Litaelo tsa Metfogamma 1000 bakeng sa ts'ebeliso, contraindication, litla-morao, litlhahlobo

Lebitso la machabeng:Metfogamm 1000

Sebopeho le mofuta oa tokollo

Matlapa, a koahetsoeng ka koae e tšoeu ea filimi, a pepetehile, a na le kotsi, a se na monko. Letlapa le le leng le na le 1000 mg ea meformin hydrochloride. Bahlomphehi: hypromellose (15000 CPS) - 35.2 mg, povidone (K25) - 53 mg, magnesium stearate - 5.8 mg.

Sebopeho sa Shell: hypromellose (5 CPS) - 11.5 mg, macrogol 6000 - 2.3 mg, titanium dioxide - 9.2 mg.

Ho marang-rang matlapa a 30 kapa a 120. E kentsoe ka lebokoseng la karete.

Sehlopha sa tliliniki le meriana

Setlhare sa molomo sa hypoglycemic

Sehlopha sa Pharmacotherapeutic

Hypoglycemic agent bakeng sa tsamaiso ea molomo ea sehlopha sa Biguanide

Ts'ebetso ea pharmacological ea lithethefatsi Metfogamma 1000

Setlhare sa molomo sa hypoglycemic se tsoang sehlopheng sa Biguanide E thibela gluconeogenesis ka har'a sebete, e fokotsa ho monya ha tsoekere ka mpeng, e ntlafatsa ts'ebeliso ea tsoekere, hape e eketsa le kutloisiso ea lisele tsa mmele ho insulin. Ha e ame secretion ea insulin ke lisele tsa β-pancreas.

Lowers triglycerides, LDL.

E tsitsisa kapa e theola boima ba 'mele.

E na le phello ea fibrinolytic ka lebaka la khatello ea inhibitor ea tisy ea plasminogen activator.

Mofumahali

Kamora ho tsamaisoa ka molomo, metformin e nkuoa ho tsoa mokokotlong oa lijo. Bioavailability kamora ho nka tekanyetso e tloaelehileng ke 50-60%. C max kamora hore tsamaiso ea molomo e fihlelisoe kamora lihora tse peli

Ha e lumellane le liprotheine tsa plasma. E bokellana ka har'a litšoelesa tse qhekellang, mesifa, sebete le liphio.

E tšolotsoe e sa fetoha moroto. T 1/2 ke lihora tse 1.5-4,5.

Pharmacokinetics maemong a khethehileng a kliniki

Ka ts'ebetso ea renal e sa sebetseng hantle, ho sebelisoa hoa lithethefatsi hoa khoneha.

Mofuta oa 2 lefu la tsoekere mellitus (e sa itšetleheng ka insulin) ntle le tloaelo ea ketoacidosis (haholoholo ho bakuli ba nang le botenya) ka kalafo ea phepo e sa sebetseng.

Contraindication

Hypersensitivity, hyperglycemic coma, ketoacidosis, lefu le sa foleng la 'mele, lefu la sebete, ho nyekeloa ke pelo, mafutsana a matla a pelo, ho se khone ho hema, ho felloa ke metsi, mafu a tšoaetsanoang, ts'ebetso e kholo le likotsi, joala, lijo tse nang le khalori e tlase (ka tlase ho 1000 kcal / ka letsatsi), lactic acidosis (ho kenyelletsa le lactic acidosis (ho kenyelletsa le lactic acidosis) nalane), boimana, ho nyekeloa. Setlhare ha se laetsoe matsatsi a 2 pele ho ts'ebetso ea bongaka, radioisotope, lithuto tsa x-ray ka ho hlahisoa ha lithethefatsi tse fapaneng le matsatsing a 2 kamora ts'ebetso ea ona. Ho feta lilemo tse 60, ho etsa mosebetsi o boima oa 'mele (kotsi e eketsehang ea ho ba le lactic acidosis ho bona).

Mokhoa oa litekanyetso le mokhoa oa ts'ebeliso Metfogamm 1000

Beha ka bomong, o ela hloko boemo ba glucose maling.

Motsoako oa pele hangata ke 500 mg-1000 mg (1 / 2-1 tab.) / Letsatsi. Keketseho e ntseng e eketseha butle-butle ea tekanyetso e ka khonahala ho latela phello ea kalafo.

Motsoako oa tlhokomelo ke 1-2 g (matlapa a 1-2) / ka letsatsi. Sekhahla se phahameng sa letsatsi ke 3 g (matlapa a 3). Morero oa sethethefatsi ka tekanyetso e phahameng ha se eketse phello ea pheko.

Matlapa a lokela ho nooa le lijo ka kakaretso, a hlatsoe ka metsi a fokolang (khalase ea metsi).

Setlhare sena se reretsoe tšebeliso ea nako e telele.

Ka lebaka la kotsi e eketsehang ea lactic acidosis, mathateng a tebileng a metabolic, lethal dose e lokela ho fokotsoa.

Litlamorao

Ho tsoa ts'ebetsong ea tšilo ea lijo: ho nyekeloa, ho hlatsa, bohloko ba ka mpeng, lets'ollo, ho hloka takatso ea lijo, tatso ea tšepe molomong (e le molao, ho khaotsa kalafo ha ho hlokehe, 'me matšoao a nyamela ka bo bona ntle le ho fetola tekanyetso ea lithethefatsi, khafetsa le ho teba ha litlamorao ho ka fokotsoa ka keketseho ea butle-butle ea lethal dose ea metformin), ka seoelo - phallo ea methapo ea liteko tsa sebete, hepatitis (feta kamora ho tlosoa hoa lithethefatsi).

Litla-morao: lekhopho la letlalo.

Ho tsoa tsamaisong ea endocrine: hypoglycemia (ha e sebelisoa ka tekanyetso e sa lokelang).

Ka lehlakoreng la metabolism: ka seoelo - lactic acidosis (e hloka pheko ea kalafo), ka tšebeliso ea nako e telele - hypovitaminosis B₁₂ (malabsorption).

Ho tsoa ho sheropoietic system: maemong a mang - anemia ea megaloblastic.

Bokhachane le pelehi

Setlhare sena se kopantsoe hore se sebelisoe nakong ea bokhachane le ho lactation (sefuba) .Seketso sa ts'ebetso ea ho senyeha ha sebete. Setlhare se emisitsoe bakeng sa ts'ebeliso ea ts'ebetso ea ho senyeha ha sebete.

Sebelisa ho bakuli ba tsofetseng

Ha ho khothalletsoe ho sebelisa lithethefatsi ho bakuli ba lilemo tse ka holimo ho 60 ba etsang mosebetsi o boima oa 'mele, ka lebaka la kotsi e eketsehang ea lactic acidosis.

Litaelo tse khethehileng tsa ho amoheloa Metfogamm 1000

Nakong ea kalafo, ho hlokahala hore ho sebetsanoe le ts'ebetso ea renal; boikemisetso ba plasma lactate bo lokela ho etsoa bonyane makhetlo a 2 ka selemo, hammoho le ponahalo ea myalgia. Ka nts'etsopele ea lactic acidosis, ho khaotsa kalafo hoa hlokahala. Ho khethoa ha ho khothalletsoe tšoaetso e matla, likotsi le kotsi ea ho omella. Ka kalafo e kopaneng le tse tlisoang ke sulfonylurea, ho hlokahala hore ho etsoe hloko ka hloko tsoekere ea mali. Tšebeliso e kopaneng le insulin e khothalletsoa sepetlele.

Bongata

Matšoao lefu la lactic acidosis le ka hlaha. Sesosa sa nts'etsopele ea lactic acidosis le eona e ka ba ho lutla ha moriana ka lebaka la ts'ebetso ea renal e sa sebetseng. Matšoao a pele a lactic acidosis ke ho nyekeloa pelo, ho hlatsa, lets'ollo, ho fokotsa mocheso oa 'mele, bohloko ba ka mpeng, bohloko ba mesifa, bokamosong ho khona ho eketsa ho hema, ho tsekela, ho akheha ho tseba hantle le ho holofala ha komello.

Phekolo: haeba ho na le matšoao a lactic acidosis, kalafo e nang le Metfogamma 1000 e lokela ho emisoa hang-hang, mokuli o lokela ho kena sepetlele ka potlako mme ha a se a lemohile hore o na le lactate, netefatsa hore o tšoeroe ke lefu leo. Hemodialysis e sebetsa hantle haholo bakeng sa ho tlosa lactate le metformin 'meleng. Haeba ho hlokahala, etsa kalafo e nang le matšoao.

Ka kalafo e kopaneng le sulfonylureas, hypoglycemia e ka hlaha.

Tšebelisano le Meriana e meng

Ka tšebeliso e tšoanang ea nifedipine e eketsa ho amoheloa ha metformin, C_maxe liehisa ho tebela.

Lithethefatsi tsa cationic (amlodipine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, vancomycin) tse fumanehang ka har'a marang-rang li qothisana le litsamaiso tsa tsamaiso ea methapo, mme ka kalafo ea nako e telele, li ka eketsa C_max 60% metformin.

Ka ts'ebeliso e le 'ngoe le sulfonylurea derivatives, acarbose, insulin, NSAIDs, li-inhibitors tsa MAO, oxetetracycline, li-inhibitors tsa ACE, li-derifatives tse tsoang ka har'a marang-rang, cyclophosphamide le beta-blockers, ho khonahala ho eketsa phello ea hypoglycemic ea metformin.

Ka ts'ebeliso e le 'ngoe le GCS, lithibela-pelehi tsa molomo, epinephrine (adrenaline), sympathomimetics, glucagon, lihomone tsa qoqotho, thiazide le loopback diuretics, li-phenothiazine derivatives le nicotinic acid, ho fokotseha hoa phello ea hypoglycemic ea metformin ho ka etsahala.

Cimetidine e liehisa ho felisoa ha metformin, ka lebaka leo kotsi ea lactic acidosis e eketsehang.

Metformin e ka fokolisa phello ea li-anticoagulants (tse tsoang ho coumarin).

Ka tsamaiso e ts'oanang ka ethanol, nts'etsopele ea lactic acidosis e khonahala.

Lipehelo tsa Maemo a Phomolo ea meriana

Setlhare ke ngaka.

Lipehelo le maemo a polokelo Metfogamm 1000

Moriana o lokela ho bolokoa o le hole le bana ka mocheso o sa feteng 25 ° C. Bophelo ba Shelf ke lilemo tse 4.

Ts'ebeliso ea lithethefatsi Metfogamm 1000 feela joalo ka ha u laetsoe ke ngaka, tlhaloso e fanoa bakeng sa ho buuoa!

Mokhoa oa ho lokolla Metfogamma 1000, sephutheloana sa lithethefatsi le sebopeho.

Matlapa a koahetsoeng
1 tab
metformin hydrochloride
1 g

Baeti: hypromellose (15,000 CPS), magnesium stearate, povidone (K25).

Sebopeho sa Shell: hypromellose (5CPS), macrogol 6000, titanium dioxide.

Li-pcs tse 10 - lithutsoana (3) - lipakete tsa karete.
Li-pcs tse 10 - lithutsoana (12) - lipakete tsa karete.
Li-pcs tse 15. - Mabokose (2) - lipakete tsa karete.
Li-pcs tse 15. - marangrang (8) - lipakete tsa karete.

TLHOKOMELISO EA TLHALOSO EA SEBETSO.
Tlhahisoleseling eohle e fanoeng e hlahisoa feela bakeng sa ho tloaelana le moriana, o lokela ho buisana le ngaka ka monyetla oa ho e sebelisa.

Ts'ebetso ea pharmacological Metfogamm 1000

Oral hypoglycemic agent e tsoang sehlopheng sa Biguanides (dimethylbiguanide). Mochine oa ts'ebetso oa metformin o amahanngoa le bokhoni ba eona ba ho hatella gluconeogenesis, hammoho le ho thehoa ha mafura a mahala le oxidation ea mafura. Metformin ha e ame palo ea insulin maling, empa e fetola li-pharmacodynamics tsa eona ka ho fokotsa karolelano ea insulin ho lokolla le ho eketsa tekanyo ea insulin ho proinsulin. Khokahano ea bohlokoa mochineng oa tšebetso ea metformin ke ho hlohlona ha tsoekere ea glucose ke lisele tsa mesifa.

Metformin e ntlafatsa phallo ea mali ka har'a sebete 'me e potlakisa phetoho ea tsoekere ho glycogen. Fokotsa boemo ba triglycerides, LDL, VLDL. Metformin e ntlafatsa likarolo tsa mali tsa fibrinolytic ka ho hatella inhibitor ea mofuta oa lisele tsa mofuta oa plasminogen.

Pharmacokinetics ea lithethefatsi.

Metformin e nkuoa ho tsoa mohopolong oa tšilo ea lijo. Cmax ho plasma e fihlella lihora tse ka bang peli kamora ho kenella. Kamora lihora tse 6, ho amoheloa ho tsoang ka mpeng ea gastrointestinal ho fela mme khatello ea metformin ka plasma butle-butle e ea fokotseha.

Ha e lumellane le liprotheine tsa plasma. E bokellana ka har'a litsoelesa tse tsoang ka mothong, sebete le liphio.

T1 / 2 - lihora tse 1.5-4.5. E supiloe ke liphio.

Tabeng ea ts'ebetso ea renal e sa sebetseng hantle, ho fumaneha ha metformin hoa khoneha.

Tekanyetso le tsela ea tsamaiso ea moriana.

Bakeng sa bakuli ba sa fumanang insulin, matsatsing a 3 a pele - 500 mg makhetlo a 3 / ka letsatsi kapa 1 g makhetlo a 2 / letsatsi nakong kapa ka mor'a lijo. Ho tloha matsatsing a 4 ho isa ho la 14 - 1 g makhetlo a 3 / letsatsi. Kamora letsatsi la leshome le metso e mehlano, tekanyetso e ea fetoloa ho nahanisisa boemo ba tsoekere maling le moriring. Motsoako oa tlhokomelo ke 100-200 mg / ka letsatsi.

Ka tšebeliso e tšoanang ea "insulin" ka tekanyo ea li-unit tse ka tlase ho 40 / ka letsatsi, moriana oa litekanyetso tsa metformin o ts'oana, ha tekanyetso ea insulin e ka fokotsoa butle-butle (ka likarolo tsa 4-8 / letsatsi ka letsatsi le leng le le leng). Haeba mokuli a amohela li-unit tse fetang 40 ka letsatsi, ts'ebeliso ea metformin le phokotso ea tekanyetso ea insulin li hloka tlhokomelo e kholo mme li etsoa sepetlele.

Side effect Metphogamm 1000:

Ho tsoa ho tsamaiso ea tšilo ea lijo: ho khoneha (hangata qalong ea kalafo) ho nyekeloa, ho hlatsa, lets'ollo.

Ho tsoa tsamaisong ea endocrine: hypoglycemia (haholo ha e sebelisoa ka tekanyetso e sa lekanang).

Ho tloha lehlakoreng la metabolism: maemong a mang - lactic acidosis (e hloka ho khaotsa kalafo).

Ho tsoa ho sistimi ea hemopoietic: maemong a mang - anemia ea megaloblastic.

Khokahano ea lithethefatsi:

Khaolo e matla ea sebete le liphio, pelo le ho hloleha ho phefumoloha, karolo e mpe ea lefu la myocardial, ho lemalla joala bo sa foleng, lefu la tsoekere, ketoacidosis, lactic acidosis (ho kenyeletsa nalane), lefu la tsoekere la lefu la tsoekere, ho ima, ho lactation, hypersensitivity ho metformin.

TLHOKOMELISO LE KHUTLISO
E kopantsoe le ho ima le ho nyeka.

Litaelo tse khethehileng bakeng sa ts'ebeliso ea Metfogamma 1000.

Ha e khothalletsoe tšoaetso e matla, ho mpefatsa ha mafu a tšoaetsanoang a sa foleng le ho ruruha, likotsi, maloetse a opang ka matla le kotsi ea ho omella.

Se ke oa sebelisa pele u buuoa le pele ho feta matsatsi a mabeli kamora hore a buuoe.

Ha ho kgothaletswe ho sebelisa metformin ho bakuli ba lilemo tse fetang 60 le ba sebetsang ka thata, ba amanang le kotsi ea ho ba le lactic acidosis.

Nakong ea phekolo, ho hlokahala hore ho hlahlojoe ts'ebetso ea renal, boikemisetso ba dikahare tsa lactate ho plasma bo lokela ho etsoa bonyane makhetlo a 2 ka selemo, hammoho le ponahalo ea myalgia.

Metformin e kanna ea sebelisoa hammoho le sulfonylureas. Maemong ana, ho hlokahala haholo ho lekola maemo a tsoekere ea mali.

Tšebeliso ea metformin e le karolo ea kalafo e kopaneng le insulin e khothalletsoa sepetlele.

Tšebelisano ea Metfogamm 1000 le lithethefatsi tse ling.

Ka tšebeliso e ts'oanang le li-derivatives tsa sulfonylurea, acarbose, insulin, salicylates, li-inhibitors tsa MAO, oxytetracycline, li-inhibitors tsa ACE, tse nang le clofibrate, cyclophosphamide, phello ea hypoglycemic ea metformin e ka ntlafatsoa.

Ka tšebeliso e le 'ngoe le GCS, lithibela-pelehi tsa li-hormone bakeng sa tsamaiso ea molomo, adrenaline, glucagon, lihormone tsa qoqotho, litlamorao tsa phenothiazine, li-thiazide diuretics, li-nicotinic acid derivatives, ho fokotseha hoa phello ea hypoglycemic ea metformin ho ka etsahala.

Tšebeliso e tšoanang ea cimetidine e ka eketsa kotsi ea lactic acidosis.

Litšoantšo tsa 3D

Mofumahali

E thibela gluconeogeneis ka har'a sebete, e fokotsa ho monya ha tsoekere ka mpeng, e ntlafatsa ts'ebeliso ea tsoekere, 'me e phahamisa kutloisiso ea lisele tsa mmele ho insulin. Fokotsa boemo ba triglycerides le lipoprotein tse tlaase maling. E na le phello ea fibrinolytic (e thibela ts'ebetso ea mofuta oa li-inhibitor tsa mofuta oa lisele), e tsitsisa kapa e theola boima ba 'mele.

Litlamorao

Ho tsoa ho tsamaiso ea pelo le mali (hematopoiesis, heestasis): maemong a mang me anemblastic anemia.

Ho tsoa ho tšilo ea lijo: ho nyekeloa ke pelo, ho hlatsa, bohloko ba ka mpeng, lets'ollo, ho hloka takatso ea lijo, tatso ea tšepe e ka hanong.

Ka lehlakoreng la metabolism: hypoglycemia, maemong a sa tloaelehang, lactic acidosis (e hloka kalafo).

Litla-morao: lekhopho la letlalo.

Khafetsa le ho teba ha litla-morao tse tsoang mokokotlong oa lijo li ka fokotseha ka keketseho ea butle-butle ea lethal dose ea metformin. Maemong a sa tloaelehang, ho kheloha ha methapo ea methapo ea sebete kapa hepatitis ho nyamela kamora ho tlohela lithethefatsi.

Ka lehlakoreng la metabolism: ka kalafo ea nako e telele - hypovitaminosis B₁₂ (malabsorption.)

Tekanyetso le tsamaiso

Ka hare ha o ntse o ja, o nwa metsi a mangata (khalase ea metsi). Tekanyetso e beoa ka bonngoe, ho nahanoa ka phallo ea tsoekere maling.

Motsoako oa pele hangata o 500-51 mg mg, (matlapa a 1 / 2-1) ka letsatsi, keketseho e tsoelang pele ea butle-butle ea litekanyetso e ka khona ho latela phello ea kalafo.

Sesebelisoa sa tlhokomelo ea letsatsi le letsatsi ke 1 - g g, (matlapa a 1-2) ka letsatsi, ka bongata - 3 g (matlapa a 3) ka letsatsi. Ho beoa ha litekanyetso tse phahameng ha ho eke phello ea kalafo.

Ho bakuli ba tsofetseng, tekanyetso ea letsatsi le letsatsi ha ea lokela ho feta 1000 mg / letsatsi.

Tsela ea kalafo e telele.

Ka lebaka la kotsi e eketsehang ea lactic acidosis, tekanyetso ea lithethefatsi e tlameha ho fokotsoa likhatellong tse matla tsa metabolic.

Litaelo tse khethehileng

Ha e khothalletsoe mafu a tšoaetsanoang a tšoaetsanoang kapa ho ata ha maloetse a sa foleng le a sa foleng, likotsi, maloetse a bohloko a pelehi, le pele ho sebetsoa le kamora matsatsi a 2 kamora hore a etsoe opereishene, le matsatsing a 2 pele le kamora liteko tsa tlhahlobo (radiological and radiological) ts'ebeliso ea mecha ea litaba e bapisoang). Ha ea lokela ho sebelisoa ho bakuli lijong le nang le lithibelo ho kenella ka caloric (ka tlase ho 1000 kcal / ka letsatsi).Ts'ebeliso ea lithethefatsi ha e khothalletsoe ho batho ba lilemo tse fetang 60 ba etsang mosebetsi o boima oa 'mele (ka lebaka la kotsi e eketsang ea ho holisa lactic acidosis).

Hoa khoneha ho sebelisa moriana ona hammoho le lintho tse tsoang ho sulfonylurea kapa insulin. Maemong ana, ho hlokahala haholo ho lekola maemo a tsoekere ea mali.

Tšusumetso ho bokhoni ba ho khanna makoloi le ho sebetsa ka mekhoa. Ha ho na phello (ha e sebelisoa e le monotherapy). Hammoho le li-agents tse ling tsa hypoglycemic (sulfonylurea derivatives, insulin, joalo-joalo), nts'etsopele ea maemo a hypoglycemic e khonahala, moo bokhoni ba ho khanna makoloi le ho etsa lintho tse ling tse ka bang kotsi tse hlokang tlhokomelo e potlakileng le lebelo la karabelo ea psychomotor li senyehile.

Moetsi

Setifikeiti sa ho ingolisa: Verwag Pharma GmbH & Co KG, Kalverstrasse 7, 71034, Beblingen, Jeremane.

Moetsi: Dragenopharm Apotheker Püschl GmbH & Co KG, Jeremane.

Ofisi ea moemeli / mokhatlo o amohelang likopo: Ofisi ea moemeli oa k'hamphani Vervag Pharma GmbH & Co CG in the Russian Federation.

117587, Moscow, tsela e kholo ea Warsaw, 125 F, bldg. 6.

Mohala: (495) 382-85-56.

Mokhoa oa ho sebelisa: litekanyetso le kalafo

Ka hare, nakong kapa hang ka mor'a lijo, bakeng sa bakuli ba sa fumanang insulin - 1 g (matlapa a 2) makhetlo a 2 ka letsatsi ka matsatsi a 3 a pele kapa 500 mg makhetlo a 3 ka letsatsi, ebe ho tloha matsatsi a 4 ho isa ho a 14 - 1 g makhetlo a 3 ka letsatsi, kamora matsatsi a 15 moriana o ka fokotsoa o nahanela litaba tsa tsoekere maling le moriring. Tekanyetso ea letsatsi le letsatsi - - g, g.

Matlapa a retard (850 mg) a nkuoa hoseng le mantsiboea. Sekhahla se phahameng sa letsatsi ke 3 g.

Ka tšebeliso e tšoanang ea "insulin" ka tekanyo ea li-unit tse ka tlase ho 40 / ka letsatsi, moriana oa litekanyetso tsa metformin o ts'oana, ha tekanyetso ea insulin e ka fokotsoa butle-butle (ka likarolo tsa 4-8 / letsatsi ka letsatsi le leng le le leng). Ka tekanyo ea insulin ho feta likarolo tsa 40 / ka letsatsi, ts'ebeliso ea metformin le ho fokotseha ha tekanyetso ea insulin ho hloka tlhokomelo e kholo mme e etsoa sepetlele.

Lipotso, likarabo, litlhahlobo ho lithethefatsi Metfogamma 1000

Tlhahisoleseling e fanoeng e reretsoe litsebi tsa bongaka le tsa meriana. Tlhahisoleseling e nepahetseng ka ho fetelletseng ka lithethefatsi e fumaneha litaelong tse tlamelletsoeng ke moqapi. Ha ho na tlhahisoleseling e thathamisitsoeng leqepheng lena kapa leha e le efe ea sebaka sa rona sa marang-rang e ka sebetsang e le sebaka sa boipiletso ba motho ho setsebi.

Ho sebelisana le lithethefatsi tse ling

Nifedipine e eketsa ho monya, C_tlhokomelisoe liehisa ho tebela. Lithethefatsi tsa cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, le vancomycin) tse fumanehang ka har'a marang-rang li qothisana le litsamaiso tsa tsamaiso ea methapo, mme ka kalafo ea nako e telele, li ka eketsa C_tlhokomeliso ka 60%.

Ha e sebelisoa ka mokhoa o ts'oanang le li-sulfonylurea derivatives, acarbose, insulin, lithethefatsi tse sa thibeloang ke steroidal, li-inhibitors tsa monoamine oxidase, li-inhibitors tsa oxytetracycline, li-angiotensin-converting enzyme, li phahamisang likhakanyo tsa matla tse eketsang ho eketseha ha li-glucose. , epinephrine, sympathomimetics, glucagon, lihormone tsa qoqotho, thiazide le pet evymi "diuretics, derivatives phenothiazine, acid e nicotinic ka 'na fokotsa bohato hypoglycemic tsa metformin.

Cimetidine e liehisa ho felisoa ha metformin, e eketsang kotsi ea lactic acidosis. Metformin e ka fokolisa phello ea li-anticoagulants (tse tsoang ho coumarin). Ka tšebeliso e ngata ea joala ka nako e tšoanang, lactic acidosis e ka hlaha.

Likarolo tsa ts'ebeliso

Nakong ea kalafo, ho hlokahala hore ho hlahlojoe ts'ebetso ea renal. Bonyane makhetlo a mabeli ka selemo, hammoho le ponahalo ea myalgia, qeto ea dikahare tsa lactate e plasma e lokela ho etsoa. Hoa khonahala ho sebelisa Metfogamma® 1000 hammoho le sulfonylurea derivatives kapa insulin. Maemong ana, ho hlokahala haholo ho lekola maemo a tsoekere ea mali.

Kameho ea bokhoni ba ho khanna makoloi le ho sebetsa ka methapo Ha u sebelisa lithethefatsi ho li-monotherapy, ha e ame bokhoni ba ho khanna makoloi le ho sebetsa ka methapo. Ha metformin e kopantsoe le baemeli ba bang ba hypoglycemic (li-sulfonylurea, insulin, jj), maemo a hypoglycemic a ka hlaha moo bokhoni ba ho khanna makoloi le ho etsa lintho tse ling tse ka bang kotsi tse hlokang tlhokomelo e eketsehileng le karabelo e potlakileng ea psychomotor e senyehileng.