Tsifran OD > Phekolo le thibelo

Tsifran OD e fumaneha ka mofuta oa matlapa a nkang nako e telele, a koahetsoeng ka filimi: ho tloha ho o mosoeu ho ea ho o mosoeu, oval, ka har'a membrane ea filimi ho na le mongolo o ngotsoeng ka enke ea lijo tse ntšo "Cifran OD 500 mg" kapa "Cifran OD 1000 mg" (li-pcs tse 5. , ka lebokoseng la mekotla e le 'ngoe ea 2 kapa 2,.

Letlapa le le leng le na le:

ntho e sebetsang: ciprofloxacin - 500 mg kapa 1000 mg,
likarolo tse thusang: sodium bicarbonate, sodium alginate (Kelton LVCR), crospovidone (Kollidon CLM), hydroxypropyl methylcellulose, magnesium stearate, aerosil 200, talc,
sebopeho sa sheath: Opadry 31В58910 tšoeu (lactose monohydrate, hypromellose, macrogol 400, titanium dioxide), talc, hydroxypropyl methylcellulose, metsi a hloekisitsoeng.

Mofumahali

Tsifran OD ke lithethefatsi tse thibelang likokoana-hloko. Mokhoa oa ts'ebetso ea ona o bakoa ke ts'ebetso ea bactericidal ea ciprofloxacin (fluoroquinolone), e sitisang ts'ebetso ea topoisomerase II, enzyme e hlokahalang bakeng sa phetisetso e tloaelehileng ea DNA ea baktheria (deoxyribonucleic acid). Ho ba sieo ha topoisomerase ts'ebetsong ea biochemical ho baka tlolo ea motsoako oa liprotheine tse tloaelehileng ho libaktheria.

Ciprofloxacin e sebetsa khahlano le mefuta e mengata ea libaktheria tse latelang:

Gram-positive aerobic: Listeria monocytogenes, Bacillus anthracis, Enterococcus faecalis (sensitivity amanang le boholo ba mathata), Streptococcus pyogene, Staphylococcus epermidis, Staphylococcus aureus (methicillin e hlokahallang le e hlahisang penicillococcus, e ts'oarelletsang makhopho, a ho loants'oa batho ba bang.
Gram-negative aerobic: Citrobacter diversus, Campylobacter jejuni, Citrobacter freundii, Escherichia coli, Enterobacter cloacae, Moraxella catarrhalis, Haemophilus parainfluenzae, Haemophilus influenzae, Klebsiella pneumoniae, Morganella gerogoromererg , Shigella boydii, Shigella flexneri, Shigella dysenteriae, Shigella sonnei, Salmonella typhi.

In vitro, ciprofloxacin ka tekanyo e fokolang ea inhibitory (MIC) ea 0.001 mg / ml e sebetsa khahlanong le ho feta 90% ea mathata a likokoana-hloko tse latelang (katleho ea tleliniki ea ketsahalo ena ha e so ka e hlalosoa):

aerobic gram e ntle: Staphylococcus haemophilus, Staphylococcus hominis,
Gram-negative aerobic: Edwardsiella tarda, Aeromonas hydrophila, Acinetobacter lwoffii, Brucella melitensis, Salmonella enterit>

Ho hanyetsa ciprofloxacin ho bonahatsoa ke: Burkholderia cepacia (boholo ba lintho), Stenotrophomonas maltophilia (likarolo tse ling), Bacteroides fragilis, Clostridium Hardile le libaktheria tse ling tsa anaerobic.

Mofumahali

Kamora ho tsamaisoa ka molomo, ho kenngoa ha ciprofloxacin ho tsoa pampiring ea mokokotlo ho etsahala ka potlako. Ts'oarelo ea nako e telele ea koprofloxacin e tiisa ts'ebetso ea tlhokomelo ea eona e hlokahalang kahare ho plasma ea mali ha e nka Cifran OD 1 nako ka letsatsi.

Tlhokahalo e phahameng (C_max) ntho e sebetsang ka plasma ea mali e fihlelloa ka lihora tse 6 mme e ka ba 0,0013 mg / ml ka mor'a tekanyetso e le 'ngoe ea li-cyfran OD 500 mg le lipilisi tsa 0.0024 mg / ml - Tsifran OD 1000 mg. Khatello ea plasma ka kakaretso (AUC) ea ciprofloxacin ntlheng ena e tsamaellana le hoo e ka bang 0.0083 le 0.0189 mg / ml / h.

Ka liprotheine tsa mali tsa mali li tlama 20-40%.

Ciprofloxacin e kenella habonolo metsing a 'mele le liseleng. E fumanoa manonyeletsong, secretion ea mucous membrane ea nko le bronchi, lymph, fluid fluid, semen le secretion ea tšoelesa ea senya. E ajoa mats'oafong, letlalong, mesifa, adipose, lefufuru le lisele tsa masapo, tšoelesa ea senya.

Sebeteng, ciprofloxacin e tšeloa metsoako e itseng.

T_1/2 (halofo ea bophelo) - lihora tse 3.5-4,5.

Hoo e ka bang 50% ea lethal dose le nkoang ka molomo e pepesoa lipelong ha e sa fetoloe, e ka bang 15% ka sebopeho sa metabolites e sebetsang. Hoo e ka bang 35% ea lethal dose e fumanoe ho potoloha ha mali.

Ka ho hloleha ho matla ha renal le ho batho ba baholo, T_1/2 e kanna ea eketsoa, ka hona, moriana oa litekanyetso o tlameha ho fetoloa ho nahanisisa ka tumello ea creatinine (CC) ea mokuli.

Ka mokhoa o tsitsitseng oa cirrhosis, pharmacokinetics ea ciprofloxacin ha e fetohe haholo. Ho lokela hore ho sebelisoe tlhokomeliso ka ho hloleha ha sebete haholo ka lebaka la khaello ea data ho kinetics ea ntho e sebetsang.

Matšoao a ho sebelisoa

Ho latela litaelo, Tsifran OD e bontšoa bakeng sa kalafo ea mafu a tšoaetsanoang le a tšoaetsanoang a bakoang ke likokoana-hloko tse qalang:

pneumonia, ho mpefatsa ha bronchitis e sa foleng, mathata a tšoaetsanoang a cystic fibrosis le mafu a mang a tšoaetsanoang a tsamaiso e tlase ea phefumoloho ea etiology e tšoaetsanoang,
sinusitis e matla
cystitis, pyelonephritis (ho kenyelletsa le mefuta e rarahaneng),
gonorrhea
baktheria e sa foleng ea baktheria
cholecystitis, cholangitis, empyma ea gallbladder, peritonitis, mala a ka mpeng a tsoang ka mpeng le mafu a mang a ka mpeng - hammoho le metronidazole,
mafu a letlalo
mofuta o hlobaetsang le o sa foleng oa osteomyelitis le mafu a mang a tšoaetsanoang a manonyeletso le masapo,
anthrax,
lets'ollo le hlahileng (ho kenyeletsa "lets'ollo la baeti"),
feberu ea typhoid.

Contraindication

ho se sebetse hantle ha renal (ka tlase ho 29 ml / min, ho kenyelletsa bakuli ba hemodialysis),
pseudomembranous colitis,
Phekolo e kopanetsoeng le tizanidine,
lilemo tse 18
nako ea kemaro
sefuba
hypersensitivity ho lithethefatsi tsa sehlopha sa fluoroquinolone,
ho se mamellane ha motho ka mong likarolo tsa moriana.

Ka tlhokomeliso, ho hlokahala ho fana ka ts'ebeliso ea Tsifran OD ka ho hloleha ho matla ha sebete, ho se sebetse hantle ha mokokotlo ka CC ea 35-50 ml / min, kotsi ea lefu la mokokotlo, lefu le matla la mokokotlo, lefu la kelello, lefu la sethoathoa, tšenyo ea tendon nakong ea kalafo e fetileng le fluoroquinolones, botsofaling.

Litaelo tsa ts'ebeliso ea Tsifran OD: mokhoa le litekanyetso

Matlapa a Cifran OD a nooa ka molomo, ka mor'a ho ja, ho metsa ka botlalo (ntle le ho senya membrane) le ho noa metsi a mangata.

Mokuli o nka tekanyetso e boletsoeng 1 nako ka letsatsi.

Tekanyetso e khothalletsoang ea Tsifran OD:

tšoaetso ea mafu a tšoaetsanoang le a tšoaetsanoang ea likarolo tse tlase tsa sistimi ea ho hema: boima bo bonolo le bo leka-lekaneng - 1 g bakeng sa matsatsi a 7-14, mefuta e matla le e rarahaneng - 1.5 g bakeng sa matsatsi a 7-14,
sinusitis e mpe haholo: bonolo ho isa tekanyong e matla - 1 g bakeng sa matsatsi a 10,
ts'oaetso ea pampitšana ea urinary: foromo e sa rarahanang - 0.5 g bakeng sa matsatsi a 3, ho teba le ho teba - 0.5 g bakeng sa matsatsi a 7-14, mefuta e matla le e rarahaneng - 1 g bakeng sa 7 -14 matsatsi
gonorrhea: foromo e sa sebetseng hantle - 0.5 g bakeng sa letsatsi le le leng, e rarahaneng - 0.5 g bakeng sa matsatsi a 3-5,
bakteria e sa foleng ea baktheria: ho teba le ho leka-lekana - 1 g e ngoe le e ngoe, nako ea kalafo ke matsatsi a 28,
ts'oaetso ea intraperitoneal (hammoho le metronidazole): mefuta e rarahaneng - 1 g bakeng sa matsatsi a 7-14,
mafu a tšoaetsanoang a letlalo: ho teba le ho leka-lekana - 1 g bakeng sa matsatsi a 7-14, mefuta e matla le e rarahaneng ea ts'oaetso - 1.5 g, kalafo - matsatsi a 7-14,
mafu a tšoaetsanoang a manonyeletso le masapo: ho teba le ho leka-lekana - 1 g bakeng sa matsatsi a 28-25, mefuta e matla le e rarahaneng - 1.5 g bakeng sa matsatsi a 28-25 kapa ho feta,
letšollo ea etiology e tšoaetsanoang: bonolo, e leka-lekaneng kapa e matla - 1 g bakeng sa matsatsi a 5-7,
feberu ea typhoid: bohale bo bonolo, bo itekanetseng - 1 g bakeng sa matsatsi a 10,
anthrax (thibelo le kalafo): 1 g e 'ngoe le e' ngoe, nako e telele - matsatsi a 60.

Ho amoheloa ha litlolo tsena ho lokela ho tsoelapele ka matsatsi a mabeli kamora ho nyamela ka botlalo matšoao a lefu lena.

Ka ho se sebetse hantle hantle, ho lokisoa kalafo ea litekanyetso tsa Tsifran OD e etsoa ho tsotelloa QC ea mokuli ka tatellano e latelang:

QC e kaholimo ho 50 ml / min: tekanyetso e tloaelehileng,
KK 30-50 ml / metsotso: 0.5-1 g ka letsatsi,
QC 5-29 ml / min, bakuli ba nang le hemodialysis kapa peritoneal dialysis: ts'ebeliso ha e khothalletsoe.

Bakeng sa banna, QC e ka khethoa ka ho ngatafatsa boima ba 'mele (kg) ka phapang e fumanoeng kamora ho tlosa ho tloha ho lilemo tsa hae tsa bo-140 lilemong. Sephetho se arotsoe ke sehlahisoa - palo e fumanoeng ka ho eketseha ha 72 ke khatello ea creatinine maling a mali (mg / dl).

Bakeng sa basali, QC e tsamaellana le letšoao le baliloeng ho latela sesebelisoa sa banna, mme ho eketsoa ka lebaka la 0.85.

Ho bakuli ba tsofetseng, ho khethoa ha fluoroquinolones ho lokela ho etsoa ho nahanisisa ka ho fokotseha ho amanang le lilemo ho amanang le ts'ebetso ea liphio.

Litlamorao

ho tloha tsamaisong ea methapo ea kutlo: Photophobia, ho hloka boroko, ho teneha, ho opeloa ke hlooho, ho tsekela, ho eketseha ha mokhathala, ho opeloa ke boroko, ho tšoenyeha, ho thothomela, pherekano, ho holofala ha litho tsa moea (khatello ea maikutlo), khatello ea maikutlo, khatello e matla ea ho kenella kahare, ho lematsa mahlo, ho akheha, lipontšo karabelo ea kelello (ho kenyeletsa le ho intša kotsi), lefu la mokokotlo oa mokokotlo,
ho tsoa liphoofolong tsa kutlo: kutloisiso e senyehileng ea monko le tatso, diplopia, kutlo ea kutlo, tinnitus,
ho tsoa ho ts'ilo ea lijo: ho ruruha, bohloko ba ka mpeng, ho nyekeloa, ho hlatsa, ho ipolaea, letšollo, hepatitis, choleundatic jaundice (hangata e khahlano le semelo sa mafu a sebete a nakong e fetileng), hepatonecrosis,
Tsamaisong ea pelo le methapo ea pelo: ho fokotsa khatello ea mali (BP), tachycardia, ho fifatsa sefahleho, litšitiso tsa morethetho oa pelo,
ho tsoa ho hematopoietic system: leukopenia, granulocytopenia, eosinophilia, anemia, thrombocytopenia, hemolytic anemia, leukocytosis, thrombocytosis,
ho tsoa ho ts'ebetso ea urine: ho boloka urine, hematuria, dysuria, polyuria, crystalluria (hangata khahlano le semelo sa karabelo ea alkaline ea moroto, tlhahiso e tlase ea mokokotlo), lefu la sethoathoa sa methapo ea methapo, albinuria, glomerulonephritis.
Tsamaisong ea 'mele ea ho itšireletsa mafung: ho hlohlona letlalo, feberu ea lithethefatsi, urticaria, petechiae, blistering (ho kenyelletsa ho tsoa mali), ponahalo ea maqhubu a manyane a etsang lekhalo, ho hema hanyane, ho ruruha ha sefahleho le / kapa larynx, erythema nodosum, vasculitis, erythema multiforme, chefo e matla ea morao ea ho senya (lefu la Lyell), erythema e kotsi (Stevens-Johnson syndrome),
ho tsoa ho tsamaiso ea musculoskeletal: ramatiki, tenosynovitis, arthralgia, myalgia, tendon ruptures,
paramente ea laboratori: hypercreatininemia, hypoprothrombinemia, hyperglycemia, ts'ebetso e eketsehileng ea hepatic transaminases, hyperbilirubinemia, ts'ebetso e eketsehileng ea lactate dehydrogenase le alkaline phosphatase,
ba bang: bofokoli bo akaretsang, ho fufuleloa ho feteletseng, pseudomembranous colitis, candidiasis, photosensitivity.

Bongata

Mats'oao: Litla-morao tse nang le chefo.

Phekolo: ha ho na litlhare tse tobileng. Ntlheng ena, ho potlakile ho susumetsa ho hlatsa kapa ho hlatsoa mpa. E latelang ke ho khethoa ha kalafo ea matšoao, ho kenyelletsa infusions le mehato e meng bakeng sa hydration e lekaneng, kalafo ea tlhokomelo. Ts'ebeliso ea hemo- le peritoneal dialysis ha e na thuso; ho fihlela ho 10% ea tekanyetso e amoheloang ea ciprofloxacin e ka tlosoa.

Litaelo tse khethehileng

Ka lebaka la kotsi ea karabelo ea photosensitivity e amanang le ts'ebeliso ea fluoroquinolones, ho pepesetsoa mahlaseli a matla a kotsi a matla ho kenyelletsa le khanya ea letsatsi e tobileng, ho lokela ho qojoa nakong ea kalafo. Haeba ts'ebetso ea photosensitivity e etsahala, matlapa a lokela ho emisoa.

Ha ho fumanoa sesosa sa lets'ollo le matla le le nako e telele le bileng teng nakong ea kalafo le Cifran OD, nts'etsopele ea "pseudomembranous colitis" e lokela ho nahanoa. Haeba pseudomembranous colitis e tiisitsoe, ho tlosoa ha moriana hanghang le ho khethoa ha kalafo e nepahetseng hoa hlokahala.

Ho thibela nts'etsopele ea "crystalluria" nakong ea ho nka litafole, hoa hlokahala ho noa metsi a lekaneng, ho boloka motsoako oa acidic le ho thibela tekanyetso ea litekanyetso tsa letsatsi le letsatsi tsa moriana.

Kaha ka nalane ea lesapo la mokokotlo oa organic, mafu a methapo ea methapo, lefu la sethoathoa, kapa ho ts'oaroa, ciprofloxacin e baka nts'etsopele ea litla-morao tse tsoang tsamaisong ea methapo, bakuli ba nang le li-pathologies tsena ba ka fuoa Tsifran OD feela ka mabaka a bophelo bo botle.

Bakuli ba lokela ho tsebisoa ka tlhokahalo ea ho tlohela moriana hang-hang ha ho e-na le bohloko ka har'a tendon le matšoao a pele a tenosynovitis.

Foromo ea litekanyetso

Matlapa a koahetsoeng ka filimi ka tokollo e tsitsitseng ea 500 mg le 1000 mg

Letlapa le leng le na le

ntho e sebetsang - ciprofloxacin 500 mg le 1000 mg

intragranate: sodium alginate, hypromellose, sodium bicarbonate, crospovidone, magnesium stearate,

eketsehileng: magnesium e bohale, talc e hloekisitsoeng, silicon dioxide colloidal anhydrous,

khetlaempa: Opadry 31V58910 tšoeu (hypromellose, lactose monohydrate, titanium dioxide (E171), macrogol 400, hypromellose, talc e hloekisitsoeng,

inkOpacodeS-1-17823 (Ntsho): glossy shellac, joala ba isopropyl, ferric oxide / ferric oxide e ntso (E 172), butyl alcohol, propylene glycol, 28% ammonia solution.

Matlapa a nang le sebopeho sa oval a kopantsoeng le filimi a koahelang ho tloha ho tšoeu ho isa ho a masoeu, a neng a ngotsoe "Cifran OD 500 MG" ka enke ka lehlakoreng le leng. Bolelele 17.1  0,1 mm, bophara ba 8.1  0,1 mm, botenya ba 5.6, 0,3 mm (bakeng sa litekanyetso tsa 500 mg).

Matlapa a nang le sebopeho sa oval, a kopantsoeng le filimi e koahelang ho tloha ho tšoeu ho isa ho e tšoeu, 'me ho ngotsoe "Cifran OD 1000 MG" ka enke ka lehlakoreng le leng. Bolelele 21.2  0,1 limilimithara, bophara 10,6  0,1 limilimithara, bophara 7.6  0,3 limilimithara (bakeng sa litekanyetso li-1000 mg).

Ho sebelisana le lithethefatsi

Ka tšebeliso e tšoanang ea Tsifran OD:

metronidazole, beta-lactams, clindamycin, aminoglycosides le tse ling tse antimicrobials: baka synergism. Bakeng sa kalafo e atlehileng ea ts'oaetso e bakiloeng ke li-specseles tsa Pseudomonas, motsoako le ceftazidime le azlocillin, ts'oaetso ea lefutso la lefu la tsoekere le lithibela-mafu tsa beta-lactam (meslocillin, azlocillin), ts'oaetso ea staphylococcal le vancomycin, isoxazolpenicillin ts'oaetso, anaerobic aminerocytamines, anaerobic aminerocytamines
theophylline: e eketsa bongata ba mali a mali,
tizanidine: e eketsa kotsi ea ho fokotseha hoa khatello ea mali, ponahalo ea ho otsela,
litlhare tsa immunosuppression le antitumor: fokotsa ho amoheloa ha Cyfran OD ha ho nooa ka molomo,
didanosine: e thusa ho fokotsa ho monya ha ciprofloxacin,
li-antacid tse kenyelletsang aluminium kapa magnesium hydroxide ka sebopeho: kenya letsoho ho fokotseheng ha monko oa ciprofloxacin, ka hona motsoako ona oa hanyetsoa,
Lithethefatsi tse thibelang secretion ea tubular, ho kenyelletsa le phenenecid: fokotsa phokotseho ea renal ea ciprofloxacin,
analgesics: baka litlamorao tse matla tsa ciprofloxacin e tsoang tsamaisong ea methapo e bohareng,
phenytoin: e ka fokotseha kapa ea eketsa khatello ea hau ea plasma,
sucralfate: e fokotsa ho amoheloa ha Cyfran OD,
bahanyetsi ba H₂- Li-receptor tsa histamine: ha ho na phello e kholo lithutong ka bioavailability ea ciprofloxacin,
anticoagulants ea molomo, ho kenyelletsa warfarin le lintho tse tsoang ho eona: ntlafatsa ts'ebetso ea bona, ka hona, ha e kopantsoe le moriana, lithuto tse tloaelehileng tsa mokhoa oa ho kopanya mali li hlokahala,
glyburide: e ka baka hypoglycemia e matla,
baemeli ba hypoglycemic ea molomo, caffeine le li-xanthine tse ling: eketsa boemo ba bona ba khatello le ho holisa T_1/2,
metoclopramide: e potlakisa ho monya,
li-uricosuric agents: hoo e ka bang 50% e liehisa ho felisoa ha ciprofloxacin, e bakang keketseho ea plasma ea eona,
cyclosporine: e matlafatsa sephetho sa eona sa nephrotoxic. Kaha ho na le keketseho ea serum creatinine, boemo ba eona bo tlameha ho laoloa makhetlo a 2 ka beke.

Litšoantšiso tsa Cifran OD ke: Cifran, Ciprofloxacin, Vero-Ciprofloxacin, Ifippro, Quintor, Basigen, Betaciprol, Nircip, Procipro, Ciprinol, Ciprobay, Ciprolaker, Cipromed, Ciprofloxabol, Ciploxinal, Ciprox.

Melemo ea pharmacological

Licrofloxacin litafole tse tsitsitseng tsa tokollo li etselitsoe ho lokolla sethethefatsi ka tekanyo e tlase ha li bapisoa le matlapa a ho lokolla kapele.

Pale ea pharmacokinetic ea ciprofloxacin litafole tse lokolotsoeng tsa 1000 mg hang ka letsatsi e bapisoa le boemo ba matlapa a 500 mg a profrofloxacin ka tokollo e potlakileng habeli ka letsatsi, ho latela Auc e ka bapisoang le nako ea lihora tse 24.

Kamora ho tsamaisoa ka molomo, ciprofloxacin e kenella ka potlako haholo ka popelong e nyane. Khokahano e phahameng ea ciprofloxacin ho serum e fihlella ka mor'a lihora tse 1-2. Bioavailability e batla e le 70-80%. Boleng ba khatello e kholo ea plasma (Cmax) le sebaka se katlase ho "curve" nako "(AUC) li eketseha ka tekanyo ea tekanyetso.

Khokahano ea ciprofloxacin le liprotheine tsa plasma ke 20-30%, ntho e sebetsang e teng ka har'a plasma ea mali haholo ka sebopeho se sa hlahisoang. Ciprofloxacin e tsamaisoa ka bolokolohi liseleng le maro a 'mele. Bophahamo ba karolelano ea 'mele ke 2-3 l / kg. Khetla ea ciprofloxacin liseleng e phahame haholo ho feta ho ts'oaroa ke serame sa mali.

Biotransformed ka har'a sebete. Li-metabolite tse 'ne tsa profrofloxacin ka har'a lintho tse nyane li ka bonoa maling: diethylcycrofloxacin (Ml), sulfociprofloxacin (M2), oxociprofloxacin (MZ), formylcycrofloxacin (M4), tse tharo tseo (M1-MZ) li bonts'ang ts'oaetso ea antibacteria e ka bapisoang le ts'oaetso ea anti-anti-antibacteria. acid. Ts'ebetso ea antibacterial ho vitro ea M4 metabolite, e teng ka tekanyo e nyane, e tsamaisana haholo le ts'ebetso ea Norfloxacin.

Ciprofloxacin e hloekisoa haholo ke liphio ka ho hlohlona ha glomerular le secretion ea tubular, e nyane ka pampitšana ea ka mpeng. Mofuta oa morara o hlaha nakong ea lihora tse 24 kamora ho sebelisa moriana. Ho tloha ho 1 ho isa ho 2% ea tekanyetso e nkuoeng e chekoa ka mokhoa oa metabolites o nang le bile, hoo e ka bang 20-35% ea moriana o qheleloa ka har'a mantle nakong ea matsatsi a 5 kamora ho busa. Serum halofo ea bophelo ba bakuli ba nang le ts'ebetso e tloaelehileng ea renal ke lihora tse ka bang 7.

Litlhahlobo tsa Pharmacokinetic tsa litafole tsa molomo tse tsoang kapele (tekanyetso e le 'ngoe) le lifrofloxacin bakeng sa tsamaiso ea methapo ea methapo (tekanyetso e le' ngoe le e mengata) li bonts'a hore lintlha tsa plasma tsa ciprofloxacin li phahame ho batho ba baholo (ba fetang 65) ha ba bapisoa le batho ba baholo ba baholo. Cmax e nyoloha ho tloha ho 16% ho isa ho 40%, mme AUC e tloaelehileng e nyoloha ka hoo e ka bang 30%, e ka bang bonyane ka lebaka la ho fokotseha ha tumello ea ho ba le repholo ho batho ba tsofetseng. Halofo ea bophelo e phela hanyane hanyane feela ho batho ba baholo (

20%). Liphapang tsena ha li na bohlokoa ba bokuli.

Ho bakuli ba nang le bothata ba ho sebetsa ha renal, nako ea bophelo ea ciprofloxacin e kanna ea eketsoa. Phetoho ea mori ha e hlokehe ho bakuli ba nang le ts'oaetso ea pampiri e bonolo ea moroto e amohelang foromo ea litekanyetso tsa 500 mg e tsitsitseng. Bakeng sa ts'oaetso e rarahaneng ea tšebeliso ea moroto le pyelonephritis e boima, moo ho sebelisoang lethal la 1000 mg, litekanyetso tsa ciprofloxacin tse nang le ketso ea nako e telele li lokela ho fokotsoa ho 500 mg hang ka letsatsi.

Thutong ea bakuli ba nang le "cirrhosis" e sa foleng ea sebete, ha ho liphetoho tse kholo tsa pharmacokinetics tsa ciprofloxacin. Ka nako e ts'oanang, kinetics ea ciprofloxacin ho bakuli ba nang le bothata ba ho se sebetse hantle ha sebete e tsebahala ka mokhoa o sa lekaneng.

Ciprofloxacin ke setlhare sa antibacterial se entsoeng ka mokhoa o pharaletseng oa sehlopha sa fluoroquinolones.

Ciprofloxacin e na le ts'ebetso ea vitro khahlano le mefuta e mengata ea likokoana-hloko tse mpe tsa gram tse mpe. Ketso ea bactericidal ea ciprofloxacin e etsoa ke mofuta o thibelang libaktheria tsa mofuta oa II (topoisomerase II (DNA gyrase) le topoisomerase IV), tse hlokahalang bakeng sa ho pheta, ho ngola, ho lokisa le ho pheta-pheta DNA ea baktheria.

Khanyetso ea in vitro ea ciprofloxacin hangata e bakoa ke liphetoho tse hlahisang motsoako oa kokoana-hloko ea baktheria le li-gyrase tsa DNA 'me li tsoela pele butle butle ka lebaka la liphetoho tse ling tse ngata.

Phetoho e le 'ngoe e ka lebisang ho fokotseheng ha kutloelo-bohloko ho feta ho nts'etsopele ea khatello ea bongaka, leha ho le joalo, liphetoho tse ngata li lebisa ho nts'etsopele ea ho hanyetsa ha kliniki ho ciprofloxacin le ho hanana le lithethefatsi tsa quinolone. Ho hanyetsa ciprofloxacin, joalo ka lithibela-mafu tse ling tse ngata, e ka etsoa ka lebaka la ho fokotseha ha boteng ba sele ea baktheria (joalo ka ha ho le joalo le ka Pseudomonas aeruginosa) le / kapa ts'ebetso ea ho tlosoa hoa leseli le tsoang ho microbial cell (efflux). Ho boleloa nts'etsopele ea ho hanyetsa ka lebaka la mofuta oa "cn" oa Qnr o fumanehang sebakeng sa plasmids. Mekhoa ea ho hanyetsa e lebisang ho inactivation ea penicillin, cephalosporins, amino glycosides, macrolides le tetracyclines mohlomong ha e sitise mosebetsi oa antibacterial oa ciprofloxacin. Likokoana-hloko tse loantšang lithethefatsi tsena li kanna tsa ameha ka ciprofloxacin. Tekanyetso e tlase ea bactericidal (MBC) hangata ha e fetise bonyane ba "inhibitory" (MIC) ka makhetlo a fetang a mabeli.

Ho hanyetsa sefapano. Ho hanyetsa pakeng tsa ciprofloxacin le li-antimicrobial agents tsa litlelase tse ling ha ho bonoe.

Ciprofloxacin e sebetsa khahlano le mefuta e mengata ea libaktheria tse latelang maemong in vitro, le ts'ebetsong ea bongaka ea ho phekola tšoaetso.

Aerobic Gram-Positive Microorganisms : Bacillus anthracis, Staphylococcus aureus (methicillin-sens Staphylococcus saprophyticus, Streptococcus spp.Likokoana-hloko tse mpe tsa aerobic gram-negative : Aeromonas spp., Moraxella catarrhalis, Brucella spp., Neisseria meningitidis, Citrobacter koseri, Pasteurella spp., Francisella tularensi, Salmonella spp., Haemophilus ducreyi, Shigella spp, Haemophilius influenzae, Vibri. Legri.Likokoana-hloko tsa Anaerobic : Mobiluncus spp .

Likokoana-hloko tse ling : Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma hominis, Mycoplasma pneumoniae. Tekanyo e fapaneng ea ho ba le kutloisiso ho ciprofloxacin e bontšitsoe bakeng sa likokoana-hloko tse latelang: Acinetobacter baumann, Burkholderia cepacia, Campylobacter spp. Pseudomonas fluorescens, Serratia marcescens, Streptococcus pneumoniae, Peptostreptococcus spp., Propionibacterium acnes. Ho lumeloa hore ciprofloxacin ka tlhaho e hana. Staphylococcus aureus (methicillin-thibela) Stenotrophomonas maltophilia, Actinomyces spp., Enteroccus faecium, Listeria monocytogene, Mycoplasma genitalium, Ureaplasma urealitycum, likokoana-hloko tsa anaerobic (ntle le Mobiluncus spp., Peptostreptococus spp., Propionibacterium acnes) .

Litlhahlobo mabapi le Tsifran OD

Tlhahlobo ea Tsifran OD e ntle, e bontša ts'ebetso e phahameng ea bongaka kalafong ea mafu a mangata a baktheria.

Bakuli ba tlaleha mamello e ntle ea Cifran OD, ho se be teng ha litlamorao tse boletsoeng, ho qala ka potlako ho bohloko bo boholo.

Tekanyetso le tsamaiso

Matlapa a tlameha ho metsoa ntle le ho hlafuna, a hohotsoe ka metsi. Li ka nooa ho sa tsotelehe nako ea lijo. Ha e nkoa ka mpeng e se nang letho, ntho e sebetsang e kenella ka potlako.

Matlapa a Cifran OD a nooa hang ka letsatsi.

Tekanyo le mokhoa oa kalafo o itšetlehile ka lipontšo, botebo le ho hlaka ha ts'oaetso, ts'ebetso ea ts'oaetso ea li-pathogenic microorganism (ciphogenicacin), ts'ebetso ea pheko ea bakuli, le ts'ebetsong ea bongaka le ea baktheria.

Bakeng sa kalafo ea tšoaetso e itseng ea baktheria (k.j. Pseudomonas aeruginosa, Acinetobacter kapa Staphylococci) e ka hloka litekanyetso tse phahameng tsa ciprofloxacin le tsamaiso ea tšebelisano-'moho le baemeli ba bang ba loketseng li-antibacterial.

Bakeng sa kalafo ea tšoaetso e itseng (jk. Mafu a ho ruruha ha litho tsa kahare, mahlaba a ka mpeng, ts'oaetso ho bakuli ba neutropenic, le tšoaetso ea masapo le manonyeletso), ho sebelisana 'moho le li-antibacterial tse ling ho ka hlokahala ho latela lipeo tsa mafu tse amehang.

Nako ea kalafo (ho kenyelletsa kalafo ea pele ea botsoali ka ciprofloxacin)

Tšoaetso e tlase ea phefumoloho

Mafu a tšoaetsanoang ka ho fetesisa a phefumoloho

Ho eketseha ha sinusitis e sa foleng

1000 mg - 1500 mg

Ramatiki e sa feleng ea tšehetso ea maikutlo

1000 mg - 1500 mg

Malignant otitis externa

Matsatsi a 28 ho isa ho likhoeli tse 3

Tšoaetso ea pampitšana ea urinary

500 mg - 1000 mg

Ho basali ba lilemo tsa premenopausal, 500 mg (lethal dose le le leng)

Cystitis e rarahaneng, pyelonephritis e sa rarahanang

1000 mg -1500 mg

bonyane matsatsi a 10, a ka nka nako e fetang matsatsi a 21 bakeng sa ts'oaetso e itseng e matla (mohlala, li-abscesses)

Libeke tse 2 ho isa ho tse 4 (a hlobaetsang) libeke tse 4 ho isa ho tse 6 (tse sa foleng)

Tšoaetso ea pampitšana ea genital

Gonococcal urethritis le cervicitis

500 mg (tekanyetso e le 'ngoe)

Letsatsi le le leng (tekanyetso e le 'ngoe)

Orchoepididymitis le mafu a tšoaetsanoang a litho tsa kahare

1000 mg -1500 mg

bonyane matsatsi a 14

Ts'oaetso ea ka mpeng le tšoaetso ea methapo

Letšollo le bakoang ke likokoana-hloko tsa baktheria, incl. Shigella spp., ntle le mofuta oa 1 Shigella dysenteriae le kalafo e matlafatsang ea baeti ba matla ba lets'ollo

Type 1 lets'ollo Shigella dysenteriae

Letsatsi la ho felloa ke nako:

Maemo a phomolo:
E lokolloa ka lengolo la ngaka.

Setifikeiti sa ho ingolisa
Ranbaxy Laboratories Limited / Ranbaxy Laboratories Limited
Sahibzada Ajit Singh Nagar (Mohali) - 160055, (Punjab), India / Sahibzada
Ajit Singh Nagar (Mohali) - 160055, (Punjub), India
Likopo tsa bareki li lokela ho romelloa ofising ea baemeli ea Ranbaxi
Laboratories Limited atereseng: 129223, Moscow, Prospect Mira, Setsi sohle sa Russia sa Lipontšo, Setsi sa Khoebo Technopark, moaho 537/4, ofisi 45-48.

Moetsi
Ranbaxi Laboratories Limited, Paonta Sahib, Dist. Sirmur 173025, Himachal Pradesh, India.
Ranbaxy Laboratories Limited, Paonta Sahib, Dist. Sirmour 173025, Himachal Pradesh, India.

Tsifran ST ke eng

Ho latela sehlopha sa tsa bongaka le tsa meriana, Tsifran ST ke ea sehlopha sa li-antimicrobials (lithibela-mafu) tse tsoang sehlopheng sa fluoroquinolones. Moriana o sebopeho sa litafole o etsoa ke k'hamphani ea India. Likhetho tsa CT tsa cyfran 250 mg le 500 mg lia fumaneha. Li rekisoa ka lebokoseng la karete ea karete, matlapa a moqhobong o betliloeng o entsoeng ka foil ea aluminium, litaelo tsa tšebeliso li hlile lia eketsoa. Matlapa a na le 'mala o mosehla, o mosehla mmala, o koahetsoeng ka filimi.

Ntho e sebetsang

Cifran ST e na le metsoako e 'meli e sebetsang - 250 kapa 500 mg ea ciprofloxacin hydrochloride le 300 kapa 600 mg ea tinidazole. Ba ananeloang ke microcrystalline cellulose, colloidal anhydrous silicon magnesium stearate, sodium starch glycolate, sodium lauryl sulfate. Karolo e ka ntle ea matlapa e na le sodium starch glycolate, talc e hloekisitsoeng, sodium lauryl sulfate, cellulose ea microcrystalline, colloidal anhydrous silicon, le magnesium stearate. Khetla e na le metsi a hloekisitsoeng, opadra e tšehla.

Koprofloxacin

Ho hatella li-enzyme tse hlokahalang bakeng sa kholo ea libaktheria, ciprofloxacin e eketsoa ho lithethefatsi tsa antimicrobial ST Cifran. E thibela metabolism e tloaelehileng ea moemeli oa causative oa lefu lena, e na le phello ea bactericidal liseleng tse phomolong. Ntho ena e amehile ka libaktheria tse seng ntle le gram le likokoana-hloko tse ntle tsa gram - tsena ke enterobacteria, morganella, chlamydia. Ciprofloxacin e kenella ka seleng, e thibela likokoana-hloko tse hlahisang beta-lactamase.

Derivative ea nitroimidazole ke karolo ea cyphran ST, e sebetsang khahlanong le anaerobes le protozoa. Tinidazole e ea sebetsa, e kenella ka har'a lisele, e senya DNA ea baktheria kapa e thibela motsoako oa eona. E hatella clostridia, peptococci, gardnerella, fusobacteria le mafu a mang a amanang le anaerobic haholo. Ts'ebeliso ea tinidazole e sebetsa khahlano le anaerobes e bonolo le e tlamang.

Ho tloha litafoleng Tsifran ST

Letlapa le leng le le leng la matlapa le na le likotoana tse 10 kapa tse 100 tse nang le litaelo tsa ho li sebelisa. Tsifran ST e sebetsa ho mafu afe?

sinusitis e sa foleng
lesapo la matšoafo
empyema
osteomyelitis e sa foleng,
liso tsa lefu la tsoekere
liso tsa khatello
periodontitis, periostitis, maloetse a mang a meno
Ciprofloxacin e ka phekola lets'ollo, 'mele oa ka mpeng kapa' mala o kopaneng.

Mokhoa oa ketso

Tsifran e lokiselitsoeng ho loants'oa lithethefatsi ka motsoako o kopaneng bakeng sa kalafo ea ts'oaetso e kopaneng e bakoang ke anaerobes le aerobes, mafu a tšoaetsanoang a lesapo la mokokotlo. Ho kopana ha tinidazole le ciprofloxacin ho ama mefuta e meng ea likokoana-hloko ka bobeli, ho fa motsoako o mongata ts'ebetso. Lintho tsena ka bobeli li kenelletse hantle ka har'a tšilong ea lijo, li fihlella lintho tse phahameng ka mor'a lihora tse 'maloa.

Boaoavailability ea tinidazole ke 100%, protheine ea plasma e 12%. Setlama se kopaneng se kenella ka potlako linthong tse ling, se fihlela likhahla tse phahameng. Tinidazole e fumanoa mokelikeli oa "cerebrospinal fluid", moriana o tšeloa ka har'a moroto le makhopho. Ciprofloxacin e kenella ka mor'a ts'ebeliso, bioavailability ea eona ke 70%. 30% e 'ngoe e amana le liprotheine tse mahlorisong a plasma. Ntho ena e kenella matšoafong, letlalo, mafura, mesifa, lefufuru, masapo.

Tsifran ST lithibela-mafu - litaelo tsa ho sebelisoa

Sehlahisoa sa motsoako oa antimicrobial se rekisoa litlhare tsa meriana, se bolokiloeng ka mocheso ho fihlela likhato tse 25 sebakeng se omileng, se hloekileng, moo bana ba ke keng ba se fihlela. Bophelo ba Shelf ke lilemo tse 2. Litaelo tsa ST Tsifran tse sebelisoang li na le litaelo tse ikhethang:

se ke oa ngolla bakuli ba ka tlase ho lilemo tse 12,
ha e sebelisoe ka mor'a letsatsi la ho felloa ke nako,
ha e kopantsoe le li-anticoagulants tse sa tobang li ntlafatsa tšebetso ea tsona le ketso ea ethanol,
e sebetsa le sulfonamides, lithibela-mafu, empa ha e lumellane le ethionamide,
ha e kopantsoe le phenobarbital e potlakisa metabolism,
tšebeliso e kopaneng e eketsa khatello ea theophylline, li-coagulants tse sa tobang, li fokotsa index ea prothrombin,
Cifran e nang le prefix ST e ntlafatsa chefo ea cyclosporin, e eketsa serum creatinine,
Ho sebelisoa ka nako e le 'ngoe le lithethefatsi tse seng khahlanong le' mele tse sirelletsang mali ho eketsa kotsi ea ho ts'oaroa,
ha u ntse u nka litafole, qoba ho pepesetsoa letsatsi haholo ho qoba tšenyo ea maikutlo.
ha e tsamaellane le joala - ho na le bohloko, mala, mpeng, ho nyekeloa,
e ama lebelo la karabelo, ka hona e hanetsoe ha u khanna, o etsa mosebetsi o kotsi,
tšebeliso ea moriana ka mabaka a bophelo bo botle o laeloa ho bakuli ba nang le lefu la ho akheha, ho tsitsipana, maloetse a methapo le bokong, mafu a methapo ea kutlo
ho nka moriana ho emisoa haeba ho e-na le lets'ollo le matla le sa feleng, bohloko ba tendon, ponahatso ea tendovaginitis,
nakong ea kalafo e thibelang likokoana-hloko, lingaka li lekola boemo ba lipalo tsa mali tse potileng.

Lokolla liforomo le sebopeho

Moriana o fumaneha ka mokhoa oa matlapa. Li koahetsoe ka membrane ea filimi, e na le sebopeho sa oval le mmala o mosoeu.

Motsoako o na le 1000 mg ea motsoako o sebetsang, o sebelisitsoeng ciprofloxacin. Litokisetso li na le likarolo tse thusang:

crospovidone
shellac
hypromellose,
talcum phofo
isopropanol
oxide e ntšo ea tšepe
silika
ammonia e metsi
sodium bicarbonate,
sodium alginate
propylene glycol
magnesium stearate.

Moriana o fumaneha ka mokhoa oa matlapa. Li koahetsoe ka membrane ea filimi, e na le sebopeho sa oval le mmala o mosoeu.

Ketso ea pharmacological

Sesebelisoa se na le phello ea bactericidal. Moriana ona ha o sebetse khahlano le likokoana-hloko feela empa o boetse o na le mefuta e fapaneng ea libaktheria tse maemong a khutsitseng.

Tsifran e loketse ho felisa mafu a bakoang ke ketsahalo ea microflora e seng ntle le gram.

Ho thusang

Sesebelisoa se thusa ho loants'a mafu a latelang:

sinusitis e matla
ho ruruha lesapo la senya (cystitis),
mofuta oa tšoaetso oa lets'ollo,
peritonitis
ts'ebetso ea ho ruruha e hlophisitsoeng sebakeng se kahara gallbladder,
senya ho renal tubules (pyelonephritis),
ho mpefala ha bronchitis e sa foleng,
baktheria e sa foleng ea baktheria
ho ruruha ha methapo ea bile,
gonorrhea
pneumonia
feberu ea typhoid
methapo ea masapo le manonyeletso, ho kenyelletsa osteomyelitis e mpe le e sa foleng,
mafu a tšoaetsanoang a letlalo.

Tsifran OD eu lumella ho sebetsana ka katleho le ho ruruha ha lesapo la senya (cystitis).

Ka tlhokomelo

Hoa hlokahala ho ela hloko mathata a latelang le li-pathologies:

ho hloleha ha sebete
cerebral arteriosulinosis le mathata ka phepelo ea mali ho setho,
Tšenyo ea tendon e hlahisoang ke kalafo e sebelisang lithethefatsi tsa fluoroquinolone,
mathata a kelello
lefu la sethoathoa
ho se sebetse hantle ha sebete,
ho hloleha ha rems.

Maemong ana, lithethefatsi li fanoa ka hloko.

U ka nka Cifran OD joang?

Moriana ona o sebelisoa ka nako e le 'ngoe ka letsatsi, ke lihora tse ling le tse ling tse 24.

Setlhare se lokela ho nooa ka molomo, se hlatsoa letlapa ka khalase ea metsi a hloekileng.

Setlhare se lokela ho nooa ka molomo, se hlatsoa letlapa ka khalase ea metsi a hloekileng. Ngaka e sebetsana le dosing, hobane ha ho fanoa ka moriana, motho o lokela ho nahana ka lilemo, boemo ba mokuli le sethala sa kholo ea kholo ea methapo.

Nako ea kalafo e khethoa ho na le ho teba ha lefu lena. Ho lokela ho hopoloa hore nako ea kalafo e lokela ho tsoela pele matsatsi a mang a mabeli kamora ho nyamela hoa matšoao.

Ho nka moriana oa lefu la tsoekere

Nakong ea nts'etsopele ea lefu la tsoekere mellitus, moriana o sebelisoa ho latela litaelo. Pele u qala ho sebelisa meriana ena, o hloka ho buisana le setsebi.

Nakong ea nts'etsopele ea lefu la tsoekere mellitus, moriana o sebelisoa ho latela litaelo.

Phekolo ea ka mpeng

Ho tsoa ho tšilo ea lijo, matšoao a latelang a ka hlaha:

cholestatic jaundice
lesapo la mokokotlo,
ho theola boima ba 'mele
lets'ollo
botlaela
hepatitis
bohloko bo ka mpeng
ho hlatsa le ho nyekeloa.

Ho tloha ka mpeng ho na le litla-morao tse ka hlahisang e le ho hlatsa le ho khothaletsa ho nyekeloa hoa pelo.

Hematopoietic litho tsa ka hare

Litlamorao tse latelang li ka hlaha ho litho tsa hemopoietic:

hemolytic mofuta anemia,
palo e ngata ea liplatele maling.
palo ea lisele tse tšoeu tsa mali,
ho fokotsa palo
granulocytopenia,
leukopenia
liphetoho lipalo tsa eosinophils.

Tsamaiso ea methapo e bohareng

Matšoao a latelang a hlaha:

hlooho, ho kenyeletsa migraine,
maemo a ho akheha
ho tšaba leseli
thothomela
boikutlo ba ho tšoenyeha
ho se khonehe
khathatso ea boroko
ho tsekela
Kameho e sa utloahaleng ea bohloko,
bosiu
mokhathala,
maemo a sithabetsang
hallucinations.

Ho nka Tsifran OD ho ka baka lihlooho, ho kenyelletsa le migraines.

Ho tsoa ts'ebetsong ea moroto

Litla-morao tse tsoang tsamaisong ea urine li bontšoa ke matšoao a latelang:

ho bolokoa ka moroto
ho tsoa mali, ho kenyelletsoa nakong ea mickey
tlhahiso ea moroto o boima
tlolo ea ts'ebetso ea ho ntša metsi,
senya ho glomeruli ea renal,
secretion ea protheine ka moroto.

Ho tsoa ho tsamaiso ea methapo ea pelo

Moriana o ka ama hampe tsamaiso ea methapo ea pelo, ka lebaka leo lipontšo tse latelang li etsahala:

phallo ea mali sefahlehong,
sekhahla sa pelo
khatello e fokotsehileng
phetoho ea methapo ea methapo ea pelo.

Moriana o ka ama hampe tsamaiso ea pelo le pelo, oa baka khatello e tlase ea mali.

Ha u ntse u sebelisa lithethefatsi, u ka fumana matšoao a latelang a ho kula.

se etsahalang letlalong: lithutsoana, ho hlohlona, urticaria,
Lefu la Lyell, le emeloang ke lekhopho, makhopho a nang le metso ea serous, lera la letlalo,
ho hema hanyane
li-nodule tse nyane tsa scaba
hemorrhages,
feberu ea tšimoloho ea lingaka,
ho ruruha ha lekhalo le sefahleho,
ho ruruha ha letlalo le li-membrane tsa mucous, tse lebisang ho qalweng ha erythema e mpe.

Tekanyo ea joala

Ho nwa joala nakong ea kalafo ho ka lematsa sebete le litho tse ling, hobane setlhare ha se tsamaisane hantle le joala.

Sebelisa botsofaling

Moriana o kopantsoe le pheko ho bakuli ba tsofetseng.

Nako ea ho beleha ngoana ke ho qhekella ka ho nka meriana.
Moriana o fetela ka lebeseng la matsoele, ka hona, ho sebelisa sehlahisoa, ngoana o lokela ho fetisetsoa mofuteng oa lijo kapa a khetha setlhare se fapaneng.
Nako ea lilemo tse 18 ke contraindication, ka hona Cifran ha e sebelisoe ho bana.
Moriana o kopantsoe le pheko ho bakuli ba tsofetseng.

Mokhoa oa ho noa Tsifran

Matlapa a moriana oa antibacterial Cifran o nang le prefix ST a nooa ka molomo kamora lijo. Li lokela ho hlatsuoa ka metsi a lekaneng a sa khabisitsoeng ka carbon - ka khalase. Ha ho kgothaletswe ho roba letlapa. Bakuli ba hloka ho bona hore na ba nooe meriana joang, ba qoba ho sebelisa moriana o fetang tekano o nang le mathata a mangata a fetang ha meriana e felisitsoe.

Ho latela litaelo tsa Tsifran ST, sethethefatsi sena se sebelisoa kamora lijo le metsi a lekaneng. Motsoako o khothalletsoang oa letsatsi le letsatsi bakeng sa batho ba baholo ba kaholimo ho lilemo tse 18 ke matlapa a mabeli habeli ka letsatsi (sethethefatsi se nang le koprofloxacin le tinidazole 250/300 mg) kapa pilisi e le 'ngoe habeli ka letsatsi e nang le litekanyetso tsa li-ingredient tse sebetsang tsa 500/600 mg. Tsela ea kalafo e itšetlehile ka ho teba ha lefu lena le lintlha tsa kliniki le tsa baktheria.

Bonyane matsatsi a mararo a tsoelepele ho phekola kamora ho feberu ha feberu, 'me bolelele bo tla ba:

letsatsi le gonorrhea e boima,
Likhoeling tse peli le osteomyelitis,
bonyane matsatsi a 10 moo ho nang le streptococci le chlamydia,
ka lebaka la bokhoni ba ho inkela matlapa ka mokhoa oa molomo, mokuli o fumana tharollo ea ho kenella ka metsing ka moriring.

Nka nka cyfran nakong ea kemolo?

Ha ho kgothaletswe ho fana ka ts'ebeliso ea CT ea Tsifran nakong ea kemolo, hobane tinidazole e na le phello ea carcinogenic le mutagenic, mme ciprofloxacin e tšela placenta mme e ama nts'etsopele ea lesea. Lintho tse ka bobeli li sebetsang li fumanoa ka lebeseng la mosali nakong ea pelehi, ka hona ho se ke ha khothalletsoa letsoele. CT Digital ha e laeloe ho anyesa. U hloka ho emisa ho anyesa kapa ho khetha kalafo e 'ngoe.

Likarolo tsa tšebeliso bongoaneng

Litaelo tsa ho sebelisoa ha ST Tsifran li re ha e lumelloe bana ba ka tlase ho lilemo tse 18, empa e lumelloa ho sebelisa lithethefatsi bakeng sa mathata a bakoang ke baktheria, a nang le pulmonary cystic fibrosis. Ebe ngoana ea lilemo li 5-17 a ka nooa moriana o thibelang likokoana-hloko, ntho e 'ngoe e ikhethang ke ho thibela le ho phekola lefu la sethoathoa sa pulmonary. Ha ho na datha thutong ea mofuta oa mofuta oa litekanyetso ho bana ba nang le ho hloleha ha hepatic le renal.

Matlapa a Cifran a fokolisang sebete le tšebetso ea a liphio

Ka tlhokomeliso, ho kgothaletswa ho nka Tsifran ka prefix ST bakeng sa batho ba nang le bohloko bo matla ba ho renal le hepatic, hammoho le bakuli ba tsofetseng. Bakeng sa bakuli ba joalo, lethal dose le fokotseha halofo, 'me ngaka e eang e e shebelletse nakong eohle ea kalafo. Hoa hlokahala hore kamehla u hlahlobe boemo ba sebete le liphio, setšoantšo sa mali, ho kheloha hanyane ka hanyane ho tloaelehileng.

Litla-morao le li-contraindication

Litaelo tsa ho sebelisa lithethefatsi tse antibacterial ST Tsifran li bonts'a litlolo tse latelang:

hypersensitivity reaction or lintlha tse ka ho kopanya lintho tsohle tse amanang le lithethefatsi,
nalane ea maloetse a hematologic,
contraindicated ho bakuli ba thibelo ea masapo a hematopoiesis, a nang le phello e matla ea porphyria,
allergy
liso tsa methapo
liso tsa manyolo
bana ba ka tlase ho lilemo tse 18,
ka tlhokomeliso ho ts'oaetso ea methapo ea methapo, kotsi ea methapo, bokuli ba kelello, lefu la sethoathoa.

Liphetoho tse mpe tse tsoang ho ho nka li-antibiotic tsa Cifran ke lintho tse latelang tse sa thabiseng tse tsoang litsamaisong tse ling tsa 'mele:

ho felloa ke takatso ea lijo, ho hlatsa, lets'ollo, "cholentatic jaundice" (joalo ka setšoantšo))
hlooho e opang, ho tsekela, ho tepella ho hoholo, neuropathy, cramps, dysarthria, ho thothomela, ho hloka boroko,
khatello e kenelletseng ea ho kena-kenana, khatello ea maikutlo, pherekano, thrombosis, ho akheha, migraines, hallucinations,
pono e fokotsehileng, bofokoli ba kutlo,
tachycardia, ho hloleha ha morethetho oa pelo, khatello e tlase ea mali,
leukopenia anemia, thrombocytopenia, anemia,
hematuria, polyuria, mokokotlo oa ho ntša metsi, nephritis, dysuria, qoba crystalluria,
pruritus, urticaria e akaretsang, scabs, hemorrhages,
arthralgia, ramatiki, tendovaginitis, asthenia, myalgia, candidiasis, colitis, ropo ea tendon.

Ke bokae

K'holejeng ka k'hemisteng ea inthanete ka ho tsamaisoa kapa ho reka ka pharmacist ho ka nka matlapa a Tsifran. Ha u reka Moscow le St. Petersburg, o ka khetha bongata ba metsoako e sebetsang ea lithethefatsi. Kahoo, matlapa a 10 a 500 + 600 mg a tla bitsa li-ruble tse 357, le 250 + 300 mg ka tekanyo e le 'ngoe - li-ruble tse 151. Marang-rang, litšenyehelo tsena li fokotsoa ka 10%, empa ho eketsoa litšenyehelo tsa ho tsamaisoa ke motsamaisi.

Ka dintho tse sebetsang, ts'ebetso ea bongaka le litšobotsi tsa bophelo, analogue ea Tsifran ST, e hlahisoang ke likhoebo tsa India le tsa malapeng, e khetholloa:

Tsiprolet, Tsipro-TK, Tsifomed-TZ, Grandazole, Zoksan-TZ, Zoloxacin, Orzipol, Ofor, Polymik, Tiflok, Roksin, Yetat,
Tharollo ea tlhahiso ea Grandazole
phofo bakeng sa tharollo ea Norzidime,
Cephoral, Quintor, Tsiprobay.

Maxim, ea lilemo li 23, Tsifran ST o ile a re ke laetsoe ke ngaka kamora ho fumana periodontitis. Ke ile ka nka phekolo ea lithibela-mafu mme ka hlokomela ntlafatso - marenene a emisa ho lla, ho ruruha ho ile ha qala ho fela, ho ka etsahala ho tsoela pele kalafo le ho beha moqhaka. Setlhare se seholo sa tekanyetso!

Nina, ea lilemo li 30. Ka mor'a ho nka leeto leetong, ke ile ka tšoaroa ke lets'ollo. Ho ne ho le hobe haholo, ngaka e ile ea laela meriana e thibelang likokoana-hloko hore e fole kapele. O ile a mpeheletse litekanyetso tse phahameng tsa Tsifran, le meriana e meng. Re ile ra khona ho felisa lefu lena ka beke.

Ho sebelisana le lithethefatsi tse ling

Tsifran e khetholloa ke likarolo tse latelang tsa tšebelisano le meriana e meng:

Fokotsa ho monya ha ntho e sebetsang ha u sebelisa li-antacids moo ho nang le aluminium hydroxide kapa magnesium hydroxide.
Keketseho ea phallo ea lithethefatsi tse fokotsang tsoekere, li-anticoagulants, xanthines le Theophylline.
Ho amoheloa ha ciprofloxacin ka mokhoa o theohileng nakong ea tšebeliso ea didanosine.
Ponahalo ea ho otsela le ho fokotseha ho hoholo ha khatello ka lebaka la ts'ebeliso ea tizanidine.
Keketseho ea menyetla ea ho ba le litla-morao ha u ntse u nka litlhare tse se nang tšebeliso ea mali le li-analgesics.
Phokotso ea serum phenytoin e theohileng.
Keketseho ea litlamorao tse mpe holima liphio nakong ea kalafo le Cyclosporine.
Keketseho ea katleho ha e sebelisoa hammoho le metronidazole, clindamycin le aminoglycosides.
Ho fokotsa ho tlosoa hoa 'mele le ho eketsa motsoako oa motsoako o sebetsang ha u sebelisa lithethefatsi tsa uricosuric.
Ho kenngoa ka sekhahla ha Cyfran ka lebaka la ts'ebeliso ea metoclopramide.

Kamohelo ea Tsifran OD e tšoauoa ka keketseho ea menyetla ea ho ba le litla-morao ha a ntse a nka lithethefatsi tse seng tsa antiidalidal le antigesics.

Liphetoho tsa lithethefatsi li kenyeletsa:

Ciprobay ke setlhare se entsoeng ka Sejeremane se nang le 250 kapa 500 mg ea ciprofloxacin.
Litafole tsa Ciprinol tse nang le phello ea antibacterial.
Siflox ke lithethefatsi tse nang le litlamorao tse ngata tse fapaneng tsa bactericidal.
Taba ke moemeli oa antibacterial moo ntho e sebetsang e leng hemifloxacin mesylate.
Leflobact ke sethethefatsi se bolaeang likokoana-hloko se nang le 250 kapa 500 mg ea levofloxacin hemihydrate. Lithethefatsi li loana ka katleho le chlamydia, staphylococci, ureaplasma, legionella, enterococci le likokoana-hloko tse mpe tsa gram.
Gatifloxacin ke moemeli oa antibacterial o tsoang sehlopheng sa fluoroquinolones. Ke ea moloko oa 4.
Cifran ST ke lithethefatsi tse bolaeang likokoana-hloko tse nang le 500 mg ea ciprofloxacin le 600 mg ea tinidazole. E fumaneha India. E sebelisoa e le uroanaseptic ho gynecology, hammoho le ho meno, otolaryngology le likarolo tse ling tsa meriana.

Phapang ke efe pakeng tsa Tsifran le Tsifran OD

Ho ikhetholla ha Cifran OD ho amana le phello e phahameng, e fokotsang khafetsa taolo ea lithethefatsi.

Tlhahlobo ea lingaka le bakuli ka Tsifran OD

Evgeny Alexandrovich, ngaka e akaretsang

Ts'ebeliso ea Cifran OD e thusa ho sebetsana le mafu a tšoaetsanoang haholo, hobane libaktheria tse ngata li tsotella ciprofloxacin. Moriana o tšoauoa ka ho pepesetsoa nako e telele, o nang le phello e ntle boleng ba kalafo.

Irina, ea lilemo li 41, Togliatti

Ka lebaka la ts'oaetso e bonolo ea lefu la tsoekere ho lefu la tsoekere, Cifran o laetsoe. Moriana o thusitse ka matsatsi a 'maloa ho fokotsa matšoao le matla a ho ruruha. Phekolo e 'ngoe e ile ea etsoa sepetlele hobane ho ne ho hlokahala tlhokomelo ea bongaka. Ntho feela e ka khahlang moriana ke boholo ba matlapa, ka hona ho thata ho a metsa.

Elena, ea lilemo li 39, Irkutsk

Ka thuso ea Tsifran, OD e ile ea tlosa ts'oaetso. Leha ho le joalo, kalafo e ne e thatafatsoa ke litla-morao, tseo ho tsona ho neng ho e-na le tse ngata. Kamora ho nka letlapa la pele, bohloko bo ile ba hlaha molomong, ka lebaka leo lijo li fetohile liteko. Hamorao ho ile ha hlaha tsietsing, ho nyefola le ho nyekeloa hoa pelo. Setlhare sena sea sebetsa, empa ka lebaka la litla-morao tse joalo, ke tla hana ho sebelisa sehlahisoa nako e tlang.

Tšusumetso ho bokhoni ba ho khanna makoloi le mekhoa e rarahaneng

Nakong eohle ea kalafo, o ke ke oa kenya letsoho ts'ebetsong ea ts'ebetso ea mesebetsi e ka bang kotsi, ho kenyelletsa taolo ea lipalangoang, kaha Tsifran OD e ka baka ho fokotseha ha lebelo la maikutlo le tlhokomelo ea psychomotor.

Bokhachane le pelehi

Ha ho kgothaletswe ho sebelisa Tsifran OD nakong ea kemaro.

Kaha ciprofloxacin e hloekisoa lebeseng la matsoele, haeba ho hlokahala ho fana ka moriana ona nakong ea lebone, ho anyesa ho lokela ho emisoe.

Sebelisa bongoaneng

Ho khethoa ha Cyfran OD bakeng sa kalafo ea bakuli ba ka tlase ho lilemo tse 18 ho kopantsoe, kaha ts'ebetso ea ho theha masapo ha e so felle.

Ka mosebetsi o sa sebetseng oa renal

Ts'ebeliso ea Cifran OD e tšoaetsanoe ho bakuli ba nang le bothata bo sa foleng ba 'mele bo nang le CC tlase ho 29 ml / min, ho kenyeletsoa ho hemodialysis le peritoneal dialysis.

Tlhokomeliso e lokela ho sebelisoa ho hloleha ha renal le CC 35-50 ml / min.

Ka ho se sebetse hantle ha sebete

Ka tlhokomeliso, ho hlokahala ho fana ka Tsifran OD ka ho hloleha ho matla ha sebete.

Sebelisa botsofaling

Ho lokela ho fanoe ka tlhokomeliso mabapi le ho khethoa ha fluoroquinolones ho bakuli ba tsofetseng, ho nahanela menyetla ea ho fokotseha ho amanang le lilemo ho ts'ebetso ea bona ea liphio, le khalemelo ea lethathamo la litekanyetso tse tsamaellanang le tekanyo ea tlolo ea molao.

Ka tšebeliso e tšoanang ea Tsifran OD:

metronidazole, beta-lactams, clindamycin, aminoglycosides le tse ling tse antimicrobials: baka synergism. Bakeng sa kalafo e atlehileng ea ts'oaetso e bakiloeng ke li-specseles tsa Pseudomonas, motsoako le ceftazidime le azlocillin, ts'oaetso ea lefutso la lefu la tsoekere le lithibela-mafu tsa beta-lactam (meslocillin, azlocillin), ts'oaetso ea staphylococcal le vancomycin, isoxazolpenicillin ts'oaetso, anaerobic aminerocytamines, anaerobic aminerocytamines
theophylline: e eketsa bongata ba mali a mali,
tizanidine: e eketsa kotsi ea ho fokotseha hoa khatello ea mali, ponahalo ea ho otsela,
litlhare tsa immunosuppression le antitumor: fokotsa ho amoheloa ha Cyfran OD ha ho nooa ka molomo,
didanosine: e thusa ho fokotsa ho monya ha ciprofloxacin,
li-antacid tse kenyelletsang aluminium kapa magnesium hydroxide ka sebopeho: kenya letsoho ho fokotseheng ha monko oa ciprofloxacin, ka hona motsoako ona oa hanyetsoa,
Lithethefatsi tse thibelang secretion ea tubular, ho kenyelletsa le phenenecid: fokotsa phokotseho ea renal ea ciprofloxacin,
analgesics: baka litlamorao tse matla tsa ciprofloxacin e tsoang tsamaisong ea methapo e bohareng,
phenytoin: e ka fokotseha kapa ea eketsa khatello ea hau ea plasma,
sucralfate: e fokotsa ho amoheloa ha Cyfran OD,
histamine H2 receptor antagonists: u se ke ua ba le phello e kholo litabeng tsa bioavailability ea ciprofloxacin,
anticoagulants ea molomo, ho kenyelletsa warfarin le lintho tse tsoang ho eona: ntlafatsa ts'ebetso ea bona, ka hona, ha e kopantsoe le moriana, lithuto tse tloaelehileng tsa mokhoa oa ho kopanya mali li hlokahala,
glyburide: e ka baka hypoglycemia e matla,
li-activine tsa hypoglycemic tsa molomo, caffeine le li-xanthine tse ling: eketsa boemo ba bona ba mahloriso le ho eketsa T1 / 2,
metoclopramide: e potlakisa ho monya,
li-uricosuric agents: hoo e ka bang 50% e liehisa ho felisoa ha ciprofloxacin, e bakang keketseho ea plasma ea eona,
cyclosporine: e matlafatsa sephetho sa eona sa nephrotoxic. Kaha ho na le keketseho ea serum creatinine, boemo ba eona bo tlameha ho laoloa makhetlo a 2 ka beke.

Lipehelo le maemo a polokelo

Qoba hole le bana.

Boloka ka mocheso ho fihlela ho 25 ° C sebakeng se omileng.

Bophelo ba Shelf ke lilemo tse 2.

Lipehelo tsa Maemo a Phomolo ea meriana

E fanoe ke lengolo la ngaka.

Litlhahlobo mabapi le Tsifran OD

Tlhahlobo ea Tsifran OD e ntle, e bontša ts'ebetso e phahameng ea bongaka kalafong ea mafu a mangata a baktheria.

Bakuli ba tlaleha mamello e ntle ea Cifran OD, ho se be teng ha litlamorao tse boletsoeng, ho qala ka potlako ho bohloko bo boholo.

Theko ea Tsifran OD libakeng tsa meriana

Theko ea Tsifran OD 1000 mg ka pakete e nang le matlapa a 10 e kanna ea ba li-ruble tse 267-325. Matlapa a 10 a Tsifran OD 500 mg a ja li-ruble tse 170-206.

Litšobotsi tse akaretsang. Moetso:

Matlapa, a koahetsoeng, ketso ea nako e telele, tafoleng e le 'ngoe.
ciprofloxacin 500 mg, 1000 mg
ka har'a lithunthung tse 5 likhomphutha., ka paketeng ea likarete tsa 1 kapa tse 2.

Tlhaloso Letlapa "Tsifran® OD 500 mg": oval, ho tloha ho tšoeu ho isa ho tšoeu, e koahetsoeng ka filimi, e hatisitsoeng ka enke ea lijo tse ntšo - "Cifran OD 500 mg".
Matlapa a Cifran® OD 1000 mg: oval, ho tloha tšoeu ho isa ho e tšoeu, e koahetsoeng ka filimi, e hatisitsoeng ka enke ea lijo tse ntšo - Cifran OD 1000 mg.

Lintlha tsa kopo:

Ho bakuli ba bang ba fumanang fluoroquinolones, maikutlo a kutloisiso a ile a bonoa. Ho pepesetsoa ho pepesehela khanya ea letsatsi le mahlaseli a letsatsi ka kotloloho ho lokela ho qojoa. Haeba ts'ebetso ea photosensitivity e etsahala, ho khothalletsoa ho khaotsa ho sebelisa lithethefatsi. Kaha Cifran® OD ke lithethefatsi tse nang le litlamorao tse ka fetolehang liphekeng, ha e khothalletsoe hore e sebelisoe ho bakuli ba nang le ts'ebetso ea renal e sebetsanang le lefu la Cl.

Tsifran OD - setlhare sa ketso ea nako e telele, matlapa a khetla. Lebitso le amohetsoeng ho tsa bongaka tsa machaba ke ciprofloxacin.

Tlhaloso le meriana

Moriana o hlahisoa ka tsela ea matlapa a tšoeu a oval. E 'ngoe le e' ngoe e koahetsoe ka filimi. Ka lehlakoreng le leng ho na le ho tšoaea - Cifran ODSOOMG. Ho sebelisoa enke ea lijo ho ngola. Ha o bala, letlapa le ka ba le bobebe haholoanyane.

Sena se bohlokoa! Ketso ea moriana e reretsoe ho timetsoa ha mefuta e mengata ea "pathogenic microflora" (baktheria). Setlhare se fuoe methapo ea methapo ea tlhaho.

Foromo ea litlhare - matlapa, a pakiloeng ka lithutsoana tsa likotoana tse 5. Ka lebokoseng la 1 kapa 2 maleiri.

Motsoako o sebetsang oa lithethefatsi ke ciprofloxacin.

"Tsifran OD" (500 mg) - e na le 500 mg ea motsoako o sebetsang,
"Tsifran OD" (1000 mg) - 1000 mg ea motsoako o sebetsang.

Alginate le sodium bicarbonate,
Magnesium stearate,
Talc,
Silica

Khemikhale e hlophisitsoeng ka khetla:

Matlapa a sebelisoa e le pheko bakeng sa li-pathologies tse susumetsoang ke likokoana-hloko tsa pathological:

Sinusitis
Pathologies ea mokhoa oa ho hema oa tlhaho e sa foleng, e tsamaeang le ho ruruha,
Mefuta e fapaneng ea cystitis, pyelonephritis,
Ramatiki e sa foleng ea baktheria,
Mokotla
Li-pathologies tsa kahare tsa mpa tse nang le mathata, (kalafo e laetsoe hammoho le metronidazole),
Mekhoa ea lefutso ho letlalo la tlhaho e sa foleng,
Ts'ebetso ea ts'oaetso ea ts'oaetso manonyeletsong le liseleng tsa masapo,
Mathata a Stool a bakoang ke ts'oaetso,
Mofuthu oa typhoid,
Cholecystitis.

Ho nwa moriana ona ka lihlopha tse ikhethang tsa bakuli

Ka ho senyeha ho hoholo ha tšebetso ea fig.

Ka ho se sebetse hantle 'meleng, bophelo ba halofo ea ntho e sebetsang bo eketseha hanyane. Ka ha 'nete ena, ngaka e lokela ho fetola tekanyetso le bolelele ba nako ea phekolo.

Ka ho se sebetse hantle ha sebete.

Ho ile ha etsoa liphuputso ho bakuli ba nang le lefu la cirrhosis, liphetoho tse bohlokoa phello ea lithethefatsi ha lia ka tsa bonoa. Ha u fana ka litlhare, ho lokela ho hopoloa hore ha ho na lithuto tse entsoeng bakeng sa bakuli ba nang le bothata ba sebete.

Tsifran OD le ho ima.

Ho fanoa ka bokhoni bo phahameng ba ho kenella ba moriana, ho nka Cifran OD nakong ea kemolo le ho lactation ha ho kgothaletswe.

Sena se bohlokoa! Nakong ea kemaro, ho beoa ha moriana ho ka etsahala haeba kotsi ea ho bophelo ba mme e phahame ho feta kotsi ho lesea, empa letsoele le lokela ho emisoa.

Litlamorao

Litho tsa ka tlung:

Nausea (maemong a sa tloaelehang, ho hlatsa)
Litšitiso tsa litulo
Ho hloka botsitso le ho thunya ka mpeng,
Boikutlo ba ho thunya ka mpeng
Anorexia
Hepatitis
Haeba mokuli a tšoeroe ke lefu la sebete, ho ka hlaha matšoao a lefu la sethoathoa.

Mokhoa o hlasimolohileng:

Ho tšaba leseli
Mathata a ho robala
Ho teneha
Tsietsing
Mokhathala
Boikutlo ba ho tšoenyeha
Pherekano ea monahano
Boemo ba khatello ea maikutlo.

Litho tsa maikutlo:

Latsoa ho khopama,
Ho khelosa pono ea mmala,
Monko o sa foleng
Ho utloahala molumo o mongata litsebeng.

Ts'ebetso ea pelo:

Tachycardia
Khatello ea khatello,
Ho fufuleloa ha sefahleho
Sekhahla sa pelo sea tlama.

Sisteme ea Hematopoietic:

Leukocytosis
Boloetse
Leukopenia
Eosinophilia.

Sistimi ea Urinary:

Nephritis mokhatlong o boima (maemong a sa tloaelehang, ho hloleha ho phekoloa ke lefu la tsoalo),
Hematuria
Dysuria
Boloka urinary 'meleng,
Albuminuria

Tloso:

Ho hlohlona le likokoana-hloko
Malepa a hlaha a tsamaeang le ho tsoa mali,
Ho hlahlangoa makhopho le maqhutsu a manyane,
Letlalong, hlahella lisele tsa hemorrhages,
Maemong a sa tloaelehang, ho ruruha sefahleho le larynx hoa khoneha,
Ho hema hanyane
Vasculitis
Mefuta e fapaneng ea erythema,
Necrolysis.

Sistimi ea musculoskeletal:

Ramatiki
Myalgia
Arthralgia,
Tenovaginitis.

Sena se bohlokoa! Maemong a mang, bakuli ba utloa mofufutso o feteletseng, bofokoli bo akaretsang, candidiasis bo ka hlaha.

Ho sebelisana le meriana e meng

Ha phekolo ea Cifran OD le glucocorticosteroids, bakuli ba fetang lilemo tse 60 ba eketsa menyetla ea tšenyo ea tendon.
Ha lithethefatsi tse khothalletsang alkalization ea moroto li kenngoa hammoho le Cifran OD, monyetla oa litlamorao tsa nephrotic oa eketseha.
Ho na le kotsi e kholo ea ho bonts'a litla-morao tsa neurotoxic ha u ntse u phekoloa le Cifran OD le lithethefatsi tse ling tse seng khahlanong le 'mele tse amanang le mali.
Ho bohlokoa ho boloka nako ea phomolo ea lihora tse peli pakeng tsa li-antacids, meriana e thehiloeng ho tšepe le cyfran OD. Phallo e fokolang ke lihora tse peli, ho seng joalo katleho ea meriana e fokotseha haholo.
Lihlahisoa li ama hampe monyaolo oa motsoako o sebetsang.

Seo u lokelang ho se batla

Bakuli ba fumaneng phekolo ea fluoroquinol ba bontšitse ho eketseha hoa khanya. Bakeng sa nako ea kalafo, o hloka ho fokotsa ho pepesetsoa khanya ea letsatsi le mahlaseli a kotsi a matla a letsatsi. Haeba monyetla oa ho chona o eketseha haholo, ngaka e etsa qeto ea ho fokotsa tekanyetso kapa ho hlakola sethethefatsi seo, 'me e tlosoe ka moriana o mong.

Tsifran OD e na le chefo e feto-fetohang liphellong. Ha ho kgothaletswe ho fana ka matlapa a:

Mosebetsi o sa sebetseng oa renal,
Hemodialysis
Ho foufatsa.

Tsifran OD e ka qholotsa nts'etsopele ea pseudomembranous colitis. Lits'ebetso tsa lefutso li ka hlaha ka mokhoa o bonolo kapa ka mokhoa o sokelang bophelo ba mokuli. Haeba kalafo e tsamaisana le lets'ollo le matla le le tšoarellang nako e telele, haeba mafu a setulong a hlaha hang kamora 'ona, ho na le lithuto tse lokelang ho etsoa ho kenyelletsa menyetla ea pseudomembranous colitis. Haeba ts'oaetso e netefalitsoe, ho hlokahala hore hang-hang u hlakole Tsifran OD le ho etsa kalafo ea matšoao.

Ho kenyelletsa menyetla ea kristale, o ke ke oa feta tekano e lumelletsoeng mme oa nwa metsi a mangata nakong eohle ea kalafo.

Moriana o fuoa feela mabaka a bophelo, haeba mokuli a na le:

Lefu la ho akheha
Maqhubu
Psychology
Tšenyo ea boko.

Li-pathologies tse joalo li ka baka tšusumetso e mpe e tsoang ho tsamaiso ea methapo e bohareng.

Ts'ebetsong ea bongaka, ho na le linyeoe tsa tendon deformation ha phekolo ea fluoroquinol e ne e laetsoe. Ho matšoao a pele a kotsi - ho se khotsofale ho teng ka har'a tendon le matšoao a tenosynovitis - o lokela ho etela setsebi ho lokisa litekanyetso kapa ho hlakola meriana.

Sena se bohlokoa! Bakeng sa nako ea kalafo, motho o lokela ho lekanya ho pepesetsoa letsatsi le ho khetholla mofuta oa ketso eo ho hlokahalang hore motho a tsepamise maikutlo ho eona, le ho fokotsa taolo ea lipalangoang.

Bophelo ba ho boloka le ho qeta

Setlhare se bolokiloe ka mocheso ho isa ho li-degrees tsa 25, sebakeng se lefifi le se omileng. Tsifran OD e lula e sebetsa selemo se le seng.

Basigen - ho tloha li-ruble tse 15,
Ciprofloxacin - ho tloha li-ruble tse 17,
Ciprofloxacin AKOS - ho tloha li-ruble tse 20,
Ciprofloxacin Bufus - ho tloha li-ruble tse 25,
Ciprofloxacin SOLOpharm - ho tloha li-ruble tse 30.

Seo lingaka li se bolelang ka lithethefatsi.

Nikolai Petrovich, setsebi sa kalafo: Ke fana ka lipilisi tsa ts'ebetso ea methapo ea methapo ea methapo. Matla a kliniki a bonahatsoa ka letsatsi la pele. Ke fana ka lengolo la Cifran OD e le pheko, hammoho le thibelo pele ke buuoa. Ha e le mefokolo - Letlapa le leholo ka ho lekaneng, ho thata ho le metha.

Olga Petrovna, ngaka ea mafu a basali: Ha a bapisoa le lithethefatsi tse ling tsa antibacterial, Tsifran OD e na le tšusumetso e matla, palo e fokolang ea litlamorao e bonahatsoa. Ke batla ho hlokomela ho sebetsa hantle ha matlapa. Haeba ho na le bopaki bo nepahetseng, ke Tsifran OD ea khethiloeng pele.

Seo bakuli ba se buang ka lithethefatsi.

Vera ea lilemo li 39: Tsifran OD e kopantsoeng le Smartprost e thusitse monna oa ka ho tsoa ho lefu la matsoele.

Oksana, ea lilemo li 28: Ke leboha haholo ngaka e pholositseng mora oa ka sepetlele ka pneumonia e 'ngoe ea lefatše. O ile a khetha Tsifran OD, mme kamora matsatsi a 3 mora oa hae a qala ho fola, mme libeke tse peli hamorao ho phatloha ha mapheo ho bontšitse hore tšoso e felile.

Nikita, ea lilemo li 57: Ke noele moriana ona nakong ea bohloko ba ka, 'me thempereichara e ile ea khutlela ho mantsiboea. Leha ho le joalo, Tsifran OD e ile ea nkutloisa litla-morao - molomo o omileng, hlooho e bohloko, maikutlo a mokhathala.