Ka 1930, Frey o ile a qala ho sebelisa trasilol kallikrein inactivator ka katleho ho phekola pancreatitis e hlobaetsang. Inhibitor ea pele e hloekisitsoeng ea pele e fumanoe ke M. Kunitz le J. H. Norlrop ka 1936 ho tsoa makhophong a liphoofolo.

Thepa e tloaelehileng ea li-inhibitors (litokisetso tsa antienzyme) ke bokhoni ba ho thibela ts'ebetso ea li-enzyme tsa proteinolytic ka ho theha mechini e tsitsitseng e sa sebetseng le bona. Ho fihla joale, ho se ho phatlalalitsoe mesebetsi e fetang 2 000 mabapi le tšebeliso ea litokisetso tsa antienzyme bakeng sa kalafo ea pancreatitis e mpe, ka bobeli tleliniking le tlhahlobong. Leha ho le joalo, ho ne ho se tumellano mabapi le bonnete ba ts'ebeliso ea ts'ebetso ea pathogenetic ea ts'ebeliso ea bona, ts'ebetso, litekanyetso, litsela tsa tsamaiso. Lingaka tse ngata li lumela hore tšebeliso ea li-inhibitors ha e fane ka phello, ha li bua ka taba ea hore litokisetso tsa thibelo, esita le ho litekanyetso tse kholo, ha li sitise ts'ebetso ea necrotic ka hara gland le para-pancreatic fiber. Ka mofuta o hlasimolohileng oa pancreatitis, tšebeliso ea trasilol le litokisetso tse ling tsa antienzyme ha li lokafatsoe ho tsoa kliniking le ponong ea moruo. Leha ho le joalo, ts'ebeliso ea li-inhibitors tsa proteinase ha ea lokela ho tloheloa ka ho felletseng.

Phihlelo ea lingaka tsa malapeng le tsa kantle ho naha li bonts'a hore protheine ea protheine ea inhibititi e thibelang kinin le ho etsoa ha methapo ea kutlo ka ho inactivating trypsin, kallikrein, chymotrypsin le plasmin. Re hlokometse hore ka thuso ea li-inhibitors hangata ho khonahala ho tlosa bakuli ho makala, toxemia, ho ntlafatsa maemo a akaretsang le ho etsa hore litekanyetso tse ling tsa biochemical. Ntle le moo, hoa tsebahala hore litokisetso tsa antifterment li thibela esterase, mosebetsi oa protheine le kininogenase ea plasma le pancreatic kallikrein.

Kamora ho tsamaisoa ha litokisetso tsa antienzyme ho mokuli bakeng sa metsotso e 5, mefuta e sa sebetseng ea inhibitor-enzyme (Werle, 1963). Metsotso e 60 kamora ho kenella, litaba tsa inhibitor maling li fokotsehile haholo, ha ka nako ena liphio li na le hofeta ho feta 50% ea inhibitor e kentsoeng. Thibelo e felletseng ea enzyme e bonoa feela moo ho nang le inhibitor e feteletseng.

Ho ile ha qaloa ka teko ea hore liperesente tse 98 tsa li-antienzymes ka sebopeho se rarahaneng li hlakoloa ho tsoa 'meleng ke liphio. Ho lumeloa hore trasilol le analogees inhibit fibrinolysis, li thibela tšebetso ea kininogenin (kallikrein) ka sethaleng sa gland, li thibela ts'ebetso e akaretsang ea metabolism ea gland parenchyma, e ama ka matla ts'ebetso ea miccirculation le oksijene ea li-tishu, inhibit elastase, chymotrypsin ka ho toba ka har'a li-pancreas. Bophelo ba halofo ea trasilol, kontrikal le liprotheine tse ling tse tsoang maling ke lihora tse peli. Ka hona, litokisetso tsa antienzyme li tlameha ho fanoa khafetsa. Lits'ebetso lipakeng tsa tsamaiso ha lia lokela ho feta lihora tse 3, mme boemo ba inactivator bo lokela ho lula bo phahame ho feta boemo ba li-enzyme tsa protein. Mabapi le sena, tsamaiso ea nako e telele ea litekanyetso tse nyane tsa li-inhibitors ha e na thuso ebile ha e na thuso. Tekanyetso ea letsatsi le letsatsi ea inhibitors e lokela ho ikemisetsa ho nka halofo ea bophelo ba bona bo tsoa maling (lihora tse peli). Palo e kholo ea litokisetso tsa antienzyme e lokela ho fanoa ka letsatsi la pele la lefu lena.

Ho ea ka datha ea rona (MayatC. et al., 1976), e ipapisitse le tlhahlobo ea liphetho tsa kalafo ea bakuli ba 107, tsamaiso e kenelletseng ea litokisetso tsa antienzyme esita le ka tekanyetso e kholo ha e emise ho qaleha ha pancreatic necrosis. Ho bohlokoa ho hlokomela hore katleho ea li-inhibitors e khetholloa ke hore na ho fetile nako e kae ho tloha ho qala ha lefu lena ho fihlela nako ea ts'ebeliso le litekanyetso tsa moriana tse laetsoeng. Ho latela lingaka tse ngata, litokisetso tsa antienzyme li lokela ho tsamaisoa ka lihora tse 6 tsa pele ho tloha lefu le qala. Liphetho tse khothatsang li eketsehileng li fumanoe ka kenyelletso ea li-inhibitors ka mokokotlong oa celiac. Bolokov BC (1983) e khothaletsa tsamaiso e hlophisitsoeng ea litokisetso tsa antienzyme ka nako ea lihora tse 3-4.

G.P. Titova (1989) o fumane hore liprotheine tse thibelang pancreatitis ea liteko ha li fokotse boholo ba tšenyo ea tšoelesa ebile ha li felise mathata a hemorheological a lehae.

Ts'ebetsong ea bongaka, li-inhibitors tse latelang li atile haholo: Contrical, Trasilol (Jeremane), Gordox (Hungary), Pantripin (Russia), Tsalol (Italy).

Contrical ke lithethefatsi tse arohaneng le matšoele a likhomo. E thibela ts'ebetso ea trypsin, kallikrein, plasmin. E sebelisoa kahare le kahare ho likarolo tsa antitrypsin (1 unit inactivates 6 μg ea trypsin). Tekanyetso e le 'ngoe ea pancreatitis e hlobaetsang ke li-unit tse 20,000, letsatsi le letsatsi - li-unit tse 60,000. Nako ea kalafo ke li-unit tse 500,000-700,000. Setlhare se ka sebelisoa ka ho khetheha ka ho chorisa parapancreatic fiber.

Trasilol e fumanoa litšoeleng tsa liphoofolo tse mongobo. Moriba o thibela tšebetso ea plasmin, kallikrein, trypsin le li-enzyme tse ling tsa protein. Ho feta moo, e ama trypsin e sebetsang ka makhetlo a 4 ho feta ts'ebetso ea kallikrein. Karolo ea halofo ea potoloho ea mali maling ke metsotso e 150. E sebelisoa ka tekanyetso: Yuniti ea 50,000-75,000, maemong a tebileng - diyuniti tse ka bang 100,000, e tsamaisoa ka mokhoa o ts'oanelang ho 250-500 ml ea tharollo ea glucose ea 5%. Bakeng sa nako ea kalafo - 400000-500000 unit. Nako ea kalafo ea antienzyme hangata e fela ka letsatsi la 7-10.

Gordox, joalo ka trasilol, e fumanoa litšoeleng tsa liphoofolo tse itsoelang feela. Etsa kopo kahare. Ha e le lethal dose la pele, li-unit tse 500,000 li lokela ho tsamaisoa butle butle, ebe li-unit tse 50 000 ka hora tse ling le tse ling. Matsatsing a latelang ka mor'a ntlafatso, tekanyetso ea letsatsi le letsatsi e ka fokotsoa butle-butle hore e be likarolo tsa 300,000-500,000.

Pantripin e fumanoa ho manyeme a liphoofolo. Yuniti e le 'ngoe ea eona e tšoana le 800 IU ea trasilol. Sekhahla sa letsatsi le letsatsi ke li-unit tsa 300, ka mefuta e matla - ho fihla ho li-unit tsa 400-500 ka nako.

Tsalol e fumanoa ho tsoa metsong ea likhomo tsa parotid. Tekanyetso e le 'ngoe - li-unit tsa 25,000, letsatsi le letsatsi - li-unit tse 50 000. Kenya kahare. Nako ea kalafo ke li-unit tse 300000-400000.

Protease inhibitors e ka kenngoa ka mokotleng oa ho hlatsoa lintho, ho khutlisetsa nako nakong ea ts'ebetso ea bongaka.

Liphephetso ka tšebeliso ea li-inhibitors tsa protease li fumaneha seoelo. Ho na le litšupiso tse ling tse mabapi le ho se sebetsane le phello ea letlalo le ho holofala ha letlalo, nts'etsopele ea thrombophlebitis haufi le methapo. P. Kyrle (1962) o hlokometse nts'etsopele ea li-pseudocysts le abscesses.

Ha o fana ka kalafo ea thibelo ho bakuli ba nang le pancreatitis e hlobaetsang, ho lokela ho lateloa melao-motheo e latelang: 1) ho nahanisisa ka nako ea ts'oaetso (tlhahlobo ea bongaka ea pelehi, ho sepetla le kalafo), 2) ho nahanisisa ka mekhoa ea bongaka le ea morphological ea pancreatitis e mpe, 3) tšebeliso ea litekanyetso tse phahameng tsa litokisetso tsa antienzyme, 4) ts'ebeliso ea lintho tse kopaneng mekhoa ea tsamaiso ea li-inhibitors (Savelyev BC et al., 1976).

Tsela e kenelletseng ea tsamaiso ea li-protease inhibitors ha e lumelle ho ba le bongata bo boholo ba bona manyetsong. Bakeng sa ho ntlafatsa liphetho tsa kalafo tsa BC pancreatitis Savliev (1976), Yu.A. Nesterenko et al. (1978) khothaletsa tsamaiso ea li-proteinase inhibitors intra-aortic kapa ka ho khetha li-celiac artery ho latela Seldinger-Edman. Tleliniking, mokhoa ona o ile oa sebelisoa pele ke K.N. Grozinger le Wenz (1965). Ha e ratoe hona joale.

B.C. Briskin et al. (1989) o entse kalafo ea intra-aortic ho bakuli ba 92 ba nang le pancreatitis e matla. Ho phekola kutu ea "celiac" kapa artery e phahameng ea mesenteric, hangata methapo ea methapo ka bobeli. Motsoako oa metsoako ea bongaka o kenyellelitsoe: gelatin, polyglucin, albin, hammoho le no-spa, papaverine, ts'ehetso, lithibela-mafu, gordox (600 000-800 000 ka letsatsi). Bophahamo ba infusion bo ne bo itšetleha ka BCC le ho tloha ho 2000 ho isa ho 3500 ml ka letsatsi. Haeba ho hlokahala, mokelikeli o mong o eketsehileng oa lithethefatsi le lithethefatsi li ne li fanoa ka methapo. Bangoli ba lumela hore ho ata ha ts'ebetso ea ho ruruha ka har'a lithane tsa ho khutlisa ho ka emisoa ka ho kenyelletsa metsi le lithethefatsi ka nako e le ngoe liseleng tse peli.

V.P. Grigoriev (1978) bakeng sa ts'ebetso ea li-inhibitors o kentse gland e nepahetseng ea gastro-omental. Monyetla oa tsamaiso e ngotsoeng e nang le liprotheine tse thibelang liproteine ​​ke hore, ntle le ts'ebetso e tobileng ho manyeme, e u lumella ho feta lits'oants'o tsa tlhaho tsa tlhaho - sebete le matšoafo.

Ka ts'ebetso ea bongaka, li-inhibitors tsa protheine ha li e-so sebelisoe haholo bakeng sa mabaka a moruo, hape le ka lebaka la ho se sebetse hantle ha li-pancreatic necrosis. Leha ho le joalo, ka toxemia e matla, kalafo e kopaneng le cytostatics le protease inhibitors e ea eletsoa, ​​e o lumellang ho thibela ts'ebetso ka botlalo le gland ka boeona le ho thibela li-enzyme tse potileng maling, nymph le tishu.

Pancreatitis meriana

Re lokela ho hopola hore pancreatitis e hlobaetsang e bua ka maemo a potlakileng, 'me kalafo ea eona e etsoa feela sepetleleng sa bongaka, moo bakuli, maemong a mangata, ba kenang sepetlele ka potlako ke sehlopha sa maemo a tšohanyetso. Maemong a tebileng, a hlahang ho bakuli ba 20-25%, ho ka bonoa boemo bo haufi le lefu la ka mpeng, mme ha ho ka ba le tahlehelo e matla ea metsi ka lebaka la ho hlatsa, le hypovolemia.

Ka hona, lithethefatsi bakeng sa pancreatitis e hlobaetsang, qalong, e lokela ho kokobetsa bohloko bo boholo, e tsamaisane le ho nyekeloa ke pelo, ho hlatsa, khatello e phahameng ea pelo le ho theoha ha khatello ea mali, hape le ho khutlisetsa tekano ea motlakase oa 'mele' meleng. Bohloko bo khutlisoa ke tsamaiso ea batsoali ea li-analgesics (Novocaine e nang le glucose, Analgin, Ketanov) kapa antispasmodics: No-shpa, Papaverine hydrochloride, Platifillin hydroartate, Metacin kapa Ganglefen hydrochloride.

Ka nako e ts'oanang, ho hlaphoheloa ha mokelikeli le ho tsitsisa ha hemodynamic ho etsoa: sekhahla se tšeloa khafetsa bakeng sa pancreatitis - ka letsoai, tsoekere le likarolo tse ling tse tšehetsang mosebetsi oa litsamaiso le litho tse fapaneng. Matšoao a karabelo ea ts'ebetso ea ho ruruha, ho sepsis le ho se sebetse hantle ha litho tse ngata ho tsoa ho bakuli ba nang le pancreatitis e matla ea perekisi ka lebaka la hore li-enzymes tsa "pancreatic" tse jang karolo ea litho tsa eona tsa lisele li tsoa.

Ka hona, mehato ea tlhokomelo e matla e kopantsoe le thibelo ea ts'oaetso ea li-pancreatic tis tse amehang kapa ntoa ea ho loants'oa tšoaetso ea baktheria, 'me meriana e thibelang likokoana-hloko e sebelisoa gastroenterology ho rarolla bothata bona (hangata, ena ke Amoxiclav kapa cephalosporins ea boraro). Likarolong tsa ts'ebeliso ea bona gastroenterology ea bana, bona - Pancreatitis e hlobaetsang le ho bana

Mosebetsi o mong ke ho hatella tšebetso ea lekunutu la tšoelesa hore e se ke ea fokotsa mejaro ea eona ka hohle kamoo ho ka khonehang, empa hape le ho emisa ts'enyeho e ke keng ea fetoloa ea lisele, e lebisang ho pancreatic necrosis. Bakeng sa sena, ho na le lithethefatsi tse thibelang ho kopana ha li-enzymes tsa pancreatic. Mabitso a bona a sehlooho:

• Aprotinin (synonyms - Kontrikal, Gordoks, Traskolan),
• Octreotide (Octrid, Octretex, Sandostatin, Seraxtal).

Joaloka molao, li sebelisetsoa feela pancreatitis e matla haholo ho batho ba baholo. Bala haholoanyane ka bona ka tlase.

Mekhoa ea kalafo ea kalafo e sa foleng ea pancreatitis

Ntlha ea bohlokoa ka ho fetisisa, e kenyeletsang mokhoa oa kalafo oa pancreatitis le lithethefatsi, ke ho thibela tšebetso e sebetsang ea manyeme, ke hore, ho fokotsa tlhahiso ea li-enzyme tsa eona. Ho amoheloa ka kakaretso hore lisele tsa gland parenchyma li senyehile ke liprotheine tse entsoeng ke eona, 'me tšenyo e qalisoa liseleng tsa makhopho kamora ho kenella pele ho nako ea ts'ebetso ea li-enzyme tsa ho hlohlona.

Ka mofuta o sa foleng oa lefu lena, Pirenzepine (Gastrocepin) kapa Profinia bromide (Riabal) e ka sebelisoa ho fokotsa tlhahiso ea li-enzyme tsa protein. Lithethefatsi tsena li boetse li laeloa ho eketsa pancreatitis: haeba mokuli a kena sepetlele, Pirenzepine e sebelisoa ka mokhoa oa botsoali.

Boemo ba khaello ea li-enzyme tsa "pancreatic" tsa tlhaho li amahanngoa le ho ruruha ho sa feleng le tšenyo ea lisele tsa sephiri tsa manyeme. Ho e koahela, gastroenterologists e fana ka litokisetso tsa enzyme tse nang le liprotheine (li-protein tse arohanang), amylase (bakeng sa hydrolysis ea lik'habohaedreite tse rarahaneng) le lipase (e le hore 'mele o khone ho monya mafura). Tsena li kenyelletsa Pancreatin, e nang le mabitso a mangata a khoebo: Pancitrate, Pancreasim, Penzital, Mikrazim, Creon, Mezim, Gastenorm forte, Vestal, Hermitage, jj. Ntle le pancreatitis, matšoao a ts'ebeliso ea li-enzyme a kenyelletsa mathata le sistimi ea tšilo ea li-etiology tse fapaneng, dyspepsia , flatulence, cystic fibrosis, liphoso tsa phepo e nepahetseng.

Bakeng sa ho hatella tlhahiso ea hydrochloric acid ka mpeng, tlhahiso e eketsehileng e hlahisang motsoako oa lero la pancreatic, mohlaleng oa kalafo. pancreatitis e sa foleng lithethefatsi tsa lihlopha tse ling tse tharo tsa pharmacological li hlahisoa:

• li-antihistamines tsa H2 tsa antisecretory: Ranitidine (Ranigast, Atzilok, Zantak, jj.) kapa Famotidine (Pepsidin, Kvamatel, Gastrosidin),
• li-inhibitors tsa enzyme hydrogen-potasiamo ATPase (pampu ea proton): Omeprzazol (Omez, Gastrozole, Promez), Rabeprazole kapa Lansoprol (Lanzol, Clatinol, jj.),
• li-antacid tse nang le aluminium le hydroxides ea magnesium - Almagel (Alumag, Gastratsid, Maaloks), e emisang acid e ka mpeng.

Mokhoa oa ts'ebetso, mokhoa oa ho lokolla, mokhoa oa kopo le tekanyetso le litšoaneleho tse ling tsa pharmacological tsa meriana ea lihlopha tsena tse tharo li hlalositsoe ka botlalo linthong tse ling - Lipilisi tsa mala a ka mpeng

Mabapi le meriana efe e hlokahalang bakeng sa pancreatitis ho bana, le ka likarolo tsa ts'ebeliso ea bona bongoaneng, bala sengoloa - Phekolo ea pancreatitis e sa foleng

Litlhare tsa pancreatitis, tse thibelang tlhahiso ea li-enzymes tsa "pancreatic" (Aprotinin, Octreotide, Pirenzepine, Prifiny bromide) le ho etsa bofokoli ba tsona bo hlahang ka mor'a moo (Pancreatin), bo tšohloa ka botlalo ka tlase.

Tšebeliso ea li-inhibitors tsa liprotheine bakeng sa kalafo ea manyeme

Ka pancreatitis, ts'ebetso ea liprotheine e lebisa ho ruruheng ea setho le nts'etsopele ea libaka tsa necrotic.

Ho thibela lits'ebetso tse joalo tsa ts'oaetso, setsebi se khetha Contrical, Trasilol, Gordoks kapa Antagozan. Tšebeliso ea lithethefatsi tsena bakeng sa tsamaiso ea methapo e bohlokoa ka letsatsi la pele la pancreatitis e hlobaetsang.

Mefuta ea Enzymes ea Pancreatic

Mosebetsi o ka sehloohong oa manyeme ke ho etsa mesebetsi ea endocrine (ka hare) le exocrine (kantle). Ts'ebetso ea Endocrine e na le tlhahiso ea lihormone - "insulin", e theolang tsoekere le glucagon, e thusang ho hlahisa tsoekere maling.

Ts'ebetso ea exocrine ea manyeme ke ho hlahisa li-enzyme tse khethehileng (li-enzyme) tsa ho ja lijo. Li lokela ho aroloa ka lihlopha tse 'maloa - lipolytiki, amylolytic le li-enzyme tsa protein. A re ke re hlahlobeng ka botlalo leseli ka leng.

Li-enzyme tsa lipolytic. Sehlopha sena se ikarabella bakeng sa ho phatloha ha mafura ho mafura acid le glycerol. Prolipase ke enzyme e sa sebetseng ea lipase eo, ha e kena ka har'a duodenum, e kopana le colipase.

Ho qala ha lipase ho etsahala ka bongata ba letsoai la bile le trypsin. Ho phatloha ha likarolo tsa lipolytic ho etsoa ka lihora tse 7-14. Li-glomeruli tsa Renal li ikarabella bakeng sa ho filtara ha tsona: li khothalletsa ho monya ha lipase ka sebopeho sa lisele, ka hona likarolo tsa likarolo tsa lipolytic ha li fumanoe ka moroto. Lintho tse tšoanang le lipase li boetse li hlahisoa ke sebete, matšoafo le mala.

Li-enzyme tsa Amylolytic. Ho na le mefuta e 'maloa - alpha, beta le gamma amylase.Sehlopha sena sa li-enzyme se boetse se bitsoa starch. Ts'ebetsong ea tšilo ea lijo, ke alpha-amylase feela e amehang.

E boetse e hlahisoa ka tekanyo e nyane ke litšoelesa tse nang le mongobo, haholo ha e hlafuna lijo. Ka hona, re utloa tatso e monate kamora moo re hlafuna lijo tse halikiloeng - raese kapa litapole tse khotliloeng. Ka lebaka la amylase, ts'ebetso ea ho ts'oaroa ha starch le lik'habohaedreite tse ling tse rarahaneng li fetoha bonolo.

Li-enzyme tsa Proteolytic. Mosebetsi oa mantlha oa sehlopha sena ke ho phatloha ha liprotheine. Li-enzyme tsa Proteolytic li kenya letsoho ho fokotseheng ha li-amino acid tse tlamang tse fumanehang ka har'a peptides le liprotheine. Ho na le mefuta e 'meli e fapaneng ea protheine ho lero la pancreatic:

1. Peptidase, kapa exopeptidase, e ikarabellang bakeng sa hydrolysis ea metsoako ea kantle ea li-peptide.
2. Proteinase, kapa endopeptidase, e felisang metsoako e ka hare ea li-peptide.

Ka hona, lipase, amylase le proteinase li etsa lero la pancreatic, leo ha le kena ka duodenum, le qhekellang limolek'hule tse thata ho kena metsong e bonolo.

Lisosa le matšoao a pancreatitis

Ho motho ea phetseng hantle, ts'ebetso ea li-enzymes tsa pancreatic e etsahala ka duodenum.

Haeba ts'ebetso ea amylase, proteinase le lipase e qala ho manyeme ka boeona, re ka bua ka ho hloleha ha setho.

Pancreatitis e utloisisoa e le motsoako oa syndromes le maloetse a tsamaeang le ts'ebetso ea li-enzymes ka har'a gland, e lebisang ts'ebetsong ea "ho ikenya". Ka lebaka leo, ha ba kene ka har'a duodenum, mme tšilo ea lijo e a khathatseha.

Ho na le mabaka a 'maloa a lebisang ts'ebetsong e joalo ea pathological:

• khafetsa ho noa
• ho sitoa ho latela lijo tse nang le phepo e nepahetseng.
• tšebeliso e feteletseng ea lijo tse halikiloeng le tse mafura,
• ho ja lijo tse matlafatsang ka mor'a ho ja ka thata kapa ho itima lijo,
• ho ja ka mokhoa o sa laoleheng oa meriana e itseng
• tsamaiso ea tšilo ea lijo
• pathology ea tlhaho e tšoaetsanoang.

Ka ts'ebetso ea li-enzymes ka har'a manyeme, ho ruruha ho etsahala: e eketseha ka boholo, 'me libaka tsa necrotic li hlaha. Ts'ebetso e joalo e ke ke ea ba sesoeu, ho feta moo, ho na le tlolo ea mokhoa oa "gastrointestinal".

Ka khaello ea li-enzymes tsa pancreatic ka duodenum le ho ruruha ha manyeme, matšoao a latelang a bonoa:

1. Bohloko ho hypochondrium ea leqele, hangata ea mofuta oa shingles.
2. Phokotso ea bohlokoa ea bokooa, malaise le bofokoli ka kakaretso.
3. Dyspeptic disorder - ho thunya, ho nyekeloa kapa ho hlatsa, ho hloka takatso ea lijo, setofo se holofetseng.

Matšoao a lefu lena a ka fapana le ho haella ha enke e itseng:

• Khaello ea Amylase e lebisa ho letšollo, khaello ea livithamini, ho fokotsa boima ba 'mele. Metsoako e fetoha metsi, le likaroloana tse sa koaeloang tsa lijo li teng ka ho eona.
• Lenane le sa lekaneng la lipase le roalang mafura le baka steatorrhea - keketseho ea palo ea mafura setulong. Ka pancreatitis, metsamao ea "bowel" e fetoha mosehla kapa 'mala oa lamunu, motsoako oa mucus o bonoa ho bona.
• Ka lebaka la khaello ea protheine, metsoako ea protheine e sa tsejoeng e fumaneha ka mantle. Letšoao le nang le tšobotsi ke nts'etsopele ea phokolo ea mali.

Haeba motho a hlokomela lipontšo tse joalo, o lokela ho batla thuso ea bongaka kapele kamoo ho ka khonehang. Ngaka e tla u fa lengolo la liteko le kalafo e lekaneng.

Natural Pancreatic Enzyme Inhibitors

Mmele ha o hlahise feela lintho tsa enzymatic tse tlatsetsang ho phatloheng ha limolek'hule tse rarahaneng, empa hape le li-inhibitors tsa secretion ea pancreatic, i.e. dikarolo tse thibelang tlhahiso e feteletseng ya lero la pancreatic.

Li-block tsa enzyme li kenyelletsa pancreatic polypeptide (PPP), YY peptide, somatostatin, glucagon ea pancreatic, pancreastatin le neuropeptides.

Lihlekehleke tsa Langerhans, tse fumanehang mohatong oa manyeme, li hlahisa lihormone tse khethehileng, PPP, e thibelang tlhahiso ea metsi, li-enzyme le bicarbonate. E boetse e thibela tlhahiso ea acetylcholine.

Secretion ea PPP e eketseha maemong a joalo:

1. ka ho fepa ka kelello kapa ho ja lijo,
2. kamora ho hlohlelletsa methapo ea botšehali,
3. ka duodenal acidization,
4. ha e pepesetsoa gastrin le gastrin-peptide,
5. ha ho pepesoa lekunutu, cholecystokinin le VIP.

The distal ileum le kolone e ntša Yept peptide hang ha mafura a kena ka har'a tšilo ea lijo. Peptide ena e thusa ho fokotsa tsitsipano ea litšoelesa litlamorao tsa cholecystokinin le secretin.

Lisele tsa pancreatic D le membrane ea mucous ea tšilo ea lijo e hlahisa somatostatin. Hormone ena e thibela tlhahiso ea li-enzyme le bicarbonate. Sisteme ea methapo ea kutlo e nka karolo ho hlahiseng somatostatin, hang ha mafura le amino acid e tsoa lijong.

Li-inhibitors tse ling tsa pancreatic li emeloa ke lihormone tse joalo:

• Pancreatic glucagon, e emisang tlhahiso ea maro, li-bicarbonate le enzymes.
• Pancreastatin, e thibelang ho lokolloa ha acetylcholine. E hlahisoa qetellong ea methapo ea botsana.
• Neuropeptides, e nang le calcitonin-information peptide (e susumetsa somatostatin) le enkephalins (fokotsa tlhahiso ea acetylcholine).

Ka lits'ebetso tse senyang ts'ebetsong ea botšehali, secretion ea li-pancreatic enzyme inhibitors e kanna ea senyeha, ka hona o tlameha ho sebelisa meriana.

Melao-motheo ea kalafo bakeng sa pancreatitis

Likarolo tse peli tsa bohlokoa tsa kalafo e sebetsang bakeng sa lefu lena ke lijo le meriana. Mokhoa oa phekolo o ntlafatsoa ka bonngoe ho latela botebo ba lefu lena le tšenyo ea manyeme.

Lijo tse khethehileng tsa "pancreatitis" li thehiloe ho ja No. 5 ho latela Pevzner. E felisa tšebeliso e feteletseng ea lijo tse nang le lik'habohaedreite le lijo tse mafura hape e reretsoe ho ja lijo tsa protheine.

Ka ho qala ha pancreatitis e sa foleng, ho laetsoe matsatsi a 3-4 a ho itima lijo. Ka nako ena, o tlameha ho hana ho ja le ho noa metsi a futhumetseng a letsoai haholo, mohlala, Borjomi.

Kamora ho bolaoa ke tlala le pancreatitis, lijo tse bolokiloeng li hlahisoa lijong tse ke keng tsa imetsa tsamaiso ea lijo. Bakuli ba nang le pancreatitis ba lumelloa ho sebelisa:

• mefuta ea lijo le nama ea tlhapi,
• sopho ea meroho le moroho o hloiloeng,
• mahobe le libiskiti tsa maobane,
• skim lihlahisoa tsa lebese,
• litholoana tse ncha, litlama le meroho,
• lijo-thollo tse halikiloeng ka metsing kapa lebese le senang mafura,
• mahe ka palo e fokolang,
• rosehip moro, mahe a linotsi kapa jeme (e lekantsoe).

Ka ho ruruha ha manyeme, ho bohlokoa ho hana lijo tse eketsang tšilo ea lijo:

1. Lihlahisoa tsa chokolete, lijo-thollo, likuku.
2. Bohobe bo bocha.
3. Lijo tse halikiloeng.
4. Ho boloka, ho tsubelletse nama le li-pickles.
5. Lijo tse mafura le tlhapi.
6. Lihlahisoa tsa lebese tse mafura.
7. Lino tse khabisitsoeng ka khalase.
8. Linoko.
9. Mapheo a ruileng.
10. Ho na le mahe a mangata.
11. Tee e matla le kofi.
12. Sosebelisoa.
13. Li-legum le tamati.

Ka ho eketsoa ke pancreatitis e sa foleng, ho bohlokoa ho latela boroko ba ho robala.

Moriana bakeng sa makhopho a kenyelletsa ts'ebeliso ea:

• enhibitors ea enzyme ho fokotsa ts'ebetso ea liprotheine tsa "pancreatic",
• li-antibacterial agents ho qoba lits'ebetso tsa ho ruruha tsa mokokotlo oa mpa, ho ruruha ha lehesa la semental bursa, nts'etsopele ea neancosis ea pancreatic le rotul cellulose ea sebaka se ka morao ho peritoneum,
• Li-blockers tsa H2 ho fokotsa tlhahiso ea hydrochloric acid,
• li-antacid tsa ho khelosa hydrochloric acid e ka mpeng,
• antispasmodics ea ho tsitsipana mesifa e boreleli e amanang le ho senyeha ha sphincter ka har'a pancreatic duct,
• lithethefatsi tsa anticholinergic ho thibela lits'ebetso tse sa tloaelehang ho ganglia le cortex ea litho tsa 'mele.

Ntle le moo, li-enzymatic agents li sebelisetsoa ho ntlafatsa ts'ebetso ea tšilo ea lijo le ho felisa ho senyeha ha dyspeptic.

Melemo e sebetsang

Ka letsatsi la pele la ho eketsa mofuta o sa foleng, ts'ebeliso ea liprotheine tsa thibelo ea pancreatitis e bohlokoa. Lithethefatsi tsena li tlosa sesosa sa ponahalo ea tsepamisang maikutlo le ho hasana ha libaka tsa necrotic.

Mithethefatsi e fumanoa ho pulmonary parenchyma le manyeme a likhomo.

Ka tlase ho litlhare tse sebetsang hantle haholo, ke hore na moriana o noang ngaka e ikemiselitseng ka kotloloho. Ha li fumanehe ka mokhoa oa matlapa, empa ka sebopeho sa ho tsepamisa mohopolo kapa lyophilisate bakeng sa infusion.

Phekolo ea pancreatitis le inhibitors e nang le tsamaiso ea methapo e etsoa feela ka boemo ba supine. Ho feta moo, mooki le ngaka ba lokela ho hlokomela boemo ba mokuli ka hloko. Lijo tsa bohlano 5, tse kopantsoeng le kalafo ea lithethefatsi, tse tla netefatsa ho fola ha mokuli ntle le mathata, le tsona li tlameha ho shejoa ka hloko.

Mokhoa oa ho phekola pancreatitis o tla bolelloa ke litsebi videong ena.