Melao ea ts'ebeliso ea lithethefatsi Neurorubin

Lebitso la Latin: Neurorubine

Motsoako o sebetsang: Thiamine hydrochloride + Pyridoxine hydrochloride + Cyanocobalamin (Cyanocobalamin + Thiamine hydrochloridum + Pyridoxine hydrochloridum)

Mohlahisi: Wepha GmbH (Jeremane)

Tlhaloso e fetelletse ka nako ea: 02/05/18

Neurorubin ke tlhophiso e boima ea vithamine bakeng sa kalafo ea methapo ea methapo.

Sokolla foromo le sebopeho

Neurorubin e rekisoa ka tsela ea tharollo ea liente le matlapa a koahetsoeng.

Tharollo ea fumaneha ka likhalase tsa khalase tse kentsoeng mabokoseng a karete ea 5 amp.

Matlapa a koahetsoeng a fumaneha ka marang-rang (matlapa a 10 ka 'ngoe), a behiloeng ka har'a mabokose a karete ea 2 likhomphutha.

Matšoao a ho sebelisoa

Matšoao a sebelisoang ke maloetse a latelang:

• Lefu la tsoekere la polyneuropathy.
• Manonyeletso a methapo ea methapo le neuralgia e hlahisoang ke chefo ka lintho tse fapaneng, ho kenyeletsa le lithethefatsi le joala.
• Bohloko ba mefuta e sa foleng le e mpe ea polyneuritis le neuritis.

Tharollo ea entetso

E sebelisoa e le monotherapy kapa hammoho le lithethefatsi tse ling bakeng sa maloetse a joalo:

• Diabetes polyneuropathies.
• Neuropathies (ho kenyelletsa le peripheral, e halefisitsoeng ke joala).
• Neuralgia, ho kenyelletsa neuralgia ea trigeminal le cervicobrachial neuralgia.
• Polyneuritis e matla le e sa foleng le neuritis ea li-etiologies tse fapaneng.
• Mofuta o omileng le o ommeng oa beriberi (boemo bo hlahang ka lebaka la ho haella ha thiamine), vithamine B hypovitaminosis

Contraindication

Contraindication ho e sebelisa ke hypersensitivity ho likarolo tsa constituent. Tharollo ea Neurorubin ha e sebelisoe nakong ea ho beleha ngoana le ho anyesa, hammoho le kalafo ea bana ba ka tlase ho lilemo tse 16.

Setlhare sena se laetsoe ka hloko e kholo ho bakuli ba nang le psoriasis. Meeli ena e amahanngoa le bokhoni ba cyanocobalamin ho holisa psoriasis.

Litlamorao

Tšebeliso ea lithethefatsi Neurorubin e ka baka litlamorao tse latelang:

• Tsamaiso ea methapo e bohareng le e poteletseng: ho tsekela, ho opeloa ke hlooho, bofokoli. Maemong a sa tloaelehang, ho ne ho e-na le maikutlo a ho tšoenyeha, ho eketseha ho sa tsitsang le ho tšoenyeha. Ha o sebelisa lithethefatsi ka tekanyetso e phahameng, ho ka etsahala hore o thehe moralo oa methapo ea kutlo, o nyamelang kamora ho khaotsa lithethefatsi.
• Ts'ebetso ea pelo: Ho oa ho potoloha (ho bonoang feela ho batho ba nang le hypersensitivity ho likarolo tsa moriana), tachycardia.
• Sistimi ea tšilo ea lijo: ho hlaseloa ke ho nyekeloa, ho eketseha ha li-enzyme tsa sebete maling, ho hlatsa. Ho bakuli ba nang le hypersensitivity ea lithethefatsi, ho tsoa mali ho ile ha etsahala.
• Lipontšo tsa ho kula: urticaria, rashes le ho hlohlona ha letlalo. Ha u nka litekanyetso tse kholo tsa moriana, nts'etsopele ea makhopho (makhopho) e ile ea bonoa.
• Tse ling: cyanosis, ho fufuleloa ho eketsehileng, edema ea pulmonary. Bakuli ba nang le hypersensitivity ho lithethefatsi ba na le kotsi ea ho nts'etsapele maikutlo a anaphylactoid (ho kenyeletsa le edema ea Quincke). Ka tšebeliso ea botsoali ho bakuli ba nang le hypersensitivity ho livithamini tsa B, ho na le monyetla oa ho ts'oaroa ha anaphylactic.

Ketso ea pharmacological

Neurorubin ke litokisetso tse rarahaneng tsa vithamine tse nang le livithamini tsa metsi tse sa qhibilihang B. E na le mesebetsi e mengata e fapaneng.

Vitamin B1 e ameha ho metabolism ea carbohydrate, ho deamination le transamination of amino acid, ka hona e laola metabolism ea protheine. Ho metabolism ea mafura, vithamine B1 e laola ho thehoa ha mafura a acid mme e thusa ho fetolela ha lik'habohaedreite hore ebe mafura. Mefuta e sebetsang ea vithamine e etsa hore 'mele o sebetse hantle ka mokokotlong le ho sebetsa ka lekunutu. Vitamin B1 e kenya liteishene tsa ion ka mokokotlong oa lisele tsa methapo ea kutlo, e amang ho kenella ha litšusumetso ho methapo ea methapo.

Vitamin B6 e nka karolo ho kopantsoeng ha li-enzymes, protheine le metabolism ea mafura, e nka karolo litlamorao tse fapaneng tsa enzymatic karolong ea coenzyme. E laola ho hlophisoa ha li-neurotransmitters ka har'a methapo ea methapo e bohareng le e poteletseng, e nka karolo sebopeho sa myelin membrane ea neuron, lipid le metabolism ea protheine, mme e laola ho hlophisoa ha hemoglobin.

Vitamin B12 e bapala karolo ea bohlokoa ho metabolism ea protheine, e laola ho hlophisoa ha li-amino acid, li-purines le li-anemic acid. Hoa hlokahala bakeng sa tsela e tloaelehileng ea ts'ebetso ea neuronal myelination le ho thehoa ha acetylcholine. E khothalletsa phallo e ntle ea methapo ea methapo hammoho le methapo ea methapo ea kutlo le ho khothaletsa ntlafatso ea likhoele tsa methapo. Cyanocobalamin e na le matla a hematopoietic, e hlohlelletsa erythropoiesis, e ntlafatsa hematopoiesis, e lokisa tsamaiso ea methapo ea mali, 'me e thusa ho fokotsa cholesterol maling.

Neurorubin e na le litekanyetso tse phahameng tsa kalafo ea li-vithamine tse kaholimo, tseo ka ho rarahaneng li fetole tšebetso ea methapo ea kutlo le ho laola lipid, carbohydrate le metabolism ea protheine. Motsoako ona oa livithamini tsa B o thusa ho fokotsa bohloko le neuralgia ea mefuta e fapaneng.

Litaelo tse khethehileng

Lintho tse sebetsang tsa tharollo le litafole li tšela mekoallo ea hematoplacental ebe li fetela lebeseng la matsoele. Ha ho na tlhahisoleseling ka polokeho ea ts'ebeliso nakong ea kemaro le ho nyeka. Ka hona, e ka laeloa ke ngaka haeba kotsi e ka bang teng ho lesea e ka tlase ho molemo o lebelletsoeng ho mme. Haeba ho hlokahala ho fana ka moriana nakong ea kanyeso, ho hlokahala ho rarolla bothata ba ho emisa lactation.

Ho sebelisana le lithethefatsi

Ha e sebelisoa hammoho, neurorubin e fokotsa phello ea kalafo ea levodopa. Sena se lokela ho nahanoa ha o phekola batho ba nang le lefu la Parkinson. Ho khothalletsoa hape ho qoba tšebeliso e tšoanang ea meriana ena.

Ka tšebeliso e rarahaneng, lithethefatsi li ntlafatsa chefo ea isoniazid.

Meriana e nang le thepa e koahelang le e koahelang e fokotsa ho monya (ho monya) ha Neurorubin.

Ka lebaka la vithamine B6, eo e leng karolo ea boitokiso, e khona ho fokotsa katleho ea haarretamine ha e sebelisoa hammoho.

Theko ea litlhare tsa meriana

Theko ea Neurorubin bakeng sa sephutheloana se le seng e qala ho li-ruble tse 500.

Tlhaloso e leqepheng lena ke mokhoa o bonolo oa mofuta oa semolao sa semolao. Tlhahisoleseling e fanoe molemong oa tlhaiso-leseling feela mme ha se tataiso bakeng sa kalafo. Pele u sebelisa lithethefatsi, u lokela ho etela setsebi 'me u itloaetse litaelo tse lumellaneng le moetsi.

Pharadodynamics

Motsoako oa lithethefatsi oa vithamine o na le likarolo tse kang pyridoxine, cyanocobalamin le thiamine. E 'ngoe le e' ngoe ea lintho tsena e hlokahala ho etsa lits'ebetso tse fapaneng tse etsahalang ka hare ho 'mele oa motho.

Mohlala, thiamine ke karolo e mafolofolo lits'ebetsong tsa metabolic tse amanang le mafura le lik'habohaedreite (empa eseng liprotheine). Ho haella ha thiamine ho lebisa ho eketseng hoa boleng ba lactate le pyruvic acid. Sesebelisoa sena se sebetsang se khothaletsa borashe, hammoho le ho feto-fetoha ha li-amino acid tse hlokahalang bakeng sa 'mele.

Ka lebaka la lits'ebetso tsena tse etsahalang ka ho nka karolo ha thiamine, metabolism ea protheine e tsitsitse. Ho tlameha ho hopoloa hore elemente e tiisa metabolism ea mafura le sebopeho sa mafura a acid, mme ka ho eketsa e phahamisa ts'ebetso ea thobalano ea mala ka mpeng le ts'ebetso ea matla, ho feta moo, vithamine e sebelisana le marako a sele kahare ho li-neuron mme e tsosa mesebetsi ea liteishene tsa ion.

Pyridoxine, joalo ka thiamine, e sebetsa ka mafolofolo ho metabolism ea mafura le protheine, mme e tlama li-enzyme le eona. Karolo ena ke coenzyme kholisong ea karabelo ea enzymatic. Vitamin A e thusa ho theha lebota la myelin neural mme le ameha phapanyetsanong ea lipids ka liprotheine, 'me hape, ho kopantseng ha hemoglobin le neurotransmitters kahare ho li-synapses tsa tsamaiso ea methapo e bohareng, hammoho le PNS.

Cyanocobalamin e bohlokoa haholo ho metabolism ea protheine, 'me ka nako e ts'oanang e laola tlhahiso ea li-purines tse nang le li-acid tsa acid le amino acid. Vithamine ena e hlokahala bakeng sa 'mele, hobane e ama tlhahiso ea acetylcholine,' me ho kenyelletsa lits'ebetso tsa neural myelination. Hape, karolo ena e ama hantle ho khutlisetsoa ha methapo ea methapo ebile e susumetsa nts'etsopele ea litšusumetso kahare ho NS ea ho putlama.

Vitamin e na le phello ea hematopoietic, e laola k'holeseterole 'me ka nako e ts'oanang e tsosa lits'ebetso tsa erythropoiesis. Cyanocobalamin e thusa ho ntlafatsa lits'ebetso tsa hematopoietic hape e tsitsisa sekhahla sa ho ruruha hoa mali.

Ka kopanelo, livithamini tsena tsohle tse kaholimo li thusa ho tiisa ts'ebetso ea NS ea motho mme ka nako e ts'oanang e na le phello e ntle ho metabolism ea lipids e nang le liprotheine, lik'habohaedreite le mafura.

Ho boetse hoa hlokahala ho ela hloko 'nete ea hore vithamine e joalo e fokotsa haholo bohloko bo hlahisoang ke methapo ea kutlo e nang le etiology e fapaneng.

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Mofumahali

Li-vithamine tse qhibilihang ka metsing li kenngoa ka botlalo ka mor'a ho kenella, thepa e meng ea pharmacokinetic:

• vithamine ea b₁: Karolo ea thiamine e halikiloeng e kenella ho potoloha ha enterohepatic ea acid acid. Ha e fetohe, thiamine e tšolloa ka tekanyo e nyane, haholo e hlahisoa ka mokhoa oa metabolites: thiamincarboxylic acid le pyramine (2,5 dimethyl-4-aminopyrimidine),
• vithamine ea b₆: pyridoxine e ntlafatsoa 'meleng ho ea pyridoxamine kapa oxidised ho pyridoxal; ha coenzyme, pyridoxine e sebetsa e le pyridoxal-5-phosphate (PALP) e hlahisoang ke phosphorylation ea CH₂Sehlopha sa OH se maemong a bohlano, ho fihlela ho 80% PALF e tlama liprotheine tsa plasma, pyridoxine ka sebopeho sa PALF e bokellana haholo-holo linthong tsa mesifa, tse hlahisitsoeng haholo ka sebopeho sa 4-pyridoxic acid,
• vithamine ea b₁₂: kamora ho amoheloa, cyanocobalamin ka serum e tlama boholo ba liprotheine tse joalo - e ikhethang B₁₂-binding β-globulin (transcobalamin) le B₁₂-Binding α1-globulin, vithamine B e eketsehile₁₂ haholo sebeteng, halofo ea bophelo (T_1/2) ho tsoa serum ea mali

Matsatsi a 5, le ho tsoa ho sebete

Tšebelisano

Ha ho kgothaletswe ho nka hammoho neurorubin, Levodopa le Altretamine, kaha motsoako oa vithamine o fokotsa ho sebetsa ha meriana e kaholimo. Ho qoba chefo e eketsehileng Isoniazid se ke ua sebelisa sethethefatsi sena le se thata ka nako e le 'ngoe Li-vithamine tsa B.

Ho bohlokoa ho hopola seo Li-antagonists tsa Vitamin B1 ke lintho tse kang Fluorouracil, hape thiosemicarbazone. Ho fufuleloa Neurorubin Forte Lactab fokotsa lithethefatsi ka thepa ea antacidle ho fana phello e koahelang.

Nakong ea bokhachane le pelehi

Ho tloha ka ya data ka polokeho e felletseng ea lithethefatsi bakeng sa moimana mme ha ho na basali ba fanang ka lode, Neurorubin e thibetsoe ho e sebelisa nakong e boletsoeng ka holimo. Leha ho le joalo, ngaka e eang teng e ka fana ka motsoako oa vithamini ho mosali oa moimana haeba ho hlokahala haholo kalafong ea bongaka mme ka tebello feela ea hore phaello e reriloeng e tla ba holimo haholo ho feta kotsi e ka hlahang.

Haeba ho hlokahala, ts'ebeliso ea neurorubin nakong lebonekgothaletswa ho emisa sefubaha kgokelo e hlolahematoplacental barriers 'me e fetola sebopeho sa lebese la matsoele, se ka amang maemo a bophelo a lesea hantle.

Moriana o behiloe neng?

Matšoao a ka sehloohong a ts'ebeliso:

• Wernicke-Korsakoff syndrome, peripheral neuropathy le methapo e meng e amanang le tahi e sa foleng,
• nka mofuta o omileng le o metsi,
• lefu la tsoekere la polyneuropathy.

E le karolo ea kalafo e sebetsang, e sebelisoa bakeng sa:

• neuritis e sa foleng le e sa foleng le polyneuritis,
• cervicobrachialgia le trigeminal neuralgia.

Thibelo ea lithethefatsi

Maemong moo lithethefatsi li kotsi bakeng sa kalafo ea bakuli:

1. Pheko e ka sehloohong ea ho sebelisa litlhare ke kutloelo-bohloko ea 'mele, haholo-holo ho vithamine B6.
2. Vitamin B12 ha e khothalletsoe batho ba nang le psoriasis, kaha e ka baka ho mpefala ha matšoao a lefu lena.
3. Se ke oa sebelisa moriana oa basali ba bakhachane le bo-'mè ba anyesang. Har'a lintho tse hanyetsanoang ke lilemo tsa bana.

Tekanyetso le tsela ea tsamaiso

Maemong a tsoetseng pele, Neurorubin ea lithethefatsi e beoa ka makhetlo a mangata ka tsatsi le leng le le leng ho fokotsa lipontšo tsa bohloko. Maano a joalo a lebelletsoe qalong ea kalafo. Hamorao, bakuli ba fuoa li-ampoules tse 1-2 makhetlo a mabeli ka beke.

Mokhoa o sebelisang:

1. Tsamaisa ampoule ka ho tšoaea. E bontšoa joalo ka letheba.
2. Shake hantle hore mokelikeli o abeloe ka mokhoa o lekanang.
3. Khaola hlooho ea sehlahisoa e ka holim'a matšoao.

Monyetla oa ho overdose

Ho nka tekanyetso e ngata ea vithamini ea molomo ea B6 ka bongata ba 500 mg kapa ho feta bakeng sa likhoeli tse 5 ho ka lebisa ho karabelo e kotsi. Boholo ba lithethefatsi hangata bo tsamaisoa ke:

• karabelo
• peripheral reversible sensor neuropathy.

Neuropathy hangata e fokotseha ka mor'a ho tlohela lithethefatsi.

Lintho tse fapaneng tse tla etsahala

Ho nka meriana ho ka tsamaisana le litla-morao tse joalo:

1. Sistimi ea endocrine: thibelo ea ts'ebeliso ea prolactin.
2. Sistimi ya mmele ya mmele: ka seoelo - allergy ea mofuta oa erythema ea polymorphic, angioedema, tšobotsi e ikhethang ho batho ba nang le kutloisiso ea motho ka mong likarolo tsa moriana. Nako le nako, ka mor'a ho kenella ka har'a ente ea li-vithamine ka har'a intra ea methapo, ho ka etsahala hore ho ts'oaroa ha anaphylactic ho be teng. Phekolo ea matšoao e kenyelletsa tšebeliso ea li-antihistamines.
3. Ts'ebetso ea methapo ea pelo: edema ea pulmonary e etsahalang ho batho ba nang le kutloisiso ea likarolo, cyanosis, tachycardia esita le ho oa le eona e ka etsahala.
4. Ka lehlakoreng la letlalo: urticaria le ho hlohlona, ​​tse tsejoang ka batho ka bomong. Makhopo a hlaha ho bakuli ba fuoeng tekanyetso e eketsehileng ea moriana. Pyridoxine e baka ponahalo ea makhopho a macha, hammoho le ho phatlalatsoa ha makhopho sefahlehong.
5. Litlamorao tse tloaelehileng: bofokoli, ho tsekela, ho fufuleloa.

Hangata bakuli ba na le letsoalo la ho tšoenyeha ka mor'a ho nka Neurorubin. Ho masea a sa tsoa tsoaloa a nang le khaello ea vithamini ea B12, linyeoe tsa ho sisinyeha ho sa ikemisetsa li tlalehiloe kamora kalafo.

Menahano ea lithethefatsi

Ka li-analogues ho lokela ho utloisisoa lithethefatsi tse nang le lebitso le tšoanang la machaba, le sa ameheng. Ho bohlokoa ho utloisisa hore pele o fetola Neurorubin ka analogue, o lokela ho bona ngaka ea hau. Litšoantšo tse ka sehloohong:

1. Vitaxon. E sebelisoa bakeng sa khaello ea livithamini B1 le B6 e sebetsang khahlano le mafu a methapo.
2. Neurobion. E sebelisoa ho kalafo ea neuralgia neuritis, ho kenyelletsa le trigeminal neuralgia, intercostal neuralgia. Tse ling tsa matšoao a tsona ke radicular neuritis, liphetoho tse ling tse amanang le ho hlophisoa bocha ha lesapo la mokokotlo, e leng sekoli sa sefahleho sa mokokotlo.
3. Neuromax. Li-pathologies tsa Neurological tse amanang le tlhaiso e netefalitsoeng ea tlhahlobo ea li-vithamine B1 le B6.
4. Neuromultivitis. E sebetsa hantle bakeng sa polyneuropathy, mafu a methapo ea methapo e sa tšoaneng, neuralgia le neuritis, radiculoneuritis e bakiloeng ke ho fokola ka sebopeho sa lesapo la mokokotlo, ka ho holofala le lesapo la mokokotlo, "sciatica", "patostalal neuralgia".
5. Nerviplex. Har'a matšoao a teng ke khaello ea livithamini tsa B1, B6, B12, lefu la tsoekere, methapo ea kutlo ea methapo, lesapo la methapo ea sefahleho, methapo ea methapo ea kutlo.
6. Neurobeks. E sebelisoa bakeng sa liphetoho tse mpefatsang methapong ea methapo, mafu a sa foleng a bakoang ke liphetoho tse bang teng 'meleng ka lebaka la lefu la tsoekere, moemeli ea tšoaetsanang le joala. Har'a matšoao ke polyneuropathies, osteochondrosis, sciatica, lumbago, likotsi tse mpe, lefu la vegetovascular dystonia. E sebelisoa litlhare tse kopaneng tsa vithamine B1, B6, B12 hypovitaminosis, le glaucoma. macular degeneration, pruritus ea li-etiology tse fapaneng.
7. Unigamm E sebelisoa ho phekolo ea matšoao a mafu a methapo ea methapo e sa tšoaneng. Sena ke sesebelisoa se setle ho loants'eng le mafu a mpefatsang a lesapo la mokokotlo, cervical syndrome, lumbago.

Theko ea mefuta e fapaneng ea tokollo:

1. Matlapa a koahetsoeng a Neurobion ka bongata ba likotoana tse 20 ka pakete e ka rekoa ka theko e tloaelehileng ea li-ruble tse 280-300.
2. Tharollo ea ente ea methapo ea methapo e 3 ea pakete ea 3 ml le eona e rekisoa. Theko ea bona e ka ba li-ruble tse 280.

Litlamorao

• Sistimi ea pelo: maemong a thoko - ho oa, tachycardia, cyanosis,
• Tsamaiso ea methapo e bohareng: ho tšoenyeha, ho thothomela, ho utloahala "hlaba" ka 'metso ", matšoenyeho, ho tsekela,
• Sistimi ea tšilo ea lijo: ho nyekeloa ke pelo, ho tsoa mali ka mpeng, ho eketsa tšebetso ea plasma ea aspartate aminotransferase,
• Endocrine Sisteme: thibelo ea tlhahiso ea prolactin,
• Sistimi ea ho hlasimoloha: edema ea pulmonary, bokhutšoanyane ba moea,
• Letlalo: Makhopho,
• Litlamorao: ho hlohlona, ​​urticaria, edema ea Quincke, ho ts'oaroa ha anaphylactic,
• Mmele ka kakaretso: maikutlo a bofokoli, ho fufuleloa ka tšohanyetso, hyperemia ea sefahleho, feberu.

Bongata

Tekanyetso e feteletseng ea Neurorubin e matlafatsa matšoao a joalo a litla-morao tse kang ho fetoha ha pelo, ho tsekela, ho tsitsipana.

Lintho tse ka etsahalang haeba ho na le lithethefatsi tse ngata tse ngata tsa ramatiki ea B:

• vithamine ea b₁: ka lebaka la mefuta e mengata ea phekolo ea thiamine, ha e nooa ka tekanyetso e phahameng haholo (tse fetang 10,000 mg), ts'ebetso ea methapo ea methapo e hatelletsoe, e senola phello ea mokokotlo,
• vithamine ea b₆: pyridoxine e na le chefo e tlase haholo, empa ts'ebeliso ea eona ho litekanyetso tse phahameng (tse fetang 1000 mg ka letsatsi) e ka bonts'a phello ea methapo ka likhoeli tse 'maloa, kamora ho tsamaisoa ka tekanyetso ea letsatsi le letsatsi ea ho feta 2 mg mg, karabelo e kang neuropathy le ataxia le ho lemala ha methapo ea kutlo li ile tsa hlalosoa, ho ts'oaroa ha mokokotlo ka liphetoho ho electroencephalogram, maemong a mang, seborrheic dermatitis le hypochromic anemia li ile tsa bonoa,
• vithamine ea b₁₂: kamora hore batsamaisi ba tsamaiso ea cyanocobalamin ho litekanyetso li feta tekanyo e khothalelitsoeng, hypersensitivity reaction, sebopeho sa benche le makhopho a letlalo la eczematous li ile tsa bonoa maemong a sa tloaelehang, tšebeliso ea nako e telele ea litekanyetso tse phahameng e ka baka ts'ebetso e mpe ea li-enzyme tsa sebete, hypercoagulation, bohloko pelong.

Haeba u belaella hore tekanyetso e khothalelitsoeng e fetisitsoe, o lokela ho khaotsa ho sebelisa Neurorubin mme, haeba ho hlokahala, kalafo ea matšoao.