Gliclazide Canon: litaelo tsa tšebeliso ea matlapa

Gliclazide Canon: litaelo tsa tšebeliso le litlhahlobo

Lebitso la Latin: Gliclazide Canon

Khoutu ea ATX: A10BB09

Motsoako o sebetsang: Gliclazide (Gliclazide)

Mohlahisi: tlhahiso ea Kanonfarma, CJSC (Russia)

Tlhaloso ea litlhaloso le foto: 07/05/2019

Litheko makaleng a litlhare: ho tloha ho li-ruble tse 105.

Glyclazide Canon ke lithethefatsi tse tsoang molomong oa sehlopha sa bobeli sa sulfonylurea.

Sokolla foromo le sebopeho

Foromo ea litekanyetso - matlapa a lokolotsoeng a emotsoeng: hoo e batlang e le bosoeu kapa bosoeu, ho nyaroloha hanyane ka hanyane, pota biconvex, 60 mg e ngoe le e ngoe e nang le mola o arohanang (Gliclazide Canon 30 mg: li-pcs tse 10. Lipaketsong tsa blister, ka lipakete tse 3 kapa tse 6 tsa katse) , Li-pcs tse 30. liphuthehong tsa blister, ka lebokoseng la mekotla ea 1 kapa 2, Canon Glyclazide 60 mg: li-pcs tse 10. ka mekotleng ea blister, ka mekotleng ea karete ea likarete tse 3 kapa tse 6, likhomphutha tse 15 ho mekotla ea blister, ho karete ea karete ea 2 kapa 4, ho Sekete se seng le se seng se na le litaelo tsa tšebeliso ea Glyclazide Canon).

Letlapa la 1

• ntho e sebetsang: gliclazide - 30 kapa 60 mg,
• likarolo tse thusang (30/60 mg): magnesium stearate - 1,8 / 3.6 mg, cellcrystalline cellulose - 81.1 / 102.2 mg, oli ea limela e nang le hydrogen - 3.6 / 7.2 mg, hypromellose - 50 / 100 mg, colloidal silicon dioxide - 3.5 / 7 mg, mannitol - 10/80 mg.

Mofumahali

Glyclazide - sesebelisoa se sebetsang sa Glyclazide Canon, ke sepheo sa sulfonylurea mme ke moemeli oa hypoglycemic bakeng sa tsamaiso ea molomo. E fapana le lithethefatsi tse tšoanang ha ho na le reng e nang le heterocyclic e nang le N e nang le endocyclic bond.

Gliclazide e thusa ho fokotsa khatello ea tsoekere ea mali, e fanoang ke ho phahamisa secretion ea insulin ke lisele tsa beta tsa lihlekehleke tsa Langerhans. Nako ea phello ea ho eketsa litaba tsa insulin ea postprandial le C-peptide e ntse e tsoela pele kamora lilemo tse peli tsa kalafo. Ntho ena, ntle le ho ama metabolism ea carbohydrate, e na le thepa ea hemovascular and antioxidant.

Ha o etsa kopo ea Glyclazide Canon bakeng sa kalafo ea mofuta oa tsoekere ea lefu la tsoekere la 2, tlhoro ea pele ea "insulin secretion" e khutlisoa ka lebaka la ts'ebeliso ea glucose le keketseho ea karolo ea bobeli ea insulin secretion. Ka lebaka la ho hlohlelletsa, ho bakoang ke ho hlahisoa ha tsoekere kapa tšebeliso ea lijo, ho na le keketseho e kholo ho secretion ea insulin.

Ketso ea gliclazide e etselitsoe ho fokotsa kotsi ea "thrombosis" e nyane ea mali, e bakoang ke phello ea methapo e ka amanngoeng le nts'etsopele ea mathata a lefu la tsoekere. Tsena li kenyelletsa: thibelo e sa lekanyetsoang ea khokahanyo ea liplatelete le ho kenella ka bongata₂beta-thromboglobulin). Ntle le moo, Gliclazide Canon e ama ho tsosolosoa ha ts'ebetso ea fibrinolytic ea vasotine endothelium le keketseho ea matla a activator ea tisy plasminogen.

Ha ho bapisoa le taolo e tloaelehileng ea glycemic (e ipapisitseng le sephetho sa lipatlisiso tsa ADVANCE), ka lebaka la taolo e ntlafalitsoeng ea glycemic e thehiloeng kalafong ea glycazide ea nako e telele, boleng ba sepheo sa HbAlc (glycosylated hemoglobin)

Matšoao a ho sebelisoa

Moriana ona o reretsoe kalafo ea mellitus e sa itšetleheng ka insulin (mofuta oa 2), haeba khalemelo ea phepo e nepahetseng, boima le ho ikoetlisa li sa hlahise litholoana. Ntle le moo, moriana o loketse ho thibela mathata a mofuta oa lefu la tsoekere la mofuta oa 2 (lefu la Micro-and macro-vascular pathologies), bakeng sa kalafo ea lefu la morao-rao la lefu lena (latent, leo ho lona ho se nang matšoao a lefu la tsoekere), ka botenya ba tšimolohong ea molaotheo oa kantle ho naha.

Mefuta le sebopeho sa tokollo

Lintho tse latelang li kenyelelitsoe ka har'a moriana:

• E sebetsang: gliclazide 30 kapa 60 mg.
• Motlatsi: hydroxypropyl methylcellulose, colloidal silicon dioxide, mannitol, E572 (magnesium stearate), oli ea limela ea hydrogenated, cellcose ea microcrystalline.

Gliclazide canon e etselitsoe tsamaiso ea molomo. Foromo ea litekanyetso: matlapa a lokolotsoeng a tsitsitseng. Moetsi o fana ka litekanyetso tse 'maloa tsa litekanyetso: 30 le 60 mg. Matlapa a chitja a pota-potile ka hohle, a hlakileng a tsoa mahlakoreng a mabeli, 'mala o mosoeu (' mele oa 'mabole.

Pholiso ea thepa

Mochine oa ts'ebetso o amana le phello ea metsoako ea sulfonylurea ho li-receptor liseleng tsa "pancreatic". Ka lebaka la karabelo e etsahalang seleng ea cellular, liteishene tsa KatiF + li koetsoe 'me likarolo tsa β-cell li hlotsoe. Ka lebaka la ho putlama ha lisele tsa lisele, ho buloa liteishene tsa Ca +, li-ion tsa calcium li kena li-β-cell. Insulin e ea lokolloa ebe e kenella maling.

Ka nako e ts'oanang, moriana o theola lisele tsa manyeme hanyane ka hanyane, o baka allerg, mafu a ka mpeng, o eketsa menyetla ea hypoglycemia, joalo-joalo. E sebetsa ho fihlela pokello ea ts'ebetso ea insulin ea manyeme e felile. Ke ka lebaka leo ka tšebeliso e telele ea lithethefatsi, tšusumetso ea eona ea pele ho secretion ea insulin e fokotsehang. Leha ho le joalo, kamora ho phomola ho amoheloeng, karabelo ea li-cells-cell e khutlisetsoe.

Gliclazide canon e kenella ka potlako le ka botlalo ho tsoa ho lijo tse silang lijo. Kamora ho ja, boemo ba tsoekere bo nyoloha, ka hona karolo e ka sehloohong ea secretion ea insulin e etsahala nakong ena. Ts'ebeliso e kopaneng ea lithethefatsi le lijo li ka fokotsa tekanyo ea ho monya. Hyperglycemia e matla le eona e ka fokotsa lebelo la monko mme sena se bakoa ke taba ea hore pathology e tsamaisana le ho fokotseha hoa ts'ebetso ea makoloi ka seterateng sa ka mpeng.

Phello ea kalafo e qala nakong ea lihora tse 2-3 kamora hore a tsamaiso. Phaello e phahameng ea ntho e sebetsang maling e bonoa ka mor'a lihora tse 7-10. Nako ea ketso - 1 letsatsi. E pepesitsoe ka har'a moroto, esita le ka tšilo ea lijo.

Mokhoa oa kopo

Litsenyehelo tse tloaelehileng tsa lithethefatsi ke li-ruble tse 60 - 150 -. 30 mg - 110 li-ruble.

Moriana ona o loketse batho ba baholo feela. Motsoako ka letsatsi - 30-120 mg. Tekanyo e nepahetseng e lokela ho laeloa ke ngaka e eang hloko e nahanela sethala sa lefu lena, matšoao a lona, ​​tsoekere e potlakileng le lihora tse peli kamora ho ja, lilemo tsa mokuli le karabelo ea motho ka mong kalafong. E le molao, litekanyetso tsa pele tsa kalafo ea lefu la tsoekere ha li fetele ho 80 mg, le bakeng sa thibelo kapa kalafo ea tlhokomelo - 30-60 mg.

Haeba ho senoloa hore litekanyetso li sa sebetse hantle, ka nako eo e ea eketseha butle-butle. Ntle le moo, phetoho e 'ngoe le e' ngoe kalafong ea kalafo ha ea lokela ho etsoa pele ho nako ea libeke tse peli ho tloha qalong ea kalafo. Haeba tekanyetso e le 'ngoe kapa ho feta e hlotsoe, ho ke ke ha khoneha ho eketsa litekanyetso tsa tekanyetso e latelang.

Ho khothalletsoa ho nka tekanyetso ea letsatsi le letsatsi nako e 1 ka ho koenya letlapa lohle. Ho thibela ho kopanya sethethefatsi sa lithethefatsi le lijo, ho molemo ho sebelisa lithethefatsi halofo ea hora pele ho lijo.

Nakong ea kemaro le kanyeso

Litlamorao tsa sethethefatsi nakong ea kemolo le ka pōpelong ha se utloisisoe hantle. Ka hona, taelo ea tšebeliso e thibela ts'ebeliso ea lithethefatsi nakong ea ho beleha ngoana le HB.

Contraindication le Boitlhokomelo

Ho amoheloa hoa senyeha ho na le maemo a latelang:

• lefu la tsoekere le itšetlehileng ka insulin (mofuta oa 1),
• lefu la tsoekere ketoacidosis, koma,
• sebete se matla, lefu la liphio,
• nako ea ho emara, GV,
• lilemo tsa bana
• hypersensitivity ea lintho tse sebopeho sa moriana.

Hypoglycemia e tsamaisana le ho fokotseha ha khatello ea maikutlo, ho tsekela, ho ferekana ha moea le matšoao a mang. Motho ea nang le lefu la tsoekere o lokela ho hlokomela maemo a lefu lena 'me a be hlokolosi ha a etsa lintho tse hlokang hore a potlakeloe (ho etsa mohlala, ho khanna koloi).

Tšebelisano ea lithethefatsi

Kameho ea meriana e ka ntlafatsoa ke lithethefatsi tse ling, tse eketsang monyetla oa ho ba le hypoglycemia. Glyclazide Canon e kopantsoe hammoho le Miconazole. Ha ho kgothaletswe ho kopanya ho kenella le phenylbutazone, ethanol.

Motsoako oa lithethefatsi le li-agents tse ling tsa hypoglycemic (insulin, acarbose), beta-blockers, li-inhibitors tsa ACE, litokisetso tsa calcium, β-blockers li hloka tlhokomeliso, hobane e ntlafatsa phello ea hypoglycemic.

Meriana e latelang e nyenyefatsa phello ea kalafo:

• Danazole - o na le lefu la tsoekere,
• Chlorpromazine - e eketsa tsoekere ea mali, e fokotsa secretion ea insulin.

Litla-morao le ho sebelisa overdose haholo

Gliclazide canon e mamelloa hantle ke bakuli. Moriana o sebetsa haholo ho feta sulfonylureas ea pele. Sena se lumella ts'ebeliso ea litekanyetso tse tlase tsa lithethefatsi, tse fokotsang menyetla ea karabelo tse mpe kamora ho sebelisoa.

Empa ka tšebeliso ea nako e telele, litla-morao li ka hlaha. E 'ngoe ea lintho tse atisang ho etsahala hampe ke tsoelo-pele ea hypoglycemia, haholoholo bathong ba lilemo tse fetang 50, ba nang le mabaka a rerang esale pele:

• Ts'ebetso e le 'ngoe ea meriana e mengata.
• Ho fokotsa boima ba 'mele.
• Ho se je lijo tse lekaneng.
• Ts'ebeliso ea joala.
• Ho senyeha ha liphio, sebete, jj.

Hape, khahlano le nalane ea ho ja khafetsa, bakuli ba atisa ho ba le takatso e matla ea lijo, e lebisang lethathamong la liponto tse eketsehileng. Bakeng sa ho thibela boima ba 'mele, ho khothalletsoa ho latela lijo tsa hypocaloric.

Litlamorao tse ling tse mpe tsa ho nka le ho kenyelletsa:

• Mathata a ka mpeng: ho nyekeloa ke pelo, lets'ollo, ho hlonama / mpeng, ho hlatsa.
• Allergy (rashes, ho hlohlona ha letlalo).
• CNS: ho teneha, ho hloka boroko, khatello ea maikutlo, ho hema ka thata, ho se khone ho tsepamisa mohopolo, pherekano, ho fokotseha, ho tšoenyeha, ho tšoenyeha, tšabo.
• Lisebelisoa tsa moea, pelo: palpitations, khatello ea mali e eketsehileng, phokolo ea mali.
• Sebete, pampitšana ea biliary: cholestatic jaundice, hepatitis.
• Ho senyeha hoa pono, pallor ea letlalo.

Litla-morao tsena ha li na seoelo, ho bakuli ba 1-2%. Maemong a karabelo e kaholimo, tsamaiso e lokela ho emisoa.

Ho khothalletsoa ho qoba tekanyetso e phahameng ea lithethefatsi kotsi ea hypoglycemia ea eketseha, 'me ho tsitsisoa ha lisele tsa β lisele lia li theola. Ho na le monyetla oa ho holofatsa maemo a behang bophelo kotsing ea hypoglycemia, ho fihlela ho "edema" ea likhoerekhoere, ho ts'oaroa, komello. Maemong ana, ho hlokahala sepetlele ka potlako le thuso e tšoanelehang ea basebetsi ba bongaka.

Phekolo ea overdose e etsoa ka ho kenella glucose kapa ka ho kenya tharollo ho / ho (50%, 50 ml), ka lefu la mokokotlo - in / in Mannitol. Ho kenyelletsa moo, ho hlokahala tlhahlobo e hlophisehileng ea maemo a tsoekere matsatsing a mabeli a tlang.

Moetsi: Lab. Indasteri ea Basebeletsi, Fora.

Karolelano ea litšenyehelo: 310 rub

Ntho ea mantlha: gliclazide. Letlapa la litekanyetso.

Melemo: ka seoelo e baka litla-morao (hoo e ka bang 1% ea batho ba nang le lefu la tsoekere), ho sebetsa hantle haholo, butle-butle ho fokotsa tsoekere, ho fokotsa sebopeho sa mali, litaelo tse bonolo tsa ho sebelisoa.

Mathata: litšenyehelo tse phahameng, butle-butle li theoha li-β-cell.

Moetsi: Ranbaxi Laboratories Ltd., India.

Karolelano ea litšenyehelo: 200 rub Ntho ea mantlha: gliclazide. Letlapa la litekanyetso.

Melemo: ka nepo e ka emisang matšoao a tsoekere ea mali, ho boloka matla ho β-lisele ho fapana le sulfonylureas ea pele, e fokotsa menyetla ea thrombosis.

Mathata: ho ba thata ho e fumana litlolong tsa meriana, ho e sebelisa khafetsa ho lebisa ho nts'etsopele ea "mellitus" e amanang le lefu la tsoekere.

Fomu ea tokollo, sebopeho le sephutheloana

Litaelo tse teng bakeng sa ts'ebeliso ea Canon Glyclazide li bonts'a karolo ea eona ea sehlopha sa lithethefatsi tse fokotsang tsoekere ea mali, tataiso ea molomo le taba ea hore e kenyelletsoa sehlopheng sa lits'oaetso tsa sulfonylurea molokong oa bobeli. E na le sebopeho se potolohileng letlapa, se bonoang ka mahlakoreng ka bobeli, se tšoeu. Ho latela maikutlo a Glyclazide Canon, li tšoauoa ke khanya e bobebe. Karolo ea matlapa ke tokollo e tsitsitseng, e bolelang hore ba na le tekanyo e fokolitsoeng le khafetsa ea litekanyetso, empa li na le phello e tšoarellang nako e telele. Sebaka se ka sehloohong ke gliclazide ka bongata ba 30 mg le 60 mg. Lethathamo la likarolo tse ling le hlahisoa ke mannitol, magnesium stearate, colloidal silicon diode, li-cellcrystalline cellulose.Gliclazide Canon ea Moscow le libaka tse ling li theko e tlaase haholo bakeng sa baahi ba etsang ts'ebetso ea pholiso ba sebelisa lithethefatsi tsena.

Ketso ea pharmacological

Mosebetsi o ka sehloohong oa Canon Gliclazide ke ho susumetsa tlhahiso ea lisele tsa "insulin" ka har'a manyeme. Motsoako ona o boetse o thusa ho eketsa insulin maemong a pherekano. Ka mantsoe a mang, e na le boikarabello ba ho susumetsa matla a li-enzyme ka har'a lisele. E khutsufatsa nako ea nako pakeng tsa lijo le ho qaleha ha tokollo ea insulin. E ama ho qaleha ha tlhoro ea pele ea ho lokolloa ha insulin le ho fokotseha ha tlhoro ea postprandial ea hyperlycemia. Glyclazide Canon e thusa ho fokotsa ho kopana ha liplatele le ho khomarela, e liehisa sebopeho sa parietal thrombi, mme e ntlafatsa ts'ebetso ea methapo ea methapo. Bo ikarabella bakeng sa ho thatafala ha methapo ea methapo. E boetse e na le thepa ea anti-atherogenic, e bonahatsang ho fokotseha ha cholesterol ea mali, keketseho ea ho bokelloa ha HDL-C, le ho fokotseha ha palo ea li-radicals tsa mahala tse teng. E thibela atherosclerosis le microthrombosis, sebopeho sa bona. Fokotsa khatello ea methapo ho adrenaline mme e na le phello e ntle ho ntlafatseng microcirculation. Tšebeliso ea nako e telele ea Canon Glyclazide e fokotsa proteinuria ho lefu la tsoekere. Ho tlosoa ha moriana o tsoang ka mpeng ho ea ka mpeng ho etsahala ka potlako ho feta ha Canon Gliclazide analogues. Motsoako o etsahala ka liphiong o sebelisa li-metabolites, mme o ka bang 1% ka moroto.

Gliclazide Canon e etselitsoe bakuli ba fumaneng ho ba teng ha mofuta oa lefu la tsoekere la mofuta oa 2, ho etsa hore maemo a fokotsehe, hape le ho eketsa mamello ea koloi le mafolofolo, le ka nako eo ho eona lethathamo la khalori e tlase le sa hlahiseng melemo. E loketseng e le prophylaxis khahlanong le ho ata ha lefu la tsoekere: e le ho thibela kotsi ea ho eketsoa ke microvascular, khahlano le ho phahama ho hoholo ha methapo - ho otla le ho nyekeloa ke pelo, ka ho lekola leihlo le ntlafalitsoeng la glycemic.

Litlamorao

Litla-morao tse tsoang ho ts'ebeliso ea lithethefatsi ke tsena: - lefu la hypoglycemic le bakoang ke ho ja ka mokhoa o sa lekaneng le litekanyetso tse sa nepahalang, - hlooho ea hlooho, - mokhathala, - ho fufuleloa ka sekhahla, - ho otla ha pelo ka potlako, - bofokoli le ho otsela, - khatello e phahameng ea mali, - ponahalo ea ho tšoenyeha ho feteletseng. - mathata a ho robala, - boemo ba arrhythmia, - letsoalo le bohale, - ponahalo ea mathata ka lisebelisoa tsa puo le ho fifala ha pono ea pono, - maikutlo a liehang, - ho ferekana, - boemo ba khatello ea maikutlo, - ho thothomela qetellong styah - oela coma le, - fainting, - tsitsipanya, - boemo ba ho hloka thuso - lebaka la ho hloka boitšoaro - ho hlaha ha bradycardia. Litho tsa tšilo ea lijo li arabela ka ho bonahala ha lets'ollo, ho hlatsa, bohloko ba ka mpeng, mathata a setofo, ka linako tse ling ho ba le ho se sebetse hantle ha sebete.Ka hepatitis le jaundice ea cholestatic, ho na le tlhoko e potlakileng ea ho hlakola kalafo, ho eketsa matla a hempatic transaminases, alkaline phosphatase. Litho tse ikarabellang bakeng sa hematopoiesis li fana ka matšoao a sithabetsang a mongo hematopoiesis. Ho hlaseloa habonolo ke lintho tse ling ho bonahala ka ho hlaha ha leholiotsoana le ho potlaka ha 'mele, erythema le urticaria. Lintho tse tsoang ho Sulfonylurea li fetoha ka vasculitis, erythropenia, hemolytic anemia, pancytopenia, agranulocytosis le ts'ebetso ea sebete e sa sebetseng, e ka behang bophelo kotsing.

Bongata

Boemong ba ho feta tekanyetso e lumellehang ea Canon Glyclazide, ho na le monyetla oa lefu la hypoglycemic, boemo ba ho tepella le kotsi ea ho oela ka har'a coma ea hypoglycemic. Bakeng sa kalafo ea bakuli ba tsebang, ho hlokahala hore ho tšeloe tsoekere kahare. Ho boetse ho na le kotsi ea ho ts'oaroa, mafu a tsoang ho neurology, ka lebaka la boemo bo hlobaetsang ba hypoglycemic. Boemo bona bo hloka karabelo e potlakileng ea lingaka le ho kena sepetlele ka potlako. Tlas'a mohopolo kapa ho ananeloa ha coma ea hypoglycemic, ente ea tharollo ea tsoekere ea 40% ka molumo oa 50 ml e hlokahala ka potlako, ka hona, molemong oa ho boloka sekhahla se lekaneng sa tsoekere, motsoako oa dextrose oa 5% o kenngoa ka mokhoa o fokolang. Lihora tse 'maloa tse latelang ka mor'a hore motho ea hlokahalitsoeng a itlhahise ho yena, e le ho thibela ho khutla ha lefu la hypoglycemic, o hloka ho mo fepa lijo tse nang le lik'habohaedreite tse bonolo tse jang lijo. Bakeng sa lihora tse ling tse 48, boloka mokuli a le haufi le ho shebelloa le ho lekola boemo ba tsoekere ea mali ea mokuli. Ho shebeloa ho eketsehileng ha lingaka ho itšetlehile ka boemo ba hae ba bophelo bo botle. Boemong bo tšoanang, ho latela ho tlama ha gliclazide le liprotheine tsa plasma, tlhoekiso ea dialysis e ke ke ea sebetsa.

Ho sebelisana le lithethefatsi

Motsoako oa Canon Glyclazide le anticoagulants ke taba ea bohlokoa, hobane setlhare se ntlafatsa phello ea bona, e hlokang tokiso ea tekanyetso. Miconazole e potlakisa ho mpefatsa boemo ba hypoglycemic. Pele le ka mora phenylbutazone, ho na le tlhoko ea ho lekola le ho hlahloba boemo ba tsoekere maling le ho lokisa moo boholo ba glyclazide e nkiloeng, ka lebaka la hore e kenya letsoho ts'ebetsong ea phello ea hypoglycemic. Mithethefatsi, ka boteng ba ethyl alcohol ka sebopeho, e ka ntlafatsa hypoglycemia, 'me ea ntšetsa pele hypoglycemic coma. Ts'ebeliso e tšoanang ea Canon Glyclazide e nang le meriana ea sehlopha sa eona (insulin, acarbose), beta-blockers, fluconazole, monoamine oxidase inhibitors, H2-histamine receptor blockers, li-anti-insulin tse seng khahlanong le ts'oaetso, li-sulfonamides li mpefatsa litlamorao tsa hypoglycemic le hypoglycemic le aggravations. Phello ea Diabetogenic e na le danazol. Ho fokotsa sebopeho sa insulin le ho bokellana ha eona maling ho baka litekanyetso tse phahameng tsa chlorpromazine. Tsamaiso ea terbutaline ka methapong, salbutamol le ritodrine e eketsa le ho bokella tsoekere. Ho na le tlhoko ea ho lekola boemo ba eona le ho etsa liphetoho tseleng e khethiloeng ea kalafo ea insulin.

Litaelo tse khethehileng

Ts'ebetso ea kalafo e nang le Glyclazide Canon e tsamaisana le phepelo ea phepo e tlase ea khalori, lijo tse phetseng hantle tse phehellang ka kenyelletso e tlamang ea lijo tsa hoseng le palo e khotsofatsang ea lik'habohaedreite tse tlang. Ka lebaka la tsamaiso e ts'oanang ea likhahla tsa sulfonylurea, hypoglycemia e khona ho nts'etsapele, ka linako tse ling e sa fetele ntle le ente ea glucose le ho beoa sepetlele. Ho matahanya le joala, ho nka linoko tse ngata tsa hypoglycemic ka tsela e tšoanang, ho ikoetlisa ka ho feteletseng ho ka baka hypoglycemia. Ho sithabela maikutlo, maikutlo mabapi le lijo ho hloka hore moriana o fetole lithethefatsi. Likotsi tse bohloko tsa 'mele, ho ba teng ha ho chesa haholo, mafu a bakoang ke ts'oaetso e fapaneng le tlhoko ea ts'ebetso ea bongaka e fumanehang, ke mabaka a hlokang hore ho hlakoloe ho nka Glyclazide Canon. Ts'ebetso ea kalafo ka moriana e ka ama ho ts'oaroa le karabelo e potlakileng, ka hona, ho se ho se hokae, u hloka ho tlohela ho lula kamorao ho lebili le lits'ebetso tsa basebetsi tse hlokang ho tsepamisa maikutlo haholo. Ts'ebetso ea kalafo e lokela ho tsamaisana le qeto e hlophisehileng ea boemo ba tsoekere le glycosylated hemoglobin maling, le ho kenella ha eona ka har'a moroto.

Glyclazide Canon

Matlapa a Sirelelitsoeng a Solo e tšoeu kapa e batla e tšoeu, e pota-pota, e na le biconvex, e nang le kotsi, ho nyants'oa hanyane ho lumelloa.

Baeti: hypromellose (hydroxypropyl methylcellulose) - 100 mg, colloidal silicon dioxide - 7 mg, mannitol - 80 mg, magnesium stearate - 3.6 mg, oli ea meroho e nang le hydrogen - 7.2 mg, microcrystalline cellulose - 102.2 mg.

Li-pcs tse 10 - Liphutheloana tsa lithutsoana (3) - lipakete tsa karete ea karete. li-10 likhomphutha. - Liphutheloana tsa lithutsoana (6) - lipakete tsa likarete tse 15 likhomphutha. - liphutheloana tsa lithutsoana (2) - lipakete tsa karete.

Li-pcs tse 15. - Liphutheloana tsa lithutsoana (4) - lipakete tsa karete.

Mofumahali

Kamora ho tsamaisoa ka molomo, e kenella ka potlako ho tsoa mokokotlong oa lijo. Cmax maling e fihlella lihora tse ka bang 4 ka mor'a ho nka tekanyetso e le 'ngoe ea 80 mg.

Plasma protein e tlamang ke 94.2%. Vd - e ka ba 25 l (0,35 l / kg boima ba mmele).

E tšelisoa ka har'a sebete ho hlaha metsoako e robeli ea metsoako. Metabolite ea mantlha ha e na phello ea hypoglycemic, empa e na le phello ho microcirculation.

T1 / 2 - lihora tse 12. E pepisoa haholo ke liphio ka mokhoa oa metabolites, e ka tlase ho 1% e pepesitsoeng ka har'a moroto o sa fetohe.

Type 2 lefu la tsoekere la mellitus le sa sebetsang hantle kalafo ea ho ja, ho ikoetlisa le ho theola boima ba 'mele.

Thibelo ea mathata a mofuta oa 2 lefu la tsoekere: ho fokotsa kotsi ea mathata a amanang le lefu la sethoathoa (myocardial infarction, stroke).

Glyclazide MV 30 mg le MV 60 mg: litaelo le litlhahlobo bakeng sa lefu la tsoekere

Gliclazide MV ke e 'ngoe ea meriana ea lefu la tsoekere e atisang ho sebelisoa. Ke karolo ea moloko oa bobeli oa litokisetso tsa sulfonylurea 'me e ka sebelisoa ho monotherapy le matlapeng a mang a theolang tsoekere le insulin.

Ntle le phello ea tsoekere ea mali, gliclazide e na le phello e ntle sebopeho sa mali, e fokotsa khatello ea oxidative, e ntlafatsa microcirculation. Setlhare ha se na mathata a sona: se thusa ho nona, ka ho sebelisoa nako e telele, matlapa a felloa ke matla. Esita le tekanyetso e nyane ea gliclazide e na le hypoglycemia, kotsi e ngata haholo botsofaling.

Tlhahisoleseling ka kakaretso

Setifikeiti sa ho ngolisa bakeng sa Gliclazide MV se fanoa ke k'hamphani ea Russia Atoll LLC. Lithethefatsi tlasa konteraka li hlahisoa ke k'hamphani ea meriana ea Samara Ozone. E hlahisa le ho beha lipilisi, 'me e laola boleng ba eona.

Gliclazide MV e ke ke ea bitsoa sehlahisoa sa lapeng ka ho felletseng, kaha ho rekisoa setlhare sa litlhare bakeng sa eona (eona glyclazide) Chaena. Leha ho le joalo, ha ho letho le lebe le ka buuoang ka boleng ba moriana.

Ho latela litsebi tsa lefu la tsoekere, ha ho hobe ho feta lefu la tsoekere la Mofora ka sebopeho se tšoanang.

Kakaretso ea MV ka lebitso la moriana e bonts'a hore ntho e sebetsang ho eona e lokollotsoe, kapa e tsoetse pele, ho lokolla.

Glyclazide e siea letlapa ka nako e nepahetseng le sebakeng se nepahetseng, se netefatsang hore ha e kene maling a hang-hang, empa ka likarolo tse nyane. Ka lebaka lena, kotsi ea litlamorao tse sa rateheng e fokotsehile, moriana o ka nooa hangata.

Haeba sebopeho sa letlapa le tlotsoa, ​​ketso ea lona ea nako e telele e lahlehile, ka hona, litaelo tsa tšebeliso ha e khothalletse ho e khaola.

Glyclazide e kenyelelitsoe lethathamong la meriana ea bohlokoa, ka hona, li-endocrinologists li na le monyetla oa ho fana ka tsona ho lefu la tsoekere mahala. Hangata, ho latela lengolo la ngaka, ke MV Gliclazide ea lapeng eo e leng analog ea Diabeteson ea mantlha.

Moriana o sebetsa joang?

Li-gliclazide tsohle tse tšoaretsoeng ka har'a tšilo ea lijo li kenella maling 'me moo li kopana le liprotheine tsa eona. Ka tloaelo, tsoekere e kenella liseleng tsa beta ebile e hlohlelletsa li-receptor tse ikhethang tse etsang hore insulin e tsoe. Glyclazide e sebetsa ka molao-motheo o tšoanang, e hlahisang ka mokhoa oa tlhaho tlhahiso ea hormone.

Kameho ea tlhahiso ea insulin ha e felle feela ho phello ea MV Glyclazide. Setlhare se khona ho:

1. Fokotsa ho hanyetsa insulin. Liphetho tse ntle ka ho fetisisa (kutloelo-bohloko ea insulin ka 35%) li bonoa liseleng tsa mesifa.
2. Fokotsa motsoako oa tsoekere ke sebete, ka tsela eo, o lekanye ho potlaka ha eona.
3. Thibela mali.
4. Ho matlafatsa synthesis ea nitric oxide, e kenyelletsoang ho laola khatello, ho fokotsa ho ruruha, le ho ntlafatsa phepelo ea mali ho lithishu tse kenellang.
5. Sebetsa e le antioxidant.

Fomola foromo le litekanyetso

Letlapeng la Gliclazide MV ke 30 kapa 60 mg ea ntho e sebetsang.

Lithako tse thusang ke: cellulose, e sebelisoang e le moemeli oa bulking, silica le magnesium stearate joalo ka emulsifiers.

Matlapa a mmala o mosoeu kapa oa tranelate, o kentsoeng ka lithupa tsa likotoana tse 10-30. Ka pakete ea lilakane tse 2-3 (matlapa a 30 kapa a 60) le litaelo. Glyclazide MV 60 mg e ka aroloa ka halofo, hobane sena se na le kotsi matlapeng.

Setlhare se lokela ho nooa nakong ea lijo tsa hoseng. Gliclazide e sebetsa ho sa tsotelehe ho ba teng ha tsoekere maling. E le hore hypoglycemia e se ke ea etsahala, ha ho lijo tse lokelang ho ts'oaroa, e 'ngoe le e' ngoe ea tsona e lokela ho ba le palo e lekanang ea lik'habohaedreite. Ho eletsoa ho ja makhetlo a 6 ka letsatsi.

Melao ea khetho ea litekanyetso:

Litaelo tse qaqileng tsa tšebeliso

Ho latela likhothaletso tsa bongaka tsa Ministry of Health of the Russian Federation, gliclazide e lokela ho laeloa ho khothaletsa secretion ea insulin. Ka ho utloahalang, ho haella ha homone ea hau ho lokela ho netefatsoa ke ho hlahloba mokuli. Ho latela maikutlo, hangata sena ha se etsahale. Lingaka le li-endocrinologists li fana ka litlhare "ka leihlo".

Ka lebaka leo, ho feta palo e hlokahalang ea insulin e patiloe, mokuli o lula a batla ho ja, boima ba hae bo ntse bo eketseha butle-butle, 'me matšeliso a lefu la tsoekere a lula a sa lekana. Ntle le moo, lisele tsa beta tse nang le mokhoa ona oa ts'ebetso li timetsoa ka potlako, ho bolelang hore lefu lena le ea mokhatlong o latelang.

Mokhoa oa ho qoba litlamorao tse joalo:

1. Qala ka tieo ho latela lijo tsa batho ba nang le lefu la tsoekere (tafoleng ea 9, palo e lumelletsoeng ea lik'habohaedreite e khethoa ke ngaka kapa mokuli ka boeena ho latela glycemia).
2. Kenyelletsa motsamao o mafolofolo tsamaisong ea letsatsi le letsatsi.
3. Fokotsa boima ba 'mele ho tloaelehileng. Mafura a mangata a mpefatsa lefu la tsoekere.
4. Ho nona glucophage kapa analogees ea eona. Sekhahla se nepahetseng ke 2000 mg.

Mme feela haeba mehato ena e sa lekana le tsoekere e tloaelehileng, o ka nahana ka gliclazide. Pele o qala kalafo, ho bohlokoa ho nka liteko tsa C-peptide kapa insulin ho etsa bonnete ba hore tlhahiso ea lihormone ha e na mathata.

Ha hemoglobin ea glycated e phahame ho feta 8,5%, MV Gliclazide e ka fuoa hammoho le lijo le metformin ka nakoana, ho fihlela lefu la tsoekere le buselitsoe. Kamora moo, taba ea ho khaotsa lithethefatsi e etsoa qeto ka bomong.

U ka nka joang nakong ea kemaro

Litaelo tsa tšebeliso li thibela kalafo le Gliclazide nakong ea kemolo le ho lactation. Ho ea ka karohano ea FDA, sethethefatsi sena ke sa sehlopha sa C. Sena se bolela hore se ka ama hampe tsoelo-pele ea lesea, empa ha se bake liphapang tsa tlhaho ea setho. Gliclazide e sireletsehile ho nka sebaka sa kalafo ea "insulin" pele ho ima, maemong a feteletseng - qalong.

Monyetla oa ho anyesa le gliclazide ha o e-so hlahlojoe. Ho na le bopaki ba hore litokisetso tsa sulfonylurea li ka fetela lebese mme tsa baka hypoglycemia baneng, ka hona ts'ebeliso ea bona nakong ena e thibetsoe ka thata.

Ho Glyclazide MV e kentsoe khang

Ke eng e ka nkeloang

Gliclazide ea Russia ha e theko e phahameng, empa ho e-na le moriana oa boemo bo holimo, theko ea ho kenya Gliclazide MV (30 mg, likotoana tse 60) e fihla ho li-ruble tse 150. Pheta hape ka li-analogues ha feela matlapa a tloaelehileng a sa rekisoe.

Lithethefatsi tsa pele ke Diabeteson MV, lithethefatsi tse ling tsohle tse nang le sebopeho se le seng, ho kenyeletsoa Gliclazide MV ke li-generics, kapa likopi. Theko ea lefu la tsoekere e batla e phahame makhetlo a 2-3 ho feta lihlahisoa tsa eona.

Glyclazide MV analogues le bathusi ba ngolisitseng ho Russian Federation (ho bontšitsoe feela litokisetso tse lokisitsoeng tsa tokollo):

• Glyclazide-SZ e hlahisoang ke Severnaya Zvezda CJSC,
• Golda MV, Pharmasintez-Tyumen,
• Gliclazide Canon e tsoang Canonpharm Production,
• Glyclazide MV Apotheken, Apotekkhimfarm,
• Diabetalong, moetsi oa MS-Vita,
• Gliklada, Krka,
• Glidiab MV from Akrikhin,
• Tlhahiso ea Diabefarm MV Pharmacor.

Theko ea li-analogues ke li-ruble tse 120-150 ka sephutheloana. Gliklada e entsoeng ka Slovenia ke sethethefatsi se theko e boima ho feta lenaneng lena, pakete e bitsa li-ruble tse 250.

Litlhahlobo tsa lefu la tsoekere

E hlahlojoe ke Sergei ea lilemo li 51. Lefu la tsoekere la lefu la tsoekere lilemo tse ka bang 10. Haufinyane, tsoekere e fihlile ka 9 hoseng, ka hona Glyclazide MV 60 mg e laetsoe. U hloka ho e noa hammoho le moriana o mong, Metformin Canon.

Ka bobeli lithethefatsi le lijo li fana ka sephetho se setle, motsoako oa mali o ile oa khutlela ho tloaelehileng ka beke, kamora khoeli e emisitse ho emisa maoto. Ke 'nete, ka mor'a hore karolo e' ngoe le e 'ngoe ea lijo e hateloe, tsoekere e eketseha ka potlako, ebe butle-butle ea fokotseha ka letsatsi. Ha ho na litla-morao, ntho e 'ngoe le e' ngoe e mamelletsoe hantle.

Meriana e fanoa mahala mahala tleliniking, empa le haeba u reka u le mong, ha e theko e tlase. Theko ea Gliclazide ke 144, Metformin ke li-ruble tse 150. E hlahlojoe ke Elizabeth, ea lilemo li 40. Glyclazide MV e qalile ho noha khoeli e fetileng, setsebi sa endocrinologist se kenyellelitsoeng ho Siofor, ha tlhahlobo e ne e bontša hoo e ka bang 8% ea hemoglobin ea glycated.

Ha ke bue letho le lebe ka phello, o ile a fokotsa tsoekere kapele.Empa litla-morao li ile tsa nthibela ka botlalo monyetla oa ho sebetsa. Mosebetsi oa ka o hokahane le ho tsamaea kamehla; ha ke khone ho ja ka nako. Siofor o ile a ntšoarela liphoso tsa phepo e nepahetseng, empa ka Gliclazide palo ena ha ea ka ea feta, e ile ea lieha ho feta - hypoglycemia e ne e le hona moo.

'Me litoro tsa ka tse tloaelehileng ha lia lekana. E fihlile ntlheng ea hore ka mokokotlong o tlameha ho hlafuna bun e monate.

E hlahlobetsoe ke Ivan, ea lilemo tse 44. Haufinyane, ho fapana le Diabetes, ba ile ba qala ho fa Gliclazide MV. Qalong ke ne ke batla ho reka sethethefatsi sa khale, empa ke ile ka bala litlhahlobo mme ka etsa qeto ea ho leka e ncha. Ha ke utloe phapang, empa li-ruble tse 600. bolokiloe. Meriana ena ka bobeli e fokotsa tsoekere hantle ebile e ntlafatsa bophelo ba ka. Hypoglycemia ha e fumanehe seoelo ebile ke molato oa ka. Bosiu, tsoekere ha e oele, e hlahlojoe ka ho khetheha.

Lokolla liforomo le sebopeho

Setlhare se fumaneha ka mokhoa oa lipilisi, tse bonts'itsoeng ka tokollo e tsitsitseng. Moetsi o fana ka litekanyetso tse peli: 30 mg le 60 mg. Matlapa a na le sebopeho sa biconvex se chitja le 'mala o mosoeu. Sebopeho sa moriana se kenyeletsa:

• ntho e sebetsang (gliclazide),
• Lisebelisoa tse ling: colloidal silicon dioxide, li-microcrystals tsa cellulose, magnesium stearate (E572), hydroxypropyl methyl cellulose, mannitol, oli ea limela ea hydrogen.

Setlhare se fumaneha ka mokhoa oa lipilisi, tse bonts'itsoeng ka tokollo e tsitsitseng.

Ka tlhokomelo

Setlhare sena se ka sebelisoa bakeng sa ho sitisa ho senyeha ha mosebetsi oa liphio le sebete. Moriana o fanoa ka hloko litemaneng le maemong a latelang:

• e sa leka-lekanang kapa khaello ea phepo e nepahetseng
• mafu a endocrine
• mafu a matla a CVS,
• glucose-6-phosphate dehydrogenase ea haelloa,
• bokhoba ba joala
• bakuli ba tsofetseng (ba lilemo tse 65 le ho feta).

Phekolo le thibelo ea lefu la tsoekere

Tekanyetso ea pele ea lithethefatsi kalafo ea lefu la tsoekere e sa itšetleheng ka insulin le ts'ebeliso ea sulfonylurea ha ea lokela ho feta 75-80 g Bakeng sa thibelo, moriana o sebelisoa ho 30-60 mg / ka letsatsi.

Maemong ana, ngaka e lokela ho lekola boemo ba tsoekere ho mokuli lihora tse 2 ka mor'a ho ja le ka mpeng e se nang letho.

Haeba ho fumanoa hore tekanyetso e ne e sa sebetse, e eketsa ka matsatsi a 'maloa.

Setlhare se na le monyetla o motle oa ho hlasela 'mele. Leha ho le joalo, ka ho sebelisa lithethefatsi ka nako e telele, bakuli ba ka ba le karabelo e mpe.

Bakeng sa thibelo, moriana o sebelisoa ho 30-60 mg / ka letsatsi.

Karolong ea sebete le pampiri ea biliary

• hepatitis
• cholestatic jaundice.

• tahlehelo ea temoho,
• khatello e eketsehileng ea intraocular.

Setlhare sena se sebelisoa hammoho le sejo se tlase sa carb.

Ha o e nka, mokuli o lokela ho fana ka taolo ea khatello ea tsoekere maling.

Ha u sebelisa lithethefatsi, mokuli o lokela ho fana ka taolo ea khatello ea tsoekere maling.

Ho lefu la tsoekere mellitus karolong ea ho bola kapa ka mor'a ho buuoa, monyetla oa ho sebelisa litokisetso tsa insulin o lokela ho nahaneloa.

Ho beha lingoloa tsa Glyclazide Canon ea bana

Setlhare se thibetsoe ho sebelisoa ke bana ba banyenyane.

Bakuli ba seng ba tsofetse ba lumelloa ho sebelisa meriana ena litekanyetso tse tlase le tlasa tlhokomelo ea bongaka e haufi.

Ha hoa lumelloa ho sebelisa lipilisi tsena ka phello ea hypoglycemic ka li-pathologies tsa renal tse boletsoeng. Tekanyetso e khethoa ka bonngoe ho latela boemo ba bakuli ba nang le ts'ebetso ea renal e sa sebetseng.

Ha e khothalletsoe motsoako

Ha ho ratehe ho sebelisa meriana e nang le ethanol le lithethefatsi tse thehiloeng ho chlorpromazine ka nako e le ngoe le sethethefatsi seo ho buuoang ka sona.

Phenylbutazone, Danazole le joala li eketsa phello ea hypoglycemic ea lithethefatsi. Tabeng ena, ho molemo ho khetha moriana o mong o khahlanong le ho ruruha.

Mekhaako e hlokang ho ba hlokolosi

Ho kopana ha sethethefatsi le Acarbose, beta-blockers, biguanides, Insulin, Enalapril, Captopril le meriana e meng e thibelang ho ruruha e seng ea steroidal le meriana e nang le chlorpromazine e hloka tlhokomelo e khethehileng, hobane maemong ana ho na le kotsi ea hypoglycemia.

Litsebi tsa lefu la tsoekere

Arkady Smirnov, ea lilemo li 46, Voronezh.

Haeba ho se joalo bakeng sa lipilisi tsena, matsoho a ka a ka be a ile a theoha khale. Ke qetile nako e telele ke kula le lefu la tsoekere la mofuta oa 2. Moriana ona o laola tsoekere ea mali hantle. Ka litla-morao, ke ile ka kopana le ho nyekeloa hoa pelo feela, empa o ile a feta ka mor'a matsatsi a 'maloa.

Inga Klimova, ea lilemo li 42, Lipetsk.

Mme wa ka o na le lefu la tsoekere le sa ts'epeng insulin. Ngaka e ile ea mo fa lipilisi tsena. Joale o ile a qala ho nyakalla hape a latsoa bophelo hape.