Movoglen® (Movogleken)

Beha ka bomong ho latela setšoantšo sa lefu lena. Tekanyetso ea pele ea Movoglechen ke 2,5-5 mg 1 nako / letsatsi ka metsotso e 15-30 pele ho lijo tsa hoseng. Haeba ho hlokahala, lethalinyana le ka eketseha butle-butle (ka karohano e itseng) ka 2,5-5 mg / ka letsatsi. Litekanyetso tsa letsatsi le letsatsi tse fetang 15 mg li lokela ho aroloa ka litekanyetso tse peli.

Tekanyetso e kholo ea Movoglechen: single - 15 mg, letsatsi le letsatsi - 40 mg.

Ketso ea pharmacological

Moemeli oa hypoglycemic ea molomo, e fumanoang molokong oa bobeli. E hlohlelletsa secretion ea "insulin" ke "lisele" tsa manyeme, e eketsa ho tsoa ha insulin. Eketsa kutloisiso ea lisele tsa peripheral ho insulin. E na le hypolipidemic, fibrinolytic effect, inhibits kopanyo ea platelet.

Litlamorao

Ho tloha tsamaisong ea endocrine: ka seoelo - hypoglycemia (haholo-holo ho batho ba tsofetseng, bakuli ba fokolang, ba nang le ho ja ka tsela e sa tloaelehang, ho noa joala, ho senyeha ha sebete le ts'ebetso ea liphio).

Ho tsoa ho tsamaiso ea tšilo ea lijo: ho nyekeloa ke pelo, lets'ollo, le sa tloaelehang haholo - hepatitis e chefo.

Ho tsoa ho sistimi ea hemopoietic: maemong a mang - thrombocytopenia, leukopenia, agranulocytosis.

Boitšoaro bo kulang: ka seoelo - lekhopho la letlalo, ho hlohlona.

Litaelo tse khethehileng

Ha o sebelisa Movoglechen kamora insulin kapa li-agents tse ling tsa hypoglycemic, takatso e potlakileng ea Movoglechen maling e lokela ho nahaneloa mme matsatsing a 4-5 a pele lethal dose e lokela ho laoloa ho latela profil ea glycemic.

Ka nts'etsopele ea hypoglycemia, haeba mokuli a le teng, ho na le glucose (kapa tharollo ea tsoekere) kahare. Bakeng sa tahlehelo ea kelello, glucose e kenang kapa glucagon sc, intramuscularly kapa intravenous e tsamaisoa. Kamora ho hlaphoheloa kelellong, ho bohlokoa ho fa mokuli lijo tse nang le lik'habohaedreite e le ho qoba tsoelopele ea hypoglycemia.

Ka likotsi, tšoaetso e matla, ts'ebetso e kholo ea ts'ebetso ea ho buoa, mokuli o lokela ho fetisetsoa ts'ebelisong ea insulin.

Tšebelisano

Movoglechen ha ea lokela ho sebelisoa ka nako e le ngoe le miconazole.

Ka tšebeliso e le 'ngoe le li-salicylates, sulfonamides, li-inhibitors tsa ACE, tahi ea joala, ts'ebetso e matla ea hypoglycemic e ka hlaha. Ts'ebeliso e ts'oanang ea beta-blockers e ka pata lipontšo tsa hypoglycemia.

Liazine diuretics, li-progestin tsa maiketsetso, GCS (ho kenyelletsa ts'ebeliso ea mabitso), chlorpromazine e nyenyefatsa ketso ea Movoglechen.

Sehlopha sa mahlale

Tlohela maikutlo a hau

Lenaneo la Hona Joale la Litaba tsa Tlhokahalo, ‰

Setifikeiti tsa ho ngolisa tsa Movogleken ®

• LP-001191

Webosaete ea semmuso ea k'hamphani RLS ®. Encyclopedia ea mantlha ea lithethefatsi le thepa ea bongaka ea semmuso ea Marang-rang ea Russia. Lenane la lithethefatsi Rlsnet.ru le fa basebelisi monyetla oa ho fumana litaelo, litheko le litlhaloso tsa lithethefatsi, tlatsetso ea lijo, lisebelisoa tsa bongaka, lisebelisoa tsa bongaka le lihlahisoa tse ling. Tataiso ea meriana e kenyelletsa tlhahisoleseling mabapi le sebopeho le mofuta oa tokollo, ts'ebetso ea pharmacological, matšoao a ts'ebeliso, contraindication, litla-morao, tšebelisano ea lithethefatsi, mokhoa oa ts'ebeliso ea lithethefatsi, lik'hamphani tsa meriana. Sesebelisoa sa lithethefatsi se na le litheko tsa meriana le lihlahisoa tsa meriana ho la Moscow le metseng e meng ea Russia.

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Lintho tse ling tse ngata tse khahlang

Litokelo tsohle li sirelelitsoe.

Ts'ebeliso ea thepa ea khoebo ha e lumelloe.

Tlhahisoleseling ena e etselitsoe litsebi tsa bongaka.

Sebopeho Movoglechen ka sebopeho sa letlapa

Lintho tse sebetsang: glipizide - 5 mg,

Baeti: lactose 130 mg, pregelatinized starch 30 mg, microcrystalline cellulose 30 mg, hypromellose (hydroxypropyl methylcellulose) 0,8 mg, stearic acid 1.6 mg.

matlapa a chitja a chitja a 'mala o mosoeu a ngotsoe "U" mokokotlong ka lehlakoreng le leng le kotsi ka lehlakoreng le leng.

Pharmacodynamics ea lithethefatsi

Glipizide e na le litlamorao tsa pancreatic le extrapancreatic. E susumetsa secretion ea insulin ka ho fokotsa tsitsipano ea khatello ea "pancreatic beta-cell glucose", e eketsa kutloisiso ea insulin le ho tlamahanya le eona liseleng tse lebisitsoeng, e eketsa ho tsoa ha insulin, ho matlafatsa ts'ebetso ea insulin ho mesifa le mokokotlo oa "glucose", le ho thibela lipolysis ho lithane tsa adipose. Botebo ba phello ea hypoglycemic ho latela palo ea lisele tsa beta tse sebetsang. E boetse e na le hypolipidemic, fibrinolytic effect, inhibits kopanyo ea platelet, mme e na le phello e bonolo ea diuretic.

Mofumahali

Kamora ho tsamaisoa ka molomo, glipizide e potlaka ebile e batla e kenella ka botlalo ka mpeng ea mpa ea motho. Ts'ebetso e kholo ea plasma e fihlella lihora tse 1-3 kamora ho nka tekanyetso e le 'ngoe. Ho ja ha ho ame ho monya le ho bokella ha sethethefatsi leha ho le joalo, nako ea ho inkela e eketseha ka metsotso e 40. Bioavailability ke 90%, khokahano le liprotheine tsa plasma ke 98-99%.

E kenngoa ka har'a sebete ho metabolites e sa sebetseng. E epolloa ke liphio - 90% ka mokhoa oa metabolites, 10 % - ha e fetohe.

Bophelo ba halofo ke lihora tse 2-4.

Contraindication Movoglechen ka sebopeho sa letlapa

hypersensitivity sulfonylureas, sulfonamides,

hypersensitivity ho glipizide kapa motsoako ofe kapa ofe oa lithethefatsi,

mofuta oa 1 lefu la tsoekere

lefu la tsoekere la ketoacidosis, lefu la tsoekere le leta,

maemo a hlokang kalafo ea insulin (ho chesoa ho hoholo, ho kenella ha ts'ebetso e kholo, likotsi tse mpe le mafu a tšoaetsanoang),

ho se sebetse hantle ha sebete le liphio,

khaello ea lactase, ho se mamelle lactose, malabsorption ea glucose-galactose,

ho ima, ho nyeka.

Tekanyetso le tsamaiso ea Movoglechen ka sebopeho sa tafole

Tekanyetso e itšetlehile ka lilemo, botebo ba lefu la tsoekere, khatello ea tsoekere maling maling ka mpeng e se nang letho le lihora tse peli kamora ho ja.

Abela ka hare, metsotso e 30 pele ho lijo. Tekanyetso ea pele ea letsatsi le letsatsi ke 5 mg pele ho lijo tsa hoseng, haeba ho se na phello, lethal dose le eketseha ka 2,5-5 mg ka ho beha leihlo nako le nako ea khatello ea mali maling.

Ho mafu a sebete, liphio le bakuli ba tsofetseng, tekanyetso ea pele ea letsatsi le letsatsi ke 2,5 mg.

Tekanyo e phahameng e le 'ngoe ke 15 mg, palo e phahameng ea letsatsi le letsatsi ke 40 mg. Khafetsa ea tsamaiso ke nako e le 'ngoe ka letsatsi, tekanyetso ea letsatsi le letsatsi e fetang 15 mg e lokela ho aroloa ka tekanyetso ea 2-4.

Litla-morao tsa meriana

Ho tsoa tsamaisong ea endocrine: hypoglycemia, hypoglycemic coma.

Ho tsoa tsamaisong ea methapo: ho tsekela, ho opeloa ke hlooho, ho otsela.

Ka lehlakoreng la letlalo: lekhopho letlalong le mucous ea hau, ho hlohlona ha letlalo, urticaria, eczema, photosensitivity.

Ho tsoa lithong tsa hemopoietic: inhibition of marrow hematopoiesis (phokolo ea mali, ho kenyelletsa aplastic le hemolytic, pancytopenia, leukopenia, agranulocytosis, thrombocytopenia).

Ho tsoa ts'ebetsong ea tšilo ea lijo: ho nyekeloa ke pelo, ho hlatsa, lets'ollo kapa ho sokela, ho ruruha, cholestatic jaundice, ho hloleha ha sebete, hepatitis, porphyria e hlobaetsang.

Ho tsoa lithong tsa kutlo: pono e fifalitsoeng ea pono, pono e sa boneng.

Matšoao a Laborator: ts'ebetso e eketsehileng ea "aspartate aminotransferase" (ACT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), eketseha ka naetrojene ea urea naetrojene ho plasma ea mali, hypercreatininemia.

Tse ling: boima ba mmele, myalgia, tsitsipano, hyponatremia, disulfiram-like reaction.

Ho tsoa pampiring ea ka mpeng: ho nyekeloa ke pelo, ho hlatsa, ho sokela, lets'ollo, bohloko ba ho bola, lefu la sebete.

Ka lehlakoreng la letlalo: urasharia makhopho, ho hlohlona letlalo, erythema multiforme exudative.

Ho tsoa lithong tsa hemopoietic: anemia, aplastic le hemolytic anemia, pancytopenia, leukopenia, agranulocytosis, eosinophilia, thrombocytopenia.

Tse ling: Mohlomong nts'etsopele ea hyponatremia le secretion e senyehileng ea li-hormone tsa antidiuretic.

Bongata

Ho sebelisa moriana o feteletseng oa lithethefatsi ho ka lebisa ho kholo ea hypoglycemia.

Matšoao a hypoglycemia: tlala, ho fufuleloa ho eketsehileng, bofokoli bo matla, ho thothomela ho hoholo, ho tšoenyeha, ho opeloa ke hlooho, ho hloka boroko, ho teneha, khatello ea maikutlo, puo e sa bonahaleng le pono, bothata ba ho tsepamisa mohopolo, ho hloka kelello, ho akheha hoa kelello.

Phekolo: Haeba mokuli a hlokahalletse, nka tsoekere kapa tsoekere ka hare, haeba ho ka etsahala hore a lahleheloe ke kelello, ho hlokahala hore ho laoloe tšebetso ea methapo e 40 % Tharollo ea dextrose (glucose), joale - infusion ea tharollo ea 5% ea dextrose, 1-2 mg ea glucagon ka tsela e ikhethileng, ka methapo kapa kahare. Kamora ho hlaphoheloa kelellong, ho bohlokoa ho fa mokuli lijo tse nang le lik'habohaedreite tse bonolo tse tsoang habonolo (molemong oa ho qoba tsoelopele ea hypoglycemia). Ka lefu la mokokotlo la mokokotlo, mannitol le dexamethasone.

Fomu ea ho lokolla, ho paka le ho hlophisoa

Matlapa a cylindrical a pota-potileng a nang le "U" moqikeng o ka lehlakoreng le leng le kotsi ka lehlakoreng le leng.

Bahlomphehi: lactose 130 mg, pregelatinized starch 30 mg, microcrystalline cellulose 30 mg, hypromellose (hydroxypropyl methylcellulose) 0,8 mg, stearic acid 1.6 mg.

Li-PC tse 24. - lithutsoana tse entsoeng ka PVC / aluminium foil (2) - lipakete tsa karete.

Melemo ea litekanyetso

Beha ka bomong ho latela setšoantšo sa lefu lena. Motsoako oa pele ke 2,5-5 mg 1 nako / letsatsi ka metsotso e 15-30 pele ho lijo tsa hoseng. Haeba ho hlokahala, lethalinyana le ka eketseha butle-butle (ka karohano e itseng) ka 2,5-5 mg / ka letsatsi. Litekanyetso tsa letsatsi le letsatsi tse fetang 15 mg li lokela ho aroloa ka litekanyetso tse peli.

Boleiti bo boholo: single - 15 mg, letsatsi le letsatsi - 40 mg.

Litla-morao

Ho tloha tsamaisong ea endocrine: ka seoelo - hypoglycemia (haholo-holo ho batho ba tsofetseng, bakuli ba fokolang, ba nang le ho ja ka tsela e sa tloaelehang, ho noa joala, ho senyeha ha sebete le ts'ebetso ea liphio).

Ho tsoa ho tsamaiso ea tšilo ea lijo: ho nyekeloa ke pelo, lets'ollo, le sa tloaelehang haholo - hepatitis e chefo.

Ho tsoa ho sistimi ea hemopoietic: maemong a mang - thrombocytopenia, leukopenia, agranulocytosis.

Boitšoaro bo kulang: ka seoelo - lekhopho la letlalo, ho hlohlona.

Tse ling: hlooho ea hlooho.

Ho sebelisana le lithethefatsi

Ka tšebeliso e le 'ngoe le li-salicylates, sulfonamides, li-inhibitors tsa ACE, tahi ea joala, ts'ebetso e matla ea hypoglycemic e ka hlaha. Ts'ebeliso e ts'oanang ea beta-blockers e ka pata lipontšo tsa hypoglycemia.

Liazide diuretics, li-progestin tsa maiketsetso, GCS (ho kenyelletsa ts'ebeliso ea li-topical), chlorpromazine e fokolisa phello ea glipizide.

Lithethefatsi tse tšoanang:

• Guarem (Guarem) E entsoe ka li-Microbeads
• Matlapa a Amaryl
• Tharollo ea Viktoza (Victoza) bakeng sa ente
• Metformin hydrochloride (Metformin hydrochlor> Substance-Powder
• Matlapa a molomo a Metformin-Teva (Metformin-Teva)
• Matlapa a molomo oa Galvus Met (Galvus Met)
• Letlapa la molomo la Januvia
• Matlapa a molomo oa Berlithion (Berlithion)
• Matlapa a molomo oa Glucovans (Glucovance)
• Matlapa a molomo oa Langerin (Lanagerin)

** Tataiso ea ho fana ka litlhare ke bakeng sa tlhahisoleseling. Bakeng sa tlhaiso-leseling e batsi, ka kopo sheba litlhaloso tsa moetsi. Se ke oa inahanela, pele u qala ts'ebeliso ea lithethefatsi Movogleken o lokela ho etela ngaka. EUROLAB ha e ikarabelle bakeng sa litlamorao tse bakoang ke ts'ebeliso ea tlhaiso-leseling e hatisitsoeng portal. Tlhahiso-leseling efe kapa efe e teng sebakeng sa marang-rang ha e nke sebaka sa keletso ea ngaka ebile e ke ke ea fana ka tiiso ea litlamorao tsa lithethefatsi.

O na le thahasello ho Movoglecen? Na u batla ho tseba lintlha tse qaqileng kapa u hloka ho bona ngaka? Kapa o hloka tlhahlobo? O ka khona etsa tumellano le ngaka - Euro tleliniki lab kamehla ts'ebetsong ea hau! Lingaka tse ntle li tla u hlahloba, ho u eletsa, ho fana ka thuso e hlokahalang le ho etsa tlhahlobo ea mafu. U ka khona letsetsa ngaka lapeng. Clinic Euro lab e buletsoe nako eohle.

** Hlokomela! Tlhahisoleseling e hlahisitsoeng tataisong ena ea meriana e etselitsoe litsebi tsa bongaka 'me ha ea lokela ho ba mabaka a ho itlhalosa. Tlhaloso ea lithethefatsi Movoglecen e fanoa bakeng sa tlhaiso-leseling ebile ha e reretsoe ho khethoa kalafo ntle le ho nka karolo ha ngaka. Bakuli ba hloka boeletsi bo ikhethang!

Haeba u khahloa ke meriana le litlhare tse ling, litlhaloso tsa bona le litaelo tsa tšebeliso, tlhaiso-leseling mabapi le sebopeho le mofuta oa tokollo, matšoao a ts'ebeliso le litlamorao, mekhoa ea ts'ebeliso, litheko le litlhahlobo tsa meriana, kapa na u na le lipotso tse ling le litlhahiso - re ngolle, ka sebele re tla leka ho u thusa.

Ts'ebeliso ea Movoglechen nakong ea kemolo le ho fepa

Mokhahlelo oa FDA bakeng sa lesea le sa tsoa emoloa ke C.

Maemong a ts'ebeliso nakong ea kemaro, ho hlakola ho tlameha khoeli pele ho tsoalo e lebelletsoeng le phetoho ea kalafo ea insulin.

Ka nako ea kalafo o lokela ho emisa ho anyesa.

Phekolo: Ho tlosoa hoa lithethefatsi, ho ja lijo tse ngata tsa tsoekere le / kapa phetoho ea lijo ka tlhahlobo ea "glycemia" e nang le ts'oaetso e matla ea khatello ea kelello - ho kenella sepetlele hang-hang, ts'ebetso ea tharollo ea glucose ea 50% ka tlhahiso e ts'oanang ea nako e tšoanang (iv drip) 10 % tharollo ea tsoekere ho netefatsa hore khatello ea tsoekere ea mali e kaholimo ho 5.5 mmol / L, tlhaiso ea glycemia e ea hlokahala matsatsing a 1-2 kamora hore mokuli a tlohele ho akheha. Ho buoa ka meno ha ho na thuso.

Liminerale le glucocorticoids, amphetamines, anticonvulsants (li-hydantoin derivatives), li-solaraginase, baclofen, calcium antagonists, carbonic anhydrase inhibitors (acetazolamide), chlortalidone, lithibela-pelehi tsa molomo, epinephrine, ethacinic acid, giurimide, thymoside litšoelesa, triamteren le lithethefatsi tse ling tse bakang hyperglycemia. Li-anabolic tsa li-androgen le li-androgens li ntlafatsa ts'ebetso ea hypoglycemic. Li-anticoagulants tse sa tobang, li-NSAID, chloramphenicol, clofibrate, guanethidine, li-inhibitors tsa MAO, probenecid, sulfonamides, rifampicin e eketsa karolo ea karolo e sa lefelloeng maling (ka lebaka la phallo ho liprotheine tsa plasma) le ho potlakisa biotransformation. Ketonazole, miconazole, sulfinpyrazone block inactivation le ho eketsa hypoglycemia. Khahlano le semelo sa joala, ho nts'etsopele ea discriram-syndrome (bohloko ba ka mpeng, ho nyekeloa ke pelo, ho hlatsa, hlooho) hoa khoneha. Lithethefatsi tsa Antithyroid le myelotoxic li eketsa menyetla ea ho theha agranulocytosis, ea bobeli, ho ekelletsa moo - thrombocytopenia.

Bakeng sa sebopeho sa glipizide se liehang ho nka bohato:

Ho tsoa ho tsamaiso ea methapo ea kutlo le litho tsa methapo ea kutlo: ho tsekela, ho opeloa ke hlooho, ho hlobaela, ho otsela, ho tšoenyeha, khatello ea maikutlo, pherekano, ho khathatseha ka moea o mongata, ho senyeha ha pelo, lesira ka pel'a mahlo, bohloko ba mahlo, conjunctivitis, hemorrhage ea morao.

Ho tloha lehlakoreng la tsamaiso ea methapo ea pelo le mali (hematopoiesis, hemostasis): syncope, arrhythmia, hypertension ea methapo, maikutlo a ho thulana ha mocheso.

Ho tloha ka lehlakoreng la metabolism: hypoglycemia.

Ho tloha tšilo ea lijo: ho ipolaisa tlala, ho nyekeloa ke pelo, ho hlatsa, maikutlo a ho imoloha sebakeng sa epigastric, dyspepsia, ho sokela, motsoako oa mali setulong.

Ho tloha letlalong: lekhopho, uritisaria, ho hlohlona.

Ho tsoa ts'ebetsong ea phefumoloho: rhinitis, pharyngitis, dyspnea.

Ho tsoa ho tsamaiso ea genitourinary: dysuria, e fokotsehile libido.

Tse ling: lenyora, ho thothomela, edema ea potoloho, bohloko bo sa reroang ho pholletsa le 'mele, arthralgia, myalgia, cramps, sweatshi.

Bakeng sa sebopeho se sebetsang ka potlako sa glipizide:

Ho tsoa tsamaisong ea methapo ea kutlo le litho tsa kutlo: hlooho ea hlooho, ho tsekela, ho otsela.

Ho tsoa ho tsamaiso ea methapo ea pelo le mali (hematopoiesis, hemostasis: leukopenia, agranulocytosis, thrombocytopenia, pancytopenia, hemolytic kapa anemia ea aplasiki.

Ho tloha lehlakoreng la metabolism: lefu la tsoekere insipidus, hyponatremia, lefu la porphyrin.

Ho tsoa ho tšilo ea lijo: ho nyekeloa ke pelo, ho hlatsa, bohloko bo sebakeng sa epigastric, ho sokela, cholestatic hepatitis (letheba le letlalo le sclera, discoloration ea setofo le ho fifala ha moroto, bohloko ho hypochondrium e nepahetseng).

Ho tloha letlalong: erythema, li-maculopapular rashes, urticaria, photosensitivity.

Tse ling: Litekanyetso tse eketsehileng tsa LDH, alkaline phosphatase, bilirubin e sa tobang.

Mathata a amanang le tšilo ea lijo, sebete le liphio (a hloka ho lekola khafetsa maemo a tsoekere ea mali), lilemo tsa bana (katleho le polokeho ea tšebeliso ho bana ha li e-so thehoe).

Hypersensitivity, lefu la tsoekere ketoacidosis, lefu la tsoekere, mofuta oa mocha 1 lefu la tsoekere, feberu, likotsi, ts'ebetso ea ho buuoa, boimana, ho anyesa.

Type 2 lefu la tsoekere ha ho na phello ea lijo tse nang le khalori e fokolang, ho ikoetlisa ka ho lekaneng, joalo-joalo, lefu la tsoekere la diabetes.

Phello ea pharmacological ke hypoglycemic. E susumetsa ho lokolloa ha insulin ho tsoa liseleng tse sebetsang tsa pancreatic beta. E fokotsa boemo ba hemoglobin ea glycosylated le ho pepeseha ha glucose ho bakuli ba nang le mefuta e leka-lekaneng le e matla ea lefu la tsoekere le sa hlokeng insulin. E fokotsa hyperglycemia ea ka mor'a lijo, e eketsa mamello ea tsoekere le ho hlakisoa ha mokelikeli oa mahala (ho isa tekanyong e nyane). Karabelo ea insulinotropic e ba teng ka nako ea metsotso e 30 kamora ho tsamaisoa ka molomo, nako ea ts'ebetso ka tekanyetso e le 'ngoe e fihla lihora tse 24. Ha e ame boemo ba lipidma ba mali a mali.

Litekong tsa likhoto le litoeba ho makhetlo a 75 ho feta MPD, ha e khothalletse carcinogeneis hape ha e ame tsoalo (likhoto). Boithuto bo entsoeng ho libaktheria le vivo ha boa ka ba senola thepa ea mutagenic.

Foromo e sebetsang ka potlako e ananeloa kapele le ka botlalo. Ho ja ha ho ame ho amoheloa ka botlalo, empa ho fokotsa lebelo ka metsotso e 40. Cmax e tsebahala ka mor'a lihora tse 1-3 ka mor'a tekanyetso e le 'ngoe. T1 / 2 ke lihora tse 2 - 4. Kamora ho nka sebopeho se sebetsang butle, le hlaha maling kamora lihora tse 2-3, Cmax e fihlelloa kamora lihora tse 6 ho isa ho tse 6. E lumellana le liprotheine tsa plasma tsa mali ka 98-99%. Bophahamo ba modumo ka mora ho tsamaisoa ha iv ke 11 l, karolelano ea T1 / 2 ke lihora tse 2-5. Kakaretso ea Cl kamora tsamaiso e le 'ngoe ea iv e 3 l / h. Biotransformed ka har'a sebete (ka karolo ea pele - hanyane). Karolo e ka tlase ho 10% ha e sa fetoloe ka har'a moroto le makhopho, hoo e ka bang 90% e hloekisoa ka sebopeho sa metabolites ka moroto (80%) le makhopho (10%).

Phofo e tšoeu e se nang mafura. Ha e kenelle ka metsing le joala, empa e qhibilihile ka tharollo ea 0,1 mol / L NaOH ebile e qhibilihile haholo ho dimethylformamide.

N-2-4- (Cyclohexylamino) carbonylamino sulfonylphenylethyl-5-methylpyrazine carboxamide