Rosart: litaelo tsa tšebeliso, matšoao, litlhahlobo le li-analogues

Babali ba rona ba sebelisitse Aterol ka katleho ho theola cholesterol. Ha re bona sehlahisoa sena se tsebahala, re nkile qeto ea ho e ela hloko.

Rosart - sethethefatsi se amanang le li-statins, se sebelisetsoang ho theola cholesterol ea mali. Rosart ea lithethefatsi e le motsoako o sebetsang o na le rosuvastatin. Setlhare sena se fumaneha ka mofuta oa matlapa a 5, 10, 20 le 40 mg ka sebopeho sa Actavis Group ho la Iceland. Rosart e sebelisoa haholo ho phekola hypercholisterinemia.

• Matšoao a ts'ebeliso ea lithethefatsi
• Phekolo ea lijo le phepo ea methapo
• Melao ea ho khetha ea Rosart
• Ha ke na Sebelisa Rosart Neng?
• Ho ima le ho fepa ngoana
• Sebelisa Rosart ka hloko
• Lintho tse fapaneng tse tla etsahala
• Menahano ea lithethefatsi

Rosart e na le thepa e latelang ea pharmacological:

• fokotsa cholesterol - lipoprotein tse tlaase,
• ho theola boemo ba cholesterol A - lipoprotein tse tlaase haholo,
• ho theola cholesterol e felletseng le triglyceride maling,
• ho fokotsa k'holeseterole - liprotein tse phahameng haholo,
• e theola likarolo tse fapaneng tsa cholesterol - lipoprotein tse phahameng le tse tlase,
• e ama boemo ba alipoproteins A le B.

Phello ea hypolipidemic ea Rosart ka kotloloho e latela litekanyetso li sebelisoa. Kamora ho qala ha kalafo ea Rosart, phello ea kalafo e hlaha kamora beke e le 'ngoe, kamora libeke tse peli e fihla ho 90%, mme kamora libeke tse' ne tsa tšebeliso e phahameng ea pharmacological e fihlelletse mme e sala e le boemong bona. Setlhare se kenella ka har'a tšilo ea lijo, se tšeloa ka har'a sebete 'me se tšeloa ka mpeng ho ea lipakeng, le ho isa liphoofolong tse tlase.

Ke eng se thusang Rosart?

Rosart, setšoantšo sa matlapa

Matšoao a ts'ebeliso ea lithethefatsi ke a latelang:

• hypercholesterolemia ea mantlha kapa hyperlipoproteinemia,
• hereditary hypercholesterolemia, e sa phekoloeng kalafo ea ho ja le mekhoa e meng eo e seng ea lithethefatsi,
• bongata ba li-triglycerides,
• molemong oa ho fokotsa tsoelo-pele ea atherosulinosis,
• e le thibelo ea mantlha ea mathata a tloaelehileng a mafu a pelo (stroke, ho nyekeloa ke pelo, ischemia).

Sokolla foromo le sebopeho

Rosart e fumaneha ka mofuta oa matlapa a koahetsoeng ka filimi: biconvex, ka lehlakoreng le leng e ngotsoe "ST 1" matlapeng a masoeu a pota-potileng, "ST 2" le "ST 3" matlapeng a pinki a pinki, "ST 4" ho matlapa a nang le sebopeho sa oval e pinki (ka har'a lithutsoana: li-pcs tse 7., lebokoseng likhakete tse 4, lilakane tse 10, likhaketeng tse tharo kapa tse 9 tsa lilakane, likhaketeng tse 14.

Letlapa le le leng le na le:

• ntho e sebetsang: khalsiamo ea rosuvastatin - 5.21 mg, 10.42 mg, 20.84 mg kapa 41.68 mg, sena se lekana le litaba tsa 5 mg, 10 mg, 20 mg kapa 40 mg tsa rosuvastatin, ka ho latellana,
• likarolo tse thusang: lactose monohydrate, microcrystalline cellulose (mofuta oa 102), calcium hydrogen phosphate dihydrate, crospovidone (mofuta A), magnesium stearate,
• sebopeho sa koae ea lifilimi: matlapa a masoeu - Opadri tšoeu II 33G28435 (titanium dioxide, hypromellose-2910, lactose monohydrate, triacetin, macrogol-3350), matlapa a pinki - Opadra pink II 33G240007 (titanium dioxide, hypromellose-2910, lactose monohydrate, triacetin , macrogol-3350, dae carmine e khubelu).

Litaelo tsa ho sebelisa Rosart, litekanyetso

Rosart e ka nooa nako efe kapa efe ea letsatsi, ho sa tsotelehe lijo. Ho bohlokoa ho mokuli nakong ea kalafo ho latela lijo tse thata, tseo moelelo oa tsona e leng karohano ea lijo tse mafura.

Litekanyetso li khethoa ka mokhoa o ikhethileng 'me ho latela lintlha tse kang lipalo tsa laboratori tsa boemo ba cholesterol, boteng ba methapo ea pelo le mafu a ka mpeng.

Qalong ea thupelo ea kalafo, litekanyetso tse nepahetseng tsa letsatsi le letsatsi ke 5 kapa 10 mg. Teko ea kalafo e etsoa libeke tse 'ne hamorao: haeba boemo ba "cholesterol" e ntle ha bo so lekane, palo ea lithethefatsi e nyolohela ho 20 mg, mme haeba ho hlokahala, ho 40 mg.

Haeba mokuli a nka tekanyetso e lekaneng e amohelehang, joale o hloka ho hlahlojoa khafetsa hobane ho na le kotsi e kholo ea ho ba le karabelo e mpe.

Litaelo tsa ho sebelisoa ha Rosart li hohela ka ho khetheha litšebelisano tsa lithethefatsi le lithethefatsi tse ling:

1. Haeba mokuli a sebelisa moemeli oa immunosuppress Cyclosporine, joale lethal dose e khothalletsoang ea Rosart ke 5 mg.

2. Sethethefatsi Hemofibrozil se na le litlamorao tse tšoanang le tsa ramatiki le Rosar, kahoo lithethefatsi ka bobeli li lokela ho nooa bonyane kapa tekanyo e bohareng.

3. Protease inhibitors (lithibela-mafu tse thibelang likokoana-hloko tse fuoeng vaerase ea ho itšireletsa mafung, lithethefatsi - Agenerase, Crixivan, Virasept, Aptivus) li thibela enzyme e ikarabellang bakeng sa ho phatloha ha li-polyprotein. Kahoo, haeba mokuli a nka Rosart ka kalafo ena, joale katleho ea eona e eketseha makhetlo a mararo. Tabeng ena, litekanyetso tse phahameng tsa moemeli ea fokotsang lipid ha ea lokela ho ba 10 mg.

Moriana o lokela ho hlatsuoa ka metsi a lekaneng, matlapa a hlafunoang ha a khothalletsoe.

Contraindication le overdose

Ka tšenyo e matla ea liphio, lefu le mafolofolo la sebete le mesifa dystrophy, matlapa ha a laeloa. Rosart ha e khothalletsoe basali ba rerileng ho ima.

Lintho tse ling tse hanyetsanang - nako eohle ea boimana, ho anyesa (lesea) le bana ba ka tlase ho lilemo tse 18.

Tekanyetso e phahameng ha e khethoe haeba mokuli a tšoeroe ke hypothyroidism (ho haella ha lihormone tsa qoqotho) kapa a sebelisa lino tse tahang (boemong bona, ho khothalletsoa tekanyo e bonolo ea lithethefatsi kapa lithethefatsi ha li laetsoe ho hang). Matlapa a fanoa ka hloko ho bakuli bao e mong oa bona a nang le bothata ba ho senyeha ha mesifa ea dystrophic. Bakeng sa batho ba morabe oa Mongoloid, meriana ena e laetsoe ka mokhoa o hlakileng tekanyong e fokolang.

Maemong a mang, ho nwa moriana ho ka baka karabelo tse latelang tse mpe:

• lipontšo tsa mziba ka tsela ea bofubelu ba letlalo, leqeba le lenyane, ho hlohlona,
• ho tsekela, ho opeloa ke hlooho, ho fokola mesifa,
• Tlolo ea ts'ebetso ea endocrine, e bonts'itsoeng nts'etsopele ea lefu la tsoekere la mofuta oa 1,
• ho tepella le ho tepella kapele,
• khatello ea mali e phahameng, palpitations.

Mokuli ha a khothalletsoe hore a lokise lethal dose ka holimo. Ho seng joalo, ho ka hlaha matšoao a ho feta tekano:

• ho nyekeloa, ho hlatsa, litulo tse otlolohileng,
• bohloko ba ka mpeng
• letšoele la letlalo, ho akheha,
• tlolo ea ho hema le ho otla ha pelo.

Haeba maemo ana a hlaha, tlhokomelo e potlakileng e lokela ho khothaletsoa ka potlako, le pele ho fihla ha lingaka, ho hlapolla mpa ea mokuli.

Mofumahali

Rosart ke lithethefatsi ho tsoa sehlopheng sa li-statin tse nang le ts'ebetso ea ho fokotsa lipid. Motsoako oa eona o sebetsang, rosuvastatin, ke inhibitor e ikhethileng ea 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), enzyme e fetolang HMG-CoA ho mevalonate, selelekela sa cholesterol.

Ka ho eketsa palo ea li-receptor tse fokolang tsa "density lipoprotein" (LDL) holim'a hepatocytes, rosuvastatin e ntlafatsa ho ts'oaroa le ho ts'oaroa ha LDL, e thibela ts'ebetso ea lipoprotein tse tlase haholo (VLDL) mme e fokotsa palo eohle ea LDL le VLDL. E theola maemo a phahameng a cholesterol ea LDL, cholesterol e felletseng, triglycerides (TG), cholesterol ea VLDL, TG-VLDL, cholesterol e se nang HDL (high density lipoproteins), apolipoprotein B (ApoV). Ho baka keketseho ea khoholeho ea cholesterol ea HDL le ApoA-I. E fokotsa sekhahla sa cholesterol-LDL ho cholesterol-HDL, cholesterol e felletseng ho cholesterol-HDL, cholesterol eo eseng HDL ho cholesterol ea HDL, apolipoprotein B (ApoB) ho apolipoprotein A-I (ApoA-I).

Phello ea hypolipidemic ea Rosart e itšetlehile ka kotloloho ho tekanyo ea tekanyo e boletsoeng. Phello ea kalafo e etsahala kamora beke ea pele ea kalafo, kamora libeke tse peli e fihla ho 90% ea phello e kholo, mme ka beke ea bone - 100% mme e lula e le joalo. Rosuvastatin e bontšoa bakeng sa kalafo ea hypercholesterolemia ntle le / ka hypertriglyceridemia, ho sa tsotelehe bong, lilemo kapa morabe oa mokuli, ho kenyelletsa bakuli ba nang le lefu la tsoekere le lefu la sethoathoa. Liphetho tsa lithuto li bonts'a hore ha a ntse a nka Rosart ka tekanyetso ea 10 mg ea mofuta oa IIa le IIb hypercholesterolemia (classrick ea Fredrickson) ka karolelano ea matla ea LDL cholesterol ea 4,8 mmol / L, LDL cholesterol mahloriso e fihlella litekanyetso tse ka tlase ho 3 mmol / L ho 80 % ea bakuli. Ka hypercholesterolemia ea homozygous ea lelapa, ho theoha ka sekhahla ha litekanyetso tsa cholesterol ea LDL ka rosuvastatin ka tekanyo ea 20 mg le 40 mg ke 22%.

Phello ea tlatsetso ho kopantsoeng ha Rosart le nicotinic acid ka lethal la 1000 mg kapa ho feta ka letsatsi (mabapi le keketseho ea cholesterol ea HDL) le fenofibrate (ha e bapisoa le ho fokotseha ha mahloriso ea TG) e boletsoe.

Mofumahali

Kamora ho sebelisa pilisi ea C_max (boholo ba mahloriso) ea rosuvastatin ho plasma ea mali e fihlelloa kamora lihora tse ka bang 5. Ts'ebetso ea eona ea ts'ebetso e eketseha ka tekanyo ea tekanyo e nkuoeng. Boaoavailability e felletseng e ka ba 20%. Litekanyetso tsa letsatsi le letsatsi tsa pharmacokinetic ha li fetoloe.

Ho tlama liprotheine tsa plasma ea mali (ho isa bo boholo le albin) ke hoo e ka bang 90%. Ho monya pelehi ho etsahala letsohong. V_d (bophahamo ba modumo) - 134 l. Setlhare se hlola bothata ba tlhaho.

Ke karoloana eo e seng ea mantlha ea li-isoenzymes tsa sisteme ea cytochrome P₄₅₀. Hoo e ka bang 10% ea rosuvastatin e biotransformed bokong. Ts'ebetso ea ho ts'oaroa ha rosuvastatin ho sebete e etsahala ka ho nka karolo ha mokelikeli o ikhethang oa semous - polypeptide, e fetisang "organic anion" (OATP) 1B1 mme e nka karolo ea bohlokoa ho feliseng hoa eona ea hepatic. Isoenzyme CYP2C9 ke isoenzyme ea mantlha ea metabolism ea rosuvastatin, ho isa tekanyong e tlase ea CYP3A4, CYP2C19 le CYP2D6.

Li-metabolites tse ka sehloohong tsa rosuvastatin ke li-metabolites tsa lactone tse sa sebetseng le N-desmethyl, e batlang e sa sebetse ka 50% ho feta rosuvastatin. Thibelo ea ho potoloha HMG-CoA reductase e netefatsoa ke ts'ebetso ea meriana le rosuvastatin tse fetang 90%

10% - ketsahalo ea metabolites ea eona.

Ka sebopeho se sa fetoheng, hoo e ka bang 90% ea lethal dose ea Rosart e tšeloa ka mpeng, ebe e setseng ka liphio. T_1/2 (halofo ea bophelo) - lihora tse ka bang 19, ka keketseho ea tekanyetso ea moriana, ha o fetohe. Karolelano ea Plasma clearance 50 l / h.

Ka botebo le bo itekanetseng ba ho se sebetse hantle ha phepo, phetoho e kholo maemong a mahloriso a rosuvastatin ho plasma ea mali kapa N-desmethyl ha e etsahale. Ho hloleha ho matla ha renal ka tumello ea creatinine clearance (CC) ea ka tlase ho 30 ml / min, litaba tsa rosuvastatin ho plasma li eketseha makhetlo a 3, N-desmethyl - makhetlo a 9. Ho bakuli ba nang le hemodialysis, khatello ea rosuvastatin ho plasma e eketseha ka hoo e ka bang 1/2.

Mehatong e fapaneng ea ho hloleha ha sebete (lintlha tse 7 le ka tlase ho Ngoana - sekhahla sa Pugh), keketseho ea T_1/2 ha e khetholloe. Elongation T_1/2 rosuvastatin e bonoa makhetlo a mabeli ho bakuli ba nang le ho se sebetse ha sebete ho lintlha tse 8 le 9 seketeng sa bana. Ha ho na le ts'ebetso e eketsehileng e holofatsang ea sebete, ha ho na boiphihlelo ka ts'ebeliso ea moriana.

Li-pharmacokinetics tsa rosuvastatin ha li na tšusumetso e kholo litabeng tsa bong le lilemo tsa mokuli.

Kamano ea morabe e ama likarolo tsa ramatiki ea Rosart. Plasma AUC (mahloriso a felletseng) a rosuvastatin ka Sechaena le Sejapane a phahame makhetlo a mabeli ho feta a batho ba Europe le Amerika Leboea. C_max le AUC ho Maindia le baemeli ba peiso ea Mongoloid ka karolelano e eketseha ka makhetlo a 1,3.

Matšoao a ho sebelisoa

• hypertriglyceridemia (mofuta oa IV ho ea ka Fredrickson) - e le tlatsetso ea lijo,
• hypercholesterolemia ea mantlha (mofuta oa IIa ho ea ka Fredrickson), ho kenyeletsa heterozygous hereditary hypercholesterolemia, kapa e kopaneng (e kopantsoeng) hyperlipidemia (mofuta IIb ho ea ka Fredrickson) - e le tlatsetso ea lijo, ho ikoetlisa 'meleng le ho theola boima ba' mele,
• mofuta oa homozygous oa lefu la lefu la sethoathoa ka ho se be le phello e lekaneng ea lijo le mefuta e meng ea kalafo e reretsoeng ho theola boemo ba mahloriso ba lipid (ho kenyeletsa le LDL apheresis) kapa ho se mamellane ka mefuta ea mofuta o joalo oa kalafo.
• Thibelo ea mantlha ea mathata a pelo (lefu la pelo, ho otloa, ho hlaseloa ha methapo) ho batho ba baholo ba se nang matšoao a lefu la pelo (CHD), empa ka litabatabelo tsa nts'etsopele ea bona (lilemo tsa banna ba baholo ho feta lilemo tse 50 le bakeng sa basali ba lilemo tse fetang 60, mahloriso C - protheine e sebetsang ea 2 mg / l le e phahameng ha e le teng bonyane ba lintlha tse tlatsetsang: kotsi ea khatello ea mali, cholesterol e tlase ea HDL, ho qaleha ha lefu la pelo la sethoathoa nalaneng ea lelapa, ho tsuba).

Ntle le moo, Rosart e khethoa e le tlatsetso ea lijo ho bakuli ba bonts'ang phekolo ea ho fokotsa cholesterol e felletseng le LDL cholesterol e le ho fokotsa tsoelo-pele ea atherosclerosis.

Li-analog tsa Rosart, lenane la lithethefatsi

Setlhare sa antissteotic se na le li-analogu tse ngata tse nang le thepa e tšoanang ea pharmacological. Leha ho le joalo, ha e khothalletsoe ho nkela sethethefatsi se seng sebakeng se seng ka se seng (mohlala, ka lebaka la phapang ea theko). Sena se ka lebisa taba ea hore sesebelisoa se khethiloeng sa bongaka se ka ba le phello e mpe 'meleng, se bontša litla-morao kapa se se na phello e nepahetseng ea kalafo.

Litšoantšo tse tšoanang tsa Rosart:

1. Akorta. Sena ke moemeli ea fokotsang lipid se etsang hore ho be le keketseho ea palo ea li-receptor tse fokolang tsa methapo ea methapo ea methapo ea methapo ea methapo, tse lebisang ho fokotseheng hoa khatello ea cholesterol e kotsi.
2. Crestor. Matlapa a boetse a bonts'a phello ea tsona ka har'a sebete (ho na le ho phatloha ha metabolic ea lipoprotein tse fokolang ka ho etsoa ha cholesterol). Keketseho ea palo ea li-receptor tsa hepatic ho li-membrane tsa lisele e baka ho eketseha ha catabolism le ho ts'oaroa ha lipoprotein tse tlase.

Hape li-analogues li kenyelletsa lithethefatsi - Rosucard, Rosistark, Tevastor.

Bohlokoa - Litaelo tsa Rosart bakeng sa tšebeliso, theko le litekanyetso ha li sebetse ho li-analogues 'me li ke ke tsa sebelisoa e le tataiso bakeng sa tšebeliso ea lithethefatsi tsa sebopeho kapa phello e tšoanang. Litefiso tsohle tsa kalafo li lokela ho etsoa ke ngaka. Ha u khutlisa Rosart ka analogue, ho bohlokoa ho fumana boeletsi ba setsebi; ho ka hlokahala hore u fetole mokhoa oa phekolo, litekanyetso, joalo-joalo.

Litlhahlobo tsa lingaka mabapi le Rosart li tsoakane. Bakeng sa lintlha tse ntle, phello e ntle le e tšoarellang ea kalafo e hlahang ka nako e khuts'oane ea nako e ka bonoa. Ka lehlakoreng le leng, ho ka ba thata ho khetha hore na o nooa hakae. Bakuli ba boetse ba na le tšitiso nakong ea kalafo, kaha ba tlameha ho tlohela lijana tse monate, tse tloaelehileng leha li le ngata haholo.

Litlamorao

Litlamorao ha li na seoelo. Litlamorao tse latelang li lokela ho tlaleheloa ngaka ea hau haeba li phehella kapa li mpefala:

Litlamorao tse latelang li mpe haholo. Haeba e fumaneha, o lokela ho khaotsa ho nka Rosart mme o botse ngaka hang-hang. Boitšoaro bo fosahetseng bo kenyelletsa:

• bohloko ba mesifa kapa bofokoli
• feberu,
• bohloko ba sefuba
• 'mala o mosehla oa letlalo kapa mahlo,
• moroto o lefifi
• bohloko bo ka mpeng bo ka holimo ba mpa,
• ho nyekeloa
• mokhathala o feteletseng
• ho tsoa mali ka mokhoa o sa tloaelehang kapa ho tsoa likotsi
• tahlehelo ea takatso ea lijo
• matšoao a kang a ntaramane,
• 'metso, bohloko kapa matšoao a tšoaetso.

Haeba matšoao a ho kula a hlaha, o lokela ho ikopanya le basebetsi ba bongaka ba tšohanyetso hanghang:

• makhopho
• urticaria,
• ho hlohlona,
• ho hema ka thata kapa ho koenya,
• ho ruruha sefahleho, 'metso, leleme, molomo, mahlo, matsoho, maoto, maqaqailana kapa maoto a tlase,
• hoarseness
• botšehali kapa ho tsikinyeha menoaneng le menoaneng.

Litaelo tsa ho sebelisa Rosart

Litaelong tsa tšebeliso, Rosart 10 mg e re moriana o nooa ka molomo ntle le ho siloa pele ho moo. Noa sethethefatsi ka metsi a lekaneng, ka ho khetheha metsi. Ho nwa lipilisi ha ho na takatso ea lijo.

Ho latela litaelo tsa Rosart tsa tšebeliso, limiligrama tse 10, moriana o lokela ho nooa ka tekanyetso e fokolang ea li-milligram tse 5 kapa li-milligram tse 10, le haeba litekanyetso tse phahameng tsa li-statin tse ling li kile tsa nkuoa pele. Khetho ea tekanyetso ea pele e latela:

• boemo ba cholesterol
• boemo ba kotsi ea ho hlaseloa ke lefu la pelo kapa stroke,
• monyetla oa ho hlaseloa ke likarolo tsa moriana.

Ka tekanyetso ea pele ea limiligrama tse 5, ngaka e ka eketsa tekanyetso ena ho li-milligram tse 10, ebe e nyolohela ho li-milligram tse 20 le li-milligram tse 40, haeba ho hlokahala.

Ho lokela ho feta libeke tse 'ne lipakeng tsa tekanyetso e ngoe le e ngoe ea lethal dose. Sekhahla se phahameng sa letsatsi ke limiligrama tse 40. Tekanyetso ena e fuoa feela bakuli ba nang le cholesterol e phahameng le ba nang le kotsi e kholo ea ho otloa ke pelo kapa stroke, moo litekanyetso tsa limiligrama tse 20 li lekaneng ho theola cholesterol ea mali.

Ha u fana ka litlhare ho fokotsa kotsi lefu la pelostroke kapa bona
mathata a amanang le bophelo bo botle, tekanyetso ea letsatsi le letsatsi e khothalletsoang ke 20 mg. Litekanyetso li ka fokotsoa haeba mokuli a e-na le matšoao a leng lethathamong la litlolo.

Dose bakeng sa bana ba lilemo li leshome ho isa ho tse leshome le metso e supileng - tekanyetso e tloaelehileng ea tloaelo ke li-milligram tse 5, lethalano le phahameng la letsatsi ke 20 mg. Moriana o lokela ho nooa hang ka letsatsi.

Motsoako oa Rosart, ho latela litaelo tsa tšebeliso, ka tekanyetso ea 40 mg ha e khothalletsoe bana.

Ho sebelisana le lithethefatsi tse ling

Rosart, ha a ntse a sebelisa lithethefatsi tse itseng, a ka tsosa ponahatso ea maikutlo a fosahetseng:

• Kamohelo ea Rosart le Cyclosporine - sethethefatsi sa ho qetela se etsa hore ho be le keketseho e ngata ponts'o ea kemiso rosuvastatin, ka hona, bakuli ba fuoeng kalafo ea Cyclosporine ba lokela ho nka Rosart ka tekanyo e tlase - e seng ho feta li-milligram tse 5 ka letsatsi.
• Hemofibrozil (Gemfibrozil) - e eketsa haholo ponahatso ea rosuvastatin. Ka lebaka la kotsi e eketsehang ea myopathy / rhabdomyolysis, phekolo e kopaneng ea Rosart le Gemfibrozil e lokela ho qojoa. Tekanyo e kholo ha ea lokela ho feta limiligrame tse 10 ka letsatsi.
• Protease inhibitors - ts'ebeliso e kopaneng ea Rosart le li-inhibitors tse ling tsa proteinase hammoho le ritonavir li na le litlamorao tse fapaneng ho rosuvastatin, mme hantle haholo phello ea ntho ea 'mele. Protease Inhibitors in mchanganyiko: lopinavir / ritonavir le atazanavir / ritonavir e ka eketsa ho pepeseha ha ricuvastatin ho fihlela makhetlo a mararo. Bakeng sa metsoako ena, tekanyetso ea Rosart ha ea lokela ho feta limiligrame tse 10 hang ka letsatsi.

Matšoao a ts'ebeliso ea lithethefatsi

Kopo ea Rosart e bontšoa maemong a latelang:

• Keketseho ea boemo ba cholesterol ea mantlha, ho kenyelletsa le lefu le ikemiselitseng liphatsa tsa lefutso, le mofuta o tsoakaneng.

• Elevated triglycerides maling.
• Ka atherosclerosis - ho liehisa tsoelo-pele ea lefu lena.
• Thibelo ea mathata a ischemic bathong ba nang le mafu a pelo le methapo e nang le kotsi e kholo ea kholo: ho tsuba, tšebeliso e mpe ea joala, lilemo tse fetang lilemo tse 50, lefutso la lefutso, khatello ea methapo ea mali, boemo bo phahameng ba protheine ea C-reactive.

Setlhare sena se sebelisoa haholo litloaelong tsa kalafo bakeng sa kalafo le ho thibela mathata a mafu a pelo. Hona joale, moriana oa Rosart le li-analogues li laeloa ho bakuli ba bangata ba nang le cholesterol e phahameng ea mali ka mokhoa o sa sebetseng oa kalafo.

Phekolo ea lijo le phepo ea methapo

Phepo e nepahetseng nakong ea kalafo ea hypercholesterolemia ha ea lokela ho ba lipalo tse phahameng haholo - ho tloha ho 2400 ho isa ho 2700 calories ka letsatsi. Ntle le moo, lijo ha lia lokela ho ba le:

• mafura, lijana tse tsubiloeng, hammoho le lijo tse phehiloeng ka grill le grill,
• Lijo tse halikiloeng tse mafura a mangata le oli,
• mahe - likotoana tse fetang tse tharo ka beke,
• botoro
• nama e nonneng le tlhapi,
• soseji, soseji, jelly, aspic,
• lebese lohle le fetang 2,5%, tranelate e bolila, tranelate,
• Bacon, Bacon

• lipisi tse mafura,
• Confectionery ka botoro ea botoro le linepe tse bolila.

Lijo tse nang le k'holeseterole e phahameng li lokela ho kenyelletsa bongata ba meroho le litholoana. Meroho e lokela ho jeoa e sa tsoa khuoa ka lisal, meroho e phehiloeng le e phehiloeng, meroho e besitsoeng. Salads, li-compotes li lokiselitsoe ho tsoa litholoana, tse halikiloeng mahe a linotsi. E le mohloli oa protheine ea ho pheha, chisi e ncha e mafura a tlase le nama e halikiloeng (khoho, veal, rabi, turkey) li sebelisoa. Ho khothaletsoa tšebeliso ea lijalo tsa koro.

Lijo tsa letsatsi le letsatsi li lokela ho aroloa lijong tse 'maloa - ho tloha ho tse' ne ho isa ho tse tšeletseng. Lijana li jeoa ka mokhoa o futhumetseng. U boetse u lokela ho noa bonyane lilithara le halofo ea metsi ka letsatsi, ntle le sopho, lero, tee.

Melao ea ho khetha ea Rosart

Maemong moo ts'ebeliso ea lijo ha e fane ka sephetho se lakatsehang mme k'holeseterole e lula e le maemong a phahameng, ho ngoliloe matlapa a Rosart kapa li-statins tse ling. Matlapa a ka nooa ka nako efe kapa efe ea letsatsi, ho sa tsotelehe nako ea ho ja. Moriana o lokela ho hlatsuoa ka metsi a hlakileng. Lijo tsa hypolipidemic tse hlalositsoeng ka holimo li lokela ho lateloa nakong ea kalafo ea statin. Litekanyetso tsa lithethefatsi maemong ka bomong li khethoa ka bonngoe. E le molao, kalafo ea Rosart e qala ka tekanyetso e fokolang ea 5 mg. Ka linako tse ling, ka lipalo tsa cholesterol e phahameng haholo, tekanyetso ea ho qala e ka ba 10 mg ea moriana. Libeke tse 'maloa kamora ho qala kalafo, ka ho hloleha kalafo, lethal dose le nyolohela ho 20 mg. Ts'ebeliso ea lithethefatsi eo k'holeseterole e tlase e lulang e le telele, ka linako tse ling nakong ea bophelo ba hau.

Bongata

Matšoao a bosholu ba rosuvastatin ha a so thehoa. Tekanyetso e le 'ngoe ea litekanyetso tse' maloa tsa letsatsi le letsatsi tsa Rosart ha e ame li-pharmacokinetics.

Phekolo: ho beoa ha phekolo ea matšoao. Taolo hodima ts'ebetso ea creatine phosphokinase (CPK) le boemo ba sebete li lokela ho netefatsoa. Haeba ho hlokahala, ho nkuoa mehato ea ho boloka tšebetso ea litho tsa bohlokoa le litsamaiso.

Ho sebetsa ha hemodialysis ha ho na monyetla.

Litaelo tse khethehileng

Monyetla oa ho ba le myopathy, ho kenyelletsa le rhabdomyolysis, o eketseha ha o ntse o nka rosuvastatin ka lithethefatsi tse latelang: cyclosporine, li-inhibitors tsa HIV tsa HIV, ho kenyelletsa motsoako oa ritonavir le atazanavir, tipranavir le / kapa lopinavir. Ka hona, ho lokela ho nahaneloa ho khethoa ha mofuta o mong oa phekolo, 'me haeba ho hlokahala, ts'ebeliso ea lichelete tsena - kalafo ka rosuvastatin e lokela ho emisoa ka nakoana.

Ha u sebelisa Rosart ka tekanyo ea 40 mg, ho hlokahala hore ho bejoe leihlo hangata ho bonts'a matšoao a ts'ebetso ea liphio.

Ha ho etsoa qeto ea ts'ebetso ea CPK, ho bohlokoa ho kenyelletsa boteng ba lintlha tse ka sitisang ho ts'epahala ha liphetho, ho kenyelletsa le ho ikoetlisa. Bakuli ba nang le keketseho e kholo mosebetsing oa pele oa CPK ba lokela ho hlahlojoa bocha kamora matsatsi a 5-7. Tabeng ea netefatso ea makhetlo a mahlano ea ho feta tloaelo ea ts'ebetso ea KFK, ts'ebeliso ea lithethefatsi e patiloe.

Tlhokomelo e khethehileng e lokela ho nkuoa ha ho laeloa Rosart ho bakuli ba nang le mabaka a kotsi bakeng sa nts'etsopele ea myopathy kapa rhabdomyolysis, ho lekola ka hloko palo ea melemo e lebelletsoeng le likotsi tse ka bang teng ho tsoa kalafong. Tlhahlobo ea bongaka e lokela ho fanoa bakeng sa sehlopha sena sa bakuli nakong eohle ea kalafo. U ke ke ua qala ho nka litafole ka ts'ebetso ea pele ea CPK makhetlo a 5 ho feta moeli o kaholimo oa tloaelo.

Ngaka e lokela ho tsebisa mokuli ka ho hlaha ha bohloko ba mesifa, mala, feberu, ho fokola hoa mesifa kapa ho choachoasela nakong ea kalafo, le ka tlhoko ea ho batla likeletso tsa bongaka hanghang. Ka keketseho e kholo ea ts'ebetso ea KFK kapa matšoao a mesifa, kalafo e lokela ho khaotsa. Ka ho nyamela ha matšoao le ho khutlisetsoa pontso ea ts'ebetso ea KFK, ho ka khonahala ho fana ka litlhare ho litekanyetso tse nyane.

Makhetlo a 1-2 ka khoeli, profid ea lipid e lokela ho hlahlojoa le hore na Rosset e fetotsoe ho latela liphetho tsa eona.

Ka nalane ea lefu la sebete le ho bakuli ba sebelisang joala hampe, ho khothalletsoa hore pele ho qala kalafo le ka mor'a likhoeli tse tharo tsa ho sebelisa lithethefatsi, ho tla khethoa matšoao a ts'ebetso ea sebete. Haeba ts'ebetso ea li-enzyme tsa hepatic ka serum ea mali e phahame makhetlo a 3 ho feta tekanyo e kaholimo e tloaelehileng, o lokela ho fokotsa tekanyetso kapa o khaotse ho nka Rosart.

Kaha motsoako oa li-inhibitors tsa HIV tsa protease in ritonavir o baka keketseho ea tsamaiso ea rosuvastatin, ho fokotseha ha lipid mahloriso ho lokela ho hlahlojoa ka hloko, keketseho e ka ba teng ea rosuvastatin ho plasma ea mali e lokela ho tsotelloa ka bobeli qalong ea kalafo le nakong ea keketseho ea tekanyetso ea moriana, 'me phetoho ea tekanyetso e loketseng e lokela ho etsoa.

Ho hlakoloa ha Rosart ho hlokahala haeba ho e-na le lipelaelo tsa lefu le tšoaetsanoang la matšoafong, le ka lebisang ho phefumoloha, ho khohlela ho sa beheng, bofokoli, ho fokotsa boima ba 'mele le feberu.

Bokhachane le pelehi

Ho latela litaelo, Rosart e tšoaetsanoa nakong ea moimana le ho anyesa.

Ho beoa ha lithethefatsi ho basali ba lilemo tsa ho tsoala ho lokela ho etsoa feela ha ba sebelisa mekhoa e tšepahalang ea ho thibela pelehi.

Mokuli o lokela ho tsebisoa ka kotsi e ka bang teng ho lesea le ka le emong nakong ea kalafo.

Haeba ho hlokahala ho nka Rosart nakong ea lebone, ho anyesa ho tlameha ho emisoa.

Ka mosebetsi o sa sebetseng oa renal

Ts'ebeliso ea Rosart e kopantsoe le e 'ngoe ea litekanyetso tsa ho hloleha ho matla ha methapo le CK e ka tlase ho 30 ml / min, ka tekanyetso ea 40 mg bakeng sa CK ho tloha 30 ho isa ho 60 ml / min.

Ka tekanyo e fokolang kapa e leka-lekaneng ea ho se sebetse hantle ha renal, ho lokisoa ha lethathamo ha ho hlokehe, tekanyetso ea pele le CC e ka tlase ho 60 ml / min e lokela ho ba 5 mg.

Ka ho se sebetse hantle ha sebete

Ho fetola tekanyetso ea rosuvastatin ha ho hlokehe bakeng sa ho hloleha ha sebete ha lintlha tse 7 kapa tlase ho sekhahla sa bana-Pugh, ka lintlha tse 8 le 9 ka sekhahla sa bana-Pugh, ho khethoa ho tlameha ho etsoa kamora tlhahlobo ea pele ea ts'ebetso ea renal.

Phihlelo le Rosart mabapi le ho hloleha ha sebete ka holimo ho lintlha tse 9 ho tekanyo ea bana-Prag ha e fumanehe.

Ho sebelisana le lithethefatsi

Ka tšebeliso e tšoanang ea Rosart:

• lithethefatsi tse thibelang liprotheine tse tsamaisang, karoloana ea eona e rosuvastatin, li eketsa monyetla oa ho nts'etsapele myopathy,
• cyclosporine e baka keketseho e kholo phello ea rosuvastatin, e eketsa palo ea eona e phahameng ea plasma ea mali ka makhetlo a 11,
• erythromycin e eketsa C_max ka 30% le ho fokotseha ha AUC ea rosuvastatin ka 20%,
• warfarin le li-anticoagulants tse ling tse sa tobang li ka baka ho feto-fetoha ha MHO (tekanyetso e tloaelehileng ea machabeng e sebelisetsoang ho supa sesupo sa tsamaiso ea mali ea mali): qalong ea ts'ebeliso le ka keketseho ea tekanyetso ea rosuvastatin, keketseho ea MHO, mme ha o hlakola kapa o fokotsa tekanyetso ea rosuvastatin, ho fokotseha ha INR MHO
• lipilisi tse theolang lipid tse fokotsang, ho kenyeletsa le gemfibrozil, li baka keketseho ea AUC le C_max Makhetlo a 2 rosuvastatin,
• li-antacid tse nang le aluminium le magnesium hydroxide li fokotsa khatello ea mali ka makhetlo a 2,
• lithibela-pelehi tsa molomo li eketsa AUC ea ethinyl estradiol ka 26% le norchedrel ka 34%,
• fluconazole, ketoconazole le li-agents tse ling tse inhibitors ea isoenzymes CYP2A6, CYP3A4 le CYP2C9 ha li bake tšebelisano-kholo ea bongaka.
• ezetimibe (ka tekanyo ea 10 mg) ho bakuli ba nang le hypercholesterolemia e eketsa AUC ea rosuvastatin (ka tekanyo ea 10 mg) ka makhetlo a 1,2, nts'etsopele ea liketsahalo tse bohloko.
• Lithibela-mafu tsa protease tsa HIV li ka lebisa ho pepesheneng ho pepesitsoeng hoa rosuvastatin,
• digoxin ha e bake tšebelisano ea bohlokoa ka tliliniki.

Nakong ea ts'ebeliso ea rosuvastatin, o lokela ho botsa ngaka haeba ho hlokahala ho e kopanya le lithethefatsi tse ling.

Litlhaku tsa Rosart ke: Akorta, Actalipid, Vasilip, Lipostat, Mertenil, Medostatin, Zokor, Simvakol, Rosuvastatin, Krestor, Rosucard, Rosistark, Rosulip, Torvazin, Tevastor, Kholetar.

Litlhahlobo tsa Rosart

Litlhahlobo mabapi le Rosarte li ntle haholo. Bakuli ba bontša phello e potlakileng ea kalafo, ba hatella hore cholesterol e theoha hantle ka ts'ebeliso ea matlapa, empa ts'ebeliso ea kamehla ea lithethefatsi e hlokahala ho boloka litekanyetso tsa eona li le maemong a tloaelehileng.

Bakuli ba bang ba lemosa hore ho arabela ka tsela e bohloko ka mokhoa oa ho hlohlona le ho potlaka, ho theola khatello ea mali, ho bonahala eka hlooho e bohloko le mpeng e ka etsahala. Empa ka kakaretso, hoa tsebahala hore Rosart e fana ka litla-morao tse fokolang ha li bapisoa le lithethefatsi tse ling tse tšoanang. Ho ba bangata, litšenyehelo tsa lithethefatsi li phahameng haholo.

Theko ea Rosart likhoebong tsa meriana

Theko ea Rosart ho latela tekanyetso:

• Rosart 5 mg ka pakete ea matlapa a 30 - ho tloha li-ruble tse 400, matlapa a 90 - ho tloha li-ruble tse 1009,
• Rosart 10 mg ka pakete ea matlapa a 30 - ho tloha li-ruble tse 569, matlapa a 90 - ho tloha li-ruble tse 1297,
• Rosart 20 mg ka pakete ea matlapa a 30 - ho tloha ho li-ruble tse 754, matlapa a 90 - ho tloha ka li-ruble tsa 1954,
• Rosart 40 mg ka pakete e le 'ngoe ea matlapa a 30 - ho tloha li-ruble tse 1038, matlapa a 90 - ho tloha li-ruble tse 2580.

Mekhoa ea kopo

Tlhaloso ea ts'ebeliso ea moriana o tsoang lenaneng la cholesterol e phahameng ka karolo e ka sehloohong ea rosuvastatin - Rosart:

• Qaleho ea kalafo ea lithethefatsi ka moriana oa Rosart e qala ka mokhoa oa ho ja k'holeseterole, e tsamaeang le phekolo eohle ka li-statins,
• Ngaka e eang teng e tla bua ka mokhoa oa ho nka Rosart, hammoho le litekanyetso li khethoa ka ho khetheha ke ngaka ho latela lipontšo tsa biochemistry tse nang le lipid spectrum (lipiliks),
• Letlapa la Rosart le tlameha ho tahoa le sa qhekelloa, 'me le hlatsuoe ka metsi a mangata. Ha ho na tlhoko ea ho tlama moriana lijong, o hloka feela ho boloka nako e nepahetseng ea ho ja letsatsi le letsatsi. Ho khothalletsoa ho nka Rosart mantsiboea pele a robala, mme sena se bakoa ke bioprocesses 'meleng oa motho, le ho tloha nakong ea karolelano ea cholesterol ke lisele tsa sebete,
• Tekanyetso ea Rosart ea pele ea li-milligram tse 5.0 kapa 10,0, hang ka letsatsi,
• Ke ngaka e eang teng feela e ka eketsang litekanyetso kapa ea sebelisa lithethefatsi ka analogue, empa eseng pejana ho feta kamora kalafo ea Rosart. Keketseho ea litekanyetso e hlaha feela ho latela liphetho tsa tlhahlobo ea biochemical le ha tekanyo e tlase e sa sebetse.
• Tekanyo e phahameng ka ho fetisisa ka letsatsi - limiligrame tse 40,0, e fuoa bakuli ba nang le kotsi e kholo ea ho theha methapo ea pelo kapa methapo ea tsamaiso ea phallo ea mali, haese feela hore moriana oa Rosart o nang le litekanyo tsa limiligrama tse 20,0 ha o hlahise ho fokotseha ha index. cholesterol (ka hypercholesterolemia ea liphatsa tsa lefutso kapa e seng ea malapa). Phekolo e nang le litekanyetso tsa Rosart ka limiligrama tse 40.0 e etsoa feela sepetlele tlasa tlhokomelo ea ngaka e lulang e le teng.
• Tekanyo e phahameng e boetse e fuoa bakuli ba nang le mofuta o matla oa systemic atherosclerosis,
• Ka kalafo e nang le litekanyetso tsa li-milligram tse ka bang 10,0, hlokomela index ea cholesterol le li-indamin tsa transaminase - kamora matsatsi a 14 a tsamaiso.
• Ka tekanyo e fokolang ea nts'etsopele ea pathologies ea setho sa renal, ha ho na tlhoko ea tokiso ea lethal dose, mme lethal dose ha le fetoloe ho motho ea tsofetseng - ea moholo ho feta lilemo tse 70, empa kalafo e lokela ho qala ka li-milligram tse 5.0 ka letsatsi,
• Bakeng sa tekanyo e phahameng ea limiligrama tse 40,0 ka letsatsi, a lule a lekola tlhaiso ea tlhahiso ea phosphokinase,
• Haeba mokuli a e-na le nalane ea myopathy, kalafo e lokela ho etsoa ka lethal dose ea Rosart ho li-milligram tse 5.0,
• Bakuli ba nang le methapo ea lisele tsa sebete ho sekhahla sa bana-Pugh, ho fihla ho lintlha tse 7,0, pele ho nako ea ho etsa tlhahlobo e felletseng mme ba sa fuoe litlolo tse phahameng ho feta li-milligram tse 5.0 ka letsatsi.

Ha litekanyetso tsa motsoako o sebetsa ka ho fetisisa letlapeng, li ba le litlamorao tse mpe ho feta tsa 'mele ho tsoa tšebetsong.

Matšoao a ho khethoa

Rosart e laetsoe kalafo ea li-pathologies tse joalo:

• Mofuta oa mantlha oa heterozygous o se nang lefutso le lelapa oa mofuta oa hypercholesterolemia (mofuta oa 2A ho ea ka Fredrickson) ho kenyelletsa lijo tsa cholesterol, hammoho le hypercholesterolemia eo eseng ea liphatsa tsa lefutso, hammoho le lijo, khatello ea maikutlo 'meleng, hammoho le kalafo ea botena,
• Le mofuta o homozygous oa hypercholesterolemia hammoho le lijo, haeba lijo feela li sa thusa ho fokotsa index ea cholesterol,
• Hyperlipidemia ea mofuta o tsoakaneng (mofuta oa 2B ho latela Fredrickson), hammoho le phepo ea cholesterol,
• Psychology ea dysbetalipoproteinemia (mofuta oa 3 ho latela Fredrickson), hammoho le lijo,
• Etiology ea lelapa ea hypertriglyceridemia (mofuta oa Fredrickson 4) e le tlatsetso e kholo lijong tsa cholesterol,
• Ho emisa tsoelo-pele ea systemic atherosulinosis hammoho le lijo, ho ikoetlisa ka ho lekaneng 'meleng, hammoho le ho theola boima ba' mele.

Thibelo ea mantlha ea meriana ea Rosart e etsoa ka li-pathologies tse joalo:

• Ka mofuta oa khale oa boiphetetso,
• Cardiac ischemia,
• Myocardial infarction le lefu la sethoathoa,
• Le lilemo tsa 'mele oa monna ke lilemo tse 50 le lilemo tse 55 ho basali,
• Phahameng e ngata ea protheine ea C
• Ka khatello ea mali
• Ka lenane la likarolo la cholesterol e fokotsitsoeng,
• Ka nikotine le bokhoba ba joala.

Ha ke na Sebelisa Rosart Neng?

Litaelo tsa ho sebelisoa ha Rosart li kenyelletsa litlhaloso tsa linyeoe tseo ho tsona lithethefatsi li ke keng tsa laeloa. Rosart ea litekanyetso tsa 5, 10, 20 mg e hlakotsoe maemong a latelang:

1. Basali ba bacha ba sa sebeliseng mekhoa e tšepahalang ho thibela bokhachane.
2. Lefu le sebetsang la sebete.
3. Methati e phahamisitsoeng ea hepatic transaminases (li-enzyme) tsa tšimoloho e sa tsejoeng.
4. Lefu la fig, le khetholloang ke ho sitisoa ke ts'ebetso.
5. Mefuta e meng ea mathata a metabolic.
6. Bana ba ka tlase ho lilemo tse 18.
7. Ts'ebetso ea Myopathic.
8. Nako ea kalafo ka cyclosporine.
9. Nako ea ho emara le ho anyesa.

Matlapa a Rosart a nang le 40 mg ea Rosuvastatin le 'ona a kopantsoe le mafu a kaholimo le maemo a mmele. Ntle le moo, Rosart 40 mg e ke ke ea sebelisoa le:

1. Phekolo ka lithethefatsi tse amanang le fiber.
2. Lefu la qoqotho (hypothyroidism).
3. Tšebeliso e mpe ea tahi.
4. Myopathies nakong e fetileng e hlahisitsoe ke tšebeliso ea li-statins le li-fibrate.
5. Maemo a ka lebisang keketseho ea plasma mahloriso a rosuvastatin.
6. Lefutso le futsitsoeng bakeng sa mafu a tsamaiso ea mesifa.
7. Ke ea morabe oa Mongoloid.

Ho ima le ho fepa ngoana

Kaha Rosart e khona ho feta ka sehokelo sa placental, tšebeliso ea lithethefatsi nakong ea boitšisinyo e hanyetsanoe.

Haeba ho ima ho hlaha nakong ea tsamaiso ea Rosart, kalafo ea "statin" e lokela ho emisoa hanghang.

Ha u fana ka litlhare tsa Rosuvastatin ho basali ba lilemo tsa ho ba le bana ba sa sebeliseng mekhoa e tšepahalang ea ho thibela pelehi mme ba le kotsi e kholo ea boimana, ho a hlokahala ho hlalosa phello e sa rateheng ea lithethefatsi tsa Rosuvastatin ka popelong. Bokhoni ba Rosuvastatin ba ho fetela lebeseng la matsoele ha boa so ka ba tiisoa, empa ha bo qheleloe ka thoko. Ka hona, Rosart ha e sebelisoe nakong ea ho anyesa.

Sebelisa Rosart ka hloko

Ntle le moo, ho na le maemo ao Rosart e sebelisoang ho ona, empa ka tlhokomeliso. Matlapa a nang le 5, 10 le 20 mg ea Rosuvastatin a beiloe ka tlhokomeliso ho:

1. Kotsi ea myopathy.
2. Baemeli ba peiso ea Mongoloid.
3. Ho feta lilemo tse 70.
4. Hypothyroidism
5. Boiphetetso ba pelehi ba ho thehwa ha methapo ea myopathic.
6. Ho ba teng ha maemo a moo letšoao la Rosuvastatin ho plasma ea mali le ka eketsehang haholo.

Ha u khetha Rosart, motho o lokela ho nahana ka hloko ka li-contraindication tse teng e le ho thibela nts'etsopele ea maikutlo a sa rateheng ho litho le litsamaisong tsa bohlokoa. Litlamorao ke tšusumetso ea li-statins tsohle le lithethefatsi tse nang le rosuvastatin le tsona lia ikhetha.

Lintho tse fapaneng tse tla etsahala

• Ts'ebetso ea methapo ea kutlo le psyche: hlooho ea hlooho, ho tšoenyeha, ho hloka boroko, mafu a sithabetsang, ho tsekela, paresthesia, nts'etsopele ea asthenic syndrome.

• Ts'oaetso ea ho ja: ho sokela, ho lula setulong hangata, bohloko ba ka mpeng, ho nyekeloa ke pelo, ho nyekeloa ke pelo, ho ruruha makhopho a manyeme, hepatitis.
• Metabolism: lefu la tsoekere.
• Sistimi ea khatello ea maikutlo: nko e phallang, pharyngitis, ho ruruha ha sinus, ho khohlela, asthma ea bronchial, ho hloleha ho phefumoloha.
• Sistimi ea musculoskeletal: myalgia (bohloko ba mesifa), molumo o eketsehileng oa mesifa, bohloko bo kopaneng le ba mokokotlo, ho phatloha hoa pelo.
• Ha motho a kula a ka hlaha ka makhopho a letlalo, marikhoe, ho ruruha ha sefahleho le molala, nts'etsopele ea anaphylaxis.
• Litlamorao tse ling tse sa batleheng.

E le molao, ponahalo ea litlamorao tse sa rateheng e amana ka kotloloho le litekanyetso tsa moriana. Khafetsa ka tokiso ea tekanyetso, matšoao a fokotseha kapa a nyamela ka botlalo.

Leha ho le joalo, ka nts'etsopele ea matšoao a myopathy le allergic reaction, o lokela ho emisa hang hang ho sebelisa Rosart mme o batle thuso ea bongaka.

Ngaka e tla u fa mekhoa le lithethefatsi tse hlokahalang bakeng sa ho tlosa litšitiso tse sa batleheng ebe o khetha sethethefatsi se seng.

Menahano ea lithethefatsi

'Marakeng oa litlama oa Russia ho na le lithethefatsi tse ngata tse nang le rosuvastatin. Li-analog tsa Rosart li hlahisoa ke lik'hamphani tsa Russia le tsa kantle ho naha. Lithethefatsi li tsebahala haholo: Rosucard, Rosulip, Rosuvastain-SZ, Roxer, Rosufast, Rustor, Rosustark, Tevastor, Mertenil. Lithethefatsi tsena kaofela ke likopi tse hlahisitsoeng hape - lijenereithara. Lithethefatsi tsa pele tse nang le Rosuvastatin ke Krestor, e entsoeng UK ke Astra Zeneca. Litsenyehelo tsa meriana e nang le rosuvastatin li fapane 'me ho latela theko ea moqapi, litekanyetso le palo ea matlapa a fumanehang ka har'a sephutheloana.

Ha u khetha moriana ho theola cholesterol ea mali, o lokela ho tataisoa, pele ho tsohle, ke likhothaletso tsa ngaka ea hau.

Ho thibetsoe ka thata ho fana ka kalafo ea statin ka boeona!

Ke ngaka feela e ka khethang ka nepo moriana o nepahetseng le litekanyetso tsa oona, o nahana ka lipontšo le li-contraindication. Ho bohlokoa hore o tsebise ngaka ea hau ka meriana eohle eo u e nkang ho qoba tšebelisano e sa batleheng ea pharmacological.

Litafole tsa k'holeseterole ea Rosart: litlhahlobo le matšoao a sebelisoang

• E tsitsisa maemo a tsoekere nako e telele
• E khutlisa tlhahiso ea insulin ea "pancreatic"

E 'ngoe ea lintho tsa bohlokoa le tse bohlokoa bakeng sa' mele oa motho ke cholesterol. Ho bohlokoa haholo hore matšoao a eona a lumellane le tloaelo, hobane ha e na khaello kapa ha e na le ts'usumetso e mpe bophelong. Keketseho ea LDL maling e etsa hore ponahalo ea atherosclerosis, e khetholloang ka liphetoho lipolitiking tsa methapo ea mali le ho fokotseha ha matla a tsona.

Hajoale, motheo oa thibelo ea maloetse a fapa-fapaneng a pelo le lithethefatsi tse amehang taolong ea metabolism ea cholesterol 'meleng oa motho. Li teng ka mefuta e mengata e fapaneng hantle. E 'ngoe ea lithethefatsi tse phahameng ka ho fetisisa, tse sebetsang le tse sireletsehileng tsa lipid ke Rosart.

Mabapi le katleho, Rosart e nka boemo bo etellang pele har'a sehlopha sa li-statins, e fokotsa ka katleho matšoao a "mpe" (lipalo tse tlase tsa li-lipoprotein) le ho eketsa boemo ba "cholesterol" e ntle.

Bakeng sa li-statins, haholo-holo Rosart, mefuta e latelang ea ts'ebetso ea kalafo ke tšobotsi:

• E thibela ts'ebetso ea li-enzyme tse nkang karolo ea motsoako oa cholesterol ho hepatocytes. Ka lebaka la sena, ho fokotseha ho hoholo hoa cholesterol ea plasma hoa bonahala,
• E thusa ho fokotsa LDL ho bakuli ba nang le lefutso la lefutso. Ena ke thepa ea bohlokoa ea li-statins, hobane lefu lena ha le phekoloe ka tšebeliso ea meriana ea lihlopha tse ling tsa meriana.
• E na le phello e molemo mosebetsing oa methapo ea pelo le methapo, e fokotsa haholo menyetla ea mathata a teng liphatseng tsa eona tse sebetsang le tse amanang le eona.
• Ts'ebeliso ea motsoako ona oa lithethefatsi e lebisa ho fokotseha hoa cholesterol e felletseng ka 30%, mme LDL - ho fihla ho 50%,
• E eketsa HDL ea plasma
• Ha e tsose ponahalo ea neoplasms hape ha e na phello ea mutagenic liseleng tsa 'mele.

Theko ea Rosart

Phapang ea litšenyehelo tsa moriana oa k'holeseterole ea Rosart e itšetlehile ka se hlahisoang ke ntho e sebetsang ho bona (mg) le palo ea litafole ka bobona.

Theko ea li-milligram tsa Rosart 10 tsa likotoana tse 30 ka har'a sephuthelo e tla ba li-ruble tse 509, empa theko ea Rosart e nang le litaba tse tšoanang tsa thepa, empa likotoana tse 90 ka har'a sephutheloana li phahame habeli - li-ruble tse ka bang 1190.

Likotoana tsa Rosart 20 mg 90 ka pakete e batla li-ruble tse 1,500.

O ka reka moriana ho litlama tsa litlama ka litlhare. Ho lokela ho hopoloa hore pele u qala kalafo, o lokela ho etela ngaka, ho hlahlojoa ka botlalo le ho phela bophelo bo phetseng hantle ho fihlela sephetho se phahameng.

Mokhoa oa ho nka li-statins litsebi li tla bolela videong ena.

• E tsitsisa maemo a tsoekere nako e telele
• E khutlisa tlhahiso ea insulin ea "pancreatic"

Ho sebelisana le meriana e meng

• Meriana ea antacid e fokotsa khatello ea mali ea Rosart maling a 35.0%,
• Ha e nkuoa le Digoxin, ho na le kotsi ea ho nts'etsapele li-pathologies, myopathy le rhabdomyolysis,
• Li-antibiotic tsa sehlopha sa erythromycin le clearithromycin, li eketsa khatello ea mali ea Rosart ka har'a mali a plasma,
• Ka kalafo ea cyclosporin. Khokahano ea rosuvastatin e nyoloha ka makhetlo a fetang a 7,
• Ha u sebelisa Rosart le inhibitors, khatello ea maikutlo ea rosuvastatin ea eketseha, e nang le tšusumetso ea nts'etsopele ea myopathy,
• Ha u phekola warfavir, ho hlokahala hore ho hlahlojoe nako ea prothrombin,
• Niacin ea lithethefatsi e baka kotsi ea rhabdomyolysis.

Litlhahiso tsa ho khethoa

Moriana oa Rosart o laeloa ke lingaka tse eang ho latela litholoana tsa tlhahlobo ea methapo le ea laboratori.

Pele o qala kalafo, bakuli bohle ba lokela ho tsebisoa ke ngaka ka litlamorao tse mpe tse ka hlahisoang ke ho nka moriana oa Rosart.

Ho totobatsoa ka ho khetheha menyetla ea ho opeloa ke mesifa le nts'etsopele ea myopathy ea methapo:

• Nakong ea kalafo ea Rosart ho litekanyetso tsa limiligrama tse 20,0 le 40.0 tsa motsoako o sebetsang, ts'ebetso ea indexine ea phosphokinase maling a plasma e lula e beiloe leihlo, hammoho le mosebetsi oa methapo ea mesifa le lisele tsa liphio. Keketseho ea ts'ebetso ea moeine phosphokinase ke sesupo sa nts'etsopele ea pathology myopathy ka mesifa ea mesifa. Pheko e lokela ho emisoa, kapa litekanyetso li lekantsoe hanyane,
• Ka matla afe kapa afe a bohloko ba mesifa kapa masapo, molwetse o hloka ho bona ngaka. Khafetsa ho tloha ho nka moriana oa Rosart, bofokoli ba mesifa bo hlaha, 'me li-autoantibodies li thehoa ho tsona,
• Haeba mosali a fumanoe a imme ka nako ea kalafo ea Rosart le sethethefatsi seo, moriana o lokela ho hlakoloa ka potlako, mme mosali oa moimana o lokela ho hlahlojoa, mme lesea le lokela ho hlahlojoa.
• Haeba tšebeliso e ngata ea moriana oa Rosart e etsahala, joale o lokela ho etela ngaka ka potlako. Ngaka e tla fana ka kalafo ea matšoao, hemodialysis haeba lefu la Rosart le sa sebetse.

Litšoantšo tsa malapeng

Litlhaku tse tsoang kantle ho naha

Qeto

Ts'ebeliso ea moriana oa Rosart ho theola index ea cholesterol e lumelloa feela ka ho beoa ka tekanyo e nepahetseng ke ngaka e eang. Ha hoa lumelloa ho fetola tekanyetso ka boeena.

Haeba u latela litlhahiso tsohle tsa ngaka mme u latela lijo, joale u ka potlakisa ts'ebetso ea kalafo.

Phekolo e etsoa ka ho lekola khafetsa index ea cholesterol.

Vitaliy, ea lilemo tse 60: E se e le selemo ke nka Rosart. Cholesterol ehlile e tla theohela boemong bo tloaelehileng kamora ho qeta pilisi bakeng sa khoeli.

Ngaka e ile ea nkhothaletsa hore ke noe moriana ona ka tsela ea ho arola, hobane ke hloka ho boloka k'holeseterole ea ka e tloaelehileng.

Pele ke nka moriana ona, ke ne ke ja lijo tse matlafatsang, empa ho ne ho se na phokotseho ea index ea cholesterol.

Ke feela ka ho khethoa ha Rosart le lijo, ke khonne ho theola 'me joale ke boloka cholesterol ea ka e le tloaelehileng. Litla-morao li ne li le qalong ea thupelo ka mokhoa oa leqhetsoana la letlalo le mala, empa kamora libeke tse peli tsa taolo ba feta.

Valentine ea lilemo tse 51: Ngaka e ile ea mpehela Rosart ho tlatselletsa le lijo, ka lebaka la 'mele oa ka o moholo le cholesterol e phahameng (9.0 mmol / L).

Bakeng sa likhoeli tse 3 tsa ho nka moriana le lijo, ke atlehile ho theola li-kilos tse 12, mme cholesterol e theohetse ho 6,0 mmol / L.

Ke khotsofetse ke sephetho, empa ho a hlokahala ho tsoela pele kalafo ka matlapa a Rosart, ho fihlela ho thehoa hoa k'holeseterole e tsoetseng pele ka tloaelo. Ha kea ka ka utloa litla-morao leha e le life tse tsoang ho lithethefatsi nakong ea kalafo.