Lorista N o lokollotsoe ka mokhoa oa matlapa a koahetsoeng ka filimi: oval, biconvex hanyane, ho e 'ngoe ea mahlakore a kotsi, mmala ho tloha botala bo botala ho isa ho mosehla, motheo o mosoeu o khetholloa ka kink (li-pcs tse 7. Ka marang-rang, ka pakete ea karete ea 2 4, 8, 12 kapa 14 maleiri, li-pcs tse 10. Litlatsetsong, ka pakete ea likarete tsa 3, 6 kapa 9, li-PC tse 14. Litlatsetsong, ka pakete ea karete ea 1, 2, 4, 6 kapa 7, .

Letlapa le le leng le na le:

metsoako e sebetsang: losartan (ka sebopeho sa losartan potasiamo) - 50 mg, hydrochlorothiazide - 12,5 mg,
likarolo tse thusang: "cellcose" - microcrystalline cellulose, starch ea pregelatinized, magnesium stearate, lactose monohydrate,
Filimi e koahelang: macrogol 4000, hypromellose, titanium dioxide (E171), quinoline e dae (E104), talc.

Pharadodynamics

Lorista N ke setlhare se kopaneng sa antihypertensive, ts'ebetso ea sona e bakoa ke thepa ea likarolo tsa eona tse sebetsang.

Losartan ke mohanyetsi ea khethiloeng oa li-angiotensin II receptor antagonist (AT₁subtype) ea tlhaho e seng protheine. Ntho, hammoho le "carboxy metabolite" metabolism e sebetsang ea biologic EXP-3174, ho latela liphuputso tsa vivo le vitro, e thibela litla-morao tsohle tsa 'mele tse bohlokoa tsa angiotensin II ho AT₁-receptors, ho sa tsotelehe mokhoa oa motsoako oa eona, ka lebaka leo ts'ebetso ea renase ea plasma ea mali e eketsehang le mahlaseli a plasma a aldosterone a fokotseha. Ka lebaka la keketseho ea boemo ba angiotensin II, li-antibodies li etsoa ka mokhoa o sa tobang.₂li-receptors. Ketsahalo ea enzyme e amehang ho metabolism ea bradykinin - kininase II, ha e thibelle.

Losartan e theola OPSS (ho potoloha ha methapo ea methapo), e theola khatello ea methapo ea mali le mokokotlo, mme e boetse e na le diuretic. Ka ho thibela myocardial hypertrophy, losartan e eketsa monyetla oa ts'ebetso ea 'mele ho hloleha ha pelo (CHF).

Ka lebaka la ho nka losartan 1 nako ka letsatsi, khatello ea mali ea systolic le diastolic (khatello ea mali) e fokotsoe haholo ka lipalo. Motšehare, losartan e tloaelehileng khatello ea mali, athe matla a antihypertgency a tsamaisana le morethetho oa tlhaho oa li-circadian. Qetellong ea ketso ea tekanyetso e le 'ngoe ea moriana, ho fokotseha ha khatello ea mali e ne e le

70-80% ea matla a eona a phahameng, a hlahang kamora lihora tse 5-6 kamora tsamaiso. Losartan ha e bake matšoao a ho ikhula kamora ho khaotsa kalafo mme ha e ame boemo ba pelo haholo (sekhahla sa pelo). Ho sebetsa ha ntho ha hoa itšetleha ka bong (ho joalo ho banna le basali), hammoho le lilemo tsa bakuli.

Hydrochlorothiazide ke diaztite ea thiazide eo phello ea eona ea diuretic e thehiloeng ho tlolong ea boteng ba chlorine, sodium, magnesium, potasiamo le ion ea metsi ho distal nephron. E lieha ho felisoa ha ion ea calcium le uric acid. E na le phello e matlafatsang, e hlahang ka lebaka la vasodilation ea arterioles. Hydrochlorothiazide ha e na phello ho khatello e tloaelehileng ea mali. Tšusumetso ea eona ea diuretic e etsahala kamora lihora tse 1-2 kamora ho tsamaisoa, e fihla hofihlella kamora lihora tse 4 mme e nka lihora tse 6 - 6. Tšusumetso ea antihypertensive ea hydrochlorothiazide e hlaha ka matsatsi a 3-4, empa phekolo ea nako e telele e kanna ea hlokoa ho fumana kalafo e nepahetseng, ho tloha libeke tse tharo ho isa ho tse nne. .

Mofumahali

Li-pharmacokinetics tsa losartan le hydrochlorothiazide ka tsamaiso ea tsona e kopaneng ha e fapana le ea kalafo e arohaneng.

Dnarfabilan

33% C_max (mahloriso a mangata) plasma ea mali e khethoa hora e le 'ngoe ka mor'a ho tsamaisoa ka molomo, le C_max metabolism ea eona ea carboxy metabolite EXP -3174 e fihlella ka mor'a lihora tse 3-4,

phetisetso: losartan le EXP-3174 ke 99% kapa ho feta e tlameletsoe ho liprotheine tsa plasma, boholo ba tsona ke albin. V_d (bophahamo ba modumo) ke 34 l. Tumello ka BBB (tšitiso ea mali-a mali) e tlase haholo,

metabolism: e ba le metabolism e kholo ea "presystemic metabolism", e bitsoang. litlamorao tsa karolo ea pele e kenang ka har'a sebete, ka ho thehoa ha metabolite e sebetsang EXP-3174 (14%) le metabolites e 'maloa e sa sebetseng,

excretion: tumello ea plasma ea losartan le metabolite ea eona e sebetsang ea EXP-3174 ke

600 ml / Min (10 ml / s) le 50 ml / min (0.83 ml / s), ka ho latellana, lengolo la tumello

74 ml / min (1.23 ml / s) le 26 ml / min (0.43 ml / s), ka ho latellana. T_1/2 (halofo-ea bophelo) ea losartan - lihora tse 2, metabolite EXP-3174 - lihora tse 6-9. Hoo e ka bang 58% ea lithethefatsi li qhekelloa ka bile, ho fihla ho 35% - ke liphio.

Litšobotsi tsa Pharmacokinetic tsa hydrochlorothiazide:

ho amoheloa le ho tsamaisoa: ho amoheloa ka mor'a taolo ea molomo ho tsoa ho 60 ho isa ho 80%. C_max plasma ea mali e fihlella kamora lihora tse 1-5. Ho fihlela ho 64% ea ntho ena e tlama liprotheine tsa plasma,
metabolism le excretion: ha e tšeloe methapo, e sibolloa ke liphio kapele, T_1/2 e tloha lihora tse 5 ho isa ho tse 15

Matšoao a ho sebelisoa

Ho latela litaelo, Lorist N o khothaletsoa bakeng sa kalafo ea khatello ea mali ho bakuli ba bontšitsoeng kalafo ea ho kopanya.

Setlhare se boetse se laetsoe ho fokotsa kotsi ea lefu la pelo le lefu la bakuli ba nang le khatello ea methapo ea methapo le methapo ea methapo ea methapo.

Lingaka tsa China li re'ng ka khatello ea mali

Ke qetile lilemo tse ngata ke phekola khatello ea mali. Ho latela lipalo-palo, maemong a 89%, khatello ea khatello ea mali e baka lefu la pelo kapa stroke 'me motho oa shoa. Hoo e ka bang karolo ea bobeli ho tse tharo ea bakuli ba shoa nakong ea lilemo tse 5 tsa pele tsa lefu lena.

Ntlha e latelang - hoa khoneha ebile hoa hlokahala ho theola khatello, empa sena ha se phekole lefu ka bolona. Motsoako o le mong feela o sa hananeng le melao ea phekolo ea China ebile o sebelisoa ke lingaka tse tummeng tsa kalafo bakeng sa kalafo ea khatello ea mali ke Hyperten. Setlhare se ama sesosa sa lefu lena, se etsang hore ho felisoe khatello ea mali ka botlalo. Ho feta moo, tlasa lenaneo la mmuso, moahi e mong le e mong oa Russia Federation a ka e amohela MAHALA .

Bongaka Lorista N le Lorista ND ho ba le matšoao a tšoanang bakeng sa ts'ebeliso:

ho fokotsa likotsi lefu la pelo,
phokotso ea ho shoa hoa bakuli ba nang le hypertrophy ea ventricular e kaholimo le khatello ea kelello ea methapo,
khatello ea kelello ea methapo (mofuta oa phekolo).

Lithethefatsi ka bobeli ha lia lokela ho sebelisoa maemong a latelang:

anuria,
qhekello marang-rang,
hyperkalemia,
hypokalemia e hanyetsang,
ho senyeha ha renal kapa ho sebetsa ha sebete,
galactosemia,
ho omella,
hypotension ea methapo,
boimana
glucose kapa galactose malabsorption syndrome,
lebone
kutloisiso ea karolo efe kapa efe, ho sulfonamide derivatives,
ka tlase ho lilemo tse 18.

Sebelisa ka hlokolosi ha u:

lefu la tsoekere,
bilteryal renal artery stenosis,
tlolo ea tekanyo ea mali-electrolyte ea mali (hypomagnesemia, hypochloremic alkalosis, hyponatremia, hypokalemia),
lesapo la mokokotlo la meno,
mafu a systemic mali
hyperuricemia,
nalane ea lintho tsohle
hypercalcemia,
gout,
asthma ea bronchial,
ka nako e tšoanang le NSAIDs.

Litlamorao tse latelang li ka hlaha ka lebaka la ho sebelisa meriana ena.

ho tsekela (ha e tsamaisoe ebile e hlophisehile), ho hloka boroko, migrainehlooho e bohloko, mokhathala,
palpitations, hypotension e amanang le dithamine, tachycardiamaemong a matla - vasculitis,
khohlela, ho ruruha ha mucosa ea ka mpeng, pharyngitistšoaetso ea phefumoloho (likarolo tse holimo),
ho nyekeloa ke pelo, bohloko ba ka mpeng, lets'olloho hlatsa dyspepsia, maemong a sa tloaelehang, hepatitis, keketseho ea tšebetso ea li-enzyme tsa sebete, bilirubin, ts'ebetso ea ho fokola ha sebete,
bohloko ba morao arthralgia,myalgia,
Shenlein-Genoch pherese, phokolo ea mali,
bofokoli, bohloko ba sefuba, astheniaedema e haufi,
ho hlohlona, ho se sebetse hantle, urticariaangioedema.

Ho nka sethethefatsi sena le hona ho ka ama matšoao a laboratori: hyperkalemia, keketseho ea creatinine, urea, pokello ea hematocrit le hemoglobin e eketsehileng.

Litaelo tsa ho sebelisa Lorista N (Mokhoa le litekanyetso)

Setlhare se etselitsoe tsamaiso ea molomo. Mohlomong motsoako le lithethefatsi tse ling tse nang le phello ea antihypertensive. Ho nwa moriana ona ha ho a itshetleha ka takatso ya lijo.

Ho khatello ea kelello ea methapo Tekanyetso e nyane e boletsoeng - Letlapa le le leng. Kamora thupelo ea libeke tse tharo, phello e matla ea hypotensive e fihlella. Ho fihlella phello e matla haholoanyane, ho lekane ho nka lipilisi tse peli hang ka letsatsi, e leng tekanyo e phahameng.

Ho bakuli ka bcc e fokotsehileng o lokela ho nka 25 mg ea losartan ka letsatsi. Haeba ho fokotseha ha BCC ho bile teng ha ho ntse ho etsoa duretics ea bohlokoa, joale pele ho qala kalafo le Lorista N, ho bohlokoa ho hlakola tšebeliso ea diuretics.

Tekanyetso ea pele ha e hloke khalemelo ho bakuli ba ho dialysis mahlomola ho hloleha ha rems (bohareng) le bakuli ba tsofetseng(ho feta lilemo tse 65).

Tekanyetso ea letsatsi le letsatsi ea 50 mg ea losartan e laeloa ho fokotsa kotsi ea lefu la pelo le lefu ho bakuli ba fumanoeng ba na le hypertrophy ea methapo ea methapo kapa khatello ea methapo ea methapo. Haeba ho ne ho sa khonehe ho fokotsa khatello ha o nka 50 mg, joale o hloka ho kopanya losartan le hydrochlorothiazide (12,5 mg). Haeba ho hlokahala, losartan e ka eketsoa ho 100 mg ntle le ho fetola tekanyetso ea hydrochlorothiazide. Tekanyo e phahameng ea letsatsi le letsatsi ea lithethefatsi ha ea lokela ho feta matlapa a mabeli.

Litaelo tsa ho sebelisa Lorista ND: setlhare sena se laetsoe ho sa sebetse phello ea kalafo ho tloha ho nka Lorista N. Lithethefatsi Lorista ND li nooa ka tekanyetso e tšoanang ea letsatsi le letsatsi joalo ka Lorista N.

Bongata losartan e na le matšoao a latelang: fokotseho e kholo ea khatello, bradycardia, tachycardia. Haeba matšoao a overdose a fumanoa, ho khothaletsoa kalafo: matšoao a kalafo, matšoao a qobelloang. Hemodialysis ntlheng ena ha e na thuso.

Haeba ho na le overdose hydrochlorothiazide Matšoao a ka hlaha: hypochloremia, hypokalemia, hyponatremia. Tabeng ena, kalafo ea matšoao e laetsoe.

Tšebelisano ea bohlokoahali ea losartan le digoxin, phenobarbital, hydrochlorothiazide, ketoconazolomvarfarin, erythromycin le cimetidine ha e khetholloe.

Boemo ba metabolite bo sebetsang bo fokotseha ha o nka losartan le rifampicin le fluconazole. Le ha ho le joalo, ts'ebelisano e joalo ha e so ithutoe ka tliliniki.

Hyperkalemia e ka hlaha ka ho kopantsoe le motsoako o bolokang potasiamo o pharallang (phenamteren, Lepironolactone, Amiloride), letsoai la potasiamo kapa tlatsetso ea potasiamo.

Ho sebetsa ha losartan ho ka fokotsoa ka lebaka la ho nka NSAIDs le li-inhibitors tse khethiloeng tsa COX-2.

Kamohelo indomethacin ho ka lebisa ho fokotseha hoa phello ea hypotensive lazortana.

Ethanol, lithethefatsi tsa narcotic le barbiturates ha li kopantsoe le hydrochlorothiazide, li ka baka hypotension ea orthostatic.

Ho amoheloa ka nako e le 'ngoe hypoglycemic agents (ho kenyeletsa insulin) e ka hloka phetoho ea tekanyetso.

Matla a eketsang a ka hlaha ha o kopanya kalafo le ba bang antihypertgency agents.

Ho sitisa ho amoheloa ha hydrochlorothiazide e ka ba lithethefatsi tse kang colestipol kapa colestyramine.

Hydrochlorothiazide e ka ntlafatsa katleho ea mesifa ea ho phomola (tudocurarin).

Litlamorao tsa natriuretic, hypotensive, le diuretic tsa hydrochlorothiazide li ka fokotseha ka lebaka la ts'ebeliso ea NSAIDs(ho kenyelletsa le li-inhibitors tsa COX-2).

Liphumano tsa laboratori tsa ts'ebetso ea parathyroid li ka khopamisoa ka lebaka la phello ea hydrochlorothiazide ho metabolism ea calcium.

Li-Pharmace li rekisoa feela ka lengolo la ngaka.

Setlhare se lokela ho bolokoa sebakeng se lefifi eseng se mongobo. Mocheso o phahameng ke 30 ° C.

Motsoako o ka khonehang le lithethefatsi tse ling tsa antihypertensive.

Tekanyetso ea pele ea bakuli ba tsofetseng ha e fetoloe ka ho khetheha.

Hydrochlorothiazide e kanna ea eketseha hypotension ea methapo le ho senya tekanyo ea electrolyte ea metsi. Hape ho ka ba le mamello ea tsoekere e nyonyehang, ho fokotseha ha calcium ka moroto, e leng se ka lebisang keketseho e nyane ea likhalsiamo tsa mali.

Ho nts'etsapele lithethefatsi II kapa III trimester nakong ea kemolo ho ka baka lefu la fetal. Setlhare se lokela ho khaotsa haeba ho ima ho hlaha. Lesea le sa tsoa hlaha le ka hlaha jaundicemme thrombocytopenia.

Ho nka moriana ona ho bakuli ba bangata ha ho ame bokhoni ba ho etsa mesebetsi e hlokang ho tsepamisa maikutlo. Leha ho le joalo, bakuli ba bang qalong ea kalafo ba ka bona ho fokotseha ho hoholo ha khatello, ho tsekela. Pele o qala mosebetsi o joalo, ho hlokahala hore a hlahlobe boemo kamora ho qeta moriana.

Ho li-analogues Lorista N li kenyelletsa: angizar plus, lehar forte, setsi sa kopane, Lozap Plus, senotlolo, nostasartan n, hanear-g.

Litemana tsohle tse kaholimo li sebetsa le mehlaleng ea Lorista ND.

Palo e tloaelehileng ea lithethefatsi ke lintlha tse 4,5 (ho tse 5). Bareki ba hlokomela ho sebetsa ha sethethefatsi, phello e bonolo ea sona. Har'a mefokolo ke tlhoko ea ho nka letsatsi le leng le le leng le lipontšo tsa litla-morao.

Maikutlo a matle a tsoang ho lingaka ka lithethefatsi a re e sebetsa ka botlalo. Leha ho le joalo, litsebi li hlokometse hore hoa hlokahala ho e sebelisa ka hloko litekanyetso tse behiloeng ke ngaka e le ho fokotsa kotsi ea litla-morao.

Litlhahlobo mabapi le Lorist ND lekola litlhahlobo mabapi Lorena N.

Theko Li-Lorists ND Russia e sebelisa li-ruble tse 350, Ukraine - 112 UAH.

Karolelano ea theko ea Lorena N Russia - li-ruble tse 214, Ukraine - 114 UAH.

ETSA QETSO!
Tlhahisoleseling mabapi le meriana setsing sa marang-rang ke mofuta-kakaretso Pele u sebelisa lithethefatsi Lorista N / ND, etsa bonnete ba hore u buisana le ngaka ea hau.

Etsa liqeto

Ho hlaseloa ke pelo le stroke ke sesosa sa hoo e ka bang 70% ea mafu ohle lefatšeng. Batho ba supileng ho ba leshome ba shoa ka lebaka la ho phatloha ha methapo ea pelo kapa bokong.

Ho hobe ka ho fetesisa ke taba ea hore batho ba bangata ha ba na ho belaela hore ba na le khatello ea mali. 'Me ba hloloheloa monyetla oa ho lokisa ho hong, ba ipolaisa lefu.

Ho opeloa ke hlooho
Lipallo tsa pelo
Matheba a maputsoa ka pel'a mahlo (lintsintsi)
Ho hloka kutloelo-bohloko, ho teneha, ho otsela
Pono e lerootho
Ho rohaka
Mokhathala o sa foleng
Ho ruruha ha sefahleho
Bolo le ho chaba ha menoana
Khatello ea khatello

Le e 'ngoe ea matšoao ana e lokela ho etsa hore u nahane. Haeba ho na le tse peli, u seke oa tsilatsila - o na le khatello ea mali.

U ka phekola khatello ea mali joang ha ho e-na le palo e kholo ea lithethefatsi e jang chelete e ngata?

Boholo ba lithethefatsi bo ke ke ba thusa letho, 'me tse ling li ka ba tsa baka kotsi! Hona joale, setlhare feela se khothalletsoang ka molao ke Lefapha la Bophelo bakeng sa kalafo ea khatello ea mali ke Hyperten.

Ho fihlela ka la 26 Hlakubele. Setsi sa Cardiology, hammoho le Lekala la Bophelo, se tsamaisa lenaneo " ntle le khatello ea mali"Moo Hyperten e fumanehang teng MAHALA , baahi bohle ba toropo le sebaka!

Ha ke tsebe hore, ho 'na, lithethefatsi tse ngata ke litšila tse ngata, ke tšenyo ea chelete.Na u ne u tla tseba hore na ke se ke lekile ntho e 'ngoe le e' ngoe .. Ke Hyperten feela ka tloaelo e thusitsoeng (ka tsela, ho latela lenaneo le ikhethileng, o ka e fumana hoo e batlang e le mahala). Ke e noetse libeke tse 4, kamora beke ea pele ke nkile, bophelo ba ka bo ile ba ntlafala. Ho se ho fetile likhoeli tse 4 ho tloha ka nako eo, khatello e le ntho e tloaelehileng, 'me ha ke hopole ka khatello ea mali e ngata! Ho bolela hore ka linako tse ling ke boetse ke noella matsatsi a 2-3, bakeng sa thibelo. Mme ke ithutile ka eena ka ho sa feleng, ho tsoa sengoloa sena ..

Lorista N / N

Tlhaloso e amanang le 07.05.2014

Lebitso la Latin: Lista H, Lorena HD
Khoutu ea ATX: C09DA01
Lintho tse sebetsang: Losartan, Hydrochlorothiazide (Hydrochlorothiaz>

Letlapeng le leng la lithethefatsi Lorista N e na:

50 mg losartan potasiamo,
12,5 mg hydrochlorothiazide,
magnesium e bohale, MCC, lactose monohydrate, setlolo sa pregelatinized.

Matlapa a lithethefatsi Lorista ND na:

100 mg losartan potasiamo,
25 mg nidrohlortiziada,
magnesium e bohale, MCC, lactose monohydrate, setlolo sa pregelatinized.

Khetla e na le hypromellosedae ea quinoline (mosehla), talc, macrogol 4000 le titanium dioxide (E171).

Contraindication

Lithethefatsi ka bobeli ha lia lokela ho sebelisoa maemong a latelang:

anuria,
qhekello marang-rang,
hyperkalemia,
hypokalemia e hanyetsang,
ho senyeha ha renal kapa ho sebetsa ha sebete,
galactosemia,
ho omella,
hypotension ea methapo,
boimana
glucose kapa galactose malabsorption syndrome,
lebone
kutloisiso ea karolo efe kapa efe, ho sulfonamide derivatives,
ka tlase ho lilemo tse 18.

Sebelisa ka hlokolosi ha u:

lefu la tsoekere,
bilteryal renal artery stenosis,
tlolo ea tekanyo ea mali-electrolyte ea mali (hypomagnesemia, hypochloremic alkalosis, hyponatremia, hypokalemia),
lesapo la mokokotlo la meno,
mafu a systemic mali
hyperuricemia,
nalane ea lintho tsohle
hypercalcemia,
gout,
asthma ea bronchial,
ka nako e tšoanang le NSAIDs.

Litlamorao

Litlamorao tse latelang li ka hlaha ka lebaka la ho sebelisa meriana ena.

ho tsekela (ha e tsamaisoe ebile e hlophisehile), ho hloka boroko, migrainehlooho e bohloko, mokhathala,
palpitations, hypotension e amanang le dithamine, tachycardiamaemong a matla - vasculitis,
khohlela, ho ruruha ha mucosa ea ka mpeng, pharyngitistšoaetso ea phefumoloho (likarolo tse holimo),
ho nyekeloa ke pelo, bohloko ba ka mpeng, lets'olloho hlatsa dyspepsia, maemong a sa tloaelehang, hepatitis, keketseho ea tšebetso ea li-enzyme tsa sebete, bilirubin, ts'ebetso ea ho fokola ha sebete,
bohloko ba morao arthralgia,myalgia,
Shenlein-Genoch pherese, phokolo ea mali,
bofokoli, bohloko ba sefuba, astheniaedema e haufi,
ho hlohlona, ho se sebetse hantle, urticariaangioedema.

Ho nka sethethefatsi sena le hona ho ka ama matšoao a laboratori: hyperkalemia, keketseho ea creatinine, urea, pokello ea hematocrit le hemoglobin e eketsehileng.

Bongata

Haeba ho na le overdose hydrochlorothiazide Matšoao a ka hlaha: hypochloremia, hypokalemia, hyponatremia. Tabeng ena, kalafo ea matšoao e laetsoe.

Tšebelisano