Diphenhydramine - litaelo tsa tšebeliso, foromo ea tokollo, matšoao, overdose, litla-morao le li-analogues

Ntho ea bohlokoa, e sebetsang ke Diphenhydramine. Mochine oa ts'ebetso o ipapisitse le phello ea thibelo ea lithethefatsi mantlha, likarolo tsa cholinergic, le thibelo ea li-receptor tsa H3-histamine bokong. Diphenhydramine e imolla ho opeloa, ho ruruha ha mesifa, hyperemia, ho thibela mesifa ea mesifa e boreleli, e na le phello e ntle ho boteng ba capillary. Ho nka liforomo tsa molomo ho baka khatello ea kelello ea nako e khuts'oaneng ea molomo. Setlhare se na le litlamorao tsa antiparkinsonian, hypnotic, sedative, antiemetic. Ka lebaka la ho thibeloa ha li-cholinergic receptors, ganglia e fokotsa khatello ea mali, 'me e ka eketsa tse fumanehang hypotension. Bathong ba nang le lefu la ho akheha le ho senyeha ha boko ba lehae, le litekanyetso tse tlase tsa Diphenhydramine li ka baka lefu la sethoathoa, 'me ho EEG, ts'ebetso ea ts'oaetso ea lefu la sethoathoa e hlokomelehile. Setlhare se sebetsa haholo ho bronchospasmho halefisoa ke ts'ebeliso ea liberals tsa histamine (morphine, tubocurarine). Setlhare ha se na katleho bakeng sa bronchospasm ea allergic genesis. Ka tekanyetso e sa khaotseng, lipilisi tsa ho robala le litlamorao li theola haholoanyane. Setlhare se qala ho sebetsa ka hora e le ngoe kamora ho kenella, phello e sebetsang e nka lihora tse 12.

Sokolla foromo le sebopeho

Mefuta ea litekanyetso tsa diphenhydramine:

• Matlapa: a bosoeu, a pota-potile sebopeho sa cylindrical se nang le bevel (li-pcs tse 10. Ka har'a moqomo o mosesaane, ka lebokoseng la mekotla ea 1, 2, 3 kapa 5, li-pcs tse 10. ka mokotleng oa pampiri ea bezeljacheykovy 1, 2 kapa 3 liphutheloana, li-pcs tse 10. Kapa likhomphutha tse 20. Lijaneng tse nang le khalase tse lefifi, ka lebokoseng la karete e le ngoe ea 1,)
• Tharollo bakeng sa tsamaiso ea methapo (i / v) le tsamaiso ea methapo (i / m): metsi a sa bonahaleng a sa bonahaleng ka li-ampoules tsa 1 ml (li-pcs tse 5. Ka lipaketeng tse bloker, ka lebokoseng la karete ea 1 kapa 2, likhomphutha tse 10. Li-pcs tse 10, ka har'a mekotla ea lithutsoana, likhaketeng tse 2 tsa karete, likhomphutha tse 10. ka paketeng ea blister, ka pakete ea 1 ea karete.

• Matlapa: diphenhydramine hydrochloride, ho 1 pc. - 50 mg
• Tharollo: diphenhydramine, ho 1 ml - 10 mg.

• Matlapa: cellulose ea metsi a qhibilihang - 0,326 mg, lactose monohydrate (tsoekere ea lebese) - 75 mg, colloidal silicon dioxide (aerosil) - 0,76 mg, starch ea poone - 23.154 mg, stearic acid - 0,76 mg,
• Tharollo: metsi a ento.

Matšoao a ho sebelisoa

• Mekhoa ea ho kulisa, ho kenyelletsa hay fever, urticaria, angioedema,
• Hemorrhagic vasculitis,
• Allergic conjunctivitis,
• Ho kula ha Serum
• Chorea
• Vasomotor rhinitis,
• Itchy dermatoses,
• Mathata a ho robala, joaloka monotherapy kapa hammoho le lipilisi tsa ho robala,
• Ho imolla
• Ho foka hoa moea le ho feroha ha maoatle,
• Matšoao a Meniere,
• Pheko.

Contraindication

• Alcering ulcer ea duodenum le / kapa mpa,
• Lerotholi la bronchial,
• Angle-shutter glaucoma,
• Bladder molaleng stenosis,
• Hypertrophy ea tšoelesa ea senya
• Lefu la ho akheha
• Hypersensitivity ho diphenhydramine.

Ka tlhokomelo le matšoao a tiileng, diphenhydramine e beoa nakong ea kemolo le nakong ea kanyeso, ha feela moputso o lebelletsoeng ho mme o feta kotsi e ka ba teng ho lesea kapa lesea.

Tekanyetso le tsamaiso

• Matlapa: ho nkuoa ka molomo. Tekanyetso bakeng sa bakuli ba baholo: e le lipilisi tsa ho robala - 50 mg ka nako ea ho robala, kalafo - makhetlo a 30-50 mg makhetlo a 1-3 ka letsatsi, matsatsi a 10-15. Bakeng sa bana, tekanyetso e le 'ngoe ke: ho fihla ho selemo sa 1 - 2-5 mg, ho tloha ho lilemo tse 2 ho isa ho 5 - 5-15 mg, ho tloha ho lilemo tse 6 ho isa ho 12 - 15-30 mg,
• Tharollo bakeng sa tsamaiso ea methapo le methapo: bakeng sa bakuli ba baholo, ente ea intramuscular ka lethal dose ea 50 ho isa ho 250 mg, draina ea methapo - 20-50 mg. Ho khothalletsoa kantle makhetlo a 1-2 ka letsatsi.

Litlamorao

Tšebeliso ea diphenhydramine e ka baka litlamorao:

• Mohlomong: ho otsela, letsoalo le khuts'oane la mucosa ea molomo, ho fokotseha tlhokomelo, bofokoli bo akaretsang, baneng - nts'etsopele ea boroko ba ho hloka boroko, ho hlasimoloha le ho teneha,
• Haholo-holo: hlooho ea hlooho, ho tsekela, ho sitisoa ha ho sisinyeha, ho nyekeloa, molomo o omileng, fensetere ea mahlo, ho thothomela, sebaka sa bolulo.

Litaelo tse khethehileng

Mokuli nakong ea ts'ebeliso ea lithethefatsi o khothalletsoa ho qoba ho pepesehela mahlaseli a letsatsi, ho hlokahala hore a khaotse ho sebelisa joala.

Nakong ea kemaro le kanyeso, moriana o lokela ho sebelisoa tlasa tlhokomelo ea bongaka e haufi.

E laetsoe ka hloko ho bakuli ba amehang mefuteng e ka bang kotsi ea mosebetsi, ts'ebetsong ea eona e hlokang karabelo e potlakileng ea psychomotor le tlhokomelo e eketsehileng.

Ho sebelisana le lithethefatsi

Ts'ebeliso ea diphenhydramine e eketsa ts'ebetso ea lithethefatsi tse thibelang tsamaiso ea methapo e kholo, e ntlafatsa ts'ebetso ea ethanol.

Ho kopana le monoamine oxidase inhibitors (MAO) ho eketsa tšebetso ea anticholinergic ea lithethefatsi.

Boitšoaro ba ho hanyetsa bo hlaha khahlano le semelo sa kopano e kopanetsoeng le li-psychostimulants.

Tšebeliso e tšoanang ea lithethefatsi e fokotsa phello ea emetic ea apomorphine kalafong ea chefo.

Lithethefatsi li eketsa litlamorao tsa li-anticholinergic tsa lithethefatsi tsa anticholinergic.

Li-Analog tsa Diphenhydramine ke: Diphenhydramine-ROS, diphenhydramine-UBF, Diphenhydramine-UVI, Diphenhydramine-Vial, Diphenhydramine Bufus, Dramina, Kalmaben.

Diphenhydramine: litheko ho litlhare tsa marang-rang

DIMEDROL 50mg 10 likhomphutha. lipilisi

Diphenhydramine 50 mg matlapa a 10 li-pcs.

DIMEDROL 50mg 10 likhomphutha. lipilisi

DIMEDROL 50mg 20 likhomphutha. lipilisi

Diphenhydramine 50 mg matlapa a 20 likhomphutha.

Diphenhydramine 50mg No. 20

Diphenhydramine (bakeng sa ente) 10 mg / ml tharollo bakeng sa tsamaiso ea methapo le methapo 1 ml 10 li-pcs.

DIMEDROL 10mg / ml 1ml 10 likhomphutha. ente ea methapo

Diphenhydramine (bakeng sa ente) 10 mg / ml tharollo bakeng sa tsamaiso ea methapo le methapo 1 ml 10 li-pcs.

Diphenhydramine (bakeng sa ente) 10 mg / ml tharollo bakeng sa tsamaiso ea methapo le methapo 1 ml 10 li-pcs.

DIMEDROL 10mg / ml 1ml 10 likhomphutha. tharollo bakeng sa tsamaiso ea methapo le methapo

DIMEDROL 10mg / ml 1ml 10 likhomphutha. tharollo bakeng sa tsamaiso ea methapo le methapo

Tlhahisoleseling mabapi le lithethefatsi e akaretsoa ka kakaretso, e fanoa molemong oa tlhahisoleseling mme ha e nke sebaka sa litaelo tsa semmuso. Ho ikoetlisa ho kotsi bophelong!

Lefu le sa tloaelehang haholo ke lefu la Kuru. Ke baemeli ba morabe oa Fore New New New ba kulang le eena. Mokuli o shoa ka lebaka la litšeho. Ho lumeloa hore sesosa sa lefu lena se ja kelello ea motho.

Ho latela bo-rasaense ba bangata, li-vithamine tse ngata ha li na thuso bathong.

Moahi oa Australia ea lilemo li 74 ea bitsoang James Harrison o ile a fana ka mali makhetlo a ka bang sekete. O na le mofuta oa mali o sa tloaelehang, li-antibodies tsa ona tse thusang masea a sa tsoa tsoaloa a nang le anemia e matla hore a phele. Kahoo, Australia e ile ea pholosa bana ba ka bang limilione tse peli.

Motho e mong le e mong ha a na menoana e ikhethang feela, empa o na le puo.

Nakong ea bophelo, motho ea tloaelehileng ha a hlahise matamo a maholo a ka tlase ho a mabeli.

Linoko tse 'ne tsa chokolete e lefifi li na le likhalori tse ka bang makholo a mabeli. Kahoo haeba u sa batle ho phela hantle, ho molemo hore u se ke ua ja li-lobules tse fetang tse peli ka letsatsi.

Madi a motho "a" tsamaea "ka har'a lijana tlas'a khatello e kholo, mme haeba bots'epehi ba hae bo tlotsoe, bo ka thunya ho fihlela ho limithara tse 10.

Batho ba tloaetseng ho ja lijo tsa hoseng kamehla ha ba na monyetla oa ho ba motenya haholo.

Motho ea nkang khatello ea maikutlo maemong a mangata o tla boela a be le khatello ea maikutlo. Haeba motho a sebetsana le khatello ea maikutlo a le mong, o na le monyetla o mong le o mong oa ho lebala ka boemo bona ka ho sa feleng.

Ho latela liphuputso, basali ba noang likhalase tse 'maloa tsa biri kapa veine ka beke ba na le menyetla e eketsehileng ea ho tšoaroa ke mofetše.

Ntle le batho, ke ntho e le 'ngoe feela e phelang polaneteng ea Lefatše - lintja, e nang le bothata ba lefu la matsoele. Ka sebele tsena ke metsoalle ea rona e tšepahalang ka ho fetisisa.

Mocheso o phahameng ka ho fetisisa oa 'mele o tlalehiloe ho Willie Jones (USA), ea ileng a kenngoa sepetlele ka mocheso oa 46,5 ° C.

Ha re ntse re nyenyefatsa, 'mele oa rona o khaotsa ho sebetsa ka botlalo. Leha pelo e emisa.

Mosebetsi oo motho a sa o rateng o kotsi haholo ho psyche ea hae ho feta ho hloka mosebetsi ho hang.

Haeba u bososela habeli ka letsatsi, u ka fokotsa khatello ea mali le ho fokotsa kotsi ea ho tšoaroa ke pelo le stroke.

Ho haella ha karolo ea meno kapa esita le adentia e felletseng ho ka bakoa ke likotsi, lefu la "caries" kapa lefu la marenene. Leha ho le joalo, meno a lahlehileng a ka nkeloa sebaka ke meno.

Diphenhydramine ke eng

Ho latela sehlopha sa bongaka se amoheloang, Diphenhydramine ke ea li-blocker receptor blocker le lithethefatsi tse tlolang kalafo. Ntho e sebetsang ea sebopeho ke diphenhydramine hydrochloride, e sebetsang tsamaisong ea methapo e ka hare, e thibelang likarolo tsa histamine le cholinergic tse nang le li-receptor tsa boko. Ka lebaka la phello ena, mesifa ea mesifa e boreleli e tlosoa, ho na le phomolo ea boemo ba motho ka ho kulisoa.

Sebopeho le mofuta oa tokollo

Mefuta e ka sehloohong ea tokollo ea lithethefatsi ke tharollo ea ente le matlapa. Ea pele e ka nkuoa ka molomo kapa ea kenngoa ka mahlo. Ntle le moo, li-supplement tsa rectal li hlahisoa ho latela motsoako o sebetsang. Sebopeho le litlhaloso tsa litokisetso li bontšitsoe tafoleng:

White cylindrical e tšoeu e nang le likarolo le kotsi

Ts'oarello ea diphenhydramine, mg

30, 50 kapa 100 ka pc e le ngoe. / 20 bakeng sa bana

Metsi a hloekisitsoeng bakeng sa ente

Stearic acid, starch ea litapole, colloidal silicon dioxide, lactose

Ampoules ea 1 ml, li-pcs tse 10. ka paketeng e nang le litaelo tsa tšebeliso

Metsoako kapa marikhoe a 6 kapa 10 likhomphutha

Matla a lik'hemik'hale a 'mele a diphenhydramine

Lithethefatsi li amana le li-blockers tsa histamine receptors bokong. Ka lebaka lena, diphenhydramine e imolla mokokotlo oa mesifa e boreleli, e fokotsa ho pepeseha ha capillary, e fokolisa matla a methapo ea kutlo. Sebetsa se sebetsang sa tlhophiso ea anesthetic ea lehae se na le ts'ebetso ea antiemetic, matla a ho susumetsa, phello ea hypnotic.

Setlhare se baka anesthesia ea lehae, e iponahatsang ka mokhoa o makatsang oa ho tsebahala ha mucosa ea molomo, e nang le phello ea antispasmodic. Diphenhydramine e sebetsa hantle haholo haeba ho na le bronchospasm e hlahisoang ke histamine liberalizer (morphine), hanyane - maemong a mofuta oa allergic. Setlhare ha se na thuso khahlanong le asthma ea bronchial, se ka kopanngoa le bronchodilators (Theophylline, Ephedrine).

Diphenhydramine e loantšana le phello ea histamine, e eketsa khatello ea mali. Ho bakuli ba nang le khaello ea molumo oa mali, potoloho ea methapo ea methapo ea methapo e ka baka khatello ea mali le ho eketsa khatello ea mali ka lebaka la thibelo ea ganglion. Ka tšenyo ea sebakeng sa heno bokong, sethethefatsi se ka etsa hore lefu la sethoathoa le hlasele lefu la sethoathoa.

Setlhare se qala ho sebetsa ka metsotso e seng mekae, phello ea sona e nka lihora tse 12. Diphenhydramine e hokahana le liprotheine tsa plasma ka 98%, e kenngoa ka har'a sebete, mapheong le liphio, e pepesitsoe ke liphio, ka lebese la matsoele ka tsela ea li-metabolites tsa conjugate tse nang le glucuronic acid. Ntho e sebetsang ea motsoako e kenella ka har'a mokoallo oa mali, e leng palo ea mohlala feela e fumanoang lebeseng la matsoele.

Sehlopha sa Pharmacotherapeutic:

Khoutu ea ATX R06AA02

Ketso ea pharmacological
Blocker ea li-receptors tsa H1-histamine molokong oa pele. E thibela li-receptor tsa H1-histamine mme e tlosa litlamorao tsa histamine tse tsamaisitsoeng ka mofuta ona oa li-receptor. Ketso ea methapo e bohareng ea methapo ka lebaka la blockade ea N₃- histamine li-receptor tsa boko le thibelo ea likarolo tse bohareng tsa cholinergic. E na le ts'ebetso ea antihistamine e phatlalalitsoeng, e fokotsa kapa e thibela mesifa ea mesifa e boreleli ea histamine, e eketsa sekhahla sa boteng, ho ruruha ha mesifa, ho hlohlona le hyperemia. E baka anesthesia ea lehae (ha e nkuoa ka molomo, ho ba le letsoele le khuts'oane la mucous ea mokokotlo oa molomo), ho thibela ganglia cholinergic receptors (lower khatello ea mali) le tsamaiso ea methapo e kholo, mme e na le litlamorao, hypnotic, antiparkinsonia le antiemetic. Ho qhekella ka histamine ho bonahala ka tekanyo e kholo mabapi le ho fetoha hoa methapo ea methapo sebakeng sa ho ruruha le ho kulisa ho feta ho tse tsamaisoang, i.e. ho theola khatello ea mali. Ho batho ba nang le ts'oaetso ea kelello ea lehae le lefu la sethoathoa, e kenya tšebetsong (esita le litekanyetso tse tlase) e tsoa ho EEG mme e ka baka ts'oaro ea sethoathoa. Liphetho tsa Sedative le hypnotic li hlahisoa haholoanyane ka litekanyetso tse ngata.
Ho qala hoa ts'ebetso ho bonoa metsotso e 15-60 kamora ho kenella, nako ea lihora -12

Mofumahali
Ho kenella ka potlako pampiring ea mala. Bioavailability ke 50%. TCmax - 2040 min (khatello e phahameng ka ho fetisisa e hlahisoa mats'oafong, mokokotlong, liphio, sebete, bokong le mesifa). Puisano le liprotheine tsa plasma - 98-99%. E kenella ka har'a mokoallo oa mali le bokong. E tšelisoa haholo-holo ka har'a sebete, karolo e itseng mapheng le lipelong. E qotsitsoe linthong tsa ka mor'a lihora tse 6. halofo ea bophelo ke lihora tse 4-10. Mots'eare e qheleloa ka botlalo ke liphio ka mokhoa oa metabolites o kopaneng le glucuronic acid. Lichelete tse ngata li qheleloa ka lebeseng mme li ka baka phello e matla ho masea (karabelo e makatsang e bontšitsoeng ke thabo e feteletseng e ka bonoa).

Matšoao a ho sebelisoa
Allergic conjunctivitis, allergic rhinitis, urticaria e sa foleng, duratitis, dermatographism, lefu la serum, kalafong e rarahaneng ea karabelo ea anaphylactic, Quincke edema le maemo a mang a kulang.
Insomnia, chorea, lefu la Meniere, lefu la leoatle le moea, joalo ka antiemetic.

Contraindication
Hypersensitivity, angle-shutment glaucoma, hyperplasia ea masapo a sefahleho, ho ts'oaroa ke peptic ulcer ea mala le duodenum, stenosis ea molala oa senya, lefu la sethoathoa, lefu la sethoathoa.
Lilemo tsa bana ho fihlela lilemo tse 7 (bakeng sa foromo ena ea litekanyetso).

Ka tlhokomelo - boimana, ho nyeka.

Tekanyetso le tsamaiso
Ka hare. Batho ba baholo le bana ba kaholimo ho lilemo tse 14, 25-50 mg (1 / 2-1 Letlapa) makhetlo a 1-3 ka letsatsi. Tekanyetso e phahameng ka ho fetisisa ke 100 mg, letsatsi le letsatsi - 250 mg. Ka ho hloka boroko - 50 mg metsotso e 20-30 pele u robala. Ka ho kula ho sisinyehang - 25-50 mg ka mor'a lihora tse ling le tse ling tse 4 ho isa ho tse ling ha ho hlokahala
Bana ba lilemo li 7 ho isa ho 14 ba nang le lilemo tse 12,5 - 25 mg (1 / 4-1 / 2 litafole) makhetlo a 1-3 ka letsatsi.

Litla-morao
Ho otsela, molomo o omileng, letsoalo la mucosa ea molomo, ho tsekela, ho thothomela, ho nyekeloa ke hlooho, bofokoli bo akaretsang, boemo bo fokotsehileng ba karabelo ea psychomotor, photosensitivity, parresis ea bolulo, tšebelisano ea motsamao o sa sisinyeheng. Ho bana, kholo e makatsang ea ho hloka boroko, ho teneha le ho hlasimoloha ho ka etsahala.

Bongata
Matšoao khatello ea maikutlo ea methapo ea methapo e kholo, nts'etsopele ea nyakallo (haholo baneng) kapa khatello ea maikutlo, lipopa tse hlapollotsoeng, molomo o omileng, li-parresis tsa litho tsa methapo ea mpa, joalo joalo.
Phekolo: ha ho na litlhare tse khethehileng. Phokotso ea sefuba. Haeba ho hlokahala, kalafo ea matšoao: Lithethefatsi tse eketsang khatello ea mali, oksijene, tsamaiso ea methapo ea metsi a fetotsang plasma.
Se ke oa sebelisa epinephrine le analeptics.

Ho sebelisana le lithethefatsi tse ling
E ntlafatsa ts'ebetso ea ethanol le lithethefatsi tse thibelang tsamaiso ea methapo e bohareng.
Monoamine oxidase inhibitors e ntlafatsa mosebetsi oa anticholinergic oa diphenhydramine.
Ho sebelisana le ho phehisana ho hlokometsoe tumellano ea kopano le li-psychostimulants.
Fokotsa katleho ea apomorphine e le emetic ho phekola chefo.
E ntlafatsa litlamorao tsa li-anticholinergic tsa lithethefatsi tse nang le ts'ebetso ea anticholinergic.

Litaelo tse khethehileng
Ho hlokahala tlhokomeliso ho bakuli ba etsang lintho tse ka bang kotsi tse hlokang ho tsepamisa mohopolo le ho arabela ka potlako kelellong. Nakong ea kalafo ka diphenhydramine, ho pepesetsoa letsatsi le ethanol ho lokela ho qojoa.
Hoa hlokahala ho tsebisa ngaka ka tšebeliso ea moriana ona: litlamorao tsa antiemetic li ka thatafatsa ho hlahlojoa ha appendicitis le ho amoheloa ha matšoao a bosholu ba lithethefatsi tse ling.
Ho bana ho tloha ho selemo se le seng ho isa ho lilemo tse 7, ho khothalletsoa ho sebelisa matlapa a 30 mg (ho tloha ho selemo se le seng ho isa ho lilemo tse 3, tekanyetso ea letsatsi le letsatsi ea 10-30 mg, e arotsoe ka litekanyetso tse 2-3, ho tloha ho lilemo tse 4 ho isa ho tse 6, tekanyetso ea letsatsi le letsatsi ea 20 - 45 mg, e arotsoe ka 2) -3 ho amoheloa).
Ho bana ho tloha ho likhoeli tse 7 ho isa ho likhoeli tse 12, sethethefatsi se ka sebelisoa ka mokhoa oa phofo e lokiselitsoeng lingong tsa meriana le tsa tlhahiso ea li-pharmacies 3-5 mg makhetlo a 2-3 ka letsatsi.

Fomu ea tokollo
Matlapa a 50 mg
Ho matlapa a 10 sephutheloaneng se sa roaloang kapa ka sephutheloana. Ho lipakete tse 2, 3 kapa 5 tsa blister strip hammoho le taelo ea kopo li behiloe ka paketeng e tsoang ho letlapa.

Letsatsi la ho felloa ke nako
Lilemo tse 5 Se ke ua sebelisa lithethefatsi kamora letsatsi la ho felloa ke nako.

Maemo a polokelo
Lenane B. Sebakeng se ommeng, se lefifi le moo bana ba sa khoneng ho se fihlela.

Lipehelo tsa matsatsi a phomolo
Ka lengolo la ngaka.

Moetsi oa kopo / mokhatlo:
OJSC "Dalhifarm"
680001, Khabarovsk, st. Tashkent, 22.

Ketso ea pharmacological

E na le antihistamine, antigergic, antiemetic, hypnotic, anesthetic ea lehae. Lithibelo histamine H₁ - li-receptors le ho felisa litlamorao tsa histamine tse tsamaisitsoeng ka mofuta ona oa li-receptor. Fokotsa kapa ho thibela mekhahlelo ea mesifa e boreleli ea histamine, ho eketsa ho eketsoa hoa capillary, ho ruruha ha mesifa, pruritus le hyperemia. Ho qhekella ka histamine ho bonahala ka tekanyo e kholo mabapi le karabelo ea methapo ea lehae ha ho ka etsahala hore ho be le ho ruruha le ho kulisoa ke lintho tse tsamaellanang le tsona. ho theola khatello ea mali. E baka anesthesia ea lehae (ha e nkuoa ka molomo, ho ba le maikutlo a nakoana a letsoalo la mucosa ea molomo), e na le phello ea antispasmodic, 'me e thibela li-receptors tsa cholinergic tsa gangonomic ganglia (e theola khatello ea mali). Lithibelo N₃ - Li-receptor tsa histamine tsa boko mme li thibela likarolo tse bohareng tsa cholinergic. E na le tšusumetso, khatello ea kelello le antiemetic. E sebetsa haholoanyane bakeng sa bronchospasm e hlahisoang ke liberals tsa histamine (tubocurarine, morphine, sombrevin), ho isa tekanyong e fokolang ea bronchospasm. Le asthma, ha e sebetse 'me e sebelisoa hammoho le theophylline, ephedrine le li-bronchodilators tse ling.

Mofumahali

Ha e nkoa ka molomo, e kenella ka potlako ebile e tebile. E amana le liprotheine tsa plasma ka 98-99%. Tlhokahalo e phahameng (C_tlhokomeliso) ho plasma e fihlella lihora tse 1-4 kamora ho kenella. Boholo ba diphenhydramine e nkuoeng e tšeloa ka har'a sebete. Half-life (T_1/2) ke lihora tse 1-4. E ajoa hohle 'meleng, e feta methapong ea mali le bokong ba mali. E entsoe ka lebese mme e ka baka ts'oaro ho masea. Motšehare, e pepesetsoa ka botlalo ho tsoa 'meleng haholo ka sebopeho sa benzhydrol e kopaneng le glucuronic acid, mme e le ka tekanyo e nyane feela - e sa fetoheng. Phello e phahameng e hlaha hora e 1 kamora ho kenella, nako ea ketso e nka lihora tse 4 ho isa ho tse 6.

Litla-morao

Ho tsoa ho tsamaiso ea methapo ea kutlo le litho tsa kutlo: ho fokola ka kakaretso, mokhathala, ho ferekanya kelello, ho fokotsa tlhokomelo, ho tsekela, ho otsela, ho opeloa ke hlooho, ho imeloa hantle ha motsamao, ho tšoenyeha, ho teneha ho hoholo (haholoholo baneng), ho hloka botsitso, ho hloka boroko, ho hloka boroko, ho hlonama, pherekano. , ho thothomela, ho ruruha, ho tsitsipana, ho ruruha ha mahlo, ho senyeha ha pono, diplopia, labyrinthitis e matla, tinnitus. Ho bakuli ba nang le ts'oaetso ea boko ba lehae kapa lefu la sethoathoa, e sebetsa (esita le ka tekanyetso e tlase) e tsoa ho EEG mme e ka tsosa moferefere.

Ho tsoa ho tsamaiso ea pelo le mali: hypotension, palpitations, tachycardia, extrasystole, agranulocytosis, thrombocytopenia, hemolytic anemia.

Ho tsoa ho tšilo ea lijo: molomo o omileng, ho omella ka nako e khuts'oane ea mucosa ea molomo, ho nyekeloa ke pelo, ho nyekeloa ke pelo, ho sithabela ha epigastric, ho hlatsa, lets'ollo, ho sokela.

Ho tsoa ts'ebetsong ea genitourinary: khafetsa le / kapa ho ntša ho thata, ho boloka urine, ho ilela khoeli pele.

Karolong ea sistimi ea ho hema: nko e omeletseng le 'metso, tšubuhlellano ea nko, ho totobala secretion ea bronchial, ho tiisa sefubeng le ho hema hanyane.

Boitšoaro bo kulisang: ho potlaka, urticaria, ho makala ha anaphylactic.

Tse ling: ho fufuleloa, ho hlatsa, ho hlasimolla mahlo.

Bongata

Matšoao: Ho omella molomo, ho hema ka thata, ho phethesela sefahleho, ho tepella maikutlong kapa ho ferekana (hangata ho bana) ho tsamaiso ea methapo ea kutlo, pherekano ho bana - nts'etsopele ea ho ts'oaroa le lefu.

Phekolo: Ho kenoetsa ho hlatsa, ho hlatsa ka mpeng, ho tsamaisa makala a makhopho a nang le ts'oaetso, matšoao le a tšehetsang ka ho lekola phefumoloho le khatello ea mali hantle.

Ka lipilisi

Bakeng sa batho ba baholo, matlapa a Diphenhydramine a nooa ka tekanyo ea 30-50 mg makhetlo a 1-3 / letsatsi ka nako ea matsatsi a 10-15. Tekanyetso e le 'ngoe bakeng sa bana ba ka tlase ho lilemo tse 2-5 mg, ngoana ea lilemo li 2-5 o lokela ho amohela 5-5 mg, lilemo tse 6-12 - 15-30 mg. Diphenhydramine e sebelisoa e le pilisi ea ho robala 50 mg ka nako ea ho robala. Ho thata ho feta tekanyetso e boletsoeng ke ngaka ka lebaka la menyetla e eketsehang ea menyetla ea karabelo e mpe. Matlapa a hlatsuoa ka metsi, a nkuoa ho sa tsotelehe lijo.

Tlas'a lebitso "diphenhydramine" li-supplement ha li fumanehe, empa ho na le li-supplement tsa ts'ebeliso ea rectal tse nang le analgin le diphenhydramine, ka mohlala, Analdim. Li sebelisoa e le sehlahisoa se thethefatsang kamora enema ea ho itlhoekisa, e kenngoeng kahare ho rectum habeli / ka letsatsi. Bana ba lilemo li 1-4 ba behiloe lengolo le le leng la tlatsetso, ba baholo - li-supplement. Ha motho a le monyane lilemong, o lokela ho kenya tšebetsong lintho tse sebetsang. Tsela ea kalafo e nka matsatsi a 1-4.

Bakeng sa ts'ebeliso ea ophthalmology kapa allergology, marotholi a diphenhydramine a laetsoe. Bakeng sa sena, 0,2-0,5% ka tharollo ea 2% ea boric acid e kenngoa ka makhetlo a 1-2 e theoha makhetlo a 3-5 / ka letsatsi ho kopanya se kopane. Tharollo e ka tsamaisoa ka mokhoa o sa tsitsang, ho felisa matšoao a lefu la ho kula le lefu la ho ferekana kelellong - 0,05 ml ea moriana ka nostril e 'ngoe le e' ngoe ka makhetlo a mangata / ka letsatsi. Tlhahlobo ea kalafo e khethoa ke ngaka e eang, o boetse a fana ka litlhare tse nepahetseng tsa moriana.

Diphenhydramine nakong ea kemolo

Lingaka li beha moriana ona ka hloko nakong ea kemaro le ho lactation, hobane diphenhydramine e ka baka litlamorao tse mpe tsa kholo ea ngoana. Pele o nka ngaka o lokela ho lekola melemo ho mme ho feta kotsi e ka hlahang ka popelong, mme haeba e phahame, fana ka moriana. Ka ho anyesa, diphenhydramine e fetela ka lebeseng la matsoele, e ka baka phello e susumetsang matsatsing a masea kapa ho thatafala ho eketsehileng. Ka mkeno, moriana o kopantsoe.

Diphenhydramine ea bana

U ke ke ua sebelisa Diphenhydramine bakeng sa bana ntle le keletso ea ngaka mme u nahane ka nyeoe ka 'ngoe, fumana ho teba ha lefu lena le lipontšo tsa tšebeliso. Ts'ebeliso ea tharollo bakeng sa tsamaiso ea batsoali le liente e tšoaetsitsoe a le lilemo li ka bang ho isa ho likhoeli tse supileng, matlapa a tsamaiso ea molomo - ho fihlela lilemo tse tšeletseng. Sheba litekanyetso tsa ngoana ka hloko ho qoba kotsi ea litla-morao tse mpe le ho tsosa takatso e matla haholo.

Ho tsamaisana le joala

Ho latela lipatlisiso, moriana o ntlafatsa phello ea inanthic ea ethanol ho tsamaiso ea methapo ea kutlo, ka hona meriana eohle ea joala le lino tse nang le joala kapa lithethefatsi li lokela ho lahloa ka nako eohle nakong ea kalafo ea meriana. Ho kopana ha sethethefatsi sena le joala hampe ho ama sebete, ho etsa hore menyetla ea ts'ebeliso e ngata ea lithethefatsi e be chefo ke metabolites ea joala.

Lipehelo tsa thekiso le polokelo

Moriana o fanoa ka taelo ea ngaka, e bolokiloeng hole le bana sebakeng se lefifi ka mocheso o sa feteng 30 degrees bakeng sa lilemo tse hlano.

Ho na le mefuta e 'maloa ea li-analogues tsa moriana o nang le ntho e le' ngoe e sebetsang. Hape ha ho rekisoa ho na le lithethefatsi tse nkang likarolo tse ling, empa ka phello e tšoanang 'meleng. Meriana e tsebahalang:

• Diphenhydramine chloride,
• Diphenhydramine,
• Allergan,
• Diphenyl
• Lekola botjha
• Alledril
• Diabenil

U tla khona ho reka lengolo le fanoang litlolong tsa litlhare kapa mabenkeleng a marang-rang. Litsenyehelo tsa moriana li its'etleha ka mofuta (matlapa / tharollo), moeli oa khoebo le mohopolo oa ntho e sebetsang. Litheko tsa lithethefatsi tsa litlama tsa bophelo bo botle tsa meriana li hlahisoa ka har'a tafole:

Ampoules 1 ml 10 li-PC.

Matlapa a 50 mg 10 likhomphutha.

Veronika, ea lilemo li 28. Ke tšoeroe ke lefu la ho hlobaela, ke sa khone ho robala, ho akheha le ho tjeka nako e telele, hoseng ho latelang ke tsohile ke robehile. Sena se ama hampe bokhoni ba ho sebetsa. Motsoalle o ile a nkopa hore ke noe Tafhenhydramine Tablet bosiu makhetlo a 'maloa ka beke. Ke ile ka mamela, 'me ka khotsofala. Setlhare sena ka bonolo, ha se bake ho nyekeloa le "liphoso" tse matla maemong a boroko.

Leonid ea lilemo li 38. Selemo se seng le se seng ke qala ho tetebela le ho khohlela, hobane lipalesa li thunya, lifate li thunya. Ke na le allergy, ke Drops of diphenhydramine feela e khonang ho sebetsana le eona. Ke li epela mahlong a ka hore ke imolohe ho ruruha le ho rusolla, ka linako tse ling ke ee ke inamise nko ea ka hore ke felise nko e tsamaeang. Setlhare se hantle, 'me ha se theko e tlase, eseng joaloka mekhoa ea sejoale-joale.

Elizabeth, ea lilemo li 32. Khoeling e fetileng ke ile ka tobana le lefu la masapo le hlohlotsang. Mosebetsi o amahanngoa le lik'hemik'hale tsa lapeng, 'me' mele o arabetse. Ka nako e telele ke ne ke batla pheko e ka thusang, qetellong ke ile ka lula matlapeng a Diphenhydramine. Ke li noe bosiu, hobane moriana o baka ho otsela mots'eare, mme le nna ke fafatsa matheba ka tranelate. Ho na le katleho, empa eseng ka lebelo joalo ka ha ke ne ke batla.

Vitaliy, ea lilemo li 41. Ka lekhetlo la pele khoeli le halofo e fetileng, ke ne ke tobane le bothata ba ho ba leoatleng, 'me ke ile ka qala ho kula ka koloing. Ke ile ka utloa hore Diphenhydramine e sebetsana hantle le matšoao a bokuli, ka etsa qeto ea ho etsa thupelo. Setlhare se se se felile - se etsa hore u robale, ka hona ha re bue ka ho khanna. Ke tla batla mofuta oa sejoale-joale sa Diphenhydramine ho khanna koloi.

Letlapa la diphenhydramine, litaelo tsa tšebeliso

30-50 mg e le 'ngoe ho isa ho makhetlo a mararo ka letsatsi, nako ea phekolo ke matsatsi a 10-15.

Ka ho hloka boroko 50 mg e behiloe halofo ea hora pele a robala.

Ho postencephalic, idiopathic parkinsonism qalong a nehelloa 25 mg makhetlo a mararo ka letsatsi, ka tekanyetso e latelang a eketseha hanyane ka hanyane ho isa ho 50 mg makhetlo a 4 ka letsatsi.

Ka bokuli ba ho sisinyeha lihora tse ling le tse ling tse 6 u hloka ho nka litafole tse 25-50 mg.

Tšebelisano

Diphenhydramine e ntlafatsa ketso ea lithethefatsi tse thibelang tsamaiso ea methapo. Ha e kopantsoe le psychostimulants phello ea ho hanyetsa e tlalehiloe. MAO inhibitors eketsa mesebetsi ea anticholinergic ea lithethefatsi. Ha ho phekoloa chefo, tahi, lithethefatsi li fokotsa katleho apomorphine.

Diphenhydramine le joala

Ho entsoe lithethefatsi ka joala. Matla a joala a ntlafatsoa, ​​phello ea hypnotic ea eketseha, tšenyo e kholo 'meleng ea khoneha. Phello e ke ke ea boleloa esale pele, haholo-holo ha u sebelisa tekanyetso e kholo. Vodka e nang le diphenhydramine e kanna ea ba seno sa ho qetela bophelong ba motho ea jeleng motsoako ona, lethal dose e bolaeang e ka ba nyane haholo ha e kopantsoe le joala.