Vozulim-N (Vozulim-N)

1 ml ea lithethefatsi e na le:

ntho e sebetsang: insulin (genetic engineering) 100 ME (4.00 mg),

Baeti: protamine sulfate 0,40 mg, zinc oxide 0,032 mg, metacresol 1.60 mg, phenol 0.65 mg, glycerol 16.32 mg, sodium phosphate disubstituted anhydrous 2.08 mg, sodium hydroxide 0.40 mg, hydrochloric acid 0, 00072 ml, metsi a ente ho fihla ho 1 ml.

Ho emisoa ka bosoeu, eo, ha e eme, e fetela ka har'a 'mala o hlakileng, o se nang' mala kapa o batlang o se na 'mala le moea o mosoeu. Ha e le hantle pula e khutla habonolo ha e sisinngoa ka bonolo.

Mofumahali

Phethahatso ea ho kenella ka botlalo le ho qala ha phello ea insulin ho latela tsela ea tsamaiso (ka mokhoa o ikhethileng, intramuscularly), sebaka sa tsamaiso (mpa, thipa, li-buttocks), lethal dose (boholo ba insulin e kenelletseng), mokokotlo oa insulin ho lithethefatsi, joalo-joalo e ajoa ka mokhoa o sa lekanang lithong tsohle tsa mmele mme o sa tšele mokelikeli oa placental. le ka lebese la matsoele. E senngoa ke insulinase haholo-holo ka har'a sebete le liphio. E hloekisoa ke liphio (30-80%).

Bokhachane le pelehi

Ha ho na lithibelo ho kalafo ea lefu la tsoekere le "insulin" nakong ea kemolo, hobane insulin ha e tšele mekoallo ea placental. Ha u rera ho ima le nakong ea eona, hoa hlokahala ho matlafatsa kalafo ea lefu la tsoekere. Tlhokahalo ea insulin hangata e fokotseha ho "trimester" ea pele ea bokhachane mme butle-butle e eketseha ho li-trimesters tsa bobeli le tsa boraro.

Nakong ea ha lesea le hang kamora ho hlaha, litlhoko tsa insulin li ka theoha haholo. Nakoana kamora ho hlaha, tlhoko ea insulin kapele e khutlela boemong bo neng bo le pele ho ima.

Ha ho na lithibelo ho kalafo ea lefu la tsoekere le "insulin" nakong ea ho anyesa. Leha ho le joalo, ho ka hlokahala hore u fokotse tekanyetso ea insulin, ka hona, ho hlahloba ka hloko bakeng sa likhoeli tse 'maloa hoa hlokahala pele ho tiisa tlhokahalo ea insulin.

Tekanyetso le tsamaiso Vozulim-N ka mokhoa oa ho emisoa

Setlhare sena se etselitsoe tsamaiso e tsamaisang botsitso.

Tekanyetso le nako ea ts'ebetso ea lithethefatsi li khethoa ke ngaka ka bonngoe boemong bo bong le bo bong, ho ipapisitse le khatello ea tsoekere maling. Ka karolelano, tekanyetso ea letsatsi le letsatsi ea lithethefatsi e tloha ho 0.5 ho isa ho 1 IU / kg boima ba mmele (ho latela litšobotsi tsa motho ka mong le khatello ea tsoekere ea mali).

Mocheso oa "insulin" o sebelisoang o lokela ho ba ka mocheso oa kamore.

Hangata moriana o tsamaisoa ka mokhoa o potelletseng ka thipa. Ho entoa ho ka etsoa le kahara mpa ea mpa ea mpa, kapa mahetleng ka mokokotlong oa mesifa e boreleli. Hoa hlokahala ho fetola sebaka sa ente kahare ho sebaka sa anatomical ho thibela nts'etsopele ea lipodystrophy.

Vozulim-N e ka tsamaisoa e le mong kapa e le hammoho le insulin (Vozulim-P).

Sebelisa cartridge e nang le pene ea syringe feela.

Sehlopha sa mahlale

Tlohela maikutlo a hau

Lenaneo la Hona Joale la Lintlha

Lithethefatsi tse Ngotsoeng tsa Bohlokoa le Tse Hlokahalang

Setifikeiti sa ho ingolisa Vozulim-N

• LP-000323

Webosaete ea semmuso ea k'hamphani RLS ®. Encyclopedia ea mantlha ea lithethefatsi le thepa ea bongaka ea semmuso ea Marang-rang ea Russia. Lenane la lithethefatsi Rlsnet.ru le fa basebelisi monyetla oa ho fumana litaelo, litheko le litlhaloso tsa lithethefatsi, tlatsetso ea lijo, lisebelisoa tsa bongaka, lisebelisoa tsa bongaka le lihlahisoa tse ling. Tataiso ea meriana e kenyelletsa tlhahisoleseling mabapi le sebopeho le mofuta oa tokollo, ts'ebetso ea meriana Sesebelisoa sa lithethefatsi se na le litheko tsa meriana le lihlahisoa tsa meriana ho la Moscow le metseng e meng ea Russia.

Ho thibetsoe ho fetisa, ho kopitsa, ho tsamaisa tlhahisoleseling ntle le tumello ea RLS-Patent LLC.
Ha u qotsa lisebelisoa tsa tlhahisoleseling tse phatlalalitsoeng maqepheng a sebaka sa marang-rang sa www.rlsnet.ru, ho hokela mohloli oa mohloli oa tlhaiso-leseling.

Lintho tse ling tse ngata tse khahlang

Litokelo tsohle li sirelelitsoe.

Ts'ebeliso ea thepa ea khoebo ha e lumelloe.

Tlhahisoleseling ena e etselitsoe litsebi tsa bongaka.

Litla-morao tsa meriana

Ka lebaka la phello ea metabolism ea carbohydrate: maemo a hypoglycemic (pallor ea letlalo, ho fufuleloa ho eketsehileng, palpitations, ho thothomela, tlala, ho ruruha, paresthesia ea mucosa ea molomo, hlooho). Hypoglycemia e matla e ka lebisa ho hola ha mesifa ea hypoglycemic.

Litla-morao: lekhopho la letlalo, edema ea Quincke, e sa tloaelehang haholo - ho ts'oaroa ha anaphylactic.

Boitšoaro ba lehae: hyperemia, ho ruruha le ho hlohlona sebakeng sa ente, ka tšebeliso ea nako e telele - lipodystrophy sebakeng sa ente.

Tse ling: ho ruruha, liphoso tsa nakoana tse khothatsang (hangata qalong ea kalafo).

Bongata

Ha u e-na le overdose, hypoglycemia e ka hlaha.

Phekolo: mokuli a ka tlosa hypoglycemia e bonolo ka ho nka lijo tse tsoekere tse nang le tsoekere. Ka hona, ho khothalletsoa hore bakuli ba nang le lefu la tsoekere ba nke tsoekere, liswiti, likuku kapa lero le monate la litholoana le bona.

Maemong a tebileng, ha mokuli a lahleheloa ke kelello, 40%, tharollo ea dextrose (tsoekere) e fanoa kahare, ka methapo, ka tšohanyetso, kahare - ka glucagon. Kamora ho hlaphoheloa kelellong, mokuli o khothalletsoa ho ja lijo tse nang le lik'habohaedreite ho thibela nts'etsopele ea hypoglycemia.

Tšebelisano

Ka meriana ha a lumellane le tharollo ea lithethefatsi tse ling.

Hona le lithethefatsi tse 'maloa tse amang tlhokahalo ea insulin.

Phello ea hypoglycemic ea insulin e matlafatsoa khetha beta-blockers, quinidine, quinine, chloroquine, inhibitors monoamine dihydrobenzophenanthridine, angiotensin fetola inhibitors potlakisang tsebetso ea lik'hemik'hale, k'habone anhydrase inhibitors, octreotide, bromocriptine, sulfonamides, anabolic steroid, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, lithium, lithethefatsi e nang le ethanol.

Hypoglycemic phello ea insulin ea fokolisa glucagon, khōlo hormone, estrogens, molomo lithibela-pelehi, steroid, iodinated thyroid li-hormone, thiazide diuretics, sekgoqetsane diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazol, clonidine, sulfinpyrazone, epinephrine, blockers tsa H1-histamine receptor blockers "lieha" k'halsiamo metjha e, diazoxide , morphine, phenytoin, nikotine.

Reserpine, salicylates li ka ntlafatsa le ho fokolisa phello ea hypoglycemic ea insulin.

Mokhoa oa ho sebelisa: litekanyetso le kalafo

Tekanyetso le tsela ea tsamaiso ea Vosulima-R e khethoa ka bonngoe maemong ohle a lefu la tsoekere maling maling pele ho lijo le lihora tse 1-2 ka mor'a lijo, hape ho latela tekanyo ea glucosuria le litšobotsi tsa nako ea lefu lena.

Setlhare se fanoa ka s / c, ka / m, ka / ka, metsotso e 15-30 pele ho lijo. Mokhoa o tloaelehileng oa tsamaiso ea Vosulima-R ke s / c. Ka lefu la tsoekere, "lefu la tsoekere," lefu la tsoekere, nakong ea ts'ebetso ea bongaka e kenellang - ka / in le / m.

Ka monotherapy, hangata khafetsa ea tsamaiso ka makhetlo a 3 ka letsatsi (haeba ho hlokahala, ho fihlela makhetlo a 5-6 ka letsatsi), sebaka sa ente se fetoloa nako le nako ho qoba nts'etsopele ea lipodystrophy (atrophy kapa hypertrophy ea mafura a subcutaneous).

Karolelano ea litekanyetso tsa letsatsi le letsatsi ke 30-40 IU, ho bana - 8 IU, ebe ka karo-karolelano lethal dose ea letsatsi le letsatsi - 0.5-1 IU / kg kapa 30-40 IU makhetlo a 1-3 ka letsatsi, haeba ho hlokahala - makhetlo a 5-6 ka letsatsi . Ka tekanyetso ea letsatsi le letsatsi e fetang 0,6 U / kg, insulin e lokela ho fanoa ka mokhoa oa liente tse 2 kapa ho feta libakeng tse fapaneng tsa 'mele. Hoa khoneha ho kopanngoa le li-insulin tse nkang nako e telele.

Tharollo ea Vozulima-R e bokelloa ho tloha vial ka ho phunya ka nale e silang e le 'ngoe ea sekirini, e emisitsoeng ka mor'a ho tlosa hlooho ea aluminium ka ethanol.

Ketso ea pharmacological

Insulin ea motho ea ntseng a pheta-pheta. Ke insulin ea nako e mahareng ea ketso. E laola metabolism ea glucose, e na le litlamorao tsa anabolic. Ka mesifa le lisele tse ling (ntle le boko), insulin e potlakisa ho tsamaisoa ho hoholo ha tsoekere le amino acid, hape e ntlafatsa anabolism ea protheine. Vosulim-P e khothaletsa phetoho ea tsoekere ho glycogen bokong, e thibela gluconeogeneis mme e hlohlelletsa phetoho ea glucose e feteletseng ho mafura.

Litlamorao

Ho tsoa tsamaisong ea endocrine: hypoglycemia.

Hypoglycemia e matla e ka lebisa ho lahleheloe ke letsoalo le (maemong a ikhethang) lefu.

Litla-morao: Ho ka ba le lintho tse ngata tse ka etsang hore ho be le mathata 'meleng - ho ruruha, ho ruruha kapa ho hlohlona sebakeng sa ente (hangata ho emisa ka nako ea matsatsi a' maloa ho isa ho libeke tse 'maloa). , ho fokotseha ha khatello ea mali, ho eketseha ha pelo, ho eketsa mofufutso. Ho na le maemo a mang a mangata a itseng a ka re utloisang bohloko.

Litaelo tse khethehileng

Ho fetisoa ha mokuli ho ea ho mofuta o mong oa insulin kapa tokisetso ea insulin e nang le lebitso le fapaneng la khoebo ho lokela ho etsahala tlasa tlhokomelo ea bongaka e thata.

Liphetoho ts'ebetsong ea insulin, mofuta oa eona, mefuta (porcine, insulin ea motho, analogue ea insulin ea motho) kapa mokhoa oa tlhahiso (DNA recombinant insulin kapa insulin ea tlhaho ea liphoofolo) e ka hloka phetoho ea tekanyetso.

Tlhokahalo ea tokiso ea litekanyetso ea Vosulima-R e ka hlokoa nakong ea ts'ebetso ea pele ea tokisetso ea insulin ea motho kamora tokiso ea insulin ea liphoofolo kapa butle-butle ho feta libeke tse 'maloa kapa likhoeli kamora ho fetisoa.

Tlhokahalo ea insulin e ka fokotseha ka ho se sebetse hantle ha adrenal function, pituitary kapa gland ea thyme, ka ho se leka-lekane ha renal kapa hepatic.

Ka bokuli bo itseng kapa khatello ea maikutlo, tlhoko ea insulin e ka eketseha.

Phetoho ea mori le eona e ka hlokahala ha o eketsa ho ikoetlisa kapa ha o fetola lijo tse tloaelehileng.

Fomu ea ho lokolla, ho paka le ho hlophisoa

Tharollo ea entetso.

3 ml - li-cartridge (1) - lipakete tsa blister (1) - liphutheloana tsa karete.
10 ml - libotlolo tsa khalase (1) - mabokose a karete.

Melemo ea litekanyetso

Tekanyetso le tsela ea tsamaiso ea moriana e khethoa ka bonngoe maemong ka seng ho latela lethathamo la tsoekere maling maling pele ho lijo le lihora tse 1-2 kamora ho ja, hape ho latela tekanyo ea glucosuria le litšobotsi tsa nako ea lefu lena.

E le molao, s / c e fanoa metsotso e 15-20 pele ho lijo. Litsi tsa ente e fetoloa nako le nako. Haeba ho hlokahala, tsamaiso ea IM kapa IV e lumelloa.

E ka kopanngoa le li-insulin tse nkang nako e telele.

Litla-morao

Boitlhotlhollo ba ho kulisa: urticaria, angioedema, feberu, ho hema hanyane, ho fokotse khatello ea mali.

Ho tloha tsamaisong ea endocrine: hypoglycemia e nang le lipontšo tse kang pallor, ho fufuleloa ho eketsehileng, palpitations, likhathatso tsa boroko, ho thothomela, mathata a methapo, tšitiso ea methapo ea mali le insulin ea motho, keketseho ea karolo ea lithibela-mafu tsa anti-insulin ka keketseho e latelang ea glycemia.

Ho tloha lehlakoreng la setho sa pono: ho fokola ha nakoana ponong (hangata qalong ea kalafo).

Boitšoaro ba lehae: hyperemia, ho hlohlona le lipodystrophy (atrophy kapa hypertrophy ea mafura a tlotsitsoeng) sebakeng sa ente.

Tse ling: qalong ea kalafo, edema ea khonahala (feta ka kalafo e tsoelang pele).

Bokhachane le pelehi

Nakong ea kemolo, ho hlokahala hore ho nahane ka ho fokotseha ha tlhoko ea insulin ho trimester ea pele kapa keketseho ea li-trimesters tsa bobeli le tsa boraro. Nakong ea ha lesea le hang kamora ho hlaha, litlhoko tsa insulin li ka theoha haholo.

Nakong ea ho nyekeloa, mokuli o hloka ho hlahlojoa letsatsi le leng le le leng ka likhoeli tse 'maloa (ho fihlela ho tsitsa ha tlhoko ea insulin).

Ho sebelisana le lithethefatsi

Phello ea hypoglycemic e ntlafatsoa ke li-sulfonamides (ho kenyeletsa le lithethefatsi tsa molomo tsa hypoglycemic, sulfonamides), li-inhibitors tsa MAO (ho kenyeletsoa furazolidone, procarbazine, selegiline), carbonic anhydrase inhibitors, li-inhibitors tsa ACE, li-NSAIDs (ho kenyeletsa le salicylides), anabolic (ho kenyelletsa stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, litokisetso tsa lithium, pyridoxine, quinidine, quinine, chloro, chinine.

Glucagon, GCS, histamine H 1 li-receptor blockers, lithibela-pelehi tsa molomo, li-estrogens, thiazide le "loop" diuretics, li-blockers tse liehang tsa calcium, li-sensathomimetics, lihomone tsa qoqotho, li-antidepressants tsa hepatin, morphine diazropin li fokotsa phello ea hypoglycemic. , matekoane, nikotini, phenytoin, epinephrine.

Beta-blockers, reserpine, octreotide, pentamidine ka bobeli li ka ntlafatsa le ho fokotsa phello ea hypoglycemic ea insulin.

Ts'ebeliso e ts'oanang ea beta-blockers, clonidine, guanethidine kapa reserpine e ka pata matšoao a hypoglycemia.

Ka meriana ha a lumellane le tharollo ea lithethefatsi tse ling.

Fomu ea tokollo, sebopeho le sephutheloana

Ke ho emisoa bakeng sa tsamaiso e poteletseng. 1 ml ea motsoako e na le "insulin" ea insulin ea motho (70%) le insulin-isophan (30%) tse sebelisang mafura. Hape, sebopeho sa moriana o kenyeletsa likarolo tse thusang:

• metsi a ente - 1 ml,
• sodium phosphate (e tsoakiloeng dihydrate) - 2.08 mg,
• protamine sulfate - 0,4 mg,
• glycerol - 16.32 mg,
• metacresol - 1,60 mg,
• zinc oxide - 0,032 mg,
• hydrochloric acid - 0,00072 ml,
• sodium hydroxide - 0,4 mg,
• crystalline phenol - 0,65 mg.

Ke tharollo e tšoeu, eo nakong ea polokelo e kengoang le boputsoa bo bosehla bo boputsoa bo se nang 'mala. Ha e sisinngoa, e khutlela ho emisoa

Sesebelisoa se kenngoa ka botlolong ea khalase ea khalase ea 10 ml, e behiloeng ka lebokoseng la karete.

Ka karolelano - li-ruble tse 1200.

Litaelo tsa ho sebelisoa (mokhoa le litekanyetso)

"Vozulim" e reretsoe ho kenyelletsa mafura a subcutaneous. Tekanyetso le nako ea ts'ebeliso li khethoa ke ngaka e eang ho latela matšoao a tsoekere e maling. Ka tloaelo, tloaelo ea letsatsi le letsatsi e fapana ho tloha ho 0,5 ho isa ho 1 IU / kg ho latela litšobotsi tsa motho ka mong.

Mocheso oa ho emisoa o lokela ho ba mocheso oa kamore. Sebaka se tloaelehileng sa taolo ke mafura a tšesaane a potolohileng. Ho kenella sebakeng sa mokokotlo oa "deltoid mesifa", lebota le kahare la mpa le marapo li lumelletsoe.

TLOTLISO Ho hlokahala hore nako le nako u fetole sebaka sa ente sejoang ho thibela lipodystrophy.

Bakuli ba nang le mofuta oa lefu la tsoekere la mofuta oa 2 ba ka phekoloa le Vozulim hammoho le lithethefatsi tse ling tsa hypoglycemic (tšebeliso ea molomo), hammoho le monotherapy.

Tšusumetso ho bokhoni ba ho khanna transp. Wed le boea.

Mabapi le sepheo sa mantlha sa insulin, phetoho ea mofuta oa eona kapa boteng ba khatello e kholo ea 'mele kapa ea kelello, hoa khoneha ho fokotsa bokhoni ba ho khanna koloi kapa ho laola mekhoa e fapaneng, hammoho le ho etsa lintho tse ling tse ka bang kotsi tse hlokang tlhokomelo e potlakileng le lebelo la karabelo ea kelello le koloi.