Mokhoa oa ho sebelisa lithethefatsi Rosinsulin M?
Ho emisoa bakeng sa s / c tsamaiso ea mmala o mosoeu, ha o eme, ho emisa ho emisa. Mokelikeli o kaholimo ho sehla o pepesang, o se nang 'mala kapa o batla o se na' mala. Ha e le hantle pula e khutla habonolo ha e sisinngoa ka bonolo.
| 1 ml | |
| insulin biphasic boenjiniere ba motho ba tlhaho | 100 IU |
Bahlomphehi: protamine sulfate 0,12-0.20 mg, sodium hydrogen phosphate dihydrate 0,26 mg, crystalline phenol 0.65 mg, metacresol 1.5 mg, glycerol (glycerin) 16 mg, metsi d / le ho fihlela 1 ml.
Li-ml tse 5 - libotlolo (5) - li-blister pack (aluminium / PVC) (1) - liphutheloana tsa karete.
10 ml - libotlolo (1) - lipakete tsa karete.
3 ml - li-cartridges (5) - sephutheloana sa makhopho (aluminium / PVC) (1) - lipakete tsa karete.
Ketso ea pharmacological
Motsoako oa Rosinsulin M 30/70 ke litokisetso tsa insulin tsa mahareng. Sebopeho sa moriana se kenyelletsa "insulin" insulin (30%) le insulin-isophan (70%). Insulin e kenella le receptor e itseng ho membrane e ka ntle ea cytoplasmic ea lisele mme e theha mohopolo oa "insulin-receptor". Ka ts'ebetso ea li-biosynthesis tsa cAMP (liseleng tsa mafura le lisele tsa sebete) kapa, ka ho kenella ka seqo ka seleng (mesifa), motsoako oa "insulin-receptor" o hlohlelletsa mekhoa e meng e kenelletseng synthetise ea li-enzymes tse 'maloa tsa bohlokoa (hexokinase, pyruvate kinase, glycogen synthase, jj.). Ho fokotseha ha tsoekere maling ho bakoa ke keketseho ea lipalangoang tsa eona tse makatsang, ho monya ho eketsehileng le ho ts'oaroa ha lisele, ho hlohlelletsoa ha lipojiais, glycogenogeneis, synthetiki ea protheine, phokotseho ea tekanyo ea tlhahiso ea tsoekere ke sebete, jj.
Nako ea ts'ebetso ea litokisetso tsa insulin e haholo-holo ka lebaka la ho monya, ho latela lintlha tse 'maloa (mohlala, ka tekanyetso, mokhoa le sebaka sa tsamaiso). Ka hona, boemo ba ts'ebetso ea "insulin" bo ka fetoha ka ho fokotseha hoa bohlokoa ho batho ba fapaneng le ho motho a le mong.
Ka karolelano, kamora ho tsamaisoa ha sc, Rosinsulin M e kopanya 30/70 e qala ho sebetsa ka lihora tse 0.5, phello e phahameng e hlaha nako ea nako ho tloha lihora tse 4 ho isa ho tse 12, nako ea ts'ebetso e fihlile ho lihora tse 24.
Matšoao a moriana oa Rosinsulin M kopanya 30/70
- mofuta oa 1 lefu la tsoekere ho batho ba baholo,
- mofuta oa lefu la tsoekere la 2 lefu la tsoekere: sethala sa ho hanyetsa li-antic hypoglycemic, ho hanyetsa lithethefatsi tsena (nakong ea phekolo e kopaneng), maloetse a kopanang.
| Khoutu ea ICD-10 | Pontšo |
| E10 | Type 1 lefu la tsoekere |
| E11 | Type 2 lefu la tsoekere |
Melemo ea litekanyetso
Motsoako oa Rosinsulin M 30/70 o etselitsoe tsamaiso ea sc. Tekanyetso ea lithethefatsi e khethoa ke ngaka ka bonngoe boemong bo bong le bo bong, ho ipapisitse le khatello ea mali maling. Ka karolelano, tekanyetso ea letsatsi le letsatsi ea lithethefatsi e tloha ho 0.5 ho isa ho 1 IU / kg boima ba mmele, ho latela litšobotsi tsa motho ka mong le khatello ea tsoekere maling.
Mocheso oa "insulin" o sebelisoang o lokela ho ba ka mocheso oa kamore. Pele o sebelisoa, ho emisoa ho tsoakoa ka bonolo ho fihlela junifomo. Motsoako oa Rosinsulin M 30/70 o atisa ho kenngoa ka lethekeng. Ho entoa ho ka etsoa le kahara mpa ea mpa ea mpa, kapa mahetleng ka mokokotlong oa mesifa e boreleli.
Hoa hlokahala ho fetola sebaka sa ente kahare ho sebaka sa anatomical ho thibela nts'etsopele ea lipodystrophy.
Litla-morao
Ka lebaka la phello ea metabolism ea carbohydrate: maemo a hypoglycemic (pallor ea letlalo, mofufutso o eketsehang, palpitations, ho thothomela, tlala, ho ruruha, paresthesia molomong, hlooho e bohloko). Hypoglycemia e matla e ka lebisa ho hola ha mesifa ea hypoglycemic.
Boitšoaro bo kulang: ka seoelo - lekhopho la letlalo, edema ea Quincke, e sa tloaelehang haholo - ho ts'oaroa ha anaphylactic.
Boitšoaro ba lehae: hyperemia, ho ruruha le ho hlohlona sebakeng sa ente, ka tšebeliso ea nako e telele - lipodystrophy sebakeng sa ente.
Tse ling: edema, liphoso tsa nakoana tsa ho hlaka (hangata qalong ea phekolo).
Bokhachane le pelehi
Ha ho na lithibelo ho kalafo ea lefu la tsoekere le "insulin" nakong ea kemolo, hobane "insulin" ha e tšeloe mokoallo oa mali. Ha u rera ho ima le nakong ea eona, hoa hlokahala ho matlafatsa kalafo ea lefu la tsoekere. Tlhokahalo ea insulin hangata e fokotseha ho "trimester" ea pele ea bokhachane mme butle-butle e eketseha ho li-trimesters tsa bobeli le tsa boraro.
Nakong ea ha lesea le hang kamora ho hlaha, litlhoko tsa insulin li ka theoha haholo. Nakoana kamora ho hlaha, tlhoko ea insulin kapele e khutlela boemong bo neng bo le pele ho ima. Ha ho na lithibelo ho kalafo ea lefu la tsoekere le "insulin" nakong ea ho anyesa. Leha ho le joalo, ho ka hlokahala hore u fokotse tekanyetso ea insulin, ka hona, ho hlahloba ka hloko bakeng sa likhoeli tse 'maloa hoa hlokahala pele ho tiisa tlhokahalo ea insulin.
Litaelo tse khethehileng
Pele o sebelisoa, hlahloba ka hloko ponahalo ea se kahare sa botlolo mme o se ke oa sebelisa motsoako oa Rosinsulin M 30/70 haeba, kamora ho kopanya, ho emisoa ho na le li-flakes kapa haeba likarolo tse tšoeu li khomarela tlase kapa marako a botlolo, ho theha phello ea sebopeho sa serame.
Se ke oa sebelisa motsoako oa Rosinsulin M 30/70 haeba, kamora ho sisinyeha, ho emisoa ho sa fetohe le le tšoeu ebile ho le maru ka mokhoa o tšoanang.
Khahlano le semelo sa kalafo ea "insulin", ho hlokahala hore ho lule ho shebiloe tsoekere ea mali.
Lisosa tsa hypoglycemia ho ekelletsa ho insulin e ngata e ka ba: ho nkeloa lithethefatsi, ho tlola lijo ka bongata, ho hlatsa, lets'ollo, khatello ea mmele, mafu a fokotsang tlhoko ea insulin (ts'ebetso ea sebete le ts'ebetso ea liphio, hypofunction ea adrenal cortex, pituitary kapa gland ea tšoelesa). le ho sebelisana le lithethefatsi tse ling.
Ho hloka dosing kapa ho sitisoa ka tsela e fosahetseng tsamaisong ea insulin, haholo-holo ho bakuli ba nang le lefu la tsoekere la mofuta oa 1, ho ka lebisa ho hyperglycemia. Hangata, matšoao a pele a hyperglycemia a fetoha butle-butle ka lihora tse ngata kapa matsatsi. Tsena li kenyelletsa lenyora, ho ruruha ho eketsehileng, ho nyekeloa, ho hlatsa, ho tsekela, ho redness le ho omella ha letlalo, molomo o omileng, ho felloa ke takatso ea lijo, monko oa acetone moeeng o tsoang. Haeba e sa phekoloe, hyperglycemia ea mofuta oa 1 lefu la tsoekere e ka lebisa nts'etsopeleng ea lefu la tsoekere le kotsi ea lefu la tsoekere. Tekanyetso ea "insulin" e lokela ho lokisoa bakeng sa ts'ebetso ea qoqotho e senyehileng, lefu la Addison, hypopituitarism, lefu le sa sebetseng hantle la sebete le liphio le lefu la tsoekere ho batho ba lilemo tse fetang 65.
Khalemelo ea tekanyetso ea insulin le eona e ka hlokahala haeba mokuli a eketsa boemo ba ho ikoetlisa kapa a fetola lijo tse tloaelehileng.
Maloetse a kopaneng, haholo-holo tšoaetso le maemo a tsamaeang le feberu, a eketsa tlhoko ea insulin.
Phetoho ea moriana le phetoho ea mofuta o mong oa "insulin" ho ea ho e ngoe e lokela ho etsoa ka taolo ea ngaka le ho beha leihlo tlhahiso ea tsoekere maling. Setlhare se theola mamello ea joala.
Ka lebaka la monyetla oa pula lipakeng tsa li-catheter, ho khothalletsoa ts'ebeliso ea lithethefatsi lipompong tsa insulin.
Tšusumetso ho bokhoni ba ho khanna makoloi le litsamaiso tsa taolo
Mabapi le sepheo sa mantlha sa insulin, phetoho ea mofuta oa eona kapa boteng ba khatello e kholo ea 'mele kapa ea kelello, hoa khoneha ho fokotsa bokhoni ba ho khanna koloi kapa ho laola mekhoa e fapaneng, hammoho le ho etsa lintho tse ling tse kotsi tse hlokang tlhokomelo e potlakileng le lebelo la karabelo ea kelello le koloi.
Bongata
Matšoao: ho na le overdose, hypoglycemia e ka hlaha.
Phekolo: mokuli a ka felisa hypoglycemia e bonolo ka ho ja lijo tse nang le tsoekere kapa tse nang le lik'habohaedreite tse ngata. Ka hona, ho khothalletsoa hore bakuli ba nang le lefu la tsoekere ba nke tsoekere, liswiti, likuku kapa lero le monate la litholoana le bona. Maemong a tebileng, ha mokuli a lahleheloa ke kelello, ho fanoa ka tharollo ea 40% iv
dextrose (glucose), ka / m, s / c, ka / ka - glucagon. Kamora ho hlaphoheloa kelellong, mokuli o khothalletsoa ho ja lijo tse nang le lik'habohaedreite ho thibela nts'etsopele ea hypoglycemia.
Ho sebelisana le lithethefatsi
Hona le meriana e mengata e amang tlhoko ea insulin. Hypoglycemic phello ea ka insulin ntlafatsa lithethefatsi molomo hypoglycemic, Mao inhibitors, inhibitors Ace, k'habone inhibitors anhydrase, khetha beta-blockers, bromocriptine, octreotide, sulfonamides, anabolic steroid, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, litokisetso lithium litokisetso tse nang le ethanol.
Hypoglycemic phello ea ka insulin litsebeng lithibela-pelehi molomo, corticosteroids, thyroid li-hormone, thiazide diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazol, clonidine, k'halsiamo le kanaleng blockers lieha, diazoxide, morphine e, phenytoin, bokoali, sulfinpyrazone, epinephrine, histamine H 1 receptor.
Tlas'a tšusumetso ea reserpine le salicylates, ho fokolisa le ho eketsa ts'ebetso ea moriana ho ka khoneha.
Mokhoa oa ho sebelisa: litekanyetso le kalafo
Setlhare sena se etselitsoe tsamaiso e tlisoang ke subcutaneous. Tekanyetso ea lithethefatsi e khethoa ke ngaka ka bonngoe boemong bo bong le bo bong, ho ipapisitse le khatello ea mali maling. Ka karolelano, litekanyetso tsa letsatsi le letsatsi tsa moriana li tloha ho 0,3 ho isa ho 1 IU / kg boima ba mmele, ho latela litšobotsi tsa motho ka mong le khatello ea tsoekere maling.
Tlhokahalo ea insulin ea letsatsi le letsatsi e ka ba e phahameng ho bakuli ba hanyetsang insulin (mohlala, nakong ea ho kena bohlankaneng kapa ho bakuli ba nang le botenya), le tlase ho bakuli ba nang le tlhahiso ea insulin ea insulin.
Mocheso oa "insulin" o sebelisoang o lokela ho ba ka mocheso oa kamore. Pele o sebelisoa, ho emisoa ho tsoakoa ka bonolo ho fihlela junifomo. Hangata moriana o tsamaisoa ka mokhoa o potelletseng ka thipa. Ho entoa ho ka etsoa le sebakeng sa lebota le ka ntle la mpa, li-buttocks kapa sebakeng sa mesifa ea lehetla le sephara. Ka kenyelletso ea moriana ka serope, ho kenngoa butle butle ho feta ha ho kenngoa libakeng tse ling.
Hoa hlokahala hore kamehla o fetole sebaka sa ente kahare ho sebaka sa anatomical ho thibela nts'etsopele ea lipodystrophy.
Ha o sebelisa lipentšele tsa syringe tse tlatsitsoeng tse sa tlatseng tse ngata tse hlokahalang bakeng sa ente e phetseng, hoa hlokahala ho tlosa pene ea syringe sehatsetsing pele o e sebelisa pele le ho tlohela lithethefatsi hore li fihle mocheso oa kamore. Hoa hlokahala ho kopanya ho emisoa ha ROSINSULIN M Remix 30/70 ka pentšele ea syringe e ka lahleloang hang-hang pele e sebelisoa. Ho emisoa ho kopaneng hantle ho lokela ho ba tšoeu ka tsela e tšoanang 'me ho koahetsoe maru. Setlhare se ka peni ea linare tse lahloang se ke ke sa sebelisoa haeba se leqhoa. Ho bohlokoa hore o latele litaelo tsa tšebeliso ea pente ea syringe e fanoeng le moriana.
Mafu a khahlang, haholo a tšoaetsanoang le feberu, hangata a eketsa tlhoko ea mmele ea insulin. Phetoho ea mori le eona e ka hlokahala haeba mokuli a e-na le mafu a a amanang le a liphio, sebete, ho senyeha hoa sesole sa adrenal, gland.
Tlhokahalo ea tokiso ea tekanyetso e ka hlaha le ha o fetola ts'ebetso ea 'mele kapa lijo tse tloaelehileng tsa mokuli. Ho ka hlokahala phetoho ea tekanyetso ha u fetisetsa mokuli ho tsoa mofuteng o mong oa insulin ho ea ho e 'ngoe.
Litlamorao
Ketsahalo e mpe e atileng haholo ka insulin ke hypoglycemia. Nakong ea liteko tsa tliliniki, le nakong ea ts'ebeliso ea lithethefatsi ka mor'a ho lokolloa 'marakeng oa bareki, ho ile ha fumaneha hore maemo a hypoglycemia a fapana ho latela palo ea bakuli, litekanyetso tsa litekanyetso tsa lithethefatsi, le taolo ea glycemic.
Boemong ba pele ba kalafo ea insulin, liphoso tse hlahang hape, edema ea phello le karabelo setsing sa ente (ho kenyelletsa bohloko, redness, urticaria, ho ruruha, hematoma, ho ruruha le ho hlohlona sebakeng sa ente). Hangata matšoao ana ke a nakoana. Phetoho e potlakileng taolong ea glycemic e ka lebisa ho "acute pain neuropathy" e atisang ho fetoha. Ho matlafatsoa ha kalafo ea insulin ka ntlafatso e matla taolong ea metabolism ea carbohydrate ho ka lebisa ho mpefala ha nakoana maemong a lefu la tsoekere, ha ntlafatso ea nako e telele taolong ea glycemic e fokotsa kotsi ea tsoelo-pele ea lefu la tsoekere.
Lokolla liforomo le sebopeho
Ho emisoa bakeng sa tsamaiso e poteletseng ea 100 IU / ml e fumaneha ka mokhoa oa:
- botlolo ea 5 le 10 ml,
- 3 ml ea cartridge.
1 ml ea lithethefatsi e na le:
- Motsoako o ka sehloohong ke "insulin" ea 100 ea motho.
- Lisebelisoa tse thusang: protamine sulfate (0.12 mg), glycerin (16 mg), metsi a ente (1 ml), metacresol (1.5 mg), crystalline phenol (0.65 mg), sodium hydrogen phosphate dihydrate (0.25 mg).
Ho emisoa bakeng sa tsamaiso ea subcutaneous ea 100 IU / ml e fumaneha ka mokhoa oa: botlolo ea 5 le 10 ml, mokotla oa 3 ml.
Mofumahali
Ho monya ka botlalo le ponahatso ea phello ho latela tekanyetso, mokhoa le sebaka sa ente, insulin mahloriso. Setlhare se senngoa ke ketso ea insulinase lipelong. E qala ho sebetsa halofo ea hora kamora tsamaiso, e fihla sehlohlolong ka lihora tse 3-10 'meleng, e emise ho ts'oara kamora letsatsi la 1.
Sebopeho, sebopeho le mochine oa mosebetsi
"Rosinsulin" e bua ka lithethefatsi tsa "sehlopha sa" hypoglycemic agents ". Ho latela lebelo le nako ea ts'ebetso, ho na le:
Tsoekere e fokotseha hang-hang! Lefu la tsoekere ha nako e ntse e tsamaea le lona le ka lebisa ho letšoele la maloetse, a kang mathata a pono, maemo a letlalo le moriri, liso, maloetse a mokokotlo esita le hlahala ea mofets'e! Batho ba ile ba ruta boiphihlelo bo bohloko ho fetolela maemo a bona a tsoekere. bala ho tsoela pele.
- "Rosinsulin S" e nang le nako e telele ea ketso,
- "Rosinsulin R" - hakhutšoanyane,
- "Rosinsulin M" ke moemeli ea kopantsoeng ea "insulin" "insulin" "insulin" le "70" "insulin" "isophan".
Motsoako ke insulin e tsoang 'meleng oa motho ka liphetoho tsa DNA. Litaelo li bonts'a hore moeli oa ts'ebetso o ipapisitse le tšebelisano ea motsoako o ka sehloohong oa lithethefatsi ka lisele le sebopeho se latelang sa mochine oa insulin. Ka lebaka leo, motsoako oa li-enzyme tse hlokahalang bakeng sa ts'ebetso e nepahetseng ea 'mele oa etsahala. Normalization ea maemo a tsoekere e etsahala ka lebaka la metabolism ea intracellular le ho monya ho lekaneng. Ho latela litsebi, sephetho sa ts'ebeliso se bonoa lihora tse 1-2 kamora tsamaiso tlas'a letlalo.
"Rosinsulin" ke setlamo bakeng sa tsamaiso tlasa letlalo. Ketso e bakiloe ke litaba tsa insulin-isophan.
Ntle le moo, lithethefatsi li tšoeu ka 'mala o bosoeu bo bokhubelu. Ha ho se na thothomelo, e aroloa hore e be mokelikeli o hlakileng 'me e be pula. Ho latela litaelo, "Rosinsulin" e lokela ho sisinngoa pele ho tsamaiso. Ntle le moo, sebopeho sa lithethefatsi se kenyeletsa lintho tse hlalositsoeng tafoleng:
