GLYCLAZIDE MV

Glyclazide MB ke boitokisetso ba molomo ba hypoglycemic bo amanang le litlamorao tsa sulfonylurea molokong oa 2. Moriana:

1. e susumetsa tlhahiso ea "insulin" ea hormone,
2. e ntlafatsa sephetho sa "insulin-secretory" ea "tsoekere"
3. e theola tsoekere e maling
4. e phahamisa kutloisiso ea insulin liseleng tsa pherekano.,
5. normalizing boemo ba ho itima lijo glycemia,
6. e fokotsa tlhahiso ea glucose,
7. ntle le ho ama metabolism ea carbohydrate, moriana o ntlafatsa microcirculation.

Glyclazide e fokotsa kotsi ea ho bolaoa ha mali ka har'a methapo e menyenyane, e ama ka nako e ts'oanang mekhoa e 'meli e amehang ho hlahiseng mathata a lefu la tsoekere:

• inhibition e sa lekanyetsoang ea khokahanyo ea liplatelete le ho ikopanya,
• bakeng sa ho fola
• ho fokotsa lintlha tsa ts'ebetso ea platelet (thromboxane B_2, beta thromboglobulin).

Contraindication

• mofuta oa 1 lefu la tsoekere
• sensitivity e phahameng ho Glyclazide kapa likarolo tsa lithethefatsi (ho sulfonamides, ho sulfonylurea derivatives),
• ho ima le ho nyekeloa
• sebete haholo kapa ho hloleha ha meno,
• ho nka miconazole,
• lefu la tsoekere
• lefu la tsoekere
• lefu la tsoekere ketoacidosis,
• lilemo tse 18
• khaello ea lactase
• congenital lactose tshoarello,
• glucose-galactose malabsorption .. Lingaka ha li khothaletse tšebeliso ea lithethefatsi ka nako e tšoanang hammoho le danazol kapa phenylbutazone.

Nako e lokelang ho nkuoa ka hloko

Gliclazide e ke ke ea sebelisoa ntle le lengolo la ngaka, hobane lithethefatsi ha li lokele motho e mong le e mong. Mona ke lenane la maemo ao ho ona a lokelang ho sebelisoa ka hloko:

1. phepo e sa leka-lekanang kapa e sa sebetseng,
2. botsofali
3. hypothyroidism
4. pituitary kapa adrenal ho haella,
5. mafu a matla a tsamaiso ea methapo ea pelo (atherosclerosis, lefu la pelo),
6. hypopituitarism,
7. phekolo ea glucocorticosteroid ea nako e telele,
8. ho se sebetse hantle ha sebete kapa liphio,
9. glucose-6-phosphate dehydrogenase ea haelloa,
10. bokhoba ba joala.

Ela hloko! Setlhare se laeloa feela batho ba baholo!

U ka nka joang nakong ea kemaro le kanyeso

Ha ho na datha mabapi le ts'ebeliso ea moriana nakong ea kemaro. Tlhahisoleseling mabapi le ts'ebeliso ea tse ling tse tsoang sulfonylurea nakong ea kemolo e lekanyelitsoe.

Lithutong tsa laboratori mabapi le liphoofolo, litlamorao tsa lithethefatsi ha lia ka tsa fumanoa. Ho fokotsa kotsi ea tšoaetso ea tlhaho, o hloka taolo e hlakileng ea lefu la tsoekere (kalafo e nepahetseng).

Bohlokoa! Litlhare tsa Hypoglycemic tsa molomo nakong ea kemolo ha li laeloe. Bakeng sa kalafo ea lefu la tsoekere nakong ea kemolo, insulin ea lithethefatsi e khethoa. Ho amoheloa meriana ea hypoglycemic ho khothalletsoa hore e nkeloe sebaka ke kalafo ea insulin.

Ntle le moo, molao ona o sebetsa maemong a ha moimana a bile teng ka nako ea ho sebelisa moriana, mme haeba boimana bo kenyelletsoa feela mererong ea mosali.

Ka lebaka la taba ea hore ha ho na datha ea ho kenella ha moriana lebese la matsoele, kotsi ea ho hlaha ea "fetal hypoglycemia" ha e khetholloe. Ka hona, ts'ebeliso ea Gliclazide nakong ea matsoele e hlakotsoe.

Litaelo le litekanyetso

Matlapa a lokolotsoeng a 30 mg a lokela ho nooa nako e le ngoe ka lijo tsa hoseng. Haeba mokuli a fumana kalafo ena ka lekhetlo la pele, tekanyetso ea pele e lokela ho ba 30 mg, sena se sebetsa le ho batho ba lilemo tse fetang 65. Butle-butle fetola tekanyetso ho fihlela phello e hlokahalang ea kalafo e etsahala.

Khetho ea tekanyetso e khothalletsoa ho latela boemo ba tsoekere maling le kamora ho qala kalafo. Phetoho efe kapa efe ea kamora e latelang e ka etsoa feela kamora libeke tse peli.

Glyclazide MB e ka nkeloa sebaka ke matlapa a Glyclazide ka tokollo e tloaelehileng (80 mg) ka tekanyetso ea letsatsi le letsatsi ea likotoana tsa 1-4. Haeba ka lebaka le itseng mokuli a hloloehile moriana, lethal dose le latelang ha lea lokela ho ba holimo.

Haeba matlapa a Glyclazide MB 30 mg a sebelisoa ho nkela sethethefatsi se seng sa hypoglycemic, nako ea phetoho ha e hlokehe ho sena. Hoa hlokahala feela ho phethela ho lekana letsatsi le leng le le leng la lithethefatsi tse fetileng mme feela ka letsatsi le hlahlamang ho nka Gliclazide MB.

Bohlokoa! Haeba mokuli a kile a phekoloa ka sulfonylureas ka nako e telele ea halofo ea bophelo, ho shebella ka hloko tsoekere ea mali maling ho hlokahala bakeng sa libeke tse peli.

Sena sea hlokahala e le ho qoba nts'etsopele ea hypoglycemia, e ka hlahang khahlano le semelo sa lits'oaetso tse setseng tsa kalafo e fetileng.

Moriana o ka kopantsoe le alpha-glucosidase inhibitors, biguanides kapa insulin. Bakuli ba nang le bothata ba ho hlaphoheloa ha reisal ka bonolo kapa ka tekanyo e itseng, Gliclazide MB e khethoa ka tekanyetso e lekanang le ea bakuli ba sebetsang hantle ba renal. Setlhare se kopantsoe le ho hloleha ho matla ha a liphio.

Bakuli ba kotsing ea ho ba le hypoglycemia

Bakuli ba kotsing ea ho ba le hypoglycemia:

1. ha e leka-lekane kapa ea haelloa ke phepo,
2. ka mathata a fokolang kapa a fokolang a endocrine (hypothyroidism, adrenal le pituitary insuffence),
3. ka ho felisoa ha li-agents tsa hypoglycemic kamora ts'ebeliso ea nako e telele,
4. ka mefuta e kotsi ea methapo ea pelo (lefu la atherosmithosis le tloaelehileng, carotid arteriosulinosis, lefu la pelo le coronary),

Bakeng sa bakuli ba joalo, Glyclazide MB ea lithethefatsi e fanoe ka tekanyetso e fokolang (30 mg).

Litlamorao

Lithethefatsi li ka baka glycemia, e bonahatsoang ke matšoao a latelang:

• tlala
• mokhathala, bofokoli bo matla,
• hlooho e opang, leseli,
• mofufutso o eketsehileng, ho thothomela, paresis,
• arrhythmia, palpitations, bradycardia,
• khatello e phahameng ea mali
• ho hloka boroko, ho otsela,
• ho se be bonolo, ho tšoenyeha, ho ba mabifi, khatello ea maikutlo,
• ho ferekana
• khatello ea maikutlo,
• karabelo e liehang le ho se khone ho tsepamisa mohopolo,
• mathata a kelello
• ho sitisoa hoa pono
• aphasia
• tahlehelo ea boitšoaro
• boikutlo ba ho hloka thuso
• Ho phefumoloha ho sa tebang
• cramps
• delirium
• ho lahleheloa ke kelello, komisi.

1. erythema
2. lekhopho la letlalo
3. urticaria
4. ho hlohlona ha letlalo.

Ho na le litla-morao tse tsoang ho tšilo ea lijo:

• bohloko ba ka mpeng
• ho sokela
• ho nyekeloa, ho hlatsa,
• hangata "cholestatic jaundice hepatitis", empa ba hloka ho tlosoa ha moriana hanghang.

Ho sebelisa tekanyetso e phahameng le tšebelisano

Ha u na le litekanyetso tse sa lekaneng, monyetla oa ho ba le boemo bo matla ba hypoglycemic, o ka tsamaeang le mathata a methapo ea kutlo, ho akheha, ho ferekana. Ponong ea pele ea lipontšo tsena, mokuli o hloka ho kena sepetlele ka potlako.

Haeba ho kula ho belaelloa ka ho ferekanya kelello ka hypoglycemic coma kapa ho fumanoa, tharollo ea 40-50% dextrose e fanoa kahare ho mokuli. Kamora moo, ba beha lerotholi le nang le tharollo ea 5% ea dextrose, e hlokahalang ho boloka phallo e tloaelehileng ea tsoekere maling.

Kamora hore mokuli a hlaphoheloe kelellong hape, e le hore a qobe ho pheta-pheta hypoglycemia, o lokela ho fuoa lijo tse nang le lik'habohaedreite tse bonolo tse jang lijo. Sena se lateloa ke ho lekola ka hloko maemo a tsoekere ea mali le ho hlahloba mokuli lihora tse 48 tse latelang.

Ketso tse ling, ho latela boemo ba mokuli, li khethoa ke ngaka e eang. Ka lebaka la litlama tse boletsoeng tse tlamang liprotheine tsa plasma, dialysis ha e na thuso.

Glyclazide e ntlafatsa ts'ebetso ea li-anticoagulants (warfarin), boemo feela ke hore u ka hloka ho ntlafatsa tekanyetso ea anticoagulant.

Danazole hammoho le Gliclazide ke phello ea lefu la tsoekere. Ka bobeli nakong ea ts'ebeliso ea danazol le kamora ho itokolla, taolo ea tsoekere le phetoho ea litekanyetso tsa Glyclazide lia hlokahala.

Tsamaiso ea systemic ea phenylbutazone e ntlafatsa phello ea hypoglycemic ea Gliclazide (e liehisa ho chesoa hoa 'mele, e tlosa thepa lipuisanong tsa liprotheine tsa mali. Ho hlahlojoa letheba la Glyclazide le ho lekola tsoekere ea mali hoa hlokahala. Ka bobeli ka nako ea ho nka phenylbutazone, le kamora ho e tlosa.

Ka tsamaiso ea ts'ebetso ea Miconazole le ha o sebelisa gel kahara molomo, e ntlafatsa phello ea hypoglycemic ea lithethefatsi, ho fihlela nts'etsopele ea komello.

Ethanol le lintho tse tsoang ho eona li ntlafatsa hypoglycemia, li ka lebisa ho nts'etsopele ea hypoglycemic coma.

Ha e sebelisoa hammoho le lithethefatsi tse ling tsa hypoglycemic (biguanides, acarbose, insulin), fluconazole, beta-blockers, H2-histamine receptor blockers (cimetidine), angiotensin-converting enzyme inhibitors (enalapril, Captoprilamide antioxidants, non-steroidal sulfide inhibitors hypoglycemic athari, ka ho latellana, kotsi ea hypoglycemia.

Chlorpromazine ka litekanyetso tse kholo (tse fetang 100 mg / ka letsatsi) e eketsa tsoekere e maling, e thibelang sephiri sa insulin. Ka bobeli nakong ea ts'ebeliso ea chlorpromazine le kamora ho itokolla, taolo ea tsoekere le phetoho ea tekanyetso ea Gliclazide lia hlokahala.

GCS (rectal, ntle, intraarticular, systemic) e eketsa tsoekere ea mali ka nts'etsopele ea ketoacidosis. Ka bobeli nakong ea ts'ebeliso ea GCS le kamora ho tlohela, taolo ea tsoekere le phetoho ea tekanyetso ea Gliclazide lia hlokahala.

Terbutaline salbutamol, erythrocyte e kenang - e eketsa tsoekere ea mali. Ho laoloa ha tsoekere maling ho hlokahala 'me ha ho hlokahala, phetoho ea kalafo ea "insulin".

Litlhahiso tse khethehileng le foromo ea tokollo

Motsoako oa Gliclazide MB o sebetsa hantle feela ha o kopana le lijo tse nang le khalori e fokolang, e nang le lik'habohaedreite tse nyane. Ho lekola khafetsa khatello ea tsoekere, ka mpeng e se nang letho le ka mor'a lijo, hoa hlokahala. Sena se bohlokoa haholo sethaleng sa kalafo.

Nakong ea kalafo le sethethefatsi, e le ho qoba likotsi le likotsi tseleng, ho khothalletsoa ho qoba ho khanna likoloi le ho sebetsa ka mekhoa e kotsi e hlokang tlhokomelo e phahameng le lebelo la karabelo.

Matlapa a 30 mg, a pakiloe ka marang-rang a likotoana tse 10.

Bophelo ba sehatsetsing ba Gliclazide ke lilemo tse 3, kamora moo bo ke keng ba sebelisoa. Setlhare se lokela ho bolokoa sebakeng se omileng, se lefifi le se phodileng, se sa fumaneheng ho bana.

Libakeng tse fapaneng tsa naha, theko ea lithethefatsi e fapana ho tloha ho li-ruble tse 120 ho isa ho tse 150. Re bua ka lipakete tse nang le matlapa a 60. Ho na le ho paka ka har'a makotikoti a polymer. Pitsa e le 'ngoe kapa marang-rang a le 1 ho isa ho a tšeletseng e kentsoe lebokose la karete.

Phapang ea theko e latela lintlha tse fapaneng: moetsi, sebaka, boemo ba litlama.

Mokhoa oa kopo

Bakeng sa tsamaiso ea molomo. Lithethefatsi Gliclazide MV e etselitsoe phekolo ea batho ba baholo feela.
Tekanyetso ea letsatsi le letsatsi ea MV Glyclazide e ka fapana ho 30 mg ho isa ho 120 mg. Ho khothalletsoa ho nka nako e le 'ngoe ka nako ea lijo nakong ea lijo tsa hoseng, u otlanye matlapa ka botlalo ntle le ho hlafuna.
Haeba u qeta ho sebelisa moriana o, u ke ke ua eketsa lethal dose ka le latelang.!
Joalo ka lithethefatsi tse ling tsa hypoglycemic, lethal dose la lithethefatsi ka le leng le le leng le lokela ho khethoa ka bonngoe, ho latela karabelo ea metabolic ea mokuli.
Motsoako oa pele o khothalelitsoeng ke 30 mg (1 letlapa la Gliclazda MV le lethal la litekanyetso tsa 30 mg kapa 1 2 le litekanyetso tsa 60 mg).
Tabeng ea taolo e sebetsang ea likhahla tsa tsoekere ea mali, lethal dose lena le ka sebelisoa e le pheko ea tlhokomelo.
Haeba ho se na taolo e lekaneng ea maemo a tsoekere, tekanyetso e ka eketseha hanyane ka hanyane ho isa ho 60 mg, 90 mg kapa 120 mg ka letsatsi. Nako e pakeng tsa keketseho e latellanang ea tekanyetso ea moriana e lokela ho ba bonyane khoeli e le 'ngoe, ntle le haeba boemo ba tsoekere ea mali bo sa fokotsehe kamora libeke tse peli tsa kalafo. Maemong a joalo, tekanyetso e ka eketsoa libeke tse peli kamora ho qala kalafo.
Sekhahla se phahameng se khothalletsoang letsatsi le letsatsi ke 120 mg.
Letlapa le le leng la 60 mg Glyclazide MV e fetotsoeng e lokisitsoeng le lekana le matlapa a mabeli a 30 mg a Gliclazide MV a lokisitsoeng. Letlapa le lokolloang la Glyclazide MV 60 mg le bonolo ho le arola, e leng se lumellang litekanyetso tsa lithethefatsi hore li fetoloe.
Sebelisa hammoho le lithethefatsi tse ling tsa antidiabetes
Gliclazide MB e ka sebelisoa hammoho le biguanidines, alpha-glucosidase inhibitors kapa insulin. Bakeng sa bakuli bao boemo ba tsoekere ea mali ba bona bo sa laoloeng ka ho lekana ka ho nka Glyclazide MV, kalafo ea insulin e ka fanoa tlasa tlhokomelo e haufi ea bongaka.
Batho ba baholo
Litekanyetso tse khothalelitsoeng bakeng sa batho ba tsofetseng li tšoana hantle le tsa batho ba baholo ba ka tlase ho lilemo tse 65.
Ho hloleha hape
Melemo ea moriana e khothalelitsoeng bakeng sa ho se sebetse hantle ha rempole e bobebe ho isa tekanyong e lekanang le ea batho ba nang le ts'ebetso e tloaelehileng ea a renal.
Bakuli ba nang le kotsi e eketsehang ea hypoglycemia: khaello ea phepo e nepahetseng, mafu a nang le endocrine e mpe kapa e sa fuoeng hantle,
Kamora ho hlakoloa ha kalafo ea kalafo e telele e telele le / kapa e phahameng ea corticosteroid, maemong a matla a methapo (lefu le matla la pelo, ho ruruha ho hoholo ha methapo ea methapo, ho nyehlisa mafu a methapo).
Ho khothalletsoa ho fana ka litlhare ka lethal dose le bonyane la 30 mg la letsatsi le letsatsi.

Litla-morao:
Phekolo Glyclazide MV ho ka lebisa ho hypoglycemia maemong a ho ja lijo tse sa sebetseng mme haholo maemong a ho tlōla lijo.
Matšoao a ka bang teng a hypoglycemia: hlooho e opang, tlala e matla, ho nyekeloa, ho hlatsa, mokhathala, ho sitisoa ha boroko, ho ferekana, ho tsepamisa mohopolo, ho fokotseha bokhoni ba ho lekola maemo le ho liehisa karabelo, khatello ea maikutlo, ho ferekana kelellong, mathata a pono le puo, aphasia, ho thothomela , paresis, ho fokotseha ha maikutlo, ho tsekela, ho ikutloa u se na thuso, tahlehelo ea boitšoaro, maemo a marang-rang, marang-rang, ho hema ka mokhoa o sa tsitsang, bradycardia, ho otsela le ho felloa ke letsoalo, tse ka lebisang ho hlatsoa kapa u bolaee.

Ntle le moo, ho ka ba le lipontšo tsa ho hanyetsa ha adrenergic tse kang ho fufuleloa, letlalo la mala, ho tšoenyeha, tachycardia, khatello e phahameng ea mali, lebelo la pelo, angina pectoris le pelo.
Ka tloaelo matšoao ana a nyamela kamora ho nka nama ea kolobe (tsoekere). Ka nako e ts'oanang, linoko tse monate tsa maiketsetso ha li na phello ena.
Litlhaselong tse matla le tse tsoelang pele tsa hypoglycemia, le haeba e ka felisoa ka nakoana ka tsoekere, ho potlakile ho fana ka tlhokomelo ea bongaka kapa, haeba ho hlokahala, esita le ho kulisa mokuli sepetlele.
Litlamorao tse ling tse sa batleheng:
mathata a tsamaiso ea ka mpeng (ho nyekeloa ke pelo, lets'ollo, ho utloa bohloko bo boholo ka mpeng, ho qhekelloa, bohloko ba ka mpeng, ho hlatsa, ho nyekeloa le pelo. Matšoao ana ha a na letho ha a khethoa ke Gliclazide MV nakong ea lijo tsa hoseng.
Litla-morao tse sa tlalehiloeng hofeta:
karohano: ho hlohlona, ​​urticaria, lekhopho la maculopapular,
ho tsoa ho hematopoietic le lymphatic system: liphetoho tsa hematological. Sena e kanna ea ba le anemia, leukopenia, thrombocytopenia, granulocytopenia. Hangata, matšoao ana a nyamela kamora hore o khaotse ho sebelisa moriana,
ho senyeha ha lesapo la mokokotlo le lesapo la nyooko: ho eketsa tšebetso ea li-enzymes tsa "sebete" (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase), hepatitis (linyeoe tse ikhethileng).Haeba choleundatic jaundice e etsahala, kalafo e lokela ho khaotsa. Hangata, matšoao ana a nyamela kamora hore o khaotse ho sebelisa moriana,
mathata a ophthalmological: bofokoli ba pono ba nakoana.

Ho sebelisana le lithethefatsi tse ling

Ka linako tse ling ho hlokahala hore u fetole tekanyetso ea moemeli oa antidiabetesic nakong ea kalafo ea danazol le ka mor'a eona.
Ho kanna ha hlokahala hore o fetole tekanyetso ea lithethefatsi tsa antidiabetic ka nako eo le ka mor'a ho phethoa ha taolo ea danazol.
Metsoako e hlokang tlhokomelo e khethehileng.
Chlorpromazine: tekanyetso e phahameng (tse fetang 100 mg ka letsatsi) e eketsa tsoekere ea mali, e fokotsa secretion ea insulin.
Glucocorticosteroids (ts'ebeliso ea tšebetso le ea li-topical: tsamaiso ea methapo, letlalo le tsamaiso ea methapo) le tetracosactrin e eketsa tekanyo ea tsoekere ea mali ka nts'etsopele ea ketoacidosis (ho fokotseha ha ts'ebetso ea carbohydrate ka glucocorticosteroids).
Progestogens: Kameho ea lefu la tsoekere ea litekanyetso tse phahameng tsa progestogens. β-2-adrenostimulants - ritodrin, salbutamol, terbutaline: (ts'ebeliso ea methapo): litekanyetso tsa glucose tse eketsehileng.
Ela hloko ka ho khetheha bohlokoa ba ho itlhahloba tsoekere ea mali. Haeba ho hlokahala, fetisetsa mokuli kalafo ea insulin.
Haeba o hloka ho sebelisa metsoako e kaholimo, o lokela ho ela hloko ka ho khetheha ho laola maemo a tsoekere ea mali. Ho kanna ha hlokahala hore o kenye litekanyetso tsa MV Glyclazide ka bobeli nakong ea phekolo e kopaneng le ka mor'a ho khaotsa lithethefatsi tse ling.
Mekhahlelo ea ho nahana.
Kamohelo ea litokisetso tsa anticoagulant (warfarin): ho amoheloa ha lintho tse tsoang sulfonylurea ho ka phahamisa phello ea anticoagulant ea litokisetso tse joalo. Ho ka 'na ha hlokahala hore u ntlafatse tokiso ea litheko tsa anticoagulant.

Tšusumetso ho bokhoni ba ho khanna makoloi le mekhoa ea ho laola:
Bakuli ba Gliclazide MV, lokela ho hlokomela matšoao a hypoglycemia mme o sebelise tlhokomeliso ha o khanna kapa o etsa mosebetsi o hlokang lebelo le leholo la maikutlo le kelello.

Maemo a polokelo

Sebakeng se sirelelitsoeng mochesong le lebone ka mocheso o sa feteng 25 ° C.
Qoba hole le bana.

Letsatsi la ho felloa ke nako:
Bakeng sa litekanyetso tsa 30 mg, bophelo ba sethala ke selemo se le seng.
Bakeng sa litekanyetso tsa 60 mg, bophelo ba lishelefo ke lilemo tse peli.
Se ke oa sebelisa kamora letsatsi la ho felloa ke nako le bontšitsoeng ka har'a sephutheloana.

Fomu ea tokollo

Lithethefatsi Gliclazide MV e fanoe ka foromo tmodumo o hlophisitsoeng oa tokollo:
Matlapa a potileng a 'mala o mosoeu kapa o batlang o le tšoeu o nang le sebopeho sa cylindrical se nang le bevel (litekanyetso tsa 30 mg).
Matlapa a pota-potileng a 'mala o mosoeu kapa o batlang o le mosoeu ka sebopeho sa cylindrical ka chamfer le kotsi (litekanyetso tsa 60 mg).
Matlapa a 10 ka har'a mekotla ea blister. Lipakete tse tharo kapa tse tšeletseng tsa lithutsoana, hammoho le litaelo tsa tšebeliso ea pakete ea karete.