Na Stem Cell Cure lefu la tsoekere?

Maemong a mang, li-MSC tse khothalletsoang ho tsoa lithong tsa adipose ke tsona tse tsebahalang haholo:

• maemong ao ho arohanoang ha lisele tsa hematopoietic stem ho sa khoneheng kapa ho sa rateheng (mafu a mang, lilemo, karohano e ngata e neng e etsoa pele),
• ho mafu a itseng (vascular, tsoekere mellitus), ha thepa ea cellular ka boeona e kenya letsoho ts'ebetsong ea kalafo

Lisele tsa Adipose Stem

Adipose tiske ke lisebelisoa tsa tlhaho tsa tlhaho tse fumanehang habonolo ha li bapisoa le moko oa masapo, mohloli o ka sehloohong oa li-MSC. Li-MSC tse fumanoeng ho lithaelese tsa adipose li loketse haholoanyane bakeng sa tšebeliso ea li-traumatology le orthopedics, kaha li khetholla ka mokhoa o sebetsang hantle liseleng tsa masapo. Ntle le moo, li-MSC tsa adipose li ka phahamisa kholo ea masapo ka lebaka la secretion ea vascular endothelial grow factor (VEGF), e netefatsang katleho ea ts'ebeliso ea tsona ho mafu a kang ischemia e tlase ea maoto.

Tse khahlisang haholo immunosuppression thepa ea li-MSCs le tšebeliso e lumellanang ea li-MSC bakeng sa kalafo ea maemo a thibelo ea mafu a amanang le mafu a tšoaetsanoang, eseng fela ka matla joalo ka karabelo e kopanetsoeng le mofani oa mofuta oa 1 lefu la tsoekere, empa hape e atile joalo ka mohlala, karabelo ea mefuta-futa ea li-etiologies tse fapaneng le boima. Lisele tsa Mesenchymal stem cell (MSCs) li tsejoa li khona ho thibela tšebetso e sebetsang ea li-T-lymphocyte, B-lymphocyte, lisele tsa dendritic le lisele tsa tlhaho tse bolaeang (NK), 'me sistimi ena e sebetsa ka molao-motheo oa ho fana ka maikutlo.

Sena sohle se etsa hore MSC e be moemeli oa kalafo ea maloetse a mangata a autoimmune mme, pele ho tsohle, LITLHAKU TSE KHOLO 1 ho batho ba baholo le bana. Karolo ea bohlokoahali ea li-MSC ke ho se khone ho itšireletsa ha 'mele ho feta tekano, mme ho feta moo, bokhoni ba bona ba ho hatella karabo ea' mele ea ho itšireletsa mafung, e bohlokoa haholo ha o phetha mefuta eohle ea lipallo tsa allogeneic.

Ha e kenngoa ka har'a li-ventricle kapa ntho e tšoeu ea bokong, lisele tsa mesenchymal stem li fallela ho parenchyma ea lisele tsa methapo ebe li arola likarolo tse tsoang mokokotlong oa sele ea glial kapa neuronal. Ntle le moo, ho na le bopaki ba transdifferentiation ea MSCs liseleng tsa hematopoietic stem ka bobeli vitro le vivo. Ka tlhahlobo e tebileng haholoanyane, lithutong ka bonngoe, ho ile ha etsoa qeto ea polasetiki e phahameng haholo ea li-MSC, e iponahatsang ka bokhoni ba bona ba ho khetholla li-astrocyte, oligodendrocyte, neurons, cardiomyocyte, lisele tse boreleli tsa mesifa le lisele tsa mesifa ea masapo.

Phuputsong e 'maloa mabapi le bokhoni ba transdifferentiation ba li-MSCs ka vitro le vivo, ho fumanoe hore li-proenitors tse ngata tsa mesenchymal tsa tšimolo ea masapo a marapo li arotsoe ka mokhoa o hlakileng ho likarolo tsa cell tse etsang lesapo, lefufuru, mesifa, methapo ea methapo le adipose, hammoho le tendons le stroma e tšehetsang hematopoiesis.

TLHOKOMELISO, HO BONT THEA KHAOLO EA MAHALA A SEBELISO A SEBELISANG LITLHAKISO TSA HO FUMANA LITLHAKISO TSE KHOLO, LITLHAKISO TSA HO FIHLELA (LITLHAKISO), LITLHOHONOLO TSE BANG TSE KHOLO.

Ho tloha ka Pherekhong 2015, phekolo e nang le lisele tsa methapo ea methapo e bokellaneng ho tsoa liseleng tsa adipose ke mokhoa o theko e tlase, o sa sebelisoeng le thibelo ea lilemo (boemo feela ke boteng ba lithane tsa adipose).

Bakuli ba bang, ehlile, ba leka ho fumana khetho e theko e tlaase haholo ea ho etsa ts'ebetso eo ebe "ba hata ka leihlo le le leng." Taba ke hore theknoloji ha e eme. Ho na le phapang e kholo temong ea setso sa lisele bakeng sa likhoeli tse 'maloa Belarus kapa "hanghang" Chaena le ea sejoale-joale e nkile bohato bo netefalitsoeng Thailand le Japane. Khafetsa re eteloa ke batho ba ithaopelang ho tlisa lisele tsa bona tsa litafole ka vitro li tsoa Chaena le Hong Kong ntle le phasepoto ea sele. Ke hlalosa hore lisele tsa stem ha li lule tikolohong e tloaelehileng ka mocheso o tloaelehileng. Ho na le litekanyetso tse thata tsa temo, ho bata, ho qhekella, lipalangoang le phetisetso ho tsoa melaong ena li ka se tlohe ka kotloloho.

U hloka ho ba hlokolosi 'me u qale ka ho ba le bonnete ba hore na ke mokhatlo o ikopanyang le eng. Re bile re bonts'a bakuli ba rona skrineng ea microscope le data ea khethollo ea li-cluster hore tsena ke lisele tsa stem. Hobaneng? Ho na le litlatsetso ha Moscow, ho feta mokhatlo o tiileng o nang le laesense le tumello tse sa utloahaleng ho hang, o ile oa tsebisa bakuli ba ona eng kapa eng, empa eseng lisele tsa stem.

Ke ka lebaka leo re khethang ka hloko balekane eseng lipampiri, empa bakeng sa liphetho. Se ke oa tšaba ho botsa! Mme leha ho le joalo (ho joalo, ho loketseng naha ea rona), 'mele oa motho o shebile ka nepo ntho e' ngoe le e 'ngoe e kenyelitsoeng ho eona. Ho kenyelletsa moetlo oa mofani, eseng o fanang ka boitšoaro, ho ka khoneha mothating ona feela, haeba re batla ho fumana ts'usumetso ntle le mathata, mme ho feta moo, ha ho utloahale ho sebelisa lisele tsa stem: semela, phoofolo le ba bang. Oho, ha ke soasoa - ba na le thahasello, hobane papatso e joalo e etsahala nako le nako.

Bakeng sa ba batlang lintlha mabapi le katleho ea tšebeliso ea lisele tsa stem ka mofuta oa 1 lefu la tsoekere (hematopoietic):