Metformin-Teva analogue
Leqephe lena le fana ka lethathamo la li-analogues tsa Metformin-Teva ka sebopeho le matšoao bakeng sa tšebeliso. Lethathamo la li-analogues tse theko e tlaase, hape u ka bapisa litheko libakeng tsa meriana.
- Analogue ea theko e tlaase ka ho fetisisa ea Metformin-Teva:Glucophage
- Analogue e tummeng ka ho fetisisa ea Metformin-Teva:Metformin
- Sehlopha sa ATX: Metformin
- Motsoako o sebetsang: metformin
| # | Sehlooho | Theko ho la Russia | Theko Ukraine |
|---|---|---|---|
| 1 | Glucophage metformin Analogue ka sebopeho le pontsho | 12 rub | 15 UAH |
| 2 | Metformin metformin Analogue ka sebopeho le pontsho | 13 rub | 12 UAH |
| 3 | Reduxin Met metformin, sibutramine Analogue ka sebopeho le pontsho | 20 rub | -- |
| 4 | Metformin Canon metformin, ovidone K 90, starch ea poone, crospovidone, magnesium stearate, talc Analogue ka sebopeho le pontsho | 26 rub | -- |
| 5 | Sebelisa Analogue sebopeho le pontšo | 37 rub | -- |
Ha u bala litšenyehelo Metformin-Teva ea theko e tlaase theko e fokolang e fumanoeng lenaneng la theko e fanoeng ke li-pharmacies e ile ea tsotelloa
| # | Sehlooho | Theko ho la Russia | Theko Ukraine |
|---|---|---|---|
| 1 | Metformin metformin Analogue ka sebopeho le pontsho | 13 rub | 12 UAH |
| 2 | Reduxin Met metformin, sibutramine Analogue ka sebopeho le pontsho | 20 rub | -- |
| 3 | Sebopeho sa Siofor le analogue | 208 rub | 27 UAH |
| 4 | Glucophage metformin Analogue ka sebopeho le pontsho | 12 rub | 15 UAH |
| 5 | Sebelisa Analogue sebopeho le pontšo | 37 rub | -- |
E fuoe lenane la lingaka tsa lithethefatsi e ipapisitse le lipalo-palo tsa litlhare tse kopiloeng ka ho fetisisa
Li-analog mabapi le sebopeho le pontšo ea ts'ebeliso
| Sehlooho | Theko ho la Russia | Theko Ukraine |
|---|---|---|
| Bagomet Metformin | -- | 30 UAH |
| Glucofage metformin | 12 rub | 15 UAH |
| Glucophage xr metformin | -- | 50 UAH |
| Reduxin Met Metformin, Sibutramine | 20 rub | -- |
| Dianormet | -- | 19 UAH |
| Diaformin metformin | -- | 5 UAH |
| Metformin metformin | 13 rub | 12 UAH |
| Metformin sandoz metformin | -- | 13 UAH |
| Siofor | 208 rub | 27 UAH |
| Foromo metformin hydrochloride | -- | -- |
| Emnorm EP Metformin | -- | -- |
| Megifort Metformin | -- | 15 UAH |
| Metamine Metformin | -- | 20 UAH |
| Metamine SR Metformin | -- | 20 UAH |
| Metfogamma metformin | 256 rub | 17 UAH |
| Tefor metformin | -- | -- |
| Glycometer | -- | -- |
| Glycomet SR | -- | -- |
| Forthine | 37 rub | -- |
| Metformin Canon metformin, ovidone K 90, starch ea poone, crospovidone, magnesium stearate, talc | 26 rub | -- |
| Insuffor metformin hydrochloride | -- | 25 UAH |
| Diaformin SR metformin | -- | 18 UAH |
| Mepharmil Metformin | -- | 13 UAH |
| Metformin Farmland Metformin | -- | -- |
Lethathamo le ka holimo la li-analogues tsa lithethefatsi, tse bonts'ang Likhetho tsa Metformin-Teva, e loketse haholo hobane e na le sebopeho se tšoanang sa lintho tse sebetsang ebile e lumellana ho latela sesupo sa tšebeliso
Moetso o fapaneng o kanna oa lumellana ho bonts'a mokhoa le mokhoa oa ts'ebeliso
| Sehlooho | Theko ho la Russia | Theko Ukraine |
|---|---|---|
| Rosiglitazone e sebetsang, metformin hydrochloride | -- | -- |
| Glibenclamide Glibenclamide | 30 rub | 7 UAH |
| Maninyl Glibenclamide | 54 rub | 37 UAH |
| Glibenclamide-Health Glibenclamide | -- | 12 UAH |
| Glyurenorm glycidone | 94 rub | 43 UAH |
| Bisogamma Glyclazide | 91 rub | 182 UAH |
| Glidiab Glyclazide | 100 rub | 170 UAH |
| Diabeteson MR | -- | 92 UAH |
| Diagnizide mr Gliclazide | -- | 15 UAH |
| Glidia MV Gliclazide | -- | -- |
| Glykinorm Gliclazide | -- | -- |
| Gliclazide Gliclazide | 231 rub | 57 UAH |
| Glyclazide 30 MV-Indar Glyclazide | -- | -- |
| Glyclazide-Health Gliclazide | -- | 36 UAH |
| Glioral Glyclazide | -- | -- |
| Lekola Gliclazide | -- | 14 UAH |
| Diazide MV Gliclazide | -- | 46 UAH |
| Osliklid Gliclazide | -- | 68 UAH |
| Diadeon gliclazide | -- | -- |
| Glyclazide MV Gliclazide | 4 rub | -- |
| Amaril | 27 rub | 4 UAH |
| Glemaz glimepiride | -- | -- |
| Glian glimepiride | -- | 77 UAH |
| Glimepiride Glyride | -- | 149 UAH |
| Glimepiride diapiride | -- | 23 UAH |
| Aletare | -- | 12 UAH |
| Glimax glimepiride | -- | 35 UAH |
| Glimepiride-Lugal glimepiride | -- | 69 UAH |
| Clay glimepiride | -- | 66 UAH |
| Diabrex glimepiride | -- | 142 UAH |
| Meglimide glimepiride | -- | -- |
| Melpamide Glimepiride | -- | 84 UAH |
| Perinel glimepiride | -- | -- |
| Glempid | -- | -- |
| Ke thabo | -- | -- |
| Glimepiride glimepiride | 27 rub | 42 UAH |
| Glimepiride-teva glimepiride | -- | 57 UAH |
| Glimepiride Canon glimepiride | 50 rub | -- |
| Glimepiride Pharmacyard glimepiride | -- | -- |
| Dimaril glimepiride | -- | 21 UAH |
| Glamepiride diamerid | 2 rub | -- |
| Amaryl M Limepiride Micronized, Metformin Hydrochloride | 856 rub | 40 UAH |
| Glibomet glibenclamide, metformin | 257 rub | 101 UAH |
| Glucovans glibenclamide, metformin | 34 rub | 8 UAH |
| Dianorm-m Glyclazide, Metformin | -- | 115 UAH |
| Dibizid-m glipizide, metformin | -- | 30 UAH |
| Douglimax glimepiride, metformin | -- | 44 UAH |
| Duotrol glibenclamide, metformin | -- | -- |
| Gluconorm | 45 rub | -- |
| Glibofor metformin hydrochloride, glibenclamide | -- | 16 UAH |
| Avandamet | -- | -- |
| Avandaglim | -- | -- |
| Janumet metformin, sitagliptin | 9 rub | 1 UAH |
| Velmetia metformin, sitagliptin | 6026 rub | -- |
| Galvus Met vildagliptin, metformin | 259 rub | 1195 UAH |
| Tripride glimepiride, metformin, pioglitazone | -- | 83 UAH |
| Comboglize XR metformin, saxagliptin | -- | 424 UAH |
| Comboglyz Prolong metformin, saxagliptin | 130 rub | -- |
| Gentadueto linagliptin, metformin | -- | -- |
| Vipdomet metformin, alogliptin | 55 rub | 1750 UAH |
| Sinjardi empagliflozin, metformin hydrochloride | 240 rub | -- |
| Voglibose Oxide | -- | 21 UAH |
| Glutazone pioglitazone | -- | 66 UAH |
| Dropia Sanovel pioglitazone | -- | -- |
| Januvia sitagliptin | 1369 rub | 277 UAH |
| Galvus vildagliptin | 245 rub | 895 UAH |
| Onglisa saxagliptin | 1472 rub | 48 UAH |
| Nesina alogliptin | -- | -- |
| Vipidia alogliptin | 350 rub | 1250 UAH |
| Trazhenta linagliptin | 89 rub | 1434 UAH |
| Lixumia lixisenatide | -- | 2498 UAH |
| Gum ea guar | 9950 rub | 24 UAH |
| Insvada repaglinide | -- | -- |
| Novonorm Repaglinide | 30 rub | 90 UAH |
| Repodiab Repaglinide | -- | -- |
| Baeta Exenatide | 150 rub | 4600 UAH |
| Baeta Long Exenatide | 10248 rub | -- |
| Viktoza liraglutide | 8823 rub | 2900 UAH |
| Saxenda liraglutide | 1374 rub | 13773 UAH |
| Forksiga Dapagliflozin | -- | 18 UAH |
| Forsiga Dapagliflozin | 12 rub | 3200 UAH |
| Invocana canagliflozin | 13 rub | 3200 UAH |
| Jardins Empagliflozin | 222 rub | 566 UAH |
| Trulicity Dulaglutide | 115 rub | -- |
U ka fumana analogue e theko e tlaase ea moriana o theko e phahameng?
Ho fumana analogue e theko e phahameng ea moriana, mofuta o tšoanang kapa oa mantsoe, pele ho tsohle re khothaletsa ho ela hloko sebopeho, e leng lintho le lipontšo tse tšoanang tse sebetsang. Metsoako e tšoanang ea lithethefatsi e tla bonts'a hore lithethefatsi li tsamaisana le lithethefatsi, li ka lekana meriana kapa li ka etsa meriana. Leha ho le joalo, u se ke oa lebala ka likarolo tse sa sebetseng tsa lithethefatsi tse tšoanang, tse ka amang polokeho le ts'ebetso. Se ke la lebala ka litaelo tsa lingaka, ho itlama ho ka lematsa bophelo ba hau, ka hona, etela ngaka ea hau kamehla pele u sebelisa meriana leha e le efe.
Tlhahiso ea Metformin-Teva
Ketso ea pharmacological
Metformin e thibela tsoekere e maling, e fokotsa ho kenella ha tsoekere maling, e ntlafatsa tšebeliso ea tsoekere, hape e eketsa kutloisiso ea lithane ho insulin. Ha e ame secretion ea insulin ke lisele tsa beta tsa manyeme, ha e bake karabelo ea hypoglycemic. Fokotsa boemo ba triglycerides le lioprotein tse tlaase maling. E tsitsisa kapa e theola boima ba 'mele. E na le phello ea fibrinolytic ka lebaka la khatello ea inhibitor ea tisy ea plasminogen activator.
Mofumahali
Kamora ho tsamaisoa ka molomo, metformin e nkuoa ho tsoa mokokotlong oa lijo. Bioavailability kamora ho nka tekanyetso e tloaelehileng ke 50-60%. Cmax e plasma ea mali e fihlella lihora tse 2,5 ka mor'a ho kenella. Ha e lumellane le liprotheine tsa plasma. E bokellana ka har'a litsoelesa tse qhekellang, mesifa, sebete le liphio. E hloekisoa e sa fetoloe ke liphio. T1 / 2 ke lihora tse 9-12. Ka ts'ebetso ea renal e sa foleng, ho fumaneha ha lithethefatsi hoa khoneha.
Matšoao
- mofuta oa 2 oa lefu la tsoekere ntle le tloaelo ea ketoacidosis (haholoholo ho bakuli ba nang le botenya) ka ho se sebetse hantle kalafo ea ho ja.
- hammoho le insulin - mofuta oa lefu la tsoekere la mofuta oa 2, haholoholo le bonyane ba botenya, bo tsamaisanang le ho hanyetsa insulin.
Melemo ea litekanyetso
Tekanyo ea lithethefatsi e beoa ke ngaka ka bonngoe, ho latela boemo ba tsoekere maling.
Motsoako oa pele ke 500-1000 mg / letsatsi (matlapa a 1-2). Kamora matsatsi a 10-15, keketseho e tsoelang pele ea butle-butle ea tekanyetso e ka etsahala ho latela boemo ba tsoekere ea mali.
Tekanyo ea tlhokomelo ea moriana hangata e ba 1500-2000 mg / letsatsi. (Letlapa la 3-4.) Tekanyetso e phahameng ke 3000 mg / letsatsi (matlapa a 6).
Bakeng sa bakuli ba tsofetseng, tekanyetso ea letsatsi le letsatsi e khothalletsoang ha ea lokela ho feta 1 g (matlapa a 2).
Matlapa a Metformin a lokela ho nooa a felletse nakong ea lijo kapa hang ka mor'a lijo le metsi a mangata (khalase ea metsi). Ho fokotsa litla-morao tse tsoang mpeng ea gastrointestinal, tekanyetso ea letsatsi le letsatsi e lokela ho aroloa ka litekanyetso tse peli.
Ka lebaka la kotsi e eketsehileng ea lactic acidosis, lethal dose le lokela ho fokotsoa haeba ho na le mathata a tebileng a metabolic.
Litla-morao
Ho tsoa ho tsamaiso ea tšilo ea lijo: ho nyekeloa ke pelo, ho hlatsa, ho latsoa ka tšepe ka hanong, ho hloka takatso ea lijo, lets'ollo, lefutso, bohloko ba ka mpeng. Matšoao ana a tloaelehile haholo qalong ea kalafo 'me hangata a itsamaela a le mong. Matšoao ana a ka fokotsa ho khethoa ha anthocides, li-derivatives tsa atropine kapa antispasmodics.
Ho tloha lehlakoreng la metabolism: maemong a sa tloaelehang - lactic acidosis (e hloka ho khaotsa kalafo), ka kalafo ea nako e telele - hypovitaminosis B12 (malabsorption).
Ho tsoa lithong tsa hemopoietic: maemong a mang - anemia ea megaloblastic.
Ho tsoa tsamaisong ea endocrine: hypoglycemia.
Litla-morao:
Contraindication
- lefu la tsoekere ketoacidosis, lefu la tsoekere, leta,
- mosebetsi o sa sebetseng oa renal,
- mafu a a hlobaetsang le a nang le kotsi ea ts'ebetso ea ho tšoaroa ke masapo a methapo: ho omella (ka lets'ollo, ho hlatsa), feberu, mafu a tšoaetsanoang haholo, hypoxia (ho thothomela, sepsis, tšoaetso ea liphio, mafu a bronchopulmonary),
- lipontšo tse hlahisitsoeng ka mokhoa oa kliniki oa maloetse a hlobaetsang le a sa foleng a ka lebisang ho nts'etsopele ea tishu hypoxia (pelo kapa ho hloleha ho phefumoloha, infarction e mpe ea myocardial),
- lits'ebetso tse tebileng tsa ho buoa le ho tsoa likotsi (ha ho bontšoa kalafo ea insulin),
- ts'ebetso ea ho se sebetse hantle ha sebete,
- Joala bo sa feleng, chefo e matla ea joala,
- Sebelisa bonyane matsatsi a 2 pele le ka nako ea matsatsi a mabeli kamora ho etsa lithuto tsa radioisotope kapa x-ray ka kenyelletso ea li-iodine tse nang le phapang e mahareng,
- lactic acidosis (ho kenyeletsoa le nalane),
- ho latela mokhoa oa ho ja lijo tse nang le khalori e tlase (ka tlase ho 1000 cal / ka letsatsi),
- boimana
- nako ea kemolo,
- Hypersensitivity ho lithethefatsi.
Ha ho khothalletsoe ho sebelisa lithethefatsi ho batho ba lilemo tse fetang 60 ba etsang mosebetsi o boima oa 'mele, o amanang le kotsi e kholo ea ho ba le lactic acidosis ho bona.
Bokhachane le pelehi
Ha u rera ho ima, hammoho le nakong ea kemaro ha u ntse u nka Metformin, e lokela ho hlakoloa mme kalafo ea insulin e lokela ho fanoa. Kaha ha ho na data ea ho kenella ka lebeseng la matsoele, sethethefatsi sena se kopantsoe le ho anyesa. Haeba ho hlokahala ho sebelisa Metformip nakong ea matsoele, ho anyesa ho lokela ho emisoa.
Litaelo tse khethehileng
Nakong ea kalafo, ho hlokahala hore ho hlahlojoe ts'ebetso ea renal. Bonyane makhetlo a 2 ka selemo, hammoho le ponahalo ea myalgia, litaba tsa lactate tse ho plasma li lokela ho ikemisoa. Ntle le moo, hang ka mor'a likhoeli tse ling le tse ling tse tšeletseng ho hlokahala hore ho laoloe boemo ba "metabolinine" serum ea mali (haholoholo ho bakuli ba botsofaling). Metformin ha ea lokela ho khethoa haeba boemo ba "creatinine" maling bo phahame ho feta 135 μmol / L ho banna le 110 μmol / L ho basali.
Mohlomong ts'ebeliso ea lithethefatsi Metformin hammoho le litlamorao tsa sulfonylurea. Maemong ana, ho hlokahala haholo ho lekola maemo a tsoekere ea mali.
Lihora tse 48 pele le ka hare ho lihora tse 48 ka mor'a hore radiopaque (urography, iv angiography), o lokela ho emisa ho nka Metformin.
Haeba mokuli a na le ts'oaetso ea bronchopulmonary kapa lefu le tšoaetsanoang la litho tsa genitourinary, ngaka e tlang e lokela ho tsebisoa hanghang.
Nakong ea kalafo, o lokela ho khaotsa ho nka joala le lithethefatsi tse nang le ethanol. .
Tšusumetso ho bokhoni ba ho khanna makoloi le litsamaiso tsa taolo
Tšebeliso ea moriana ona ho monotherapy ha e ame bokhoni ba ho khanna makoloi le ho sebetsa ka methapo.
Ha Metformin e kopantsoe le baemeli ba bang ba hypoglycemic (li-sulfonylurea derivatives, insulin), maemo a hypoglycemic a ka hlaha moo bokhoni ba ho khanna makoloi le ho etsa lintho tse ling tse ka bang kotsi tse hlokang tlhokomelo e eketsehileng le karabelo e potlakileng ea psychomotor e senyehileng.
Bongata
Ka overdose ea Metformin, lactic acidosis e nang le sephetho se bolaeang e ka etsahala. Sesosa sa nts'etsopele ea lactic acidosis le eona e ka ba ho lutla ha moriana ka lebaka la ts'ebetso ea renal e sa sebetseng.
Matšoao a lactic acidosis: ho nyekeloa ke pelo, ho hlatsa, lets'ollo, ho fokotsa mocheso oa 'mele, bohloko ba ka mpeng, bohloko ba mesifa, nakong e tlang ho kanna ha eketsoa ho hema, ho tsekela, ho hloka kelello le ho holofala.
Phekolo : haeba ho na le lipontšo tsa lactic acidosis, kalafo e nang le Metformin e lokela ho emisoa hang-hang, mokuli o lokela ho kena sepetlele ka potlako mme, ha a se a lemohile hore a na le lactate, a tiisa tlhahlobo ea lefu. Mohato o sebetsang ka ho fetisisa oa ho tlosa lactate le metformin 'meleng ke hemodialysis. Phekolo ea matšoao le eona ea etsoa.
Ka kalafo e kopaneng le Metformin le sulfonylureas, hypoglycemia e ka hlaha.
Ho sebelisana le lithethefatsi
Tšebeliso e tšoanang ea danazol ha e khothalletsoe ho qoba sephetho sa hyperglycemic ea ho qetela. Haeba kalafo e nang le danazol e hlokahala mme kamora ho emisa ho emisa, ho lokisoa ha litekanyetso tsa metformin le iodine ho hlokahala ho laola boemo ba glycemia.
Motsoako o hlokang tlhokomelo e khethehileng: chlorpromazine - ha e nooa ka tekanyetso e kholo (100 mg / ka letsatsi) e eketsa glycemia, e fokotsa ho lokolloa ha insulin.
Ka kalafo ea li-antipsychotic le ka mor'a ho khaotsa ho nka mokhoa oa ho qetela, ho fetola litekanyetso tsa metformin ho hlokahala tlasa taolo ea boemo ba glycemia.
Ka ts'ebeliso e ts'oanang le sulfonylurea derivatives, acarbose, insulin, NSAIDs, li-inhibitors tsa MAO, oxetetracycline, li-inhibitors tsa ACE, li-derofatives tse tsoang ka hare, cyclophosphamide, li-blockers tsa qoqotho, li ka khona ho eketsa phello ea hypoglycemic ea metformin.
Ka tšebeliso e ts'oanang le corticosteroids, lithibela-pelehi tsa molomo, epinephrine, sympathomimetics, glucagon, lihomone tsa qoqotho, thiazide le loopture tsa loopt, derivatives ea phenothiazine, li-nicotinic acid derivatives, ho fokotseha hoa phello ea hypoglycemic ea metformin ho ka etsahala.
Cimetidine e liehisa ho felisoa ha metformin, e eketsang kotsi ea lactic acidosis.
Metformin e ka fokolisa phello ea li-anticoagulants (tse tsoang ho coumarin).
Ho itlopa joala ho eketsa kotsi ea ho ba le lactic acidosis nakong ea tahi e matla, haholo maemong a ho itima lijo kapa ho latela lijo tse nang le khalori e tlase, hammoho le ho hloleha ha sebete.
Lipehelo tsa Maemo a Phomolo ea meriana
Setlhare ke ngaka.
Lipehelo le maemo a polokelo
Boloka sebakeng se omileng se lefifi ka mocheso oa 15 ° ho isa ho 25 ° C.
Qoba hole le bana.
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