Fenofibrate e sebelisoa joang?

Fenofibrate ke lithethefatsi tse fokotsang lipid tse sebelisetsoang ho phekola hypercholesterolemia le hyperlipidemia e tsoakiloeng. Litlamorao li ipapisitse le ts'ebetso ea li-receptor tsa PPARcy. Hangata moriana o nooa hangata ka letsatsi. Litlamorao tse atileng haholo ke ho opeloa ke hlooho le ho nyekeloa. Fenofibrate e ka etsa hore letlalo le ele hloko khanya ea letsatsi.

Sebopeho le mofuta oa tokollo

Fenofibrate e fumaneha ka mokhoa oa phofo e tšoeu ea kristale, e sebetsang hantle hoo e seng metsi. Phetoho e hlahisoa ka har'a 'mele hore e sebetse ka matla fenofibric acid.

Hajoale (2018), fenofibrate ea micronized e sebelisoa haholo.

E khahla! Setlhare sena se hlahisitsoe ke khamphani ea litlama e bitsoang Fournier Pharma. United States, e fetohile lithethefatsi tse fanang ka phaello e phahameng ka ho fetisisa ea ho rekisa lipid.

Melemo ea pharmacological

Li-PPAR ke li-receptors tsa nyutlelie tse hlahisoang ke li-ligand tsa tlhaho kapa tsa maiketsetso, hape li eketsa kapa li thibela polelo ea mefuta e itseng. Ho na le li-receptor tsa PPA alpha, beta le gamma. Hoo e batlang e le mefuta eohle ea fiber e tlama ka ho khetheha li-alpha receptors.

Litlamorao tse ka sehloohong tsa lithethefatsi:

• E thibela tlhahiso ea apolipoprotein C3 (APOC3), eo ka nako e thibang lipoprotein lipase e ikarabellang bakeng sa hydrolysis ea intravascular triglycerides (TG). PPAR-alpha e eketsa tšebetso ea lipoprotein lipase, e fokotsang khoholeho ea li-triglycerides maling
• E ntlafatsa tlhahiso ea APOA1, APOA2 ka hona HDL
• Nakong ea liteko tsa tleliniki tse entsoeng ka fenofibrate, cholesterol e felletseng ea mali e fokotsehile lipakeng tsa 20 le 25%, mme HDL e eketsehile ho tloha ho 10 ho isa ho 30%
• Fokotsa polelo ea endothelin-1, e leng vasoconstrictor e matla. Hape, ka mochine ona, li-fibrate li fokotsa ho hlahisa li-cytokines, haholo-holo IL-1 le IL-6, ka hona, li na le phello e matla ea khahlanong le ho ruruha. Hape hoa tsebahala hore ho sebelisa PPAR-alpha, li-fibrate tse ling li ka fokotsa polelo ea fibrinogen, ka hona ba khona ho ba le phello ea antithrombotic
• E eketsa secretion ea cholesterol ka bile, e ka tlatsetsang lithogeneisis.

Khokahano e kholo ea plasma (Cmax) e fihlella lihora tse 2-4 kamora ho tsamaisoa ka molomo. Bioavailability e fokotseha haholo haeba moriana o nooa le lijo. Kamora ho tsamaisoa ka molomo, fenofibrate e potlakisa hydrolyzed ke litekanyetso ho metabolite e sebetsang - fenofibric acid. Fenofibric acid e amana hantle le plasma albin (ho feta 98%). Ha ho fenofibrate e sa fetoheng e fumanoeng plasma. Lithethefatsi ha se karolo e ka tlase ea cytochrome P450. Moriana ha o amehe ho metabolism ea hepatic microsomal.

Setlhare se tlosoa mmeleng haholo-holo ka moroto. Hoo e ka bang sehlahisoa sohle se felisoa ka beke. Fenofibrate ka kakaretso e tlosoa ka mokhoa oa fenofibric acid le tsoekere ea eona ea glucuroconjugate. Ho bakuli ba tsofetseng, ho hlakisoa ha fenofibric acid ha ho fetohe. Lithuto tsa Pharmacokinetic kamora tekanyetso e le 'ngoe le kalafo e tsoelang pele e bontša ho haella ha ho bokellana. Fenofibric acid ha e felisoe ke ts'ebetso ea dialysis. Bophelo ba halofo ke lihora tse 20.

Matšoao a ho sebelisoa

Litšenyehelo tse tloaelehileng tsa Fenofibrate ke li-ruble tse 800 tsa Russia.

Fenofibrate e sebelisoa ho kenyelletsa lijo kapa litlhare tse ling ntle le ho ikoetlisa, ho theola boima ba 'mele kalafong ea kalafo ea mofuta II, III, IV le V hyperlipidemia. Fenofibrate e lokela ho nkuoa feela e le sethethefatsi sa mola oa bobeli. Moriana o ka sebelisoa feela ha ho e-na le mokokotlo o mongata oa lipids maling o bonoa. E lokela ho sebelisoa e le mokhoa o mong haeba lintho tse ling tse sebetsang tse tsoang sehlopheng sa li-statin li sa sebetse kapa li sa lumellane.

Lithutong, kalafo ea fenofibrate e theole maqhubu a ho hlaseloa ke pelo ho lefu la pelo. Leha ho le joalo, ha ho e-so fumanoe hore lithethefatsi li na le tšusumetso e ntle ho nts'etsopele ea mafu a pelo le methapo.

Litaelo tsa ho sebelisoa

Ho latela litaelo, fenofibrate hangata e nkuoa hang ka letsatsi. Ho ja ka nako e tšoanang ho fokotsa tšebeliso ea lithethefatsi ka nako e tšoanang. Ho khothalletsoa ho noa letlapa le nkiloeng ka metsi.

Ts'ebeliso nakong ea bokhachane le nakong ea matsoele ha e khothalletsoe, hobane, ho latela litaelo tsa tšebeliso, moriana o na le phello ea teratogenic.

Contraindication, litla-morao, ts'ebeliso e ngata ea lithethefatsi

Fenofibrate e hanyetsanoa haeba ho na le hypersensitivity, nephropathy, ho hloleha ha sebete, ho phehella ho sa sebetse hantle ha hepatic, mafu a gallbladder, photogergic e fetileng kapa mokhoa oa ho nka lifoto. Tabeng ea letlaloensensitivity (mokhoa oa ho nka lifoto) ka 'mala, ho thunya, ho thunya le ho hlohlona, ​​motsoako o sebetsang o lokela ho emisoa.

Ho khothalletsoa hore o tsebise ngaka ea hau hang ka bohloko, bofokoli le mesifa ea mokokotlo. Basali ba nang le bokhoni ba ho ba le bana ba lokela ho ela hloko thibelo ea bokhachane e sebetsang nakong ea kalafo.

Fenofibrate e baka ho teneha ka mpeng le ka mpeng, e eketsa li-enzyme tsa sebete, khatello ea Homocysteine. E boetse e baka bohloko ba mesifa, ho ruruha ho honyenyane, gallstones, le ho phahamisa litekanyetso tsa creatine kinase. Boithuto ba tsa bongaka bo senotse hore moriana o ka baka pherekano e kholo ea maikutlo ka ts'ebeliso ea nako e telele.

Ho sebelisana le lithethefatsi hoa khoneha ka li-anticoagulants tsa molomo, cyclosporine, lintho tsa hepatotoxic le li-blocker tsa monoamine oxidase. Fenofibrate ke inhibitor ea li-isoforms tse ling tsa cytochrome P450.

Litšoantšo tsa sehlooho tsa Fenofibrate: Fenofibrate Canon le Tricor.

Fenofibrat Canon

Moqapi - Canonfarm Production CJSC (Russia)

Theko - ho tloha ho li-ruble tse 820

Tlhaloso - Matlapa a koahetsoeng ka filimi a sebelisetsoang ho phekola lipids tse phahameng tsa mali

Melemo - E fokotsa phallo ea lipoprotein tse tlaase le tse tlase haholo, e eketsa HDL mme e na le phello ea antithrombotic ho litekanyetso tsa kalafo

Cons - e baka mokhathala, ho opeloa ke hlooho, khatello ea maikutlo, mpa, hepatitis le ho hloleha ha renal ho hlobaetsang

Moqapi - Recipharm Fontaine (France)

Theko - ho tloha ho li-ruble tse 1200

Tlhaloso - matlapa a koahetsoeng ka filimi a nang le fenofibrate ea micronized, e sebelisetsoang ho phekola maemo a phahameng a cholesterol le triglycerides maling.

Melemo - e fokotsa khatello ea kelello ea LDL, VLDL, fibrinogen le ho eketsa HDL. Litaba tsa matšoao a ho ruruha le li-uric acid tse maling le tsona lia fokotseha.

Cons - e baka dyspepsia, ho eketsa li-enzyme tsa sebete, jaundice, gallstones, rhabdomyolysis, erectile dysfunction le cephalgia e matla.

Lokolla liforomo le sebopeho

Setlhare se entsoe ka mokhoa oa matlapa a kopaneng ka membrane. Setsi ka seng sa lithethefatsi se na le fenofibrate e ka bang 145, 160 kapa 180 mg ka mokhoa oa nanoparticles. Ha ho sebelisoa likarolo tse ling:

• tsoekere ea lebese
• phospholle cellulose,
• crospovidone
• hypromellose,
• dehydrogenated silicon diokolate
• sucrose
• lauryl sulfate le sodium e tšehetsang,
• magnesium stearate.

Setlhare se entsoe ka mokhoa oa matlapa a kopaneng ka membrane.

Khetla e kantle e na le talc, xanthan gum, titanium dioxide, joala ba polyvinyl le soya lecithin. Matlapa a maputsoa a na le sebopeho se phahameng se nang le mongolo ka mahlakoreng a mabeli a foromo ea litekanyetso, a bonts'a lengolo la pele la ntho le moriana o sebetsang.

Mokhoa oa ketso

Matlapa a Fenofibrate ke a sehlopha sa baemeli ba hypoglycemic mme ke derivative ea fibroic acid. Ntho ena e na le matla a ho ama boemo ba lipids 'meleng.

Thepa ea pharmacological e bakiloe ke ts'ebetso ea RAPP-alpha (receptor e entsoeng ke proliferator ea peroxisis). Ka lebaka la phello e tsosang, ts'ebetso ea metabolic ea ho putlama ha mafura le lits'oants'o tsa methapo ea methapo ea methapo ea methapo ea methapo ea methapo (LDL) ea matlafatsoa. Ho thehoa ha apoproteins AI le AH hoa ntlafatsoa, ​​ka lebaka leo boemo ba lipoproteins tse phahameng (HDL) bo eketsoang ka 10-30% mme lipoprotein lipase e sebetsoa.

Ka lebaka la ho khutlisoa ha metabolism ea mafura bakeng sa ts'ebetso ea tlolo ea sebopeho sa VLDL, fenofibrate compact e eketsa tlhahiso ea LDL, e fokotsa palo ea likaroloana tse ngata tsa lipoprotein tse fokolang tse nang le boholo bo nyane.

Maemo a LDL a eketseha ho bakuli ba kotsing ea ho ba le lefu la pelo.

Setlhare se thusa ho fokotsa cholesterol ka 20-25% le triglycerides ka 40-55%. Boteng ba hypercholesterolemia, boemo ba cholesterol e amanang le LDL bo fokotseha ho fihla ho 35%, ha hyperuricemia le atherosulinosis li fokotseha ka bongata ba uric acid maling ka 25%.

Mofumahali

Ha motsoako oa fenofibrate o nkuoa ka molomo, o kenella karolong e haufi ea mpa ea hae e nyane o sebelisa microvilli, moo e kenang methapong ea mali. Ha e kena ka mpeng, ntho e sebetsang e sebetsa hang-hang e nka qeto ea ho fenofibroic acid ka hydrolysis e nang le li-esterase. Sehlahisoa se bolileng se fihla maemong a mangata a plasma nakong ea lihora tse 2,4. Ho ja ka sekhahla sa ho monya le bioavailability ha ho ame ka lebaka la nanoparticles.

Ha e kena ka mpeng, ntho e sebetsang e sebetsa hang-hang e nka qeto ea ho fenofibroic acid ka hydrolysis e nang le li-esterase.

Motseng oa mali, komporo e sebetsang e hokahana le plasma albin ka 99%. Setlhare ha se nke karolo ho microsomal metabolism. Bophelo ba halofo e fihla lihora tse 20. Nakong ea liteko tsa tleliniki, ho ne ho se na linyeoe tsa ho qhekella ka bobeli kapa ka taolo ea nako e telele ea lithethefatsi. Hemodialysis ha e na thuso. Moriana o tšeloa ka mokhoa oa fenofibroic acid ka botlalo ka matsatsi a 6 ka har'a ts'ebetso ea urine.

Contraindication

Sesebelisoa ha se fanoe ka lebaka la litlolo tse thata:

• hypersensitivity ho fenofibrate le lintho tse ling tsa sebopeho sa lithethefatsi,
• lefu la sebete
• khatello e matla ea renal,
• lefutso le lefu la tsoalo, bofokoli ba lactase le sucrose, tsoekere e kulang le ho kenngoa ha galactose,
• nalane ea maloetse a mesifa ea lefutso,
• sensitivity to light ha o tšoaroa ke Ketoprofen kapa fiber tse ling,
• ts'ebetso ea methapo ea methapo ka gallbladder.

Setlhare ha se fuoe bakeng sa lefutso la lefutso.
Moriana ha o fuoe lefu la sebete.
Setlhare ha se fuoe lefutso la lefutso.
Moriana ha o fuoe ho fufuleloa haholo ha renal.
Moriana ha o fuoe mafu a lefutso la lefutso historing.
Setlhare ha se laeloe lits'ebetso tsa pathological ka gallbladder.

Batho ba nang le karabelo ea anaphylactoid ho peanse le botoro ea peanut ha baa lokela ho nka moriana.

Sehlopha sa meriana, INN, boholo

Fenofibrate ke ea sehlopha se ikhethang - lithethefatsi tse fokotsang lipid tse entsoeng motheong oa fibroic acid. Lithethefatsi tse joalo li khona ho fokotsa ka mokhoa o hlakileng "cholesterol" e mpe maling le ho fokotsa boemo ba triglycerides.

Setlhare sena se sebelisetsoa ho fokotsa khatello ea lipids, e leng ho bokellana ho fetelletseng hoa bophelo ba motho. Hangata ho laeloa bakuli ba nang le lefu la tsoekere mellitus, ba nang le methapo ea pelo le methapo ea mali (mohlala, pelo ischemia, atherosclerosis) ho lokisa boemo ba lipids.

INN ke Fenofibrate, hobane ke karolo ena e fumanehang ka har'a moriana e khethang mohato oa ketso ea ona holim'a 'mele.

Foromo ea tokollo, litjeho ho la Russia

Moriana o ntšoa ka mokhoa oa matlapa a nang le 'mala o mosoeu, sebopeho se potolohileng le mohala o arohanang. Letlapa le leng le le leng le na le karolo ea 145 mg ea motsoako o sebetsang. Li tletse ka lithupa tsa polasetiki bakeng sa likotoana tse 7, 10 kapa 15. Ka kakaretso, ka lebokoseng la lik'hateboto ho na le matlapa a 10 ho isa ho a 100.

Theko e ipapisitse le palo ea matlapa a sephutheloaneng, hammoho le sebakeng seo ho rekisoang moriana teng. Litefiso tse tloaelehileng tsa sephutheloana sa matlapa a 30 a 145 mg libakeng tsa meriana ea litoropo tse kholo tsa Russia li hlahisoa ka har'a tafole.

Theko e theko e phahameng ka ho fetisisa e fanoa ke li-pharmacin tsa inthanete. Ha u le moo u ka odara ho tsamaisoa ka potlako ntlong ea hau.

Lisebelisoa tse kopaneng

Sesebelisoa se ka sehloohong sa lithethefatsi ke fenofibrate. E bitsoa "li-fibroic acid derivatives" (fibrate). Letlapa le leng le na le 145 mg ea ntho ena. Ho feta moo, sebopeho sa moriana o kenyelletsa likarolo tse joalo - selulose, magnesium stearate, povidone, mannitol, starch, silicon dioxide. Ba na le ts'ebetso e thusang.

Thepa ea pharmacological

Fenofibrate e khona ho kenya tšebetsong likarolo tse khethehileng tsa alpha receptors (RAPP). Sena se lebisa ho lipolysis tse eketsehileng le ho tlosoa ha lipoprotein tse kotsi tse tsoang maling, tse ka bokellanang le ho beoa maboteng a methapo ea mali, ho hlahisa litlamorao tse mpe. Tabeng ena, ho latela melemo e latelang:

• fokotseha ha triglycerides le cholesterol e mpe,
• ho fokotseha ha palo ea uric acid (phello ea uricosuric),

normalization of platelet aggregation (thibelo ea thrombosis),

Kamora ho tsamaisoa ka molomo, moriana o kenella ka botlalo ka seterateng sa ka mpeng ka mor'a lihora tse 4. Haeba e nkuoa ka mokhoa o hlophisehileng, joale khatello ea mali maling a ntho e sebetsang e lula e le teng kamehla. Fenofibrate e kopanya hoo e ka bang ka botlalo ho liprotheine tsa mali.

Ts'ebetsong ea ts'ebetso ea eona ea fenofibroic acid e thehoa. Ho microsomal metabolism ha e nke karolo. Ho etsa lintho hantle ho hlaha ka liphio. Half-life e bonoa lihora tse 20 kamora tsamaiso. Ho tla nka matsatsi a ka bang 6 ho tlosa lihlahisoa tsa fenoforbit metabolites ka botlalo.

Matšoao le mefokolo

Moriana o laetsoe ho fokotsa boemo ba triglycerides le cholesterol e tlase e nang le methapo e joalo:

Dyslipidemia e tsoakiloeng. Hangata ho hlaha ka mafu a joalo:

• lefu la tsoekere
• ischemia
• lits'ebetso tsa atherosclerotic methapong ea methapo ea methapo kapa ea methapo,
• aborinal artery aneurysm,
• mathata a mang a coronary. Hangata moriana o sebelisoa hammoho le li-statins ho fokotsa li-triglycerides le ho eketsa HDL (cholesterol e thusang).

Nako le kalafo ea kalafo e khethoa ke ngaka e eang. Pele o fana ka moriana, o lokela ho etsa bonnete ba hore mokuli ha a na litlolo tse joalo:

• ho se mamellane ha likarolo tsa sehlahisoa sena,
• ho hloleha ho matla ha renal,
• hypersensitivity ho fibrate le Ketoprofen,
• gallbladder
• pancreatitis e sa foleng kapa e hlobaetsang (ntle le e bakiloeng ke hypertriglyceridemia),
• bana le bacha,
• nako GW,
• boimana
• ts'ebetso ea ho se sebetse hantle ha sebete (cirrhosis).

Setlhare ha se so etse liteko ho bana ba banyenyane, basali ba bakhachane le bo-'mè ba anyesang. Ka hona, kotsi e ka bang teng bakeng sa baahi ba joalo ha e tsejoe. Kaha fenofibrate e khona ho kenella ka har'a placenta le ka lebese la matsoele, ha ho kgothaletswe ho e sebelisa e le hore e se ke ea utloisa ngoana bohloko.

Ka tlhokomeliso e fetelletseng le tlas'a taolo ea ngaka, sethethefatsi se sebelisetsoa hypothyroidism, pathologies ea renal, hammoho le kalafo ea bakuli ba tsofetseng le batho ba sebelisang joala hampe.

Thupelo ea ts'ebeliso

Ho bohlokoa ho nka fenofibrate hantle. Sena se tla thusa litaelo tsa tšebeliso, tse khothaletsang:

1. Tšela matlapa kahare ntle le ho hlafuna ka metsi.
2. Moriana o nooa hang ka letsatsi, o kopanya tšebeliso ea oona le lijo tse ngata (ka hona o ananeloa hamolemo).
3. Tekanyetso ea lithethefatsi ea li-pathologies tse fapaneng ke 145 mg ka letsatsi. Bakuli ba tsofetseng ha ba hloke phetoho ea litekanyetso.

Fenofibrate e lokela ho nkoa nako e telele. Tabeng ena, lijo tse khethehileng tsa hypocholesterol li lokela ho bonoa.

Kamora nako e itseng (likhoeli tse ka bang 3 kamora ho qala kalafo), mali a mokuli a lokela ho hlahlojoa ho bona matla a sebetsang. Haeba sena se sa bonoe, o hloka ho fetola tekanyetso kapa ho fetola mofuta oa kalafo.

Ho sebelisana le lithethefatsi

Setlhare se ka sebelisoa hammoho hammoho le meriana eohle. Mona ke mehlala e meng ea tšebelisano ea eona le meriana e meng:

1. Ka tsamaiso e tšoanang ka li-anticoagulants, phello ea bona ea ntlafatsoa. Sena se ka lebisa ho tsoa mali. Haeba u hloka ho li sebelisa ka nako e le ngoe, joale litekanyetso tsa li-anticoagulants li fokotsoa makhetlo a 3.
2. Fenofibrate ka cyclosporine, ha e kopantsoe hammoho, e baka tsitsipano mosebetsing oa liphio.
3. Ho sebelisoa ka mokhoa o kopanetsoeng le li-fibrate tse ling ho eketsa kotsi ea ho senyeha ka chefo ho mesifa ea mesifa.

Litaelo tse khethehileng

Ho bohlokoa ho ithuta litaelo tse ikhethang pele u sebelisa moriana. Har'a tsona ke:

1. Moriana ha o sebetse haeba o sa felise mafu a ileng a baka keketseho ea maemo a lipid.
2. Ha o sebelisa sethethefatsi sena, o lokela ho latela lijo tse nang le k'holeseterole e fokolang.
3. Ho sebetsa hantle ha kalafo ho ka hlahlojoa ke litholoana tsa tlhahlobo ea mali bakeng sa litaba tsa cholesterol e felletseng, LDL, triglycerides.
4. Haeba mokuli a ntse a sebelisa lithethefatsi tsa lihormone, joale o lokela ho tseba hore na keketseho ea maemo a lipid ha e bakoe ke ho se leka-lekane ha li-hormone.
5. Selemong sa pele sa ho nka moriana, ho khothalletsoa ho beha leihlo boemo ba transpases tsa hepatic (ALT le AST).

Melao ALT le AST

Mehato e joalo e ka eketsa katleho ea moriana, hammoho le ho thibela nts'etsopele ea maikutlo le mathata a mabe.

Litla-morao, matšoao a overdose

Moriana o na le litlamorao tse lekaneng. Hangata li hlaha ka lebaka la tšebeliso ea eona e sa lokelang. Maemong ana, bakuli ba ka ba le:

• Mathata a ho ja, a bonahatsoang ke ho nyekeloa ke pelo, ho hlatsa, bolutu, bohloko ba ka mpeng, lets'ollo,
• pancreatitis
• sebopeho sa majoe ka metsong ea bile,
• nts'etsopele ea hepatitis (e bontšoa ke jaundice, ho hlohlona ha letlalo),
• spasm, bofokoli ba mesifa le ho hlonama,
• Keketseho ea lisele tse tšoeu tsa mali le hemoglobin,
• hlooho e bohloko
• tlhekefetso ea thobalano,
• thromboembolism, leukocytosis,
• ho hloleha ha renal renal
• ts'ebetso ea ho ruruha matšoafong
• tahlehelo ea moriri
• ho arabela ka tlhaho ho letlalo ka mokhoa oa bofubelu, ho hlohlona, ​​rashes, urticaria,
• Photophobia.

Ho sebelisa overdose ka seoelo. Maemong ana, mokuli o lokela ho isoa setsing sa bongaka. Ba kalafo ea matšoao. Ha ho khonehe ho tlosa moriana ka hemodialysis.

Mekhoa e ts'oanang

Fenofibrate e bua ka li-agents tsa hypoglycemic. Mefuta ea eona ea sebopeho e na le ntho e tšoanang e sebetsang. Tse tummeng ka ho fetisisa ho tsona:

1. Tricor ke lithethefatsi tse theko e phahameng ho feta tsa France.
2. Lipantil ke sehlahisoa sa Sefora se nang le 200 mg ea fenofibrate letlapeng le le leng.
3. Exlip ke moriana o tsoetseng pele oa tokollo oa Turkey o nang le 250 mg ea fenofibrate.

Lithethefatsi tse ling li na le likarolo tse ling, empa li na le phello e tšoanang. Har'a tsona ke:

1. Atorvacor. Setlhare se na le ntho e sebetsang ea atorvastatin mme ke inhibitor ea HMG-CoA reductase. E sebelisoa bakeng sa hyperlipidemia.
2. Livostor. Sehlahisoa se boetse se na le atorvastatin. Ke moriana o sa bitseng chelete e ngata ho theola cholesterol ea mali.
3. Tulip. E entsoe ke k'hamphani ea meriana Sandoz naheng ea Poland. Atorvastatin e sebetsa e le ntho e sebetsang.

Chelete e joalo e sebelisetsoa ho mamella ho etsa fenofibrate. Abela analogue kapa e 'ngoe e ka fana ka ngaka feela e teng.

Tlhahlobo ea lingaka le bakuli

Bakeng sa ho lekola katleho ea moriana, ho bohlokoa ho tseba hore na lingaka le bakuli ba tsona ba reng ka Fenofibrate. Litlhahlobo ke tsa 'nete:

Fenofibrate ea lithethefatsi ke setlhare se sebetsang bakeng sa kalafo ea hyperlipidemia. Molemo oa eona o holim'a ho bokelloa ha ntho e sebetsang maling, e lebisang phello e sa feleng - ho fokotseha ha LDL le triglycerides.

Mokhoa oa ho nka Fenofibrate

Matlapa a nooa ntle le ho hlafuna. Bakuli ba baholo ba hloka ho nka karolo ea 145 mg ea moriana ka letsatsi. Ha o fetola tekanyetso ea 165, 180 mg ho lethal dose ea letsatsi le letsatsi ea 145 mg, ha ho hlokahale khalemelo e eketsehileng ea tloaelo ea letsatsi le letsatsi.

Setlhare se khothalletsoa ho nooa nako e telele khahlano le semelo sa phepo e nepahetseng. Katleho ea kalafo e lokela ho hlahlojoa khafetsa ke ngaka e eang ho ea ka litaba tsa serum lipid.

Matlapa a nooa ntle le ho hlafuna.

Tsamaiso ea methapo e bohareng

Ho se sebetse hantle ha hlooho le mathata a hlooho ho ka hlaha ka litlamorao tse chefo tsamaisong ea methapo.

Ka litekanyetso tse fosahetseng tsa moriana, litla-morao li ka hlaha ka mokhoa oa ho tsietsana.
Ka litekanyetso tse fosahetseng tsa moriana, litla-morao li ka hlaha ka mokhoa oa bohloko ba mesifa.
Ka litekanyetso tse fosahetseng tsa moriana, litla-morao li ka hlaha ka mokhoa oa lekhopho letlalong.
Ka litekanyetso tse fosahetseng tsa moriana, litla-morao li ka hlaha ka mokhoa oa keketseho ea phallo ea lisele tse tšoeu tsa mali maling.
Ka litekanyetso tse fosahetseng tsa moriana, litla-morao li ka hlaha.
Ka litekanyetso tse fosahetseng tsa moriana, litla-morao li ka hlaha ka mokhoa oa ho hlatsa.
Ka litekanyetso tse fosahetseng tsa moriana, litla-morao li ka hlaha ka mokhoa oa ho lahleheloa ke moriri.

Ho tsoa ts'ebetsong ea genitourinary

Ha ho na liphetoho tse mpe tšebetsong ea moroto.

Maemong a mangata, ho na le lekhopho la letlalo, ponahalo ea leseli (khanya ea leseli), ho hlohlona kapa hives ea bonolo ho hofeta tekano. Maemong a sa tloaelehang, ho lahleheloa ke moriri, ponahalo ea erythema, lithupa kapa maqhubu a lithane tse sebetsanang le ts'usumetso ea mahlaseli a kotsi a kotsi.

Tšusumetso ho bokhoni ba taolo ea methapo

Ho nka Fenofibrate ha ho ame khatello ea maikutlo, khatello ea 'mele le kelello, ka hona, nakong ea kalafo e theolang lipid, ho khanna koloi le ho sebetsa ka lisebelisoa tse rarahaneng ho lumelloa.

Nakong ea ts'ebeliso ea lithethefatsi, ho khanna koloi le ho sebetsa ka lisebelisoa tse rarahaneng ho lumelloa.

Sebelisa nakong ea bokhachane le pelehi

Lithutong tsa kliniki ho liphoofolo, ha ho na phello ea teratogenic e fumanoeng. Ka litlhahlobo tsa tlhahlobo ea bokhachane, tšebeliso ea chefo ho 'm'a le tšoaetso ho lesea e tlalehiloe, ka hona, moriana o nooa feela ha ts'usumetso e ntle ho mosali oa moimana e feta kotsi ea likotsi tsa intrauterine ho ngoana.

Ho anyesa nakong ea kalafo ho felisitsoe.

Ho laela Fenofibrate ho Bana

Setlhare sena ha se khothaletsoe bana le bacha ba ka tlase ho lilemo tse 18 ka lebaka la tlhaiso-leseling mabapi le phello ea Fenofibrate ho hola le ho holisa 'mele.

Setlhare sena ha se khothaletsoe bana le bacha ba ka tlase ho lilemo tse 18.
Ho anyesa nakong ea kalafo le moriana ho felisitsoe.
Ho nwa moriana nakong ya kemolo ho etswa ha feela phello e ntle ho mosali oa moimana e feta kotsi ea ho senyeheloa ke mpa ho ngoana.

Bongata

Ha ho so be le linyeoe tsa overdose ka lebaka la ts'ebeliso e mpe ea lithethefatsi. Ha ho na karolo e tobileng ea ho hanyetsa. Ka hona, haeba mokuli ea nang le tekanyetso e le 'ngoe ea lethal dose e phahameng a qala ho kula, ho mpefala kapa litla-morao, ho hlokahala hore a batle thuso ea bongaka. Ka ho kena sepetlele, matšoao a boloi a tlisoang a tlosoa.

Ho sebelisana le lithethefatsi tse ling

Ha o kopanya fenofibrate le anticoagulants bakeng sa tsamaiso ea molomo, katleho ea moriana o botsoang e ea eketseha. Ka ts'ebelisano ena, menyetla ea ho tsoa mali e eketseha ka lebaka la ho falla ha anticoagulant ho tsoa liprotheine tsa mali tsa plasma.

Ka tšebeliso e ts'oanang ea li-blockers tsa HMG-CoA tse fokotsang kotsi, kotsi ea ho re ho na le chefo e itseng mesifa ea mesifa ea eketseha, kahoo haeba mokuli a nka li-statins, ho hlokahala hore a hlakoloe lithethefatsi.

Cyclosporine e thusa ho senyeha ha liphio, kahoo ha u nka Fenofibrate, o lokela ho lekola boemo ba 'mele oa hau khafetsa. Haeba ho hlokahala, tsamaiso ea sethethefatsi sa hypolipidemic e hlakotsoe.

Tekanyo ea joala

Nakong ea kalafo le Fenofibrate, ho thibetsoe ka thata ho noa joala. Tai ea Ethyl e nyenyefatsa phello ea kalafo ea moriana, e matlafatsa phello e chefo liseleng tsa sebete, tsamaiso ea methapo e kholo ea mali le phallo ea mali.

Likokoana-hloko tsa lithethefatsi li kenyelletsa lithethefatsi tse nang le ts'ebetso e ts'oanang:

• Tricor
• Atorvacor
• Lipantil
• Cyprofibrate,
• Matlapa a Canon Fenofibrate,
• Livostor
• Hlahisa,
• Trilipix.

Ho fetohela moriana o mong ho etsoa ka mor'a tlhahlobo ea bongaka.

Tricor Commander Lipantil 200 M taelo ea Phenofibrate TOON thuto

Maemo a polokelo ea moriana

Ho khothalletsoa ho boloka moriana ka lithemparetjha ho fihla ho 25-25 C sebakeng se ommeng, se hole le khanya ea letsatsi.

Ho khothalletsoa ho boloka moriana ka lithemparetjha ho fihla ho 25-25 C sebakeng se ommeng, se hole le khanya ea letsatsi.

Tlhatlhobo ea Fenofibrate

Ho na le litlhaloso tse khothatsang tse tsoang ho litsebi tsa meriana le bakuli.

Olga Zhikhareva, ngaka ea methapo ea maikutlo, Moscow

E sebetsa hantle ntoeng khahlanong le triglycerides e phahameng. Ke khothaletsa ho sebelisa mefuta ea IIa, IIb, III le IV hyperlipoproteinemia. Boikoetlisong ba bongaka, ke fana ka taelo ea nako ea tsamaiso le litekanyetso ka bonngoe. Ha ho litla-morao tse ileng tsa bonoa. Ha e na phello e boletsoeng ea ho theola cholesterol.

Afanasy Prokhorov, setsebi sa phepo e nepahetseng, Yekaterinburg

Ka botenya le cholesterol e ngata, fenofibroic acid e thusa hantle. Haholo-holo ka katleho e tlase ea ho ikoetlisa le ho ja. Nakong ea phekolo, ke khothaletsa ho tlohela mekhoa e mebe mme ke latele ka hloko litlhahiso tsa ngaka ho eketsa katleho.

Nazar Dmitriev, ea lilemo li 34, Magnitogorsk

Pheko e ntle. Lipids li ne li le 5.4. Ka tšebeliso ea kamehla ea Fenofibrate, boemo ba mafura bo theohetse ho 1.32. Borderline e ne e le 1,7. Ha ho litla-morao tse boletsoeng.

Anton Makaevsky, ea lilemo li 29, St. Petersburg

O nkile hoo e ka bang selemo sebakeng sa Torvacard ka lebaka la litaba tse tlase tsa HDL. Kamora ho tsamaisoa ka likhoeli tse 4-5, litlhaselo tsa ho nyekeloa le pelo le bohloko ka mpeng e holimo li ile tsa qala ho hlaha. Kamora likhoeli tse 8-9, ba ile ba etsa opereishene ho tlosa gallbladder. Ho fumanoe majoe a viscous bile le a hlephileng. Kamora ts'ebetso, litlhaselo li ile tsa emisa.

Mikhail Taizhsky, ea lilemo tse 53, Irkutsk

Moriana o noele ho matlafatsa marako a methapo, empa ha ke khone ho bua ka ketso. Lijana ha li utloe. Ka thuso ea sethethefatsi, boima ba 'mele bo ile ba fokotseha ka lebaka la tlala, empa letlalo le ile la hlapoloha haholo. Ts'ebetso ea ho khutlisa e hlokahala. Ke khotsofetse ke sephetho.