Atorvastatin-Teva e hlahisoa ka mokhoa oa matlapa a koahetsoeng ka filimi e koahelang: e entsoe ka selikalikoe, se batlang se le sesoeu kapa se tšoeu, se ngotsoe "93" ka lehlakoreng le leng, 'me ho ngotsoe "" 7310 "bakeng sa 10 mg, le 7310 bakeng sa 20 mg "7311", bakeng sa 40 mg - "7312", bakeng sa 80 mg - "7313" (li-pcs tse 10. Ka marang-rang, ka lebokoseng la karete ea lilakane tsa 3 kapa 9).

Letlapa la 1

• ntho e sebetsang: calcium atorvastatin - 10,36, 20,72, 41.44 kapa 82.88 mg, e lekanang le 10, 20, 40 kapa 80 mg ea atorvastatin,
• likarolo tse ling: povidone, lactose monohydrate, eudragit (E100) (methyl methacrylate, butyl methacrylate le dimethylaminoethyl methacrylate Copolymer), sodium stearyl fumarate, croscarmellose sodium, alpha-tocopherol macrogol,
• Coating ea lifilimi: opadry YS-1R-7003 hypromellose 2910 3cP (E464), polysorbate 80, hypromellose 2910 5cP (E464), macrogol 400, titanium diode.

Matšoao a ho sebelisoa

• heterozygous hypercholesterolemia ea heterozygous ea setho sa lelapa, hypercholesterolemia e tsoakiloeng (e kopantsoeng) hyperlipidemia (mefuta ea IIa le IIb ho latela sehlopha sa Fredrickson) - hammoho le lijo tse fokotsang lipid tse etselitsoeng ho theola maemo a phahameng a cholesterol, cholesterol e tlaase-tlaase le cholesterol e tlase. hammoho le ho eketsa palo e phahameng ea letsoalo la lipoprotein cholesterol (HDL),
• homozygous Famer hypercholesterolemia - e le ho fokotsa cholesterol e felletseng le LDL cholesterol, ka ho se sebetse hantle ka botlalo kalafong ea ho ja le mekhoa e meng eo e seng ea bongaka ea kalafo.
• mofuta o phahameng oa serum triglycerides (mofuta oa IV ho latela sehlopha sa Fredrickson) dysbetalipoproteinemia (mofuta oa III ho latela sehlopha sa Fredrickson) - maemong a kalafo a sa sebetseng.

Contraindication

• ho ima le ho nyekeloa,
• lilemo ho isa ho lilemo tse 18 (profil ea ts'ireletso ea atorvastatin ho bana le bacha ha e so ithutoe),
• mafu a sebete a sebetsang, keketseho ea tšebetso ea li-enzyme tsa sebete tsa tlhaho e sa tsejoeng, e fetang moeli o kaholimo oa e tloaelehileng (VGN) ka makhetlo a fetang a 3,
• ho hloleha ha sebete (lihlopha tsa bana le bana tsa B),
• hypersensitivity ho likarolo tsa moriana.

Moratuoa (ho hlokahala hore a sebelise sehlahisoa ka hloko):

• mathata a endocrine le metabolic,
• phatlalatsa ho hloka toka ha electrolyte,
• hypotension
• nalane ea lefu la sebete,
• lefu la sethoathoa le sa laoleheng,
• mafu a hlobaetsang haholo (ho kenyeletsa le sepsis),
• marapo a marapo a marapo
• likotsi, lingaka tse ngata tse buoang,
• bokhoba ba joala.

Tekanyetso le tsamaiso

Atorvastatin-Teva e sebelisoa ka molomo, nako e le 1 ka letsatsi. Ho ja ha ho ame katleho ea moriana.

Tekanyetso ea pele, joalo ka molao, ke 10 mg, matlapa a nooa neng kapa neng ka letsatsi. Litekanyetso li khethoa ke ngaka ka bonngoe, ho latela boemo ba cholesterol ea pele, sepheo sa kalafo le karabelo ea mokuli kalafong. Tekanyetso ea letsatsi le letsatsi e ka fapana ho tloha ho 10 ho isa ho 80 mg, e lokela ho lokisoa nako le nako ea libeke tse 4 kapa ho feta. Tekanyo e phahameng ea letsatsi le letsatsi ha ea lokela ho feta 80 mg.

Nakong ea kalafo, ka keketseho ea lethal dose, ho hlokahala libeke tse ling le tse ling tse 2 ho beha leihlo lipilisi tsa plasma, 'me ho ipapisitsoe le data e fumanoeng.

Tekanyetso e khothalletsoang:

• homozygous Famer hypercholesterolemia: 80 mg ka letsatsi,
• heterozygous Familyal hypercholesterolemia: qalong ea thupelo, nka 10 mg ka letsatsi, nakong ea phekolo ka mor'a libeke tse ling le tse ling tse 4 e fihla, e tlisa ho 40 mg ka letsatsi, e fumanoang hammoho le sequestrant ea bile acid, ka atorvastatin e le sethethefatsi sa monotherapy, tekanyo e ka eketsoa ho ea holimo boleng - 80 mg ka letsatsi,
• hypercholesterolemia ea mantlha le hyperlipidemia e tsoakiloeng: nka 10 mg ka letsatsi, lethal dose lena ho bakuli ba bangata le u lumella ho fana ka taolo e hlokahalang ea maemo a lipid, joalo ka molao, phello e matla ea kalafo e bonoa libeke tse 4 kamora ho qala taolo mme e nka nako e telele e sebelisa moriana.

Boteng ba ho hloleha ha sebete, haeba ho hlokahala, lethal dose la Atorvastatin-Teva le ka fokotsoa kapa kamohelo ea lona e hlakotsoe. Bakeng sa bakuli ba nang le lefu la liphio, ho lokisoa ha lethalamo ha ho hlokehe.

Bakeng sa lefu la pelo le hlahileng kapa kotsi e kholo ea mathata a pelo, ho khothalletsoa hore phekolo e etsoe le lipheo tse latelang tsa khalemelo ea lipid: kakaretso ea cholesterol Eketsetse taba ena:

Sebopeho le mofuta oa tokollo

Ho latela tlhahisoleseling e fanoeng ke radar, Atorvastatin Teva ke moemeli oa lithethefatsi tsa sehlopha sa li-statins. Lithethefatsi li na le tšusumetso e tobileng ho fokotseha ha enzyme, eo ho eona e leng thibelo. Setlhare se fumaneha ka sebopeho sa letlapa, se koahetsoeng ka khetla ho tsoa ho filimi e khethehileng, e fang sehlahisoa 'mala o mosoeu.

E sebetsa karolo e sebetsang Teor ea Atorvastatin - Atorvastatin calcium calcium. Ho ipapisitse le khatello ea ntho e sebetsang, lipilisi li na le litekanyetso tsa 21.7 kapa 10,85 mg. Haeba u fetisetsa atorvastatin ke 20 le 10 mg, ka ho latellana.

Ntle le ntho ea mantlha e etsang mosebetsi oa pholiso, letlapa le leng le le leng le na le likarolo tse itseng tsa lintho tse thusang. Tsena li kenyeletsa: calcium carbonate, dae ea opadray, stearate ea magnesium, selulose, starch. Moetsi o kenya moriana ka mekotleng ea blister le ka lebokoseng la karete.

Litlamorao

Boholo ba bakuli ba fumanang kalafo e kopaneng le ho kenyelletsoa ha Atorvastatin-Teva, ba boletse mamello ea eona e ntle. Ho sa tsotelehe sena, joalo ka eng kapa eng, sethethefatsi sena se na le litla-morao. Ka tšilo ea lijo mathata a dyspeptic (lets'ollo kapa ho sokela, ho otla ha pelo, ho nyekeloa, ho hlatsa, ho lofa), leseling la ka mpeng le mala, mafu a ka mpeng a manyeme, mpeng ho ka hlaha.

Ka litho tsa motsamao e ka ba le myositis, myalgia, arthralgia, myopathy, rhabdomyolysis. Atopvastatin-induction myopathy e ka rarahanngoa ke ho se sebetse hantle ha bohloko ka lebaka la myoglobinuria (tlhahiso ea lihlahisoa tse senyehileng tsa mesifa mokokotlong).

Ho tloaelehile haholo hore sethethefatsi se baka liponahatso tsa mmele (urticaria, edema ea Quincke, dermatitis, lesapo la letlalo la erythematous).

Ka linako tse ling hoa khoneha ho sitisoa ke kelello, matlafatso ea 'mele, ho robala hamonate le ho falimeha, litšitiso tsa pono kapa maikutlo.

Litaelo tsa ho sebelisoa

Pele o qala ho nka Teorvastatin Teva, ntle le mokhelo, bakuli bohle ba hloka lijo tse tloaelehileng tsa hypocholesterol. Molao-motheo ona oa phepo ha oa lokela ho bonoa eseng feela khahlano le kalafo ea lithethefatsi, empa hape le bophelong bohle. Mokhoa ona o tla thusa ho fihlela sepheo sa mantlha sa phekolo - LDL le cholesterol e felletseng e tla fihlela litekanyetso tse tloaelehileng, mme boemo ba HDL bo tla eketseha.

Teva ea Atorvastatin e ka nooa ho sa tsotelehe nako ea lijo. Ho qala kalafo, o hloka ho lekola khoeli le khoeli profid ea lipid e le hore u khethe le ho latela tekanyo ea moriana.

Motsoako oa ho qala hangata ha o fetele 10 mg ea atorvastatin ka letsatsi. Ha ho hlokahala, ho ka khona ho tlisa lethalamo le phahameng la 80 mg ka letsatsi, le ka arohanang ka litekanyetso tse peli (hoseng le mantsiboea). Haeba mokuli a phekoloa ka nako e tšoanang ka cyclosporiomas, litekanyetso tsa letsatsi le letsatsi tsa Atorvastatin Teva e lokela ho ba bonyane (10 mg ka letsatsi). Keketseho ea khatello ea atorvastatin ho plasma ea mali (hammoho le liphetoho tse ntle boleng ba likaroloana tsa lipid tse potolohang) e bontšoa matsatsi a 10-14 ka mor'a ho qala ha kalafo.

Sebelisa nakong ea bokhachane

Bokhachane ke boemo ba 'mele ba mosali eo ho bona Atorvastatin Teva e haneloang ka molao. Tšebeliso ea lithethefatsi e ka etsahala feela ha molemo ho 'm'a o feta kotsi ho mojalefa ea e-so hlahe. Ka lebaka la ho haella ha tlhaiso-leseling ea tlhahlobo ea bongaka ea hore na Atorvastatin Teva e fetela lebese la matsoele, ho thibetsoe ho e nka ha e feptjoa ka tlhaho. Haeba kalafo ka atorvastatin e hlokahala, lactation e lokela ho khaotsa.

Haeba moemeli oa bong bo nepahetseng a ithutile ka boimana ba hae, kaha o se a qalile kalafo le Atorvastatin Teva, ho amoheloa ha hae ho lokela ho emisoa kapele kamoo ho ka khonehang. Basali ba noang meriana ena ba tlameha ho hlokomela mekhoa e tšepahalang ea ho itšireletsa khahlanong le moimana oa ngoana. Basali ba lilemo tsa ho ba le bana, pele ba qala kalafo le Atorvastatin Teva, ho bohlokoa ho fumana tumellano le gynecologist.

Ts'ebeliso ea Atorvastatin Teva ha e khothalletsoe molemong oa sehlopha sa batho ba ka tlase ho lilemo tse ngata. Sena se bakoa ke taba ea hore liteko tsa tleliniki mabapi le ts'ebetso le ts'ireletso ea lithethefatsi ho bana ha li e-so tšoaroe, ka hona lintlha tsa sena ha li fumanehe.

Ho sebelisana le lithethefatsi tse ling

Ho kenyelletsa litlamorao tse sa rateheng 'meleng, o lokela ho tseba hore na Atorvastatin Teva e sebetsana joang le lithethefatsi tse ling. Ka tšebeliso e le 'ngoe le lithethefatsi kahare tse nang le norethisterone le ethinyl estradiol (lithibela-pelehi tsa molomo), mahloriso a plasma ea lintho tsena tse sebetsang tsa li-hormone a eketseha haholo. Ketsahalo ena e lokela ho tsotelloa ha e fana ka thibelo ea bokhachane ba lihormone bakeng sa basali ba hlokang kalafo le Atorvastatin Teva.

Tšebelisano e sa rateheng le atorvastatin le li-statin tse ling li bonoa ho cyclosporine, lithethefatsi tsa antimycotic, li-antibacterial agents tse tsoang sehlopheng sa macrolide, le nicotinic acid. Tšebelisano e lumellanang le lintho tsena e eketsa haholo menyetla ea myopathy le mathata ohle a latelang (rhabdomyolysis, ho se sebetse hantle ha renal).

Ka tsamaiso e le 'ngoe ea Atorvastatin Teva e nang le digoxin, khatello ea "pelo" glycoside e plasma ea mali e eketsehile ha tekanyetso ea letsatsi le letsatsi ea statin e ne e le 80 mg. Ka hona, ho bakuli ba fumanang digoxin, molemong oa ho qoba ho tahoa glycoside, litekanyetso tsa "lipid" tse fokotsang lipilisi li lokela ho ba tlase ho 80 mg ka letsatsi.

Theko ea lithethefatsi

Ha o reka Atorvastatin Teva, theko e ipapisitse le litekanyetso tsa ntho e sebetsang, hammoho le marang-rang a litlama moo ho rekoang lithethefatsi. Leano la litheko tsa sethethefatsi sena ha le fapane haholo le litšenyehelo tsa lithethefatsi tse tšoanang ka ts'ebetso ea tsona.

• Tšimong Mokhatlo oa Russia Theko e bohareng ka pakete ea Atorvastatin Teva ke li-ruble tse 200.
• Seukraine pharmacy e fana ka lipilisi tsa 20 mg ka theko ea 250 UAH.

Li-analog tsa Atorvastatin-Teva

Likhamphani tsa morao-rao tsa meriana li fana ka ho reka li-analogu tsa Atorvastatin Teva tsa tlhahiso ea lapeng le kantle. Lithethefatsi tsena li fapana feela ka mabitso a khoebo, empa ho ea ka ntho e sebetsang e ts'oana hantle. Litšoantšo tse atileng haholo tsa Atorvastatin Teva ke Atoris, Liprimar, Tulip, Torvakard, Atomax.

Tlhahlobo

Litlhahlobo tse ngata tsa lithethefatsi, tse arolelanoang ke lingaka le bakuli li ntle. Batho ba ileng ba nka Atorvastatin Teva ba hlokometse mamello ea eona, phello e potlakileng, e khetholloang ke nako, le ntlafatso maemong a akaretsang. Lingaka tse hlokometseng bakuli ba ntseng ba phekoloa le Atorvastatin Teva, ba bua ka phello e ntle ea kliniki, e netefalitsoeng ke litholoana tsa mekhoa e fapaneng ea lipatlisiso.

Atorvastatin Teva ke setlhare se fokotsang lipid se etselitsoeng ho fetisa metabolism ea 'mele oa motho ka tsela eo, ka tsela eo e e sirelletsang litlamong tse mpe tsa k'holeseterole likepeng tsa litho tsa bohlokoa. Leha ho le joalo, bakuli ba lokela ho hopola hore Atorvastatin Teva ha e le hantle ke moriana, kamohelo ea bona e lokelang ho lumellanoa le ngaka ka mor'a ho hlahlojoa ka botlalo!

Foromo ea litekanyetso

Matlapa a koahetsoeng, 10 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg

Letlapa le leng le na le

ntho e sebetsang - atorvastatin calcium calcium "hydrate"

excipients: microcrystalline cellulose (GR M102), anhydrous sodium carbonate, maltose, croscarmellose sodium, magnesium stearate,

sebopeho sa koae ea filimi: hypromellose (Pharmacoat Gr.606), hydroxypropyl cellulose, triethyl citrate, polysorbate 80, titanium dioxide (E 171).

Matlapa a kopantsoe le khetla ho tloha ho tšoeu ho isa ho tšoeu, oval, e nang le biconvex holimo (bakeng sa litekanyetso tsa 10 mg, 20 mg, 40 mg, 80 mg).

Matlapa a kopantsoe le khetla ho tloha ho tšoeu ho isa ho o mosoeu, oval, e nang le biconvex holimo le "30" lehlakoreng le le leng (bakeng sa litekanyetso tsa 30 mg).

Matlapa a kopantsoe le khetla ho tloha ho tšoeu ho isa ho o mosoeu, oval, e nang le biconvex holimo le letšoao "60" ka lehlakoreng le le leng (bakeng sa litekanyetso tsa 60 mg).

Melemo ea pharmacological

Kamora ho tsamaisoa ka molomo, atorvastatin e kenella ka potlako. Ts'oarello e kholo e fihlella ka mor'a lihora tse 1-2. Ka lebaka la ho hlakisoa ha kemiso kahara mucous membrane ea mucous ea "gastrointestinal" le "sephetho sa" sa pele "ka sebete", bioavailability ea atorvastatin ke 12%, 'me bioavailability ea systemic ke 30%. Boholo bo boholo ba kabo ea atorvastatin e ka ba lilithara tse 381. Ho kopanya liprotheine tsa plasma - 98%. Atorvastatin e thehiloe ka matla ke cytochrome P450 ka ho theha li-dertho tsa ortho- le para-hydroxylated le lihlahisoa tse fapaneng tsa beta oxidation. Ts'ebetso ea inhibitory khahlano le HMG-CoA reductase ho plasma e batla e le 70% ka lebaka la metabolites e sebetsang. Atorvastatin le metabolites ea eona li qhekelloa haholo ka bile kamora metabolism ea hepatic le extrahepatic. Bophelo ba halofo ea atorvastatin ke lihora tse 14. halofo ea bophelo ba ts'ebetso ea inhibitory ea HMG-CoA reductase ke lihora tse 20-30 ka lebaka la metabolites e sebetsang.

Ho bakuli ba tsofetseng, khatello ea atorvastatin ho plasma e phahame haholo.

Maemong a ho se sebetse hantle ha matla a sebete, ho potoloha ha atorvastatin le metabolites ea eona ho eketseha ka makhetlo a 16.

Mochine oa ts'ebetso o amahanngoa le tlolo ea motsoako oa k'holeseterole ka sethaleng sa mevalonic acid ka lebaka la phokotso ea khetho ea HMG-CoA e khethiloeng. Atorvastatin e fokotsa cholesterol ea plasma le lipoprotein ka lebaka la ho senyeha ha k'holeseterole ka har'a sebete le keketseho ea palo le ts'ebetso ea hepatic low density lipoprotein receptors (LDL) holim'a cell cell, e lebisang ho ho eketseha ho eketsehileng le ho ba matla ha LDL. Atorvastatin e sebetsa hantle ho fokotseng maemo a LDL ho bakuli ba nang le homozygous hereditary hypercholesterolemia bao hangata ba sa arabele kalafo e fokotsang lipid. Ho fokotseha ha maemo a LDL ho fokotsa menyetla ea ho tšoaroa ke lefu la pelo le pelo.

Tekanyetso le tsamaiso

Pele o qala kalafo, o lokela ho leka ho fihlela taolo ea hypercholesterolemia ka ho ja, ho ikoetlisa le ho theola boima ba 'mele ho bakuli ba nang le botenya, hammoho le kalafo ea lefu lena le tlase.Ha a fana ka litlhare, mokuli o lokela ho buella phepo e tloaelehileng ea hypocholesterolemic, eo a lokelang ho e latela nakong ea kalafo.

Setlhare sena se nooa ka nako efe kapa efe ea letsatsi, ho sa tsotelehe takatso ea lijo. Tekanyetso ea lithethefatsi e khethoa ho tloha ho 10 ho isa ho 80 mg hang ka letsatsi, ho nahanela litaba tsa pele tsa LDL-C, sepheo sa kalafo le phello ea motho ka mong. Qalong ea kalafo le / kapa nakong ea keketseho ea tekanyetso ea moriana, ho hlokahala hore ho be le leihlo la dikahare tsa plasma lipid kamora libeke tse ling le tse ling le tse ling tse 2 le ho lokisa lethal dose haeba ho hlokahala.

Hypercholesterolemia ea mantlha le hyperlipidemia e tsoakiloeng (e kopaneng): ho bakuli ba bangata - 10 mg hang ka letsatsi, phello ea kalafo e iponahatsa ka nako ea libeke tse 2 mme hangata e fihla ho fihla ka nako ea libeke tse 4, ka kalafo ea nako e telele, matla a phehella.

Homozygous Familia hypercholesterolemia: 80 mg hang ka letsatsi (maemong a mangata, kalafo e lebisitse ho fokotseha ha litaba tsa LDL-C ka 18-45%).

Dyslipidemia e matla: Motsoako oa ho qala o khothalelitsoeng ke 10 mg hang ka letsatsi. Tekanyetso e ka eketsoa ho 80 mg ka letsatsi ho latela karabelo ea bongaka le mamello. Litekanyetso li lokela ho khethoa ka bonngoe ho nahanisisa ka morero o khothalletsoang oa kalafo.

Sebelisa ho bakuli ba nang le mafu a sebete: Bona. "Contraindication."

Tekanyetso ho bakuli ba nang le ho se sebetse hantle ke lefu la liphio: lefu la liphio ha le ame khatello ea bongata ba Atorvastatin-Teva ho plasma kapa tekanyo ea ho fokotseha ha litaba tsa LDL-C, ka hona, tokiso ea litekanyetso ea lithethefatsi ha e hlokehe.

Ts'ebeliso ho batho ba tsofetseng: ha ho na phapang ea polokeho, katleho, kapa ho fihlella lipheo tsa kalafo e fokotsang lipid ho batho ba baholo ha e bapisoa le bongata ka kakaretso.

Atorvastatin-Teva - sesebelisoa sa mehleng ena sa ho theola cholesterol

Atorvastatin-Teva ke setlhare se thusang bakuli ba nang le cholesterol e phahameng ba nang le li-depositi tsa polasetiki likepeng tsa bona. Litlhahlobo tsa lingaka li re ena ke moloko o mocha oa meriana, o nkiloeng ka maiketsetso.

U ka sebelisa moriana oa cholesterol oa Atorvastatin-Teva?

Setlhare ke sa sehlopha sa li-statins, empa se bonts'a katleho e phahameng ho feta meriana e tšoanang.

Karolo ea Atorvastatin-Teva ke moeli oa bohlokoa ho tsamaiso ea kopanelo le lithethefatsi tse ling.

Litaelo tsa ho sebelisa lithethefatsi bakeng sa cholesterol li na le leseli mabapi le matšoao le likarolo tsa ketso. Ntho e laetsoe ka mokhoa oa matlapa, ha k'holeseterole e qala ho sokela bophelo ba mokuli, e baka tšibollo ea mafu a mangata. Matlapa a Atorvastatin a beoa ha ho na le matšoao a joalo bakeng sa ts'ebeliso:

• mafu a pelo le methapo e ka hlahisoang ke lefutso le bophelo bo amanang le lilemo, mokhoa o fosahetseng oa tšebeliso ea joala, tšebeliso ea joala le ho tsuba,
• khatello e phahameng ea mali
• myocardial infarction le stroke,
• ho kena sepetlele hape ho bakoang ke angina pectoris,
• hypercholesterolemia ea mantlha le ea lefutso,
• tlhokeho ea ho tlatsetsa phepo e khethehileng ea phepo e fuoeng hyperlipidemia, dysbetalinoproteinemia, hypertriglyceridemia.

Cholesterol ho mafu a joalo e tšosa motho, e eketsa kotsi ea ho shoa ka tšohanyetso ho tloha likhatellong. Mochini oa ts'ebetso oa lithethefatsi o ikemiselitse ho thibela ntho e kang HMG-CoA reductase, ho fetola karolo ea eona ea mantlha 3-hydroxy-3-methylglutarin-CoA hore e be mevalonic acid. Ka lebaka leo, lipoprotein tse fokolang tsa methapo li qala ho theha, tse thusang ho fokotsa kotsi ea ho ba le mafu a pelo, atherosranceosis, le ho fokotsa palo ea li-cholesterol amana le marako a methapo ea mali.

Litlamorao

Khafetsa (> 1/100 ho isa ˂1 / 10)

- bohloko bo bakoang ke larynx le pharynx, nosebleeds

- bokhabane, dyspepsia, ho nyekeloa, lets'ollo, ho sokela

- myalgia, arthralgia, bohloko ba maoto le matsoho, mesifa ea mesifa, manonyeletso a ho ruruha, bohloko ba morao

- phetoho ea matšoao a ts'ebetso ea sebete, keketseho ea boemo ba "ineine "phosphokinase (CPK) maling (boemo ba keketseho ea" ""ineine" phosphokinase "ho feta makhetlo a 3 ho feta tekanyetso e kaholimo ho tloaelehileng 0.4% ea bakuli)

Ka linako tse ling (> 1/1000 ho ˂1 / 100)

- litoro tsa bosiu, ho hloka boroko

- kizunguzungu, paresthesia, hypesthesia, dysgeusia

- ho hlatsa, bohloko ba ka mpeng, ho luma

- bohloko ba molala, bofokoli ba mesifa

- urticaria, lekhopho la letlalo, ho hlohlona, ​​alopecia

- malaise, asthenia, bohloko ba sefuba, edema e poteletseng, mokhathala, feberu

- phello e ntle ea ho ba teng ha lisele tse tšoeu tsa mali ka har'a moroto

- maemo a eketsehang a transaminase. Liphetoho tse nyane, lia feta ebile ha li hloke tšitiso ea kalafo. Bohlokoa ba kliniki (makhetlo a 3 a phahameng ho feta tekanyo e kaholimo ea e tloaelehileng) keketseho ea li-transumase tsa serum e ile ea bonoa ho 0.8% ea bakuli ba fumanang atorvastatin. Keketseho e ne e its'epahalla ka bongata ebile e fetoha phetoho ho bakuli bohle.

Nako le nako (> 1/10000 ho ˂1 / 1000)

- Edema ea Quincke, dermatitis e matla ea likhofu, lefu la Stevens-Johnson, chefo e ka fokotsang ea lefu lena, erythema multiforme

- myopathy, myositis, rhabdomyolysis, tendinopathy, ropo ea tendon

- keketseho ea boima ba 'mele

Tse fumanehang haholo (> 1/10000 ho ˂1 / 1000)

- ho lebala, tahlehelo ea memori, amnesia, pherekano

Karabelo e latelang e bohloko e tlalehiloe, khafetsa ea eona ha e e-so theoe

- lefu la matšoafo a mahareng (ka kalafo ea nako e telele)

- lefu la tsoekere, khafetsa ho ipapisitse le ho ba teng kapa ho se be teng hoa lintho tse ka bang kotsi (ho itima lijo ha tsoekere ea mali> 5.6 mmol / l, BMI> 30 kg / m2, triglycerides e phahameng, nalane ea khatello ea mali)

- Immuno-Mediated necrotizing myopathy

Ho sebelisana le lithethefatsi

Matla a lithethefatsi ho atorvastatin

Atorvastatin e tšelisitsoe ka ho nka karolo ha cytochrome P450 3A4 (CYP3A4) mme ke karoloana ea tsamaiso ea liprotheine, ka mohlala, transporter ea hepatic ea ho koala. Ts'ebeliso e tšoanang ea lithethefatsi tseo e leng li-inhibitors tsa CYP3A4 kapa liprotheine tsa lipalangoang e ka eketsa ho tsepamisa mohopolo oa plasma ea atorvastatin le ho eketsa kotsi ea myopathy. Kotsi e kanna ea eketseha ka tšebeliso e tšoanang ea atorvastatin e nang le lithethefatsi tse ling tse ka susumetsang myopathy, ka mohlala, li-derivatives tsa fibroic acid le ezetimibe.

Li-inhibitors tse matla tsa CYP 3A4 li tsejoa ho lebisa keketseho e kholo ea mahloriso a atorvastatin. Neng kapa neng ha ho khonahala, tšebeliso e le 'ngoe le li-inhibitors tsa potoloho ea CYP 3A4 (mohlala, cyclosporine, telithromycin ,cacithromycin, delavirdine, styripentol, ketoconazole, voriconazole, itraconazole, posaconazole le bonyane li-protease inhibitors, ho kenyeletsoa le ritonavir. le ba bang). Haeba ho sa khonehe ho qoba tšebeliso e tšoanang ea lithethefatsi tsena ka atorvastatin, o lokela ho nahana ka ho nka atorvastatin ka tekanyo e tlase e ka khonehang, 'me ho boetse ho khothalletsoa tlhahlobo e nepahetseng ea kliniki ea boemo ba mokuli.

Li-inhibitors tse itekanetseng tsa CYP 3A4 (jk., Erythromycin, diltiazem, verapamil le fluconazole) li ka eketsa likhahla tsa plasma tsa atorvastatin. Ho sebelisoa ka nako e le 'ngoe ea erythromycin le li-statins ho tsamaisana le kotsi e eketsehileng ea myopathy. Lithuto tsa ts'ebelisano ea lithethefatsi ho lekola litlamorao tsa amiodarone kapa verapamil ho atorvastatin ha li e-so etsoe. Hoa tsebahala hore amiodarone le verapamil li thibela ts'ebetso ea CYP 3A4, ka hona, tsamaiso e ts'oanang ea lithethefatsi tsena tse nang le atorvastatin e ka lebisa ho litlamorao tsa atorvastatin. Kahoo, ka tšebeliso e tšoanang ea atorvastatin le li-inhibitors tsa CYP 3A4 tse leka-lekaneng, monyetla oa litekanyetso tse tlase haholo tsa atorvastatin le ona o lokela ho nahanoa. Kamora ho qala kalafo ka inhibitor kapa kamora ho fetola tekanyetso ea eona, ho khothalletsoa tlhahlobo e nepahetseng ea kliniki.

Jusi ea morara e na le karolo e le 'ngoe kapa ho feta e thibelang cytochrome CYP 3A4 mme e ka eketsa likhakanyo tsa plasma tsa atorvstatin, haholoholo ka ts'ebeliso e feteletseng ea lero la grapefruit (> lilitha tsa 1,2 ka letsatsi).

Inductors CYP 3A4

Tsamaiso e ts'oanang ea atorvastatin e nang le li-inducers tsa cytochrome P450 3A4 (mohlala, ka efavirenz, rifampicin, St. wort) e ka kenya letsoho phokotsong e sa tsitsang ea likhakanyo tsa plasma tsa atorvastatin. Ka lebaka la ts'ebetso e sebelisoang habeli ea rifampicin (ho hlohlelletsa cytochrome P450 3A le thibelo ea phepelo ea hepatic OATP1B1), ho khothaletsoa tsamaiso e tšoanang ea atorvastatin le rifampicin, hobane ts'ebetso ea atorvastatin ka nako e telele kamora ts'ebeliso ea rifampicin ea bohlokoa ea plasastrates ea diphampracinoras tse ling tse bohlokoa haholo. Leha ho le joalo, phello ea rifampicin ho ts'oaroa ha atorvastatin liseleng tsa sebete ha e tsejoe, 'me haeba ho sa khonehe ho qoba tšebeliso e ts'oanang, ts'ebetso ea mokuli e lokela ho lekoloa ka hloko.

Protein Inhibitors

Li-inhibitors tsa liprotheine tsa lipalangwang (mohlala, cyclosporine) li khona ho ntlafatsa litlamorao tsa systemic tsa atorvastatin. Hore na khatello ea khatello ea khatello ea methapo ea methapo ea mali e baka eng ha motho a le mothating oa ho otla ka lisele tsa sebete ha e tsejoe. Haeba ho sa khonehe ho qoba taolo e tšoanang ea meriana ena, ho khothalletsoa phokotso ea litekanyetso le tlhahlobo ea bongaka ea ts'ebetso.

Gemfibrozil / Fibre Acid Derivatives / Ezetimibe

Ts'ebeliso ea li-fibrate le ezetimibe joalo ka monotherapy e amana le nts'etsopele ea liketsahalo tse tsoang moahong oa mesifa, ho kenyelletsa rhabdomyolysis. Ka tšebeliso e tšoanang ea ezetimibe kapa lintho tse tsoang ho fibric acid e nang le atorvastatin, monyetla oa ho ba le liketsahalo tsena o ka eketseha. Haeba ho sa khonehe ho qoba taolo e tšoanang ea meriana ena, ho hlokahala hore u sebelise tekanyetso e fokolang ea atorvastatin ho fihlela sepheo sa kalafo, le tlhaiso e nepahetseng ea bakuli.

Khokahano ea atorvastatin le metabolites ea eona e sebetsang ka plasma ea mali e ne e le tlase (hoo e ka bang 25%) ha e ntse e nka atorvastatin ka colestipol. Ka nako e ts'oanang, phello ea lipidemic ea motsoako oa lithethefatsi actorvastatin le colestipol e feta phello e fanang ka e 'ngoe ea lithethefatsi tsena ka thoko.

Lithuto tsa tšebelisano ea atorvastatin le fusidic acid ha li e-so etsoe. Ho bile le litlaleho tsa liphetoho tse bohloko tse tsoang mesifa, ho kenyelletsa le rhabdomyolysis, ha u ntse u nka atorvastatin le fusidic acid. Mokhoa oa tšebelisano ena ha o tsejoe. Atorvastatin ha ea lokela ho fanoa ka fusidic acid. Haeba ho hlokahala ho sebelisa systemic fusidic acid, kalafo e nang le li-statins e lokela ho khaotsa nako eohle ea kalafo ka fusidic acid. Bakuli ba eletsoa hore ba ee ngakeng hang-hang haeba ba e-na le matšoao a bofokoli ba mesifa, bohloko, kapa bohloko.

Phekolo ea Statin e ka qala hape ka mor'a matsatsi a supileng ka mor'a ho fumana tekanyetso ea ho qetela ea fusidic acid. Maemong a ikhethang, ha tsamaiso ea nako e telele ea fusidic acid e hlokahala, mohlala, bakeng sa kalafo ea ts'oaetso e matla, tlhokeho ea tsamaiso e kopaneng ea atorvastatin le fusidic acid e lokela ho nkuoa ka bonngoe mme kalafo e lokela ho etsoa ka tlasa tlhokomelo ea bongaka e haufi.

Leha ho se lithuto tse entsoeng tse mabapi le tšebelisano ea atorvastatin le colchicine, linyeoe tsa myopathy li tlalehiloe ka tšebeliso ea atorvastatin le colchicine, mme atorvastatin e nang le colchicine e lokela ho sebelisoa ka hloko.

Matla a atorvastatin ho lithethefatsi tse sebelisoang ka nako e tšoanang

Ka ts'ebeliso e le 'ngoe ea 10 mg ea digoxin le atorvastatin ka tekanyetso e mengata, likhakanyo tsa tekano ea digoxin li eketseha hanyane. Bakuli ba nkang digoxin ba hloka ho hlahlojoa ka nepo.

Tšebeliso e tšoanang ea atorvastatin e nang le lithibela-pelehi tsa molomo e thusa ho eketsa likhahla tsa norethindrone le ethinyl estradiol.

Tšusumetso ena e lokela ho nahanoa ha u khetha lithibela-pelehi tsa molomo ho mosali ea noang atorvastatin.

Le ha ho tlalehiloe maemo a sa tloaelehang haholo a ts'ebelisano ea bohlokoahali le li-anticoagulants, ho bakuli ba nkang li-anticoagulants, nako ea prothrombin e lokela ho khethoa pele e qala kalafo ka atorvastatin mme hangata e lekana mehatong ea pele ea kalafo ho etsa bonnete ba hore ha ho na liphetoho tse kholo tsa nako ea prothrombin. Hang ha nako e tsitsitseng ea prothrombin e se e tlalehiloe, e ka hlahlojoa hangata hangata e khothalletsoang bakuli ba fumanang li-anticoagulants tsa coumarin. Ts'ebetso e ts'oanang e lokela ho phetoa ha u fetola tekanyetso ea atorvastatin kapa ho hlakoloa ha eona. Phekolo ea Atorvastatin e ne e sa tsamaee le maemo a ho tsoa mali kapa liphetoho tsa nako ea prothrombin ho bakuli ba sa nkeng li-anticoagulants.

Li-antacids tse nang le magnesium kapa aluminium hydroxide

Ka tšebeliso e tšoanang ea li-antacids tse nang le magnesium kapa aluminium hydroxide e nang le atorvastatin, mahloriso a ho qetela ka plasma ea mali a fokotseha.

Litaelo tse khethehileng

Ketso ea mesifa ea masapo

Atorvastatin, joalo ka li-inhibitors tse ling tsa HMG-CoA reductase (hydroxymethylglutaryl coenzyme A reductase), ka linako tse ling e ka ama mesifa ea masapo mme ea baka myalgia, myositis, le myopathy, e ka tsoelang pele ho rhabdomyolysis, boemo bo behang bophelo bo ts'oanang le maemo a phahameng haholo a tlhahiso ea kinine. (QC) (> makhetlo a 10 VPN), myoglobinemia le myoglobinuria, e ka lebisang ho se sebetseng hantle ha methapo. Nalane ea mokuli ea ho senyeheloa ke a liphio le eona e ka ba sesosa sa kotsi bakeng sa rhabdomyolysis. Ka tšebeliso e kopaneng ea atorvastatin e nang le lithethefatsi tse ngata, tse kang cyclosporine le li-inhibitors tse matla tsa CYP 3A4 (clearithromycin, intraconazole, HIV protease inhibitors), kotsi ea ho ba le myopathy / rhabdomyolysis e eketseha.

Ho Abela Atorvastatin-Teva e lipid-theola tekanyetso hammoho le derivatives fibric acid e, erythromycin, cyclosporin, Teli-tromitsinom, immunosuppressants, tlhakantsuke ya HIV protease inhibitors (saquinavir, ritonavir, lopinavir le ritonavir, tipranavir, ritonavir, darunavir le ritonavir, fosamprenavir le ritonavir) , niacin, meriana ea aerosol antifungal kapa nicotinic acid, hammoho le colchicine, ngaka e lokela ho sekaseka ka hloko melemo le likotsi tsa kalafo ena 'me li hlokomele bohloko kamehla 's ho lemoha bohloko kapa bofokoli ka mesifa, haholo-holo nakong ea likhoeli tse' maloa pele ba kalafo le linakong tsa ho eketseha ha tekanyetso ea paakanyong efe kapa efe mabapi le kotsi ea ho myopathy. Ha li kopantsoe le lithethefatsi tse kaholimo, monyetla oa ho sebelisa litekanyetso tsa pele le tlhokomelo ea atorvastatin e lokela ho nahanoa. Maemong a joalo, boikemisetso ba nako le nako ba ts'ebetso ea CPK bo ka khothaletsoa, ​​leha ho ba leihlo joalo ho sa thibele nts'etsopele ea myopathy e matla.

Litlhahiso tsa ho khethoa ha lintho tse kopaneng li akaretsoa ka bokhutšoanyane tafoleng e ka tlase.

Ho sebelisana le lithethefatsi tse amanang le lithethefatsi tse amanang le kotsi e eketsehileng ea myopathy / rhabdomyolysis

Morero

Cyclosporin, HIV protease inhibitors (tipranavir e nang le ritonavir), hepatitis C vaerase protease inhibitor (telaprevir), fusidic acid

Qoba ho sebelisa atorvastatin

HIV protease inhibitor (lopinavir e nang le ritonavir)

Sebelisa ka hloko le ka tekanyo e tlase e hlokahalang.

Clarithromycin, intraconazole, protease inhibitors tsa (saquinavir tse nang le ritonavir *, darunavir e nang le ritonavir, fosamprenavir, fosamprenavir ka ritonavir)

Se ke oa feta tekanyetso ea atorvastatin

HIV proteinase inhibitor (nelfinavir), lefu la vaerase ea hepatitis C inhibitor (boceprevir)

Se ke oa feta tekanyetso ea atorvastatin 40 mg ka letsatsi

* Sebelisa ka hloko le ka tekanyo e tlase e hlokahalang.

Atorvastatin-Teva e laetsoa ka tlhokomeliso ho bakuli ba nang le mabaka a rerang ho rhabdomyolysis ka nts'etsopele ea ho hloleha ka boiqapelo ka lebaka la myoglobinuria le myoglobinemia (hypothyroidism, lefutso la ho fufuleloa ha lefu la setho sa botona, ho se sebetse hantle ke nalane ea lefu la sebete, ts'ebeliso ea bongata ba joala bo tahang nalane ea li-statins kapa li-fibrate, mokuli o lilemo tse fetang 70). Tabeng ena, ho hlokahala ho ithuta boemo ba mofuta oa creatine phosphokinase (KFK), mme haeba boemo ba KFK bo feta makhetlo a 5, kalafo ha ea lokela ho qala. Nakong ea kalafo, haeba ho na le litletlebo tsa bohloko ba mesifa, makhopho, bofokoli, malaise, le feberu, hoa hlokahala ho khetholla boemo ba CPK, 'me haeba CPK e feta makhetlo a 5, ka nakoana kapa ho emisa ka botlalo kalafo le atorvastatin.

Bakuli ba fuoeng Atorvastatin-Teva ba lokela ho lemosoa hore ba lokela ho ea ngakeng hang-hang haeba ho e-ba le bohloko bo sa hlalosoang kapa bofokoli ba mesifa, haholoholo haeba bo tsamaisana le malaise kapa feberu.

Ketso ho sebete

Kamora kalafo le atorvastatin, keketseho e kholo (e fetang makhetlo a 3 ha e bapisoa le moeli o kaholimo o tloaelehileng) keketseho ea mosebetsi oa serum ea "transaminase" ea "sebete" e hlokometsoe.

Hoa hlokahala ho lekola matšoao a ts'ebetso ea sebete nakong eohle ea kalafo, haholo-holo ka ponahalo ea matšoao a kalafo ea tšenyo ea sebete. Tabeng ea keketseho ea litaba tsa transpase tsa hepatic, tšebetso ea bona e lokela ho beoa leihlo ho fihlela meeli ea se tloaelehileng e fihlelle. Haeba keketseho ea ts'ebetso ea AST kapa ALT ka makhetlo a fetang a 3 ha e bapisoa le moeli o kaholimo oa tloaelo e bolokiloe, ho khothalletsoa hore tekanyo e fokotsoe kapa e hlakoloe.

Bakuli ba nkang Atorvastatin-Teva ba lokela ho hana ho noa joala. Sebelisa ka hloko ho bakuli ba sebelisang joala hampe le / kapa ba nang le lefu la sebete (nalane).

Thibelo ea Stroke Ho Fokotsa Aggressive Cholesterol Reduction (SPARCL) / Hemorrhagic Stroke

Bakeng sa bakuli ba nang le nalane ea hemorrhagic stroke kapa lacunar infarction, tekanyo ea tekanyo / phaello ea melemo ea atorvastatin ka lethal dose ea 80 mg ha e khethoe, ka hona, ts'ebeliso ea Atorvastatin-Teva ho bakuli ba joalo e ka etsahala feela kamora ho tseba tekanyo ea kotsi / molemo. Nahana ka kotsi e ka bang teng ea ho khahlapeha ha hemorrhagic stroke.

Immuno-Mediated Necrotic Myopathy (IONM)

Maemong a sa tloaelehang haholo, nakong ea kalafo kapa ka mor'a eona e nang le mofuta o itseng oa li-statins, ho thoe ho na le immuno-mediated necrotic myopathy (IONM). IONM e tšoauoa ka bongaka ke bofokoli bo sa feleng ba mesifa le ho eketseha ha maemo a serum creatine kinase, e phehellang esita le ka mor'a hore kalafo e nang le li-statins e khaoe. Maemong ha kalafo e nang le atorvastatin e hloka kalafo e ts'oanang le meriana ena, ho bohlokoa ho ithuta ka hloko tekanyo ea melemo / melemo ea kalafo e kopaneng.

Lefu la setho sa matšoafo

Maemo a ikhethang a lefu la "interstitial pulmonary" a tlalehiloe le li-statins tse itseng, haholo-holo nakong ea kalafo ea nako e telele. Haeba nakong ea kalafo ho na le matšoao a nts'etsopele ea lefu lena la "interstitial pulmonary" (ho hema hanyane, ho khohlela ho sa beheng, mokhathala, ho fokotsa boima ba 'mele, feberu), kalafo ea "statin" e lokela ho emisoa.

Statins e eketsa tsoekere ea mali, mme ho bakuli ba bang ba nang le kotsi e kholo ea ho ba le lefu la tsoekere nakong e tlang, ba ka lebisa ho hyperglycemia, moo ho leng bohlale ho qala kalafo ea lefu la tsoekere. Leha ho le joalo, kotsi ena e fetisoa ke melemo ea ho fokotsa kotsi ho methapo ea mali ka li-statin, ka hona ha ea lokela ho ba lebaka la ho emisa kalafo ea statin. Bakuli ba kotsing ea ho kula (glucose e potlakileng ea 5.6-6.9 mmol / L, BMI> 30 kg / m2, li-triglycerides tse phahameng, khatello ea mali) li-statins li lokela ho ba tlasa tlhahlobo ea bongaka le ea biochemical.

Ts'ebeliso e tšoanang ea atorvastatin le fusidic acid ha e khothalletsoe, ka hona, ho hlokahala hore u nahane ka monyetla oa ho khaotsa ha nakoana ka atorvastatin nakong ea kalafo ka fusidic acid.

Re lokela ho hopola hore ha ho nkuoa Atorvastatin-Teva ka lero la morara, ho kopana ha atorvastatin ka har'a plasma hoa eketseha le ho ba le menyetla ea litla-morao.

Ts'ebeliso ea bongaka

Ho bana ba ka tlase ho lilemo tse 18, ts'ebetso le polokeho ha li so theoe ka lebaka la boiphihlelo bo fokolang ba ts'ebeliso.

Lintlha tsa phello ea lithethefatsi ho bokhoni ba ho khanna koloi kapa mekhoa e ka bang kotsi

Ka lebaka la litla-morao tsa moriana, tlhokomeliso e lokela ho sebelisoa ha u khanna koloi le mekhoa e meng e ka bang kotsi.

Fomu ea ho lokolla le ho paka

Matlapa a 10 ka har'a pakete ea blump Alu / Alu, e nang le filimi ea polyvinyl chloride kapa polyvinylidene chloride le foil ea varnished aluminium le filimi ea polyvinyl chloride polyamide le foil ea aluminium.

Lipakete tse 3 tsa lisele tsa contour hammoho le litaelo tsa tšebeliso ea bongaka maemong a 'muso le lipuo tsa Serussia li kenngoa ka karete ea karete.

Moriana oa Atorvastatin-Teva: litaelo, li-contraindication, analogues

Atorvastatin-Teva ke sethethefatsi sa hypolipidemic. Mokhoa oa ts'ebetso oa lithethefatsi tse fokotsang lipid ke ho fokotsa sekhahla sa "cholesterol" e mpe, hammoho le palo ea li-triglycerides le lipoprotein tsa methapo e tlase haholo le e tlase haholo. Ka lehlakoreng le leng, ba eketsa bongata ba lipoprotein tse phahameng le "cholesterol" e ntle.

Atorvastatin-Teva e fumaneha ka mofuta oa matlapa a bosoeu ba filimi. Ho ngotsoe mongolo o habeli lintlheng tsa bona, e 'ngoe ea tsona ke "93",' me ea bobeli e latela litekanyetso tsa moriana. Haeba litla-morao ke 10 mg, ho ngotsoe "7310" haeba 20 mg, ebe "7311", haeba 30 mg, ebe "7312", kapa 40 mg, ebe "7313".

Motsoako o ka sehloohong oa Atorvastatin-Teva ke calcium atorvastatin. Hape, sebopeho sa moriana se kenyelletsa lintho tse ling tse ngata tse thusang. Tsena li kenyelletsa, ka mohlala, lactose monohydrate, titanium dioxide, polysorbate, povidone, alpha-tocopherol.

Mochine oa ts'ebetso oa Atorvastatin-Teva

Atorvastatin-Teva, joalo ka ha ho se ho boletsoe qalong, ke moemeli ea fokotsang lipid. Matla ohle a hae a ikemiselitse ho thibela, ke hore, ho thibela ketso ea enzyme tlasa lebitso la HMG-CoA reductase.

Karolo e ka sehloohong ea enzyme ena ke ho laola ho etsoa ha k'holeseterole, kaha ho thehiloe moetapele oa eona, mevalonate, ho tloha ho 3-hydroxy-3-methyl-glutaryl-coenzyme A. Ho qala ho hlaha k'holeseterole e kopantsoeng, hammoho le triglycerides, moo e kopanang le lipoprotein tse fokolang haholo. . Khemikhale e thehiloeng e fetela kahara lero la mali, ebe ka mor'a moo e isoa litho le liseleng tse ling.

Li-lipoprotein tse tlase haholo li fetoleloa ho lipenshene tse tlase haholo ka ho ikopanya le li-receptor tsa tsona tse ikhethang. Ka lebaka la ts'ebelisano ena, bo-catabolism ba bona, ke., Ho bola, hoa etsahala.

Setlhare se fokotsa bongata ba k'holeseterole le lipoprotein maling a bakuli, se thibela phello ea enzyme le ho eketsa palo ea li-receptor ka har'a sebete bakeng sa lipoprotein tse tlase. Sena se etsa hore ba li hapelle le ho li lahla. Ts'ebetso ea synthesis ea lipoprotein ea atherogenic le eona e fokotsehile haholo. Ntle le moo, khoholeho ea cholesterol e phahameng ea methapo e eketseha mme li-triglycerides lia fokotseha hammoho le apolipoprotein B (protheine ea 'mele).

Ts'ebeliso ea Atorvstatin-Teva e bonts'a liphetho tse phahameng kalafong ea lefu la atherosclerosis feela, empa le maloetse a mang a amanang le metabolism ea lipid, eo ho eona lipilisi tse ling tse fokotsang lipid li neng li sa sebetse.

Ho fumanoe hore menyetla ea ho ba le mafu a amanang le pelo le methapo ea mali, e kang ho nyekeloa ke pelo le stroke, e fokotsehile haholo.

Pharmacokinetics of Atorvastatin-Teva

Setlhare sena se kenella ka potlako. Ka lihora tse ka bang peli, motsoako o phahameng ka ho fetisisa oa lithethefatsi o tlalehiloe maling a mokuli. Ho kenyelletsa, ke hore, ho monya, ho ka fetola lebelo la eona.

Mohlala, e ka fokotsa butle ha o ntse o nka litafole ka lijo. Empa haeba ho amoheloa ka tsela ena ho fokotsa lebelo, joale ha ho ame phello ea Atorvastatin ka boeona - cholesterol e ntse e tsoela pele ho fokotseha ho latela litekanyetso. Ha o kena 'meleng, sethethefatsi sena se fetoha ka mokhoa o feteletsang oa' mele ka mpeng ea gastrointestinal. E amana haholo le liprotheine tsa plasma - 98%.

Liphetoho tse ka sehloohong tsa metabolic le Atorvastatin-Teva li etsahala ka har'a sebete ka lebaka la ho pepesetsoa mahloenzymes. Ka lebaka la sena, ho thehoa li-metabolites tse sebetsang, tse ikarabellang bakeng sa ho thibela phetoho ea HMG-CoA. 70% ea litlamorao tsohle tsa moriana o etsahala hantle ka lebaka la metabolites tsena.

Atorvastatin e epolloa ho tsoa 'meleng ka hepatic bile. Nako eo ka eona khatello ea meriana e leng maling e tla lekana le halofo ea mantlha (seo ho thoeng ke halofo ea bophelo) ke lihora tse 14. Tšusumetso ea enzyme e nka hoo e ka bang letsatsi. Ha ho liperesente tse peli tsa palo e amoheloang e ka qetoang ka ho hlahloba moroto oa mokuli. Bakeng sa bakuli ba nang le bothata ba ho phekoloa ka methapo, ho lokela ho hopoloa hore nakong ea hemodialysis, Atorvastatin ha e siee 'mele.

Palo e phahameng ea lithethefatsi e feta se tloaelehileng ka 20% ho basali, mme tekanyo ea ho felisoa ha eona e fokotsehile ka 10%.

Ho bakuli ba nang le bothata ba ho senyeha ha sebete ka lebaka la tšebeliso e mpe ea joala bo sa feleng, khatello e phahameng e eketseha ka makhetlo a 16, mme sekhahla sa ho chesa se theoha ka makhetlo a 11, ho fapana le se tloaelehileng.

Matšoao le contraindication bakeng sa ts'ebeliso

Atorvastatin-Teva ke setlhare se sebelisoang haholo mokhoeng oa kajeno oa bongaka.

Ho phekola maloetse afe kapa afe a kaholimo ho etsoa ha u ntse u shebile lijo tse thusang ho fokotsa cholesterol ea mali (e phahameng merohong le meroho e metenya, litlama, monokotsoai, lijo tse tsoang leoatleng, likhoho, mahe), hammoho le ho se na litholoana tse tsoang pejana kalafo e sebelisitsoeng.

Ho na le lipontšo tse 'maloa tseo ho tsona a ipakile a sebetsa hantle:

• atherosulinosis
• hypercholesterolemia ea mantlha,
• heterozygous hypercholesterolemia ea lelapa le e seng lelapeng,
• Hypercholesterolemia (mofuta oa bobeli ho ea ka Fredrickson),
• triglycerides e phahameng (mofuta oa bone ho latela Fredrickson),
• ho se leka-lekane ha lipoprotein (mofuta oa boraro ho ea ka Fredrickson),
• homozygous Familia hypercholesterolemia.

Ho boetse ho na le likhanyetsano tse 'maloa mabapi le ts'ebeliso ea Atorvastatin-Teva:

1. Maloetse a sebete a sethaleng kapa a ntse a le maemong a eketsehileng.
2. Keketseho ea boemo ba sampuli tsa hepatic (ALT - alanine aminotransferase, AST - aspartate aminotransferase) e feta makhetlo a mararo ntle le mabaka a hlakileng.
3. Ho hloleha ha sebete.
4. Bokhachane le pelehi.
5. Bana ba banyane.
6. Lipontšo tsa lefu la ho kula ha o nka likarolo life kapa life tsa moriana.

Maemong a mang, lipilisi tsena li lokela ho fanoa ka hloko e kholo. Tsena ke linyeoe tse kang:

• tšebeliso e ngata ea lino tse tahang,
• concomitant sebete
• ho se leka-lekane ha li-hormonal,
• ho se leka-lekane ha li-electrolyte,
• mathata a metabolic
• khatello e tlase ea mali
• leqeba le tšoaetsanoang le tšoaetsanoang
• lefu la sethoathoa le sa sebetsoang
• ts'ebetso e kholo le likotsi tse mpe tse bohloko

Ntle le moo, ho ba hlokolosi ha u sebelisa moriana ho lokela ho ikoetlisa boteng ba methapo ea methapo.

Ho sebelisana le meriana e meng

Atorvastatin-Teva e ferekane le nts'etsopele ea myopathy - bofokoli bo matla ba mesifa, joalo ka lithethefatsi tsohle tsa sehlopha sa HMG-CoA reductase inhibitors. Ka tšebeliso e kopaneng ea lithethefatsi tse 'maloa, menyetla ea ho ba le lefu lena e ka eketseha haholo. Tsena ke lithethefatsi tse kang fibrate (e 'ngoe ea lihlopha tsa meriana ea anticholesterolemic), lithibela-mafu (erythromycin le macrolides), lithethefatsi tsa antifungal, livithamini (PP, kapa nicotinic acid).

Lihlopha tsena li sebetsa ho enzyme e ikhethang e bitsoang CYP3A4, e phethang karolo e kholo ho Atorvastatin-Teva metabolism. Ka mofuta ona oa phekolo ea ho kopanya, boemo ba atorvastatin maling bo ka eketseha ka lebaka la thibelo ea enzyme e boletsoeng ka holimo, kaha lithethefatsi ha li hlahisoe hantle. Lithethefatsi tsa sehlopha sa fiber, mohlala, Fenofibrate, li thibela ts'ebetso ea phetoho ea Atorvastatin-Teva, ka lebaka leo palo ea eona maling le eona e eketsehang.

Atorvastatin-Teva e kanna ea lebisa ho nts'etsopele ea rhabdomyolysis - ena ke ts'ebetso e kholo ea lefu la kelello e hlahang e le sephetho sa nako e telele ea myopathy. Ts'ebetsong ena, mesifa ea mesifa e senyeha haholo, kabo ea bona ka har'a moroto ea bonoa, e leng se ka lebisang ho hlohlonteng ha renal. Rhabdomyolysis hangata e hlaha ka ts'ebeliso ea Atorvastatin-Teva le lihlopha tse ka holimo tsa lithethefatsi.

Haeba u fana ka moriana o nooa ka tekanyetso e kholo e amoheloang ea letsatsi le letsatsi (80 mg ka letsatsi) mmoho le pelo gaccide Digoxin, joale ho na le keketseho ea khatello ea Digoxin ke hoo e ka bang karolo e le 'ngoe ho tse hlano ea lethal dose.

Ho bohlokoa haholo ho kopanya ts'ebeliso ea Atorvastatin-Teva le lithethefatsi tsa thibelo ea bokhachane tse nang le estrogen le melemo ea eona, kaha ho na le keketseho ea boemo ba lihomone tsa basali. Ho na le taba ho basali ba lilemo tsa ho ba le bana.

Bakeng sa lijo, ho khothalletsoa ka hloko ho fokotsa tšebeliso ea lero la morara, hobane e na le ntho e fetang e le 'ngoe e thibelang enzyme, tlasa ts'usumetso ea hore lits'ebetso tsa mantlha tsa metabolism tsa Atorvastatin-Teva li etsahala mme boemo ba eona maling bo eketseha. Setlhare sena se ka rekoa k'hemisteng efe kapa efe ka taelo ea ngaka.

Tlhahisoleseling ka lithethefatsi Atorvastatin e fanoa ka har'a video ena sehloohong sena.