Matlapa a Tricor: matšoao a ts'ebeliso, analogues le theko

Tricor ke sethethefatsi sa hypolipidemic se nang le phello ea uricosuric le antiplatelet. E fokotsa cholesterol e felletseng ea mali ka 20-25%, TG ea mali ka 40-45% le uricemia ka 25%. Ntho e sebetsang ke Fenofibrate.

E fokotsa mali triglycerides le (ho isa tekanyong e nyane) k'holeseterole. E thusa ho fokotsa litaba tsa VLDL, LDL (ho isa tekanyong e nyane), e eketsa litaba tsa anti-atherogenic HDL. Mokhoa oa ts'ebetso ha o utloisisoe ka botlalo.

Kameho e maemong a TG e amana haholo le ts'ebetso ea lipase ea enzyme lipoprotein lipase. Kamoo ho bonahalang kateng, fenofibrate e boetse e sitisa motsoako oa mafura a acid, e etsa hore keketseho ea palo ea li-receptor tsa LDL bokong, e ferekanye khopolo ea cholesterol.

Nakong ea lithuto tsa bongaka, ho ile ha hlokomeloa hore ts'ebeliso ea Tricor e fokotsa cholesterol e felletseng ka 20-25% le triglycerides ka 40-55% ka keketseho ea HDL-C ka 10-30%. Ho bakuli ba nang le hypercholesterolemia, moo boemo ba Chs-LDL bo fokotsoang ke 20-35%, ts'ebeliso ea fenofibrate e lebisitse ho fokotseha ha litekanyetso: kakaretso ea Chs / Chs-HDL, Chs-LDL / Chs-HDL le moo B /apo AI, tse tšoaeang kotsi ea atherogenic.

Nakong ea ts'ebeliso ea lithethefatsi, li-deposits tse eketsehileng tsa k'holeseterole (tendon le tuberous xanthomas) li ka fokotseha haholo le ho nyamela ka ho felletseng.

Monyetla o eketsehileng bakeng sa batho ba nang le hyperuricemia le dyslipidemia ke phello ea uricosuric ea ntho e sebetsang, e lebisang ho fokotseha hoa khatello ea uric acid ke hoo e ka bang 25%.

Ho na le bopaki ba ho fokotseha ha pokello ea liplatelese tse bakoang ke adenosine diphosphate, epinephrine le arachidonic acid.

Matšoao a ho sebelisoa

Ke eng e thusang Tricor? Ho latela litaelo, sethethefatsi se fanoa maemong a latelang:

• Hypercholesterolemia le hypertriglyceridemia e arotsoeng kapa e tsoakiloeng (mofuta oa dyslipidemia IIa, IIb, III, IV, V) ka ho se sebetse hantle ha mekhoa ea kalafo e seng ea lithethefatsi (ho fokotsa boima ba 'mele, ho eketsa mesebetsi ea mmele), haholoholo ha ho na le mabaka a kotsi a amanang le dyslipidemia - khatello ea methapo ea mali le ho tsuba,
• Hyperlipoproteinemia ea maemong a tlase, maemong ao hyperlipoproteinemia e phehellang, leha ho na le kalafo e sebetsang ea lefu lena le tlase (mohlala, dyslipidemia ho lefu la tsoekere mellitus).

Moriana o laetsoe hammoho le lijo tsa cholesterol le karolo ea kalafo e rarahaneng.

Litaelo tsa tšebeliso Tricor 145 mg, litekanyetso

Letlapa la Tricor 145 mg le nkuoa ka molomo, ho sa tsotelehe lijo (e felletseng), e hlatsuoa ka metsi a hloekileng. Moriana ka tekanyetso ea 160 mg e nkuoa le lijo.

Litekanyetso tse tloaelehileng, ho latela litaelo tsa ts'ebeliso, Letlapa le le leng la Tricor 145 mg 1 nako ka letsatsi. Moriana o laetsoe nako e telele, ha o ntse o ja.

Melemo ea bana e behiloe ke ngaka, tekanyetso e tloaelehileng e baloa ho latela boima ba 'mele ba ngoana - 5 mg / kg ka letsatsi.

Bakuli ba nkang letlapa le le leng la 1 la Fenofibrate 160 mg 1 nako ka letsatsi ba ka fetohela ho ho nka TRICOR 145 mg ntle le tokiso ea tekanyetso e eketsehileng.

Batho ba baholo ha ba hloke phetoho ea litekanyetso. Ka ho se sebetse hantle ke moriana, ho na le lethalinyana le fokotsoang.

Litaelo tse khethehileng

Ha ho se na phello e khotsofatsang, kamora likhoeli tse 3-6 tsa ho sebelisa moriana, lingoloa tse ling kapa tse ling li ka phekoloa.

Ho khothalletsoa ho beha leihlo tšebetso ea lipapatso tsa "hepatic" likhoeli tse ling le tse ling tse tharo selemong sa pele sa kalafo, khefu ea nakoana ho ts'ebetso ea bona haeba ts'ebetso ea bona e eketseha, le ho qheleloa ka thoko ho lithethefatsi tsa hepatotoxic kalafong e tšoanang.

Ho batho ba nang le hyperlipidemia ba ntseng ba phekoloa ka lithethefatsi tsa estrogen kapa ba nka lithibela-pelehi tsa lihormone tsa molomo, ho kenyelletsa le estrogens, sesosa sa mantlha kapa sa bobeli sa ho thehoa ha hyperlipidemia se lokela ho tsejoa, hobane keketseho ea lipidid ea lipid e ka etsahala ka lebaka la tšebeliso ea li-estrogens.

Litlamorao

Taeo e hlokomelisa ka monyetla oa ho hlahisa litla-morao tse latelang ha u khetha Tricor:

• Sisteme ea cymphatic / potoloho ea mali: ka seoelo - keketseho ea litaba tsa lisele tse tšoeu tsa mali le hemoglobin,
• Sistimi ea tšilo ea lijo: khafetsa - bohloko ba ka mpeng, ho hlatsa, ho nyekeloa, ho ruruha le ho ts'oaroa ka nako e telele, ka linako tse ling - linyeoe tsa pancreatitis,
• Sistimi ea musculoskeletal le tishu e sebetsang: ka seoelo - myositis e senya myalgia, bofokoli, mesifa ea mesifa, haholo - rhabdomyolysis,
• Sebete: khafetsa - keketseho e leka-lekaneng ea ho hlaseloa ha lipilisi tsa serum, ka linako tse ling - ho thehoa ha methapo ea mahlo, ho sa atisehe haholo - linako tsa lefu la hepatitis (maemong a matšoao - jaundice, ho hlohlona - liteko tsa laboratori lia hlokahala, maemong a netefatsang ts'oaetso, lithethefatsi li hlakotsoe),
• Mokhoa oa tsamaiso ea methapo: ka seoelo - hlooho e bohloko, ho senyeha hoa thobalano,
• Ts'ebetso ea pelo: ka linako tse ling - venous thromboembolism (vein thrombosis e tebileng, pulmonary embolism),
• Letlalo le mafura a ikhethileng: ka linako tse ling - ho hlohlona, ​​ho ruruha, ho ts'oaroa hoa photosensitivity, urticaria, ka seoelo - alopecia, ka seoelo haholo - photosensitivity e hlahang ka erythema, ho etsoa ha li-nodule kapa malepa libakeng tsa letlalo tse pepesetsoeng mahlaseli a kotsi a UV kapa khanya ea letsatsi (ho maemong a le mong - kamora tšebeliso ea nako e telele ntle le mathata a letho),
• Ts'usumetso: ka seoelo - pneumopathy ea lipakeng,
• Lithuto tsa laboratori: ka linako tse ling - maemo a eketsehang a urea le creatinine ho serum.

Contraindication

Ho hatelloa ho fana ka Tricor maemong a latelang:

• Lefu le matla la sebete, le tsamaeang le litho tse sa sebetseng hantle tsa setho,
• Ho hloleha ha sebete
• Ho hloleha ha methapo ea kutlo,
• Acanc pancreatic kuvimba kapa pancreatitis e sa foleng.
• Mafu a gallbladder ka mokokotlo oa eona,
• Bokhachane le pelehi.
• Tlas'a lilemo tse 18
• Hypersensitivity ea motho ka mong ho likarolo tsa moriana.

E laetsoe ka hloko ho batho ba nang le lefu la hepatic le / kapa renal, bakeng sa hypothyroidism, bakuli ba sebelisang joala hampe, bakuli ba tsofetseng, ba nang le nalane ea mafu a mesifa ea lefutso, ha ba ntse ba nka li-anticoagulants tsa molomo, HMG-CoA reductase inhibitors.

Bongata

Matšoao a overdose ha a hlalosoe ka litaelo. Hajoale ha ho na tlhaiso-leseling ea bongaka e mabapi le lithethefatsi tse fetang tekano.

Motsoako ona ha o tsejoe. Phekolo ke letšoao. Hemodialysis ha e sebetse.

Li-Analogs tsa Tricor, theko ea meriana

Haeba ho hlokahala, o ka kenya Tricor sebakeng sa analogue ea ntho e sebetsang - tsena ke lithethefatsi:

1. Fenofibrate Canon (ho tloha ho li-ruble tse 320.90),
2. Lipantil (ho tloha ho 845.00 rub),
3. Lipantil 200 M (ho tloha li-ruble tse 868.80).

E tšoanang ka ketso:

Ha u khetha li-analogues, ho bohlokoa ho utloisisa hore litaelo tsa tšebeliso ea Tricor 145 mg, theko le litekanyetso ha li sebetse lithethefatsing tse tšoanang. Ho bohlokoa ho fumana tlhahlobo ea ngaka le ho se etse phetoho e ikemetseng ea lithethefatsi.

Theko ea meriana ea litlama e Moscow le Russia: Matlapa a Tricor 145 mg 30 - ho tloha ho li-ruble tse 864 ho isa ho 999, ho latela li-pharmacies tsa 729.

Boloka sebakeng se ommeng ka lithemparetjha ho fihla ho 25 ° C. Qoba hole le bana. Bophelo ba Shelf ke lilemo tse 3.

Maemo a ho ajoa ho tloha litlolong tsa litlhare, ke ngaka.

Maikutlo a 3 bakeng sa "Tricor 145 mg"

Tricor 145 ha e ntumelle, ka mor'a ho e nka ka likhoeli tse peli, bohloko bo neng bo le teng kahareteng ea 'mele bo ile ba matlafala, bofokoli ba mesifa ka kakaretso (Ke ile ka ba le lefu la hemorrhagic lilemo tse 8 tse fetileng, li-paresis tse ka lehlakoreng le letona li phehella hona joale) Ha ho ntlafatso e bonoang, ke bofokoli bo tšabehang feela' meleng kaofela le lethargy.

Matla a sethethefatsi a utloahala. Ba bang ba boemong bo sa thabiseng ho pholletsa le 'mele. Qetellong ea kamohelo, ntho e ngoe le e ngoe ea feta. Liphetho tsa eona, ka thuso ea Tricorr, ke hloka ho li fihlela - ke li finyeletse. Pheta-pheto ea hemophthalmus (intraocular hemorrhage) e ile ea qojoa

Ha kea ka ka nyahlatsa kholiseho ka lipilisi tsena - nakong ea tsamaiso, ho utloa bohloko.

Sokolla foromo le sebopeho

Tricor e fumaneha ka mefuta e latelang ea litekanyetso:

• matlapa a koahetsoeng ka filimi, 145 mg: oblong, e tšoeu, e nang le "logo" ea k'hamphani ka lehlakoreng le leng la letlapa le mongolo o ngotsoeng "145" ka lehlakoreng le leng (li-pcs tse 10. ka lilakane, lebokoseng la 1, 2, 3, 5, 9 kapa 10 lithutsoana, li-PC tse 14 ka har'a marang-rang, lilokiso tsa likarete tse 2, tse 6 kapa tse 7 bakeng sa lipetlele.
• matlapa a koahetsoeng ka filimi, 160 mg: oblong, e tšoeu, e nang le "logo" ea k'hamphani ka lehlakoreng le leng la letlapa le mongolo o ngotsoeng "160" ka lehlakoreng le leng (li-pcs tse 10. ka lilakane, lebokoseng la karete 1, 2, 3, 4, 5, 9. kapa marang-rang a 10, li-pcs tse 14 ho lilakane, likhaketeng tse 2, tse 6 kapa tse 7.

Sekete se seng le se seng se na le litaelo tsa tšebeliso ea Tricor.

Sebopeho ka ho penta e koahetsoeng ka lifilimi:

• ntho e sebetsang: fenofibrate (e entsoe ka mokhoa oa nanoparticles) - 145 mg kapa 160 mg,
• likarolo tse thusang: sodium lauryl sulfate, sodium stearyl fumarate, crospovidone, colloidal silicon diabolic, scriptusate sodium, sucrose, lactose monohydrate, microcrystalline cellulose, hypromellose, magnesium stearate, povidone,
• Filimi sheath: Opadry OY-B-28920 (titanium dioksidi, talc, xanthan gum, joala ba polyvinyl, soy lecithin).

Mofumahali

Fenofibrate e bua ka lintho tse tsoang ho fibroic acid. Mochine oa ketso ea ona o amahanngoa le ts'ebetso ea RAPP-alpha (alpha receptors e hlahisitsoeng ke li-proliferators tsa peroxisome). Ka lebaka la ts'ebetso ea RAPP-alpha, lipolysis ea lipoprotein ea atherogenic e matlafatsoa mme tlhahiso ea tsona ho tsoa ho plasma e potlakisitsoe. Sena se boetse se lebisa keketseho ea ho hlophisoa ha li-apoproteins A-1 le A-2 (Pali A-1 le Apo A-2). Ka lebaka la ketso ena, litaba tsa karoloana ea LDL (lipensense tse tlase tsa methapo ea methapo) le VLDL (lipensensele tse tlase haholo) li ea fokotsoa mme litaba tsa karolo ea HDL (high density lipoprotein) lia eketseha. Fenofibrate e eketsa sekhahla sa LDL excretion mme e theola litaba tsa likarolo tse nyane le tse teteaneng tsa LDL, keketseho ea palo eo e bonoang ho bakuli ba nang le atotic lipid phenotype (haholo-holo khafetsa, mathata a joalo a hlaha ho batho ba leng kotsing ea lefu la pelo).

Ka lebaka la lithuto tsa bongaka, ho ile ha bontšoa hore fenofibrate e fokotsa khatello ea li-triglycerides ka 40-55% le cholesterol e felletseng ka 20-25% ka keketseho ea cholesterol le HDL ka 10-30%. Ho bakuli ba nang le hypercholesterolemia e nang le k'holeseterole e theotsoeng le LDL (ka 20- 35%) nakong ea ts'ebeliso ea fenofibrate, mefuta e latelang ea karo-karolelano e fokotsoe: "LDL-cholesterol / HDL-cholesterol", "whole cholesterol / HDL-cholesterol", "Apo B / apo A-1 "(litekanyetso tse thathamisitsoeng ke matšoao a kotsi ea atherogenic).

Kaha Tricor e ama haholo triglycerides le LDL cholesterol, ts'ebeliso ea eona ho hypercholesterolemia, e tsamaeang le ho se tsamaisane le hypertriglyceridemia (ho kenyeletsa hyperlipoproteinemia, ka mohlala, mofuta oa 2 lefu la tsoekere), e nepahetse ka botlalo.

Nakong ea ts'ebeliso ea fenofibrate, ho fokotseha ho hoholo le ho nyamela ho felletseng ha li-deposits tse eketsehileng tsa k'holeseterole (tuberous le tendon xanthomas) hoa khoneha. Bathong ba nang le boemo bo phahameng ba fibrinogen, ho fokotseha ho hoholo hoa letšoao lena ho bonoa tlasa ts'usumetso ea fenofibrate (joalo ka ho bakuli ba nang le bongata ba lipoprotein). Boemo ba letšoao le leng la ho fokola, protheine ea C e sebetsang, le eona e fokotseha ka kalafo ea fenofibrate.

Har'a lintho tse ling, Tricor o fana ka phello ea uricosuric le ho fokotsa khatello ea uric acid ka 25%, e leng monyetla o eketsehileng bakeng sa bakuli ba nang le hyperuricemia le dyslipidemia.

Litekong tsa liphoofolo, hammoho le teko ea bongaka ea lithethefatsi, ho ile ha bontšoa hore e fokotsa pokello ea liplatele e bakoang ke epinephrine, arachidonic acid le adenosine diphosphate.

Mofumahali

Litafole tsa Tricor ka tekanyetso ea 160 mg li na le bioavailability e phahameng ho feta mefuta ea pele ea litekanyetso tsa fenofibrate.

Khokahano e kholo ea plasma e fihlella ka mor'a lihora tse 2-5 (matlapa a 145 mg) kapa lihora tse 4-5 (matlapa a 160 mg). Ha e ea itšetleha ka lijo tse fumanehang 'me ka tšebeliso ea nako e telele ea lithethefatsi e lula e tsitsitse ho sa tsotelehe likarolo tsa motho ka mong.

Kamora ho nka Tricor, fenofibrate ea pele ho plasma ea mali ha e fumanoe. E hydrolyzed ke litheko. Metabolite e ka sehloohong ea plasma ea lithethefatsi ke fenofibroic acid, e fetang 99% e tlameletsoeng liprotheine tsa plasma (albin). Fenofibrate ha e kenelle ho microsomal metabolism mme ha se karolo e ka tlase ea enzyme ea CYP3A4.

Bophelo ba halofo ke lihora tse 20. Mokhoa o ka sehloohong oa excretion o teng ka moroto (ka mokhoa oa conjugate ea glucuronide le fenofibroic acid). Fenofibrate e batla e felisitsoe ka botlalo matsatsing a 6. Ho batho ba tsofetseng, ho hlakisoa ka botlalo ha fenofibroic acid ha ho fetohe.

Litlamorao ha li bonoe ka bobeli kamora tekanyetso e le 'ngoe ea moriana, le ka lebaka la tšebeliso ea nako e telele. Hemodialysis bakeng sa ho tlosa fenofibrate ha e na thuso (ka lebaka la tlamo e phahameng ea liprotheine tsa plasma).

Contraindication

• ho hloleha ho hlaba hoa ho teba ha maikutlo,
• mats'oao a nalane ea lefu la gallbladder,
• ho hloleha ha sebete (ho kenyeletsa hepatitis e sa khaotseng ea tšimoloho e sa tsejoeng le cirrhosis ea biliary),
• pancreatitis e hlobaetsang kapa e sa foleng, ntle le maemong a pancreatitis e mpe ka lebaka la hypertriglyceridemia e matla,
• nalane ea botoro ea peanut, soya lecithin, phaenapole kapa lihlahisoa tse amanang ho anamnesis (ka lebaka la kotsi ea hypersensitivity),
• lactase enzyme ea haella, congenital galactosemia, malabsorption ea galactose le glucose (kaha matlapa a na le lactose),
• isomaltase / sucrase enzyme ea haella, congenital fructosemia (kaha sucrose ke karolo ea matlapa),
• nalane ea ho nka lifoto kapa ho hlasimolla linthong tsa kalafo kalafong ea ketoprofen kapa fibrate,
• lebone
• bana le bacha ba ka tlase ho lilemo tse 18,
• hypersensitivity ho fenofibrate, hammoho le likarolo tse ling tsa lithethefatsi.

Setsoalle (Tricor e sebelisoa ka hlokolosi):

• hypothyroidism
• nalane e boima ea maloetse a mesifa ea liphatsa tsa lefutso,
• tsamaiso e tšoanang ea hydroxymethylglutaryl coenzyme A reductase inhibitors (HMG-CoA reductase) kapa anticoagulants ea molomo,
• tlhekefetso ea joala
• botsofali
• nako ea kemaro.

Tricor: Litaelo tsa ts'ebeliso (litekanyetso le mokhoa)

Tricor e lokela ho nkuoa ka molomo, ho sa tsotelehe nako ea lijo. Letlapa le tlameha ho metsoa le felletse ntle le ho hlafuna, ho hlatsuoa ka metsi a lekaneng.

Ho hlokahala ho tsoela pele ho latela mokhoa o khethehileng oa hypocholesterolemic ja lijo, tse neng li laetsoe pele ho qala kalafo ka moriana.

Motsoako o khothalelitsoeng ke letlhare le le leng (145 mg kapa 160 mg) hang ka letsatsi. Bakuli ba kileng ba nka fenofibrate ho lipilisi tsa 200 mg kapa matlapeng a 160 mg, khalase e le 'ngoe kapa Letlapa le le leng hang ka letsatsi, ba ka fetoha ho nka letlapa le le leng la Traicor 145 mg kapa 160 mg ntle le tokiso ea tekanyetso e eketsehileng.

Bakeng sa batho ba baholo (ka ts'ebetso e tloaelehileng ea renal), moriana o laetsoe ka tekanyetso e tloaelehileng.

Katleho ea kalafo e lokela ho hlahlojoa ke khatello ea li-triglycerides, cholesterol le LDL serum.Haeba kamora kalafo ea likhoeli tse 'maloa (hangata kamora likhoeli tse tharo) ho se na sephetho, ho bohlokoa ho nka qeto mabapi le tšoaneleho ea kalafo le ho fana ka lingoloa tse lumellanang le tse ling.

Litlamorao

Litlamorao tse sa rateheng tsa Traicor tse fumanoeng nakong ea lithuto tse laoloang ke placebo:

• tsamaiso ea tšilo ea lijo, lesapo la mokokotlo le lefu la biliary: khafetsa - matšoao le matšoao a mafu a ka mpeng: ho hlatsa, ho nyekeloa le pelo, bohloko ba ka mpeng, lefu la lets'ollo, ho eketseha ha lipilisi tsa sebete, hangata - hepatitis,
• tsamaiso ea methapo ea pelo: khafetsa - methapo e tebileng ea methapo ea methapo e tlase, pulomboary ea polmonary,
• tsamaiso ea methapo: hangata - hlooho e bohloko, ka seoelo - ho tsekela, ho tepella ho eketsehileng,
• Sistimi ea musculoskeletal: hangata - ho senyeha ha mesifa (myositis, mesifa ea mokokotlo, senya myalgia, mesifa ea mesifa),
• Mokhoa oa ho beleha: khafetsa - ho hloka thari,
• tsamaiso ea mali le methapo: ka seoelo - ho fokotseha ha hemoglobin, ho fokotseha ha palo ea lisele tse tšoeu tsa mali,
• sesole sa mmele: ka seoelo - hypersensitivity,
• letlalo le mafura a ikhethileng: hangata - ho senyeha, ho hlohlona, ​​urticaria, ka seoelo - photosensitivity, ho lahleheloa ke moriri,
• liteko tsa laboratori: khafetsa - keketseho ea serum creatinine, ka seoelo - keketseho ea khatello ea mali ea urea nitrogen.

Liphetoho tse mpe tsa Traicor tse tlalehiloeng nakong ea ts'ebeliso ea morao-rao:

• sebete le pampiri ea biliary: mathata a cholelithiasis (cholangitis, cholecystitis, biliary colic), jaundice,
• tsamaiso ea phefumoloho:
• musculoskeletal system: rhabdomyolysis,
• letlalo le mafura a potolohileng: liphetoho tse matla tsa letlalo (chefo e tsoang ho cyermal necrolysis, erythema multiforme).

Litaelo tse khethehileng

Pele o qala fenofibrate, ho hlokahala hore o tsamaise kalafo e nepahetseng ho felisa sesosa sa hypercholesterolemia ea mantlha ho mafu a kang hypothyroidism, dysproteinemia, mofuta o sa laoloeng oa lefu la tsoekere la 2 lefu la tsoekere, lephrotic syndrome, lefu le thibang sebete le lefu la lithethefatsi.

Ho bakuli ba nang le hyperlipidemia, ho nka lithibela-mafu tsa estrogen tse nang le estrogen, ho eketseha ha lipid ho ka bakoa ke tšebeliso ea estrogen, ka hona, ho hlokahala pele ho tseba mofuta oa hyperlipidemia (ea mantlha kapa ea sekondari).

Selemong sa pele, likhoeli tse ling le tse ling tse 3 le nako le nako nakong ea kalafo e eketsehileng, ho kgothaletsoa ho lekola boemo ba li-enzyme tsa sebete. Tabeng ea keketseho ea ts'ebetso ea li-transaminase ka makhetlo a fetang a 3 ha a bapisoa le VGN (moeli o kaholimo oa se tloaelehileng), Tsamaiso ea Tricor e lokela ho emisoa. Bakeng sa matšoao a hepatitis, liteko tse loketseng tsa laboratori li tlameha ho etsoa 'me, haeba tlhahlobo e netefalitsoe, tlohela lithethefatsi.

E 'ngoe ea litlamorao tsa fenofibrate ke nts'etsopele ea pancreatitis, lisosa tse ka hlahisoang ka kotloloho ho Tricor, ts'ebetso e sa lekanang ea lithethefatsi ho bakuli ba nang le hypertriglyceridemia e matla, litlamorao tsa sekhahla (ho silafala kapa ho ba teng ha majoe ho li-ducts tsa bile, ho baka tšitiso ea duct e tloaelehileng ea bile).

Keketseho ea rhabdomyolysis nakong ea kalafo ea lithethefatsi e eketseha ho bakuli ba nang le nalane ea ho se sebetse hantle ha renal kapa hypoalbuminemia. Ha matšoao a nang le litlamorao tse nang le chefo ho tishu ea mesifa (myositis, ferekanya myalgia, cramps, mesifa ea mesifa, keketseho ea litekanyetso tsa creatine phosphokinase ka makhetlo a fetang a 5 ha a bapisoa le VGN), kalafo ea fenofibrate e lokela ho emisoa.

Ts'ebetso e ts'oanang ea Tricor e nang le li-fiber tse ling kapa li-inhibitors tsa HMG-CoA tse eketsang menyetla ea litlamorao tse mpe ho mesifa, haholoholo haeba mokuli a se a ntse a e-na le mafu a mesifa pele ho kalafo. Ka lebaka lena, ts'ebeliso e kopaneng ea moriana o nang le li-statins e lumelloa feela maemong a thata a kopaneng a dyslipidemia le kotsi e eketsehang ea mathata a pelo le bakuli ba nang le nalane ea mafu a mesifa, hammoho le tlasa tlhokomelo e haufi e reretsoeng ho lemoha matšoao a ho senyeha ha mesifa.

Haeba nakong ea kalafo, mahloriso a "creatinine" a nyoloha ka ho feta 50% ho tloha VGN, tsamaiso ea Tricor e lokela ho emisoa. Boleng ba clearinine bo khothaletsoa ho shebeloa khafetsa nakong ea likhoeli tsa 3 tsa pele, hammoho le nako le nako nakong ea phekolo e eketsehileng.

Bokhachane le pelehi

Lintlha tse mabapi le tšebeliso ea lithethefatsi ho basali baimana ha lia lekana. Liteko tse entsoeng ho liphoofolo, ha ho litlamorao tse fumanoeng. Embryotoxicity e ile ea bonoa ka tšebeliso ea fenofibrate nakong ea liteko tsa tekanyetso ea litekanyetso tse nang le chefo 'meleng oa mosali. Ts'ebeliso ea Tricor nakong ea kemolo e ka etsahala feela kamora ho hlahloba tekanyo ea melemo ho mme / kotsi ho lesea.

Tlhahisoleseling mabapi le ho kenella ha fenofibrate kapa metabolites ea eona lebeseng la matsoele ha e lekane, ka hona ts'ebeliso ea lithethefatsi nakong ea lebone e tlotsitsoe.

Ho sebelisana le lithethefatsi

Tricor e lokela ho kopanngoa le temoso le lithethefatsi le lintho tse latelang:

• anticoagulants bakeng sa tsamaiso ea molomo: fenofibrate e ntlafatsa phello ea kalafo ea li-anticoagulants mme e ka eketsa kotsi ea ho tsoa mali (ho khothalletsoa ho fokotsa tekanyetso ea pele ea li-anticoagulants ka hoo e ka bang karolo ea boraro ebe ka mor'a moo butle-butle e eketsa),
• cyclosporine: ho senyeha ho matla hoa renal (ho khutlisetsoa morao) hoa khoneha, ka hona, ho bakuli ba joalo, ho hlokahala ho hlokomela boemo ba liphio,
• HMG-CoA reductase inhibitors (li-statins), li-fibrate tse ling: menyetla ea ts'enyo e mpe ea mesifa e chefo ea eketseha,
• thiazolidinedione derivatives (rosiglitazone, pioglitazone): ho fokotseha ho fokotsehang ha paramente ea mahlaseli a k'holeseterole ea HDL ho ka khoneha (ho kgothaletsoa ho lekola mahlakore a mangata a k'holeseterole ea HDL le ho hlakola fenofibrate ka phokotseho e kholo ea letšoao lena).

Litšoantšiso tsa Tricor ke Lipantil 200 M, Lipofen SR, Eclip, Trilipix, Lopid, Fenofibrat Canon, jj.

Tlhahlobo ea Traicore

Ho latela maikutlo, Tricor o sebetsana hantle le mosebetsi oa mantlha - o theola cholesterol le triglycerides. Nakong ea kalafo ka sethethefatsi, bakuli ba hlokometse tloaelehileng ea tsoekere ea mali le LDL le HDL, ba fokotsa bohloko maotong, ho theola boima ba 'mele. Leha ho le joalo, khafetsa melaong ea bona, basebelisi ba hlalosa litla-morao tsa ho fenofibrate, joalo ka ho nyekeloa pelo, bohloko ba ka mpeng le boima, bolutu, bofokoli bo akaretsang, bohloko ba mesifa, tšitiso ea maikutlo, ho se tsotelle le ho fokotseha ha khatello ea mali. Tlokotsi e 'ngoe ea lithethefatsi, bakuli ba nka litšenyehelo tsa eona tse phahameng.