e nkuoeng, ho khutla hoa hypoglycemia hoa khoneha. Ho lekola ka hloko boemo ba mokuli le hona hoa hlokahala. Hypoglycemia e matla e hloka kalafo ea hanghang tlasa taolo ea ngaka, 'me maemong a boima, ho kena sepetlele ho mokuli.

Litlamorao:

Matšoao a hypoglycemia: ho nyekeloa, ho tsekela, ho opeloa ke hlooho, ho hlatsa, ho tšoenyeha ka boroko, ho hloka thahasello, ho otsela, ho otsela, ho sitoa ho tsepamisa mohopolo, pono, ho ts'oaroa ha genesis e bohareng, ho fokotseha ho falimeha, matšoenyeho, pherekano, ho fokola hoa puo, ho ba mabifi le khatello ea maikutlo. Ntle le moo, ho ka etsahala hore ho be le liphetoho tse ka bang teng ka har'a maemo a holimo: tachycardia, khatello ea methapo ea kutlo, palpitations, mofufutso, matšoenyeho, pelo le arrhythmias ea pelo. Ho ferekana, ho thothomela, ho hlohlona, ​​ho sithabela ha maikutlo, ho hloka thuso, ho lahleheloa ke boitšoaro, ho otsela, ho otsela le ho se tsebe ho fihlela ho akheha, ho phefumoloha ho sa tebang le bradycardia ho ka etsahala.

Setšoantšo sa kliniki sa tlhaselo ea hypoglycemia se ka tšoana le setorouku. Kamora ho thatafatsa boemo ba glycemic, matšoao ana hangata a nyamela.

• Litho tsa kutlo ea kutlo: nakong ea kalafo (haholo-holo methati ea pele), ho fokola ka nakoana ha pono ho ka hlaha, ka lebaka la phetoho ea boemo ba tsoekere ea mali.
• Phekolo ea ka mpeng: tšitiso ea ka mpeng, joalo ka bohloko ba ka mpeng le lets'ollo, ho hlatsa, ho nyekeloa le pelo, ho utloa khatello kapa ho phahama ho epigastrium, maemong a sa tloaelehang ho na le keketseho ea tšebetso ea li-enzyme tsa sebete le ho hlohlona ha sebete (jaundice le cholestasis), hepatitis, e ka lebisang ho ho hloleha ha sebete.
• Sistimi ea potollo ea mali: Ho na le mathata a maholo a ka hlahang. Maemong a sa tloaelehang, thrombocytopenia mme, maemong a ikhethang, granulocytopenia, hemolytic anemia, leukopenia, erythrocytopenia, agranulocytosis le pancytopenia (ka lebaka la myelosuppression) lia khonahala.
• Litla-morao tse ling Liphetoho tsa mmele kapa tsa pseudo-allergic ka tsela ea urticaria, ho ruruha kapa ho hlohlona ka linako tse ling li ka hlaha. Haeba likhahla li hlaha, etela ngaka hang-hang.

Boitšoaro bo joalo, joalo ka molao, bo itekanetse, empa bo ka tsoela pele, bo tsamaisana le dyspnea le ho fokotseha ha khatello ea mali ho fihlela ho makala. Maemong a ikhethileng, ho ka ba le kutloisiso e eketsehileng ea letlalo ho nka ketso ea leseli, allergic vasculitis le ho theoha hoa boemo ba sodium e serum ea mali.

Ho sebelisana le meriana e meng le joala:

Tšebeliso ea lithethefatsi Amix le litokisetso tse ling tsa bongaka li ka lebisa keketseho e sa rateheng kapa ea fokolisa phello ea hypoglycemic ea ntho e sebetsang. Lithethefatsi tse ling li lokela ho nooa feela kamora ho buisana le ngaka (kapa joalo ka ha u laetsoe).

Sena se lokela ho nahanoa ha ho nka glimepiride ka li-inhibitors tsa CYP2C9 (kk. fluconazole) kapa li-inducers tsa CYP2C9 (mohlala, rifampicin).

Phihlelo ea kalafo e nang le glimepiride kapa tse ling tse tsoang ho sulfonylurea li bontša monyetla oa mefuta e joalo ea litšebelisano: tšusumetso ea phello ea ho theola litekanyetso tsa tsoekere ea mali. Maemong a mang, sena se lebisa ho hypoglycemia ha u ntse u nka e 'ngoe ea lithethefatsi tsena: phenylbutazone, azapropazone le oxyphenbutazone, insulin le molomo antidiabetic acid, metformin, salicylates ea tara-amino salicylic acid, li-anabolic steroid le lihormone tsa banna tsa thobalano, chloramphenicolinum, antifumorofenololinin li-fibrate, li-inhibitors tsa ACE, fluoxetine, allopurinol, sympatholytics, cyclo-, tri-taifosfamidiv, sulfinpyrazone.

Ho fokotseha hoa katleho ea lithethefatsi (ho fokotseha ha phello ea ho fokotsa litekanyetso tsa tsoekere ea mali) kapa ho eketseha ha sephetho sa tsoekere ea mali ho tsoa taolong e tšoanang ea Amix ka lithethefatsi tse latelang: lithethefatsi tsa estrogen le tsa proureogen, tsa saluretics le thiazide, lithethefatsi tse susumetsang, "glucocorticoids", "phenothiazine" , nicotinic acid (ka litekanyetso tse kholo) le li-acid tse tsoang nicotinic, li-laxatives (tšebeliso ea nako e telele), phenytoin, diazoxide, tsoekere, barbiturates, rifampicin, aceto amide.

Ts'ebeliso e tšoanang ea bahanyetsi ba H2-receptors, b-blockers, clonidine le reserpine e ka lebisa ho ts'oenyeho kapa ea fokolisa ho fokotseha ha tsoekere ea mali e bakiloeng ke ho nka Amiksu. Li-sympatolytics tse kang b-blockers, clonidine, gaunetidine le reserpine li ka pata kapa tsa tlosa matšoao a lefu la adrenergic, la lebisa ho hypoglycemia. Tšebeliso e mpe ea joala e ka eketsa kapa ea fokolisa phello ea hypoglycemic ea glimepiride ka tsela e sa lebelloang. Glimepiride e ka ntlafatsa kapa ea fokolisa phello ea lihlahisoa tsa coumarin.

Sebopeho le thepa:

Moetso: Letlapa le le leng le na le glimepiride 1.2, 3 kapa 4 mg.

Foromo ea tokollo: Matlapa a 1 mg No. 10x3, No. 10x9, No. 10x12.

Glimepiride ke ntho e sebetsang ea lithethefatsi, e hlahisoang ke sulfonylurea. E sebelisoa ka molomo, e na le ts'ebetso ea hypoglycemic. E hlohlelletsa tlhahiso ea insulin ka lisele tsa beta tsa manyeme, e phahamisa maikutlo a methapo ea kutlo ho insulin, e eketsa ho lokolloa ha insulin .. Kamora taolo ea molomo, ho kenngoa ha glimepiride ke 100%. Ho ja ha ho ame bioavailability, empa ho kokobetsa hanyane feela tekanyo ea ho amoheloa. Cmax (boholo ba mahloriso a serum ea mali) e fihlella lihora tse 2,5 ka mor'a ho tsamaisoa ka molomo (karolelano serum ea mali ke 0.3 μg / ml ha u nka tekanyetso e ngata ea 4 mg ka letsatsi). Ho na le kamano ea mola pakeng tsa lethalinyana le Cmax, le lipakeng tsa lethalinyana le AUC (sebaka se tlas'a khefu ea nako ea mahloriso).

Tsamaiso ea glimepiride e tšoailoe ke palo e tlase haholo ea phepelo (hoo e ka bang lilithara tse 8,8), e batlang e lekana le bophahamo ba kabo ea albin, clearance e tlase (hoo e ka bang 48 ml / min.), Tekanyo e phahameng ea ho tlama liprotheine tsa plasma (> 99%). Biotransformation le ho felisoa: halofo ea plasma ea halofo ea bophelo ba glimepiride ke lihora tse 5 ho isa ho tse 8. Bohlokoa bona bo bohlokoa bakeng sa ho khetholla ho tsepamisa mohopolo oa serum glimepiride kamora litekanyetso tse ngata. Kamora ho nka tekanyetso e kholo, keketseho e nyane nakong ea halofo ea plasma bakeng sa glimepiride e hlokometsoe.

Maemo a polokelo: boloka ka lithempereichara ho fihlela ho 30 ° C. Tloha hole le bana.

Fomu ea tokollo

• Amix 1: matlapa a oval a pinki a nang le mola o arolang mahlakore ka bobeli.
• Amix 2: matlapa a tlotsitsoeng ka botala bo nang le mola o arolang mahlakore ka bobeli.
• Amix 3: matlapa a o-yellowish a nang le mola o arolang mahlakore ka bobeli.
• Amix 4: matlapa a maputsoa a 'mala o moputsoa a nang le mola o arolang mahlakore ka bobeli.

Matlapa a 10 ka blister - lilomo tse tharo, tse robong kapa tse leshome le metso e 'meli ka lebokoseng la lebokose.

Pharmacodynamics le pharmacokinetics

Pharadodynamics

Glimepiride Na ho joalo hypoglycemic agent bakeng sa tsamaiso ea molomo (derivative sulfonylureas) E kenya tshebetsong khetho insulin lisele tsa pancreatic B, li ntlafatsa tokollo insulineketsa kutloisiso ea lisele ho limolek'hule insulin.

Mofumahali

Kamora ho nka bioavailability glimepiridee atamela 100%. Lijo ha li ame ho amoheloa ha motho ka bongata, empa li bo thibela hanyane. Ho tsepamisa mohopolo ho madi (E behantsoe le lihora tse 2-3 kamora ho kenella.)

Tekanyo ea ho tlama liprotheine tsa plasma e feta 99%. Bophelo ba halofo ke lihora tse 6-8. E etselitsoe ruri. E pepesitsoe ka har'a moroto le ka mala.

Contraindication

Lefu la tsoekeremofuta oa pele lefu la tsoekere, lefu la tsoekere la ketoacidosis, boimana kapa lebone. Hape, sethethefatsi se ke ke sa khothalletsoa bakuli ba tlhokomeliso ho likarolo tsa moriana, litlamorao sulfonylureas kapa ho ba bang lithethefatsi tsa sulfa.

Litlamorao

Kholiso e ka bang teng ea matšoao a latelang hypoglycemia: "Wolf" takatso ea lijoho nyekeloa ho hloka thahaselloho hlatsa ho otsela, hlooho e bohloko, ho tšoenyeha, ho ba mabifi,ho tšoenyeha ka boroko, ho sithabela maikutlo, ho fokotseha ho arabela, pherekano, khatello ea maikutloho senyeha ha puo, ho senyeha ha pono, hoaba, ho thothomelatlolo ea maikutlo paresisho tsekela delirium, literateng tse boharengho lahleheloa ke kelello bradycardia. Hape hoa khoneha adrenergicBoitšoaro: maikutlo a ho tšoenyeha, mofufutso, khatello ea kelello ea methapoho tsitsa angina pectoris, tachycardia, arrhythmia.

Ka ea pono: ho sitisoa ha nakoana hoa pono.

Ka tshilo ya mmele: bohloko ba ka mpeng, ho nyekeloa ke pelo, ho hlatsa, ho utloa bohloko ka botlalo ho epigastrium, lets'olloPhetoho ea litaba tsa enzymes tsa sebete, hepatitis.

Ka hematopoiesis: leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, granulocytopenia, erythrocytopenia, pancytopenia.

Lintho tse ling tse re utloisang hampe: ho hlohlona, urticaria, dyspneakhatello ea khatello.

Maemong a sa tloaelehang haholo, ho ka bonoa tse latelang: photosensitization, allergic vasculitisfokotsa maemo sodium mading.

Litaelo tsa ho sebelisoa (Mokhoa le litekanyetso)

Maemo a mantlha a kalafo e atlehileng: lijo, ho ikoetlisa kamehla le ho lekola mali le urine ka mehla. Tekanyetso ea moriana e khethoa ke litholoana tsa tlhahlobo.

Tekanyetso ea pele ea lithethefatsi ke 1 mg glimepiride letsatsi le letsatsi. Tekanyetso e tšoanang e sebelisoa e le kalafo e tšehetsang ha u fumana taolo holim'a boemo ba mokuli.

Haeba taolo e lakatsehang holima boemo ba mokuli e sa khonehe, litekanyetso li eketseha ka 1, 3 kapa 2 mg glimepirideka letsatsi e mong le e mong ho isa libekeng tse peli.

Kamoheloglimepiride ho feta 4 mg ka letsatsi ho ntlafatsa maemong a khethehileng feela. Tekanyetso e phahameng e fihla ho 6 mg ea moriana ka letsatsi.

Ho bakuli ntle le puseletso bakeng sa mathata a amanang le metabolism ea carbohydrate, esita le ka mor'a ho qeta tekanyetso e phahameng, kalafo e ka qala insulin ha feela ho hlokahala. Bakuli ba joalo ba lokela ho tsoela pele ho sebelisa tekanyetso e fetileng ea lithethefatsi 'me ka nako e ts'oanang ba qale ho sebelisa tekanyetso e nyane ea insulin, nakong e tlang ba lumelloa hore butle-butle ba eketsehe ho latela boemo ba puseletso ea metabolic.

Ho ajoa ka tekanyetso ea letsatsi le letsatsi

Ka tloaelo ho lekane hore 'mele o noe tekanyetso e le' ngoe ea letsatsi le letsatsi pele ho lijo tsa hoseng. Haeba mokuli a lebala ho nka tekanyetso e latelang, joale tekanyetso e latelang ha e hloke ho eketsoa.

Phetoho ea tekanyetso e latelang

Nakong ea kalafo, keketseho ea maikutlo a insulin le tlhoko e fokotsehileng ea glimepiride. Ka hona, ho thibela hypoglycemia litekanyetso li lokela ho fokotsoa ka nepo kapa ho lahleloe lithethefatsi. Ka ho eketseha kapa ho fokotseha ha boima ba 'mele, mekhoa ea bophelo e fetoha kapa ponahalo ea lintho tse ling tse eketsang kotsi ea hypoglycemia kapa hyperglycemia, ho hlokahala ho hlahloba litekanyetso tsa litekanyetso tsa moriana.

Phetoho e tsoang ho li-agents tse ling tsa hypoglycemic tse sebelisang Amix

Maemong ana, tekanyo ea phello ea lithethefatsi 'meleng le halofo ea bophelo e lokela ho tsotelloa. Ts'ebeliso ea nako e telele mahlahana a li-antidiabetes ka bophelo bo bolelele ba halofo, ho khothalletsoa ho qala kalafo ea Amix kamora ho felisoa ha nako ea ho felisoa, hobane phello ea tlatsetso e ka etsahala.

Ho fetoha ho tloha ho insulin ho lokisa

Maemong a khethehileng, ha boemo ba bakuli ba nang le lefu la tsoekere la 2 bo laoloa insulin, matšoao a ka bonahala a fetohela ho glimepiride. Phetoho ea Amix ho bakuli bana e lokela ho etsoa ka taolo ea ngaka.

Bongata

Kamora ho sebelisa moriana o feteletseng oa lithethefatsi, ponahalo ea hypoglycemia, e ka tšoarellang ho tloha lihora tse 12 ho isa ho matsatsi a 3. Ho kgothaletswa ho pepesetsoa sepetleleng ka kakaretso.Matšoao a a feteletseng a ka kenyelletsa ho hlatsa kapa ho nyekeloa ke pelo, bohloko ba ka mpeng, ho ruruha, pono e fifalitsoeng, thothomela mathata a ho hokahanya, ho otsela, ho hloka boroko, komisile cramps.

Phekolo ea bongaka bo fetisisang e na le ho etsa sehlaha sa mpa, metsi a nooang, khabone e sebetsang le sodium sulfate. Hape, o lokela ho qala ho sebelisa glucose kapele kamoo ho ka khonehang. Pheko e eketsehileng e lokela ho ba matšoao.

Tšebelisano

Ha e kopantsoe le Phenylbutazone, Azapropazone, Metformin, Oxyphenbutazone, insulin, li-antidiabetic tsa molomo, salicylates, li-anabolic steroids, li-androgens, li-anticoagulants tsa coumarin, chloramphenicol, Fenfluramine, fibratins, Acidumoliponofilininininininininininininininhypoglycemia ea khonahala.

Ha u ntse u sebelisa estrogens, saluretics, progestogens, thiazide diuretics, glucocorticoids, lithethefatsi tse tsosang takatso ea qoqotho, li-derivatives tsa phenothiazine (Adrenaline, Chlorpromazine), sympathomimetics, nicotinic acid le lihlahisoa tsa eona, Phenytoin, Glucagon, Diazoxide, Rifampicin, Barbiturates, Acetosolamideho fokolisa matla a phello ea moriana le keketseho ea khatello ea tsoekere maling.

Glimepirideliphetoho lithethefatsi tse kang coumarin.

Litaelo tse khethehileng

Qalong ea kalafo, mokuli a ka eketsa kotsi ea hypoglycemia- sena se hloka ho hlokomela boemo ba hae ka hloko. Lintho tse kenyang khatello ea tsoekere e ngata ea plasma li kenyelletsa: khaello ea phepo e fosahetseng, liphoso tsa phepo e nepahetseng, khaello ea phepo e nepahetseng, lijo tse se nang phepo e ntle le ho tlola lijo.

Amipyrid, Amaril, Glayri, Glemaz, Glianov, Glimaks, Glinova, Glyrid, Dimaril, Diapirid, Altar, Perinel, Elgim.

Ha ho na boiphihlelo ka ts'ebeliso ea lithethefatsi ho bana.

Nakong ea bokhachane le pelehi

Basali baimana ba kileng ba sebelisa moriana ba isoa kalafong insulin

Haeba mokuli a hloka ho nka insulin, o eletsoa hore a hane ho lactation.

Phihlelo ea ho sebelisa lithethefatsi ha e ea lekana ho ba le setšoantšo sa sepheo sa eona. Hona joale, lipapiso tsa molomo tsa moriana ona li sebelisoa hangata. Lichelete tse thehiloeng ho eona glimepiride ke litlhare tsa khetho tsa lefu la tsoekere mofuta oa bobeli le ho thusa ho khetholla ts'ebeliso ea liente tsa insulin. Ha e sebelisoa ho tekanyetso e khothalletsoang, litlamorao ha li na seoelo.

AMIX vet HTTs (AMIX vet STS)

Lebitso la khoebo la sehlahisoa sa litlhare: AMIX ™ Vet CTZ 150 mg / g (AMIX ™ Vet STS 150 mg / g).

Lebitso le sa ameheng la machabeng: chlortetracycline.
Foromo ea litekanyetso: phofo bakeng sa tsamaiso ea molomo.
AMIX ™ Vet XTC 150 mg / g e na le 1 g e le motsoako o sebetsang: chlortetracycline - 150 mg (joalo ka chlortetracycline hydrochloride), e le lintho tse thusang: lihlahisoa tsa belisoa tsa Streptomyces aureofaciens le phofo ea koro ho fihlela ho 1 g.
Ka ponahalo, AMIX ™ Vet XTC 150 mg / g ke phofo ho tloha ho sootho se bobebe ho isa ho sootho se lefifi.
AMIX ™ Vet XTC 150 mg / g e fumaneha ka mekotleng ea foil e mekato e meraro e nang le mokato o ka hare oa polyethylene kapa mekotla ea pampiri e nang le mekato e mengata.
AMIX ™ Vet XTC 150 mg / g e bolokiloe moqomong o tiisitsoeng oa moetsi, ka thoko le lijo le fepa, sebakeng se omileng se lefifi ka mocheso oa 2 ° C ho isa ho 25 ° C.
AMIX ™ Vet XTC 150 mg / g e lokela ho bolokoa e sa fihlelloe ke bana.
Sethethefatsi se sa sebelisoang se lahloa ho latela litlhoko tsa molao.

Sebopeho sa pharmacological:

AMIX ™ Vet CTZ 150 mg / g ke setlhare sa antibacterial sa sehlopha sa tetracycline.
Chlortertracycline, e leng karolo ea lithethefatsi e na le bongata ba liketso tsa antibacterial, e sebetsa khahlano le likokoana-hloko tse mpe tsa gram, tse kenyelletsang Escherichia coli, Klebsiella pneumoniae, Proteus spp. Salmonella spp., Staphylococcus spp. Pasteurella multocida, Streptococci ntle le, Rickettsia spp., Chlamydia, Protozoa le Mycoplasma spp.
Mochine oa "bacteriostatic" oa "antibiotic" o hatella karolo ea protheine ea kokoana-hlokoa ka seleng ea microbial e maemong a ribosomal, e thibelang karohano le ho theoa ha lebota la sele.
Chlortetracycline ha e kenelle ka ho felletseng ka seterateng sa gastrointestinal. Tekanyo ea ho monya e fokotseha ha ho e-na le matsoai a qhibilihang a ions tse peli le tse tharo tse nang le li-tetracyclines tse etsang mechini e tsitsitseng. Chlortetracycline e kopana hantle le liprotheine tsa plasma mme e hasoa hohle ho pholletsa le 'mele, e fihla sehlohlolong se phahameng ka ho fetisisa sebeteng, mokokotlong, matšoafong le libakeng tse sebetsang tsa kaho ea masapo. Palo e phahameng ea tetracycline maling e fihlella lihora tse 4 kamora ho tsamaisoa. Metsoako ea phekolo e phehella lihora tse 12-18. Tetracycline ha e kenelle mokelikeli oa lesapo la mokokotlo, empa boemo ba eona bo ka eketseha ka ho kenella ha meninges. Bophelo ba halofo ea chlortetracycline ke lihora tse 8,8. E hlahisoa haholo ka moroto le makhopho. Ka makhopho, ho fihlela 10% ea kakaretso ea tetracycline e kentsoeng e ka ts'oaroa.

Thulaganyo ya Tiriso:

AMIX ™ Vet XTC 150 mg / g e ngoletsoe likolobe, likonyana, manamane molemong oa kalafo, likhoho bakeng sa merero ea bongaka le ea kalafo ho mafu a hlobaetsang le a sa foleng a sistimi ea phefumoloho, tsamaiso ea genitourinary, gastrointestinal le tšoaetso e ngoe ea mantlha le ea bobeli ea baktheria. ethnologies eo li-agents tsa eona tsa causative li amehang ho chlortetracycline.
AMIX ™ Vet XTC 150 mg / g e thibetsoe ho li-ruminants tsa batho ba baholo tse nang le tšilo ea mmele e tsoetseng pele ea cicatricial, ho bea hens, hammoho le liphoofolo tse nang le bothata ba ho renal le hepatic tse sa lekaneng.
Etsa kopo ka lijo ka mokhoa oa sehlopha kapa ka bonngoe ka letsatsi bakeng sa matsatsi a 5-10.

Phekolo ea sehlopha:
Ho kenyelletsa 3.0 - 4.0 kg ea moriana ka toni ea motsoako (e lumellanang le 450-600 g ea chlortetracycline ka boima ba thane kapa 20-30 mg / kg ea boima ba 'mele).
Tekanyetso ea letsatsi le letsatsi ea lithethefatsi e bontšoa tafoleng:

Thibelo:
Kenya litekanyetso tse 1,5-2,0 tsa moriana ka tekanyo e le 'ngoe ea motsoako oa phepelo (e lekanang le 225-300 g ea chlortetracycline / ton ea fepa kapa 10-15 mg / kg ea boima ba' mele).

Bongata

Matšoao a bosholu ba joala ha a so tsejoe.

Mefuta:

Litlhaloso tsa ketso ea moriana nakong ea ts'ebeliso ea hae ea pele le ho hula ha li so theoe.
Ho tlola tekanyetso e latelang ea moriana ho lokela ho qojoa, kaha sena se ka lebisa ho fokotseha ha katleho ea kalafo. Haeba nako e boletsoeng bakeng sa tšebeliso ea lithethefatsi e sa phetoe, e lokela ho sebelisoa kapele kamoo ho ka khonehang, ka tekanyetso e le 'ngoe ho latela morero o le mong.
Litlamorao, ntle le linyeoe tsa hypersensitivity ea motho ka mong likarolo tsa moriana, ha li so fumanoe. Ka ho eketseha hoa kutloisiso ea motho ka mong ea phoofolo ho chlortetracycline le ponahalo ea
ea karohano e bakoang ke ho se sebetsehe, tšebeliso ea AMIKSTM ve XTC 150 mg / g e emisitsoe mme kalafo ea takatso e entsoe.
Se ke oa sebelisa AMIX ™ Vet XTC 150 mg / g hammoho le lithibela-mafu tsa bactericidal (penicillin, cephalosporins, jj), calcium chloride, calcium gluconate, ammonium chloride, antacids, kaolin, litokisetso tse nang le tšepe, magnesium, calcium le aluminium. phokotseho e ka bang teng mesebetsing ea eona ea antibacterial.
Ho bolaoa ha manamane le likonyana bakeng sa nama ha hoa lumelloa pele ho matsatsi a 12, likolobe le likhoho - matsatsi a 10 kamora ts'ebeliso ea ho qetela ea lithethefatsi. Nama ea liphoofolo e qobelloang ho bolaoa pele nako e fela e ka sebelisoa ho fepa liphoofolo.

Thibelo ea Botho

Ha o etsa mekhoa ea kalafo le ea thibelo ea tšebeliso ea lithethefatsi AMIX ™ Vet XTC 150 mg / g, melao e akaretsang ea bohloeki le boits'ireletso tse fanoang ha o sebetsa le lithethefatsi e lokela ho bolokoa.
Qetellong ea mosebetsi, hlatsoa matsoho a hau ka metsi a futhumetseng le sesepa.
Ts'ebetso eohle e sebetsang le AMIX ™ Vet XTC 150 mg / g e khothalletsoa ho sebelisa lisebelisoa tsa ts'ireletso tsa motho (bathate, headgear, liatlana tsa rabara, likhalase tsa polokeho, phefumoloho kapa maske ea sefahleho). Ha o ntse o sebetsa le moriana ona, ho thibetsoe ho noa, ho tsuba le ho ja lijo. Qetellong ea mosebetsi, o lokela ho hlatsoa sefahleho le matsoho ka sesepa le metsi hantle, a hlatsoe molomo.
Haeba u ka kopana ka tšohanyetso le lithethefatsi ka letlalo kapa li-membrane tsa mucous, e hlapolle ka metsi a mangata, haeba e ka ba ka mahlong a hau, itlhatsoe hang hang ka metsi ebe u sheba ngaka ha ho hlokahala.

Bophelo ba lehlohlo le polokelo:

Bophelo ba setebele sa lithethefatsi tlasa maemo a polokelo ka har'a sephutheloana se tiisitsoeng ke lilemo tse peli ho tloha ka letsatsi la tlhahiso, kamora ho bula sephutheloana - ha ho feta matsatsi a 28, ho fepa - ha ho feta matsatsi a 3.

Se ke ua sebelisa lithethefatsi kamora letsatsi la ho felloa ke nako.
AMIX ™ Vet XTC 150 mg / g e bolokiloe moqomong o tiisitsoeng oa moetsi, ka thoko le lijo le fepa, sebakeng se omileng se lefifi ka mocheso oa 2 ° C ho isa ho 25 ° C.
AMIX ™ Vet XTC 150 mg / g e lokela ho bolokoa e sa fihlelloe ke bana.
Sethethefatsi se sa sebelisoang se lahloa ho latela litlhoko tsa molao.

Lenane lohle le litaelo tsa lihlahisoa tsa bongaka li ka fumaneha lethathamong la lihlahisoa sebakeng sa rona sa marang-rang. Mabapi le theko, hammoho le monyetla oa ho reka u tla thabela ho tsebisa batsamaisi ba rona.

Amix sebopeho

• Letlapa le leng la lithethefatsi Amix 1 e na le 1 mg glimepiride.
• Letlapa le leng la lithethefatsi Amix 2 e na le 2 mg glimepiride.
• Letlapa le leng la lithethefatsi Amix 3 e na le 3 mg glimepiride.
• Letlapa le leng la lithethefatsi Amix 4 e na le 4 mgglimepiride.

Lisebelisoa tse ling: povidone 25, lactose, polysorbate 80, cellulose ea microcrystalline, crospovidone, silicon dioxide, magnesium stearate, iron oxide, dae.

Amix - Litaelo tsa ho sebelisoa

Maemo a mantlha a kalafo e atlehileng: lijo, ho ikoetlisa kamehla le ho lekola mali le urine ka mehla. Tekanyetso ea moriana e khethoa ke litholoana tsa tlhahlobo.

Tekanyetso ea pele ea lithethefatsi ke 1 mg ea glimepiride letsatsi le letsatsi. Tekanyetso e tšoanang e sebelisoa e le kalafo e tšehetsang ha u fumana taolo holim'a boemo ba mokuli.

Haeba taolo e lakatsehang holima boemo ba mokuli e sa khonehe, litekanyetso li eketseha ka 1, 3 kapa 2 mg ea glimepiride ka letsatsi letsatsi le leng le le leng ho isa libeke tse peli.

Ho nka glimepiride e fetang 4 mg ka letsatsi ho fana ka ntlafatso maemong a ikhethang feela. Tekanyetso e phahameng e fihla ho 6 mg ea moriana ka letsatsi.

Ho bakuli ntle le puseletso bakeng sa metabolism ea carbohydrate e senyehileng, le kamora ho sebelisa tekanyetso e kholo, kalafo ea "insulin" e ka qala feela ha ho hlokahala ka botlalo. Bakuli ba joalo ba lokela ho tsoela pele ho sebelisa tekanyetso e fetileng ea lithethefatsi 'me ka nako e ts'oanang ba qale ho sebelisa tekanyetso e nyane ea insulin, nakong e tlang ba lumelloa hore butle-butle ba eketsehe ho latela boemo ba puseletso ea metabolic.

Ho ajoa ka tekanyetso ea letsatsi le letsatsi

Ka tloaelo ho lekane hore 'mele o noe tekanyetso e le' ngoe ea letsatsi le letsatsi pele ho lijo tsa hoseng. Haeba mokuli a lebala ho nka tekanyetso e latelang, joale tekanyetso e latelang ha e hloke ho eketsoa.

Phetoho ea tekanyetso e latelang

Nakong ea kalafo, ho eketseha ha maikutlo a insulin le ho fokotseha ha tlhoko ea glimepiride hoa khoneha. Ka hona, ho thibela hypoglycemia, litekanyetso li lokela ho fokotsoa ka nepo kapa sethethefatsi se lokela ho felisoa. Ka ho eketseha kapa ho fokotseha ha boima ba 'mele, liphetoho tsa mekhoa ea bophelo, kapa lintlha tse ling tse eketsang kotsi ea hypoglycemia kapa hyperglycemia, ho hlokahala hore o hlahlobe hape litekanyetso tsa litekanyetso tsa moriana.

Phetoho e tsoang ho li-agents tse ling tsa hypoglycemic tse sebelisang Amix

Maemong ana, tekanyo ea phello ea lithethefatsi 'meleng le halofo ea bophelo e lokela ho tsotelloa. Ka tšebeliso ea nakong e fetileng ea li-antidiabetesic agents tse nang le nako e telele ea bophelo, ho kgothaletsoa ho qala kalafo ea Amix kamora ho fela ha nako ea ho felisoa, hobane phello ea tlatsetso e ka etsahala.

Ho fetoha ho tloha ho insulin ho lokisa

Maemong a khethehileng, ha boemo ba bakuli ba nang le lefu la tsoekere la 2 bo laoloa ke insulin, matšoao a ho fetoha ha glimepiride a ka hlaha. Phetoho ea Amix ho bakuli bana e lokela ho etsoa ka taolo ea ngaka.