Drops Amoxicillin: litaelo tsa tšebeliso

Amoxicillin: litaelo tsa tšebeliso le litlhahlobo

Lebitso la Latin: Amoxicillin

Khoutu ea ATX: J01CA04

Lintho tse sebetsang: amoxicillin (amoxicillin)

Mohlahisi: Biochemist, OJSC (Russia), Dalhimpharm (Russia), Organika, OJSC (Russia), STI-MED-SORB (Russia), Hemofarm (Serbia)

Nchafatso ea litlhaloso le setšoantšo: 11.26.2018

Litheko makaleng a litlhare: ho tloha li-ruble tse 30.

Amoxicillin ke lithethefatsi tse thibelang likokoana-hloko, e leng semisynthetic penicillin.

Sokolla foromo le sebopeho

Mefuta ea litekanyetso Amoxicillin:

matlapa: hoo e ka bang e tšoeu kapa e tšoeu, e sephara-cylindrical, e nang le mola o arohanang le chamfer (li-pcs tse 10 kapa li-pcs tse 20. ka marang-rang, ka lebokoseng la karete ea 1, 2, 5, 10, 50 kapa 100, liphutheloana tse 24. linkho tsa khalase e 'mala o lefifi, ka lebokoseng la karete e le ngoe ea 1, li-pcs tse 20. ka har'a makotikoti a polymer kapa libotlolong, ka lebokoseng la karete ea 1 can kapa botlolo),
li-capsules: gelatinous, ka tekanyo ea 250 mg - boholo No 2, e nang le cap e ntšo e putsoa le e tšoeu e nang le 'mele o moputsoa, ka tekanyo ea 500 mg - boholo ba No 0, e nang le cap e khubelu le' mele o mosehla, kahare ho lipilisi ke phofo ea granular e nang le 'mala o tsoang ho 'mala o mosehla ho o mosoeu, ho putlama ha eona ho lumelletsoe (250 mg ka' ngoe: li-pcs tse 8. ka lithutsoana, likhaketeng tse 2 tsa likharafu, li-pcs tse 10 ka har'a lithutsoana, ka pakete ea 1 kapa 2 ea liphutheloana, 10 kapa 20 likhomphutha). ka lekeseng, lebokoseng la karete e 1, 500 mg ka 'ngoe: likhomphutha tse 8. ka lithutsoana, likhaketeng tse 2 tsa karete, 2 likhomphutha. urnyh blister ka sephutheloana lebokoso 1 kapa sephutheloana 2, 10 likhomphutha. ka machachetsi ka lebokose lebokose 1, 2, 50 kapa 100 dipakete)
li-granules bakeng sa ho emisoa ka molomo: phofo ea granular ho tloha e tšoeu e nang le tint e 'mala o mosoeu, ka mor'a ho qhibiliha ka metsing - ho emisoa ka' mala o mosehla le monko oa litholoana (40 g e ngoe le e ngoe ka libotlolong tsa khalase tse lefifi tse nang le matla a 100 ml, ka lebokoseng la lebokose le le leng 1 ka khaba ea ho lekanya e nang le likarohano tsa 2,5 ml le 5 ml).

Letlapa le le leng le na le:

ntho e sebetsang: amoxicillin trihydrate (ho ea ka amoxicillin) - 250 mg kapa 500 mg,
likarolo tse thusang: setapole sa litapole, furu ea magnesium, polysorbate-80 (pakeng tsa 80), talc.

1 capsule e na le:

ntho e sebetsang: amoxicillin trihydrate - 286.9 mg kapa 573.9 mg, e tsamaellanang le litaba tsa 250 mg kapa 500 mg ea amoxicillin,
likarolo tse thusang: microcrystalline cellulose PH 102, magnesium stearate, titanium dioxide (E171), gelatin.

Ntle le moo, e le karolo ea khetla ea capule:

boholo ba 2: cap - quinoline e dae (E104), indigo carmine (E132), joalo ka dae ea quinoline e (E104),
saese ea 0: cap - dae lero le chaba la letsatsi (E110), dae azorubine (E122), mmele - dae iron oxide e sootho (E172).

Ho 5 ml ea ho emisoa ho felileng (2 g ea granules) e na le:

ntho e sebetsang: amoxicillin trihydrate (ho ea ka amoxicillin) - 250 mg,
likarolo tse thusang: sodium saccharinate dihydrate, sucrose, simethicone S184, sodium benzoate, guar gum, sodium citrate dihydrate, fragola tatso, tatso ea raspberry, tatso e ratehang ea tsoekere.

Pharadodynamics

Amoxicillin ke penicillin e entsoeng ka metso e 'maloa, e leng antibacterial bactericidal acid e thibelang likokoana-hloko e nang le ts'ebetso e mengata. Mochine oa ts'ebetso o bakoa ke bokhoni ba amoxicillin ba ho baka lizing ea baktheria, e thibelang transpeptidase le ho sitisa motsoako oa protheine ea "cell protein" ea peptidoglycan nakong ea karohano le kholo.

Likokoana-hloko tse ntle tsa gram le gram-negative li bontša kutloelo-bohloko ea lithethefatsi.

Amoxicillin e sebetsa ho libaktheria tse latelang:

Baktheria e ntle ea gram e ntle: Corynebacterium speciales (spp.), Staphylococcus spp. (ntle le ha likokoana-hloko li hlahisa penicillinase), Bacillus anthracis, Listeria monocytogene, Enterococcus faecalis, Streptococcus spp. (ho kenyelletsa le Streptococcus pneumoniae),
libaktheria tsa aerobic gram-negative: Brucella spp., Bordetella pertussis, Shigella spp., Escherichia coli, Klebsiella spp.
Ba bang: Leptospira spp., Clostridium spp., Borrelia burgdorferi, Helicobacter pylori.

Likokoana-hloko tse hlahisang penicillinase le tse ling tsa beta-lactamase ha li amehe ka lithethefatsi, kaha beta-lactamase e senya amoxicillin.

Mofumahali

Kamora ho tsamaisoa ka molomo, amoxicillin e potlakile ebile e haufi le ho kenella ka botlalo (93%). Ho thipa ha ho amehe ka ho ja lijo tse ngata ka nako e le 'ngoe, lithethefatsi ha li senngoe tikolohong ea acid e ka mpeng. Khokahano e kholo e fihlelloa kamora lihora tsa 1-2 mme e fihla ho 0.0015-0.003 mg / ml ka mor'a tekanyetso ea 125 mg le 0.0035-0.005 mg / ml ka mor'a tekanyo ea 250 mg. Phello ea tleleniki e qala ho hola ka lihora tse 1 / 4-1 / 2 mme e nka lihora tse 8.

E na le palo e kholo ea mohala. Boemo ba mahloriso bo eketseha ka tekanyo ea tekanyetso ea moriana. Metsoako e phahameng ea amoxicillin e fumanoa maro a plasma, pleural le peritoneal fluid, sputum, bronchial secretions, lung le masapo a masapo, mucosa ea ka mpeng, moroto, tšoelesa ea senya, litho tsa botšehali tsa setho sa botšehali, lithane tsa tsebe, methapo ea tsebe e bohareng, le marotholi a letlalo. E kenella ka har'a "tisal" ea fetal, ka ts'ebetso e tloaelehileng ea sebete - ka har'a senya ea nyooko, moo litaba tsa eona li ka fetisang khatello ea plasma ka makhetlo a 2-5. Secretion ea purulent ea bronchi e tsamaisoa hampe. Ha e sebelisoa nakong ea bokhachane, litaba tsa amoxicillin ka har'a lijana tsa mokokotlo oa "umbilical fluid" ke 25-30% ea mahloriso a plasma ea mmele oa mosali.

Ka lebese la matsoele, ho tšeloa karolo e nyane. Tšitiso ea mali le mali ha e anngoe hantle, khatello ea mali mokelikeling ha u sebelisa amoxicillin bakeng sa kalafo ea meningitis (ho ruruha ha meninges) ha e fetang 20%.

Ho kopanya liprotheine tsa plasma - 17%.

E tšelisoa ka molumo o sa phethoang ka ho thehoa ha metabolites e sa sebetseng.

Half-life (T_1/2) ke lihora tse 1-1,5. 50-70% e pepesoa ka liphio li sa fetoha. Ho tsena, ka ho hlohlona ha glomerular - 20%, tubular excretion - 80%. 10-20% e epolloa ka mala.

T_1/2 bakeng sa ts'ebetso ea ho senyeha ha renal e nang le clearinine clearance (CC) ea 15 ml / min kapa ka tlase, e nyolohela ho lihora tse 8,5.

Ka hemodialysis, amoxicillin e tlosoa.

Matšoao a ho sebelisoa

Ho ea ka litaelo, Amoxicillin e bontšoa bakeng sa kalafo ea mafu a tšoaetsanoang le a tšoaetsanoang a bakoang ke likokoana-hloko tse qalang:

tšoaetso ea phepelo ea pampiri ea phefumoloho - letheba le ruruhileng, ho mpefala ha bronchitis e sa foleng, bronchopneumonia, lobar pneumonia,
ts'oaetso ea litho tsa ENT - sinusitis, tonsillitis, pharyngitis, mecha ea litaba ea otitis,
ts'oaetso ea letlalo le lisele tse bonolo - li-dermatoses tse tšoaelitsoeng, li-erysipelas, impetigo,
ts'oaetso ea genitourinary system - cystitis, pyelonephritis, urethritis, gonorrhea,
mafu a gynecological - endometritis, cervicitis,
ts'oaetso ea mala - typhoid fever, paratyphoid fever, shigellosis (dysentery), salmonellosis, salmonella koloing,
ulceric ulcer ea mala le duodenum (e le karolo ea kalafo e kopaneng),
tšoaetso ea ka mpeng - enterocolitis, peritonitis, cholecystitis, cholangitis,
tshwaetso ya meningococcal,
listeriosis (mofuta o boima le oa morao-rao),
leptospirosis,
Borreliosis (lefu la Lyme)
sepsis
endocarditis (thibelo nakong ea ho kenella ha meno le tšebetso tse ling tse nyane).

Contraindication

ho hloleha ha sebete
asthma ea lefu la bronchial,
hay fever
lymphocytic leukemia
tšoaetso ea mononucleosis,
colitis ka lebaka la ho nka lithibela-mafu (ho kenyeletsa nalane ea bongaka),
sefuba
hypersensitivity ho lithibela-mafu tsa beta-lactam, ho kenyeletsoa penicillin, cephalosporins, carbapenems,
ho se mamellane ha motho ka mong likarolo tsa moriana.

Litlatsetso tse ling tsa mefuta e meng ea amoxicillin:

matlapa: mafu a kulang (ho kenyeletsa nalane ea bongaka), lilemo tse ho fihlela lilemo tse 10 ka boima ba 'mele bo ka tlase ho 40,
li-capsules: atopic dermatitis, nalane ea maloetse a amanang le lefu la ka mpeng, a ho fihlela lilemo tse 5,
li-granules: glucose-galactose malabsorption syndrome, khaello ea sucrose (isomaltase), ho se mamellehe ha fructose, atopic dermatitis, nalane ea maloetse a amanang le gastrointestinal.

Ka hloko, ho khothalletsoa hore Amoxicillin e ngoletsoe bakuli ba nang le bothata ba ho phekoloa ke methapo, nalane ea ho tsoa mali, e tloaelo ho ntlafatsoa ke lintho tse amang (ho kenyeletsa nalane), nakong ea kemero.

Ntle le moo, tlhokomeliso e lokela ho sebelisoa ha ho sebelisoa litafole bakeng sa kalafo ea bakuli ba nang le nalane ea mafu a ka mpeng.

Litlamorao

ho tsoa ho tšilo ea lijo: tlolo ea tatso ea tatso, ho nyekeloa ke pelo, ho hlatsa, dysbiosis, lets'ollo, lefu la mokokotlo, pseudomembranous colitis, glossitis, ho senyeha ha sebete, ts'ebetso e eketsehileng ea transaminase tse nang le phepo e matla, cholestatic jaundice, acute cytolytic hepatitis,
ho tloha ts'ebetsong ea methapo: ho hloka boroko, ho ruruha, hlooho e bohloko, ho tšoenyeha, pherekano, ho tsekela, ho tšaba, ho fetoha ha boitšoaro, ho ruruha ha maikutlo, khatello ea maikutlo, karabelo e kholisang,
kulisa: feberu, urticaria, Flushing tsa letlalo, rhinitis, conjunctivitis, etymology, eosinophilia, angioneurotic edema, bohloko manonyeletso, exfoliative dermatitis, Stevens - Johnson poliformnaya (multiforme) etymology, alejiki vasculitis, anaphylactic liphetoho makala tšoanang bokuli ba serum
paramethara ea laboratori: neutropenia, leukopenia, agranulocytosis, anemia, thrombocytopenic purpura,
ho tsoa ho ts'ebetsong ea urine: crystalluria, nephritis ea mahareng
ba bang: tachycardia, ho hema hanyane, ho hlasela ka botšehaling, ho hlahella ka ho eketsehileng (hangata khafetsa kalafong ea ts'oaetso e sa foleng kapa ho bakuli ba nang le khatello ea mmele e fokotsang).

Ntle le moo, ho a khonahala ho hlahisa litla-morao tse latelang tse tlalehiloeng ha u nka mefuta e meng ea Amoxicillin:

matlapa: ho haptjoa ke lintho tse sa tloaelehang ka tsela ea lekhopho la letlalo, ho hlohlona, chefo e kotsi ea lietsahala, pustulosis e akaretsang, hepatic cholestasis, eosinophilia,
lilakane: molomo o ommeng, leleme le moriri o moputsoa, licidiasis tsa letlalo le membrane ea mucous, keketseho ea nako ea prothrombin le nako ea ho kopana ha mali, letheba la enamel ea leino ka 'mala o mosehla, o sootho kapa o moputsoa,
granules: "Letsoho le lesoeu" leleme, ho fifatsa ha enamel ea leino, hemolytic anemia, haholo pustulosis e matla.

Litaelo tse khethehileng

Ho khethoa ha Amoxicillin ho ka etsahala hafeela ho se na sesupo nalaneng e qaqileng ea mokuli ea sa tsotelleng karabelo ea lithibela-mafu tsa beta-lactam (ho kenyeletsa penicillin, cephalosporins). Bakeng sa merero ea prophylactic, ho bontšoa taolo e tšoanang ea li-antihistamines.

Ha u sebelisa lithibela-mafu tsa molomo tsa estrogen tse nang le estrogen, basali ba lokela ho eletsoa ho eketsa mekhoa ea thibelo ea bokhachane nakong ea kalafo le amoxicillin.

Ka phekolo e kopanetsoeng ea anticoagulant, ho lokela ho nahanoa ka phokotso ea litekanyetso tsa bona.

Ts'ebeliso ea lithibela-mafu ha e na thuso kalafong ea tšoaetso ea vaerase e matla haholo.

Amoxicillin ha ea lokela ho laeloa bakeng sa kalafo ea mononucleosis e tšoaetsanoang ka lebaka la kotsi ea ho ba le leqeba la letlalo la erythematous le ho mpefatsa matšoao a lefu lena.

Ha ho kgothaletswe ho sebelisa mefuta ea molomo ea amoxicillin bakeng sa kalafo ea bakuli ba nang le mafu a methapo ea ka mpeng, e tsamaeang le lets'ollo le ho hlatsa kamehla.

Haeba lets'ollo le bobebe le etsahala ha o ntse o nka amoxicillin, o ka sebelisa li-antidiarrheal agents tse nang kaolin kapa attapulgite, o qoba ho nka lithethefatsi tse tsamaeang butle ka mpeng.

Haeba ho na le lets'ollo le matla le nang le metsi, setuloana se metsi a 'mala o botala le monko oa pungent, ho kenyelletsa motsoako oa mali o tsamaeang le feberu le bohloko bo boholo ba ka mpeng, o lokela ho etela ngaka hang-hang. Matšoao ana a ka bonts'a phepelo e matla ea kalafo ea lithibela-mafu ka mofuta oa nts'etsopele ea clostridiosis pseudomembranous colitis.

Bokhachane le pelehi

Nakong ea kemaro, tšebeliso ea Amoxicillin e ka etsahala ha feela kalafo e lebelletsoeng ea kalafo ho mme, ho latela ngaka, e feta ts'okelo e ka hlahang ho lesea.

Ts'ebeliso ea moriana nakong ea lebone e emisitsoe. Haeba ho hlokahala ho fana ka amoxicillin, letsoele le lokela ho emisoa.

Haeba ho na le bothata ba ho renal bo sa sebetseng

Ka hlokolosi, Amoxicillin e lokela ho sebelisoa ho phekola bakuli ba nang le bothata ba ho phekoloa ke methapo.

Mokhoa o tloaelehileng oa litekanyetso bakeng sa litafole le granules o sebelisoa ho bakuli ba nang le CC ka holimo ho 40 ml / min, bakeng sa likhabapo tse nang le CC tse kholo ho feta 30 ml / min.

Ka ho senyeha haholo ha renal, ho hlokahala hore ho fetoloe tokiso ea lethal dose. E hlahisoa ka ho nahana ka CC ka ho fokotsa tekanyetso e le 'ngoe kapa ho eketsa karohano lipakeng tsa tekanyetso ea Amoxicillin.

Ka CC 15- 40ml / min, lethal dose le tloaelehileng le beuoe, empa sekhahla pakeng tsa litekanyetso li nyoloheloa ho lihora tse 12, mme CC e le tlase ho 10 ml / min, tekanyetso e lokela ho fokotsoa ke 15-50%.

Tekanyo e phahameng ea letsatsi le letsatsi ea Amoxicillin ho anuria ke 2000 mg.

Tabeng ea ho senyeha ha mosebetsi oa renal ho bana ba nang le CC ho feta 30 ml / min, khalemelo ea litekanyetso tsa litekanyetso ha e hlokehe. Ka CC ea 10-30 ml / min, bana ba fuoa 2/3 ea lethalino le tloaelehileng, ba eketsa nako ea lipakeng ho isa ho lihora tse 12. Ho bana ba nang le CC ka tlase ho 10 ml / min, khafetsa ea tsamaiso ea lithethefatsi ke nako e le 'ngoe ka letsatsi, kapa ba fuoa 1/3 ea lethal dose le tloaelehileng la bana.

Ho sebelisana le lithethefatsi

Ka tšebeliso e tšoanang ea amoxicillin:

ascorbic asiti: e baka keketseho ea tekanyo ea ho amoheloa ha moriana,
aminoglycosides, antacids, laxatives, glucosamine: thusa ho fokotsa le ho fokotsa ho monya,
ethanol: e fokotsa sekhahla sa ho amoheloa ha amoxicillin,
Digoxin: e eketsa monko,
probenecid, phenylbutazone, oxyphenbutazone, indomethacin, acetylsalicylic acid: e baka keketseho ea khatello ea amoxicillin maling a mali, e liehisa ho felisoa ha eona,
methotrexate: menyetla ea ho ba le chefo ea methotrexate e eketsehile.
anticoagulants le lithethefatsi ka tsela e sa tobang nakong ea metabolism eo ho eona ho entsoeng ka para-aminobenzoic: khahlano le nalane ea ho fokotseha ha motsoako oa vithamine K le index ea prothrombin ka lebaka la khatello ea "microflora" ea "intestinal" e hlahisoang ke kotsi ea kotsi ea ho phatloha ha mali ka bongata.
allopurinol: e eketsa menyetla ea ho ba le mathata ohle a letlalo,
lithibela-pelehi tsa molomo: ho kenyelletsa botšehali ba estrogens ka mpeng, bo lebisa ho fokotsehang hoa katleho ea thibelo ea bokhachane,
lithibela-mafu tse thibelang likokoana-hloko (cycloserine, vancomycin, aminoglycosides, cephalosporins, rifampicin): bakang litlamorao tsa antibacterial,
lithethefatsi tsa bacteriostatic (sulfonamides, macrolides, lincosamides, chloramphenicol, tetracyclines): li thusa ho fokolisa phello ea bactericidal ea amoxicillin,
metronidazole: ts'ebetso ea antibacterial ea amoxicillin e eketseha.

Li-analogues tsa Amoxicillin ke: matlapa - Amoxicillin Sandoz, Ecobol, Flemoxin Solutab, Ospamox, li-capsule - Hiconcil, Amosin, Ampioks, Hikontsil, Ampicillin Trihydrate.