TromboMag® (TromboMag)

Moriana o thibela ts'ebetso ea cycloo oxygenase 1 le 2 ka mokhoa o ikhethileng, o nkang karolo e sebetsang taolong ea motsoako oa prostaglandin (o baka ho ruruha le ho theha lefu la bohloko).

Matlapa a Thrombopol a na le litla-morao tsa antiges, anti-inflammatory, antipyretic.

Karolo e sebetsang ke acetylsalicylic acid.

Phokotseho ea li-prostaglandins ho setsi sa thermoregulation e baka ho theoha ha mocheso oa 'mele ka lebaka la mofufutso o eketsehileng le vasodilation ea palo ea letlalo. Ka lebaka la litlamorao tsa karolo ea mantlha le tsa pherekano, phello ea li-analgesic ea atleha.

Setlhare se fokotsa mosebetsi thrombosis ka lebaka la khatello ea motsoako oa thromboxane A2 liseleng tsa mali ka liplatelete. Lithethefatsi li liehisa ho khabisoa le ho kopana ha liplatelete.

E fihlelletsoe ka thuso ea lithethefatsi Thrombopol (tekanyetso e le 'ngoe) antiplatelet athari bolokiloe matsatsi a 7. Ho bakuli ba nang le angina e sa tsitsang, lithethefatsi li fokotsa kotsi ea ho tšoaroa ke myocardial, lefu la lefu.

Moriana o sebelisetsoa thibelo ea mantlha le ea bobeli.

Tekano ea letsatsi le letsatsi ea ligrama tse 6 e eketsa nako ea prothrombin, e thibela ho kopana ha prothrombin ka har'a lithane tsa sebete.

Tlas'a ketso ea acetylsalicylic acid, mohopolo oa lintho tse kopaneng oa fokotseha (2,7,9,10), ts'ebetso ea plasma ea fibrinolytic ea eketseha.

Nakong ea ts'ebetso ea ho buoa, setlhare se eketsa khafetsa mathata a hemorrhagic, se eketsa monyetla oa ho tsoa mali.

Moriana oa Thrombopol o matlafatsa ts'ebetso ea ho chesa uric acid (Ts'ebetso ea uric acid reabsorption maling a liphio e tšoenyehile).

Matšoao a ho sebelisoa

Moriana o fuoe phomolo lefu la bohloko (bonolo, e itekanetseng) ea tlhaho e fapaneng: leino le opang, migraine, hlooho, neuralgia, algodismenorea, radicular syndrome, lumbago, myalgia, arthralgia, hlooho e nang le ho tlohela joala syndrome.

Seokobatsi se sebelisetsoa febrile syndrome khahlano le semelo sa tšoaetso ea mafu a tšoaetsanoang le a tšoaetsanoang.

Contraindication

Litaelo tsa tšebeliso ea thrombopol ha li khothaletse ho fana ka moriana oa mamello ho acetylsalicylic acid, o nang le hemorrhagic diathesisho tsoa mali ka mpeng, le liphetoho tse senyehang le tse ruruhang tsamaisong ea tšilo ea lijo sethaleng se matla, le asthma ea bronchial (e leng mofuta o khothalletsoang ke tšebeliso ea li-salicylates le meriana ea NSAID), ka kalafo e tšoanang methotrexate litekanyetso tsa 15 ka beke kapa ho feta.

Matlapa a Thrombopol ha a fuoe ho emara, ha a ntse a anyesa. Moriana o kopantsoe le bana.

Litlamorao

Thrombopol e ka baka ho nyekeloa, Reye syndrome (E amanang le sebete ho hloleha, ka kopanelo le ka potlako a tsoela pele ho a hlobaetsang mafura a sebete le concomitant encephalopathy), likarabo tsa allergic (ka mokhoa oa bronchospasm, angioedema le lekhopho la letlalo), lets'ollo, phokolo ea mali, thrombocytopenia, gastralgia, takatso e fokotsehileng, leukopenia.

Pheko ea nako e telele e ka baka hlooho ea hlooho, ho tsekela, ho tsoa mali, hypocoagulation, ho ruruha le ho ruruha ha lisele tsa tsamaiso ea methapo ea lijo, ho hlatsa, bronchospasm, tinnitus le ho fokotseha hoa matla a pono. bohareng ba jadeHo ferekana kelellong, ho ruruha, matšoao a ho hloleha ha pelo, meningitis ea asepticnephrotic syndrome, ho hlobaela ho matla ha renal, necrosis ea papillary, azotemia ea prerenal hammoho le hypercalcemia le hypercreatininemia, ho eketsa li-enzyme tsa sebete.

Thrombopol, litaelo tsa tšebeliso (Mokhoa le litekanyetso)

Thrombopol e nkuoa ka molomo. Litlamorao tse khahlanong le ho ruruha le tsa analgesic li hlahisoa ke litekanyetso tsa moriana o fetang 400-500 mg.

Ka bohloko le lefu la mokokotlo, khetha ligrama tse 0,5-1 ka letsatsi (tekanyetso tse 3).

Nako ea phekolo ha ea lokela ho feta libeke tse peli. Pilisi e le 'ngoe bakeng sa mefuta ea litlhare tse sebetsang hantle ke ligrama tse 0,25-1 (litekanyetso tse tharo ka letsatsi).

Bongata

Matšoao a mangata haholo: ho hlatsa, ho nyekeloa ke pelo, ho hema ka potlako, tinnitus, bothata ba ho utloa le ba pono, hlooho e bohloko, ho otsela. Ka tekanyo ea motsoako o sebetsang o fetang 500 mg ka kilo, ho ka ba le sephetho se bolaeang.

Hlatsoa mpa, hlatsa, u hlatsoe mashala a mangata. U ke ke ua nka barbiturates. Ha ho na litlhare.

Tšebelisano

Thrombopol e khona ho ntlafatsa litlamorao methotrexatefokotsatumello ea ho pheta.

Moriana o ntlafatsa phello ea heparin, narcotic analgesics, anticoagulants e sa tobanghypoglycemic agents, antiplatelet agents thrombolyticssulfonamides.

Acetylsalicylic acid e fokotsa katleho ea lithethefatsi tsa phepo (furosemide, spironalokton), lithethefatsi tse thibelang antihypertensive, meriana ea uricosuric(sulfinpyrazone, benzbromarone).

Litokisetso tse nang le Ethanol, ethanol ka boeona le glucocorticosteroids eketsa phello e senya ea lithethefatsi leboteng la mucous la tšilo ea lijo, tse ka bakang mali ho tsoa ka mpeng.

Thrombopol e eketsa boemo ba barbiturates, digoxin le lithium letsoai maling.

Ho fufuleloa hoa fokotseha ka kalafo e tšoanang antacid.

Lithethefatsi tsa Myelotoxic li matlafatsa phello ea hematotoxic ea thrombopol.

Litaelo tse khethehileng

Nako ea ho nka acetylsalicylic acid e le ho fihlela phello ea analgesic ntle le ho buisana le ngaka ha ea lokela ho feta matsatsi a 5.

Thrombopol ha e fuoe bakeng satšoaetso ea allergic myocarditisramatiki, rheumatism, pericarditis le rheumatic chorea.

Setlhare se hlakotsoe matsatsi a 5-7 pele ho ts'ebetso e ka etsahalang.

Phekolo ea nako e telele e hloka tlhahlobo ea mali ea boloi ea tlhaho le ho hlahloba lipalo tsa mali.

Ho bana, ho nka Thrombopol ho ka baka lefu la Reye (ho eketseha ha boholo ba sebete, nts'etsopele ea nako e mpe ea encephalopathy, ho hlatsa nako e telele, ho sa nahaneleng).

Ho phekola ka nako e tšoanang meriana e sitisang acidity ea lero la gastric, ho ka fokotsa haholo phello e halefisang ea acetylsalicylic acid leboteng la mucous la tsamaiso ea tšilo ea lijo.

Thrombopol ke tšobotsi litlamorao tsa teratogenic (koalo pele ho nako ea ductus arteriosus, cleavage ea kamore e kaholimo le liphetoho tse ling ho ntlafatso ea fetal).

Ho bakuli ba nang le lefu la gout, moriana o ka baka tlhaselo e matla ka lebaka la ho fokotseha ha uric acid e tlohang ha o ntse o nka acetylsalicylic acid.

Ho hana ka botlalo ho noa lino tse nang le joala nakong eohle ea kalafo ho hlokahala.

Mokhoa oa ho sebelisa: litekanyetso le kalafo

Ka hare, lihora tse 1-2 kamora ho ja, nako e le 'ngoe ka letsatsi.

Letlapa la tlhophiso ea TromboMag le metsoa kaofela (le ka hlafuna kapa la silakanngoa), la hlatsuoa ka metsi.

Setlhare sena se reretsoe tšebeliso ea nako e telele. Nako ea kalafo e khethoa ke ngaka.

Thibelo ea mantlha ea mafu a pelo le methapo ea pelo, ha ho na le lintho tse ka bang kotsi (mohlala, lefu la tsoekere, hyperlipidemia, khatello ea mali, botena, ho tsuba, ho tsofala)

Ka letsatsi la pele - Letlapa le le leng le nang le 150 mg ea acetylsalicylic acid, joale letlapa le le leng le nang le 75 mg ea acetylsalicylic acid.

Thibelo ea infroction ea myocardial le thrombosis ea mali

Letlapa le le leng le nang le 75 mg kapa 150 mg ea acetylsalicylic acid.

Letlapa le le leng le nang le 75 mg kapa 150 mg ea acetylsalicylic acid.

Thibelo ea thromboembolism ka mora ho buuoa ka methapo (e.g. coronary artery bypass grafting, percutaneous translateuminal coronary angioplasty)

Letlapa le le leng le nang le 75 mg kapa 150 mg ea acetylsalicylic acid.

Haeba u fetoa ke tekanyetso e le 'ngoe kapa tse' maloa tsa moriana oa ThromboMag, u lokela ho nka tekanyetso e lahlehileng ea lithethefatsi hang hang ha mokuli a hopola sena. Ho qoba ho habanya lethal dose, ha ua lokela ho nka letlapa le lahlehileng haeba nako ea ho nka tekanyetso e latelang e ntse e atamela.

Mekhoa e ikhethang ea ts'ebetso nakong ea tsamaiso ea pele kapa ho khaotsa ha moriana ha ea ka ea bonoa.

Ketso ea pharmacological

Mochine oa ts'ebetso ea antiplatelet ea acetylsalicylic acid (ASA) o thehiloe ho thibelo e ke keng ea fetoloa ea cycloo oxygenase enzyme (COX-1), ka lebaka la hore syntomboxane A2 synthet e koetsoe mme pokello ea liplatelese e hatelletsoe.

Tlatsetso ea anti-aggregation e boleloa haholo liplatelete, kaha ha ba khone ho etsa COX e nchafatsang. Ho lumeloa hore ASA e na le mekhoa e meng ea ho hatella ho kopanya liplatelete, e atolosang boholo ba eona ho mafu a fapaneng a methapo. ASA e boetse e na le litlamorao tsa anti-inflammatory, antipyretic le analgesic.

Magnesium hydroxide - antacid, e fokotsa phello e halefisang ea ASA ho mucosa ea gastric.

Bokhachane le pelehi

Ts'ebeliso ea li-salicylates ka tekanyetso e phahameng ho trimester ea pele ea bokhachane e amahanngoa le khafetsa khafetsa ea bofokoli ba nts'etsopele ea fetal (ho petsoha hoa mala a ka holimo, bofokoli ba pelo). Tšebeliso ea lithethefatsi ho "trimester" ea pele ea bokhachane e tiisitsoe. Karolong ea bobeli ea bokhachane, moriana o ka fuoa feela ho latela tlhahlobo e tsitsitseng ea melemo ea kalafo ho mme le monyetla oa ho ba le kotsi ho lesea, ka tekanyetso e sa feteng 150 mg / letsatsi ka nako e khuts'oane. Karolong ea boraro ea kemolo, li-salicylates ka tekanyetso e phahameng (tse fetang 300 mg / letsatsi) li baka tšitiso ea pelehi, ho koaloa kapele ha methapo ka mpeng, ho eketseha ha mali ho mme le ka popelong, 'me ho e sebelisa pele ho tsoalo ho ka baka ho ruruha ha methapo pele ho nako. Tšebeliso ea lithethefatsi ho "trimester" ea boraro ea bokhachane e hapuoe.

Li-salicylates le li-metabolites tsa tsona ka tekanyo e nyane li fetela lebeseng la matsoele. Lintlha tsa kliniki ea ho hlahloba polokeho ea asiti ea acetylsalicylic nakong ea ho anyesa ha e lekane. Pele o fana ka asiti ea acetylsalicylic nakong ea lebone, melemo e lekantsoeng ea kalafo ea lithethefatsi le kotsi e ka bang teng ho masea e lokela ho hlahlojoa. Ho ja ka mokhoa o sa sebetseng oa li-salicylates nakong ea lebone ho sa tsamaeeng le nts'etsopele ea maikutlo a mabe ka ho ngoana mme ha ho hloke ho felisoa ha letsoele. Leha ho le joalo, haeba u hloka tšebeliso ea lithethefatsi ka nako e telele, ho anyesa ho lokela ho emisoa hanghang.

Tlhophiso ea Nosological (ICD-10)

Tekanyetso le tsamaiso

Ka hare Lihora tse 1-2 kamora lijo, nako e le 'ngoe ka letsatsi.

Letlapa la TromboMag ® litokisetso li entsoe li felile (li ka hlafuna kapa tsa silakanngoa), tsa hlatsuoa ka metsi.

TromboMag ® ea lithethefatsi e etselitsoe tšebeliso ea nako e telele. Nako ea kalafo e khethoa ke ngaka.

Thibelo ea mantlha ea mafu a pelo le methapo ea pelo, joalo ka ha ho na le lintho tse ka bang kotsi (mohlala, lefu la tsoekere, hyperlipidemia, khatello ea mali, botena, ho tsuba, ho tsofala). Ka letsatsi la pele - 1 tafoleng. Litokisetso tsa ThromboMag ® tse nang le 150 mg ea acetylsalicylic acid, joale - 1 tafoleng. ThromboMag ® e nang le 75 mg ea acetylsalicylic acid.

Thibelo ea khafetsa myocardial infarction le methapo ea mali. 1 tab. ThromboMag ® e nang le 75 kapa 150 mg ea acetylsalicylic acid.

Angina pectoris: 1 tab. ThromboMag ® e nang le 75 kapa 150 mg ea acetylsalicylic acid.

Thibelo ea ts'ebetso ea thromboembolism ka mora ho buuoa ka methapo (e.g. coronary artery bypass grafting, percutaneous translateuminal coronary angioplasty). 1 tab. ThromboMag ® e nang le 75 kapa 150 mg ea acetylsalicylic acid.

Ha u tlola tekanyetso e le 'ngoe kapa tse' maloa tsa tokisetso ea TromboMag ®, hoa hlokahala ho nka tekanyetso e lahlehileng ea moriana hang hoba mokuli a hopole sena. Ho qoba ho habanya lethal dose, ha ua lokela ho nka letlapa le lahlehileng haeba nako ea ho nka tekanyetso e latelang e ntse e atamela.

Mekhoa e ikhethang ea ts'ebetso nakong ea tsamaiso ea pele kapa ho khaotsa ha moriana ha ea ka ea bonoa.

Fomu ea tokollo

Letlapa le koahetsoeng ka lifilimi 75 mg + 15.2 mg kapa 150 mg + 30.39 mg. 10 tab. ka pokello ea lithupa e entsoe ka foil ea aluminium e hatisitsoeng le foil ea aluminium, lamunu ea PVC le filimi ea polyamide. Marang-rang a 3 kapa a 10 a behiloe ka har'a pakete ea karete.

Moetsi

Hemofarm LLC, Russia. 249030, Setereke sa Kaluga, Obninsk, Kievskoye sh., 62.

Mohala: (48439) 90-500, fekse: (48439) 90-525.

Lebitso le aterese ea mokhatlo oa molao eo lengolo la ngoliso / mokhatlo le amohelang likopo li fanoeng ka lebitso la hae. Nizhpharm JSC, Russia, 603950, Nizhny Novgorod, GSP-459, ul. Salgan, 7.

Mohala: (831) 278-80-88, fax: (831) 430-72-28.

Mofumahali

Hang ha e le pampitšana ea mala, ASA e kenngoa ka potlako mme e batla e felletse. Ka ho kenella ka nako e tšoanang, ho kenngoa hoa lieha. E na le metabolism e fokolang nakong ea ho monya.

Nakong ea ho monya le ka mor'a ho kenngoa, ASA e kenngoa ka biotransformed ho metabolite ea mantlha - salicylic acid, e boetse e tšeloa ka metsoako ea ts'usumetso ea enzyme (haholo-holo ka har'a sebete), e hlahisang ho thehoa ha metabolites joalo ka salicylic acid, glucuronide salicylate le phenyl salate, e fumanoang metsing a mangata a mmele le li-tishu. Ho basali, metabolism ea ASA e tsamaea butle (ka lebaka la ts'ebetso e tlase ea li-enzyme serum).

Palo e phahameng ea plasma ea ASA e fihlelloa metsotso e 10 - 20 kamora ho nka ThromboMag ka molomo, asiti ea salicylic - kamora metsotso e 18-120. Li-acetylsalicylic le salicelic acid li tlameletsoe liprotheine tsa plasma ka bongata 'me li fetisoa ka potlako' meleng. Ho tlangoa ha salicylic acid ho liprotheine tsa plasma ha se mela mme ho itšetlehile ka mohopolo. Maemong a tlase haholo (0,4 mg / ml) - ho fihla ho 75%.

Bioavailability ea acetylsalicylic acid ke 50-68%, salicylic acid - 80-100%. Asene e nang le letsoai le eona e tšela sethala sa placental ebe e kena lebeseng la matsoele.

Ho masea a sa tsoa tsoaloa, basali ba bakhachane le bakuli ba nang le bothata ba ho phekoloa ke lefu la masapo, salicylates e ka tlosa bilirubin ho kopaneng le albin mme ea baka kholo ea bilirubin encephalopathy.

ASA le metabolites ea eona li hlahisoa haholo ke liphio. Ha u nka ThromboMag ka tekanyetso e tlase, halofo ea bophelo (T_½) plasma acetylsalicylic acid ke 15-20 min, acid e salicylic ke 120-180 min. Ha o nooa moriana o noang tekanyetso e phahameng ka lebaka la tsamaiso ea methapo e bitsoang T_½ eketseha haholo.

Ho fapana le li-salicylates tse ling, ASA e se nang hydrolyzed, ha e nkuoa khafetsa, ha e bokelle serum ea mali. Ka ts'ebetso e tloaelehileng ea renal, 80-100% ea lethal dose le amoheloang la ASA e ntšoa ke liphio nakong ea lihora tse 24-72.

Hydroxide eo e leng karolo ea ThromboMag magnesium ha e ame bioavailability ea ASA.

Ho sebelisana le lithethefatsi

Matla a antiplatelet a ASA a fokotsoa ke: colestyramine, ibuprofen, systemic glucocorticosteroids le antacids tse nang le magnesium le / kapa aluminium hydroxide.

ASA e ntlafatsa sephetho mme e eketsa kotsi ea ho ba le chefo ha e sebelisoa ka nako e le 'ngoe le methotrexate (e fokotsa ho hlaka ha eona le ho e tlosa liprotheineng tsa plasma tsa mali) le asiti ea valproic (e e tlosa ka har'a protheine ea plasma).

Joalo ka li-NSAID tse ling, ka tekanyetso e phahameng, ASA e ka fokotsa phello ea hypurerase (e thibelang ho kopana ha li-prostaglandins tsa renal le ho fokotsa sekhahla sa filtration glomerular) le lithethefatsi tse antihypertensive. Haholo-holo, ka lebaka la tlholisano ea "block" ea "prostacyclin", lithethefatsi li ka fokotsa phello ea li-inhibitors tsa angiotensin.

Bakeng sa tekanyetso e tlase, ASA e nyenyefatsa phello ea li-uricosuric agents (sulfinpyrazone, probenecid, benzbromarone), ka tlholisano e thibela renal tubular excretion ea uric acid.

ASA e ntlafatsa sephetho mme e eketsa kotsi ea litlamorao tsa lithethefatsi tse latelang:

• li-NSAID tse ling le li-analgesics tsa narcotic (ka lebaka la ts'ebetso ea ts'ebelisano),
• carbonic anhydrase inhibitors, mohlala, acetazolamide (nts'etsopele ea acidosis e matla le litlamorao tse matla tsa chefo tsamaisong ea methapo ea kutlo li ka etsahala),
• digoxin le lithium (tlhahiso ea tsona ea renal e fokotseha, likhahla tsa plasma lia eketseha, ho tsepamisa mohopolo oa plasma ho lokela ho beoa leihlo le phetoho ea li-need),
• selefounu e khethiloeng ea li-serotonin reuptake inhibitors, ho kenyelletsa paroxetine le sertraline (ka lebaka la li-synergies, ka kotsi e eketsehileng ea ho tsoa mali ho tsoa mokokotlong o ka holimo oa mpa),
• li-antiplatelet agents (ho kenyelletsa clopidogrel le dipyridamole), anticoagulants e sa tsejoeng (ho kenyeletsa ticlopidine le warfarin), heparin, lithethefatsi tsa thrombolytic (ka lebaka la ho putlama ha liprotheine tsa plasma le synergism ea litlamorao tse kholo tsa kalafo),
• basebeletsi ba hypoglycemic ba molomo, e leng lintho tse nkiloeng ho sulfonylurea, le insulin ASA ka tekanyetso e phahameng ea letsatsi le letsatsi (ho feta 2000 mg) ka boeona e na le thepa ea hypoglycemic, hape e tlosa liphihlelo tsa sulfonylurea tse tsoang khokahanong le liprotheine tsa plasma,
• sulfonamides, ho kenyelletsa Co-trimoxazole (ASA e li leleka hole le puisano le liprotheine tsa plasma le ho eketsa khatello ea mali ka plasma),
• ethanol (tšenyo ea eona e senyang mucous membrane ea sistimi ea lijo e matlafatsoa, ​​'me menyetla ea ho tsoa mali ka mpeng e eketseha).

Litšoantšiso tsa TromboMag ke: Cardiomagnyl, Thrombital, Thrombital Forte, Phasostable.

Matšoao a lithethefatsi

Prophylaxis ea mantlha ea mafu a pelo le methapo ea pelo e matla joalo ka mabaka a kotsi (mohlala, lefu la tsoekere, ho ferekana kelellong, ho tsuba, ho tsofala), thibelo ea myocardial infarction le thrombosis ea methapo ea mali, thibelo ea thromboembolism kamora ho buuoa ho kenella ha methapo ea methapo (coronary artery bypass grafting, percutaneous translateuminal coronary angioplasty), e sa tsitsang ea angina pectoris.

Melemo ea litekanyetso

Moriana o nooa ka molomo, lihora tse 1-2 ka mor'a lijo, 1 nako / letsatsi. Matlapa a lokela ho metsoa ka metsi. Haeba a lakatsa, letlapa le ka robeha ka halofo, chewing kapa pele ho fatše.

Setlhare sena se reretsoe tšebeliso ea nako e telele. Nako ea kalafo e khethoa ke ngaka.

Bakeng sa thibelo ea mantlha ea mafu a pelo le methapo ea pelo e hlobaetsang le maemo a kotsi (mohlala, lefu la tsoekere, hyperlipidemia, khatello ea mali ea methapo, botenya, ho tsuba, ho tsofala), 1 tab. litokisetso tse nang le asiti e nang le acetylsalicylic ka lethal dose ea 150 mg ka letsatsi la pele, ebe ke 1 tab. litokisetso tse nang le asiti ea acetylsalicylic ka lethal dose ea 75 mg 1 nako / letsatsi.

Bakeng sa thibelo ea "frequency myocardial infarction" le "methapo ea mali", 1 tab. litokisetso tse nang le asiti ea acetylsalicylic ka lethal dose ea 75-150 mg 1 nako / letsatsi.

Bakeng sa thibelo ea "thromboembolism" kamora ts'ebetso ea ho buoa ka likepe litokisetso tse nang le asiti ea acetylsalicylic ka lethal dose ea 75-150 mg 1 nako / letsatsi.

Ka angina e sa tsitsang, 1 tab. litokisetso tse nang le asiti ea acetylsalicylic ka lethal dose ea 75-150 mg 1 nako / letsatsi.

Haeba u lahleheloa ke tekanyetso e le 'ngoe ea lithethefatsi, u lokela ho nka tekanyetso e lahlehileng ea meriana hang hang ha mokuli a hopola sena. Ho qoba ho habanya lethal dose, ha ua lokela ho nka letlapa le lahlehileng haeba nako ea ho nka tekanyetso e latelang e ntse e atamela.

Mekhoa e makatsang ea ketso ea moriana ka tekanyetso ea pele kapa ho khaotsa ha moriana ha ea ka ea bonoa.

Litla-morao

Ka kakaretso, litokisetso tse nang le motsoako ona li mamelloa hantle.

Ho tloha tsamaisong ea methapo: hangata - hlooho ea hlooho, ho hloka boroko, ka seoelo - ho tsekela, ho otsela, ka seoelo - tinnitus, hemorrhage ea intracerebral.

Ho tsoa ho sistimi ea hemopoietic: khafetsa - ho eketseha ha mali, hangata - khaello ea mali, ho se sebetse hangata haholo - aplopic anemia, hypoprothrombinemia, thrombocytopenia, neutropenia, leukopenia, eosinophilia, agranulocytosis. Ho na le litlaleho tsa maemo a haemolysis le anemia ea hemolytic ho bakuli ba nang le khaello e matla ea glucose-6-phosphate dehydrogenase.

Ho tsoa ts'ebetsong ea phefumoloho: hangata - bronchospasm.

Ho tsoa ho ts'ebetso ea tšilo ea lijo: hangata khafetsa - ho otla ha pelo, hangata - ho nyekeloa, ho hlatsa, hangata - bohloko ka mpeng, ulcers ea mucous membrane ea mpa le duodenum, ho tsoa mali ka mpeng, ka seoelo - ho tlotsa ka mpeng kapa ka mpeng ea lesapo la mokokotlo, ts'ebetso e eketsehileng ea li-enzyme tsa sebete. , hangata seoelo - stomatitis, esophagitis, lores ea lisele tsa ka mpeng tsa ka mpeng (ho kenyeletsoa le litheko), colitis, lefu la masapo le bohale.

Litlamorao: khafetsa - urticaria, edema ea Quincke, lekhopho la letlalo, ho hlohlona, ​​rhinitis, ho ruruha ha mucosa ea nasal, ka seoelo - anaphylactic makala, lefu la pelo le khatello ea maikutlo.

Tse ling: ha li sebetse haholo - ts'ebetso ea mokokotlo e sa sebetseng.