Glimekomb - (Glimekomb) litaelo tsa tšebeliso

Foromo ea litekanyetso - matlapa: flat-cylindrical, ho tloha ho tšoeu ho ea ho tšoeu ka tranelate e putsoa kapa e bosehla (mmala oa marbling oa khonahala), ka notch le bevel (li-pcs tse 10. Ka lipaketeng tsa lisele tsa contour, ka lebokoseng la karete tsa 6, liphutheloana tse 20. lithutsoana, ka lebokoseng la mekotla e 5, liphutheloana tse 30, 60 le tse 120. ka libotlolong tsa polasetiki, ka lebokoseng la mekotla e 1

Lintho tse sebetsang tse thathamisitsoeng letlapeng le le leng:

• metformin hydrochloride - 500 mg,
• gliclazide - 40 mg.

Lisebelisoa tse ling: croscarmellose sodium, povidone, magnesium stearate, sorbitol.

Matšoao a ho sebelisoa

• thaepa mellitus ea 2 lefu la tsoekere ha ho sa sebetse hantle kalafo ea ho ja, ho ikoetlisa 'meleng le ho phekola monotherapy e fetileng ka gliclazide kapa metformin,
• mofuta oa 2 lefu la tsoekere le lenane la tsoekere e tsitsitseng le e laoloang hantle - ho nkela phekolo e kopaneng ea nakong e fetileng lithethefatsi tse peli (gliclazide le metformin).

Contraindication

• hypoglycemia,
• lefu la tsoekere la ketoacidosis, lefu la tsoekere le leta,
• mofuta oa 1 lefu la tsoekere
• ho hloleha ha sebete
• mafu a hlobaetsang le a sa foleng a tsamaeang le "hypoxia" ea tiske: infraction ea myocardial ea morao-rao, ho hema le ho hloleha ha pelo, ho ts'oha,
• maemo a hlobaetsang a ka lebisang phetohong ea ts'ebetso ea liphio: ts'oaetso e matla, ho felloa ke metsi, ho tsitsipana,
• Ho senyeha ha real,
• lactic acidosis, ho kenyelletsa le nalane ea
• mafu a tšoaetsanoang, ho chesoa ho hoholo, likotsi, ho kenella ka matla ha ho buuoa le maemo a mang a hlokang kalafo ea insulin,
• porphyria
• botahoa haholo, tahi e sa foleng,
• ho khomarela lijo tse nang le khalori e tlase (ka tlase ho likhalori tse 100 / ka letsatsi),
• nako ea kemaro le kanyeso,
• ho etsa tlhahlobo ea radioisotope kapa X-ray ka ho hlahisoa ha iodine e nang le phapang e mahareng (lihora tse 48 pele le lihora tse 48 kamora moo),
• Tšebeliso e tšoanang ea miconazole,
• hypersensitivity ho karolo efe kapa efe e sebetsang kapa e thusang ea lithethefatsi kapa tse ling tse tsoang ho sulfonylurea.

Glimecomb ha e khothalletsoe ho bakuli ba ka holimo ho lilemo tse 60 ba etsang mosebetsi o boima oa 'mele (ka lebaka la kotsi e kholo ea ho ba le lactic acidosis).

• lefu la qoqotho le tlola tšebetso ea lona,
• adrenal haelloang
• febrile syndrome
• hypofunction ea anterior pituitary gland.

Tekanyetso le tsamaiso

Glimecomb e lokela ho nooa ka molomo nakong ea lijo kapa hang ka mor'a lijo.

Ngaka e beha tekanyetso ka bonngoe, ho latela boemo ba tsoekere maling.

Tekanyetso ea pele ea letsatsi le letsatsi, joalo ka molao, ke matlapa a 1-3, ebe e eketsoa butle-butle, haeba ho hlokahala, ho fihlela phello e tsitsitseng ea lefu lena e ka fumaneha.

Sekhahla se phahameng sa letsatsi le letsatsi ke matlapa a 5.

Tekanyetso ea letsatsi le letsatsi hangata e aroloa ka litekanyetso tse peli - hoseng le mantsiboea.

Litlamorao

• karabelo:
• lehlakoreng la metabolism: ho ja ka mokhoa o sa lekanang le ho tlola mofuta oa dosing - hypoglycemia (tlala, hlooho e bohloko, mokhathala, bofokoli bo tebileng, ho tsekela, ho fufuleloa ka sekhahla, mathata a nakoana a methapo, ts'ebelisano e sa tsamaeang ea motsamao, palpitations, le tsoelo-pele ea hypoglycemia - tahlehelo ea boitšoaro le taolo) , maemong a mang - lactic acidosis (bohloko ba ka mpeng, mathata a ho hema, ho theola khatello ea mali, ho otsela, myalgia, bofokoli, hypothermia, Reflex bradyarrhythmia),
• Ho tsoa lithong tsa hemopoietic: ka seoelo - thibelo ea masapo a hematopoiesis (thrombocytopenia, anemia, leukopenia),
• ho tsoa ho tšilo ea lijo: ho lahleheloa ke takatso ea lijo, mathata a dyspeptic (tatso ea tšepe molomong, lets'ollo, ho nyekeloa ke pelo, ho ikutloa a le boima ho epigastrium), ka seoelo - ts'enyo ea sebete (mosebetsi o eketsehileng oa lipilisi tsa hepatic transitiase le alkaline phosphatase, cholestatic jaundice, hepatitis),
• Tse ling: ho sitisoa ha pono.

Liphetho tsa sulfonylureas, tse kenyang e 'ngoe ea metsoako e sebetsang ea Glimecomb (glyclazide), e ka baka litlamorao tse latelang: alculgic vasculitis, hemolytic anemia, agranulocytosis, pancytopenia, erythropenia, le ho fokola ha sebete.

Haeba ho na le lithethefatsi tse ngata le ho ba teng ha maemo a kotsi ka lebaka la metformin eo e leng karolo ea lithethefatsi, ho hola ha lactic acidosis hoa khoneha - boemo bo hlokang tlhokomelo ea tšohanyetso ea bongaka (matšoao a eona a hlalositsoe kaholimo). Phekolo e lokela ho etsoa sepetlele. Phekolo e sebetsang ka ho fetisisa bakeng sa khatello ena ke hemodialysis.

Hape, overdose e ka lebisa nts'etsopele ea hypoglycemia, hobane gliclazide ke karolo ea lithethefatsi. Ka bonolo le bonyane ba tekanyetso ea hypoglycemia, tsoekere (dextrose) e lokela ho fanoa kapa tharollo ea tsoekere e nkiloeng ka molomo. Ho hypoglycemia e matla (e bontšitsoeng ke ho lahleheloa ke ho tseba) tharollo ea 40% ea tsoekere (dextrose) e kenngoa ka har'a methapo ea methapo, ka mokokotlong kapa ka har'a glucagon. Kamora hore mokuli a fole, o hloka ho fuoa lijo tse nang le lik'habohaedreite ho thibela tsoelopele ea hypoglycemia.

Litaelo tse khethehileng

Glimecomb e fuoa feela bakuli ba fumanang lijo tse tloaelehileng tse nang le lik'habohaedreite tse tlase, tse kenyeletsang lijo tsa hoseng.

Nakong ea kalafo, o lokela ho lekola khafetsa boemo ba tsoekere maling maling ka mpeng e se nang letho le ka mor'a ho ja, haholo-holo matsatsing a pele a ho sebelisa moriana.

Glimecomb e lokela ho emisoa lihora tse 48 pele ho ts'ebetso e kenang ea moemeli ea nang le iodine e nang le iodineine kapa ho kenella ts'ebetsong. U ka qala ho nka lihora tse 48 pele ho moo.

Ho tlameha ho hopoloa hore li-sulfonylurea derivatives (ntlheng ena, glyclazide) li ka baka hypoglycemia, maemong a mang e le ka mokhoa o thata le oa nako e telele. Hangata, boemo bona bo hlaha ka ho ja lijo tse nang le khalori e fokolang, kamora ho ikoetlisa ka matla kapa ka nako e telele, kamora ho noa joala le ha o ntse o nka li-hypoglycemic agents. Bakeng sa ho qoba nts'etsopele ea hypoglycemia, ho hlokahala hore ka hloko le ka bomong u khethe lethal dose ho mokuli ka mong le ho mo fa tlhaiso-leseling e felletseng ka kalafo e tlang.

Motsoako oa Glimecomb o lokela ho fetoloa ha o fetola lijo, ka khatello ea maikutlo le ea 'mele.

Lihlopha tse latelang tsa bakuli li amehile haholo ka ketso ea lithethefatsi tsa hypoglycemic:

• bakuli ba nang le ho hloka pituara-adrenal ho haella,
• batho ba baholo
• batho ba sa fumaneng phepo e nepahetseng,
• bakuli ba nang le boemo bo fokolang ba kakaretso bo fokolang.

Ho bolaoa ke tlala, joala le lithethefatsi tse seng khahlanong le ho ruruha li eketsa kotsi ea hypoglycemia.

Guanethidine, reserpine, clonidine le beta-blockers li ka pata matšoao a kliniki a hypoglycemia.

Ho mafu a tšoaetsanoang a nang le febrile syndrome, ho chesa haholo, likotsi le ho kenella ka matla ha ho buuoa, ho ka hlakoloa ha Glimecomb le ho khethoa ha kalafo ea insulin. Nakong ea phekolo, ho hlokahala hore ho hlahlojoe ts'ebetso ea renal mme nako le nako (bonyane makhetlo a 2 ka selemo) ho khetholla lactate ho plasma. Tabeng ea lactic acidosis, hoa hlokahala ho hlakola lithethefatsi.

Ha u rera ho ima le nakong ea teng ha u sebelisa moriana, ho hlokahala hore o emise ho nka kalafo ea insulin.

Nakong ea kalafo, joala bo thibetsoe. Ho lokela ho ba hlokolosi ha u khanna koloi le ha u etsa mefuta e kotsi ea mosebetsi e hlokang tlhokomelo e eketsehileng, lebelo la karabelo ea kelello le koloi.

Ho sebelisana le lithethefatsi

Phello ea hypoglycemic ea Glimecomb e ntlafatsoa ke li-agents tse ling tsa hypoglycemic (mohlala, insulin, acarbose, biguanides), li-blockers secretion tsa tubular, sulfonamides ea nako e telele, li-blockers N₂histamine receptor ba khahlanong le lōna (mohlala cimetidine), coumarin anticoagulants, antifungal mahlahana (fluconazole, miconazole), inhibitors Ace (enalapril, captopril), beta-blockers, salicylates, nonsteroidal-ba khahlanong le a hlabang lithethefatsi (oxyphenbutazone, azapropazone, phenylbutazone), monoamine dihydrobenzophenanthridine inhibitors , lithethefatsi tse khahlanong le lefuba (ethionamide), fibrate (clofibrate, bezafibrate), anabolic steroids, oxytetracycline, fenfluramine, disopyramide, tetracycline, guanethidine, fluoxetine, c cyclophosphamide, allopurinol, reserpine, chloramphenicol, pyridoxine, theophylline, pentoxifylline, bromocriptine.

bohato Hypoglycemic Glimekomba fokolisa k'habone inhibitors anhydrase (acetazolamide), thiazide diuretics, lithium,-ba khahlanong le tsoeroe ke sethoathoa lithethefatsi (phenytoin), thyroid li-hormone blockers lieha k'halsiamo metjha e, steroid, barbiturates, agonists (epinephrine, clonidine), rifampicin, baclofen, chlorthalidone, diazoxide, furosemide, glucagon, isoniazid, triamteren, terbutaline, morphine, asparaginase, salbutamol, danazol, ritodrin, ka tekanyetso e phahameng - lithibela-pelehi tsa molomo, estrogens, chlorpromazine, nikotini hydrochloric asiti.

Lithethefatsi tse thibelang hematopoiesis ea masapo li eketsa menyetla ea myelosuppression, ethanol - nts'etsopele ea lactic acidosis.

Sebakeng sa ho kopantsoe le pelo glycosides, pelo ea Glimecomb e eketsa menyetla ea ho ba le ventricular extrasystole.

Nifedipine e ntlafatsa ho monya mme e liehisa ho felisoa ha metformin.

Ka tšebeliso ea nako e telele, li-cationic agents tse patiloeng ka har'a li-tubules (procainamide, amiloride, vancomycin, quinine, quinidine, digoxin, triamteren, morphine, ranitidine) li eketsa bongata ba metformin maling maling ka 60%, furosemide - ka 22%.

Metformin e theola khatello ea maikutlo le halofo ea bophelo ba furosemide ka 31 le 42.3%, ka ho latellana.

Fomati ea ho lokolloa, ho paka le sebopeho Glimecomb ®

Matlapa a ho tloha ho o mosoeu ho ea ho o mosoeu o nang le tranelate kapa 'mala o mosehla, cylindrical e boreleli, e nang le chamfer le kotsi, ho hohlanya ho lumelloa.

1 tab
gliclazide	40 mg
metformin hydrochloride	500 mg

Bahlomphehi: sorbitol, povidone, croscarmellose sodium, magnesium stearate.

Li-pcs tse 10. - liphutheloana tsa lithutsoana (6) - lipakete tsa karete.

Ketso ea pharmacological

Motsoako o kopantsoeng oa hypoglycemic bakeng sa tšebeliso ea molomo. Glimecomb® ke motsoako o kopantsoeng oa li-agents tse peli tsa molomo tsa hypoglycemic tsa sehlopha sa Biguanide le sehlopha sa sulfonylurea.

E na le liketso tsa pancreatic le extrapancreatic.

Glyclazide ke mofuta oa sulfonylurea. E hlohlelletsa secretion ea insulin ke manyeme, e phahamisa maikutlo a litharollo tsa insulin. E susumetsa ts'ebetso ea li-enzymes tse kenang ka hare - mesifa ea glycogen synthetase. E khutlisa tlhoro ea pele ea insulin secretion, e fokotsa nako ea ho qaleha ho tloha motsotso oa ho ja ho fihlela ho qala ts'ebetso ea "insulin" hape e fokotsa hyperglycemia ea postprandial. Ntle le ho ama metabolism ea carbohydrate, e ama microcirculation, e fokotsa mokokotlo oa liplatelete le bongata, e liehisa nts'etsopele ea "parietal thrombosis" E fokotsa nts'etsopele ea lefu la tsoekere le lefu la tsoekere sethaleng se sa eketseheng, le lefu la tsoekere le nang le tšebeliso ea nako e telele, ho bonahala ho fokotseha ho hoholo ha proteinuria. Ha e lebise keketseho ea boima ba 'mele, hobane e na le tšusumetso e kholo tlhorong ea pele ea insulin secretion mme ha e bake hyperinsulinemia, e thusa ho fokotsa boima ba 'mele ho bakuli ba batenya, ka mor'a lijo tse nepahetseng.

Metformin ke ea sehlopha sa Biguanides. E fokotsa tsitsipano ea tsoekere maling le ho thibela gluconeogenesis ka har'a sebete, e fokotsa ho monya ha tsoekere maling ho tsoa phepelong ea lijo le ho eketsa ts'ebeliso ea eona lithong. E fokotsa mokokotlo oa triglycerides, cholesterol le LDL (e behiloeng ka mpeng e se nang letho) ka serumeng sa mali mme ha e fetole bongata ba lipoprotein tsa methapo e fapaneng. E thusa ho tsitsisa kapa ho theola boima ba 'mele. Ha ho na le insulin maling, phello ea kalafo ha e bonahatsoe. Boitšoaro ba Hypoglycemic ha bo bake. E ntlafatsa thepa ea mali ea fibrinolytic ka lebaka la khatello ea inhibitor ea activator profibrinolysin (plasminogen).

Polelo ea lihlopha tsa nosological

Sehlooho sa ICD-10	Li-syndms tsa maloetse ho ea ka ICD-10
E mellitus ea tsoekere e sa itšetleheng ka insulin	Lefu la tsoekere la ketonuric
	Ho buseletsoa ha metabolism ea carbohydrate
	Mellitus e sa itšetleheng ka insulin
	Type 2 lefu la tsoekere
	Type 2 lefu la tsoekere
	Lefu la tsoekere le sa hlokeng insulin
	Mellitus e sa itšetleheng ka insulin
	Mellitus e sa itšetleheng ka insulin
	Khanyetso ea insulin
	Insulin e loantšang lefu la tsoekere
	Coma lactic acid e tsoekere
	Carbohydrate metabolism
	Type 2 lefu la tsoekere
	Lefu la tsoekere la Type II
	Lefu la tsoekere ha motho e le motho e moholo
	Lefu la tsoekere mellitus botsofaling
	Mellitus e sa itšetleheng ka insulin
	Type 2 lefu la tsoekere
	Type II lefu la tsoekere

Mofumahali

Tlhahiso le kabo

Kamora ho tsamaisoa ka molomo, ho monya ho phahame. Ha o nooa ka tekanyetso ea 40 mg C max ho plasma ea mali e fihlelloa kamora lihora tse 2-3 mme e fihla ho 2-3 μg / ml. Plasma protein e tlamang ke 85-97%.

Metabolism le excretion

E etselitsoe sebeteng. T 1/1 - lihora tse 8 - 20 - E qotsitsoe haholo ka sebopeho sa metabolites ke liphio - 70%, ka mala.

Ho bakuli ba tsofetseng, liphetoho tse bohlokoa tsa kliniki maemong a pharmacokinetic ha li bonoe.

Tlhahiso le kabo

Kamora ho tsamaisoa ka molomo, ho monya ke 48-52%. E kenelle ka potlako ho tsoa mokokotlong oa lijo. Absolute bioavailability (ka mpeng e se nang letho) ke 50-60%. C max ho plasma ea mali e fihlelloa kamora 1.81-2.69 h mme ha e fetele 1 μg / ml. Ho amoheloa ka lijo ho fokotsa C max ho plasma ka 40% mme e liehise katleho ea eona ka metsotso e 35. Plasma protein e tlamang e ke ke ea qojoa. Metformin e khona ho bokellana liseleng tse khubelu tsa mali.

T 1/2 ke lihora tse 6.2. E pepesitsoe ke liphio, haholo-holo tse sa fetoheng (glomerular filtration le secretion ea tubular) le ka mala (ho fihlela 30%).

Litheko makaleng a litlama a litsobotsi tsa meriana Moscow

Lebitso la lithethefatsi	Letoto	E loketseng	Theko ea 1 unit.	Theko ka pakete e ngoe le e ngoe, itlotsa ka eona.	Maphodisa
Glimecomb ® matlapa 40 mg + 500 mg 40 mg + 500, 60 likhomphutha.

474,00 K'hemisteng 400.00 K'hemisteng Glimecomb ®
matlapa a 40 mg + 500 mg 40 mg + 500, li-pcs tse 30.

Tlohela maikutlo a hau

Lenaneo la Hona Joale la Litaba tsa Tlhokahalo, ‰

Setifikeiti sa ho ingolisa Glimecomb ®

• LSR-009886/09

Webosaete ea semmuso ea k'hamphani RLS ®. Encyclopedia e ka sehloohong ea lithethefatsi le thepa ea bongaka ba semmuso ea marang-rang a Russia. Lenane la lithethefatsi Rlsnet.ru le fa basebelisi monyetla oa ho fumana litaelo, litheko le litlhaloso tsa lithethefatsi, tlatsetso ea lijo, lisebelisoa tsa bongaka, lisebelisoa tsa bongaka le lihlahisoa tse ling. Tataiso ea meriana e kenyelletsa tlhahisoleseling mabapi le sebopeho le mofuta oa tokollo, ts'ebetso ea meriana Sesebelisoa sa lithethefatsi se na le litheko tsa meriana le lihlahisoa tsa meriana ho la Moscow le metseng e meng ea Russia.

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Lintho tse ling tse ngata tse khahlang

Litokelo tsohle li sirelelitsoe.

Ts'ebeliso ea thepa ea khoebo ha e lumelloe.

Tlhahisoleseling ena e etselitsoe litsebi tsa bongaka.

Kopo

Glimecomb e khothalletsoa hore e sebelisoe ho bakuli ba nang le lefu la tsoekere la mofuta oa 2. Ho bohlokoa hore sethethefatsi sena se etselitsoe mofuta o joalo oa lefu lena ha ts'ebetso ea 'mele le' mapa oa lijo o hlophisitsoeng ka kotloloho o sa tlise sephetho se nepahetseng. Sena se bolela hore sethethefatsi sena se laetsoe haeba ho sa sebetsanoe hantle le kalafo e rarahaneng, e kopanya lithethefatsi tse peli (hangata li arotsoe ka bongata le metformin le gliclazide) hammoho le ts'ebetso ea mmele le lijo.

Nakong ea kalafo le Glimecomb, ho lekola khafetsa boemo ba tsoekere ba mokuli pele le ka mor'a lijo ho hlokahala (tlhokomelo e khethehileng e lokela ho lefuoa bekeng ea pele ea kamohelo).

Lokolla liforomo

Glimecomb e na le foromo e le 'ngoe ea ho lokolla ka mokhoa oa matlapa. Moriana o arotsoe ka mokhoa oa ho paka ka lihlopha tse latelang:

• ka libotlolong tsa polasetiki ka liphutheloana tsa karete. Vial e le 'ngoe e kanna ea ba le matlapa a 30, 60 kapa 120,
• ka lebokoseng la karete e nang le lithupa tsa matlapa a 10 ho e le 'ngoe. Pakete e le 'ngoe e na le lilakane tse 6,
• ka lebokoseng la karete le nang le lithupa tsa matlapa a 20 ho e le 'ngoe. Sephutheloana se le seng se na le lithutsoana tse 5.

Matlapa ka boyona a ka sebopeho sa silinda e sephara, hangata e tšoeu (beige, 'mabole kapa e mosehla e loketse). Lipilisi li na le kotsi le bevel. Sebopeho sa Glimecomb se kenyelletsa metformin le hydrochloride ka bongata ba 500 mg, hammoho le glycoslide 40 mg. Ntle le moo, sodium ea povidone, magnesium stearate, sorbitol le croscarmellose e teng ka bongata.

Matšoao a sethethefatsi Glimecomb ®

• mofuta oa lefu la tsoekere la 2 lefu la tsoekere (le sa itšetlehang ka insulin) ka ho se sebetse hantle kalafo ea ho ja, boikoetliso le kalafo e fetileng ka metformin kapa gliclazide,
• phetisetso ea kalafo ea nakong e fetileng ka lithethefatsi tse peli (metformin le gliclazide) ho bakuli ba nang le mofuta oa lefu la tsoekere la mofuta oa 2 mellitus (o sa itšetleheng ka insulin) o nang le boemo ba tsoekere ea mali le bo laoloang hantle.

Khoutu tsa ICD-10

Khoutu ea ICD-10	Pontšo
E11	Type 2 lefu la tsoekere

Litaelo tsa ho sebelisoa

Glimecomb e nkiloeng ka molomo, hang kamora ho ja kapa le eona, ho latela litekanyetso. Nakong ea kalafo ka litafole, o lokela ho latela lijo tse tlase tsa carb tse khothalletsoang ke litsebi, tse lokelang ho kenyelletsa lijo tsa hoseng. Tekanyetso ea matlapa ha ea lokela ho nka feela tekanyo ea lefu la tsoekere la mofuta oa bobeli, empa hape le boemo ba maikutlo le ba 'mele ba mokuli. Hape, liphetoho leha e le life tsa ho ja li hloka tšebelisano le ngaka (ho itima lijo le ho tahoa li sa sebelisoe) ha li amohelehe. Hoa hlokahala ho boloka moriana ona sebakeng se omileng se lefifi ka mocheso o sa feteng likhato tse 25 tsa Celsius. Bophelo ba Shelf lilemo tse 2.

Ho lokela ho hopoloa hore lihlahisoa tsa sulfonylurea tse fumanehang moriring li ka baka hypoglycemia. Ho qoba sena, ho hlokahala hore u khethoe ka hloko bakeng sa tekanyo le lijo bakeng sa nyeoe ka 'ngoe. Nakong ea kalafo, tlhokomelo e khethehileng e lokela ho nkuoa ha ho khannoa koloi le mosebetsi o hlokang ho tsepamisa maikutlo le ho eketsa tlhokomelo.

Melemo ea litekanyetso

Moriana o nooa ka molomo nakong ea lijo kapa hang ka mor'a lijo. Tekanyetso ea lithethefatsi e khethoa ke ngaka ka bonngoe ho mokuli ka mong, ho latela boemo ba tsoekere ea mali.

Tekanyetso ea pele ke hangata matlapa a 1-3 / letsatsi le khetho ea butle-butle ho fihlela puseletso e tiileng ea lefu lena e fihlella. Sekhahla se phahameng sa letsatsi le letsatsi ke matlapa a 5.

Ka tloaelo moriana o nooa makhetlo a 2 / ka letsatsi (hoseng le mantsiboea).

Litlamorao

Litlamorao tse sa rateheng tse ka sebetsanoang le ho etsoa ha Glimecomb hangata li bakoa ke ho fetella kapa ho se lumellane ha hae le 'mele oa mokuli o amehang ka ho khetheha. Mme litaba tse tsoang ho sulfonylurea derivatives li eketsa kotsi ea palo e kholo ea litla-morao. Khetho ea lethal e sa sebetseng bakeng sa mokuli e aparetsoe ke kholo ea lactic acidosis, e tsamaeang le migraines, bofokoli bo sa khaotseng, ho otsela ho tebileng, hammoho le bohloko bo otlang ka mpeng le ho fokotseha ha khatello ea methapo ea methapo.

Tse latelang ke litlamorao tse sa batleheng ha o nka Glimecomb:

• nts'etsopele ea hypoglycemia le lactocidosis e nang le matšoao ohle a bohloko,
• ponahalo ea lets'ollo le ho hlasimoloha,
• maikutlo a lulang a sa thabise ka mpeng ea mpa,
• fokotseha takatso ea tloaelo,
• khafetsa khafetsa, tatso ea mali molomong le 'metso,
• Nts'etsopele ea maloetse a tebileng a sebete (hepatitis, jj.) ha e fumanehe
• allergic reaction on the dikarolo tsa sebopeho (urticaria, ho hlohlona, ​​lihlahala,
• bokhubelu, mefuta e fapaneng ea mehoma),
• ho na le maemo a ho senyeha hoa pono ha u ntse u nka Glimecomb.

Haeba u na le matšoao a ka holimo, u lokela ho etela setsebi hang-hang.

Lifekthering tse etellang pele tsa Russia, theko ea Glimecomb e fapana ho tloha ho li-ruble tse 200 ho isa ho tse 600, ho latela sephutheloana le palo ea litafole tse ho sona, hammoho le ho mofani oa thepa le sebaka sa thekiso. Litsenyehelo tsena tsa lithethefatsi li etsa hore e be theko e tlase bakeng sa karolo e pharalletseng ea baahi, ka hona e hlokoa 'marakeng oa meriana. Kahoo theko e tloaelehileng mabenkeleng a marang-rang bakeng sa matlapa a Glimecomb ke li-ruble tse 40 mg + 500 mg 450 ka sephutheloana, tse nang le matlapa a 60. Lifekthering tsa marang-rang, theko ea lithethefatsi bakeng sa matlapa a 60 e tla ba li-ruble tse 500-550.

Li-analogu tsa Glimecomb ke litlhare tse latelang:

• Gliformin (li-ruble tse ka bang 250 bakeng sa matlapa a 60), mookotaba oa ts'ebetso o ts'oana le oa Glimecomb, sebopeho se tšoana, empa ho ba teng ha insulin ho etsa hore lithethefatsi tsena li se ke tsa rateha,
• Diabefarm (bakeng sa matlapa a 60, u tla tlameha ho lefa li-ruble tse ka bang 150). E na le khatello e matla ea glyclazide - 80 mg, e etselitsoeng ho felisa mathata a tšoanang le Glimecomb.
• Gliclazide MV (theko e tloaelehileng ea matlapa a 60 ke li-ruble tse 200). E na le sebopeho se fapaneng le Glimecomb, e na le 30 mg feela ea glycoslazide. Matšoao a sebelisoang a tšoana le a moriana oa mantlha.

Bongata

Haeba ho na le overdose ea Glimecomb, lactacidosis le hypoglycemia li etsahala. Ho loantša maemo ana, hangata ho buuoa ka hemodialysis. Glycemia e hloka ts'ebeliso ea tsoekere kapa tharollo ea tsoekere kahare (ka bonolo kapa ka tekano). Maemong a matla haholo, ho fihlela ho lahleheloa ke ho tseba, tharollo ea glucose ea 50% e lokela ho fanoa (e ka nkeloa sebaka ke glucagon). Hang ha mokuli a hlaphoheloa kelellong, ho hlokahala hore a mo fe lijo tse nang le lik'habohaedreite e ngata ho thibela tsoelo-pele ea hypoglycemia.

Hape, haeba tšebeliso e mpe ea lithethefatsi e etsahala ntle le mathata a tebileng, mokuli a ka ikutloa a sa phuthuloha ka mokhoa oa ho tsitsipana ho fihlela ho akheha, ho nyekeloa ke pelo, ho phaellana le lefu la lets'ollo, hammoho le ho opa ha hlooho. Maemong ana, o lokela ho sebelisa thuso ea pele hang-hang. Lapeng, ho hlokahala hore o hlatsoe mala, 'me hang-hang u tlose lithethefatsi ka mpeng ea lijo, ebe ho latela lijo tse nang le lik'habohaedreite tse ngata. Haeba ho hlokahala, ho kena sepetlele kamora nako ho ka etsahala tlasa taolo e sa feleng ea setsebi.

Ho sebetsa ha sethethefatsi sena holim'a taolo ea tsoekere ea mali ho lefu la tsoekere la mofuta oa bobeli, hammoho le litšenyehelo tsa sona tse itekanetseng, ho etsa hore sethethefatsi se tummeng 'me se fuoe litlhahlobo tse ngata tse ntle. Empa u se ke oa lebala ka litlamorao tse fanoeng ke moriana ona. Ke ka lebaka la lenane le leholo la litlamorao tse sa rateheng moo ho fumanoang litlhahlobo tse mpe tsa bakuli. Ka tlase ke litlhahlobo tse ling mabapi le lipilisi tsena:

Glimecomb, joalo ka tloaelo e bontša, ke setlhare se tsebahalang haholo kalafong ea lefu la tsoekere la mofuta oa 2. Ho kopana ha theko, boleng le ts'ebetso e phahameng ho etsa hore matlapa a khahle haholo mebarakeng ea meriana.

Litla-morao

Ho tloha tsamaisong ea endocrine: hypoglycemia (e khahlanong le mofuta oa dosing le lijo tse sa lekaneng) - hlooho ea hlooho, ho ikutloa a khathetse, tlala, ho eketsa ho fufuleloa, bofokoli bo matla, ho omella, ho tsejoa, ho hokahana ha metsamao, mathata a nakoana a ts'ebetso ea methapo, ho tsoela pele ha hypoglycemia, tahlehelo ea boitšoaro e ka ba teng, ho lahleheloa ke kelello.

Ho tloha ka lehlakoreng la metabolism: maemong a mang - lactic acidosis (bofokoli, myalgia, mathata a ho hema, ho otsela, bohloko ba ka mpeng, hypothermia, ho fokotseha ha khatello ea mali, bradyarrhythmia).

Ho tsoa ho ts'ebetso ea tšilo ea lijo: dyspepsia (ho nyekeloa, lets'ollo, maikutlo a boima ho epigastrium, tatso ea "metallic" molomong), ea fokotseha takatso ea lijo (ho teba ha maikutlo ana a fokotseha ka moriana o ntse o ja), ka seoelo hepatitis, cholestatic jaundice (ho tlosoa hoa lithethefatsi hoa hlokahala) , mosebetsi o eketsehileng oa hepatic transaminases, alkaline phosphatase.

Ho tsoa ho tsamaiso ea hemopoietic: ka seoelo - thibelo ea masapo a hematopoiesis (anemia, thrombocytopenia, leukopenia).

Litla-morao: Ho otla, urticaria, lekhopho la maculopapular.

Tse ling: ho sitisoa ha pono.

Maemong a litla-morao, tekanyetso e lokela ho fokotsoa kapa sethethefatsi se emisoe ka nakoana.

Litla-morao tse tloaelehileng tsa derivatives ea sulfonylurea: erythropenia, agranulocytosis, hemolytic anemia, pancytopenia, alculgic vasculitis, ho se sebetse hantle hoa sebete.