Vasonite: litaelo tsa tšebeliso, litekolo le theko

Vasonite e na le litlamorao tse latelang tsa lithethefatsi:

• ntlafatsa microcirculation madi libakeng tsa mafu a potoloha ka lebaka la ntlafalo rheological mali (mali),
• e sireletsa mabota a methapo ea mali liphellong tse mpe (angioprotectiveketso)
• e nchafatsa mesifa e boreleli ea marako a methapo ea mali (phello ea vasodilating),
• e thibela bokhoni ba mali ho thrombosis (Khahlano ketso)
• e ntlafatsa phepelo ea oksijene liseleng.

Sokolla foromo le sebopeho

Setlhare sena se fumaneha ka mokhoa oa matlapa a tsoang ho nako e telele, likhalase tsa filimi, 600 mg (likotoana tse 10 ka blister, lilakane tse 2 ka lebokoseng la karete.

Ntho e sebetsang ea Wasonite ke pentoxifylline, e le likarolo tse thusang, sethethefatsi se na le:

• Microcrystalline cellulose - 13.5 mg,
• Colloidal silicon dioxide - 3 mg,
• Magnesium stearate - 4,5 mg,
• Hypromellose 15000 cp - 104 mg,
• Crospovidone - 15 mg.

Khetla e kenyelletsa:

• Talc - 11.842 mg
• Hypromellose 5 cP - 3.286 mg,
• Macrogol 6000 - 3.943 mg,
• Tekanyetso ea titanium - 3.943 mg,
• Polyaconic acid (joalo ka 30% dispersion) - 0,986 mg.

Pharadodynamics

Pentoxifylline e bua ka lintho tse tsoang ho xanthine, tse lebisang ntlafatsong ea li-microcirc libakeng tse nang le phepelo e mpe ea mali. E kenya letsoho ntlafatsong ea methapo ea mali ea rheological ea mali (fluidity) ka lebaka la ts'usumetso ea ho fokola hoa lisele tse khubelu tsa mali tse bileng le liphetoho tsa methapo ea methapo. Pentoxifylline e boetse e etsa hore ho be le mongobo o kopaneng oa erythrocyte, e thibelang liplatelete le motsoako oa erythrocyte hape e fokotsa phallo ea mali e ntseng e eketseha.

Mochine oa ts'ebetso oa ntho e sebetsang ea Wasonite o hlahisoa ho thibelo ea phosphodiesterase le ho bokellana ha cyclic adenosine monophosphate (cAMP) liseleng tsa mali le lisele tse etsang mesifa e boreleli ea lijana. Pentoxifylline e fokotsa khatello ea methapo ea methapo ea methapo ea mali le mali e sebetsang, e lebisang ho fokotseheng hoa ponahalo ea mali le ntlafatso ea methapo ea eona ea methapo, hape e ntlafatsa sekhahla sa oksijene libakeng tseo ho fumanehang hore ho na le mathata a potoloho ea mali, maoto le matsoho ka mokhoa o fokolang. liphio. Ka liso tsa methapo ea methapo ea kutlo e tsamaeang le methapo ea kutlo, e tsamaeang le claudication ea nakoana, Wazonite e thusa ho fokotsa bohloko phomolong, e felise letsoalo la mesifa ea namane bosiu le ho eketsa sebaka sa ho tsamaea. Ka mathata a cerebrovascular, pentoxifylline e ntlafatsa matšoao. Ntho ena e tšoauoa ka phello e nyane ea myotropic vasodilating le ho atoloha ha likepe tsa coronary, hammoho le ho fokotseha hanyane hoa khatello ea methapo ea pelo.

Mofumahali

Kamora ho tsamaisoa ka molomo, pentoxifylline e batla e ananeloa ka botlalo ho tsoa ho tšilo ea lijo. E lokolloa ka sebopeho sa nako e telele, e netefatsang tokollo e tsoelang pele ea ntho le ho monya ha eona e ts'oanang 'meleng. Pentoxifylline e tšelisoa ka har'a sebete, e hlahisoa ke "ho fetela pele" ka sebopeho sa metabolite tse peli tse sebetsang tsa kemiso: 1-5-hydroxyhexyl-3,7-dimethylxanthine (metabolite I) le 1-3-carboxypropyl-3,7-dimethylxanthine (metabolite V). Boemo ba metabolites I le V ho plasma ea mali, ka tatellano, bo phahame makhetlo a 5 le 8 ho feta a pentoxifylline ka boeona. Ha tsamaiso ea molomo ea Wazonite e le ka har'a pompo ea litafole, litaba tse ka botlalo tsa pentoxifylline le metabolites ea eona e sebetsang ka har'a plasma ea mali li bonoa lihora tse 3-4 kamora ts'ebetso, mme phello ea kalafo e tsoela pele lihora tse ka bang 12. Excretion ea lithethefatsi e etsoa haholo ka liphio (hoo e ka bang 94%) ka sebopeho sa metabolites. E boetse e fetela lebeseng. Ka dysfunctions tse matla tsa sebete, excretion ea metabolites e fokotsa butle. Ka ts'ebetso ea ho se sebetse hantle ha sebete, ho eketsoa ha bioavailability le keketseho ea halofo ea bophelo.

Matšoao a ho sebelisoa

Ho latela litaelo, Vasonite e sebelisoa maemong a latelang:

• Likotsi tse mpe tse mpe tse mpe tsa "cypbrovascular" tsa ischemic,
• Dyscirculatory and atherosranceotic encephalopathy, lefu la Raynaud, paresthesia),
• Mathata a potoloha leihlo (ho hloleha ho potoloha ha mali le ho hlohlona ho choroid kapa retina ea leihlo),
• Ho senyeha ha potoloha ea potoloha khahlanong le semelo sa lefu la tsoekere, atherosmithotic le ts'oaetso (ho kenyelletsa ho nyefoloa ha nako le nako ho bakoang ke ho senyeha ha endarteritis, atherosclerosis, le lefu la tsoekere),
• Mathata a amanang le lefu la trophic a ileng a hlaha khahlano le semelo sa mathata a methapo ea methapo kapa ea methapo (trophic ulcers, frostbite, post-thrombophlebitis syndrome, gangrene),
• Ho se sebetse ha tsebe e bohareng ea methapo ea methapo, ho tsamaisana le tahlehelo ea litsebe.

Hape, Vasonitis e laeloa bakeng sa kalafo ea matšoao a kotsi ea koluoa ​​ea methapo ea methapo ea methapo e tsoang mothong (ho tsekela, ho tsepamisa mohopolo le ho hopola).

Contraindication

Contraindication mabapi le ts'ebeliso ea Wazonite ke:

• Ho tsoa mali haholo
• Ho hema hemorrhage
• Acal myocardial infarction,
• Hlooho ea hemorrhagic,
• Hypersensitivity ho likarolo tsa lithethefatsi le tse ling tse methylxanthine,
• Bokhachane le pelehi
• Lilemo tse ka tlase ho lilemo tse 18 (polokeho le katleho ea lithethefatsi tsa mokha ona oa lilemo ha li so theoe).

Ka hlokolosi, Vasonite e laeloa bakeng sa:

• Hlooho ea maikutlo
• Ho nyekeloa ke pelo ho sa feleng
• Pherekano ea morethetho oa pelo
• Atherosclerosis ea likepe tsa coronary le / kapa likhoerekhoere,
• Ho se sebetse ha liphio le sebete,
• Tloaelo ea ho tsoa mali
• Peptic ulcer ea mala le duodenum,
• Maemo ka mor'a ho buuoa haufinyane (ka lebaka la kotsi ea ho tsoa mali).

Litaelo tsa ho sebelisa vasonite: mokhoa le litekanyetso

Setlhare se lokela ho nooa ka molomo ka mor'a lijo, ntle le ho senya botšepehi ba pilisi le ho noa metsi a mangata.

Maemong a mangata, ho khothalletsoa ho nka Letlapa le le leng la 600 mg ea Wazonite hoseng le mantsiboea. Sekhahla se phahameng sa letsatsi le letsatsi ke 1200 mg.

Nako ea kalafo le kalafo ea litekanyetso li beoa ke ngaka ho latela setšoantšo sa kliniki ea lefu lena le phello e fumanoeng ea kalafo.

Phekolo ea bakuli ba nang le bothata ba ho phekola renal (CC ka tlase ho 30 ml / min), lethal dose la Wasonit 600 mg ha lea lokela ho sebelisoa.

Bakeng sa bakuli ba nang le ho senyeha ho matla ha hepatic, phokotso ea litekanyetso e lokela ho etsoa ka lebaka la mamello e le mong.

Phekolo ea bakuli ba nang le khatello e tlase ea mali, hammoho le bakuli ba kotsing ea ho fokotseha ha khatello ea mali (hemodynamically bohlokoa stenosis ea methapo ea methapo, e leng mokhoa o matla oa lefu la pelo), ho khothalletsoa ho qala ka litekanyetso tse nyane. Maemong a joalo, ho lumelloa keketseho ea butle-butle ea tekanyetso.

Litlamorao

Tšebeliso ea vasonite e ka baka litlamorao tse latelang:

• Ho tsoa ho ts'ebetso ea tšilo ea lijo: ho ruruha, ho nyekeloa le pelo le ho hlatsa, bohloko ba epigastric, molomo o omeletseng, takatso e fokotsehileng ea maikutlo, khatello ea maikutlo le khatello ea mpeng, atony ea mala, cholepatatic hepatitis, ho ata ha cholecystitis, ts'ebetso e eketsehileng ea alphaline phosphatase le enzymes ea sebete,
• Ho tsoa ho tsamaiso ea methapo e bohareng: ho opeloa ke hlooho le ho tsekela, likotsi tsa boroko, ho tšoenyeha, maloetse, maemo a nts'etsopele ea lefu la menateitis ea aseptic,
• Ho tsoa ho tsamaiso ea pelo: tachycardia, arrhythmia, ho theola khatello ea mali, tsoelo-pele ea angina pectoris, cardialgia,
• Ho tsoa ho sistopo ea hemopoietic le homeostasis: ka seoelo - thrombocytopenia, pancytopenia, anemia ea aplasiki, leukopenia, hypofibrinogenemia, ho tsoa mali (ho tsoa mala, lijana tsa mpa, mucous membrane le letlalo). Ts'ebetsong ea kalafo, ho hlokahala ho lekola khafetsa setšoantšo sa mali a pherekano,
• Ka lehlakoreng la letlalo le mafura a ikhethileng: ho fafatsa sefahleho le sefuba se kaholimo, masapo a mats'oafo a ile a phahama sefahleho, ho ruruha sefahleho, ho ruruha,
• Karolong ea litho tsa pono: ho senyeha hoa pono, scotoma,
• Litla-morao: hyperemia ea letlalo, angioedema ea Quincke, pruritus, urticaria, makala a anaphylactic.

Bongata

Ka overdose ea Vasonitis, ponahalo ea matšoao a kang bofokoli, ho otsela, ho tsekela, hyperemia ea letlalo, ho fokotseha ha khatello ea mali, tachycardia, areflexia, feberu (ho hlatsa) le ho akheha hoa khoneha. Ka nako e 'ngoe lithethefatsi tse ngata li tsamaisana le ho hlatsa mofuta oa "mabaka a kofi", a bonts'a ho tsoa mali ka mpeng, le ho ts'oaroa ke tonic-clonic.

E le kalafo, ho khothaletsoa sefuba ka mpeng, e lateloang ke ho kenella khabone e ts'oeroeng. Haeba ho hlatsa ho hlaha ka meroallo ea mali, phallo ea mpa e thibetsoe ka matla. Nakong e tlang, kalafo ea matšoao e laetsoe, e reretsoeng ho boloka khatello e tloaelehileng ea mali le ts'ebetso ea phefumoloho. Bakeng sa ho ts'oaroa, diazepam e khothalletsoa.

Litaelo tse khethehileng

Nakong ea kalafo, ho hlokahala ho laola khatello ea mali. Bakeng sa bakuli ba nang le khatello ea mali e tlase le e sa tsitsang, lethal dose le lokela ho fokotsoa.

Ha ho na le ts'oaetso e matla ea renal, kalafo e khothalletsoa tlasa tlhokomelo ea ngaka e haufi.

Haeba ho na le hemorrhage ka har'a leihlo la mahlo, ts'ebeliso ea Wazonite e lokela ho emisoa.

Ho beha leihlo tatellano ea hematocrit le hemoglobin hoa hlokahala kalafong ea bakuli ba sa tsoa etsoa opereishene.

Ka tšebeliso e tšoanang ea li-anticoagulants le vasonitis, matšoao a ts'ebetso ea mali a kopantsoeng le mali (ho kenyeletsoa INR) a lokela ho betoa leihlo.

Phekolo ea bakuli ba nang le lefu la tsoekere la mellitus ba noang lithethefatsi tsa hypoglycemic, ho hlokahala hore ho etsoe phetoho ea litekanyetso, kaha tsamaiso e le 'ngoe ea Wazonite ka tekanyetso e kholo e ka baka nts'etsopele ea hypoglycemia.

Phekolo ea bakuli ba tsofetseng e kanna ea hloka phokotso ea litekanyetso, ka lebaka la ho fokotseha ha tekanyo ea ho pepeseha le ho eketseha ha bioavailability.

Ts'ebetsong ea kalafo, ho khothalletsoa ho hana ho noa joala.

Ho tsuba ho ka thusa ho fokotsa phello ea kalafo ea Wazonite.

Ha ho khanna makoloi le ho sebelisa mekhoa e rarahaneng, tlhokomelo e lokela ho nkuoa, kaha tšebeliso ea lithethefatsi e ka baka tsitsipano.

Ho sebelisana le lithethefatsi

Pentoxifylline e khona ho ntlafatsa phello ea lithethefatsi tse amang tsamaiso ea mali ea mali (thrombolytics, anticoagulants e sa tobang le e tobileng), valproic acid, lithibela-mafu (ho kenyeletsa cephalosporins - cefotetan, cefoperazone, cefamandol). E eketsa katleho ea li-agents tsa hypoglycemic bakeng sa tsamaiso ea molomo, insulin le li-antihypertgency agents.

Cimetidine e eketsa boemo ba pentoxifylline ho plasma ea mali (mohlomong nts'etsopele ea litla-morao. Ts'ebeliso e kopaneng ea vasonite le li-xanthine tse ling e ka lebisa ho thabo ea letsoalo. Ho bakuli ba bang, ho kopana ha theophylline le pentoxifylline ho ka baka keketseho ea khatello ea theophylline, e tsamaeang le kotsi e eketsehileng ea litlamorao tse amanang le theophylline.

Li-Analogs tsa Wasonite ke: Pentilin, Pentilin Forte, Pentoxifylline-Acre, Trental 400.

Litlhahlobo mabapi le Wasonite

Tlhahlobo ea Wazonite har'a bakuli e ntle haholo. Ha u sebelisa lithethefatsi kalafong e rarahaneng ea maloetse a fapaneng a tsamaeang le mathata a potoloho ea potoloho, ho bonahala butle-butle maemo a bakuli a le teng. Leha ho le joalo, ho lokela ho hopoloa hore maloetse ohle a methapo a thata ho a phekola, a hlokang phekolo e rarahaneng ea nako e telele tlasa taolo ea setsebi.

Ho boetse ho na le litlhahlobo tse mpe tse mabapi le lithethefatsi tse amanang le tšebeliso e feteletseng le litlamorao tsa pentoxifylline. Ka hona, ho nka Vasonitis ho khothalletsoa feela kamora ho khethoa ha ngaka, e nahanang matšoao ohle le li-contraindication.

Phello ea pharmacological

Vasonite e ntlafatsa methapo ea mali le mali a rheological, e na le phello e matla. E na le pentoxifylline, motsoako oa xanthine, e le ntho e sebetsang. Mochine oa ts'ebetso o amahanngoa le thibelo ea phosphodiesterase le ho bokella ha cAMP liseleng tsa mesifa tse boreleli tsa methapo ea mali, linthong tse bopetsoeng ke mali, liseleng tse ling le litho tsa kahare.

Setlhare se thibela bongata ba liplatelete le lisele tse khubelu tsa mali, li eketsa ho eketseha ha tsona, li fokotsa boemo ba fibrinogen ka plasma ea mali le ho ntlafatsa li-fibrinolysis, tse fokotsang pono ea mali le ho ntlafatsa thepa ea tsona ea rheological. E ntlafatsa phepelo ea oksijene ea lisele libakeng tsa phallo e sa sebetseng hantle, haholo maotong, tsamaisong ea methapo, le, ho isa tekanyong e tlase, liphatseng. Hantle-ntle e hlapolla likepe tsa coronary.

Litlamorao

Litlhahlobo tsa Wasonite, le lingaka li hlokomela litla-morao tse joalo tse tsoang litsong tse fapaneng tsa 'mele, joalo ka:

1. Ho tloha lehlakoreng la tsamaiso ea methapo e bohareng: ho opeloa ke hlooho le ho tsekela, hammoho le ho khathatseha boroko, ho tšoenyeha, leha liketsahalo tse joalo li etsahala seoelo,
2. Ho tsoa ho tšilo ea lijo: ho felloa ke takatso ea lijo, lets'ollo, ho nyekeloa le pelo le ho hlatsa, bohloko ba lehare la kahare, maikutlo a ho tlala ka mpeng.
3. Ho tsoa ho li-system tsa ho kopanya ha hemopoietic le mali: ho tsoa mali ka har'a li-membrane tsa mucous, letlalo, pampitšana ea mala, hammoho le anemia ea aplasiki, thrombocytopenia. Ha u ntse u nka Wasonite, ho hlahlojoa boemo ba mali hoa hlokahala.
4. Ho tsoa ho ts'ebetso ea pelo: tachycardia, ho sesa sefahleho, ho theola khatello ea mali, angina pectoris, ts'oenyeho ea morethetho oa pelo - matšoao ana a na le litekanyetso tse phahameng tsa moriana,
5. Boitšoaro bo kulisang: lekhopho la letlalo, ho hlohlona, ​​urticaria, ho ts'oaroa hoa anaphylactic (ka seoelo haholo), edema ea Quincke.

Vasonit ea lithethefatsi - litla-morao

Vasonite e na le litlamorao tse ngata tse tsoang ho litho tse ling le litsamaiso tse ling.

Ka tsamaiso ea methapo e bohareng - Sena ke ho tsepamisa mohopolo haholo, ho kenyelletsa ho akheha, ho opeloa ke hlooho, ho otsela kapa ho hloka boroko, ho ikemisetsa ho khothala, linyeoe tsa ntšetso-pele meningitis. Ho ikoetlisa ho ka baka tšitiso likoloing tsa ho khanna, kahoo nakong ea kalafo u se ke oa khanna.

Ka tsamaiso ea potoloho - ho otla ha pelo, pherekano ea morethetho oa pelo, bohloko ba pelo (ho kenyeletsoa le ha u ts'oaroa angina pectoris), ho fokotseha ha khatello ea mali (ka linako tse ling e bohale ebile e bohlokoa).

Ho tloha ntlheng ea pono - Tlolo ea molao oa pono, tahlehelo ea masimo a pono.

Ka gastrointestinal pampitsana - Ho fokotse takatso ea lijo, molomo o omileng, ho nyekeloa ke pelo, ho hlatsa, lets'ollo, ho fapanyetsana le ho sokelaho teba le ho utloa bohloko ka mpeng.

Ka sebete le pampiri ea biliary- bohloko bo ka har'a hypochondrium e nepahetseng, ho se sebetse ha nakoana ha sebete, ho mpefala ha ts'oaetso ea ts'ebetso ea methapo ea methapo le lesapo la nyooko (le sa foleng) cholangitis le cholecystitis).

Ho tsoa tsamaisong ea mali - Ho tsoa mali ho eketsehileng, ho tsoa mali ho tsoa litho tse ka hare, marenene, nosebleeds, ho fokotseha hoa mali a likarolo tsohle tsa seluloana palo ea liplatelete le lisele tse tšoeu tsa mali. Ntshetsopele le eona ea khonahala. phokolo ea mali.

Ka lehlakoreng la letlalo le lihlahisoa tsa lona- ho thunyetsa ha mali ho isa halofong e kaholimo ea 'mele le sefahlehong, ho ruruha, ho fokotseha ha lipolanete tsa lipekere.

Bongaka bo ka baka allergy, e iponahatsang ka sebopeho urticaria, Quincke edemalekhopho la letlalo le ho makala. Mohlomong ntshetsopele ea karabelo e matla ea allergic ka mokhoa oa anaphylactic makala.

Vazonit - litaelo tsa tšebeliso

Palesa ea lipalesa ho kgothaletswa ho nka piritsi ea 600 mg habeli ka letsatsi ka mor'a lijo, ntle le ho hlafuna le ho noa ka metsi.
Bakeng sa bakuli ka bomong, litekanyetso tsa moriana, nako e tšoanang ea ho nka litafole e khethoa ka kotloloho ke ngaka.

Kahoo, thuto ea ts'ebeliso ea Wazonite bakeng sa kalafo ea bakuli ba nang le ts'oaetso ea sebete le liphio, khatello e tlase ea mali le botsofaling li khothaletsa ho fokotsa tekanyetso e tloaelehileng.

Tšebelisano ea Wazonite le lithethefatsi tse ling

Lithethefatsi li sebelisana le meriana e mengata, e ntlafatsa ketso:

• lithethefatsi tse hatellang ketso ea mokhoa oa ho kopanya mali - ka kotloloho le ka kotloloho anticoagulants le ba bang
• lithibela-mafu tse tsoang sehlopheng cephalosporins(mohlala. ceftriaxone),
• valproic asiti - sethethefatsi se nang le phello ea anticonvulsant,
• meriana e fokotsang khatello ea mali,
• lithethefatsi bakeng sa kalafo ea lefu la tsoekere.

Ha e nkuoa le theophylline overdose ea morao e ka hlaha.

Ha e nkuoa le cimetidine ho na le kotsi ea ho overdose ea Wasonite.

Li-analog tsa Wasonite

Li-analog ke lithethefatsi tsa lihlopha tse fapaneng tsa meriana tse sebelisetsoang ho phekola mafu a tšoanang. Analogue ea Wasonite ke Xanthinol Nicotinate (Kananelo, Thiokol) - lithethefatsi tse nang le litlamorao tse tšoanang, empa ntho e sebetsang e fapane. E ntlafatsa phallo ea mali a pharalletseng (ho kenyeletsa le phallo ea mali sebakeng sa bokong le sebopeho sa pono), e phahamisa phepelo le khokahano ea oksijene ke lisele tsa boko, e fokotsa pokello ea liplatelete.

Fomu ea tokollo, sebopeho sa moriana

Lipalesa tsa lipalesa li entsoe ka mofuta o le mong. Foromo ea meriana - litafole tse sebetsang nako e telele. Dragee ka 'ngoe e koahetsoe ka filimi e tšesaane, e na le sebopeho sa oval e tsoang mahlakoreng ka bobeli. Karolo e ka sehloohong e sebetsang ke pentoxifylline.

Letlapa ka leng le na le lithethefatsi tse 600 mg. Karolo ea khetla e kenyelletsa macrogol 6000, polyaconic acid, titanium dioxide, talc. Matlapa a tletse ka blister ea likotoana tse 10 ngoe le e ngoe. Lipalesa tsa lipalesa li kenngoa ka lebokoseng la karete e nang le karete hammoho le se hlalosoang. Pakete e le 'ngoe e kanna ea ba le lilakane tse 1-2.

Mochine oa ts'ebetso, pharmacokinetics

Vasonite e etselitsoe ho etsa hore mali a tsamaee ka bongata. E na le "vasodilating, angioprotective effect". Pentoxifylline, e 'ngoe ea likhakanyo tsa xanthine, e sebetsa e le karolo ea mantlha. Sesebelisoa se thibela phosphodiesterase, e khothalletsa ho bokella cyclic adenosine monophosphates.

Moriana o thibela ho kopana ha lisele tse khubelu tsa mali, liplatelete, li eketsa ho bonoa ha tsona, li fokotsa maemo a fibrinogen. Pentoxifylline e boetse e na le phello e holang likepe tsa coronary, e khutlisetsa lipalangoang tsa oksijene libakeng tse nang le ho potoloha ho potoloha ha mali. Tšusumetso e ntle ho tsamaiso ea methapo e bohareng, ho potoloha ha kokoana-hloko, ho isa tekanyong e fokolang liphihlelong.

Pentoxifylline e boetse e sebetsa hantle ho haptjoeng ke likepe tse potolohang, e tlosa mesifa ea bosiu le ho fokotsa bohloko ba bohloko. Litaelo tsa moriana o boetse li hlalosa phello e bonolo ea myotropic, vasodilating.

Tšusumetso ea kalafo e ka nka lihora tse 12.

Ka tsamaiso ea molomo ea Wazonite, ntho e sebetsang e batla e le 100% e tsoang mohloling oa mpa. Moemeli o na le tšusumetso ea nako e telele, ha karolo e sebetsang e lokolloa ka mehla, ebe e kenella ka ho lekana. Palo e phahameng ea lithethefatsi maling kamora ho tsamaisoa e lokiselitsoe kamora lihora tse 3-4. Setlhare se tlosoa hoo e batlang e le ka botlalo ke liphio. Ho pepesitsoe ka lebese la matsoele.

Ho ngatafatsa ho amoheloa, dosing

Ho latela sefuba, Vasonite e nkuoa ka molomo ka mor'a lijo, ntle le ho e senya, e hlatsuoa ka sekhahla se hlokahalang sa metsi. Tekanyetso e tloaelehileng ke Letlapa le 1 600 mg hoseng le hora ea mantsiboea. Tekanyo e phahameng ka ho fetisisa ka letsatsi ke 1200 mg. Nako ea phekolo e fanoa ke ngaka ho latela ho teba ha lefu lena, setšoantšo sa kliniki ea lefu lena.

Phekolo ho bakuli ba nang le ts'ebetso e matla ea sebete le liphio, phokotso ea litekanyetso tse tloaelehileng e ea hlokahala ho latela tumello ea moriana. Haeba tumello ea creatinine e ka tlase ho 30 ml / min, tekanyetso e lumelletsoeng ka botlalo ea ho kokota e ke ke ea feta 600 mg. Molemong oa phekolo ea bakuli ba nang le khatello e tlase ea mali, nete ea kalafo e qala ka litekanyetso tse nyane (150-300 mg), butle-butle e ntse e eketseha, ha ho ntse ho hlahlojoa matšoao.

Lithethefatsi tse tšoanang

Haeba ho sa khonehe ho sebelisa Wazonit, ho ka khonahala ho fana ka litlhare tse ling tse tšoanang ka ts'ebetsong. Li-analogues tse ling li theko e tlase ho feta sethethefatsi se hlalositsoeng, ka hona bakuli ba khetha ho li khetha.

Lithethefatsi tse thathamisitsoeng li ka hlahisoa ka tsela ea tharollo ea ente. Maemong a matla a kalafo, ho molemo ho khetha liente, hobane ente ea lithethefatsi e amoheloa e sebetsa hantle haholo.

Tekanyetso le tsamaiso

Ho tsoa litaelo tsa Wazonit, o ka fumana hore moriana o lokela ho nooa kamora lijo, ntle le ho hlafuna le ho noa metsi a mangata a nooang. Hangata, ngaka e khetha hore na lethal dose le hore na o tla fumana kalafo hakae ho latela pale ea mofuta oa lefu lena. Empa, ha e le hantle, litekanyetso tse tloaelehileng ke Letlhare le le leng habeli ka letsatsi.

Tekanyo e phahameng ke 1,2 g ka letsatsi.

Litaelo tsa ho sebelisa Vazonit 600 mg, litekanyetso

Matlapa a lokela ho nooa ka molomo, ntle le ho hlafuna le ho noa metsi a mangata, haholo-holo ka mor'a lijo.

Litekanyetso tse tloaelehileng, ho latela litaelo tsa ts'ebeliso ea Vazonit - 1 letlapa la Vazonit 600 mg makhetlo a 2 ka letsatsi. Sekhahla se phahameng sa letsatsi le letsatsi ke 1200 mg (matlapa a 2).

Nako ea kalafo le kalafo ea litekanyetso li beoa ke ngaka ho latela setšoantšo sa kliniki ea lefu lena le phello e fumanoeng ea kalafo.

Tlhahisoleseling ea Bohlokoa

Bakeng sa bakuli ba nang le bothata ba ho sebetsa ka thata ba sebete, ho fokotsoa ka tekanyetso hoa hlokahala ho nahanela mamello e le 'ngoe.

Phekolo ea bakuli ba nang le khatello e tlase ea mali, hammoho le bakuli ba kotsing ea ho fokotseha ha khatello ea mali (hemodynamically bohlokoa stenosis ea methapo ea methapo, e leng mokhoa o matla oa lefu la pelo), ho khothalletsoa ho qala ka litekanyetso tse nyane. Maemong a joalo, ho lumelloa keketseho ea butle-butle ea tekanyetso.

Bakeng sa bakuli ba nang le bothata ba ho phekola renal (CC ka tlase ho 30 ml / min), lethal dose le letsatsi le fokotsoa ho 600 mg.

Synonyms of Wasonite

Ho boetse ho na le li-synonyms tse ngata tsa Wazonite, ke hore, lithethefatsi tseo motsoako oa tsona o sebetsang ke pentoxifylline. Ho joalo Flexital, AgapurinTrental, Latren, Pentoxifylline le ba bang

Li-analog tsa vasonite, theko ea litlhare

Haeba ho hlokahala, o ka kenya Vasonite sebakeng sa analogue ea ntho e sebetsang - tsena ke lithethefatsi:

Ha u khetha li-analogues, ho bohlokoa ho utloisisa hore litaelo tsa tšebeliso ea Vazonit 600 mg, theko le litekolo tsa lithethefatsi tse nang le litlamorao tse tšoanang ha li sebetse. Ho bohlokoa ho fumana tlhahlobo ea ngaka le ho se etse phetoho e ikemetseng ea lithethefatsi.

Theko ea meriana ea litlama ea Russia: Vazonit 600 mg e khutlisa matlapa a 20 - ho tloha ho li-ruble tse 393 ho isa ho tse 472, ho latela litlatsetso tsa 582.

Bophelo ba Shelf ke lilemo tse 5. Boloka ka mocheso o sa feteng 25 ° C sebakeng se ommeng le se lefifi moo bana ba ka se fihlelang. Maemo a ho ajoa ho tloha litlolong tsa litlhare ke ngaka.

Litekolo li reng?

Bongata ba litlhahlobo li ntle, ka ho hlahisoa ha matlapa a Vazonit kalafong e rarahaneng ea maloetse a fapaneng a nang le mathata a potoloho ea mali, boemo ba bakuli bo ntse bo ntlafala butle-butle. Empa maloetse ohle a methapo a thata ho a phekola mme a hloka kalafo e rarahaneng ea nako e telele tlasa taolo ea ngaka.

Litlhahlobo tse mpe mabapi le Wazonit 600 mg li amahanngoa le litlamorao le tšebeliso e feteletseng ea lithethefatsi. Ke ka lebaka leo e lokelang ho laeloa ke ngaka, ho nka matšoao ohle le li-contraindication.

Maikutlo a 2 a "Wazonite 600 mg"

Re rekile lipilisi tsena bakeng sa bo-mme bekeng e fetileng. O ile a otloa ke setorouku se holofetseng ka letsoho. Ba khutletse sepetlele ba nkile lengolo la ngaka ea meriana ena, re e emetse hore e sebetse. Hajoale, bonyane liphetho tse ling ha li bonoe.

Pentoxifylline e theko e tlase ho feta li-analogu tse nang le se ts'oanang empa li na le lebitso le fapaneng