Mokhoa oa ho sebelisa lithethefatsi Glyurenorm?

Pharadodynamics Glurenorm ke moemeli oa hypoglycemic ea molomo, e fumanoang molokong oa bobeli. Glurenorm e phahamisa sephiri sa insulin ea tsoelo-pele ka lisele tsa pancreatic,, e ntlafatsa ts'ebeliso ea tsoekere, e thibela ts'ebetso ea lipolysis.
Glurenorm e fokotsa ho hanyetsa ha insulin ka har'a sebete le li-adipose tiske ka ho eketsa palo ea li-insulin receptors le mekhoa e susumetsang ea post-receptor ka lebaka la ketso ea insulin. Ntho ea bohlokoa bakeng sa ketso ea hypoglycemic ea Glyurenorm ke ho ba teng ha insulin.
Litlamorao tsa ho theola sekhahla sa tsoekere ea mali se qala metsotso e 60-90 kamora taolo ea molomo ebe e fihla kamora lihora tse 2-3 kamora ho tsamaisoa.
Nako ea phello ea hypoglycemic ea Glurenorm ke lihora tse 8-10. Ka hona, Glurenorm e nkoa e le lithethefatsi tse nkang nakoana.
Ts'ebeliso ea sulfonylureas, e leng lithethefatsi tse nkang nakoana, e khothaletsoa bakeng sa kalafo ea bakuli ba nang le kotsi e eketsehileng ea hypoglycemia, mohlala, bakuli le bakuli ba nang le bothata ba ho lemala.
Kaha ho felisoa ha phekolo ea lera la Glyurenorm ho ke ke ha nahanoa, moriana o ka fuoa lingaka haholo-holo ho bakuli ba nang le bothata ba ho phekoloa ka methapo kapa lefu la tsoekere.
Ho sebetsa hantle le polokeho ea tšebeliso ea Glyurenorm ho bakuli ba nang le lefu la tsoekere ho netefalitsoe, e bontšitsoeng bakeng sa kalafo ka litokisetso tsa sulfonylurea tse nang le mafu a amanang le lefu la sebete.
Mofumahali Lihora tse 2-3 kamora ho kenella ka 30 mg ea Glurenorm, khatello e phahameng ea plasma e fihlelloa (500-700 ng / ml), e lateloa ke ho fokotseha hoa makhetlo a 2 ho lihora tse 1 / 2-1. sethethefatsi.
Glurenorm e amana ka mafolofolo le liprotheine tsa plasma (99%).
Glurenorm e na le metabolism e felletseng, haholo ke hydroxylation le demethylation. Boholo ba metabolites bo epolloa ka sistimi ea biliary e nang le makhopho. Ke karolo e nyane feela ea metabolites e epolloang ke liphio. Ke karolo ea 5% feela ea lethal dose e fumanoeng morohong. Le ka mor'a hore ho sebelisoe litekanyetso tse ngata tsa Glyrenorm, litlatsetso tsa phepo e ntse e le nyane.
Ntle le moo, ka tsamaiso ea kamehla ea Glyrenorm ho bakuli ba nang le lefu la tsoekere le lefu la tsoekere, ha ho liphetoho tse fumanoeng. Ha ho na kotsi ea ho bala ntho kapa metabolite ea eona.
Li-metabolites tsa mali ha li sebetse ka mokhoa oa meriana ebile ha li ame maemo a tsoekere ea mali.
Liteko tsa meriana mabapi le likhoto le litoeba li bonts'itse hore Glyrenorm le metabolites ea eona ha e tšele BBB kapa mokoallo oa placental.

Tšebeliso ea lithethefatsi Glyurenorm

Phekolo ea pele
Ka tloaelo, tekanyetso ea pele ea Glenrenorm ke Letlhare la 1/15 (15 mg). E nkuoa nakong ea lijo tsa hoseng. Ka ho se sebetse hantle, tekanyetso e ka eketseha butle-butle. Ntle le hore ha ho fanoe ka matlapa a fetang 2 (60 mg), tekanyetso ea letsatsi le letsatsi ea Glyurenorm e ka nooa hang nakong ea lijo tsa hoseng. Leha ho le joalo, ha e sebelisoa ka tekanyetso e phahameng, taolo e ntle ka ho fetisisa e fanoa ke makhetlo a 2-3 tekanyetso ea letsatsi le letsatsi. Tabeng ena, tekanyo e phahameng e lokela ho nkuoa ka nako ea lijo tsa hoseng. Matlapa a glenrenorm a tlameha ho nooa qalong ea lijo. Re lokela ho hlokomela hore ho eketsa tekanyetso ho lipilisi tse 4 (120 mg) ka letsatsi hangata ha ho lebise keketseho e 'ngoe ea phello ea kalafo.
Ha u nka moemeli e mong oa hypoglycemic ea molomo ka ts'ebetso e ts'oanang ea ts'ebetso
Tekanyetso ea pele e khethoa ho latela tsela eo lefu le leng ka eona ka nako ea tsamaiso ea moriana. Ha o kenya moemeli e mong oa antidiabetic le Glurenorm, ho lokela ho hopoloa hore ketso ea Letlapa le le leng la Glurenorm le batla le lekana le 1000 mg ea tolbutamide.
Pheko ea ho kopanya
Haeba monotherapy e nang le Glurenorm ha e fane ka taolo e lekaneng ea litekanyetso tsa tsoekere ea mali, ho tlameha ho nahanoa ka tumellano e eketsehileng ea biguanide.
Nako ea phekolo e itšetlehile ka mofuta oa lefu lena le katleho ea lona.

Contraindication mabapi le ts'ebeliso ea lithethefatsi Glurenorm

Mofuta o itšetlehileng ka insulin I lefu la tsoekere, lefu la tsoekere le lefu la tsoekere, lefu la tsoekere le thatafalloang ke acidosis le ketosis, kamora ho pancreatic resection, nakong ea lefu le tšoaetsanoang pele ho ts'ebetso ea ts'ebetso ea sebete, ho hloka matla ha sebete, ho kenella ka matla (hepatic) porphyria, hypersensitivity to litokisetso tsa sulfonylurea.

Litla-morao tsa lithethefatsi Glenrenorm

Ha e le molao, Glurenorm e mamelloa hantle ke bakuli, empa maemong a mang ho sisinyeha ha hypoglycemic, ho nyekeloa, ho nyekeloa, ho nyekeloa, lets'ollo, ho felloa ke takatso ea lijo, ho kulisoa ke tlala: ho hlohlona, eczema, ho opeloa ke hlooho, ho tsekela, ho sitisoa ha bolulo, thrombocytopenia ho ka hlaha.
Maemong a mang, intrahepatic cholestasis, urticaria, Stevens-Johnson syndrome, leukopenia, agranulocytosis li ka hlaha.

Litaelo tse khethehileng bakeng sa ts'ebeliso ea lithethefatsi Glurenorm

Nako ea bokhachane le pelehi. Boithuto ba ts'ebeliso ea Glyurenorm nakong ea bokhachane le lebactation ha bo so etsoa. Ka hona, ts'ebeliso ea Glurenorm e lokela ho qojoa nakong ena. Haeba ho ima ho thehiloe, ho bohlokoa ho emisa ho nka Glyurenorm kapele kamoo ho ka khonehang.
Ha ho phekoloa lefu la tsoekere, ho hlokahala tlhokomelo e tloaelehileng ea bongaka. Tlhokomelo e khethehileng e lokela ho nkuoa nakong ea khetho ea litheko kapa phetisetso ea lithethefatsi.
Le ha e le 5% feela ea Glurenorm e pepesitsoeng ke liphio 'me hangata e mamelloa hantle ho bakuli ba nang le lefu la liphio, kalafo ea bakuli ba nang le bothata bo matla ba ho phekola lefu la methapo e lokela ho etsoa tlasa tlhokomelo ea bongaka e haufi.
Bakuli ba nang le lefu la tsoekere ba tloaetse ho hola lefu la pelo le pelo. Kotsi ena e ka fokotsoa feela ka ho latela ka tieo lijo tse boletsoeng ke ngaka. Ts'ebeliso ea basebelisi ba lefu la tsoekere la molomo ha ea lokela ho nka sebaka sa phepo eu lumellang hore u laole boima ba 'mele oa mokuli mme e ea tlameha ho sa tsotelloe ts'ebeliso ea lithethefatsi tsa hypoglycemic. Lisebelisoa tsohle tse thibelang lefu la tsoekere ka sejo se sa reroang kapa ka tlolo ea mofuta oa moriana o khothalletsoang li ka lebisa ho fokotseha ho hoholo hoa maemo a tsoekere ea mali. Tšebeliso ea tsoekere, liswiti, kapa lino tse tsoekere hangata e thusa ho thibela boemo ba ho ba le tšoaetso ea pelehi.
Tšusumetso ho bokhoni ba ho khanna makoloi le ho sebetsa ka mekhoa e meng.Bakuli ba lokela ho lemosoa mabapi le ho latela mehato ea ho thibela hypoglycemia ha u ntse u khanna. Sena ke sa bohlokoa haholo ho ba se nang matšoao a hypoglycemia kapa ba tšoaeang liketsahalo tsa hypoglycemia khafetsa. Ho nepahala ha ho khanna ho lokela ho nahanoa ho latela maemo ana.

Ho sebelisana le lithethefatsi Glurenorm

Tšebelisano e ka bang teng le lithethefatsi tse amang metabolism ea glucose e lokela ho tsotelloa.
Meriana e ka ntlafatsang phello ea hypoglycemic ea Glurenorm: NSAIDs, MAO inhibitors, oxytetracyclines, ACE inhibitors, clofibrate, cyclophosphamides le li-derivatives tsa bona, sulfonamides le lithibela-mafu tse ling tse thibelang excretion, lithethefatsi tse ling tsa antidiabetes, insulin.
Meriana e ka etsahalang ho ntlafatsa phello ea hypoglycemic ea Glurenorm: li-blockers tsa β-adrenergic receptor, li-sensatholytics tse ling (mohlala, Clonidine), reserpine, guanethidine. Lintho tsena li ka koala matšoao a hypoglycemia.
Meriana e ka fokotsang phello ea hypoglycemic ea Glurenorm: GCS, lithibela-pelehi tsa steroid, sympathomimetics, lihomone tsa qoqotho, tsoekere, diuretics (mofuta oa thiazide kapa loop diuretics), diazoxide, phenothiazine, nicotinic acid.
Barbiturates, rifampicin, phenytoin le lintho tse tšoanang li ka fokotsa botebo ba phello ea hypoglycemic ea Glyrenorm ka ho tsosa li-enzyme tsa sebete.
Ho fokotseha kapa keketseho ea bophahamo ba phello ea hypoglycemic ea Glurenorm e bonoa ka tšebeliso e tšoanang le H2 receptor antagonists (cimetidine, ranitidine) le joala.

Sokolla foromo le sebopeho

Sebopeho sa litekanyetso tsa Glyurenorm ke matlapa: a chitja, a boreleli, a tšoeu, a entsoe ka thapo, ka lehlakoreng le leng ho na le mongolo oa letšoao la k'hamphani, ka lehlakoreng le leng ho na le kotsi, ka mahlakoreng ka bobeli ho na le mongolo o ngotsoeng "57C" (li-PC tse 10. Marang-rang a 12 ka har'a pakete ea karete.

Motsoako o sebetsang: glycidone, letlapeng le le leng - 30 mg.

Lintho tse ling: starch ea poone e qhibilihang, starch e omisitsoeng ea poone, furu ea magnesium, lactose monohydrate.

Mofumahali

Glycvidone e ntlafatsa tlhahiso ea insulin ka ho kenya ts'ebetsong tsela e pakeng tsa tsoekere bakeng sa tlhahiso ea ntho ena. Liteko tsa liphoofolo li paka hore lithethefatsi li fokotsa ho hanyetsa insulin ho lisele tsa adipose le lithane tsa sebete ka ho eketsa tumellano ea li-insulin receptors, hammoho le ho khothaletsa mochine oa post-receptor o bakoang ke insulin. Phello ea hypoglycemic e hlaha lihora tse 1-1,5 ka mor'a taolo ea molomo. Phello e phahameng e tlalehiloe lihora tse 2-3 kamora tsamaiso mme e nka lihora tse 8-10. Glycvidone ke sulfonylurea e nkang nakoana, e bakang ts'ebeliso ea eona ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 le kotsing e kholo ea ho etsa li-hypoglycemia, ho etsa mohlala, ho bakuli ba tsofetseng kapa bakuli ba nang le bothata ba ho hlaphoheloa kelellong.

Kaha glycidone e pepesoa ho liphio ka bongata bo bonyenyane, moriana o ka laeloa ho bakuli ba nang le lefu la tsoekere lephropathy le a sa sebetseng hantle. Ho na le bopaki ba hore ho nka Glenrenorm ho bakuli ba nang le lefu la tsoekere la mofuta oa 2, ba nang le mafu a sebete a amanang le lefu la tsoekere, ho sebetsa hantle ebile ho bolokehile. Leha ho le joalo, tlhahiso ea ntho e sebetsang ho bakuli ba joalo e thibetsoe. Tabeng ena, ho khethoa ha glycidone ho bakuli ba nang le lefu la tsoekere le rarahaneng le rarahaneng ha ho khothalletsoe.

Liphetho tsa lithuto tsa kliniki li tiisa hore ts'ebeliso ea Glyurenorm bakeng sa likhoeli tse 18 le tse 30 ha e bake keketseho ea boima ba 'mele,' me maemong a mang ho na le ho fokotseha ha boima ba 'mele ka kilo ea 1-2. Liphuputso tse bapisoang tseo ho tsona ho ithutoang tse ling tsa sulfonylurea li paka ho ba sieo ha liphetoho tse kholo tsa boima ba 'mele ho bakuli ba nkang glycidone.

Mofumahali

Ka ho kenella ka mokhoa o le mong oa glycidone ka tekanyo ea 15 kapa 30 mg, ntho ena e nkuoa ho tsoa mokokotlong oa lijo ka lebelo le phahameng mme e batla e le ka botlalo (80-95%). Palo e kholo ea bongata ba mali a methapo ea mali a 0,65 μg / ml (e fapana ho tloha ho 0.12 ho isa ho 2,14 μg / ml) mme e fihlella ka nako ea lihora tse 2 metsotso e 15 (ho fetoha hoa maemo ho 1,25-4.75 ho a khonahala dihora). Sebaka se tlasa khatello ea nako ea mahloriso (AUC) ke 5.1 μg × h / ml (ho fetoha hoa lipakeng tsa 1.5 le 10,1 μg × h / ml hoa khoneha).

Ha ho na phapang lipapaling tsa pharmacokinetic lipakeng tsa batho ba phetseng hantle le bakuli ba nang le lefu la tsoekere.

Glycvidone e tšoauoa ka tšebelisano e phahameng ea liprotheine tsa plasma tse fetang 99%. Tlhahisoleseling mabapi le ho kenella ha ntho kapa metabolites ea eona ka mali-boko le methapo ea placental ha e eo. Ha ho na bopaki bo fumanoeng ba hore glycidone e ka ba teng lebeseng la matsoele.

Glycvidone e na le metabolite e felletseng ka hara sebete, haholoholo ka demethylation le hydroxylation. Li-metabolites tsa Glycvidone ha li sebetse ka mokhoa oa meriana, kapa li bonts'a tšebetso e boletsoeng hanyane ka hanyane ha e bapisoa le karolo ea motsoali.

Li-metabolites tsa Glycvidone li hlahisoa ka bongata ka bongata, 'me ke a fokolang feela a bona a tsoang kahara moroto. Liphetho tsa lipatlisiso li bonts'a hore kamora taolo ea molomo, hoo e batlang e le 86% ea glycidone e epuoa ka popelong. Hoo e ka bang 5% (ka sebopeho sa metabolites) ea lethal dose e nkuoeng e hlahlojoa ka liphio, ts'ebetso ena ha e ts'ehe lipilisi ebile ha e ea its'etleha tseleng ea tsamaiso ea Glyrenorm. Le ha tšebeliso ea lithethefatsi e sebelisoa khafetsa, e tšeloa ka har'a moroto maemong a fokolang.

Ho felisoa ha halofo ea bophelo ke lihora tse 1,2 (bolelele ba phapang ke lihora tse 0,4-3), 'me pheletso ea bophelo ke lihora tse ka bang 8 (boleng bo ka fapana ho tloha lihora tse 5.7 ho isa ho 9.4).

Ho bakuli ba tsofetseng le ba lilemo tse bohareng, paramethara ea pharmacological e tšoana. Bakeng sa bakuli ba nang le bothata ba ho hlobaela ka mpeng le hepatic, bongata ba glycvidone bo hlohloreha mantle. Ho na le bopaki ba hore metabolism ea motsoako o sebetsang oa lithethefatsi e lula e sa fetohe ho bakuli ba nang le bothata ba sebete. Kaha glycidone e pepesoa lipelong ka tekanyo e nyane, ha ho na motsoako oa lithethefatsi ho bakuli ba nang le bothata ba ho hlaphoheloa kelellong.

Litaelo tsa ho sebelisa Glyurenorm: mokhoa le litekanyetso

Glurenorm e nkuoa ka molomo ho latela litlhahiso tsa ngaka mabapi le tekanyo le lijo.

Qalong ea kalafo, e le molao, matlapa a ½ a behiloe nakong ea lijo tsa hoseng (qalong ea lijo). Haeba ho se ntlafatso e hlokometsoeng, tekanyo eo e eketseha butle-butle.

Haeba tekanyetso ea letsatsi le letsatsi e sa fetele matlapa a mabeli, e lokela ho nooa tekong ea 1 hoseng. Haeba e feta, ho hlokahala hore o arole ka litekanyetso tse 2-3, empa nka karolo e kholo hoseng hoseng lijong tsa hoseng.

Sekhahla se phahameng se lumelletsoeng sa letsatsi le letsatsi ke matlapa a 4. Ho eketsa tekanyetso ea matlapa a fetang 4 ha ho na thuso, hobane ha ho lebise keketseho ea katleho.

Se ke oa tlola lijo ka mor'a ho nka Glyurenorm mme u khaotse ho sebelisa lithethefatsi ntle le ho buisana le ngaka.

Ha ho fanoa ka moriana oa moriana ka tekanyetso ea lipilisi tse fetang 75 mg (bakuli ba 2,5), bakuli ba nang le ts'oaetso ea sebete ba hloka ho lekola boemo ka hloko.

Tabeng ea phello e sa lekaneng ea kliniki nakong ea monotherapy le Glyrenorm, phekolo ea motsoako e kopaneng le metformin e ka ngolloa.

Litlamorao

Hematopoietic Sisteme: leukopenia, thrombocytopenia, agranulocytosis,
Tsamaiso ea methapo: ho otsela, vertigo, paresthesia, hlooho e bohloko, ho ikutloa o khathetse,
Sistimi ea methapo ea pelo: extrasystole, hypotension, angina pectoris, ho hloleha ha pelo,
Ts'ebetso ea ho ja: ho nyekeloa ke pelo, ho felloa ke takatso ea lijo, molomo o omileng, ho hloka botsitso ka mpeng, ho sokela / lets'ollo, ho hlatsa, cholestasis,
Metabolism: hypoglycemia,
Mokhatlo oa pono: likhathatso tsa sebaka sa bolulo,
Letlalo le mesifa e ikhethileng: karabelo ea photosensitivity, urticaria, rash, ho hlohlona, lefu la Stevens-Johnson,
Tse ling: bohloko ba sefuba.

Bongata

Tekanyetso e feteletseng ea Glyurenorm e ka tsosa hypoglycemia, e ikemiselitsoeng ke matšoao a latelang: ho tšoenyeha ka koloi, tachycardia, palpitations, puo e sa bonahaleng le pono, ho fufuleloa ka matla, tlala, ho akheha, ho hloka boroko, hlooho, ho thothomela le ho akheha. Ha matšoao a hypoglycemia a hlaha, ho hlokahala hore o je lijo tse nang le lik'habohaedreite tse ngata kapa tsoekere (dextrose).Haeba ho na le hypoglycemia e matla, e tsamaeang le ho akheha kapa ho akheha, dextrose e tsamaisoa ka matla. Kamora hore mokuli a hlaphoheloe kelellong, o lokela ho nka limatlafatsi tse tlotsitsoeng habonolo hore a qobe tlhaselo e pheta-phetoang ea "hypoglycemic".

Bokhachane le pelehi

Tlhahisoleseling mabapi le ts'ebeliso ea glycidone ho bakuli nakong ea bokhachane le lactation ha e fumanehe. Basali baimana ba fumanoeng ba tšoeroe ke lefu la tsoekere ba hloka ho lula ba shebile tsoekere ea plasma. Ho nka litlhare tsa hypoglycemic tsa molomo ho bakuli nakong ea kemaro ha ho tiise taolo e hlokahalang ea glycemic. Ka lebaka lena, ho nka Glyurenorm nakong ea kemolo ho hapuoe.

Haeba mokuli a imme nakong ea kalafo le moriana, kapa o o rerile, glycidone e hlakotsoe ebe e fetisetsoa ho insulin.

Ka ho se sebetse hantle ha sebete

Glurenorm ha e khothalletsoe ho bakuli ba nang le bothata ba ho hlobaela ka matla ho sebete, kaha 95% ea tekanyetso e nkuoeng e tšeloa ka har'a sebete 'me e hloekisoa ka mantle. Boithuto ba tsa bongaka moo bakuli ba nang le lefu la tsoekere le khatello ea methapo ea methapo ea methapo e amanang le khatello ea methapo e fapaneng (ho kenyeletsa le khatello ea maikutlo e matla ea sebete) le ho nka karolo ba bontšitse hore glycvidone ha e ea lebisa ho senyeha hoa ts'ebetso ea sebete, keketseho ea litla-morao, le litlamorao tsa hypoglycemic. ba ne ba le sieo.

Ho sebelisana le lithethefatsi

Hoa khoneha ho ntlafatsa phello ea hypoglycemic ea Glurenorm le ts'ebetso e ts'oanang ea lithethefatsi tse latelang: li-inhibitors tsa monoamine oxidase, lithethefatsi tse seng khahlanong le ts'oaetso ea li-insulin, li-analgesics, li-antifungal, li-antidepressants tsa triceclic, li-tetracyclines, insulin, lithethefatsi tse ling tsa molomo tsa hypoglycemic, angiotensin-cycloformin , sulfonamides, sulfinpyrazone, clofibrate, clarithromycin, chloramphenicol, allopurinol.

Sympatholytics (ho kenyelletsa clonidine), beta-blockers, guanethidine le reserpine ha e khone ho matlafatsa feela phello ea hypoglycemic ea Glyrenorm, empa ka nako e ts'oanang e pata matšoao a hypoglycemia.

Hoa khoneha ho fokotsa phello ea hypoglycemic ea Glyurenorm ha u ntse u fana ka litlhare tse latelang: sympathomimetics, glucocorticosteroids, lihormone tsa qoqotho, diazittics tsa looptiki, lithibela-pelehi tsa molomo, litokisetso tsa acid tsa nicotinic, aminoglutetimide, phenothiazine, diazoxide, glucagin.

Ka tšebeliso e tšoanang ea ethanol, histamine H blockers₂-receptors (ka mohlala, ranitidine, cimetidine), ho ka etsahala ka bobeli ho matlafatsa le ho fokolisa phello ea hypoglycemic ea Glyrenorm.

Litšoantšiso tsa Glurenorm ke: Amix, Glair, Glianov, Glibetic, Gliklada.

Sebopeho le mofuta oa tokollo

Glurenorm e fumaneha ka mokhoa oa litafole, tse tšoeu ka bophara tse nang le "57C" le letšoao la k'hamphani ka morao. Letlapa le leng le le leng le na le 30 mg ea ntho e sebetsang - glycidone, likarolo tse thusang li hlahisoa ka mokhoa oa: lactose monohydrate, starch ea poone e kolobisitsoeng, e omisitsoeng, le magnesium. Matlapa a tletse ka likotoana tse 10. ka marang-rang a kentsoeng ka har'a mabokose a 3, 6 kapa a 12 likhomphutha.

Tekanyetso le tsamaiso

Matlapa a nooa ka molomo. Mokhoa oa ho nka Glenrenorm le litekanyetso tsa lithethefatsi o thehiloe motheong oa metabolism ea carbohydrate.

Ka tloaelo, tekanyetso ea pele ea moriana ke halofo ea pilisi, ho khothalletsoa ho e nka lijong tsa hoseng. Ho feta moo, haeba ho hlokahala, tekanyetso e eketseha butle-butle (ho latela litlhahiso tsa ngaka).

Maemong moo mokuli a laetsoeng matlapa a mabeli ka letsatsi, a ka nooa hang. Litekanyetso tse phahameng tsa Glenrenorm e lokela ho aroloa ka tekanyetso e 'meli kapa e meraro.

Lipehelo le maemo a polokelo

Ho latela litaelo, Glurenorm e lokela ho bolokoa sebakeng se lefifi, se omileng le se sa fihleheng ho bana, ka mocheso oa kamore.

Ho tloha litlolong tsa litlama, lithethefatsi li fanoa ka taelo ea ngaka. Bophelo ba matlapa a matlapa, ho latela litlhahiso tsa moetsi, ke lilemo tse hlano. Glurenorm e ke ke ea sebelisoa kamora letsatsi la ho felloa ke nako.

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Ketso ea pharmacological

Glurenorm e baka pancreatic le extrapancreatic effect, e thusa ho tsosa sephiri sa insulin ea tlhaho (molaoli oa bohlokoa ka ho fetisisa oa metabolism ea carbohydrate) ka lisele tsa pancreatic beta, ha e ntse e ntlafatsa ts'ebetso ea insulin, e ama ho ts'oaroa ha glucose ka mesifa le sebete, hape e thibela lipolysis ho lithane tsa adipose. Khokahano ea tsoekere maling e qala ho fokotseha hora e le 'ngoe ka mor'a ho nka moriana, phello e phahameng e fihlella ka mor'a lihora tse 2-3, nako ea ketso ea Glenrenorm ho latela litlhahlobo ke lihora tse 8-10. Glurenorm e kenelletse ka botlalo ho tsoa ho tšilo ea lijo, e tšeloe ka har'a sebete 'me e hloekisoa haholo ka mala.

Glurenorm, kaha e tsoa ho sulfonylurea, ke lithethefatsi tse nkang nakoana, ka hona e khothalletsoa hore e sebelisoe ke bakuli ba nang le lefu la tsoekere la mofuta oa 2 ba nang le kotsi e kholo ea hypoglycemia (botsofe kapa mosebetsi o amanang le ho ruruha). Hape, lithethefatsi li ka sebelisoa ho bakuli ba nang le lefu la tsoekere le ho se sebetse hantle ha lefu la tsoekere, hobane glycidone e pepesetsoa ke liphio ka tekanyo e fokolang.

Contraindication Glenrenorm

Ho latela litaelo tse kentsoeng ho Glurenorm, ts'ebeliso ea lithethefatsi e patiloe ho:

Tšenyo e matla ea sebete,
Type 1 lefu la tsoekere
Lefu la tsoekere le boemo bo botle,
Linaha kamora ho pancreatic resection,
Mafu a tšoaetsanoang
Boimana le nako ea ho anyesa,
Ts'ebetso ea kalafo ka kalafo e hlokahalang ea insulin,
Galactosemia, khaello ea lactase,
Tlas'a lilemo tse 18,
Hypersensitivity ho lithethefatsi.

Hape, ka tlhokomeliso e fetelletseng, moriana o fuoa bakuli ba nang le ts'ebetso ea qoqotho e nang le bothata ba tšoelesa ea qoqotho, ea nang le febrile syndrome, hape le ba nang le joala.

Sebopeho sa moriana, litlhaloso tsa ona, sephutheloana, foromo

Litokisetso tsa Glurenorm li hlahisa mofuta o fe? Litaelo tsa ts'ebeliso li tsebisa hore sehlahisoa sena se fumaneha ka mokhoa oa matlapa a masoeu le a boreleli a sebopeho se chitja, a nang le mela ea senotlolo le tse betliloeng, hammoho le mongolo o ngotsoeng "57C" le "logo" ea k'hamphani.

Karolo e ka sehloohong ea lithethefatsi tseo ho buuoang ka tsona ke glycidone. E boetse e kenyelletsa starch e omisitsoeng ea poone, lactose monohydrate, starch ea poone e fumanehang le magnesium stearate (likhomphutha tse ling).

Moriana oa lithethefatsi (Glurenorm) o tsoela pele ho rekisoa ka lilakane tsa likotoana tse 10, tse nang le mekotla ea karete.

Ketso ea pharmacological

Moriana oa Glurenorm ke eng? Taeo ea ts'ebeliso e tlaleha hore ena ke moemeli oa hypoglycemic, derivative of sulfonylurea (moloko oa bobeli). E etselitsoe tsamaiso ea molomo feela.

Sesebelisoa se boletsoeng se na le litlamorao tsa extrapancreatic le pancreatic. E tsosa secretion ea insulin mme e baka tsela ea methapo ea glucose e bohareng ba eona.

Liteko mabapi le liphoofolo tse sebelisang laboratori li bonts'itse hore lithethefatsi "Glyurenorm", taelo ea eona e fumanehang ka lebokoseng la karete, li ka fokotsa ho hanyetsa insulin liseleng tsa adipose le sebete sa mokuli. Sena se etsahala ka ho hlohlelletsa mochine oa postreceptor, o kopantsoeng le insulin, hammoho le keketseho ea li-receptor tsa eona.

Phello ea hypoglycemic kamora ho sebelisa lithethefatsi e fetoha kamora metsotso e 65-95. Ha e le phello e phahameng ea lithethefatsi, e etsahala kamora lihora tse ka bang 2-3 mme e nka lihora tse ka bang 8-10.

Thepa ea Kinetic

Litaelo tsa ho sebelisoa "Glyurenorm" li re tšebeliso ea tekanyetso e le 'ngoe ea moriana ona (15-30 mg) e thusa ho nts'oa ha hae ka potlako le ka botlalo ho tsoa pampitšing ea mala (hoo e ka bang 80-95%). O fihla sehlohlolong sa mahloriso a hae kamora lihora tse peli.

Ntho e sebetsang ea lithethefatsi e na le tšebelisano e phahameng ea liprotheine tsa plasma.

Ha ho na data e fumanehang glycidon kapa lintho tse tsoang ho eona ka placenta kapa BBB. Hape ha ho na tlhahisoleseling mabapi le ho kenella ha glycidone ka lebese la matsoele.

Metabolism ea lithethefatsi "Glyurenorm" e hokae? Litaelo tsa tšebeliso li re moriana o ho buuoang ka ona o tšeloa ka har'a sebete ka demethylation le hydroxylation.

Bongata ba lintho tse tlosoang glycidone li epeloa ka mala. Bophelo ba halofo ea moriana ona ke lihora tse 1-2.

Ho bakuli ba tsofetseng le ba mahareng, li-paramente tsa kinetic tsa Glyurenorm lia tšoana.

Ho latela litsebi, metabolism ea sethethefatsi sena ha e fetohe ho bakuli ba nang le bothata ba sebete. Hape ho lokela ho hlokomeloe hore ho bakuli ba nang le bothata ba ho sebetsa ha renal ha bo bokellane.

Tlas'a lithethefatsi "Glurenorm" e sebetsa hantle ka tlasa maemo afe? Litaelo tsa tšebeliso, litekolo li fana ka maikutlo a hore pontšo ea tšebeliso ea eona ke mofuta oa 2 lefu la tsoekere ho batho ba tsofetseng le ba mahareng (ka ho se sebetse hantle hoa kalafo ea phepo).

Lithibelo tsa ho nka meriana

Ke maemong afe moo ho hateloang ho fana ka lipilisi tsa Glurenorm? Litaelo tsa ts'ebeliso li bonts'a litlolo tse latelang tsa moriana ona:

porphyria alternating acute,
Type 1 lefu la tsoekere
ho hloleha ho matla ha sebete,
lefu la tsoekere, thoroma, ketoacidosis le komisi,
nako kamora ho hlakoloa ha manyeme,
mafu a lefutsoang ka seoelo a kang galactosemia, ho se mamelle lactose, ho haella ha lactase le malabsorption ea glucose-galactose,
maemo a hlobaetsang a mokuli (mohlala, ho buoa ho tebileng, mafu a tšoaetsanoang),
nako ea kemaro
lilemo tse nyane (ka lebaka la datha tse sa lekanang mabapi le polokeho le katleho ea moriana sehlopheng sena sa lilemo),
nako ea ho anyesa
hypersensitivity ho sulfonamides.

Lithethefatsi "Glurenorm": litaelo tsa tšebeliso

Matlapa a glurenorm a beoa feela kahare. Ha u li nka, u lokela ho latela litlhahiso tsohle tsa ngaka mabapi le litekanyetso tsa moriana le lijo. Ho thibetsoe ho khaotsa ho sebelisa moriana ntle le ho buisana le setsebi pele.

Tekanyetso ea pele ea moriana o botsoang ke matlapa a 0,5 (i.e. 15 mg) nakong ea lijo tsa hoseng tsa pele. Moriana o lokela ho nooa qalong ea lijo. Kamora ho ja, ho tlōla lijo ha hoa lumelloa.

Haeba tšebeliso ea letlapa la 1/2 e sa bake ntlafatso, joale kamora ho buisana le ngaka, butle-butle litekanyetso li eketseha. Ka tekanyetso ea letsatsi le letsatsi ea "Glyurenorm" ha e fetise matlapa a 2, e ka nooa hang nakong ea lijo tsa hoseng.

Haeba ngaka e laetse litekanyetso tse phahameng tsa moriana, ka lebaka leo, litholoana tse ntle haholo li lokela ho aroloa ka litekanyetso tse 2 kapa tse 3.

Ho eketsa tekanyo ea litafole tse fetang tse 4 ka letsatsi hangata ha ho eketse katleho ea tsona. Ka hona, ho nka moriana "Glyurenorm" ka bongata bo fetang tekanyo e boletsoeng ha ho khothalletsoe.

Ho batho ba nang le bothata ba ho sebetsa ha renal, ho hloka phetoho ea litekanyetso ha e hlokahale.

Ho nka moriana o fetang 75 mg ho bakuli ba nang le ts'ebetso ea sebete e sa sebetseng ho hloka ho hlahlojoa khafetsa ke ngaka.

Mabakeng a kalafo e sa lekaneng ea kalafo, hammoho le "Glurenorm" mokuli a ka eketsoa ka mokhoa o "Metformin".

Maemo a overdose

Ho nka tekanyetso e phahameng ea litokollo tsa sulfonylurea hangata ho lebisa ho hypoglycemia. Ntle le moo, ho sebelisa lithethefatsi tse ngata ho feta tekano ho ka baka matšoao a latelang: ho fufuleloa, tachycardia, ho teneha, tlala, hlooho e bohloko, ho akheha, ho thothomela, ho hloka boroko, ho tšoenyeha ka koloi, ho sitoa ho bona hantle le ho bua.

Ha matšoao a hypoglycemia a hlaha, o lokela ho nka tsoekere kapa lijo tse nang le lik'habohaedreite tse ngata.

Litlamorao

Joale ua tseba hore na hobaneng ho fanoa ka lithethefatsi joalo ka Glurenorm. Litaelo tsa ho sebelisa meriana ena li boetse li hlahlojoa ka holimo.

Ho latela bakuli, ha u ntse u sebelisa moriana ona, o ka ba le:

thrombocytopenia, angina pectoris, agranulocytosis,
paresthesia, hypoglycemia, kizunguzungu,
leukopenia, hlooho e bohloko, extrasystole, boroko,
likhathatso tsa bolulo, mokhathala, hypotension,
ho se sebetse hantle ha pelo, molomo o omileng, lefu la Stevens-Johnson,
Takatso ea lijo e fokotsehile, ts'ebetso ea ho bona litšoantšo, ho nyekeloa, makhopho,
urticaria, ho hlatsa, bohloko ba sefuba, cholestasis,
ho sokela, ho hlohlona ha letlalo, lets'ollo, ho hlonama ka mpeng.

Ho sebelisana le lithethefatsi

Ka tsamaiso e tšoanang ea glycidone e nang le Allopurinol, li-inhibitors tsa ACE, lithethefatsi tsa antifungal, analgesics, li-coumarin derivatives, NSAIDs le ba bang, phello ea hypoglycemic ea pele e ka ntlafatsoa.

Rifampicin, barbiturates, hammoho le Phenytoin li fokotsa phello ea hypoglycemic ea Glyurenorm.

Litlhahiso tse khethehileng

Lisebelisoa tsa Hypoglycemic bakeng sa tsamaiso ea molomo ha lia lokela ho nka sebaka sa lijo tse phekolang.

Batho ba nang le lefu la tsoekere ba lokela ho latela ka tieo litlhahiso tsohle tsa ngaka.

Ha matšoao a hypoglycemia a hlaha, o lokela ho nka lijo tse nang le tsoekere hanghang.

Ho ikoetlisa ho ka ntlafatsa phello ea moriana.

Ka lebaka la hore tlhahiso ea "glycidone" ke liphio ha e na thuso, moriana o ka hlalosoang o ka bolokeha ho bakuli ba nang le bothata ba ho ruruha, hammoho le lefu la tsoekere.

Nakong ea lithuto tsa bongaka, ho ile ha fumaneha hore tšebeliso ea moriana o botsoang bakeng sa likhoeli tse 30 ha oa ka oa kenya letsoho keketseho ea boima ba mokuli. Ho feta moo, ho bile le maemo a ho fokotsa boima ba 'mele ka kilo ea 1-2.

Li-analog le tlhahlobo

Lithethefatsi tse latelang li fetisetsoa ho li-analogues tsa Glurenorm: Gliklada, Amiks, Glianov, Glayri, Glibetik.

Litlhahlobo mabapi le lithethefatsi tseo ho buuoang ka tsona li ka fumanoa li fapane haholo. Ho ea ka litlaleho tsa bareki, sethethefatsi sena se sebetsa haholo ebile se fumaneha ho motho e mong le e mong. Leha ho le joalo, ho lokela ho hlokomeloa hore bakuli ba bangata ba tšoenyehile haholo ka lethathamo la karabelo e bohloko ea tharollo ena. Leha lingaka li bolela hore li na le seoelo ebile li maemong a itseng feela.