Dalacin C.

Sehloohong sena, o ka bala litaelo tsa ho sebelisa lithethefatsi Dalacin. E fana ka maikutlo a tsoang ho baeti sebakeng sena - bareki ba moriana ona, le maikutlo a litsebi tsa bongaka mabapi le tšebeliso ea Dalacin e thibelang likokoana-hloko ts'ebetsong ea bona. Kopo e kholo ke ho kenyelletsa maikutlo a hau ka sethethefatsi sena: moriana o thusitseng kapa o sa thusa ho felisa lefu lena, hore na ho bile le mathata afe kapa afe, mme mohlomong a sa phatlalatsoe ke moetsi ho phatlalatso. Dalacin analogues moo ho nang le li-analogues tsa sebopeho tse fumanehang. Sebelisa bakeng sa kalafo ea makhopho (makhopho), feberu e khubelu, tonsillitis le tšoaetso e 'ngoe ho batho ba baholo, bana, esita le nakong ea kemaro le ho nyeka. Sebopeho sa moriana.

Dalacin - motsoako o thibelang likokoana-hloko oa sehlopha sa li-linkosamide, o thehiloeng ho lincomycin ha sehlopha sa 7- (R) -hydroxyl se nkeloa sebaka ke 7- (S) -chlor, se sebetsang khahlanong le likokoana-hloko tsa aerobic gram-positive le libaktheria tse fapaneng tsa anaerobic. Libaktheria tse ngata tse mpe tsa aerobic, ho kenyelletsa le Enterobacteriaceae, li khahlanong le clindamycin.

Litsosamides, joalo ka li-macrolides (kk., Erythromycin), li tlama karolo ea 50S ea motsoako oa kokoana-hloko le thibelo ea protheine maemong a pele. Ho ipapisitse le sensitivity ea microorganism le khatello ea meriana, clindamycin e ka sebetsa ka bacteriostatically (haholo-holo) kapa bactericidal (maemong a phahameng haholo).

Likokoana-hloko tse latelang li amehile ka clindamycin in vitro:

1. Aerobic gram-positive cocci, ho kenyelletsa: Staphylococcus aureus, Staphylococcus epidermidis (litšila li hlahisa ebile ha li hlahise penicillinase). Ho ile ha hlokomeloa (in vitro) kholo e potlakileng ea ho hanyetsa clindamycin maemong a mang a emisang stryylococcal erythromycin. Streptococcus spp. (ntle le Streptococcus faecalis), Pneumococcus spp.

2. bacer ea anaerobic gram-negative, ho kenyeletsoa: Bacteroides spp. (ho kenyeletsoa sehlopha sa B. fragilis, B. disiens, B. bivius le B. melaninogenicus), Fusobacterium spp.

3. Anaerobic gram-positive, non-spore e etsa bacilli, ho kenyelletsa Propionibacterium spp., Eubacterium spp., Actinomyces spp.

4. Anaerobic le microaerophilic gram-positive cocci, ho kenyelletsa le Peptococcus spp., Peptostreptococcus spp., Microaerophilic Streptococcus spp., Clostridia spp: Clostridia li hanela clindamycin ho feta li-anaerobes tse ling. Boholo ba Clostridium perfringens li na le bothata ho clindamycin, empa mefuta e meng, joalo ka C. sporogenes le C. tertium, hangata e hanyetsana le clindamycin, ka hona liteko tsa kutloisiso li tlameha ho etsoa.

5. Likokoana-hloko tse fapaneng, ho kenyeletsoa Chlamydia trachomatis, Toxoplasma gondii, Plasmodium falciparum le Pneumocystis carinii (hammoho le primaquin), Gardnerella vaginalis, Mobiluncus mulieris, Mobiluncus pelaisii, Mycoplasma hominis.

Likokoana-hloko tse latelang hangata li loants'oa ke clindamycin: aerobic gram-negative bacilli Streptococcus faecalis, Nocardia spp., Neisseria meningitidis, mathata a methicillin a thibelang Staphylococcus aureus le likarolo tsa feberu ea Haemophilus. Ho hanyetsa ka sefapano ho teng lipakeng tsa lincomycin le clindamycin.

Sebopeho

Clindamycin + bakuli.

Mofumahali

Kamora ho tsamaisoa ka molomo, ho kenngoa ka mokhoa o potlakileng le hoo e ka bang ka botlalo (90%) oa dalacin ho etsahala. Ha ho nooa ka molomo, ho kenngoa ha clindamycin (ka bongata) ha hoa itšetleha ka tekanyo e kholo ea ho kenella ha lijo ka nako e le 'ngoe, empa ho kenella ka lijo ho ka liehisa ho monya. Ho na le kamano e teng pakeng tsa khatello ea "clindamycin" serum le tekanyetso ea moriana o nkuoeng. 40-90% ea lithethefatsi tse tsamaisitsoeng e tlama liprotheine tsa 'mele. Clindamycin ha e kene kahare ho mothapo o liseleng tsa mali-bokong (BBB) ​​(esita le ka ho ruruha ha meninges, permeability e eketseha hanyane). Ka sebopeho se sa fetoheng, hoo e ka bang 10% ea moriana o ntšoa 'meleng ke liphio, 3,6% - o nang le mantle. Chelete e setseng e hlahisoa e le metabolites e sa sebetseng, haholo ka bile le makhopho. Clindamycin ha e hlahisoe ke hemodialysis le peritoneal dialysis.

Matšoao

Mafu a tšoaetsanoang le a tšoaetsanoang a bakoang ke libaktheria tsa anaerobic tse nang le bothata ba "cindamycin" kapa "sterycoccus spp", "Staphylococcus spp" le Pneumococcus spp. hammoho le li-serovars tsa mofuta oa "chlamydia trachomatis":

• tšoaetso ea pampiri ea phefumoloho e kaholimo ho kenyelletsa tonsillitis, pharyngitis, sinusitis,
• ho ruruha tsebe e bohareng, feberu e khubelu,
• tšoaetso ea ts'ebetso e tlase ea phefumoloho, ho kenyelletsa bronchitis, pneumonia, empyma ea pleura le lesapo la matšoafo,
• mafu a tšoaetsanoang a letlalo le lisele tse bonolo, ho kenyeletsa makhopho a sefahleho (acne), furunculosis, ts'oaetso ea mafura a kenang butle, impetigo, abscesses, maqeba a nang le tšoaetso, lits'ebetso tse ikhethang tse tšoaeang letlalong le linama tse bonolo tse bakoang ke likokoana-hloko tse amehang ka moriana ona, joalo ka erysipelas le paronychia (panaritium),
• mafu a tšoaetsanoang a masapo le manonyeletso, ho kenyelletsa osteomyelitis le ramatiki,
• mafu a tšoaetsanoang a gynecological, ho kenyelletsa endometritis, tšoaetso ea mafura a kenang ka botšehaling, tšoaetso ea lisele tse ka thoko tsa mpa, li-tubes tsa "fallopian" le li-ovary, salpingitis le mafu a tšoaetsanoang a litho tsa pelvic, hammoho le litlhare tse thibelang likokoana-hloko tse sebetsang khahlanong le likokoana-hloko tsa gram-negative aerobic (e.g. glamicin),
• monotherapy ea tšoaetso ea lets'ollo e bakoang ke Chlamydia trachomatis,
• mafu a tšoaetsanoang a litho tsa ka mpeng, ho kenyelletsa le peritonitis le makhopho a ka mpeng (hammoho le lithethefatsi tse ling tse thibelang libaktheria tse sebetsang ka libaktheria tsa gram-negative aerobic),
• septicemia le endocarditis,
• tšoaetso ea lesapo la mokokotlo, joalo ka periodontal abscess le periodontitis,
• toxoplasma encephalitis ho bakuli ba AIDS (hammoho le pyrimethamine ho bakuli ba sa mameleng kalafo e tloaelehileng),
• Pneumocystis pneumonia ho bakuli ba AIDS (hammoho le primaquine ho bakuli ba hlokang mamello kapa ba hanyetsanang le kalafo e tloaelehileng),
• mala, incl. e bakoa ke li-multusistant Plasmodium falciparum, ka bobeli ka mokhoa oa monotherapy, hape hammoho le quinine kapa chloroquine,
• thibelo ea endocarditis ho bakuli ba nang le kutloisiso e eketsehileng ea penicillin,
• bacteric vaginosis.

Lokolla liforomo

Lipilisi tsa 150 mg le 300 mg (ka linako tse ling ka phoso li bitsoa matlapa).

Li-supplementories tsa vaginal 100 mg No. 3.

Gel bakeng sa ts'ebeliso ea kantle 1% (Dalacin T).

Vaginal cream 3% (ka linako tse ling e bitsoa mafura ka phoso.

Tharollo bakeng sa tsamaiso ea methapo le methapo ea methapo (Dalacin Ts phosphate) (liente ka ampoules ea ente).

Litaelo tsa mokhoa oa ho sebelisoa le oa litekanyetso

Bakeng sa ho qoba mathata, sebelisa ka tieo joalo ka ha u laetsoe ke ngaka.

Batho ba baholo: 600-1800 mg / letsatsi ka molomo ho litekanyetso tse 2, 3 kapa 4 (tekanyetso e lekanang).

Bana: 8-25 mg / kg boima ba mmele / letsatsi ka molomo ho litekanyetso tse 3-4 (tekanyetso e lekanang).

Bakeng sa ho qoba ho halefisoa ha esophagus, likhapha li lokela ho nooa ka khalase e tletse metsi.

Haeba tekanyo e lekantsoeng e le lethal dose le le leng le tlase ho feta se kahare ho Clindamycin ka har'a khase kapa ho na le mathata a ho koenya, ho lokela ho khothaletsoa mefuta ea lithethefatsi tsa botsoali.

Tšoaetso e bakoang ke beta-hemolytic streptococcus: litekanyetso li bontšitsoe kaholimo, kalafo e lokela ho tsoelapele bonyane matsatsi a 10.

Mafu a tšoaetsanoang le a tšoaetsanoang a litho tsa pelvic: 900 mg iv clindamycin lihora tse ling le tse ling tse 8 + iv ente e loketseng antibacterial e sebetsang khahlanong le likokoana-hloko tsa gram-negative aerobic (mohlala, glamicin ka tekanyo ea 2.0 mg / kg e lateloang ke 1.5 mg / kg lihora tse ling le tse ling tse 8 bakeng sa bakuli ba nang le ts'ebetso e tloaelehileng ea renal), bonyane matsatsi a 4, mme kamora hore boemo ba mokuli bo ntlafale, bonyane lihora tse 48. Ebe ba fetohela ho ho nka clindamycin kahare ka 450-600 mg ka lihora tse 6 letsatsi le leng le le leng. Tsela e felletseng ea kalafo ke matsatsi a 10-14.

Chlamydia trachomatis ts'oaetso ea cervix uteri: 450-600 mg ka molomo makhetlo a 4 ka letsatsi letsatsi le letsatsi bakeng sa matsatsi a 10-14.

Toxoplasmosis encephalitis ho bakuli ba AIDS: ho bakuli ba sa mameleng kalafo e tloaelehileng, clindamycin e sebelisoa hammoho le pyrimethamine ho latela moralo o latelang: 600-1200 mg ka molomo ka lihora tse ling le tse ling tse 6 bakeng sa libeke tse 2, ebe 300-600 mg ka molomo ka lihora tse ling le tse ling tse 6. Pyrimethamine e laetsoe ka tekanyetso ea 25 -75 mg ka molomo letsatsi le letsatsi. Ka tloaelo, nako ea phekolo ke libeke tse 8-10. Ha u sebelisa litekanyetso tse phahameng tsa pyrimethamine, acid ea folic e lokela ho fuoa lethal dose ea 10-20 mg / ka letsatsi.

Pneumocystis pneumonia ho bakuli ba nang le AIDS: 300-450 mg ka molomo ka lihora tse ling le tse ling tse 6 bakeng sa matsatsi a 21 le primaquine 15-30 mg ka molomo hang ka letsatsi ka matsatsi a 21.

Acill streptococcal tonsillitis / pharyngitis: makhetlo a 300 mg ka molomo habeli ka letsatsi matsatsi a 10.

Malaria: 10-20 mg / kg / letsatsi ka molomo ho batho ba baholo le 10 mg / kg / letsatsi bakeng sa bana lihora tse ling le tse ling tse 12 ka tekanyetso e lekanang bakeng sa matsatsi a 7 e le monotherapy, kapa hammoho le quinine (12 mg / kg nako le nako lihora tse 12) kapa chloroquine (15-25 mg ka mong lihora tse 24) ka matsatsi a 3-5.

Thibelo ea endocarditis ho bakuli ba nang le kutloisiso e eketsehang ea penicillin: li-600 mg ka molomo ho batho ba baholo le 20 mg / kg bakeng sa bana hora e le 'ngoe pele ho ts'ebetso e nyane ea ho buuoa kapa ea meno kapa ts'ebetso efe kapa efe e amanang le kotsi ea endocarditis.

Bakuli ba tsofetseng: ha ho na tlhoko ea ho fetola tekanyetso ka tloaelehileng (bakeng sa lilemo tse itseng) ts'ebetso ea sebete le a liphio.

Ka ntle. Karolo e tšesaane ea gel e kenngoa sebakeng se amehang sa letlalo le omileng le hloekileng makhetlo a 2 ka letsatsi. Ho fumana sephetho se khotsofatsang, kalafo e lokela ho tsoelapele libeke tse 6, 'me haeba ho hlokahala, u ka tsoella ho fihla ho likhoeli tse 6.

Tekanyetso e le 'ngoe (1 kopo e felletseng (5 g ea tranelate, e ka bang 100 mg ea clindamycin) e kenngoa ka hara mpa, ka ho khetheha nakong ea ho robala, ka matsatsi a 3 kapa a 7 a latellanang.

Ka paketeng e nang le 20 g ea tranelate ho na le likopo tsa 3 tsa polasetiki, mme ka sephutheloaneng se nang le 40 g ho na le likopo tse 7 tse etselitsoeng kenyelletso e nepahetseng ea tranelate ka hara mpa.

Melao ea ho sebelisa lithethefatsi

1. Tlosa cap, ea tube ea tranelate. Tšela mokopitsi oa polasetiki molaleng o tlotsitsoeng oa tube.
2. Ha o phunyelletsa phaephe ho tloha pheletsong e ka lehlakoreng le leng, ka bonolo senya tranelate ho mokopi. Mokopi o tletse ha piston ea hae e fihla setopong.
3. Koolla mokopi mokopanong ebe u thatela sekoaelo.
4. Ha u ntse u robetse mokokotlong, hula mangole a hao sefubeng.
5. Ho ts'oara mokopi ka mokhoa o nepahetseng, e kenye ka hloko ka hara botshehadi ka botebo kamoo o ka khonang, ntle le ho baka maikutlo a sa thabiseng.
6. Butle-butle o sutumetsa piston ho fihlela a tšela tranelate ka hara mpa.
7. Tlosa kopo ka hloko ka hara botshehadi 'me u e lahle.

Litla-morao

• bohloko ba ka mpeng
• ho nyekeloa, ho hlatsa,
• lets'ollo
• esophagitis
• sesophageal ulcer
• pseudomembranous colitis,
• dysbiosis,
• maculopapular rash,
• urticaria
• ho hlohlona
• ka tloaelo makhopho a bobebe ho isa tekanyong e matla,
• erythema multiforme,
• dermatitis e 'ngoe e tsoang ka morao-rao
• chefo e ka fokolisang
• anaphylactoid reaction
• linyeoe tsa neutropenia (leukopenia) le eosinophilia tsa tlhaho tse fetang li ile tsa hlokomeloa,
• vaginitis
• nts'etsopele ea bonohe.

Contraindication

• hypersensitivity ho clindamycin, lincomycin kapa motsoako ofe kapa ofe oa lithethefatsi.

Bokhachane le pelehi

Clindamycin o tšela placenta. Kamora ho hlahisoa ha litekanyetso tse 'maloa tsa moriana, khatello ea mokelikeli oa amniotic e ne e batla e le 30% ea khatello ea mali maling a mme. Clindamycin e lokela ho sebelisoa ho basali ba bakhachane ha feela phaello e reriloeng ho mme e pepesa kotsi e ka bang teng ho lesea. Clindamycin e fumanoa lebese la matsoele nakong ea motsoako oa 0,7-3.8 μg / ml.

Haeba ho hlokahala, nako ea ho beleha nakong ea kemaro e lokela ho emisa ho anyesa.

Litaelo tse khethehileng

Tabeng ea tšoaetso ea popelo e bakoang ke Chlamydia trachomatis, clindamycin monotherapy e sebetsa bakeng sa pheko e felletseng.

Litaba tsa pseudomembranous colitis ea ho teba ho fapaneng le ho sokelang bophelo li ile tsa bonoa ka ts'ebeliso ea hoo e batlang e le li-antibacterial tsohle, ho kenyeletsoa Dalacin, ka hona, maemong ohle a lets'ollo kamora ho sebelisa litlhare tsa antibacterial, monyetla oa tlhahlobo ena o lokela ho nahanoa. Lithethefatsi tsa antibacteria li hatella limela tse tloaelehileng tsa mala, tse ka tlatsetsang ho eketseheng ha Clostridia. Ho netefalitsoe hore chefo e hlahisoang ke Clostridiumntyile ke sesosa se ka sehloohong sa colitis e amanang le kalafo ea lithibela-mafu. Pseudomembranous colitis e ka ba teng ka bobeli ha ho nkuoa clindamycin, 'me libeke tse 2-3 kamora ho emisa kalafo, e bontšoa ke lets'ollo, leukocytosis, feberu, bohloko ba ka mpeng (ka linako tse ling e tsamaisana le excretion ka mali a fecal le mucus). Kamora ho fumanoa ha lefu la pseudomembranous colitis le fumaneha maemong a bonolo, kalafo le ts'ebeliso ea li-ion exchange resins (colestyramine, colestipol) li lekane ho hlakola, maemong a ho leka-lekana le maemong a boima, puseletso bakeng sa tahlehelo ea mokelikeli, li-electrolyte le protheine, ho ts'oaroa ha moriana o thibelang likokoana-hloko o sebetsang hantle khahlanong le Clostridiumcine, for example vancomycin ka tekanyetso ea 125-500 mg, kapa bacitracin ka tekanyetso ea 25 000 IU kahare makhetlo a 4 ka letsatsi bakeng sa matsatsi a 7-10, kapa metronidazole 250-500 mg makhetlo a 3 ka letsatsi. Lithethefatsi tse fokotsang mohopolo oa gastrointestinal motility ha lia lokela ho fanoa ka nako e ts'oanang le clindamycin.

Ha o sebelisa li-antibacterial agents tsohle, ho kenyelletsa le clindamycin, kholo e feteletseng ea likokoana-hloko tse sa tsotelleng moriana ona, haholo-holo li-fungus tse kang tomoso, lia khonahala. Ka kholiso ea bonohe, mehato e nepahetseng e lokela ho nkuoa ho latela maemo a bophelo.

Clindamycin ha ea lokela ho laeloa bakeng sa kalafo ea meningitis, kaha e kenella hampe ka har'a mokoallo oa mali (BBB).

Ha u fana ka moriana o noang litekanyetso tse phahameng, hoa hlokahala ho laola khatello ea kelello ea "clindamycin" ka plasma. Haeba kalafo e etsoa ka nako e telele, liteko tsa ts'ebetso ea sebete le tsa liphio li lokela ho etsoa khafetsa.

Bakeng sa bakuli ba nang le ts'oaetso ea sefuba le liphio, ha ho na tlhoko ea ho fetola tekanyetso ea moriana, hobane clindamycin ha e bokellane 'meleng haeba moriana o nooa ka molomo ka nako ea lihora tse 8.

Ho sebelisana le lithethefatsi

Ho thehiloe hore in vitro antagonism pakeng tsa dalacin le erythromycin e bonahala. Kaha mohanyetsi ona a kanna a bohlokoa ka tliliniki, meriana ena ha ea lokela ho nooa ka nako e le ngoe. Ho na le bopaki ba tšebelisano e tšoanang le chloramphenicol.

Ho fumanoe hore Dalacin e sitisa phetisetso ea methapo 'me, ka hona, e ka ntlafatsa phello ea lingoloa tse ling tsa mesifa ea ketso ea pherekano, ka lebaka leo, lithethefatsi li lokela ho sebelisoa ka hloko ho bakuli ba fumanang lithethefatsi tsa sehlopha sena.

Tšebeliso e tšoanang ea li-analgesics tsa opioid (narcotic), tse nang le tšusumetso e bohareng ea ts'ebetso ea phefumoloho, li ka lebisa ho tepelletseng maikutlong a ho phefumoloha ho fihlela apnea.

Tsamaiso e ts'oanang ka lithethefatsi tse felisang lefu la sethoathoa e eketsang kotsi ea pseudomembranous colitis.

Aminoglycosides e ntlafatsa bongata ba liketsahalo tsa antimicrobial tsa clindamycin.

Analogs ea lithethefatsi Dalacin

Analogue ea sebopeho sa ntho e sebetsang:

• Dalacin C phosphate,
• Zerkalin
• Klimitsin,
• Clindamycin,
• Klindatop,
• Klindafer
• Clindacin
• Klines,
• Klindovit.

Matšoao a ho sebelisoa

Tšoaetso ea baktheria e bakoang ke likokoana-hloko tse otlang pelo: ts'oaetso ea litho tsa ENT (ho kenyelletsa le tonsillitis, pharyngitis, sinusitis, otitis media), tšoaetso ea phefumoloho (bronchitis, pneumonia, abscess ea matšoafo, pleural empyema, fibrosing alveolitis), ts'oaetso ea masapo le manonyeletso ( osteomyelitis, ramatiki ea septic), tšoaetso ea letlalo le masapo a bonolo (ho kenyeletsa makhopho, makhopho, phlegmon, impetigo, panaritium, maqeba a nang le tšoaetso, abscesses, erysipelas), sepsis (haholo-holo anaerobic), tšoaetso ea pelvic le tšoaetso ea intraperitoneal ( ho kenyelletsaperitonitis, abscesses ea litho tsa ka mpeng le ts'ebeliso e ts'oanang ea lithethefatsi tse sebetsanang le likokoana-hloko tse mpe tsa gram-negative aerobic), mafu a gynecological (endometritis, adnexitis, colpitis, abscesses ea fallopian tubes le mae a bomme, salpingitis, pelvic peritonitis), ts'oaetso ea cavity ea molomo abscess), toxoplasma encephalitis, mala (e bakoang ke Plasmodium falciparum), pneumonia (e bakoang ke Pneumocystis carinii), sepsis, endocarditis, chlamydia, feberu e khubelu, diphtheria.

Foromo ea litekanyetso

Lipilisi tsa 150 mg, 300 mg

Ho latela sekhukhu se le seng:

ntho e sebetsang - clindamycin hydrochloride 177,515 mg kapa 355.030 mg (e lekanang le clindamycin 150 mg kapa 300 mg),

Baeti: magnesium e tšehali, starch ea poone, talc, lactose monohydrate,

capsule shell titanium dioxide (E 171), gelatin.

Li-capsules tsa "solatin opaque" tsa "solatin" tse nang le sekwahelo le 'mele o mosoeu, enke e ntšo e hatisitsoeng "Pfizer" le khoutu "Clin 150". Likahare tsa likhase ke phofo e tšoeu (bakeng sa litekanyetso tsa 150 mg).

Li-capsules tsa "gelatin" tse tiileng tse nang le selikalikoe le 'mele o mosoeu, enke e ntšo e hatisitsoeng "Pfizer" le khoutu "Clin 300". Likateng tsa li-capsules ke phofo e tšoeu (bakeng sa litekanyetso tsa 300 mg).

Melemo ea pharmacological

Mofumahali

Kamora ho tsamaisoa ka molomo, clindamycin e potlakile ebile e batla e kenella ka botlalo (90% ea lethal dose e nkuoeng).

Ho ja ka nako e le 'ngoe ha ho ame tšilafalo ea lithethefatsi maling a mali.

Likhakanyo tsa Serum

Ho batho ba baholo ba phetseng hantle, ho tsepamisa mohopolo oa plasma ho ka ba ka bang 2-3 mg / L mme ho bonoa hora e le 'ngoe ka mor'a ho tsamaisoa ka molomo ka 150 mg ea clindamycin hydrochloride kapa 4-5 mg / L kamora tsamaiso ea molomo ea 300 mg. Ebe, mahloriso a plasma a theoha butle, a saletse ka holimo ho 1 mg / L bakeng sa lihora tse fetang 6. Ts'oarello ea plasma e eketseha ka tatellano ho latela keketseho ea tekanyetso e nkuoeng. Ho tsepamisa maikutlo ho serum ho tlalehoa ho fokola hanyane ho bakuli ba nang le lefu la tsoekere ho feta ho bakuli ba phetseng hantle. Nako e akaretsang ea bophelo ba "bi" Clindamycin e tsoang serum ke lihora tse 2,5.

Ho Kopanya Liprotheine tsa Plasma

Ho kopanya liprotheine tsa plasma ho tloha ho 80 ho ea ho 94%.

Ho potoloha ha lisele le maro a 'mele

Clindamycin e ajoa ka bongata libakeng tse phahameng haholo mohloling oa metsi a tsoang kantle ho lisele le liseleng. Ho kenella ka har'a mokelikeli oa "cerebrospinal" haholo.

Clindamycin e tšeloa ka har'a sebete.

Hoo e ka bang 10% ea moriana o ntseng o sebetsa o tšeloe ka har'a moroto 'me 3.6% e hloekisoa mantle. Tse setseng li hlahisoa joalo ka metabolites e sa sebetseng.

Ho tsepamisa maikutlo ha Serum clindamycin ha ho fetohe ka lebaka la hemodialysis kapa peritoneal dialysis.

Mofumahali

Meeli e latelang ea sensitivity ea bonyane ba inhibitory concentration (MIC) e sebelisoa ho khetholla liphoofotsoana tse sa bonahaleng, likokoana-hloko tse nang le ts'oaetso e bohareng, le lintho tse phelang tse nang le ts'oaetso e lipakeng tsa lintho tse sa sebetseng:

S ≤ 2 mg / L le R> 2 mg / L.

Ho ata ha khatello e fumanoeng ho ka fapana bakeng sa mefuta e itseng ho latela sebaka sa tikoloho le nako, mme ho lakatseha ho ba le tlhaiso-leseling mabapi le litšobotsi tsa tikoloho tsa ho ata ha khanyetso, haholo kalafo ea ts'oaetso e matla. Tlhahisoleseling ena e fana ka mohopolo feela oa hore ho ka ba le monyetla oa hore lintho tse ling li hlasele moriana o thibelang likokoana-hloko tsena.

Gram e ntle cocci, ho kenyelletsa:

-Streptococcus eseng karolo efe kapa efe ea lihlopha

'Nete ea likharetene tse senang maikutlo, e kenyelletsa:

Gram hampeaerobicbaktheria

-E seng mafuragram hampebacilli

Clindamycin e bonts'a tšebetso in vitro le ho vivo khahlano Toxoplasma gondii.

* Ho ata ha methapo ea methicillin ke hoo e ka bang 30 ho isa ho 50% bakeng sa staphylococci kaofela mme e shejoa haholo maemong a sepetlele.

Tekanyetso le tsamaiso

Setlhare sena se sebelisoa kahare, e le ho qoba ho koeneha ha 'metso, likhakeletsi li lokela ho hlatsuoa ka khalase e felletseng ea metsi (250 ml).

Tekanyetso e tloaelehileng ea letsatsi le letsatsi ke 600-1800 mg / ka letsatsi, e arotsoe ka tekanyetso ea 2, 3 kapa 4. Tekanyo e phahameng ea letsatsi le letsatsi ke 2400 mg.

Bakuli ba bana

Tekanyo ea 8-25-25 mg / kg ka letsatsi, e arotsoe ka tekanyetso e 3 kapa 4 e lekanang.

Ts'ebeliso ho bana e bontšoa ha ba ka koenya koaelo eohle.

Bakuli ba baholo

Boithuto ba Pharmacokinetic kamora ho tsamaisoa ka molomo kapa kahare ho clindamycin ha boa ka ba senola liphapang tsa bohlokoa lipakeng tsa bakuli ba banyenyane le ba tsofetseng ba nang le ts'ebetso e tloaelehileng ea sebete le ho tloaeleha (ho nahanoa ka lilemo tsa ts'ebetso ea renal. Ntlheng ena, phetoho ea tekanyetso ho bakuli ba tsofetseng ba nang le ts'ebetso e tloaelehileng ea sebete le e tloaelehileng (ho nahanela lilemo tsa ts'ebetso) ts'ebetso ea ho hlaphoheloa ha liphio ha e ea hlokahala.

Bakuli ba nang le ts'oaetso ea renal e senyehileng

Bakeng sa bakuli ba nang le ho fokola ha renal, ho lokisoa ha lethalamo la clindamycin ha ho hlokahale.

Bakuli ba nang le ts'ebetso ea sebete e sa sebetseng

Bakeng sa bakuli ba nang le ho fokola ha hepatic, ho lokisoa ha lethalamo la clindamycin ha ho hlokahale.

Tekanyetso ea matšoao a khethehileng

Kalafo ea tšoaetso ea Beta Hemolytic Streptococcus

Litlhahiso tsa tekanyetso li tsamaellana le litekanyetso tse kaholimo ho batho ba baholo le bana. Phekolo e lokela ho tsoelapele bonyane matsatsi a 10.

Phekolo ea asillarycoccal tonsillitis kapa pharyngitis e hlobaetsang

Motsoako o khothalelitsoeng ke 300 mg habeli ka letsatsi bakeng sa matsatsi a 10.

Pheko ea kalafo ea mafu a ho ruruha ea litho tsa kahare

Phekolo e lokela ho qala ka tharollo ea methapo Dalacin C Phosphate (ka tekanyetso ea 900 mg ka nako e 'ngoe le e' ngoe ka lihora tse 8 tse kopantsoeng le motsoako o thibelang mafu o nang le pono e nepahetseng ea ts'ebetso khahlano le likokoana-hloko tsa gram-negative aerobic, ho etsa mohlala, ka glamicin ka tekanyo ea 2.0 mg / kg, e lateloe ke lethal dose ea 1.5 mg / kg nako le nako ho lihora tse 8 ho bakuli ba nang le ts'ebetso e tloaelehileng ea renal. Tsamaiso e kenelletseng ea lithethefatsi e lokela ho ntšetsoa pele bonyane matsatsi a 4 le bonyane lihora tse 48 kamora hore boemo ba mokuli bo ntlafale.

Kamora moo, o lokela ho tsoelapele ho nka Dalacin® ka molomo ka tekanyetso ea 450-600 mg ka nako e 'ngoe le e' ngoe lihora tse 6 letsatsi le leng le le leng ho fihlela pheletso ea kalafo ka nako eohle ea matsatsi a 10-14.

Masapo le tšoaetso e kopaneng

Motsoako o khothalelitsoeng ke 7.5 mg / kg ka lihora tse ling le tse ling tse 6.

Thibelo ea endocarditis ho bakuli ba nang le kutloisiso ea penicillin

Bakeng sa bakuli ba baholo, lethal dose le khothalletsoang ke 600 mg 1 hora pele ho ts'ebetso; bana: 20 mg / kg hora e le 1 pele ho ts'ebetso.

Sokolla foromo le sebopeho

Dalacin e fumaneha ka mefuta e latelang ea litekanyetso:

• Gel bakeng sa ts'ebeliso ea kantle ho 1%: e pepeneneng, e se nang 'mala, viscous (30 g e ngoe le e ngoe ka lishubeng, 1 tube ho mokotla oa karete).
• Vaginal cream 2%: e tšoeu (20 kapa 40 g, e 'ngoe le e' ngoe ka meqolong ea polyethylene kapa foil ea aluminium e felletseng ka bafani ba 3 kapa 7 (ka ho latellana), e behiloeng ka lebokoseng la karete.
• Li-capsule: li-gelatinous, li thata, li na le 'mele le sekoaelo se sesoeu, tse ngotsoeng "P&U 225" (150 mg ka' ngoe) kapa "P&U 395" (300 mg ka 'ngoe), litaba tse ka har'a likhasetso ke phofo e tšoeu (8 kapa 10 likhomphutha. 2 kapa lillo tse 10 ka lebokoseng la lebokose la karete),
• Li-suppositories tsa Vaginal: sebopeho sa torpedo, se tiileng, se nang le sebaka se boreleli, se batlang se soeufala kapa se tšoeu (li-pcs tse 3. Ka maratsoana a foil e nang le kapa ka ntle le mokopi, sekala se le seng ka mokotleng oa karete.

Sebopeho sa li-300 mg tsa gel bakeng sa ts'ebeliso ea kantle:

• Lintho tse sebetsang: clindamycin (ka sebopeho sa phosphate) - 10 mg,
• Likarolo tse thusang: methyl paraben - 3 mg, allantoin - 2 mg, polyethylene glycol - 100 mg, propylene glycol - 50 mg, carbomer 934P - 7.5 mg, tharollo ea 40% sodium hydroxide - ka bongata bo lekaneng, metsi a hloekisitsoeng - ka bongata bo lekaneng ho fihla ho 1000 mg .

Sebopeho sa tranelate ea basali ea 1000 mg:

• Lintho tse sebetsang: clindamycin (ka sebopeho sa phosphate) - 20 mg,
• Likarolo tse thusang: cetyl Palmitate - 32.1 mg, phofo ea stearic - 21.4 mg, polysorbate 60 - 50 mg, sorbitan monstearate - 20 mg, propylene glycol - 50 mg, joala ba benzyl - 10 mg, joala ba cetstearyl - 32.1 mg, liminerale. oli - 64.2 mg, metsi a hloekisitsoeng - ka bongata bo lekaneng.

Moqomo oa 1

• Lintho tse sebetsang: clindamycin (ka sebopeho sa hydrochloride) - 150 kapa 300 mg,
• Likarolo tse thusang: talc, lactose, starch ea poone, stearate ea magnesium, gelatin, titanium dioxide.

Karolo ea 1 ea tlatsetso ea botšehali:

• Lintho tse sebetsang: clindamycin (ka sebopeho sa phosphate) - 100 mg,
• Likarolo tse thusang: mafura a tiileng (Witepsol H-32, motsoako oa monoglycerides, diglycerides le triglycerides) - hoo e ka bang 2400 mg.

Contraindication

Dalacin e kopantsoe le boteng ba hypersensitivity ho clindamycin, lincomycin kapa likarolo tse thusang tsa litlhare.

Lithethefatsi tse ka har'a li-capsules li lokela ho nkuoa ka hloko ho bakuli ba nang le mafu a gastrointestinal (nalane), haholo-holo ka ulcerative colitis, myasthenia gravis (mohlomong e sitisitse phetiso ea methapo ea methapo), ho hloleha ho matla ha sebete.

Ntle le moo, Dalacin ka mefuta e meng ea litekanyetso li kopantsoe ho mafu a latelang:

• Nalane ea colitis e amanang le lithibela-mafu,
• Lilemo: ho fihlela lilemo tse 18 bakeng sa tranelate ea mosali le litlatsetso, ho fihlela lilemo tse 12 bakeng sa gel bakeng sa tšebeliso ea kantle (ha ho na datha mabapi le katleho le polokeho ea Dalacin sehlopheng sena sa bakuli),
• Hypersensitivity ho lincomycin kapa clindamycin ho anamnesis (bakeng sa gel bakeng sa ts'ebeliso ea kantle).

Tekanyetso le tsamaiso

Dalacin ka mokhoa oa likhabapo e nkuoa ka molomo. Bakeng sa ho qoba mathata, ho kgothaletswa ho e sebelisa ka mokhoa o boletsoeng ke ngaka.

Ho qoba ho halefisoa ha membrane ea mucous ea esophagus, li-capsules li lokela ho nooa ka khalase e felletseng ea metsi.

Hangata moriana o nooa:

• Batho ba baholo: 600-1800 mg ka letsatsi, khafetsa ea tsamaiso - makhetlo a 2-4 (ka tekanyetso e lekanang),
• Bana: 8-25 mg / kg ya boima ba mmele ka letsatsi, khafetsa ea tsamaiso ke makhetlo a 3-4 (ka tekanyetso e lekanang).

Molemong oa kalafo ea tšoaetso e bakoang ke beta-hemolytic streptococcus, Dalacin e sebelisoa ho litekanyetso tse boletsoeng ka holimo. Nako ea thuto ea phekolo ke bonyane matsatsi a 10.

Phekolo ea mafu a tšoaetsanoang le a tšoaetsanoang ea litho tsa pelvic e qala ka tsamaiso ea methapo ea methapo ea methapo, ka tekanyo ea 900 mg ka mor'a lihora tse 8, ka nako e ts'oanang le moemeli ea loketseng oa antibacterial bonyane matsatsi a 4. Kamora hore boemo ba mokuli bo ntlafale, kalafo e ntse e tsoela pele bonyane matsatsi a mang a mabeli, kamora moo Dalacin e beoa ka sebopeho sa likhabapo ka tekanyetso e le 'ngoe ea 450-600 mg. Moriana o nooa letsatsi le leng le le leng ka mor'a lihora tse tšeletseng. Tsela e felletseng ea kalafo ke matsatsi a 10-14.

Ho latela bopaki, Dalacin o ngotsoe:

• Toxoplasmosis encephalitis ho bakuli ba AIDS: maemong a ho se mamelle kalafo e tloaelehileng, sethethefatsi se nooa ka mokhoa o ts'oanang le pyrimethamine ho latela moralo o latelang: Dalacin - 600-1200 mg ka nako e ngoe le e 'ngoe lihora tse 6 ka matsatsi a 14, ebe 300-600 mg ka makhetlo a mangata a ts'ebeliso, pyrimethamine - letsatsi le letsatsi 25 -75 mg. Joaloka molao, thupelo ea phekolo ke libeke tse 8-10. Ha u sebelisa pyrimethamine ka tekanyetso e phahameng, 10-20 mg ea folic acid ka letsatsi e lokela ho fuoa,
• Ts'oaetso ea Cervical e bakoang ke Chlamydia trachomatis: 450-600 mg ka letsatsi, tekanyetso makhetlo a 4 ka letsatsi, nako ea kalafo matsatsi a 10-14,
• Acute streptococcal pharyngitis / tonsillitis: matsatsi a 10, makhetlo a 300 mg makhetlo a 2 ka letsatsi,
• Pneumocystis pneumonia ho bakuli ba AIDS: ka matsatsi a 21, 300-450 mg mong le e mong lihora tse 6 ka nako e le ngoe le primaquine, 15-30 mg hang ka letsatsi,
• Malaria: batho ba baholo - 10-20 mg / kg ka letsatsi, bana - 10 mg / kg ka letsatsi. Moriana o nooa ka tekanyetso e lekanang le lihora tse ling le tse ling tse 12, bolelele ba matsatsi a 7. Hape hoa khoneha ho sebelisa Dalacin ka nako e le ngoe le quinine (lihora tse ling le tse ling tse 12 ho 12 mg / kg) kapa chloroquine (lihora tse ling le tse ling tse 24 ho 15-25 mg), nako ea thupelo ke matsatsi a 3-5.

Bakeng sa thibelo ea endocarditis ho bakuli ba nang le hypersensitivity ho penicillins, ho fanoa ka Dalacin: ho batho ba baholo - 600 mg, bakeng sa bana - 20 mg / kg. Moriana o lokela ho nooa hora e le 'ngoe pele ho kenella meno kapa ho buuoa ka mokhoa o mong, kapa ts'ebetso efe kapa efe eo ho nang le kotsi ea ho ba le endocarditis.

Bakuli ba tsofetseng ba nang le ts'ebetso e tloaelehileng ea renal le hepatic bakeng sa lilemo tse itseng, hammoho le bakuli ba nang le mathata a sebetsang a sebete le liphio, ha baa lokela ho fetola tekanyetso.

Ka kalafo ea bacteric vaginosis, hangata e fanoa:

• C cream ea Vaginal: 5000 mg ea tranelate (1 kopo e felletseng, e ka bang 100 mg ea clindamycin) e lokela ho kenngoa ka hara mpa. Mokhoa o etsoa hantle pele o robala. Nako ea thuto - matsatsi a 3 kapa a 7,
• Li-supplement tsa Vaginal: supplementory e le 'ngoe e fanoa ka nako e le' ngoe ka letsatsi, ka ho khetheha pele ho robala. Thupelo e nka matsatsi a 3.

Dalacin ka sebopeho sa gel e sebelisoa kantle ho kalafo ea makhopho a sefahleho. Setlhare sena se kenngoa ka mpeng e tšesaane sebakeng se amehang (letlalo le omeletseng, le hloekileng). Ho sebelisoa hangata - makhetlo a 2 ka letsatsi. Nako ea thupelo e khothalelitsoeng ke libeke tse 6-8. Ho ea ka lipontšo, ts'ebeliso ea Dalacin e ka khonahala bakeng sa likhoeli tse 6. Haeba, kamora ho sebelisa gel ka likhoeli tse 'maloa, katleho ea kalafo e fokotseha, khefu e hlokahala bakeng sa libeke tse 4.

Litlamorao

Ha o sebelisa Dalacin kahare, litlamorao tse latelang li ka hlaha:

• Sistimi ea tšilo ea lijo: ho nyekeloa ke pelo, bohloko ba ka mpeng, esophagitis, lets'ollo le ho hlatsa, pseudomembranous colitis, sesophageal ulcer, jaundice, dysbiosis, ho hlohlona ha sebete, ho kenyeletsa hyperbilirubinemia,
• Hematopoiesis (hematopoietic system): linyeoe tsa eosinophilia ea tlhaho e fetang le leukopenia (neutropenia), hammoho le linyeoe tsa thrombocytopenia le agranulocytosis, leha ho le joalo, ha ho na kamano pakeng tsa tsamaiso ea Dalacin le liketsahalo tsena.
• Litla-morao: lintho tse ka tloaelo ho etsahala hangata ha motho a le lekhopho le lekaneng ebile a le bobebe, hangata - a lemetse ka hohlehoho, a bile a le makhopho a tsoang pepeneng, erythema multiforme, anaphylactoid reaction,
• Tse ling: vaginitis.

Hape nakong ea kalafo, ho ka hlaha litla-morao tse latelang: nts'etsopele ea matla a ho se sebetse hantle, phetisetso ea methapo ea methapo.

Ha o phekola vaginosis ea baktheria le Dalacin ka mokhoa oa tranelate ea bosali le li-supplement, ho ka etsahala hore ho be le likhathatso tse tsoang litsamaisong tse ling tsa 'mele:

• Sistimi ea ho ikatisa: vulvovaginitis, vagidi candidiasis, ho tsoa ka mpeng, ho teneha ha mucous membrane ea bosaling le botšehali, tšoaetso ea setho sa botšehali, trichomonias vaginitis, bohloko ba ka popelong, ho beleha ka tsela e sa tloaelehang, ho se sebetse ka ho ilela khoeli, ho senyeha ha litho tsa botšehali, endometriosis,
• Sistimi ea urinary: ts'oaetso ea pampitšana ea urinari, dysuria, proteinuria,
• Sistimi ea lijo: Lits'oaetso tsa ho ja: ho kheloha ha tatso, ho hlasimoloha, ho nyekeloa, lets'ollo, ho hlatsa, dyspepsia, ho sokela, halitosis, ts'oenyeho ea ka mpeng,
• Letlalo: erythema, pruritus, lekhopho, "candidiasis" ea letlalo, lekhopho la maculopapular, urticaria,
• Tsamaiso ea methapo e bohareng: ho tsekela, ho opeloa ke hlooho, vertigo,
• Sistimi ea endocrine: hyperthyroidism, glucosuria,
• Sistimi ea khatello ea maikutlo: Ts'oaetso ea pampiri e kaholimo ho marang-rang, nosebleeds,
• 'Mele ka kakaretso: ts'oaetso ea fungal, tšoaetso ea baktheria, bloating, bohloko ba lehae le / kapa bo akaretsang, bohloko bo ka tlase ba mpa, mahlaba a mpeng, ho kheloha hoa liphetho tsa tlhahlobo ea likokoana-hloko ho tsoa ho se tloaelehileng, bohloko ba morao, ho hlaseloa ke lintho tse kulang.
• Boitšoaro ba lehae: ho ruruha edema le ho hlohlona sebakeng sa ente.

Ha o sebelisa li-gel bakeng sa ts'ebeliso ea kantle, ho ka hlaha litlamorao tse latelang:

• Sistimi ea tšilo ea lijo: colitis, bohloko ba ka mpeng, pseudomembranous colitis, mathata a dyspeptic (ho nyekeloa ke pelo, lets'ollo, ho hlatsa),
• Mokhatlo oa pono: Maikutlo a tukang mahlong,
• Li-mahloko: hangata letlalo le omme, tlhahiso e eketsehileng ea litšoelesa tsa sebaceous, ho teneha letlalo, urticaria, dermatitis ea ho ikopanya,
• Tse ling: folliculitis e hlahisoang ke limela tse sa gram.

Litaelo tse khethehileng

Ka nts'etsopele ea letšollo ka mor'a ho etsa kopo ea Dalacin ka molomo kapa kahare, ho ka nahanoa hore monyetla oa ho ntšoa ke pseudomembranous colitis. Lefu lena le ka hlaha hape kamora libeke tse 2-3 kamora ho khaotsa kalafo. Matšoao a eona a ka sehloohong a kenyelletsa: lets'ollo, leukocytosis, feberu, bohloko ba ka mpeng (ka linako tse ling bo tsamaisana le secretion ea mucus le mali ka mantle). Haeba ho hlokahala, mehato ea ho hlahloba le ea kalafo e lokela ho nkuoa.Ka tšebeliso ea ka ntle ea lithethefatsi, linyeoe tsa colitis li fumaneha seoelo, leha ho le joalo, tlhokomelo e lokela ho nkuoa mme, haeba ho ts'oaroa ha lets'ollo le telele kapa le matla, ts'ebeliso ea gel e lokela ho emisoa.

Bakeng sa tšoaetso ea popelo e bakoang ke Chlamydia trachomatis, capsule monotherapy e nang le Dalacin e sebetsa bakeng sa pheko e felletseng.

Ha o kenya Dalacin kahare, kholo e kholo ea likokoana-hloko e sa tsotelleng moriana e ka etsahala, haholo-holo fungus e kang tomoso. Tabeng ea bonohe, ho latela maemo a kliniki, ho lokela ho nkuoa mehato e nepahetseng.

Clindamycin ha ea lokela ho laeloa bakeng sa kalafo ea meningitis.

Ha o laela Dalacin ka tekanyetso e phahameng, o hloka ho laola khatello ea maikutlo ea clindamycin ka plasma. Ka kalafo ea nako e telele, liteko tsa ts'ebetso ea liphio le sebete li lokela ho etsoa.

Likokoana-hloko tse latelang tse ka sebelisoang li lokela ho behelloa ka thoko pele ho fana ka taelo ea Dalacin bakeng sa kalafo ea vulvovaginitis: Chlamydia trachomatis, Trichomonas vaginalis, Candida albicans, Neisseria gonorrhoeae le Herpes simplex virus.

Re lokela ho hopola hore tšebeliso ea methapo ea lithethefatsi e ka baka kholo e kholo ea likokoana-hloko tse sa tsotelleng ketso ea eona, haholo-holo li-fungus tse kang tomoso.

Ka tšebeliso ea lithethefatsi tsa kahare, ho kopanela liphate ho lokela ho qojoa, hammoho le ts'ebeliso ea mefuta e meng ea lihlahisoa tse tsamaisoang kahare (mohlala, li-syringes, tampons).

Ts'ebeliso ea Dalacin ka mokhoa oa tranelate kapa supplementory nakong ea ho ea khoeling ha e khothalletsoe. Qaleho ea kalafo ntlheng ena e lokela ho chechisoa ho fihlela qetellong ea khoeli.

Dalacin e na le likarolo tse amang matla a lihlahisoa tsa rabara kapa tsa latex (taolo ea bokhachane ea botšehali, likhohlopo). Ts'ebeliso ea lihlahisoa tse joalo nakong ea kalafo le nakong ea matsatsi a 3 kamora ts'ebeliso ea lithethefatsi ha e khothalletsoe.

Qoba ho ikopanya le li-gel bakeng sa tšebeliso ea kantle ho li-membrane tsa mucous tsa molomo le mahlo. Kamora ho sebelisa moriana, hlatsoa matsoho a hau ka botlalo. Tabeng ea ho kopana ka phoso le libaka tse tebileng tsa sefahleho (li-abrasion letlalong, mahlo, mucous membrane), hlakola ka botlalo ka metsi a pholileng.

Ho sebelisana le lithethefatsi

Clindamycin ha ea lokela ho nkuoa ka molomo ka nako e le 'ngoe le erythromycin le chloramphenicol.

Ho na le ho hanyetsa ha likokoana-hloko ho lincomycin le clindamycin.

Clindamycin e lokela ho sebelisoa ka hloko ho bakuli ba fumanang libaka tse ling tsa ho phomotsa mesifa.

Ka tšebeliso e tšoanang ea Dalacin ka hare ka li-analio tsa opioid (narcotic) tse nang le ts'oaetso e bohareng ea ts'ebetso ea phefumoloho, nts'etsopele ea khatello ea maikutlo ea ho phefumoloha ho eketsehileng ho fihlela apnea e khonahala.

Monyetla oa ho ba le pseudomembranous colitis e eketseha ka tšebeliso e tšoanang ea Dalacin e nang le lithethefatsi tse felisang lefu le fokotsang mohopolo.

Ponahalo ea antimicrobial ea clindamycin e atolosoa ke aminoglycosides.

Tšebeliso e tšoanang ea tranelate ea basali le litlatsetso tse nang le lithethefatsi tse ling bakeng sa tsamaiso ea methapo ea kutlo ha e khothalletsoe.

Li-Analogs tsa Dalacin ke: Klindatsin, Klindes, Klindamitsin, Klindovit, Klindatop.

Capsules Dalacin C

Theko ea likhase - ho tloha 1324 p.

Li-capsules li na le talc, lactose le magnesium stearate e le likarolo tse thusang. Khetla e sebelisitse starch, titanium dioxide le gelatin.

Ea pele ke li-capsules. E ka ba boima ba 150 kapa 350 mg. Li-capsules li tiile, 'mala oa' mele le sekoaelo ke pherese kapa 'mala o mosoeu,' mala oa phofo o kahare o tšoeu.

Tharollo ea entetso

Litsenyehelo tsa Dalacin C ka mokhoa oa tharollo ea ente li tsoa ho 587 r ka ampoule e ngoe.

Tharollo ea liente, lintho tse ling ke metsi a ente, disodium edetate, benzyl joala.

Ampoules e kanna ea ba le tharollo ea 2, 4 kapa 6 ml. Mokelikeli ha o na 'mala. E fumaneha ka lijaneng tse entsoeng ka khalase e se nang 'mala ea sehlopha sa I.

Ho sebelisana le mekhoa e meng

Litaelo tsa moriana o re li ka ama li-pharmacokinetics tsa meriana e meng.

Kahoo, e khona ho ntlafatsa haholo phello ea boikhathollo ba mesifa 'meleng. Ka hona, ts'ebeliso ea lithethefatsi tsena e etsoa ka nako e ts'oanang tlasa taolo e tiileng ea ngaka. Litekanyetso tsa litlhare ka bobeli li fetoloa ka bonngoe.

Haeba u sebelisa lithethefatsi tse khahlanong le lets'ollo le Dalacin C ka nako e ts'oanang, kotsi ea colitis e eketseha.

Ho thibetsoe ka thata ho sebelisa sehlahisoa, litaelo tseo ho buisanoang ka tsona sehloohong sena, hammoho le calcium gluconate, barbiturates, erythromycin, aminophylline, ampicillin, le magnesium sulfate.

Litlamorao

Ha u sebelisa meriana ena, matšoao a mangata a sa thabiseng a ka hlaha.

Phekolo ka meriana ena e thibelang likokoana-hloko e ka baka:

• Bohloko ba ka mpeng
• Ho nyekeloa ke pelo le ho hlatsa
• Letšollo
• Esophagitis
• Dysbacteriosis
• Thrombocytopenia
• Leukopenia
• Agranulocytosis
• Eosinophilia
• Vaginitis
• Letlalo la letlalo, likokoana-hloko, le ho hlohlona
• Bofokoli ba 'mele
• Ho tsekela
• Apnea
• Khatello ea mali e phahameng

Ka tšebeliso ea nako e telele ea li-capsules, londa tsa esophageal li ka hlaha.

Maemong a sa tloaelehang, meriana e loantšang likokoana-hloko e ka tsosetsa chefo ea epidermal necrolysis.

Karabelo e kulang ea lithethefatsi e ka bonahala e le ho ts'oaroa ha anaphylactic.

O ka ithuta ho eketsehileng ka hore na o ka emisa lets'ollo joang sehloohong: ho loants'a lets'ollo.

Bongata

Nyeoe ea overdose ha ea ngolisoa.

Leha ho le joalo, haeba u sa latele litekanyetso, menyetla ea ho tsitsipana ea anaphylactic e eketseha haholo. Ho e felisa, ho sebelisoa meriana ea antihistamines le glucocorticoid hammoho le adrenaline. Katleho ea hemodialysis ha liketsahalo tsa anaphylactic e le zero. Ha ho na pheko e tobileng ea ntho e sebetsang ea Dalacin C

Lipehelo le maemo a polokelo

Taeo ea moriana e re o hloka ho e beha sebakeng se lefifi ka mongobo o tloaelehileng. Mocheso oa polokelo e ka ba likhato tse 15 ho isa ho 25 tsa Celsius.

Bophelo ba Shelf ka foromo ea capsule ke likhoeli tse 60.

Setlhare ka mokhoa oa tharollo ea liente li ka sebelisoa likhoeli tse 24 ho tloha ka letsatsi la tlhahiso.

Akrikhin OJSC (RF) kapa Pharmaprim LLC (Moldova)
Theko - ho tloha 207 r

Sesebelisoa se sebetsang se tšoana hantle le sethethefatsi seo ho buuoang ka sona. E fumaneha ka mokhoa oa li-supplement kapa li-cream tsa basali.

Melemo:

• E sebetsang haholoanyane bakeng sa vaginosis ea baktheria, kaha e sebelisoa ka mokhoa o holimo
• Cream ke mofuta o bonolo ho o sebelisa.

Chelete:

• Ts'ebeliso ea li-suppositories ha e loketse motho e mong le e mong
• Ha e fumanehe ka foromo ea letlapa.

Clindamycin

Nizhpharm (Serbia)
Theko - ho tloha 167 r

Sesebelisoa se sebetsang ke motsoako o tšoanang oa lik'hemik'hale. E fumaneha ka foromo ea capsule.

Melemo:

• Foromo ea litekanyetso (li-capsules) e loketse ho sebelisoa.
• Theko e tlase.

Chelete:

• E kopantsoe le moimana
• Litla-morao tse tšoanang le tsa Dalacin C.

Mokhoa oa ho sebelisa: litekanyetso le kalafo

Ka hare, batho ba baholo: li-mg ka tse ling le tse ling le tse ling le tse ling tse 150 ho tsoa ts'oaetso e matla. Bana: 8-25 mg / kg / letsatsi (ho latela boholo ba ts'oaetso), e arotsoe ka tekanyetso ea 3-4.

Ka kalafo ea colpitis e bakoang ke Chlamydia trachomatis, 450 mg e beoa linako tse 4 ka letsatsi bakeng sa matsatsi a 10-14.

Ho / m kapa ho / ho: ho batho ba baholo - 300 mg makhetlo a 2 ka letsatsi. Bakeng sa tšoaetso e itekanetseng - 150-300 mg makhetlo a 2-4 ka letsatsi, bakeng sa tšoaetso e matla - 1,2-2.7 g / letsatsi bakeng sa liente tsa 2-4. Ka tšoaetso e behang bophelo kotsing, lethalinyana la iv le ka eketsoa ho 4,8 g / ka letsatsi.

Bana ba fuoa 10-25 mg ea moriana / kg / letsatsi, e arotsoe ka litekanyetso tse tharo.

Bakeng sa tsamaiso ea iv, hlapolla mokokotlong o sa phahame ho 6 mg / ml, tharollo e hlapollotsoeng e kentsoe iv ho theoha ka metsotso e 10-60.

Lenaneo la ho theola le nako ea infusion: tekanyetso, bophahamo ba solvent le nako ea infusion (ka tatellano): 300 mg - 50 ml - 10 min, 600 mg - 100 ml - 20 min, 900 mg - 150 ml - 30 min, 1200 mg - 200 ml - Metsotso e 45 Ho kenyelletsa tlhahiso e fetang 1.2 g nakong ea hora ea 1 ea ts'ebetso ha e khothalletsoe.

Tharollo e sebelisoa nakong ea lihora tse 24 ho tloha ka letsatsi la ho itokisa. Ka kalafo ea colitis e bakoang ke Clostridiumntyile, hang-hang ho kopantsoe tsamaiso le vancomycin ka matsatsi a 10 ho 500 mg - 2 g ka letsatsi, e arotsoe ka tekanyetso e 3 kapa 4 e lekanang.

Bakuli ba nang le ramatiki e matla ea renal / hepatic ha ba hloka ho lokisoa.

Ketso ea pharmacological

Antibiotic ea sehlopha sa lincosamides. E na le ts'ebetso e mengata ea ts'ebetso, bacteriostatic, e tlamahang ho 50S subunit ea membrane ea ribosomal mme e thibela synthesis ea protheine seleng ea microbial. Mabapi le cocci e ntle ea gram, phello ea bactericidal e ka etsahala. E sebetsa khahlanong le Staphylococcus spp. (ho kenyelletsa penicillinase e hlahisang Staphylococcus epidermidis), Streptococcus spp. (ntle le Enterococcus spp), Streptococcus pneumoniae, Corynebacterium diphtheriae, spore- le e senang spore-form anaerobes, le cocaerophilic gram-positive cocci (ho kenyeletsoa Peptococcus spp. le Peptostreptococcus spp. Clostridium perfrinrate. (ho kenyeletsoa Bacteroides fragilis le Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., Eubacter spp. Actinomyces spp.

Boholo ba mefuta ea Clostridium perfringens e amehile ka moriana, leha ho le joalo, kaha mefuta e meng ea clostridia (Clostridium sporogenes, Clostridium tertium) e hanyetsana le moriana, boikemisetso ba lithibela-mafu bo khothaletsoa bakeng sa ts'oaetso e bakoang ke Clostridium spp.

Ka tšebeliso ea bongaka ha e sebetse khahlano le Mycoplasma pneumoniae, Haemophilus fluenzae, Helibacter pylori, Neisseria meningitidis, Neisseria gonorrhoeae, Ureaplasma urealyticum.

Pakeng tsa Dalacin C le lincomycin ho na le ho hanyetsa. E sebetsang kalafo ea asymptomatic diphtheria carriers (beke le beke ea ho ithuta, ka molomo).