Mokhoa oa ho sebelisa lithethefatsi Glidiab MV?

Gliclazide ke sethethefatsi sa molomo se amanang le "hypoglycemic" se amanang le "mele" ea hau sulfonylureas Moloko oa bobeli. Ketso ea lithethefatsi e lebisoa ho ts'ebetsong ea β-cell in manyemehlahisang insulin, ho eketseha habonolo ha lisele tsa pherekano ho eona, ho eketsehile glucose insulin secretion litlamorao le tshusumetso ea tšebetso e makatsang glycogen synthetase ka mesifa ea mesifa. Setlhare se fokotsa nako ea nako ho tloha motsotso oa ho ja lijo ho fihlela o qala tlhahiso insulinfokotsa tsoekere ea postprandial, hape e khutlisa ba pele (ba pele) peak insulin secretion (ho fapana le lithethefatsi tse ling sulfonylureashaholo e sebetsang mokhatlong oa bobeli).

Ntle le ho laola metabolism ea carbohydrate gliclazide ntlafatsa microcirculationka ho fokotsa pokello ea liplatelete le khomarela, normalization ea methapo ea methapo, ho khutlisetsa ts'ebetso ea mmele parietal fibrinolysis.

Phekolo ea Glidiab e fokotsa khatello ea methapo adrenalinee thibela sebopeho atherosulinosis le microthrombosis. E thibela tsoelo-pele ea lintho tse sa feteng (tsa morao) lefu la tsoekere. Ka kalafo ea nako e telele, ho fokotseha hoa bohlokoa hoa bonahala proteinuriantshetsa pele ka moraolefu la tsoekere.

Ho nwa moriana, ka lebaka la phello ea ona mohato oa pele secretion ea insulin, ha e tsamaisane le ho nona haholo esita le ho rata ho fokotsa ha eona bakuli ba batenya, haeba ho loketse kalafo ya ho ja.

Tsamaiso ea molomo gliclazide e lebisa ho kenyeng ha eona ka mokhoa o phethahetseng kahare ho tšilo ea lijo. TCmax ho serum madi Lihora tse 4 (bakeng sa matlapa a MV - lihora tse 6-12). Ho kopanya liprotheine tsa plasma ho maemong a 90-95%. Ho fetoha ha metaboliki ho etsahala ka har'a sebete 'me ho lokolloa lihlahisoa tse sa sebetseng metabolism. T1 / 2 ke lihora tse 8-11 (bakeng sa matlapa a MV - lihora tse 16). Tlhahiso ea Foromo metabolites e entsoe haholo ke liphio (hoo e ka bang 70%), hammoho le mala (12%). Hoo e ka bang 1% gliclazide e pepesitsoe e sa fetoha moroto.

Matšoao a ho sebelisoa

Glidiab o bonts'itsoe mofuta oa lefu la tsoekere (NIDDM, tsoekere e sa itšetleheng ka insulin) e nang le nako e tšoanang kalafo ya ho ja le ho bolaoaho ikoetlisa mathata a itekanetseng haeba a sa sebetse nakong e fetileng.

Ts'ebeliso ea Glidiab e kopantsoe ka botlalo ho:

lefu la tsoekere ketoacidosis,
sefuba,
mofuta oa 1 lefu la tsoekere,
lefu la tsoekere /coma,
lefu le matla la sebete/seso,
hyperosmolar coma,
leukopenia,
maemo a bohloko, ka tlhoko ea ho a sebelisa insulinho kenyelletsa likotsi, tšebetso ea ho buoae kholo chesa,
paresis ea mala,
boimana,
mala,
li-pathologies tse tsamaeang le malabsorption lijo le libopeho hypoglycemia (ho kenyeletsa le mafu a tšoaetsanoang)
ea botho Hypersensitivity ho gliclazide kapa lithethefatsi tse ling
bongoaneng.

Litlamorao

Litlamorao tse atileng ka ho fetisisa le tse tebileng tsa Glidiab ke hypoglycemia, hangata e hlahisoa ke tlolo ea moriana oa litekanyetso le tse sa lekaneng kalafo ya ho ja. Letšoao la khatello ena le fapane haholo mme le ka iponahatsa: hlooho e bohlokotlala ho ikutloa o khathetseka tšohanyetso bofokolitlhokomeliso ho tšoenyeha, mabifiho se khonehe maemo a sithabetsangkarabelo e butle, ho se khone ho tsepamisa mohopolo, ho sitisoa hoa ponoho hloka thuso aphasiamathata a kelello thothomela, ho tsekela, deliriumtahlehelo ea boitšoaro spasmsho lahleheloa ke kelello hypersomniaHo phefumoloha ho sa tebang mofufutso, bradycardia.

Litlamorao tsa bobeli tsa bohlokoa ka ho fetisisa tsa corking kalafo ea Glidiab li nkuoa e le litlamorao tse mpe tse bonoang ho tsoa mpeng ea mpa, e boletsoeng dyspepsia (ho nyekeloaho teba ha matla le lets'ollo), litlolo mosebetsi oa hepatic (eketsa mosebetsitransaminase ea sebete, cholestatic jaundice), anorexia (boemong ba ho nka lipilisi ka lijo, ho teba anorexia ea fokotseha).

E kanna ea ntlafala liponahatso tsa lintho tse bohlokohaholo hlaha urticaria, makhopho a maculopapular le letlalo la letlalo le boreleli.

Ka linako tse ling o ile a bona sebopeho leukopenia, thrombocytopenia le phokolo ea mali.

Glidiab, litaelo tsa tšebeliso

Khetho ea moriana oa litekanyetso tsa moriana o bitsoang Glidiab o etsoa ka mokhoa o fapaneng ho latela lipontšo tsa kliniki NIDDM le boemo glycemia, e lekantsoeng ka mpeng e se nang letho, le kamora lihora tse peli kamora ho ja.

Qalong, ho khothalletsoa takatso ea letsatsi le leng le le leng ea 1st Glidiab 80 mg kapa letlapa la 1 la Glidiab MV 30 mg le khothalletsoa. Tekanyetso e tloaelehileng ea letsatsi le letsatsi ke 160 mg le 60 mg, mme boholo ke 320 mg le 120 mg, ka ho latellana, bakeng sa matlapa le matlapa a MV. Matlapa a tloaelehileng a Glidiab 80 mg a nooa metsotso e 30-60 pele ho lijo habeli ka lihora tse 24 (hoseng le mantsiboea). Matlapa a MV 30 mg a bontšoa hore a nooe hang hoseng ho hong le ho hong nakong ea lijo tsa hoseng. Ho eketseha ha tekanyetso ho ka etsoa ka nako ea bonyane matsatsi a 14.

Batho ba baholo le bakuli ba nang le methapo ea methapo (e nang le CC 15-80 ml / min) ha e hloke tokiso ea litekanyetso.

Bongata

Haeba ho na le overdose gliclazide hlokomela nts'etsopele hypoglycemiaka linako tse ling e fihlahypoglycemic coma.

Ketsahalong eo matšoao a bosholu bo fetang a lumellang mokuli hore a hlokomele, ho hlokahala hore a noe hanghang tharollo ea tsoekere kapa tsoekere (dextrose) Boemong ba ho se tsebe letho ba mokuli, tharollo ea methapo e bontšoa Dextrose (40%) kapa ente ea IM Glucagon (1-2 mg). Nakong e tlang, ka boemo bo bong bo tloaelehileng ba boemo, mokuli o lokela ho ja lijo tse nang le dikahare tse ngata lik'habohaedreite, molemong oa temoso khutlela ho hypoglycemia.

Tšebelisano

Ho fokotseha ha katleho ea hypoglycemic ea Glidiab ho bonoa haeba ho ka sebelisoa ka mokhoa o ts'oanang le glucocorticoids, barbituratesaudiathomimetics (Terbutaline, Epinephrine, Ritodrin, Clonidine, Salbutamol), bahanyetsi ba khalsiamo, letsoai la lithium, nicotinic acid, thiazide diureticscarbonic anhydrase inhibitors (Diacarb), Chlortalidone, Triamteren, Chlorpromazine, Furosemide, Asparaginase, Danazol, Baclofen, Diazoxide, Rifampicin, Morphine, Isoniazid, Glucagon, Phenytoin, lihormone tšoelesa ea qoqotho le estrogen (ho kenyeletsa lithibela-pelehi tsa molomo).

Keketseho ea ketsahalo ea hypoglycemic ea Glidiab e tsejoa ka ts'ebeliso ea eona e kopaneng ea lithethefatsi tsa antifungal (Fluconazole, Miconazole), Li-inhibitors tsa ACE (Enalapril, Captopril), H2-blockers (Cimetidine), likhoele (Bezafibrat, Clofibrate), NSAIDs (Indomethacin, Phenylbutazone, Diclofenac), li-salicylates, litlhare tse thibelang lefuba (Ethionamide), anticoagulants, Metsi-a-blockli-anabolic steroids CyclophosphamideMAO inhibitors Chloramphenicol, Theophylline, AllopurinolSulfonamide ea nako e telele, Fenfluramine, Pentoxifylline, Fluoxetine, Guanethidine, Reserpine, lithibelo tsa sephiri tsa tubular, Disopyramide, Bromocriptine, Pyridoxine, ethanol, hammoho le lithethefatsi tse ling tsa hypoglycemic (insulin, biguanides, acarbose).

Kamohelo e kopaneng ea Glidiab le cardiac glycosides e eketsa kotsi ea ho etsoa ventricular extrasystole.

Litlamorao tsa li-β-blockers Reserpine, Clonidine, Guanethidine e ka pata matšoao a kliniki hypoglycemia.

Litaelo tse khethehileng

Phekolo ea Glidiab e lokela ho tšehetsoakalafo e tlase ea khalorika ho kenyelletsoa hanyane lik'habohaedreite.

Ho kheloha lijong, hammoho le khatello ea maikutlo le 'mele li hloka liphetoho tsa litekanyetso gliclazide.

Nakong eohle ea phekolo, ho hlokahala hore ho hlahlojoe boemo ba glycemiaho e hlahloba ka mpeng e se nang letho le ka mor'a ho ja.

Ho lefu la tsoekerehape mehato ea ho buoa ts'ebeliso e khonehang e lokela ho nahaneloa tse nang le insulin litokisetso.

Mokuli o lokela ho tsebisoa ka monyetla oa ho etsoa hypoglycemia ha ho itima lijo, ho nka NSAIDs le Litokisetso tse nang le ethanol.

Haholo-holo e amehang ka ho khetheha litlamorao tsa lithethefatsi tsa hypoglycemic ke bakuli ba tsofetseng, bakuli ba fokolang, kapa ba sa fumaneng phepo e nepahetseng, hammoho le batho ba nang le bothata ba ho kula. hypocorticism.

Ho lokela ho ba hlokolosi ha u etsa mosebetsi o kotsi kapa o nepahetseng, hammoho le ho khanna koloi, haholo-holo nakong ea khetho ea moriana oa litekanyetso, ka lebaka la kotsi e kholo ea sebopeho hypoglycemia.

Glemaz,
Amaril,
Botle,
Amix,
Glibetic,
Diabrex,
Glianov,
Maninil,
Glibenclamide,
Diameprid,
Glimepiride,
Diapiride,
Glinova,
Meglimide,
Glurenorm,
Aletare,
Eglim jj.

Glidia MV,
Diabeteson MR,
Gliklada,
Pheta hape,
Gliclazide MR,
Ho tseba MR,
Gluktam,
Diabinax,
Glucostabil,
Diatiki,
Sethala,
Diabresid,
Osiklid.

Phihlelo ea kalafo ea Glidiab ho bakuli sehlopheng sa lilemo tsa bana ha e lekane hore e beoe bana.

Ka joala

Haeba u nooa joala ha u ntse u sebelisa lipilisi tsa Glidiab, u ka ba le boiphihleloDisulfiram-karabelo (syndrome) hlahella bohloko ba ka mpeng, ho nyekeloa/ho hlatsa, hlooho e bohloko.

Nakong ea bokhachane le pelehi

Sebelisa kalafo ea Glidiab le sefuba le ea boimana E thibetsoe.

Litlhahlobo tsa Glidiab tse fumanoeng neteng li 'maloa, empa li ntle haholo. Ho latela bakuli ba e amohelang, lithethefatsi li sebetsana ka katleho le lipontšo tse mpe. lefu la tsoekere le sa hlokeng insulin mme e na le litla-morao tse fokolang. Ka tlhaho, ha o nka Glidiab, o lokela ho boloka tse loketseng ja le ho latela litlhahiso tsa ho ikoetlisa.

Sokolla foromo le sebopeho

Foromo ea litekanyetso ea ho lokolloa ha Glidiab MV ke lets'oao le nang le tokiso e fetotsoeng: sephara-cylindrical, e tšoeu e nang le tranelate e tsoeu kapa e tšoeu, e ts'oeroe, marang-rang e amoheloa (likarolo tse 10 ka lithutsoana, ka lebokoseng la karete ea likarete tse tharo kapa tse 6).

Letlapa la 1

ntho e sebetsang: gliclazide - 30 mg,
likarolo tse thusang: "microcrystalline cellulose" - 123 mg, hypromellose - 44 mg, magnesium stearate - 2 mg, colloidal silicon dioxide - 1 mg.

Mofumahali

Gliclazide kamora ho tsamaisoa ka molomo e batla e nkiloe ka botlalo ho tsoa mokokotlong oa mpa. Ts'oaetso ea plasma ea eona e eketseha hanyane ka hanyane mme e fihla hofihlella nakong ea lihora tse 6-12. Ho ja ha ho ame ho kenngwa ha ntho.

Ka tekanyetso e le 'ngoe ea Glidiab MV letsatsi le leng le le leng, motsoako o sebetsang oa plasma ea gliclazide o fanoa lihora tse 24.

Plasma protein e tlamang ke hoo e ka bang 95%.

Metabolism e etsahala ka har'a sebete 'me e thehiloe ka mor'a moo metabolites e sa sebetseng.

T_1/2 (halofo ea bophelo) ke lihora tse ka bang 16. E hloekisoa haholo ke liphio ka mokhoa oa li-metabolites, hoo e ka bang 1% ea ntho ena e kentsoeng e sa fetoloe ka har'a moroto.

Contraindication

mofuta oa 1 lefu la tsoekere
lefu la tsoekere ketoacidosis,
lefu la tsoekere / promo,
maemo a tsamaeang le malabsorption ea lijo, ho hlaha ha hypoglycemia (mafu a tšoaetsanoang),
hyperosmolar coma,
paresis ea mala
leukopenia
e matla ea hepatic / renal ea hloleha,
mala,
ts'ebetso e kholo ea ts'ebetso ea opereishene, likotsi tse ngata, ho chesoa le maemo a mang a hlokang kalafo ea insulin,
tiba e kopantsoeng le miconazole, danazole kapa phenylbutazone,
lilemo tse 18
ho ima le ho nyekeloa,
mamello ea motho ka mong ho likarolo leha e le life tsa moriana, hammoho le sulfonamides le tse ling tse tsoang ho sulfonylurea.

Se amanang (Glidiab MV e behiloe tlasa tsamaiso ea bongaka):

febrile syndrome
bokhoba ba joala
phepo e sa lekaneng / e sa khaotseng,
pituitary / adrenal ho haella,
mafu a matla a tsamaiso ea methapo ea pelo (ho kenyelletsa le lefu la pelo, lefu la pelo),
renal / Ho hloleha ha sebete,
hypopituitarism,
glucose-6-phosphate dehydrogenase ea haelloa,
tšebeliso ea nako e telele ea li-glucocorticosteroids,
Lefu la qoqotho le tsoela pele ka ts'ebetso ea lona.
botsofali.

Litaelo tsa ho sebelisa Glidiab MV: mokhoa le litekanyetso

Glidiab MV e nooa ka molomo, nako e le 1 ka letsatsi nakong ea lijo tsa hoseng.

Tekanyo ea lithethefatsi e khethoa ke ngaka ka bonngoe ho ipapisitse le lipontšo tsa kliniki tsa lefu lena, tsoekere e potlakileng le lihora tse peli kamora ho ja.

Tekanyetso ea pele ea letsatsi le letsatsi ke piritsi e le 'ngoe. Nakong e tlang, haeba ho hlokahala, eketsa lethal dose ka ho emisa bonyane libeke tse peli. Sekhahla se phahameng ke matlapa a 4 ka letsatsi.

Ho a khonahala ho fetoha ho tloha Glidiab ho Glidiab MV ka lethal dose ea letsatsi le letsatsi ea matlapa a 4-5.

Pheko e ka kopanngoa le li-agents tse ling tsa hypoglycemic: biguanides, insulin kapa alpha-glucosidase inhibitors.

Ho sebelisana le lithethefatsi

Motsoako oo tsoekere ea mali e ka eketsang (e fokolisa phello ea gliclazide):

danazol: ho kopanya ha ho khothalletsoe, setlhare se na le ts'oaetso ea lefu la tsoekere, haeba ho sa khonehe ho se sebelisa ka setlhare se seng, khatello ea tsoekere maling e lokela ho lekoloa, tekanyo ea Glidiab MV e ka fetoloa ke ngaka nakong ea phekolo e kopanetsoeng le kamora hore e phethoe,
chlorpromazine (ka tekanyetso ea letsatsi le letsatsi ea 100 mg): motsoako o hloka tlhokomeliso, hobane ho na le keketseho ea khatello ea tsoekere maling le ho fokotseha ha secretion ea insulin, haeba ho sa khonehe ho e khutlisetsa ka moriana o mong, khatello ea tsoekere maling e lokela ho lekoloa, nakong ea phekolo e kopaneng le ka mor'a ho phethoa, ngaka e ka 'na ea hlahlojoa. tekanyetso e ntlafalitsoeng ea Glidiab MV,
tetracosactide le glucocorticosteroids (ts'ebeliso ea lehae / ea boits'oaro: tsamaiso ea methapo, bokantle le tsamaiso ea kantle): motsoako o hloka tlhokomeliso, hobane ho na le keketseho ea khatello ea tsoekere ea mali ka nts'etsopele ea ketoacidosis, ho khothaletsoa hore ho hlahlojoe ka hloko khatello ea tsoekere ea mali, haholoholo qalong ea kalafo. kalafo mme kamora hore e phethoe ke ngaka, tekanyetso ea Glidiab MV e ka fetoloa,
salbutamol, ritodrin, terbutaline (tsamaiso ea methapo): motsoako o hloka tlhokomeliso,
anticoagulants (ka ho khetheha warfarin): ketso e eketsehileng ea li-anticoagulants (phetoho ea litekanyetso e ka hlokahala).

Motsoako oo menyetla ea ho ba le hypoglycemia e eketsehang (khato e eketsehileng ea gliclazide):

miconazole (ts'ebetso ea kemiso kapa ea lehae ka sebopeho sa gel ho mucous membrous ea molomo): motsoako o kopantsoe, hobane hypoglycemia e ka fetoha ho ba komisi.
phenylbutazone (tsamaiso ea methapo): motsoako ona ha o khothalletsoe, haeba ho sa khonehe ho o nkela setlama se seng, khatello ea tsoekere maling e lokela ho lekoloa, tekanyo ea Glidiab MV e ka fetoloa ke ngaka nakong ea phekolo ea motsoako le kamora hore e phethoe,
ethanol: motsoako ha o khothalletsoe, o amanang le hypoglycemia e atileng le menyetla ea ho ba le komello ea hypoglycemic,
li-agents tse ling tsa hypoglycemic (insulin, alpha-glucosidase inhibitors, metformin, thiazolidinediones, dipeptidyl peptidase-4 inhibitors, li-drug glucagon-like peptide-1 agonists), li-anti-insulin tse khahlanong le ho ruruha, fluconazole, beta-adrenergic agents, neurotransmithibitors.₂- histamine receptors, monoamine oxidase inhibitors, clarithromycin, sulfonamides: motsoako o hloka tlhokomeliso.

Litšoantšiso tsa Glidiab MV ke: Diabeteson MB, Diabefarm MV, Gliclazide Canon, Glidiab, Gliclada, Diabetesalong, Diabinax, Diabefarm.

Tloaelo e akaretsang

Moriana "Glidiab MV 30" o nkoa e le analogue ea Russia ea lithethefatsi tsa Mafora "Diabeteson MV". E hlahisoa ke Semela sa Lik'hemik'hale sa Akrikhin le Setlama se Setereke sa Moscow.

Phekolo ena e bua ka li-agent tsa hypoglycemic tsa molomo tse fumanehang ka mokhoa o ntlafalitsoeng. 'Mala oa sebopeho sa bona o mosoeu kapa tranelate, e kanna ea ba maraka. Matlapa a tšoana le chamfers e bataletseng.

Ho paka ha bareki ke pakete. E kanna ea ba le matlapa a 30 kapa a 60, a kentsoe ka har'a lipolanete tsa blister.

Ho fapana le moriana oa "Diabeteson MV" o nang le tekanyetso ea 0,060 g ea gliclazide, moriana oa "Glidiab MV" o na le motsoako o tšoanang o sebetsang makhetlo a mabeli a tlase, e leng 0,030 g.

Likarolo tse sa sebetseng tsa letlapa li kenyelletsa hydroxypropylmethyl cellulose, limolek'hule tsa aerosilic, magnesium stearate, microcrystalline cellulose.

Ho boetse ho na le lithethefatsi "Glidiab" ka tokollo e tloaelehileng ea ntho e sebetsang. Motsoako ka ho pepa e le 'ngoe ke 0.08 g ea gliclazide.

E sebetsa joang

Litaelo tsa tšebeliso e hokahantsoeng le moriana oa Glidiab MV li hlalosa phello ea glyclazide, e tsosang secretion ea insulin ka liseleng tsa located-li-pancreas.

Tlas'a tšusumetso ea litafole, ts'ebetso ea lekunutu ea "insulin" ea limolek'hule tsa "glucose" e eketseha, 'me lithane tsa pherekano li ba le kutloelo-bohloko haholo ho lihormone tsa insulin.

Mussage glycogen synthetase, ho ba enzyme ea kahare, e sebetsa haholoanyane. Ho na le ho fokotseha ha nakoana ho tloha ho qalang ha ho ja ho fihlela ho lokolloa ha lihormone. Insulin secretion e khutlisetsoa tlhōrōng ea pejana, e khethollang gliclazide le li-foremors tse ling tsa sulfonylurea, ketso eo e etsahalang mohatong oa bobeli. Boemo ba gluprose ea postprandial boa fokotseha.

Ho na le ntlafatso ea microcirculation ka lebaka la tumellano le khokahano ea lisele tsa liplatelete, ho lumellana ha boteng ba methapo ea methapo, ho fokotseha ha nts'etsopele ea mekhoa ea micothrombotic le atherossteosis, le tsosoloso ea karabelo ea ho felisoa ha tlhaho ha methapo ea mali. Monyetla oa karabelo ea mekhoa ea li-receptor methapong ea mali ho limolek'hule tsa adrenaline oa fokotseha.

Moriana o khona ho theola mofuta oa tsoekere oa retinopathy sethaleng se sa feteng. Phekolo ea nako e telele le sethethefatsi sena maemong a ho senyeha ha lefu la tsoekere ho likarolo tsa likarolo tsa renal tse ikarabellang bakeng sa ho fera e ka fokotsa haholo tlhahiso ea liprotheine tse ka moriring.

Moriana ha o phahamise boima ba 'mele, empa o mpa o a fokotsa ka lebaka la phello mohato oa pele oa insulin. Ha e tsose insulinemia e eketsehileng.

E sebelisetsoa eng?

Lingaka li khothaletsa ho sebelisa lithethefatsi ka tsoekere e phahameng ea mali ea degree ea bobeli. Phekolo e etsoa ka mokhoa o sa lekanang oa ho ja le ho ikoetlisa ka ho leka-lekaneng.

Bakeng sa moriana oa Glidiab MV, matšoao a amana le thibelo ea ho senyeha hoa mafu a lefu la tsoekere, a tšoauoang ke nephropathy, retinopathy, myocardial infarction le stroke.

Mokhoa oa ho sebelisa

Litekanyetso tsa lithethefatsi li khethoa bakeng sa mokuli ka mong, ho ela hloko lipontšo tsa lefu lena, khatello ea tsoekere ka mpeng e se nang letho le metsotso e 120 kamora ho ja.

Bakeng sa moriana "Glidiab MV", litaelo tsa tšebeliso li fana ka tekanyetso ea pele ea letsatsi le letsatsi ea 0,03 g, e lekanang le letlapa le le leng. Ts'ebetso ena e bontšoa ho bakuli ba tsofetseng kamora lilemo tse 65. Moriana o sebelisoa ka molomo mohala o le mong hoseng ha lijo tsa hoseng.

Haeba ho hlokahala, litekanyetso li eketseha ka mor'a libeke tse ling le tse ling tse peli. Boholo ba letsatsi le le leng bo lumelloa ho nka 0,2020 g, e lekanang le matlapa a 4.

Moriana "Glidiab MV" o sebelisoa ho fapana le lithethefatsi tsa lebitso le ts'oanang le ho lokolloa ho tloaelehileng, ho noang matlapa a 1-4 ka letsatsi.

E kopantsoe le moemeli oa hypoglycemic e thehiloeng ho Biguanide, alpha-glucosidase inhibitor ea limolek'hule tsa insulin.

Maemong a mosebetsi o sa sebetseng hantle oa renal ha tlhaho e fokola kapa e itekanetseng, ha tekanyo ea tlhahiso ea "metabolinine" e sa feta litone tse 0,080 ka motsotso, litekanyetso li sa fokotsoa.

Ha e se ho nka

Matlapa a Glidiab MV ha a khothalletsoe hore a sebelisoe ka mokhoa oa pele oa lefu la tsoekere, ka keketseho ea li-keton ka moroto, le gastric paresis, hyperosmolar, lefu la tsoekere le lefu la ho bola, ka ho buoa haholo le ho lemala, lits'ebetso tse bohloko ha insulin e hlokahala. kalafo.

Contraindication ke tlolo e matla ea ho sebetsa ha hepatic kapa renal, ho kenella ka mpeng, liphetoho mokhoeng oa lijo, nts'etsopele ea boemo ba hypoglycemic.

U ke ke ua sebelisa moriana ona bakeng la feberu, leukopenia, boimana, matsoele le ho se mamelle litheko tsa moriana haholo.

Ho hlokahala tlhokomeliso ha u fana ka moriana, ho beha tlhokomelo e khethehileng le khetho ea litekanyetso ho bakuli ba ts'ehetsoeng joala le mathata a tšoelesa ea qoqotho.

Litšobotsi tsa kalafo

Bakeng sa moriana "Glidiab MV", litaelo tsa tšebeliso li bonts'a tlhoko ea ho e kopanya le lijo tse nang le khalori e tlase, ho kenyelletsa le litaba tse nang le lik'habohaedreite tse tlase. Ho beha leihlo khafetsa ho bokellana ha tsoekere maling maling ho tloha hoseng pele le kamora ho ja hoa hlokahala.

Haeba ho bile le ts'ebetso ea ho buoa kapa ho phumoloa ha lefu la tsoekere, ho ka hlahisoa ha li-insulin.

Ho na le litemoso mabapi le ho ba teng ha ts'ebetso ea hypoglycemic ka tšebeliso ea joala ea ethyl, ntho e seng khahlanong le 'mele ea antiidal le ho hloka phepo e nepahetseng. Ho nwa joala ho ka baka lefu le kang "discriram", ha hlooho le mpa li utloile bohloko, ho nyekeloa le pelo le ho hlatsa li khonahala.

Litekanyetso tsa moriana li lokela ho fetoloa nakong ea khatello ea maikutlo le ea maikutlo le lijo tse sa lebelloang.
Haholo-holo e amehang ka phello ea lithethefatsi ke batho ba tsofetseng, bakuli ba nang le phepo e sa leka-lekanang kapa ba sa foleng, bakuli ba fokolang ba nang le bothata ba ho haelloa ke tsamaiso ea adrenal-pituitary.

Mehatong ea pele ea ts'ebeliso ea lithethefatsi ha u khetha litekanyetso, haeba ho na le menyetla ea koluoa ea hypoglycemic, ha ho hlokahale hore u etse liketso tse hlokang tlhokomelo e matla le karabelo e potlakileng ea psychomotor.

Lintho tse fapaneng tse tla etsahala

Bakeng sa Glidiab MV, thupelo e kenyelletsa tlhaiso-leseling mabapi le tlhekefetso ho litho tsa endocrine nakong ea ts'ebetso e mpe ho regimen ea tšebeliso ea lipilisi le nakong ea phepo e fosahetseng. Ka tloaelo, ho fokotseha ha tsoekere maling maling ho baka tšenyo ea hlooho, mokhathala, tlala, ho hloka thuso, ho tšoenyeha, ho fokola hang hang, ho ba mabifi, ho tsepamisa mohopolo, le ho sithabela maikutlo. Hape, ho na le liphetoho mokhoeng oa pono, ho thothomela, ho ferekana kelellong le tsitsipano ea maikutlo, ho tsekela, ho ferekana kelellong, ho hema ka mokhoa o sa tsitsang le ho fokotseha ha sekhahla sa pelo.

Ho se sebetse hantle hantle ha litho tsa ka mpeng ho sebetsa ka tsela e sa sebetseng hantle, ho nyekeloa ke pelo, lets'ollo, ho hloka takatso ea lijo, ho senyeha ha lisele tsa sebete, cholestatic jaundice, le keketseho ea katleho ea li-enzyme tsa transaminase.

Mekhoa e sa rateheng tsamaisong ea hematopoietic e amahanngoa le ho fokotseha ha lipalo tsa hemoglobin, platelet le leukocyte.

Setlhare se ka baka ponahalo ea ho kulisa ka mokhoa oa ho hlohlona, urticaria, leqhetsoana ea maculopapular.

Kenyelletso e fetelletseng

Litaelo tsa tšebeliso e hokahantsoeng le pheko ea Glidiab MV li lemosa khahlanong le ho fetella, ho hlahisoang ke ho fokotseha ha khatello ea tsoekere maling plasma. Ka tšebeliso e matla ea lithethefatsi, nts'etsopele ea komello ea hypoglycemic e ka khonahala.

Ho e felisa, motho o lumelloa ho ja li-hydrocarbon tse nkiloeng hantle, mohlala, sengoathoana sa tsoekere. Ha motho a sa tsebe letho, tharollo ea 40% ea dextrose kapa tsoekere e kenngoa mothapong, 'me tsoekere e kenngoa ka har'a mesifa ka bongata ba 1 mg. Haeba mokuli a tsoha, joale o qobelloa ho ja li-hydrocarbon tse nkiloeng hantle ho qoba ho pheta-pheta tlhaselo ea hypoglycemic.

Ho kopana le meriana

Mosebetsi hypoglycemic ya moriana o "Glidiab bapisa le 30 mg," ka ntlafatsoa ke kenyelletsa e tšoanang angiotensin fetola potlakisang tsebetso ea lik'hemik'hale sesitisa le Monoamine dihydrobenzophenanthridine mofuta receptor blocker lihlopha tsa beta adrenozavisimyh le H2 gistaminozavisimyh thehiloeng cimetidine, le flukonazolovyh lithethefatsi mikonazolovyh antifungal, bao e seng steroidal-ba khahlanong le a hlabang mahlahana phenylbutazone, indomethacin, diclofenac.

Matla a matlapa a ntlafalitsoe ka litlhare le li-bezafibrate, lithethefatsi tse khahlanong le lefuba tse tsoang sehlopheng sa ethionamide, salicylates, li-compact tsa anticoagulant tse sa hlophiseng sebopeho sa coumarin, anabolic steroids, cyclophosphamides, chloramphenicol, sulfonamides e nang le phello e telele.

Setlhare sena se fokotsa tsoekere e ngata haholo maling ha se sebelisa li-blockter tsa tubular, joala ba ethyl, acarbose, biguanide, insulin.

Ho fokotsa phello ea hypoglycemic ea litafole ho bakoa ke li-barbiturates, lithethefatsi tse thehiloeng ho epinephrine, clonidine, terbutaline, rhytodrin, salbutamol, hape phenytoin, inhibitors ea encyrase ea carbonic anhydrase e joalo ka acetazolamide, thiazide diuretics, lihormone tse nang le li-lithium tse nang le meriana.

Limolek'hule tsa joala ba ethyl li khona ho sebetsa ho gliclazide ka ts'ebetso ea ts'ebetso e kang disulfiram.

Karolo e sebetsang ea matlapa e baka ho theoha ho sa lekanyetsoang le ho senyeha ha mesifa ea myocardial ha e kopantsoe le pelo glycosides.

Beta-blockers, clonidine, reserpine, lithethefatsi tsa "guanethidine" li-mask tsa bongaka tsa bongaka.

Maikutlo a mamello

Bohlokoa ha se feela litaelo tsa ts'ebeliso tse hokahaneng le moriana oa Glidiab MV. Litlhahlobo li bua ka seo bakuli ba se nahanang ka katleho ea moriana. Sesebelisoa sena se thusa bakuli ba bangata ho fokotsa khatello ea "glucose" maemong a tloaelehileng, 'me hammoho le phepelo e fetola mokhoa oa bophelo oa mokuli.

Batho ba hlokomela hore karolo e ntle ea matlapa ke ts'ebeliso ea bona e bonolo hoseng. Motšehare, u ke ke ua hopola bohlokoa ba kalafo.

Litlhahlobo tsa "Glidiab MV" tsa bongaka li ka utluoa li bile li le mpe ka tlhaho, e amanang le ho se sebetse hantle ha sesebelisoa sena. Hangata sena se etsahala ha litekanyetso li sa nepahala, ha ho fanoe ka tekanyo e nyane ea moriana.

Mefuta le sebopeho sa tokollo

E sebetsang: 0,03 g ea gliclazide
Mothusi: hypromellose, MCC, aerosil, E572.

Lipilisi tsa mofuta oa silinda e sephara e metenya e metenya, e tšoeu kapa e bolila. Ho nyarosoa hoa sebopeho ha se sekoli. E kenya likotoana tse 10 ka marang-rang. Ka paketeng ea karete - liphutheloana tse 3 kapa tse 6 tsa contour, buka ea mosebelisi.

Pholiso ea thepa

Lithethefatsi tse nang le phello ea hypoglycemic e thehiloeng glycazide, e fumanoang molokong oa bobeli oa sulfonylurea. E hlohlelletsa tlhahiso ea insulin 'meleng, e ntlafatsa kutloisiso ea lithane ho insulin le phello ea sephiri sa "insulin". E khutlisetsa tlhoro e tloaelehileng ea insulin secretion, e ntlafatsa microcirculation, e fokotsa ho kopana ha liplatelete, e khutlisetsa boteng bo hlokahalang ba methapo.

Ho nka sethethefatsi sena ha ho na karolo ea ho bokelloa ha liponto tse eketsehileng, kaha ho ama haholo ho theoa ha tlhoro ea pejana ea insulin.

Mokhoa oa kopo

Setlhare se etselitsoe feela kalafo ea batho ba baholo. Matlapa a Glidiab MV, ho latela litaelo tsa tšebeliso, a nkuoa hang ka letsatsi, a loketse hoseng haholo ka lijo. Lipilisi li entsoe li felletse, li ke ke tsa longoa kapa hona ho sithabetsoa.

Haeba ka lebaka le itseng kamohelo e ne e hlotsoe, joale ho pheta kameho ka ho siea ka tekanyetso e habeli ha ho khothalletsoe. Pilisi e sa lebaleheng e lokela ho nooa hoseng ho latelang. Litekanyetso tsa lithethefatsi, joalo ka lithethefatsi life kapa life tsa hypoglycemic, li lula li khethoa ka bomong ho mokuli ka mong ho latela bopaki ba hae ba tsoekere ea mali le hemoglobin.

Motsoako oa pele o khothalelitsoeng ke 30 mg ka letsatsi. Hamorao, e ka fetoloa ho 60, 90 le 120 mg. E lumelloa ho eketsa tloaelo ea letsatsi le letsatsi ea lithethefatsi ka khoeli feela kamora lethal dose la pele. Mokhelo ke maemo ha kalafo ea pele e sa fane ka sephetho se lebelletsoeng, mme boemo ba tsoekere bo ne bo lula bo le boemong bo tšoanang (pele ho kalafo). Boemong bona, litekanyetso li ka eketsoa pejana - kamora matsatsi a 14.

HF e nang le kalafo ea tlhokomelo ke 30-120 mg.

Haeba ho hlokahala ho fetisetsa mokuli ka Glidiab 80 mg ho lipilisi tse nang le ts'ebetso ea nako e telele (MV 30 mg), e etsoa kamora ho hlahloba boemo ba glucose ka karolelano ea 1: 1. Haeba mokuli a kile a nka lithethefatsi tse ling tsa hypoglycemic, phetisetso e tlameha ho etsoa ka lipalo tsa lithethefatsi tse fetileng tsa HF le nako ea ho tlosoa. Ha ho na tlhoko ea ho sheba nako ea phetoho, SN ea pele ea Glidiab MV ke 30 mg, ka mor'a moo e ka fetoloa.

Haeba mokuli a noele lipilisi nako e telele ea ho hlahisa motsoako o sebetsang, khefu e lokela ho nkuoa ho thibela sephetho sa tlatsetso. Kamora sena, o ka qala ho nka moriana o telele ka litekanyetso tsa letsatsi le letsatsi tsa 30 mg.

Phetoho ea litekanyetso ka lilemo tsa bakuli ba tsofetseng (65+) ha e hlokehe. Bakeng sa batho ba kotsing, 30 mg ea CH e boletsoe.

Thibelo ea mathata a lefu la tsoekere, litekanyetso tsa letsatsi le letsatsi li ka eketsoa ho boleng bo phahameng ba 120 mg e le mohato o mong oa ho ja le ho ikoetlisa. Ho amohela ho etsoa ho fihlela matšoao a tloaela, ho nahanela kotsi ea hypoglycemia.

Boimana, HB

Ha ho ratehe haholo hore basali ba sebelise lithethefatsi tsa molomo tse fokotsang tsoekere ea mali nakong ea pelehi ea ngoana, hobane ha ho na bopaki ba polokeho ea Glidiab MV.

Ha a ntse a itokisetsa ho ima kapa ha e etsahala khahlanong le semelo sa matlapa a Glidiab MV, moriana o lokela ho hlakoloa mme mosali o lokela ho fuoa kalafo ea insulin.

Ha ho na data e tšepahalang ea hore na ntho e sebetsang e fetela ka lebeseng la matsoele, ka hona, ho sa rateheng haholo ho kopanya lithethefatsi tsa hypoglycemic le lactation. Nakong ea ho nka litafole tsa HB, e lokela ho hlakoloa e le hore e se ke ea baka tsitsipano ea tsoekere ea mali ho ngoana.

Tšebelisano ea lithethefatsi

Nakong ea kalafo le matlapa a Glidiab MV, bokhoni ba gliclazide ba ho sebetsana le lintho tsa lithethefatsi tse ling bo lokela ho ananeloa.Ho kotsi haholo e ka ba motsoako le lithethefatsi tse eketsang phello ea gliclazide, hobane ts'okelo ea hypoglycemic coma e eketseha ka sekhahla.

Ho thibetsoe ka thata ho kopanya phekolo ea Glidiab MV le Miconazole (systemic kapa kantle ka sebopeho sa gel), kaha sena se etsa hore ho be le mofuta o boima oa komisi o ka lebisang lefung.

Ha ho kgothaletswe ho kopanya sethethefatsi le phenylbutazone ka lona lebaka le tšoanang. E lokela ho nkeloa sebaka ke sethethefatsi se seng se thibelang boteng. Haeba ho sa khonehe ho e hlakola, mokuli o lokela ho hlokomela likotsi tse ka bang teng le tlhoko ea ho lula a hlahloba tsoekere e maling.

Ha hoa lumelloa ho kopanya le lino tse tahang kapa lithethefatsi tsa ethanol, kaha joala bo khothalletsa nts'etsopele ea hypoglycemic coma.

Hona le lithethefatsi tse 'maloa tse ka boletsoeng ka tlhokomeliso hammoho le Glidiab MV. Lithethefatsi tse joalo li kenyelletsa insulin, metformin, alpha-glucoside inhibitors, beta-blockers, sulfonamides, NSAIDs, jj. Haeba ho hlokahala, ts'ebeliso ea bona e tlameha ho betsoa leihlo ka hloko bakeng sa matšoao a sa batleheng.

Danazole o na le ts'oaetso ea lefu la tsoekere, o fokolisa phello ea glycationis, 'me o thusa ho eketseha ha khatello ea tsoekere maling. Haeba ho sa khonehe ho khutlisetsa lithethefatsi ka sethethefatsi se seng, mokuli o lokela ho lekola boemo ba tsoekere kamehla ha ho hlokahala, litekanyetso tsa Glidiab MV li lokela ho fetoloa.

Chlorpromazine e eketsa tsoekere ea mali mme e fokotseha ho kopana ha insulin. Ho laoloa khafetsa ha tsoekere ho batho ba nang le lefu la tsoekere ho hlokahala, boikemisetso bo hlokolosi ba litekanyetso tsa gliclazide ka ts'ebeliso e kopaneng ea Glidiab MV nakong ea kalafo le Chlorpromazine le kamora ho itokolla.

Lithethefatsi tse nang le corticosteroids ka mokhoa ofe kapa ofe oa kopo (kantle, ea lehae, intravenous kapa rectal) li eketsa khatello ea glucose mme li kenya letsoho ho hlaha ha ketoacidosis. Ha e kopantsoe le mofuta ona oa lithethefatsi, ho hlahlojoa tsoekere ea mali kamehla hoa etsoa mme ho hlokahala ho tseba ka hloko hore na moriana o sireletsehileng ka ho fetisisa nakong ea nako e tšoanang le kamora ho fela ha kalafo ea lihormone.

Ka thupelo e kopaneng le li-anticoagulants, hoa khoneha ho ntlafatsa ketso ea bona. Ho hlokahala phetoho ea moriana.

Litlamorao

Ho nka matlapa a Glidiab MV ho ka tsamaellana le karabelo e sa rateheng ea 'mele.

Joalo ka lithethefatsi tsohle tsa sehlopha sa sulfonylurea, moriana o ka baka hypoglycemia haeba matlapa a nooa ka mokhoa o sa tsotelleng mme haholo-holo hangata ka lijo tse se nang letho. Maemong a joalo, boemo bo tsamaea le:

Ho opeloa ke hlooho
Tlala e matla haholo
Ho nyekeloa ke pelo, makhetlo a ho hlatsa
Mokhathala
Ho hloka boroko kapa ho otsela
Ho teneha ho hoholo
Nyakallo e nyarosang
Thibelo ea maikutlo
Tšitiso
Ho sithabela maikutlo
Ho hloka tsebo, puo le pono
Ho tsekela
Maqhubu
Ho phefumoloha ho sa feleng
Delirium
Maemong a tebileng, ho lahleheloa ke ho tseba ka ho akheha kapa ho shoa ka mor'a moo hoa khoneha.

Hape, mokuli a ka ba le litlatsetso tse ling:

Ho eketsa mofufutso
Letlalo la letlalo
Kholo ea BP
Tachycardia
Arrhythmia
Angina pectoris.

Maemong a mang, ho nka litafole ho ka tsamaisana le mathata a mang a litho tse ling:

Phekolo ea ka mpeng: ho nyekeloa ke pelo, ho hlatsa, ho opeloa ke mpa, lets'ollo kapa ho sokela. Ho qoba maemo a sa batleheng kapa ho fokotsa matla a bona, ho khothalletsoa hore matlapa a nooe le lijo.
Letlalo: makhopho, ho hlohlona, edema ea Quincke, erythema, maikutlo a liphihlelo.
Litho tsa Hematopoietic: anemia, leukopenia, thrombocytopenia. Maemo ke a nakoana: a feta a bona ka mor'a ho hlakoloa ha moriana.
Sebete: ts'ebetso ea li-enzyme, maemong a sa tloaelehang - hepatitis. Haeba ho na le matšoao a jaundice ea cholestatic, kalafo e lokela ho felisoa.
Mekhoa ea pono: ho fokotseha hoa matla a bonono (hangata ho etsahala qalong ea thupelo ka lebaka la liphetoho tsoekere).

Litla-morao tse ling tse ikhethang tsa litokisetso tsa sulfonylurea li kenyelletsa:

Erythropenia
Boloetse
Vasculitis
Hyponatremia
Agranulocytosis.

Lipehelo le maemo a polokelo

Glidiab ke setlhare se fanoang ke ngaka.

Boloka matlapa a le sebakeng se omileng, se sa fumaneheng mongobo le khanya ea letsatsi, ka mocheso o fihlang ho 25 ºС. Ho latela maemo ana, bophelo ba sefuba ba Glidiab ke lilemo tse 4, 'me Glidiab MV ke lilemo tse 2.

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Molao-motheo oa moriana

Moriana bakeng sa kalafo ea lefu le "monate" la mofuta oa bobeli oa fumaneha ka sebopeho sa tafole, motsoako o ka sehloohong oa lithethefatsi ke glyclazide. Ho hlophisoa ha matlapa ho kenyelletsa likarolo tse ling - cellcose ea microcrystalline, stearate ea magnesium le lintho tse ling.

Kakaretso "MV", e fumanehang ka lebitso la moriana, e emetse tokollo e fetotsoeng. Tlhahlobo ea lingaka e re nuance ena e u lumella ho sebelisa moriana ona hang ka letsatsi.

Ntho ea bohlokoa nakong ea ho monya e thusa ho tsosa tšebetso ea mesifa ea glycogen synthetase le tlhahiso ea "insulin" ea 'mele. Ntle le moo, motsoako o ka sehloohong o etsa qeto ea ts'ebetso ea sephiri ea "insulin", e lebisang ho teba hoa kutlo ho boemo ba sele.

Ha e bohlokoa le ho feta ke taba ea hore matlapa a Glidiab a thusa ho fokotsa sekhahla pakeng tsa ts'ebeliso ea lijo le qaleho ea tlhahiso e sebetsang ea insulin. Ho hlakeloa pheko ho bontša hore tšebeliso ea lithethefatsi e theola tlhoro ea boemo ba hyperglycemic, ha ho ntse ho khutlisoa tlhoro ea pejana ea tlhahiso ea lihormone.

Lintho tsena kaofela tse ka holimo li na le phello e tobileng ho metabolism ea carbohydrate le microcirculation. Ho sebelisoa ha sethethefatsi Glidiab ho fokotsa menyetla ea ho fetoha le liphetoho tsa atherosselotic methapong ea mali.

Ka lebaka la botle ba foromo ea litekanyetso, tekanyetso e le 'ngoe ka letsatsi e tiisa ts'ebetso ea phekolo e sebetsang ea ntho e sebetsang ka plasma ka lihora tse 24.

Litaelo tsa ho sebelisoa ha matlapa

Mofuta oa lithethefatsi Glidiab MB o bonts'a moriana o khothalletsoa bakeng sa kalafo ea lefu la tsoekere ho kopantsoe le phepo e tlase ea carb le boikoetliso bo nepahetseng ba 'mele.

E le molao, kamehla moriana o sebetsa e le oona feela mokhoa oa ho theola tsoekere e maling. Ke maemong a ikhethang feela moo ho ka khothalletsoang kalafo e rarahaneng ea lefu lena. Mohlala, hammoho le litokisetso tse tsoang sehlopheng sa Biguanide.

Litekanyetso tsa moriana li fanoa ho ipapisitsoe le matšoao a tsoekere maling ka mpeng e se nang letho, hammoho le lihora tse peli kamora lijo.

Ho Glidiab, litaelo tsa tšebeliso li fana ka leseli le latelang:

Matlapa a khothalletsoa ho nooa hang ka letsatsi, nako e nepahetseng ke hoseng pele ho lijo.
Ka karolelano, litekanyetso ka letsatsi ke 80 mg, ho kenyeletsoa bakuli ba tsofetseng (ba fetang 65).
Haeba phello ea kalafo e sa lekana, hoa utloahala ho eketsa butle-butle litekanyetso ka matsatsi a 14.
Tekanyo e phahameng ka ho fetisisa ka letsatsi ha e fetang 200 mg.

Haeba mokuli a senyehile ts'ebetso ea sebete le a liphio, joale tokiso ea lithethefatsi ea Glidiab MV ha e hlokehe.

Theko ea lithethefatsi, moo bophahamo ba ntho ena e leng 80 mg (matlapa a 60 ka pakete) ke li-ruble tse 134. Theko ea matlapa a 60 ho litekanyetso tsa 30 mg ke li-ruble tse 130. Glidiab MB e theko e phahameng ho feta, theko ke ea li-pcs tse 60. 80 mg e ngoe le e ngoe ke li-ruble tse 185.

Menahano ea lithethefatsi

Maemong a 'maloa, Glidiab ha a eletsoe ho fana ka taelo ka lebaka la ho ba teng ha litlatsetso, monyetla o moholo oa mathata a tsoang ts'ebetsong ea methapo ea methapo le tsamaiso ea methapo ea pelo.

Tabeng ena, ho khothalletsoa lithethefatsi tse tšoanang. Litšoantšiso tsa Glidiab ke: Foromo, Amaryl, Diabrex, Maninil, Glurenorm le lithethefatsi tse ling bakeng sa kalafo ea lefu la tsoekere.

Ho fetola moriana ka moriana o le mong kapa o mong ho lokela ho etsoa feela ke ngaka e eang, ha ho letho le leng.

A re ke re hlahlobeng litlhahlobo ka ho qaqileng haholoanyane:

Formetin ke sethethefatsi se khothalletsoang ho alafa lefu la tsoekere la mofuta oa 2 ha kalafo ea lijo e se e sa sebetse ka botlalo. Hangata e khothalletsoa hammoho le lithethefatsi tse tsoang ho sulfonylurea.
Matlapa a Maninil a na le "motsoako o ka sehloohong oa motsoako" glibenclamide, ke litokollo tsa sulfonylurea. Setlhare se khothaletsa tlhahiso ea "insulin" e sebetsang, e fana ka phello e ntle ea insulin.
Glibenclamide e laeloa mofuta oa bobeli oa lefu la tsoekere, ha ho khonehe ho lefella patala ka lijo le lipapali. Litekanyetso li behiloe ho latela lipontšo tsa tsoekere, li ka fapana ho tloha ho 2,5 ho isa ho 15 mg. Ho eketsa makhetlo a mangata ka letsatsi.
Amaryl - moemeli oa hypoglycemic, o laetsoe kalafo ea mofuta oa bobeli oa bokuli e le eona feela lithethefatsi kapa hammoho le insulin kapa metformin. E le molao, kalafo e nang le moriana ona e etsoa ka nako e telele.

Drug Glidiab le analogues ea eona li sebetsa hantle haholo kalafong ea lefu le "monate". Leha ho le joalo, hammoho le thepa e ntle, ba na le li-contraindication le litlamorao. Ka hona, ho khethoa ho lokela ho etsoa feela ke ngaka.

Ho nwa lipilisi ho thusa mmele ho fokotsa maemo a tsoekere le ho a tsitsisa ka tekanyo e hlokahalang. Empa, molemong oa ho ntlafatsa katleho ea ts'ebeliso ea lithethefatsi, mokuli o tlameha ho latela lijo le ho ikoetlisa ho matlafatsa kutloisiso ea lisele tse bonolo ho tsoekere.

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